Library Containing Only Organic Compounds Patents (Class 506/15)
  • Patent number: 11434448
    Abstract: A perfume composition having controlled release of phytoncides in an atmosphere in order to generate an air condition resembling the air environment of a forest is provided. The perfume composition includes a) at least about 0.6% by weight of at least one phytoncide; and b) a perfume mixture including (i) at least one solvent; and (ii) at least one fragrance ingredient. At least about 25% by weight of the at least one phytoncide is selected from the group consisting of pinene alpha, pinene beta and combinations thereof.
    Type: Grant
    Filed: October 27, 2020
    Date of Patent: September 6, 2022
    Assignee: Givaudan S.A.
    Inventors: Philippe Blondeau, Alice Bresson Boil
  • Patent number: 11390586
    Abstract: The present disclosure concerns use of compounds of formula I, or salts thereof, as reactive matrices for desorption and laser ablation ionization spectrometry. The disclosure further concerns compounds of formula II, or salts thereof, and use of compounds of formula II or III, or salts thereof.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: July 19, 2022
    Inventors: Per Andrén, Luke Odell, Anna Nilsson, Mohammadreza Shariatgorji, Jonas Sävmarker
  • Patent number: 11370812
    Abstract: Provided herein are isotopically labeled reagents, including isotopically labeled small molecules and peptides, that can be used to detect and/or quantify ?-N-methylamino-L-alanine (BMAA) in a sample. The reagents can be used as stable isotope labeled standards in analytical methods, including in conjunction with mass spectrometry, to detect and/or quantify BMAA in a sample, such as a protein sample from a subject.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: June 28, 2022
    Assignee: North Carolina State University
    Inventors: David C. Muddiman, Philip L. Loziuk, Joshua G. Pierce, Gavin Williams, Yasamin Moazami
  • Patent number: 11326159
    Abstract: Various approaches for generating read-sets from nucleic acid molecules and segments and phasing are disclosed. Nucleic acids are assembled into complexes using binding moieties and exposed nucleic acid ends are tagged with nucleic acid tags. Read-sets can be generated from tagged nucleic acid molecules and segments. Physical linkage relationships between nucleic acid molecules and segments can be examined using the nucleic acid tags. Various approaches to generating read-sets and phasing are presented.
    Type: Grant
    Filed: April 4, 2016
    Date of Patent: May 10, 2022
    Assignee: The Regents of the University of California
    Inventor: Daniel S. Rokhsar
  • Patent number: 11117856
    Abstract: Disclosed herein are efflux pump inhibitors and pharmaceutical compositions comprising the same. The efflux pump inhibitors may be used in methods of preventing antibiotic resistance in a subject, and in methods of treating a bacterial infection in a subject. The efflux pump inhibitor may be co-administered with an antibiotic.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: September 14, 2021
    Inventors: Renee Fleeman, Radleigh G. Santos, Marcello Angelo Giulianotti, Lindsey Shaw
  • Patent number: 10913719
    Abstract: Disclosed is a process for preparing a compound of Formula 1, from a compound of Formula 2 wherein X, R1, R2, R3, R4, R5, n, R6, R7, G and W are as defined in the disclosure. Also disclosed are compounds of Formulae 2 and 4 wherein X, R1, R2, R3, R4, R5, n, R6, R7, G and W are as defined in the disclosure. Also disclosed is a process for preparing the compounds of Formulae 2 and 4.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: February 9, 2021
    Assignee: FMC Corporation
    Inventors: Thomas Paul Selby, Kanu Maganbhai Patel, Thomas Martin Stevenson
  • Patent number: 10800742
    Abstract: In accordance with one or more embodiments, the present invention provides a compound of formulas I, II, and III, for use in methods of inhibition of PBX1-DNA interaction in a mammalian cell or population of cells, and for use in the treatment of medical conditions including but not limited to cancers, developmental disorders, inflammatory disorders, autoimmune diseases, or neuro-degenerative disorders.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: October 13, 2020
    Assignee: The Johns Hopkins University
    Inventors: Tian-Li Wang, Ie-Ming Shih, Mark Vaal, Alexander Stoeck, Jin G. Jung
  • Patent number: 10697945
    Abstract: Provided is an amine group-derivatized composition including a Boc compound for liquid chromatography-mass spectrometry (LC-MS) analysis, and when the amine group-derivatized composition is used in analysis using reverse-phase LC-MS, it is possible to effectively analyze compounds including an amine group and an amino acid at a low cost in a short time.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: June 30, 2020
    Inventors: Yongsoo Choi, Jeongsook Shin, Cheol-Ho Pan, Sang Min Kim, Jung-Seok Yang, Kyungsu Kang, Sang Hoon Jung
  • Patent number: 10693073
    Abstract: The present specification relates to an organic electronic device including a fullerene derivative.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: June 23, 2020
    Assignee: LG CHEM, LTD.
