Including Flexible, Removable Lining Therein Patents (Class 494/45)
  • Patent number: 5690602
    Abstract: A centrifuge comprising a yoke element that rotates about a rotational axis and a processing chamber having an axis. The processing chamber includes a bowl element, a spool element, and a mechanism for joining the spool and bowl elements for relative movement between a mutually cooperating position for centrifugal processing and a mutually separated position for loading. A hinge attaches the processing chamber to the yoke element for pivotal movement between an operating position and an access position. In the operating position, the spool and bowl elements are in their mutually cooperating position and oriented for rotation with the yoke element about the rotational axis. In the access position, the processing chamber axis lies outside the axis of rotation and the spool and bowl elements are oriented for movement from their mutually cooperating position into their mutually separated position.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: November 25, 1997
    Assignee: Baxter International Inc.
    Inventors: Richard I. Brown, Warren P. Williamson, Paul M. Di Perna
  • Patent number: 5656163
    Abstract: A chamber for use in a rotating field to separate blood components. An inlet port near one end of the chamber introduces blood into the chamber for flow circumferentially about the rotational axis toward the opposite end of the chamber for separation into at least one blood component. At least one outlet port is juxtaposed next to the inlet port near the one end of the chamber for conveying one separated blood component from the channel. The chamber directs the one separated blood component to a collection region near the opposite end of the chamber. An enclosed interior collection passage within the channel leads from the collection region and directs the one collected component to the outlet port for transport from the chamber.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: August 12, 1997
    Assignee: Baxter International Inc.
    Inventor: Richard I. Brown
  • Patent number: 5626749
    Abstract: Method of treatment by centrifuging of a liquid packaged in flexible-walled bags connected to at least one filter. According to the method, the filter (2) is placed in the middle of the confinement space (5, 5a) such that the large faces of the filter (2) are parallel to the centrifuging axis (3), and bags (1) are placed on either side of said filter (2) so that they are in contact with the latter.
    Type: Grant
    Filed: November 21, 1994
    Date of Patent: May 6, 1997
    Assignee: Jouan (societe anonyme)
    Inventors: Roland J. L. R. Lambert, Jean-Claude C. M. Letourneur
  • Patent number: 5585007
    Abstract: An inexpensive device with a disposable cartridge for preparing tissue sealant is disclosed. The device is particularly applicable to star preparation of autologous tissue sealant. A method of sealing tissue in which the tissue sealant is applied immediately after mixing platelet-rich plasma concentrate (from the device) with a solution of calcium and thrombin is also disclosed. Preparation in the operating room of 5 cc sealant from 50 cc patient blood requires less than 15 minutes and only one simple operator step. There is no risk of tracking error because processing can be done in the operating room. Chemicals added may be limited to anticoagulant (e.g., citrate) and calcium chloride. The disposable cartridge may fit in the palm of the hand and is hermetically sealed to eliminate possible exposure to patient blood and ensure sterility. Adhesive and tensile strengths are comparable or superior to pooled blood fibrin sealants made with precipitation methods.
    Type: Grant
    Filed: December 7, 1994
    Date of Patent: December 17, 1996
    Assignee: PlasmaSeal Corporation
    Inventors: Richard D. Antanavich, Randel Dorian
  • Patent number: 5571068
    Abstract: A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer arcuate wall plus an inner circumferential wall, spaced from the outer wall, to define a arcuate slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: November 5, 1996
    Assignee: Baxter International Inc.
    Inventors: David V. Bacehowski, Herbert M. Cullis, Armand R. VanBaelen
  • Patent number: 5551942
    Abstract: A centrifuge comprising a yoke element that rotates about a rotational axis and a processing chamber having an axis. The processing chamber includes a bowl element, a spool element, and a mechanism for joining the spool and bowl elements for relative movement between a mutually cooperating position for centrifugal processing and a mutually separated position for loading. A hinge attaches the processing chamber to the yoke element for pivotal movement between an operating position and an access position. In the operating position, the spool and bowl elements are in their mutually cooperating position and oriented for rotation with the yoke element about the rotational axis. In the access position, the processing chamber axis lies outside the axis of rotation and the spool and bowl elements are oriented for movement from their mutually cooperating position into their mutually separated position.
    Type: Grant
    Filed: December 22, 1993
    Date of Patent: September 3, 1996
    Assignee: Baxter International Inc.
