Including Flexible, Removable Lining Therein Patents (Class 494/45)
  • Patent number: 6458067
    Abstract: A removable conformal liner for a centrifuge container is described. The liner has a flexible or semi-rigid body with an opening for introducing a sample. When the liner is inserted into an internal cavity of a centrifuge container, the body of the liner conforms to the interior cavity. The liner body may be made of a material that is sufficiently resilient to allow a reversible deformation of the body by folding, twisting, collapsing, rolling, or pleating. Also disclosed is a centrifuge container assembly, including a container suitable for centrifuging and a removable liner with a flexible or semi-rigid body placed into the container. The centrifuge container assembly of this invention may also have retaining-means for retaining the liner in a fixed position within the container. Also provided by the present invention is a method for separating solids from suspensions by centrifugation.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: October 1, 2002
    Assignee: Beckman Coulter, Inc.
    Inventors: Melvin Dorin, Patrick Q. Moore
  • Publication number: 20020119880
    Abstract: The claimed invention relates to a method and a device for processing blood concentrate products before they are exposed to a continued process for extracting those remaining medicinally interesting sub-components. The appropriate pre-processing, in relation to the invention, primarily entails a mechanically powered resolution of the viscous flowing concentrate products in a diluting solution for the adaptation of the total products for a renewed centrifuging.
    Type: Application
    Filed: November 30, 2001
    Publication date: August 29, 2002
    Applicant: Gambro, Inc.
    Inventors: Niclas Hogberg, Emanuel Hallgren, Peter Pihlstedt
  • Publication number: 20020107131
    Abstract: A multiple sample processing apparatus for a continuous flow centrifuge, including a plurality of axially aligned processing chambers and expressor chambers, each chamber comprising an axial opening, in a fixed arrangement, and a plurality of central hubs disposed in the axial openings, the central hubs constructed and arranged to define passages for fluid communication between the chambers and a fluid supply.
    Type: Application
    Filed: October 3, 2001
    Publication date: August 8, 2002
    Inventors: Glen Jorgensen, Keith Rosiello
  • Patent number: 6428700
    Abstract: A centrifuge filter for removing soot from engine oil. The centrifuge filter includes a rotor adapted to be rotated inside a centrifuge housing by an electric motor or other means. The rotor preferably includes a reusable aluminum support casing and a disposable plastic cartridge. The plastic cartridge includes a trap with partition walls to prevent wave formation in the rotating liquid contained in the trap. The cartridge includes an annular inlet through its top end, a winding flow path through the cartridge and an outlet at the bottom enc. The centrifuge housing includes an isolated sealed rotor chamber. Using the venturi effect, air is evacuated from the rotor chamber to provide a partial vacuum to reduce air drag on the rotor. Resilient rubber vibration isolators are used to reduce vibrations and engine induced shock loads from reaching the rotating element. A side oil inlet is provided in the cartridge to receive unfiltered oil at a location offset from the axis of rotation.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: August 6, 2002
    Assignee: Baldwin Filters, Inc.
    Inventors: Gene W. Brown, Steven J. Merritt
  • Patent number: 6426010
    Abstract: The invention concerns a device for separating the constituents of a heterogeneous mixture and its uses. Said device comprises a separation chamber (100, 250, 350, 450, 650, 724, 850, 903, 1106) having a one of its ends an inlet and at the other an outlet comprising a first ring-shaped orifice (110, 210, 310, 410, 510, 610, 710, 810, 919) coaxial with said chamber, and a second ring-shaped orifice (111, 211, 311, 411, 511, 611, 711, 811, 920) coaxial with said first ring-shaped orifice and whereof the external diameter is smaller than said first ring-shaped orifice internal diameter. The invention is characterized in that said separation chamber has a cylindrical shape and said first orifice external diameter D1 is smaller than said chamber internal diameter D0. The invention also concerns a method using said device.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: July 30, 2002
    Assignee: Total
    Inventors: Yves Lecoffre, Jean-Claude Gay
  • Publication number: 20020094927
    Abstract: A yoke rotates an umbilicus about a rotational axis, which, in turn, imparts rotation to a blood processing chamber coupled to the umbilicus. The yoke carries first and second umbilicus support surfaces that inhibit travel of the umbilicus in radial directions toward and away from the rotational axis.
    Type: Application
    Filed: October 13, 2001
    Publication date: July 18, 2002
    Applicant: Baxter International Inc.
    Inventors: Sanjay Odak, Michael Kast, Vaughn E. Rice, Tom Westberg, Kelly B. Smith, Michel Joie, Mark R. Vandlik
  • Publication number: 20020091057
    Abstract: A blood separation chamber comprises a base that includes formed walls that define a hub. A separation channel extends about the hub. A flow passage extends between the hub and the separation channel. The hub enables attachment of external tubing to convey blood to and from the separation channel through the hub.