    Inventors: Jaesoon Bae, Jaechol Lee, Jiyoung Lee, Doowhan Choi
  • Patent number: 10551387
    Abstract: A cancer cell detection method that makes it possible to perform imaging of cells in a living state and a dual detection method for cancer cells in which the aforementioned method is combined with a pre-existing dyeing method for cytodiagnosis. The method uses living body-derived cells and includes: incubating living cells included in a sample taken from a person together with a fluorescently-labeled L-glucose derivative and detecting the fluorescently-labeled L-glucose derivative that is taken up into the cells; and detecting fluorescence emitted by the L-glucose derivative that is present within the cells while the cells are attached to a thin glass or plastic plate. Also provided is a dual detection method for cancer cells in which the cancer cell detection method that uses living body-derived cells is combined with a dyeing method using cells that are fixed using an alcohol or the like.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: February 4, 2020
    Inventors: Katsuya Yamada, Ayako Sasaki, Kouki Ono, Kiyoshi Tone
  • Patent number: 10407644
    Abstract: A perfume composition having controlled release of phytoncides in an atmosphere in order to generate an air condition resembling the air environment of a forest is provided. The perfume composition includes a) at least about 0.6% by weight of at least one phytoncide; and b) a perfume mixture including (i) at least one solvent; and (ii) at least one fragrance ingredient. At least about 25% by weight of the at least one phytoncide is selected from the group consisting of pinene alpha, pinene beta and combinations thereof.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: September 10, 2019
    Assignee: Givaudan S.A.
    Inventors: Philippe Blondeau, Alice Bresson Boil
  • Patent number: 9975853
    Abstract: The present invention relates to tetrahydroisoquinolinone derivatives, a pharmaceutical composition comprising the same and the use of these derivatives in the inhibition of the Hsp70 protein. The compounds are useful in the treatment or inhibition of cancer, autoimmune disease, rheumatoid arthritis, inflammatory bowel disease and psoriasis.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: May 22, 2018
    Inventors: Manik Chatterjee, Andreas Hartung, Ulrike Holzgrabe, Elisabeth Mueller, Ulrich Peinz, Christoph Sotriffer, David Zilian
  • Patent number: 9914961
    Abstract: The disclosure provides three-dimensional crosslinked polymer networks comprising one or more channels extending from the surface and/or near the surface of the network into the interior of the network, arrays comprising the networks, processes for making the networks, and uses of the networks and arrays.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: March 13, 2018
    Assignee: Safeguard Biosystems Holdings Ltd.
    Inventors: Holger Klapproth, Sonja Bednar
  • Patent number: 9890882
    Abstract: A fluidic device includes a planar structure constituted by a plurality of laminated layers and accommodating a fluid channel extending up to a surface of the planar structure, and a female adapter piece configured for a fluid-tight accommodation of a male adapter piece having a fluid conduit. The the female adapter piece is connected or connectable with the planar structure so that, when the male adapter piece is accommodated in the female adapter piece, the fluid conduit is brought in fluid-tight fluid communication with the fluid channel. The fluid channel is exposed to the female adapter piece at a lateral surface of the planar structure at which the laminated layers are exposed.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: February 13, 2018
    Assignee: Agilent Technologies, Inc.