    Inventors: Richard I. Brown, Warren P. Williamson, Paul M. Di Perna
  • Patent number: 5547453
    Abstract: A centrifugation system includes frame has at least one weight bearing member for engaging a support surface generally lying in a horizontal plane. The system also includes a centrifuge assembly including a chamber that can be rotated about an axis. A base supports the centrifuge assembly on the frame within the interior area with the rotational axis oriented in a plane that lies outside a vertical plane perpendicular to the horizontal support surface. The sloped orientation of the rotational axis conserves vertical height. It makes it possible to place the rotating centrifuge components for access in a zone that lies between the knees and the chest of the intended user, when standing.
    Type: Grant
    Filed: September 28, 1995
    Date of Patent: August 20, 1996
    Assignee: Baxter International Inc.
    Inventor: Paul M. Di Perna
  • Patent number: 5529567
    Abstract: A blood processing assembly includes a centrifuge contained within a heated housing or chamber. A fail safe spill or splash detector is located within the inner wall of the housing. The detector includes a pair of parallel electrodes separated from each other from a small gap. The circuit detects a splash or droplet of liquid which conducts current between the electrodes.
    Type: Grant
    Filed: July 1, 1994
    Date of Patent: June 25, 1996
    Assignee: Baxter International Inc.
    Inventors: Ronald E. Toth, William H. Cork
  • Patent number: 5525218
    Abstract: A centrifuge provides simplify access to the processing chamber. In one arrangement, the processing chamber separates into a bowl and spool element to receive a disposable processing bag. In another arrangement, the processing chamber pivots between an operating position and an access position to provide improved access. The centrifuge also employs readily accessible holders for releasably retaining tubing that, in use, conveys fluid to and from the chamber. Though greatly accessible, the centrifuge operates without the need of complicated rotating seals and expensive disposable components.
    Type: Grant
    Filed: November 4, 1994
    Date of Patent: June 11, 1996
    Assignee: Baxter International Inc.
    Inventors: Warren P. Williamson, IV, Richard I. Brown
  • Patent number: 5494578
    Abstract: A system and method of separation of therapeutic components from blood. The system includes a dual member centrifuge and a disposable single use fluid transfer set. The set includes an elongated flexible separation chamber having an input port, a separated component output port and a residual fluid output port. The input port and the separated component output ports are located at opposite ends of the elongated separation chamber. The centrifuge includes a receiving chamber with a selectively formed annular slot therein. The separation chamber is positioned in the annularly shaped slot and rotated at a predetermined rotational velocity. Fluids such as whole blood flows through the separation chamber and are separated into various therapeutic components such as platelet rich plasma and residual concentrated red blood cells. Platelet rich plasma can be drawn off as the separated therapeutic component. An alternate two part transfer set provides for highly efficient platelet pheresis.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: February 27, 1996
    Assignee: Baxter International Inc.
    Inventors: Richard I. Brown, Sidney Smith, David E. Cerny, John T. Foley
  • Patent number: 5445593
    Abstract: A method and apparatus for the continuous conditioning of a cell suspension, more particularly whole blood, in order to obtain an erythrocyte concentrate which is returned to the patient by autotransfusion. In accordance with the invention there are three treatment stages, that is to say sedimentation of the cell suspension, the addition of washing solution to the cell concentrate and renewed sedimentation and separation of the washing solution.
    Type: Grant
    Filed: July 16, 1993
    Date of Patent: August 29, 1995
    Assignee: Fresenius AG
    Inventors: Wolfgang Biesel, Bernd Mathieu, Wolfram Weber
  • Patent number: 5370600
    Abstract: An orbital separator for separating lighter and heavier components of a mixture including a rotatable cylindrical separation container with an opening in the bottom, an upper inlet tube coaxial with the separation container for discharging a mixture into the separation container, a tubular outlet member communicating with the opening in the separation container bottom and extending coaxially upwardly in the separation container defining a moat area within the separation container lower portion, and a removable liner within the separation container moat area for collecting the heavier components of a mixture, the lighter components flowing out through the tubular outlet member.
    Type: Grant
    Filed: January 7, 1994
    Date of Patent: December 6, 1994
    Assignee: Bardyne, Inc.
    Inventors: Ernest C. Fitch, Jr., Ing T. Hong
  • Patent number: 5368542
    Abstract: An apparatus and method for the separation of a predetermined type of microscopic unit (e.g., islets of Langerhans) from a given medium (e.g., pancreatic digest) by centrifuging in a substantially continuous density gradient. In one embodiment, a substantially continuous density gradient solution is provided to a flexible processing bag appropriately positioned within an upper chamber of a rotating variable volume centrifuge. The solution having a plurality of the desired microscopic units therein is loaded onto the gradient and such units migrate to a particular radial position within the gradient based upon the density of such units. Once appropriately separated by the formation of regions, a fluid is provided to a lower chamber of the centrifuge bowl during continued rotation thereof to sequentially remove fractions from the processing bag from an inward location to an outward location, at least one of which fractions includes the band of the desired microscopic units.