    Type: Application
    Filed: October 15, 2001
    Publication date: July 11, 2002
    Applicant: Baxter International Inc.
    Inventors: Tom Westberg, Kelly Smith, Sanjay V. Odak, Michel L. F Joie, Georges Rondeau
  • Publication number: 20020086788
    Abstract: The claimed invention refers to a centrifuge intended for processing blood and blood components and with its function based on theeffective utilization of ring type blood processing bags with associated secondary bags and other accessories. The most outstanding feature of the centrifuge, in accordance with the claimed invention, is that its rotor, at the same intended height of the ring bag (22) inner periphery, shows at least three supports (9-11) arranged along this periphery and intended to locate the ring bag's inner strengthened periphery edge on guide holes at the same time as the centrifuge and its rotor is equipped with a joint rotating inner lid (6) which includes a clamp function (7) that clamps ring bag (22) securely along and between supports (9-11).
    Type: Application
    Filed: November 30, 2001
    Publication date: July 4, 2002
    Applicant: Gambro, Inc.
    Inventors: Niclas Hogberg, Emanuel Hallgren, Peter Pihlstedt
  • Publication number: 20020068674
    Abstract: A centrifugal fluid separation system is disclosed for centrifugally separating a composite fluid into components thereof. This centrifugal separation system includes at least a centrifugal rotor which has a composite fluid containment area, several fluid flow channels and at least two separated component collection areas defined therein. A composite fluid to be separated is delivered to the fluid containment area from which it travels through an inlet channel to a substantially circumferential fluid separation channel where under centrifugal forces the composite fluid is separated into components which each then travel to distinct first and second separated fluid outlet channels, and thence on to exit therefrom into the respective collection areas. The first and second fluid outlet channels also have respective first and second heights which are related to each other so as to provide a balanced fluid pressure relationship for the respective separated component fluids flowing therethrough.
    Type: Application
    Filed: November 2, 2001
    Publication date: June 6, 2002
    Applicant: Gambro, Inc.
    Inventors: Dennis J. Hlavinka, Thomas J. Felt
  • Publication number: 20020068675
    Abstract: A centrifugal separation device for use in a fluid separation system to centrifugally separate a composite fluid into the composite components thereof. This centrifugal separation device includes a centrifugal rotor housing and a rotor which is disposed in a freely rotatable disposition within the housing, the rotor having a fluid receiving area and several fluid flow channels defined therein. A composite fluid to be separated is delivered to the fluid receiving area from which it travels through a radial fluid transport channel to a circumferential fluid separation channel where it is subjected to substantial centrifugal forces which separate the composite fluid into components which each then travel to distinct first and second separated fluid outlet channels. The separated fluids then exit from these outlet channels and are then moved from the separation device to a collection bag for storage or may then be returned to the donor.
    Type: Application
    Filed: November 2, 2001
    Publication date: June 6, 2002
    Applicant: Gambro, Inc.
    Inventors: Thomas J. Felt, Dennis J. Hlavinka
  • Publication number: 20020061808
    Abstract: A centrifuge with an associated container system in the form of cassettes for separation and/or treatment of blood or blood components. The centrifuge comprises a rotor (1) having a central compartment in the form of a tubular shaft cavity (6) extending concentrically with the axis of rotation of the rotor and an annular separation compartment (5) which is arranged around said cavity at a the upper part thereof.
    Type: Application
    Filed: January 22, 2002
    Publication date: May 23, 2002
    Applicant: Gambro, Inc.
    Inventors: Peter Unger, Eric Westberg
  • Publication number: 20020058575
    Abstract: An apparatus and method are provided for separating components of a fluid or particles. A separation vessel having a barrier dam is provided to initially separate an intermediate density components of a fluid, and a fluid chamber is provided to further separate these intermediate density components by forming an elutriative field or saturated fluidized particle bed. The separation vessel includes a shield for limiting flow into the fluid chamber of relatively high density substances, such as red blood cells. The separation vessel also includes a trap dam with a smooth, gradually sloped downstream section for reducing mixing of substances. Structure is also provided for adding additional plasma to platelets and plasma flowing from the fluid chamber. The system reduces clumping of platelets by limiting contact between the platelets and walls of the separation vessel.
    Type: Application
    Filed: November 1, 2001
    Publication date: May 16, 2002
    Applicant: Gambro, Inc.
