Metal-containing Organic Compounds Patents (Class 506/21)
-
Patent number: 10094831Abstract: Disclosed herein are a norovirus detection sensor and an electrochemical sensing method using the sensor. Specifically, in the norovirus detection sensor including a bioreceptor and a signal detector, a three-dimensional gold nanosurface electrode is used as a substrate, and the bioreceptor employs concanavalin A as a sample capture agent immobilized to the substrate and capable of binding to norovirus. Therefore, the norovirus detection sensor has improved sensitivity by employing the three-dimensional gold nanosurface electrode having a wide surface area. In addition, the norovirus detection sensor has effects of reducing manufacturing costs using a non-antibody material, i.e., concanavalin A which is inexpensive and readily available.Type: GrantFiled: December 29, 2014Date of Patent: October 9, 2018Assignees: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY, KOREA BASIC SCIENCE INSTITUTE, INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITYInventors: Sung Yang, Du-Woon Kim, Joseph Kwon, Sung-A Hong, Jong-Soon Choi, Heemin Lee
-
Publication number: 20150094234Abstract: This invention relates to a method for characterizing and/or determining a samples, particularly in the aid of lanthanide(III) ions and ligands including an aromatic structure and 2-5 chelating heteroatoms. The invention relates also to an array for characterizing and/or determining a samples utilizing the properties of lanthanide(III) chelates.Type: ApplicationFiled: April 23, 2013Publication date: April 2, 2015Inventors: Harri Härmä, Sari Pihlasalo
-
Patent number: 8859469Abstract: A protein chip including at least a substrate having a plurality of steps which are regularly arranged on one surface thereof; a plurality of metallic microstructures arranged in the steps; and a lipid vesicle in which an outer surface thereof is modified by a functional group and a protein is present in a lipid bilayer thereof. The metallic microstructures and the lipid vesicle are bound via the functional group to provide the protein on the substrate.Type: GrantFiled: January 11, 2008Date of Patent: October 14, 2014Assignees: Nippon Telegraph and Telephone Corporation, Isis Innovation LimitedInventors: Chandra Sekar Ramanujan, Koji Sumitomo, Maurits R. R. de Planque, Hiroki Hibino, John F. Ryan, Keiichi Torimitsu
-
Publication number: 20130210679Abstract: The present invention relates to method for preparing a metal nanoparticle organic composite film, preferably a metal nanoparticle organic composite film of a chemical sensing device, to a metal nanoparticle organic composite film obtained by said method, and to a chemical sensing device comprising a metal nanoparticle organic composite film or an array of different metal nanoparticle organic composite films obtained by said method.Type: ApplicationFiled: August 16, 2012Publication date: August 15, 2013Applicant: Sony CorporationInventors: Yvonne JOSEPH, Isabelle Raible, Nadejda Krasteva, Gabriele Nelles
-
Patent number: 8481746Abstract: A novel process of preparing tridentate ligands containing a diarylphosphine electron donating group are disclosed. Use of this process for preparing a combinatorial library of such tridentate ligands and of organometallic complexes containing same is also disclosed. Further disclosed are novel diarylphosphine-containing compounds that can serve as tridentate ligands (e.g., pincer ligands), combinatorial libraries of such tridentate ligands, organometallic complexes containing these ligands (e.g., pincer complexes), and combinatorial libraries of such complexes. Methods utilizing these libraries for screening for candidate organometallic catalysts are also disclosed.Type: GrantFiled: May 14, 2009Date of Patent: July 9, 2013Assignee: Technion Research & Development Foundation LimitedInventors: Mark Gandelman, Elaine Melissa Schuster
-
Patent number: 8372949Abstract: The present invention includes methods for selective binding of inorganic materials and the compositions that made up of the selecting agent and the target materials. One form of the present invention is a method for selecting crystal-binding peptides with binding specificity including the steps of contacting one or more amino acid oligomers with one or more single-crystals of a semiconductor material so that the oligomers may bind to the crystal and eluting the bound amino acid oligomers from the single-crystals.Type: GrantFiled: July 24, 2007Date of Patent: February 12, 2013Assignee: The Board of Regents, The University of Texas SystemInventor: Angela M. Belcher
-
Publication number: 20120149601Abstract: Methods, systems and related apparatus for fluorescence-based detection of various nitro and peroxide compounds.Type: ApplicationFiled: March 21, 2008Publication date: June 14, 2012Inventors: Michael J. Knapp, Meaghan Germain
-
Publication number: 20120122706Abstract: Disclosed herein is an array, including a plurality of sensing units, each of which contains a mixture of porphyrin compounds, and which are arranged in a predetermined pattern. The array is advantageous in that it is possible to qualitatively analyze various mixture samples without performing complicated processes of separation and analysis.Type: ApplicationFiled: November 16, 2011Publication date: May 17, 2012Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventor: Hyo-Bong Hong
-