    Inventors: Darijo Zeko, Manfred Berndt
  • Patent number: 9738926
    Abstract: The disclosure provides three-dimensional crosslinked polymer networks comprising one or more channels extending from the surface and/or near the surface of the network into the interior of the network, arrays comprising the networks, processes for making the networks, and uses of the networks and arrays.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: August 22, 2017
    Assignee: Safeguard Biosystems Holdings Ltd.
    Inventors: Holger Klapproth, Sonja Bednar
  • Patent number: 9598351
    Abstract: Several aromatic hydrocarbons di-substituted with a polyamine are described according to formulas selected from compounds 4, 7, 10, 15 and pharmaceutically acceptable salts thereof. The novel dimeric polyamines of the present invention demonstrate enhanced penetration into cells having an upregulated polyamine transport system, such as various types of cancer cells. The disclosed aromatic polyamine dimers provide highly efficient drugs for targeting cancer cells with active polyamine transporters.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: March 21, 2017
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Otto Phanstiel, IV
  • Patent number: 9482616
    Abstract: Disclosed herein are methods, kits and systems for signal amplification that can be used for many analytes. For example, a method of detecting an analyte in a sample includes contacting the sample containing the analyte with a detecting agent, wherein the detecting agent contains a specific binding agent that binds the analyte and zinc nanoparticles wherein the zinc nanoparticles and specific binding agent are coupled together; exposing the analyte bound to the specific binding agent which is coupled to the zinc nanoparticles to an acidic condition to release zinc ions from the zinc nanoparticles; contacting the released zinc ions with an indicator to generate a signal; and detecting the signal. The disclosed bioassay can be used in clinical and non-clinical settings. For example, the method can be used for clinical diagnosis, prognosis, and/or treatment-effectiveness or for testing for the presence of a substance like biological or chemical agents.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: November 1, 2016
    Assignee: Board of Regents of the Nevada System of Higher Education, on behalf the University of Nevada, Reno
    Inventor: Xiaoshan Zhu
  • Patent number: 9404887
    Abstract: The described embodiments may provide a method of fabricating a chemical detection device. The method may comprise forming a microwell above a CMOS device. The microwell may comprise a bottom surface and sidewalls. The method may further comprise applying a first chemical to be selectively attached to the bottom surface of the microwell, forming a metal oxide layer on the sidewalls of the microwell, and applying a second chemical to be selectively attached to the sidewalls of the microwell. The second chemical may lack an affinity to the first chemical.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: August 2, 2016
    Assignee: Life Technologies Corporation
    Inventors: Wolfgang Hinz, John M. Mauro, Shifeng Li, James Bustillo
  • Patent number: 9346756
    Abstract: The present invention demonstrates a newly designed and synthesized carbazole scaffold based electro-fluorescent emitter, 9-butyl-2,7-(2-(4-methoxyphenyl)ethynyl)-9H-carbazole (Cz(APhOMe)2), for ultra-violet OLED. This novel emitter has showed a high quantum yield of ˜78%. By doping in a host light-emitting layer of an OLED, the Cz(APhOMe)2 guest light-emitting material shows a UV light belong to the near-UV region with high external quantum efficiency. Most importantly, a variety of experiment results have proved that this UV light is a pure UV light having only one peak wavelength in the emission spectrum thereof. Ascertainably, this pure UV light can be applied in numerous applications, such as biological sensors chemical sensors, leakage detection in automobiles, crack detection in airplanes, high density information storage devices, water treatment for germicidal protection, forensic investigations, sanitation and sterilization, laboratory researches, food industries, and fraud detection.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: May 24, 2016
    Assignee: National Tsing Hua University
    Inventors: Jwo-Huei Jou, Sudhir Kumar, Justin Thomas Koil Pitchai Rajapandian
  • Patent number: 9285320