    Inventors: Dennis Hlavinka, Thomas J. Felt
  • Patent number: 6387030
    Abstract: A removable adapter for a centrifuge container is described. The adapter has an opening on top, an exterior surface and an interior surface. The exterior surface of the adapter body completely conforms to the bottom portion of the centrifuge container cavity. The interior surface of the adapter body has an internal sidewall and a bottom with a pellet well. The pellet well extends downwardly, toward the exterior surface. Also, an assembly is disclosed, including the adapter of the present invention with a pellet well and a liner, conforming to the interior surface of the adapter, once inside the adapter. Also provided by the present invention is a method for separating solids from suspensions by centrifugation. In this method, the removable adapter with a pellet well of the present invention is placed into a centrifuge container. Then, the suspension is placed into the centrifuge container. When centrifugation is completed, the pellet is removed from the pellet well.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: May 14, 2002
    Assignee: Beckman Coulter, Inc.
    Inventors: Patrick Q. Moore, Shahla Sheikholeslam
  • Patent number: 6354986
    Abstract: A method is provided for separating components of a fluid or particles. In one disclosed method, a substance, such as whole blood, is initially separated in a separation vessel provided on a rotating centrifuge rotor. Liquid (i.e., plasma) and at least first and second particles (i.e., white blood cells and platelets) are conveyed from the separation vessel to fluid chamber also provided on the rotating centrifuge rotor. At least some of the first particles are retained in the fluid chamber and at least some of the second particles flow from an outlet of the fluid chamber along with the liquid. After a period of time, the direction of flow in the fluid chamber is reversed to pass the retained first particles back into the separation vessel where the first particles are removed. This reversal of flow direction ensures that the number of first particles in the fluid chamber does not exceed the fluid chamber's capacity to retain these particles.
    Type: Grant
    Filed: February 16, 2000
    Date of Patent: March 12, 2002
    Assignee: Gambro, Inc.
    Inventors: Dennis Hlavinka, Thomas J. Felt
  • Publication number: 20020020679
    Abstract: A sealed centrifugal clarifier with a pre-sterilized and disposable container which lines the separation chamber is disclosed. More particularly, the centrifugal clarifier contains a feed port that allows a liquid-solid mixture to be continuously fed into the device wherein the solid is sedimented by rotation of the separation chamber and the clarified liquid is released into an outside receptacle through an effluent port. The throughput rate of the clarifier is adjustable and can be determined as a function of the fill radius of the separation chamber.
    Type: Application
    Filed: April 11, 2001
    Publication date: February 21, 2002
    Inventors: Glen Jorgensen, William F. Aitkenhead, Joseph D. Antocci
  • Patent number: 6348031
    Abstract: A centrifuge with an associated container system in the form of cassettes for separation and/or treatment of blood or blood components. The centrifuge comprises a rotor having a central compartment in the form of a tubular shaft cavity extending concentrically with the axis of rotation of the rotor and an annular separation compartment which is arranged around said cavity at the upper part thereof. A first container system arranged in the rotor for washing of blood cells comprises a round bag with two or more flexible secondary containers connected thereto, of which at least one contains a treatment liquid, and a tubular sleeve adapted to the shaft cavity of the rotor. The secondary containers stand in the sleeve resting against each other, and the round bag is mounted on a projecting flange at the upper part of the sleeve.
    Type: Grant
    Filed: August 12, 1999
    Date of Patent: February 19, 2002
    Assignee: Gambro, Inc.
    Inventors: Peter Unger, Eric Westberg
  • Patent number: 6348156
    Abstract: Blood processing systems and methods employ two sensors, one to detect a condition of plasma exiting a separation device and another sensor to detect a condition of a cellular component exiting the separation device. The first sensor detects, e.g., contamination of the plasma due to presence of unwanted cellular components. The second sensor detects, e.g., dilution of the cellular component due to presence of plasma. Blood processing parameters are carried out based, at least in part, by conditions detected by one or both of the sensors.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: February 19, 2002
    Assignee: Baxter International Inc.
    Inventors: Rohit Vishnoi, Tom Westberg, Matthew R. Muller, Kelly B Smith, Michel L. F. Joie, Mark R Vandlik
  • Publication number: 20020016244
    Abstract: Method of separating cells in a centrifuge, preferably for producing platelets. A cell suspension is provided in a processing bag and is centrifuged. The cell enriched fraction is transferred to a storage bag via an outlet tube. The outlet tube is arranged with a portion thereof in a position adjacent the periphery of the centrifuge. When the enriched fraction is transferred through the outlet tube placed at the periphery of the centrifuge and during centrifugation, the outlet tube operates as a cell trap and the enriched fraction is further separated. Preferably, the cell suspension is buffy coat and the enriched fraction comprises platelets. The corresponding bag assembly comprises a processing bag intended to enclose the cell suspension. The processing bag is placed in a centrifuge rotor for separating the cells into a fraction enriched on platelets by centrifugation.