    Type: Grant
    Filed: January 12, 1994
    Date of Patent: November 29, 1994
    Assignee: Cobe Laboratories, Inc.
    Inventors: John D. McMannis, Nicholas London
  • Patent number: 5360542
    Abstract: A centrifuge provides simplify access to the processing chamber. In one arrangement, the processing chamber separates into a bowl and spool element to receive a disposable processing bag. In another arrangement, the processing chamber pivots between an operating position and an access position to provide improved access. The centrifuge also employs readily accessible holders for releasably retaining tubing that, in use, conveys fluid to and from the chamber. Though greatly accessible, the centrifuge operates without the need of complicated rotating seals and expensive disposable components.
    Type: Grant
    Filed: November 2, 1993
    Date of Patent: November 1, 1994
    Assignee: Baxter International Inc.
    Inventors: Warren P. Williamson, IV, Richard I. Brown
  • Patent number: 5356365
    Abstract: A temperature-controlled centrifuge in which a heat exchanger is attached to the bottom portion of the centrifuge bowl to remove heat from the bowl and materials within the bowl interacting therewith. In one embodiment, a heat exchange plate having a plurality of substantially annular channels is appropriately attached to the bottom of the centrifuge bowl and has a surface which is thus substantially coextensive therewith. Each of these channels are positioned at different radial distances from the central axis of the heat exchange plate and each extends substantially about such axis. An appropriate heat transfer medium may thus be circulated through each of these channels to thereby substantially control a temperature across the entire bottom of the bowl. The heat transfer medium may be provided to each of the channels by a common feed inlet which also allows for the use of flow regulators where appropriate, and the heat transfer medium may also thus be removed from the channels by a common dump line.
    Type: Grant
    Filed: February 25, 1994
    Date of Patent: October 18, 1994
    Assignee: Cobe Laboratories, Inc.
    Inventor: Mark J. Brierton
  • Patent number: 5316540
    Abstract: An apparatus and method for the separation of a predetermined type of microscopic unit (e.g., islets of Langerhans) from a given medium (e.g., pancreatic digest) by centrifuging in a substantially continuous density gradient. In one embodiment, a substantially continuous density gradient solution is provided to a flexible processing bag appropriately positioned within an upper chamber of a rotating variable volume centrifuge. The solution having a plurality of the desired microscopic units therein is loaded onto the gradient and such units migrate to a particular radial position within the gradient based upon the density of such units. Once appropriately separated by the formation of regions, a fluid is provided to a lower chamber of the centrifuge bowl during continued rotation thereof to sequentially remove fractions from the processing bag from an inward location to an outward location, at least one of which fractions includes the band of the desired microscopic units.
    Type: Grant
    Filed: January 13, 1993
    Date of Patent: May 31, 1994
    Assignee: Cobe Laboratories
    Inventors: John D. McMannis, Nicholas London
  • Patent number: 5304348
    Abstract: An analytical rotor which comprises a receptacle for receiving a post on a centrifuge and a sealed rigid container in the rotor body proximate to the receptacle is provided. The seal on the container is opened when the post is inserted in the receptacle, thereby releasing a liquid in the container. The seal is preferably opened through the displacement of the container caused by positioning of the rotor on the centrifuge post.
    Type: Grant
    Filed: February 11, 1992
    Date of Patent: April 19, 1994
    Assignee: Abaxis, Inc.
    Inventors: Tammy L. Burd, Carol T. Schembri
  • Patent number: 5295943
    Abstract: An adapter for a centrifuge tube comprises two adapter segments, each of which has an exterior surface and a mating surface thereon. Each segment has a pair of indentations in the mating surface. When the segments are joined along their mating surfaces the indentations cooperate to define a pair of recesses therein. Each recess so defined is configured to surround totally a centrifuge tube disposed therein. Each recess has an axis extending therethrough, with the axes of the recesses being collinear. The collinear axes of the recesses are aligned parallel to the axis of rotation of the rotor, and preferably also align collinearly with the axis of the rotor cavity in which the adapter is disposed. Each adapter segment is fabricated of a material that has sufficient strength to withstand the vertical forces created by the pressure of a liquid under centrifugation.
    Type: Grant
    Filed: May 27, 1993
    Date of Patent: March 22, 1994
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: William A. Romanauskas, Edward T. Sheeran, Jr.