Publication number: 20100292100Abstract: A novel process of preparing tridentate ligands containing a diarylphosphine electron donating group are disclosed. Use of this process for preparing a combinatorial library of such tridentate ligands and of organometallic complexes containing same is also disclosed. Further disclosed are novel diarylphosphine-containing compounds that can serve as tridentate ligands (e.g., pincer ligands), combinatorial libraries of such tridentate ligands, organometallic complexes containing these ligands (e.g., pincer complexes), and combinatorial libraries of such complexes. Methods utilizing these libraries for screening for candidate organometallic catalysts are also disclosed.Type: ApplicationFiled: May 14, 2009Publication date: November 18, 2010Applicant: Technion Research & Development Foundation Ltd.Inventors: Mark GANDELMAN, Elaine Melissa SCHUSTER
-
Publication number: 20100292084Abstract: A novel process of preparing tridentate ligands containing one or more of a diarylphosphine and/or dialkylphosphine electron donating groups are disclosed. Use of this process for preparing a combinatorial library of such tridentate ligands and of organometallic complexes containing same is also disclosed. Further disclosed are novel diarylphosphine-containing and dialkylphosphine-containing compounds that can serve as tridentate ligands (e.g., pincer ligands), combinatorial libraries of such tridentate ligands, organometallic complexes containing these ligands (e.g., pincer complexes), and combinatorial libraries of such complexes. Methods utilizing these libraries for screening for candidate organometallic catalysts are also disclosed. Novel precursor molecules useful for preparing the tridentate ligands and processes of preparing same are also disclosed.Type: ApplicationFiled: May 13, 2010Publication date: November 18, 2010Applicant: Technion Research & Development Foundation Ltd.Inventors: Mark GANDELMAN, Elaine Melissa Schuster, Gennady Nisnevich
-
Publication number: 20100188075Abstract: A biomolecular sensor system includes an array of magnetoresistive nanosensors designed for sensing biomolecule-conjugated superparamagnetic nanoparticles. Materials and geometry of each sensor element are designed for optimized sensitivity. The system includes magnetic field generators to apply forces to superparamagnetic nanoparticles for 1) nanoparticle manipulation, 2) sensor magnetic biasing, 3) magnetic pull-off measurement for differentiation against non-specific association, and 4) removal of all particles from the sensor array surface.Type: ApplicationFiled: July 26, 2006Publication date: July 29, 2010Inventors: Dmitri Litvinov, Richard Wilson
-
Patent number: 7662750Abstract: The present invention relates to 1,4-disubstituted naphthalene scaffold compounds and other closely related scaffold compounds. The present invention also relates to combinatorial libraries of such compounds. In addition, the present invention relates to a method of identifying a protein-protein interaction antagonist. The method first involves providing a compound as described herein. Next, the compound is contacted with interacting proteins of a protein-protein interaction target complex, whereby the compound is allowed to compete with the interacting proteins. Then, the activity of the compound for inhibiting formation of the protein-protein interaction target complex is measured. Finally, the compound that inhibits formation of the protein-protein interaction target complex is identified as a protein-protein interaction antagonist. Also disclosed is a method for modulating a protein-protein interaction.Type: GrantFiled: December 6, 2004Date of Patent: February 16, 2010Assignees: The Research Foundation of State University of New York, Roswell Park Cancer InstituteInventors: David G. Hangauer, Tao Ji, Madison Lee, Steven Pruitt
-
Patent number: 7651979Abstract: The present invention relates to novel coordination complexes, methods for synthesizing and identifying coordination complexes, using combinatorial techniques, and assaying their activity.Type: GrantFiled: August 27, 2004Date of Patent: January 26, 2010Assignee: Massachusetts Institute of TechnologyInventors: Stephen J. Lippard, Christopher J. Ziegler
-
Publication number: 20090036537Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.Type: ApplicationFiled: December 29, 2004Publication date: February 5, 2009Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Kenneth N. Raymond, Stephane Petoud, Jide Xu
-
Publication number: 20080176768Abstract: A method of creating a metal nanoparticle hydrogel biological array comprises placing a plurality of metal nanoparticles in each of a plurality of wells on a substrate, and placing a biomolecular probe material into the plurality of wells. Hydrogel precursors are placed in each of the plurality of wells; and are polymerized to form hydrogel such that the metal nanoparticles are embedded in the hydrogel.Type: ApplicationFiled: January 23, 2007Publication date: July 24, 2008Inventors: Yuan Zheng, Jicang Zhou, Leon Xu
-
Publication number: 20080125331Abstract: A coating composition for making a protein microarray, the composition comprising a gelling agent or a precursor to a gelling agent, and microspheres; the microspheres containing a dye represented by the Formula (1): wherein: R1=one or more substitutent selected from the group of H, chloro, alkoxycarbonyl, arylsulfamoyl, or alkylsulfamoyl; R2=one or more substituent selected from the group of H, carboxamido, or alkoxycarbonyl; R3=one or more substituent selected from the group of H, chloro, substituted or unsubstituted alkyl, aryl, carboxamido, or alkoxycarbonyl.Type: ApplicationFiled: November 27, 2007Publication date: May 29, 2008Inventors: Krishnan Chari, Tiecheng A. Qiao, Donald R. Diehl, Samuel Chen, Kevin W. Williams, David A. Stegman