    Type: Application
    Filed: October 15, 2001
    Publication date: February 7, 2002
    Inventors: Peter Unger, Eric Westberg
  • Patent number: 6334842
    Abstract: An apparatus and method are provided for separating components of a fluid or particles. A separation vessel having a barrier dam is provided to initially separate an intermediate density components of a fluid, and a fluid chamber is provided to further separate these intermediate density components by forming an elutriative field or saturated fluidized particle bed. The separation vessel includes a shield for limiting flow into the fluid chamber of relatively high density substances, such as red blood cells. The separation vessel also includes a trap dam with a smooth, gradually sloped downstream section for reducing mixing of substances. Structure is also provided for adding additional plasma to platelets and plasma flowing from the fluid chamber. The system reduces clumping of platelets by limiting contact between the platelets and walls of the separation vessel.
    Type: Grant
    Filed: March 16, 1999
    Date of Patent: January 1, 2002
    Assignee: Gambro, Inc.
    Inventors: Dennis Hlavinka, Thomas J. Felt
  • Patent number: 6315706
    Abstract: Method of separating cells in a centrifuge, preferably for producing platelets. A cell suspension is provided in a processing bag and is centrifuged. The cell enriched fraction is transferred to a storage bag via an outlet tube. The outlet tube is arranged with a portion thereof in a position adjacent the periphery of the centrifuge. When the enriched fraction is transferred through the outlet tube placed at the periphery of the centrifuge and during centrifugation, the outlet tube operates as a cell trap and the enriched fraction is further separated. Preferably, the cell suspension is buffy coat and the enriched fraction comprises platelets. The corresponding bag assembly comprises a processing bag intended to enclose the cell suspension. The processing bag is placed in a centrifuge rotor for separating the cells into a fraction enriched on platelets by centrifugation.
    Type: Grant
    Filed: August 13, 1998
    Date of Patent: November 13, 2001
    Assignee: Gambro, Inc.
    Inventors: Peter Unger, Eric Westberg
  • Patent number: 6296602
    Abstract: A method for collecting, from whole blood, platelets suspended in plasma. By centrifuging the blood at a high enough rotational speed, the platelets are separated from the plasma and the red blood cells. In a preferred embodiment, some of the plasma is removed while the centrifuge is being spun to keep the platelets separated from the plasma. Then, the speed of rotation is altered so as to cause the platelets to mix with the remaining plasma. The platelets can then be collected with the remaining plasma.
    Type: Grant
    Filed: March 17, 1999
    Date of Patent: October 2, 2001
    Assignee: Transfusion Technologies Corporation
    Inventor: Thomas D. Headley
  • Patent number: 6280375
    Abstract: A centrifuge, especially a flow-through centrifuge free of rotating seals, for centrifuging biological fluids has a stand on which a frame (1) is rotatably mounted. A centrifuge chamber (3) is rotatably mounted on the rotating frame (1) to rotate about the axis of the latter. The centrifuge chamber (3) is driven in the same direction of rotation as the frame (1) but at twice the rotational speed. Coupling elements which are engaged by magnetic forces and are designed in the manner of a clutch disk or a gearwheel are used to transmit the torque to the centrifuge chamber or the rotating frame. Force is transmitted in a non-contact and wear-free manner. No lubrication is necessary, which also reduces the buildup of dust and dirt. In addition, there is little generation of noise.
    Type: Grant
    Filed: January 19, 1999
    Date of Patent: August 28, 2001
    Assignee: Fresenius AG
    Inventors: Artur Meisberger, Wolfram Weber, Carlo Lay, Friederich Witthaus, Stefan Kreber, Henning Brass
  • Patent number: 6277060
    Abstract: A centrifuge chamber of a cell separator having a separation channel with an inlet to introduce the cell suspension and at least one outlet to withdraw a fraction of the cell suspension is described. The cell suspension can be blood. The separation channel is shaped like a spiral extending from the radially outer end of the channel to the radially inner end of the channel, with a progressive slope. The centrifuge chamber allows a uniform, contaminant free separation of the cell suspension into its components.
    Type: Grant
    Filed: September 10, 1999
    Date of Patent: August 21, 2001
    Assignee: Fresenius AG
    Inventor: Hans-J├╝rgen Neumann
  • Patent number: 6261217
    Abstract: A separation set for blood component preparation and similar separations for use in a centrifuge rotor, the set including a plate-like separation container made of a flexible material, an annular pinch valve which is mounted on and divides the separation container into a central section and an annular outer section, a first component container which is connected to the center of the separation container, a second component container which is connected to the circumference of the separation container, and a blood withdrawal tube for supplying blood to the outer section. The blood is separated in the outer section into plasma, buffy coat and red blood cells. Then the plasma is displaced to the first component container and the buffy coat to the central section where it is enclosed through the action of the pinch valve. The separation set with the pinch valve is then removed from the centrifuge and the red blood cells are transferred to the second component container.