  • Patent number: 5252208
    Abstract: A liner or wrap for use in the scroll or discharge housing of a centrifugal separator device. The wrap comprises a one-piece, elongated strip of material which is releasably secured to the interior wall which is replaceable in the event of excessive wear. The wrap is compressible and can be placed into the separator device without having to remove the blade assemblies. The releasable wrap is seated against the discharge housing wall contiguous to blades which are rotatable in the discharge housing.
    Type: Grant
    Filed: February 5, 1992
    Date of Patent: October 12, 1993
    Assignee: Inter-Source Recovery Systems, Inc.
    Inventor: William D. Nemedi
  • Patent number: 5230797
    Abstract: A centrifuge bowl of the type having a shell including a peripheral wall and a cast inner liner attached to the inside surface of the peripheral wall is modified by the provision of a plurality of punched channel portions which extend inwardly into the bowl from peripheral wall to define a U-shaped channel with severed ends. During the casting process the casting plastics material extends into the recess behind each channel portion and thus when set forms an insert portion which anchors the liner to the channel portion and thus to the peripheral wall. Openings for the entry of fluidizing water are then drilled through the insert portion from the outside of the shell through one end of the channel portion and through the liner into the interior of the bowl.
    Type: Grant
    Filed: December 11, 1991
    Date of Patent: July 27, 1993
    Inventor: Benjamin V. Knelson
  • Patent number: 5224921
    Abstract: A device and method are provided for separating mononuclear cells from red blood cell depleted plasma in a centrifuge blood cell separator. The device includes an inlet for receiving plasma, an area for receiving mononuclear cells, and an outlet for receiving mononuclear cell depleted plasma. The distance and flow path between the inlet and outlet being so constructed and arranged as to cause mononuclear cells to sediment out into the area for receiving the mononuclear cells and causing at least 66% of the platelets contained in the plasma to flow to and through the outlet.
    Type: Grant
    Filed: May 31, 1990
    Date of Patent: July 6, 1993
    Assignee: Baxter International Inc.
    Inventors: T. Michael Dennehey, Joseph C. West, Jr.
  • Patent number: 5217427
    Abstract: A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer arcuate wall plus an inner circumferential wall, spaced from the outer wall, to define a arcuate slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.
    Type: Grant
    Filed: October 4, 1991
    Date of Patent: June 8, 1993
    Assignee: Baxter International Inc.
    Inventor: Herbert M. Cullis
  • Patent number: 5217426
    Abstract: A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer arcuate wall plus an inner circumferential wall, spaced from the outer wall, to define a arcuate slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.
    Type: Grant
    Filed: August 14, 1991
    Date of Patent: June 8, 1993
    Assignee: Baxter International Inc.
    Inventors: David V. Bacehowski, Herbert M. Cullis, Armand R. VanBaelen
  • Patent number: 5160310
    Abstract: In a centrifuge rotor there is formed a separation chamber (4) having an inlet (24) for a mixture of components to be separated and two outlets (21,23) for the respective separated components. A partition (7) is arranged to divide the separation chamber (4) in two elongated compartments (29, 30) situated at different distances form the rotor axis. A displacement member is arranged to displace the separated heavy component in the circumferential direction of the rotor through the radially outer one of said compartments to and out through the outlet (23) for heavy component.
    Type: Grant
    Filed: July 29, 1991
    Date of Patent: November 3, 1992
    Assignee: Centritech AB
    Inventor: Carl Yhland
  • Patent number: 5158749
    Abstract: An insert beaker for centrifuges for centrifuging blood, having a blood bag placed in the insert beaker in association with a positive displacement body that acts upon the insert beaker from outside, the blood bag communicating via connecting hoses with at least one other blood bag inside the centrifuge. The insert beaker (1) is made with two pivotable shell halves (2, 3) joined together, and retaining elements for the blood bag to be placed between the shell halves (2, 3) is disposed on the top of the shell halves (2, 3).
    Type: Grant
    Filed: March 12, 1990
    Date of Patent: October 27, 1992
    Assignee: Andreas Hettich
    Inventor: Gunter Eberle
  • Patent number: 5114396
    Abstract: Thawed glycerolized red blood cells are washed in a system (1) of closed collapsible containers of flexible material which are positioned concentrically in a centrifuge rotor. The blood cells are held in an annular primary container (2) into which wash liquid is centrifugally fed from a c entral container (3) and from which supernatant is expressed into a central waste container (4) while the primary container is being compressed as a result of centrifugal action on an elastic body (24) in the rotor. A container assembly (1) for use in carrying out the washing comprises an annular collapsible primary container (2), a collapsible circular closed wash liquid container (3), a collapsible circular, closed waste container (4), and valve controlled conduits for passing liquid from the wash liquid container into the primary container and from the primary container into the waste container.