    Abstract: Cyano-substituted anthracene containing polyamines were synthesized and shown to be efficient polyamine transporter ligands. Moreover, these compounds (3 and 4) had improved fluorescence properties over previously known anthryl-polyamine conjugates, which facilitated their intracellular trafficking by confocal microscopy and fluorescence methods. These cytotoxic fluorescent agents may find use as molecular probes which traffic into cells via the polyamine transport system and may also be viable anticancer drugs which are readily quantified in human tissues due to their excellent fluorescence properties: (excitation: ? 405 nm) and emission (420 nm) occurs in the visible light range. The ability to excite and emit in the visible range provides an advantage to these probes as these wavelengths are considered non-toxic to human cells (versus ultraviolet mediated excitations, ?<400 nm) and visible light lasers are less costly to purchase and operate than UV laser sources.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 15, 2016
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Otto Phanstiel, IV
  • Patent number: 9211521
    Abstract: The invention provides a method for coating fluidic channels, particularly millifluidic channels, with a catalyst coating having controlled dimensions and morphology, and methods for preparing such channels, and devices that can be used in combination with the channels. The invention further provides portable, hand-held millifluidic devices applicable for a wide variety of uses including molecular reduction reactions, in situ material characterization, in situ reaction catalysis characterization, in situ reaction mechanism characterization, nanomaterial synthesis, nanostructured metal and metal oxide growth and coating of channels, continuous flow cell culturing, enzymatic catalysis, biomolecular catalysis, combinatorial chemistry, reactions involving homogeneous catalysts bound to channel walls, peptide synthesis, nucleic acid synthesis, synthesis of pharmaceutical intermediates, biofunctionalization of nanomaterials or a combination thereof.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: December 15, 2015
    Inventor: Siva Sai Ramana Kumar Challa
  • Patent number: 9175036
    Abstract: The present invention discloses antimicrobial water treatment membranes, comprising a water treatment membrane, covalently attached to one or more antimicrobial peptides or derivatives thereof, either directly or via one or more tether molecules. There are also provided a process for preparing these antimicrobial membranes, and uses thereof in water treatment applications.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: November 3, 2015
    Inventors: Roni Kasher, Ze'ev Ronen, Ehud Banin
  • Publication number: 20150140123
    Abstract: The invention relates to a method for screening compounds with (pro-)genotoxic activity by providing a system being capable of expressing a panel of defined proteins, incubating at least a portion of the system with compounds to be screened, and comparing the expression of the proteins in the system with the protein expression in a control system, thereby detecting the (pro-)genotoxic activity. Another object of the invention concerns a method for monitoring the likelihood of developing a physiological and/or pathological condition, which is caused, mediated and/or propagated by the genetic deregulation of proliferation, differentiation and/or damage repair, in response to a compound administered to a mammal in need of such treatment by determining an expression level of defined proteins in a biological sample withdrawn from the mammal. The invention also relates to a kit for screening compounds with (pro-)genotoxic activity comprising antibodies that specifically bind to marker proteins.
    Type: Application
    Filed: May 28, 2013
    Publication date: May 21, 2015
    Inventors: Stefan Otto Mueller, Yasmin Dietz
  • Publication number: 20150133331
    Abstract: Methods for the detection and screening of hepatocellular carcinoma (HCC) patients and for the monitoring of HCC treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. In other aspects, methods for detection and screening for the progression of high-risk conditions, such as HCV infections, to HCC and to monitoring treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. The biomarkers are sensitive and specific for the detection of HCC, and can also be used to classify HCV infections that are regarded as precursors of HCC.