    Type: Grant
    Filed: October 18, 1999
    Date of Patent: July 17, 2001
    Assignee: Sanguistech Aktiebolag
    Inventors: Peter Unger, Eric Westberg
  • Patent number: 6251284
    Abstract: Blood separation systems and methods draw whole blood from a blood donor selected from a population of blood donors. The whole blood of the selected blood donor has a known hematocrit value that varies within the population of blood donors according to morphology of the selected blood donor. The systems and methods operate a pump in the inlet line to convey a volume of whole blood from the donor at a commanded flow rate for processing into plasma constituent and concentrated red blood cells. The systems and methods set the commanded flow rate to vary the volume of whole blood conveyed over time as a function of the known hematocrit value of the selected donor. The systems and methods obtain, after processing the whole blood volume, a targeted volume of concentrated red blood cells, which is substantially constant for the population of blood donors despite variances in known hematocrit values among the donors.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: June 26, 2001
    Assignee: Baxter International Inc.
    Inventors: Daniel F Bischof, Matthew E Likens, Richard P Goldhaber, Jose C Deniega, Daniel H Duff
  • Patent number: 6231537
    Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.
    Type: Grant
    Filed: January 21, 1998
    Date of Patent: May 15, 2001
    Assignee: Gambro, Inc.
    Inventors: Brian M. Holmes, Jeffrey J. Blakeslee, Marlene Adele Bainbridge, Frank Corbin, III
  • Patent number: 6228017
    Abstract: A chamber for use in a rotating field to separate blood components. An inlet port near one end of the chamber introduces blood into the chamber for flow circumferentially about the rotational axis toward the opposite end of the chamber for separation into at least one blood component. At least one outlet port is juxtaposed next to the inlet port near the one end of the chamber for conveying one separated blood component from the channel. The chamber directs the one separated blood component to a collection region near the opposite end of the chamber. An enclosed interior collection passage within the channel leads from the collection region and directs the one collected component to the outlet port for transport from the chamber.
    Type: Grant
    Filed: May 14, 1997
    Date of Patent: May 8, 2001
    Assignee: Baxter International Inc.
    Inventor: Richard I. Brown
  • Patent number: 6168561
    Abstract: Blood processing systems and methods rotate a processing chamber on a rotating element. The processing chamber includes a first compartment and a second compartment. Blood is conveyed into the first compartment for centrifugal separation into components. A liquid free of blood occupies the second compartment to counter-balance the first compartment during rotation on the rotating element. In one embodiment, the second compartment is served by a single fluid flow access. Prior to use, the single access is coupled to tubing, through which a vacuum is drawn to remove air from the second compartment. While the vacuum exists, communication is opened between the tubing and a source of liquid. The vacuum draws the liquid into the second compartment through the single access, thereby priming the second compartment for use.
    Type: Grant
    Filed: August 19, 1999
    Date of Patent: January 2, 2001
    Assignee: Baxter International Inc.
    Inventors: Robert J Cantu, Kyungyoon Min, Douglas W Reitz
  • Patent number: 6129656
    Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: October 10, 2000
    Assignee: Cobe Laboratories, Inc.
    Inventors: Jeffrey J. Blakeslee, Brian M. Holmes, Victor D. Dolecek
  • Patent number: 6123696
    Abstract: A method and apparatus for the sequestration of components of a fluid by forcing heavier fractions of the fluid to pass beyond a yieldable partition integrally formed within a bag. Fluid fractions remain sequestered within bag compartments when forces driving the heavier fraction have been removed.
    Type: Grant
    Filed: July 16, 1998
    Date of Patent: September 26, 2000
    Assignee: ThermoGenesis Corp.
    Inventors: Philip Henry Coelho, Pablo Rubinstein
  • Patent number: 6074335
    Abstract: A rotor for collecting and centrifuging biological fluids in a range of volumes. The rotor includes an elastic impermeable diaphragm which defines at least a portion of a variable-volume processing chamber, where the fluid is centrifuged. The rotor includes a rigid mounting member, to which the diaphragm is mounted and which is held and spun by a chuck. Preferably, this rigid mounting member includes a boundary wall which together with the elastic diaphragm defines the chamber. The boundary wall may be a substantially imperforate circular wall which extends to the periphery of the processing chamber but defining one opening, preferably near the axis of rotation, permitting a conduit or conduits to pass therethrough so as to be in fluid communication with the processing chamber. The rotor may include a separate structure for controlling the flow of liquid out of the chamber into the conduit.