    Type: Grant
    Filed: June 18, 1991
    Date of Patent: May 19, 1992
    Assignee: Omega Medicinteknik AB
    Inventors: Peter Unger, Eric Westberg
  • Patent number: 5104526
    Abstract: A system and method of separation of therapeutic components from blood. The system includes a dual member centrifuge and a disposable single use fluid transfer set. The set includes an elongated flexible separation chamber having an input port, a separated component output port and a residual fluid output port. The input port and the separated component output ports are located at opposite ends of the elongated separation chamber. The centrifuge includes a receiving chamber with a selectively formed annular slot therein. The separation chamber is positioned in the annularly shaped slot and rotated at a predetermined rotational velocity. Fluids such as whole blood flows through the separation chamber and are separated into various therapeutic components such as platelet rich plasma and residual concentrated red blood cells. Platelet rich plasma can be drawn off as the separated therapeutic component. An alternate two part transfer set provides for highly efficient platelet pheresis.
    Type: Grant
    Filed: May 26, 1989
    Date of Patent: April 14, 1992
    Assignee: Baxter International Inc.
    Inventors: Richard I. Brown, Sidney Smith, David E. Cerny, John T. Foley
  • Patent number: 5078671
    Abstract: A centrifugal processing system and method introduces fluid to be processed into a centrifugation chamber, while directing the fluid away from the region of the chamber where the largest centrifugal (or "G") forces exist. The fluid is also conveyed into the force field as a generally uniform stream having reduced turbulence or being essentially free of turbulence. The system and method thereby establish, upon the entry of a high velocity fluid stream into the centrifugal field, non-turbulent and uniform flow conditions conducive to effective separation. The system and method also direct the fluid in a way the maximizes the effective surface area of the centrifugation chamber for separation. Effective separation can thereby be achieved at high inlet flow rates.
    Type: Grant
    Filed: October 12, 1990
    Date of Patent: January 7, 1992
    Assignee: Baxter International Inc.
    Inventors: T. Michael Dennehey, Joseph C. West, Jr.
  • Patent number: 5076911
    Abstract: A system and method of separation of therapeutic components from blood. The system includes a dual member centrifuge and a disposable single use fluid transfer set. The set includes an elongated flexible separation chamber having an input port, a separated component output port and a residual fluid output port. The input port and the separated component output ports are located at opposite ends of the elongated separation chamber. The centrifuge includes a receiving chamber with a selectively formed annular slot therein. The separation chamber is positioned in the annularly shaped slot and rotated at a predetermined rotational velocity. Fluids such as whole blood flows through the separation chamber and are separated into various therapeutic components such as platelet rich plasma and residual concentrated red blood cells. Platelet rich plasma can be drawn off as the separated therapeutic component. An alternate two part transfer set provides for highly efficient platelet pheresis.
    Type: Grant
    Filed: March 27, 1991
    Date of Patent: December 31, 1991
    Assignee: Baxter International Inc.
    Inventors: Richard J. Brown, Sidney Smith, David E. Cerny, John T. Foley
  • Patent number: 5067939
    Abstract: A rotating bowl decanter centrifuge including a clarifier section and a beach section for separating a lighter phase from a heavier phase. The beach section includes a conveyor for conveying the heavier phase toward the exterior of the centrifuge. The centrifuge is without a conveyor in the effluent discharge end of the clarifier section. In a preferred embodiment, the clarifier section has an outward incline angle so that the clarifier wall bends away from the bowl's rotational axis. The beach section includes an inwardly inclined outer wall which bends towards the rotational axis of the bowl. It is preferred that the outward incline angle in the clarifier section be on the order of 5.degree. or less.
    Type: Grant
    Filed: March 21, 1990
    Date of Patent: November 26, 1991
    Assignee: Bird Machine Company
    Inventor: Ascher H. Shapiro
  • Patent number: 5037373
    Abstract: A centrifugal solids-liquids separator comprises a rotatable hollow centrifuge drum at least a part of which is tapered, and which is rotatable about its axis, means for introducing a slurry of solids and liquids to be separated at a point along the length of the drum spaced from a wider end so that rotation of the drum tends to cause migration of the slurry towards the said wider end, and scraper conveyor means rotatable about an axis coincident with that of the drum and at a relative speed which is low in relation to the absolute speed of the drum, the scraper conveyor means being so mounted that they act in direct contact with the inside surface of the drum so as to displace solids contacted thereby towards the narrow end of the drum against the axial force induced by the rotation.