    Type: Application
    Filed: May 21, 2013
    Publication date: May 14, 2015
    Applicant: Purdue Research Foundation
    Inventors: Michael Daniel Raftery, Jeremiah Bowers, Siwei Wei, Hamid Reza Baniasadi
  • Publication number: 20150126406
    Abstract: Disclosed herein are isobaric labeling reagent sets useful for multiplexed quantitation of peptides. The isobaric labeling reagent sets include a collection of at least two isobaric labeling reagents having first and second reporter groups with the same nominal mass but different isotopic substitutions and consequently different exact masses. Mass spectrometric analysis of the labeled samples is performed using a mass analyzer, such as an Orbitrap mass analyzer, capable of adequately resolving the ions of the first and second reporter groups. Reagent sets of the foregoing description may provide a degree of multiplexing in reporter ion quantitation experiments that is expanded relative to conventional labeling reagent sets, thereby reducing the number of chromatographic runs required for analysis and improving sample throughput.
    Type: Application
    Filed: December 18, 2014
    Publication date: May 7, 2015
    Inventors: Robert A. GROTHE, JR., Justin BLETHROW
  • Publication number: 20150126381
    Abstract: The invention combines the advantages of split and mix synthesis with the advantages of template directed synthesis. The method comprises the steps of: a) adding a linker molecule L to one or more reaction wells; b) adding a molecule fragment to each of said reaction wells; c) adding an oligonucleotide identifier to each of said reaction wells; d) subjecting said wells to conditions sufficient to allow said molecule fragments and said oligonucleotide identifiers to become attached to said linker molecule, or conditions sufficient for said molecule fragments to bind to other molecule fragments and sufficient for said oligonucleotide identifiers to bind to other oligonucleotide identifiers; e) combining the contents of said one or more reaction wells; and f) contacting the resulting bifunctional molecule(s) of step e) with one or more (oligonucleotide) templates each capable of hybridizing to at least one of the oligonucleotide identifiers added in step c).
    Type: Application
    Filed: January 6, 2015
    Publication date: May 7, 2015
    Inventor: Peter Birk Rasmussen
  • Publication number: 20150111778
    Abstract: This disclosure describes portable bio-nano-chip (BNC) assays of antiepileptic drugs (AED) using salivary samples. The BNC technology results in a more convenient, less expensive, and less time consuming sampling and analysis.
    Type: Application
    Filed: October 1, 2014
    Publication date: April 23, 2015
    Inventors: John T. MCDEVITT, Nicolaos CHRISTODOULIDES, Giridhar P. KALAMANGALAM
  • Publication number: 20150099668
    Abstract: This document provides methods and materials for assessing metabolites in a sample from a mammal (e.g., human) for determining the nature and extent of colorectal cancer (CRC) metastasis. For example, the document relates to the diagnosis, staging and prognosis of CRC in a mammal.
    Type: Application
    Filed: May 14, 2013
    Publication date: April 9, 2015
    Inventors: Farshad Farshidfar, Aalim M. Weljie, Karen Kopciuk, Hans J. Vogel, Oliver F. Bathe
  • Publication number: 20150094234
    Abstract: This invention relates to a method for characterizing and/or determining a samples, particularly in the aid of lanthanide(III) ions and ligands including an aromatic structure and 2-5 chelating heteroatoms. The invention relates also to an array for characterizing and/or determining a samples utilizing the properties of lanthanide(III) chelates.
    Type: Application
    Filed: April 23, 2013
    Publication date: April 2, 2015
    Inventors: Harri Härmä, Sari Pihlasalo
  • Publication number: 20150094233
    Abstract: The present invention provides a compound represented by the formula (I): or a salt thereof; and a method of quantitatively analyzing an amino group-containing target substance, including labeling a target substance in samples by using, as a labeling compound, two or more of such compounds having a mutually different mass due to isotope labeling, to confer a mass difference to the target substance between two or more samples, and the like.