    Type: Grant
    Filed: February 12, 1997
    Date of Patent: June 13, 2000
    Assignee: Transfusion Technologies Corporation
    Inventors: Thomas D. Headley, Edward T. Powers
  • Patent number: 6071422
    Abstract: An apparatus and method are disclosed for filtering or separating particles. The apparatus has a centrifuge rotor rotatable about an axis of rotation. A fluid chamber rotates with the rotor. A substance is supplied to the inlet of the chamber. A saturated fluidized bed of first particles forms within the fluid chamber and obstructs flow of second particles through the chamber. Additive substances alter sedimentation velocity of the first particles to modify the filtration characteristics of the saturated fluidized bed.
    Type: Grant
    Filed: May 26, 1998
    Date of Patent: June 6, 2000
    Assignee: Cobe Laboratories, Inc.
    Inventors: Dennis Hlavinka, Frank Corbin
  • Patent number: 6053856
    Abstract: An apparatus and method are provided for separating components of a fluid or particles. A separation vessel having a barrier dam is provided to initially separate an intermediate density components of a fluid, and a fluid chamber is provided to further separate these the intermediate density component by forming an elutriative field or saturated fluidized particle bed. The separation vessel is placed in a retainer on a centrifuge rotor and ridges in the retainer form various dams in the separation vessel. Also discloses are tubing sets and various separation vessels for use with the apparatus.
    Type: Grant
    Filed: May 8, 1997
    Date of Patent: April 25, 2000
    Assignee: Cobe Laboratories
    Inventor: Dennis Hlavinka
  • Patent number: 6022306
    Abstract: The instant invention relates to a method and the apparatus for collecting a hyperconcentrated platelet product. A fluid containing platelets and other particles flows into a fluid chamber at a flow rate. The flow rate of the fluid is selected to retain the majority of the platelets in the fluid chamber in a saturated bed. The platelets are collected from the fluid chamber without collecting the other particles to form a hyperconcentrated other particle reduced platelet product.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: February 8, 2000
    Assignee: COBE Laboratories, Inc.
    Inventors: Larry Joe Dumont, Linda A. Taylor, Geert Van Waeg
  • Patent number: 5993370
    Abstract: A separation zone for separating platelets from a platelet-rich suspension establishes a relationship between its radial thickness (h) and axial height (Z) that, taking into account the given angular velocity of rotation and the given kinematic viscosity of the platelet-rich suspension introduced through the inlet, represents a (.lambda.) value that is less than 700,where ##EQU1## where: .OMEGA. is the angular velocity (in rad/sec);h is the radial depth (or thickness) of the chamber (in cm);.upsilon. is the kinematic viscosity of the fluid being separated (in cm.sup.2 /sec); andZ is the axial height of the chamber (in cm).
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: November 30, 1999
    Assignee: Baxter International Inc.
    Inventors: Richard I. Brown, Dale R. Ellis
  • Patent number: 5916082
    Abstract: This separator is a centrifugal device for separating solids from contaminated effluent such as oil or water base coolants and other liquids which are used in a variety of grinding and machining applications in the glass, ceramic and metal-forming industries. A containment liner or bladder lines the interior of the separator and communicates with fluid inlets and outlets. An inlet orifice allows for the pulling of a vacuum which holds the bladder in place on the interior walls of the separator. Periodically, rotation is stopped, vacuum is released and the bladder is allowed to invert and drop below the separator. Hanging in this inverted position, it is easy to clean or remove the solids from the inverted bladder.
    Type: Grant
    Filed: August 12, 1998
    Date of Patent: June 29, 1999
    Assignee: Glassline Corporation
    Inventor: Mark H. Opfer
  • Patent number: 5913768
    Abstract: An apparatus and method are disclosed for filtering or separating particles. The apparatus has a motor coupled to a centrifuge rotor rotatable about an axis of rotation. A fluid chamber rotates with the rotor. A substance is supplied to the inlet of the chamber. At least one of the motor and the substance supply are controlled to maintain a saturated fluidized bed of first particles within the fluid chamber while causing second particles to be retained in the chamber.
    Type: Grant
    Filed: July 5, 1996
    Date of Patent: June 22, 1999
    Assignee: Cobe Laboratories, Inc.
    Inventors: Robert Langley, Dennis Hlavinka, Linda A. Taylor, John C. Walker
  • Patent number: 5906570
    Abstract: An apparatus and method are disclosed for filtering or separating particles. The apparatus has a motor coupled to a centrifuge rotor rotatable about an axis of rotation. A fluid chamber rotates with the rotor. A substance is supplied to the inlet of the chamber. At least one of the motor and the substance supply are controlled to maintain a saturated fluidized bed of first particles within the fluid chamber while causing second particles to be retained in the chamber.