    Type: Grant
    Filed: November 2, 1989
    Date of Patent: August 6, 1991
    Assignee: Richard Mozley Limited
    Inventor: Richard H. Mozley
  • Patent number: 5006103
    Abstract: A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer circumferential wall plus an inner circumferential wall, spaced from the outer wall, to define a circumferential slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.
    Type: Grant
    Filed: January 11, 1990
    Date of Patent: April 9, 1991
    Assignee: Baxter International Inc.
    Inventors: David V. Bacehowski, Herbert M. Cullis, Armand R. Van Baelen
  • Patent number: 4983156
    Abstract: A centrifugal separator for extracting heavy metals from a slurry comprises a centrifuge bowl having an inwardly facing surface over which the slurry runs. A dam at a discharge end of the surface forms a shallow layer of particles which separate preferentially the heavy metals. The surface includes a portion formed by a plurality of annular membrane portions spaced axially and separated by radial rings extending from the surface to a supporting metal bowl. The membranes are deflated or retracted to gradually form annular cups for receiving the separated metals. The membranes are then inflated to discharge the collected materials while the feed is temporarily halted and the bowl continues to rotate.
    Type: Grant
    Filed: July 3, 1989
    Date of Patent: January 8, 1991
    Inventor: Benjamin Knelson
  • Patent number: 4981585
    Abstract: A disk shaped cassette for centrifugal fluid separation, particularly blood separation, and a drive system for high speed rotation of the cassette. The cassette is driven at speeds which permit very rapid separation of the blood in times on the order of seven (7) to twenty (20) seconds by an automated control. The cassette is supported by a flexible support coupling and mounting system that permits the entire rotating mass to spin about the center of mass unique to the particular cassette as filled. The cassette typically includes a peripheral collection chamber which may be either annular, lobed or channel shaped. A cassette enabled to hold plural separation tubes is also shown. A gel can be placed in the cassette with a density between the fluid components to be separated and after centrifuging maintains the component separation that centrifuging creates.
    Type: Grant
    Filed: June 28, 1989
    Date of Patent: January 1, 1991
    Assignee: Norfolk Scientific, Inc.
    Inventors: Thomas F. Kelley, Robert L. Scott
  • Patent number: 4944874
    Abstract: A centrifugal filter separator includes a detachable tubular screen disposed between an annular filter and the inner peripheral surface of a basket, the screen having an annular flange detachably connected to an open end of the basket from the outside of the basket. The centrifugal separator having such detachable screen is applicalbe to centrifugal separation of various materials.
    Type: Grant
    Filed: October 25, 1988
    Date of Patent: July 31, 1990
    Assignee: Kabushiki Kaisha Okawara Seisakusho
    Inventors: Masaru Kobayashi, Sumio Kawai
  • Patent number: 4940543
    Abstract: An apparatus and method of separating a component from a collected quantity of fluid. The apparatus includes a dual member centrifuge and an associated fluid flow transfer set. The transfer set has a collection container in which a quantity of fluid can be initially accumulated. The collection container is formed as a disk-shaped plastic member with an elongated generally radially extending barrier member formed therein. A component collection container is in fluid flow communication with the disk-shaped container. The method provides for centrifugation of the collection container in the dual member centrifuge thereby separating out the selected fluid component. The component can then be pumped out of the collection container into the component accumulation container. The residual fluid can be sealed in the collection container for later use. The component collection container can be separated and sealed also for later use.
    Type: Grant
    Filed: November 30, 1988
    Date of Patent: July 10, 1990
    Assignee: Baxter International Inc.
    Inventors: Richard I. Brown, David E. Cerny, John T. Foley, Joseph C. West, Jr.
  • Patent number: 4936820
    Abstract: A centrifugal processing system for cultured cellular suspensions comprises a reservoir for pooling a desired volume of the cellular suspension from a plurality of individual containers in which the cellular suspension have been cultured. A centrifugation chamber is provided operative in response to centrifugal force for separating the cellular suspension into a cellular component and a supernatant. Fluid is conveyed from the reservoir into the centrifugation chamber at a high flow rate exceeding 1 liter per minute. The cellular component and supernatant are collected from the centrifugation chamber.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: June 26, 1990
    Assignee: Baxter International Inc.
    Inventors: T. Michael Dennehey, Stanley J. Pernic, Joseph C. West, Jr.
  • Patent number: 4934995
    Abstract: A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer arcuate wall plus an inner circumferential wall, spaced from the outer wall, to define a arcuate slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.