    Type: Application
    Filed: March 28, 2013
    Publication date: April 2, 2015
    Inventors: Shigeru Matsukawa, Kazumi Narita, Yasushi Arakawa, Haruki Shimodaira
  • Publication number: 20150080265
    Abstract: Compositions which are fragrant and contain at least a member set culled from a library of compositions, each being comprised of sub-combinations of selected terpenes. Fragrances that mimic that of various states of organic and synthetic aromatics including products, processes and those from non-combusted plant products, among other things, uniquitous products, processes, medicinals, and related moieties leverage databases of all known terpene groupings are offered for consideration, and have been provided, according to the instant teachings.
    Type: Application
    Filed: August 25, 2014
    Publication date: March 19, 2015
    Inventors: Sytze Elzinga, Jeffrey C. Raber
  • Patent number: 8980637
    Abstract: A method for the parallel identification of one or more metabolite species within a biological sample is provided. The method comprises producing a first spectrum by subjecting the sample to a nuclear magnetic resonance analysis, the first spectrum containing individual spectral peaks representative of the one or more metabolite species contained within the sample; producing a second spectrum by subjecting the sample to a mass spectrometry analysis, the spectrum containing individual spectral peaks representative of the one or more metabolite species contained within the sample; subjecting each of the individual spectral peaks to a statistical pattern recognition analysis to identify the one or more metabolite species contained within the sample; and identifying the one or more metabolite species contained within the sample by analyzing the individual spectral peaks of the mass and nuclear magnetic resonance spectra.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: March 17, 2015
    Assignee: Purdue Research Foundation
    Inventors: Daniel M. Raftery, Zhengzheng Pan, Haiwei Gu
  • Publication number: 20150072894
    Abstract: The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.
    Type: Application
    Filed: September 17, 2014
    Publication date: March 12, 2015
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Stephen YUE, Gene SHEN, Wei-Chuan (David) SUN
  • Publication number: 20150065392
    Abstract: A reactive mass label for labelling a biological molecule for detection by mass spectrometry includes the following structure: X-L-M-S-Re, wherein X is a mass marker moiety, L is a cleavable linker, M is a mass normalization moiety, and S is a mass series modifying group including the following group: wherein J is C?O, K is NH, and n is 2 or J and K are both CH2 and n is 1, m is at least 1; and Re is a reactive functionality for attaching the reactive mass label to a biological molecule.
    Type: Application
    Filed: September 15, 2014
    Publication date: March 5, 2015
    Applicant: Electrophoretics Limited
    Inventors: Christian Baumann, Stefan Kienle, Karsten Kuhn, Harald Legner
  • Publication number: 20150065365
    Abstract: An apparatus is provided for sensing an analyte in a fluid.
    Type: Application
    Filed: May 12, 2014
    Publication date: March 5, 2015
    Applicant: Invoy Technologies, L.L.C
    Inventor: Lubna Ahmad
  • Publication number: 20150065389
    Abstract: The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen plasma. In certain embodiments, oxygen plasma is able to ablate selectively physisorbed layers of biomolecules (e.g., type-I collagen, fibronectin, laminin, and Matrigel) along complex non-linear paths which are difficult or impossible to pattern using alternative methods. In addition, certain embodiments of the present invention relate to the micropatterning of multiple cell types on curved surfaces, multiwell plates, and flat bottom flasks. The invention also features kits for use with the subject methods.
    Type: Application
    Filed: March 26, 2014
    Publication date: March 5, 2015
    Applicant: Massachusetts Institute of Technology
    Inventors: David T. Eddington, Sangeeta N. BHATIA
  • Publication number: 20150057185
    Abstract: Carbon monoxide (CO) is a member of the gasotransmitter family that includes NO and H2S and is implicated in a variety of pathological and physiological conditions. Whereas exogenous therapeutic additions of CO to tissues and whole animals have been well studied, the real-time spatial and temporal tracking of CO at the cellular level remains an open challenge. We now report a new type of turn-on fluorescent probe for selective CO detection by exploiting palladium-mediated carbonylation reactivity. The compounds of the invention are capable of detecting CO both in aqueous buffer and in live cells with high selectivity over a range of biologically relevant reactive small molecules, providing a potentially powerful approach for interrogating its chemistry in biological systems.