    Type: Grant
    Filed: August 4, 1997
    Date of Patent: May 25, 1999
    Assignee: Cobe Laboratories, Inc.
    Inventors: Robert Langley, Dennis Hlavinka, Linda A. Taylor, John C. Walker
  • Patent number: 5904645
    Abstract: A centrifuge separation device is disclosed and includes a rotor configured to be connected to a centrifuge motor for rotation about an axis of rotation. A retainer is associated with the rotor and defines a passageway for a separation channel. A protrusion formed in one of the passageway walls extends towards and is spaced from the other of the passageway walls. The protrusion is sized to substantially block passage of materials in a predetermined density range and to substantially permit passage of materials outside of the predetermined density range. An indentation formed adjacent the protrusion in a wall of the passageway opposite the protrusion is configured to trap fluid during rotation of the rotor and to cooperate with the trapped fluid to maintain a substantially Coriolis-free pathway in a region of the passageway adjacent the protrusion.
    Type: Grant
    Filed: May 14, 1997
    Date of Patent: May 18, 1999
    Assignee: COBE Laboratories
    Inventor: Dennis Hlavinka
  • Patent number: 5879280
    Abstract: A centrifuge apparatus is used for collecting white blood cells, primarily mononuclear cells, from whole blood stratified into layers. A thin mononuclear (MNC) layer is formed at the interface of red blood cells and plasma. A barrier is positioned in the separation vessel of the centrifuge at a location to intercept the thin layer. An MNC collect port is positioned in front of the barrier to collect the thin layer. MNC fluid is allowed to pool behind the barrier to surround the collect port before collection is started. Collection ceases when the pool is removed and allowed to build again. By operating the collect in an intermittent fashion, improvements in purity and collect volume are achieved. The intermittent collection procedure can be useful for harvesting granulocytes and, in general, any sparse stratified component of a centrifuged solution where the sparse component is layered between more dense and less dense strata.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: March 9, 1999
    Assignee: COBE Laboratories, Inc.
    Inventors: Dennis Hlavinka, Thomas J. Felt
  • Patent number: 5876321
    Abstract: A centrifuge apparatus is used for collecting white blood cells (WBC), primarily mononuclear cells, from whole blood stratified into layers. A thin mononuclear (MNC) layer is formed at the interface of red blood cells and plasma. A barrier is positioned in the separation vessel of the centrifuge at a location to intercept the thin layer. MNC fluid is allowed to pool behind the barrier before collection is started. To collect the MNC pool, the stratified red blood cell layer is raised from below the interface level by slowing or reversing flow in the RBC exit line thereby causing the MNC pool to spill over the barrier into a well in which a collect line is positioned. Collection ceases when a desired percentage of the pool is removed and the normal position of the interface is re-established; thereafter the pool builds again. By raising the MNC pool from below, improvements in purity and collect volume are achieved.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: March 2, 1999
    Assignee: Cobe Laboratories, Inc.
    Inventors: Dennis Hlavinka, Thomas J. Felt
  • Patent number: 5792038
    Abstract: A centrifuge separation device is disclosed and includes a rotor configured to be connected to a centrifuge motor for rotation about an axis of rotation. A retainer is associated with the rotor and defines a passageway for a separation channel. A protrusion formed in one of the passageway walls extends towards and is spaced from the other of the passageway walls. The protrusion is sized to substantially block passage of materials in a predetermined density range and to substantially permit passage of materials outside of the predetermined density range. An indentation formed adjacent the protrusion in a wall of the passageway opposite the protrusion is configured to trap fluid during rotation of the rotor and to cooperate with the trapped fluid to maintain a substantially Coriolis-free pathway in a region of the passageway adjacent the protrusion.
    Type: Grant
    Filed: May 15, 1996
    Date of Patent: August 11, 1998
    Assignee: Cobe Laboratories, Inc.
    Inventor: Dennis Hlavinka
  • Patent number: 5788662
    Abstract: An inexpensive device with a disposable cartridge for preparing tissue sealant is disclosed. The device is particularly applicable to stat preparation of autologous tissue sealant. A method of sealing tissue in which the tissue sealant is applied immediately after mixing platelet-rich plasma concentrate (from the device) with a solution of calcium and thrombin is also disclosed. Preparation in the operating room of 5 cc sealant from 50 cc patient blood requires less than 15 minutes and only one simple operator step. There is no risk of tracking error because processing can be done in the operating room. Chemicals added may be limited to anticoagulant (e.g., citrate) and calcium chloride. The disposable cartridge may fit in the palm of the hand and is hermetically sealed to eliminate possible exposure to patient blood and ensure sterility. Adhesive and tensile strengths are comparable or superior to pooled blood fibrin sealants made with precipitation methods.