    Type: Grant
    Filed: August 12, 1977
    Date of Patent: June 19, 1990
    Assignee: Baxter International Inc.
    Inventor: Herbert M. Cullis
  • Patent number: 4909949
    Abstract: A bridge is attachable to and mountable upon the upper edge of a centrifuge cup for suspending a blood collection bag within the cavity of the centrifuge cup during centrifugation of the collected blood. The bridge includes structure for supporting the bridge upon an expressor to permit expressing the centrifuged blood from the bridge suspended blood collection bag.
    Type: Grant
    Filed: October 26, 1987
    Date of Patent: March 20, 1990
    Assignee: Engineering & Research Associates
    Inventors: Daniel C. Harmony, Bradley T. Noble
  • Patent number: 4892668
    Abstract: Isolation of a quantity of blood within a fold of a blood collection bag is prevented during centrifugation by applying a laterally oriented force against the blood collection bag to pressurize it and encourage unfolding of any folds. The laterally oriented force is generated by the apparent weight increase of the blood collection bag during centrifugation.
    Type: Grant
    Filed: October 5, 1988
    Date of Patent: January 9, 1990
    Assignee: Engineering & Research Associates, Inc.
    Inventors: Daniel C. Harmony, Bradley T. Noble
  • Patent number: 4854933
    Abstract: A plasma separator for receiving a blood sample includes a central chamber of inverted conical shape and an outer annular chamber connected to the central chamber by a downwardly inclined passageway. The separator is designed to be rotated at high speed about a vertical axis so that red blood cells in the sample migrate down the passageway and into the outer chamber, leaving clear plasma in the central chamber that can then be removed by pipette.
    Type: Grant
    Filed: October 6, 1987
    Date of Patent: August 8, 1989
    Inventor: John D. Mull
  • Patent number: 4850952
    Abstract: After separation and during centrifuging a separated blood component is transferred from a source reservoir (2) into a tube (4) oriented against a centrifugal gradient. A cap (34) converts the separated layer from the reservoir into a columnar body and the centrifugal gradient prevents mixing of the columnar body in the tube (4) during further centrifuging. In one embodiment the tube has a volume sufficient to hold a desired fractional component from the source reservoir, and a diameter small enough to prevent mixing of the component when the gradient is removed. A support (69) holds the conduit wound about a spool transverse to the iso-g-lines of the centrifuge. The support (69) may be removably affixed to the cap (34). In a preferred embodiment the source reservoir (2) has a flexible wall, and pressure of the wall against an elevation (29) maintains pressure in the fluid system.
    Type: Grant
    Filed: May 8, 1987
    Date of Patent: July 25, 1989
    Inventors: Carl G. Figdor, Willy S. Bont
  • Patent number: 4846974
    Abstract: A disk shaped cassette for centrifugal fluid separation, particularly blood separation, and a drive system for high speed rotation of the cassette. The cassette is driven at speeds which permit very rapid separation of the blood in times on the order of seven (7) to twenty (20) seconds by an automated control. The cassette is supported by a flexible support coupling and mounting system that permits the entire rotating mass to spin about the center of mass unique to the particular cassette as filled. The cassette typically includes a peripheral collection chamber which may be either annular, lobed or channel shaped. A cassette enabled to hold plural separation tubes is also shown. A gel can be placed in the cassette with a density between the fluid components to separated and after centrifuging maintains the component separation that centrifuging creates.
    Type: Grant
    Filed: November 14, 1985
    Date of Patent: July 11, 1989
    Assignee: Norfolk Scientific, Inc.
    Inventors: Thomas F. Kelley, Robert L. Scott
  • Patent number: 4846780
    Abstract: A centrifugal method and apparatus capable of separating a fluid stream composed of a plurality of components with differing specific gravities. The stream contemplated for separation is that of a producing oil well with components of oil, water, natural gas, and particulates. The method and apparatus use centrifugal forces to separate the gaseous, solid, and liquid components from each other. After separation is completed, detector and sensor arrangements are used to maintain liquid levels in the separator and to control the removal of the individual separated fluids from the apparatus.