    Type: Grant
    Filed: October 22, 1996
    Date of Patent: August 4, 1998
    Assignee: Plasmaseal LLC
    Inventors: Richard D. Antanavich, Randel Dorian
  • Patent number: 5759147
    Abstract: A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer circumferential wall plus an inner circumferential wall, spaced from the outer wall, to define a circumferential slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 2, 1998
    Assignee: Baxter International Inc.
    Inventors: David V. Bacehowski, Herbert M. Cullis, Armand R. VanBaelen
  • Patent number: 5723050
    Abstract: Apparatus for centrifugal separation of liquid mixtures is disclosed including an inner circular bag and an outer annular bag which has an inner diameter corresponding to the outer diameter of the inner circular bag, a connecting channel for providing fluid communication between the inner and outer bags, and a rigid circular mount for mounting the outer annular bag for centrifugation in a manner such that the outer annular bag adopts a conical configuration by shortening its inner diameter. Methods for centrifugal separation of thrombocyte suspensions and bone marrow cells using this apparatus are also disclosed.
    Type: Grant
    Filed: January 3, 1996
    Date of Patent: March 3, 1998
    Assignee: Omega Medicinteknik AB
    Inventors: Peter Unger, Eric Westberg
  • Patent number: 5720716
    Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 24, 1998
    Assignee: Cobe Laboratories, Inc.
    Inventors: Jeffrey J. Blakeslee, Brian M. Holmes, Victor D. Dolecek
  • Patent number: 5713826
    Abstract: A centrifuge of the type having a rotary basket with a bottom wall, side wall and a top wall with a central opening therein includes a liquid feed pipe extending into the basket through the top opening to a point spaced above the basket bottom wall at the rotary axis thereof for conducting a feed liquid into the basket. A feed accelerator projects from the basket bottom wall opposite the feed pipe. The accelerator rotates with the basket so that, the accelerator will impart radial and angular acceleration to the liquid issuing from the feed pipe so that that liquid is redirected and accelerated toward the basket side wall. The centrifuge also incorporates a liquid drain in the basket bottom wall adjacent to the rotary axis of the basket for draining liquid from the basket when the rotation of the basket is stopped.
    Type: Grant
    Filed: May 7, 1996
    Date of Patent: February 3, 1998
    Assignee: Waterlink, Inc.
    Inventor: James D. West
  • Patent number: 5704889
    Abstract: A centrifuge apparatus is used for collecting white blood cells (WBC), primarily mononuclear cells, from whole blood stratified into layers. A thin mononuclear (MNC) layer is formed at the interface of red blood cells and plasma. A barrier is positioned in the separation vessel of the centrifuge at a location to intercept the thin layer. MNC fluid is allowed to pool behind the barrier before collection is started. To collect the MNC pool, the stratified red blood cell layer is raised from below the interface level by slowing or reversing flow in the RBC exit line thereby causing the MNC pool to spill over the barrier into a well in which a collect line is positioned. Collection ceases when a desired percentage of the pool is removed and the normal position of the interface is re-established; thereafter the pool builds again. By raising the MNC pool from below, improvements in purity and collect volume are achieved.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: January 6, 1998
    Assignee: Cobe Laboratories, Inc.
    Inventors: Dennis Hlavinka, Thomas J. Felt
  • Patent number: 5704888
    Abstract: A centrifuge apparatus is used for collecting white blood cells, primarily mononuclear cells, from whole blood stratified into layers. A thin mononuclear (MNC) layer is formed at the interface of red blood cells and plasma. A barrier is positioned in the separation vessel of the centrifuge at a location to intercept the thin layer. An MNC collect port is positioned in front of the barrier to collect the thin layer. MNC fluid is allowed to pool behind the barrier to surround the collect port before collection is started. Collection ceases when the pool is removed and allowed to build again. By operating the collect in an intermittent fashion, improvements in purity and collect volume are achieved. The intermittent collection procedure can be useful for harvesting granulocytes and, in general, any sparse stratified component of a centrifuged solution where the sparse component is layered between more dense and less dense strata.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: January 6, 1998
    Assignee: Cobe Laboratories, Inc.
    Inventors: Dennis Hlavinka, Thomas J. Felt
  • Patent number: 5702357
    Abstract: An extracorpeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 30, 1997
    Assignee: Cobe Laboratories, Inc.
    Inventors: Marlene Adele Bainbridge, Brian M. Holmes