    Type: Grant
    Filed: August 10, 1988
    Date of Patent: July 11, 1989
    Assignee: Exxon Production Research Company
    Inventors: Jimmie G. Galloway, Lonny R. Kelley, Mark E. Ehrhardt, Tracy A. Fowler
  • Patent number: 4834890
    Abstract: A system and method of separation of therapeutic components from blood. The system includes a dual member centrifuge and a disposable single use fluid transfer set. The set includes an elongated flexible separation chamber having an input port, a separated component output port and a residual fluid output port. The input port and the separated component output ports are located at opposite ends of the elongated separation chamber. The centrifuge includes a receiving chamber with a selectively formed annular slot therein. The separation chamber is positioned in the annularly shaped slot and rotated at a predetermined rotational velocity. Fluids such as whole blood flows through the separation chamber and are separated into various therapeutic components such as platelet rich plasma and residual concentrated red blood cells. Platelet rich plasma can be drawn off as the separated therapeutic component. An alternate two part transfer set provides for highly efficient platelet pheresis.
    Type: Grant
    Filed: January 30, 1987
    Date of Patent: May 30, 1989
    Assignee: Baxter International Inc.
    Inventors: Richard I. Brown, Sidney Smith, David E. Cerny, John T. Foley
  • Patent number: 4806252
    Abstract: An apparatus and method of separating a component from a collected quantity of fluid. The apparatus includes a dual member centrifuge and an associated fluid flow transfer set. The transfer set has a collection container in which a quantity of fluid can be initially accumulated. The collection container is formed as a disk-shaped plastic member with an elongated generally radially extending barrier member formed therein. A component collection container is in fluid flow communication with the disk-shaped container. The method provides for centrifugation of the collection container in the dual member centrifuge thereby separating out the selected fluid component. The component can then be pumped out of the collection container into the component accumulation container. The residual fluid can be sealed in the collection container for later use. The component collection container can be separated and sealed also for later use.
    Type: Grant
    Filed: January 30, 1987
    Date of Patent: February 21, 1989
    Assignee: Baxter International Inc.
    Inventors: Richard I. Brown, David E. Cerny, John T. Foley, Joseph C. West, Jr.
  • Patent number: 4790807
    Abstract: The invention relates to a centrifuge arrangement having a centrifuge rotor comprising a drive disc (18) connected to a drive source. Furthermore, the centrifuge rotor comprises at least one separation container (1, 32) which comprises a separation passage (6) and a separation chamber (9) whose outlet and inlet passages lead to the center of the drive disc (18). Advantageously, the separation container (1, 32) is made as self-supporting part of rigid or semi-rigid but flexible material and this makes it possible to insert said container easily into the drive disc (18) and in addition provides advantages in the production of the centrifuge arrangement according to the invention.
    Type: Grant
    Filed: September 23, 1987
    Date of Patent: December 13, 1988
    Assignee: Fresenius AG
    Inventors: Hans-Jurgen Neumann, Wolfram Weber
  • Patent number: 4776833
    Abstract: A centrifugal separator for use for example with the extraction of gold of the type comprising a bowl with a plurality of rings on the inner peripheral surface between which are provided openings for the injection of water between the rings into the interior of the bowl is modified by a number of further features. Thus firstly the rings and recesses between the rings are molded from a plastics inner which is cast in place within an outer rigid bowl. The openings are formed by punched depressions in the outer wall formed prior to the casting and then drilled subsequent to the casting to form a tangential opening. The shape of the recesses defines sides tapered outwardly toward a flat base at a shallow angle of the order of 15 degrees with the width of the base wider than the width of the injection openings.
    Type: Grant
    Filed: October 23, 1986
    Date of Patent: October 11, 1988
    Inventor: Benjamin V. Knelson
  • Patent number: 4767397
    Abstract: Apparatus for the centrifugal fractionation and component-isolation of liquid material has a nonflexing radially-movable pressure panel disposed between a first liquid container stacked radially in front of a second liquid container. The two containers are at the same interval pressure during centrifugation, and the pressure panel avoids radial distortion of the back wall of the first container. The liquid container structure can incorporate the pressure panel. Alternatively, the panel can be part of the centrifugal separating instrument.
    Type: Grant
    Filed: March 9, 1987
    Date of Patent: August 30, 1988
    Assignee: Damon Corporation
    Inventors: Rudolph Hohenberg, Carl G. Figdor, Willy S. Bont
  • Patent number: 4753739
    Abstract: A blood bag support system is described which is very useful for supporting a blood bag in a centrifuge. The support system includes two upright support members and horizontal connecting means extending between the upright supports. A blood bag is suspended from the connecting means. The support system is balanced so as to avoid vortexing or mixing inside the blood bag during centrifuging. The support system holds up the ports at the top of the bag, enabling red blood cells in the ports to be forced downwardly during centrifuging. This prevents contamination of blood components with red blood cells.
    Type: Grant
    Filed: January 27, 1986
    Date of Patent: June 28, 1988
    Assignee: Engineering & Research Associates
    Inventor: Bradley T. Noble