    Type: Application
    Filed: August 26, 2013
    Publication date: February 26, 2015
    Inventors: Christopher J. CHANG, Brian William Michel
  • Publication number: 20150038355
    Abstract: Provided are methods and compositions for immunoassay with improved specificity. The presently disclosed bead-based blocking agents reduce the interference associated with the samples and reagents of such assays.
    Type: Application
    Filed: July 25, 2014
    Publication date: February 5, 2015
    Inventors: Woei Tan, Deepa Jethwaney, Vinita Gupta, Qian-Shu Wang, Doris Yeung
  • Publication number: 20150024969
    Abstract: A method for determining prognosis, diagnosis and theronosis of a sepsis infection in a patient is disclosed. The method involves measuring the age, mean arterial pressure, hematocrit, patient temperature, and the concentration of one or more metabolites that are predictive of sepsis severity. The method can involve obtaining a blood sample from said patient and determining the concentration of the metabolite in the patient's blood; and then determining the severity of sepsis infection by analyzing the measured values in a weighted logistic regression equation.
    Type: Application
    Filed: September 12, 2012
    Publication date: January 22, 2015
    Inventors: Raymond Langley, Stephen Kingsmore
  • Publication number: 20150018240
    Abstract: Theranostics platforms for identifying drugs and nutraceuticals for treatment of rare disease are described. The platforms comprise (a) a cell-phenotype image-enhancing instrument; (b) a drug/nutraceutical library; and (c) a computer-implemented system for analyzing a response of an optically-visible rare-disease cell phenotype to a drug or nutraceutical from the drug/nutraceutical library.
    Type: Application
    Filed: February 15, 2013
    Publication date: January 15, 2015
    Inventors: Michael Jackson, Anne Bang
  • Publication number: 20150018245
    Abstract: Systems and methods for arranging microdevices on an array substrate are described. Each microdevice contains a lipid bilayer region and a patterned magnetic material that has a predetermined preferential axis of magnetization. The microdevices are located at specific locations on the arraying substrates and a magnetic field is used to orient the microdevices to facilitate the study of lipids and lipid-associated moieties. The bilayer region can also contain a fluorescent reagent, which can be monitored during exposure to an excitation source. The fluorescent reagent can also be photobleached and monitored for fluorescence recovery.
    Type: Application
    Filed: March 21, 2013
    Publication date: January 15, 2015
    Applicant: ARRAYOMICS, INC.
    Inventors: Edward T. Castellana, Bao Nguyen, David Rothwarf
  • Publication number: 20150011427
    Abstract: Patterned material depositions are formed on a surface of a substrate following filling each of one or more dispersions between each of spaces bounded by a stencil or a pair of patterned barriers on the surface of the substrate. Each dispersion comprises at least one liquid continuous medium and at least one dispersed material. Each patterned material deposition encompasses at least one dispersed material and is formed by evaporating the liquid continuous medium from the dispersion. Patterned material depositions may have multilayer structures. Systems include methods and device.
    Type: Application
    Filed: July 2, 2014
    Publication date: January 8, 2015
  • Publication number: 20140371105
    Abstract: The invention relates to a sensor assembly to detect and quantify organic and/or inorganic mercury compounds, including elemental mercury that may be present in gases or liquids, such as natural gas, air, condensates, crude oil, refined petroleum gas or liquids, and water including connate water, condensed water and water containing hydrate inhibitor(s). The sensor assembly includes a housing having a flow channel defined by an inlet, a sensor array, and an outlet. The sensor array is based on the differential sorption properties measured using a surface acoustic wave (SAW) sensor array, a chemiresistor array, or a combination of the two.
    Type: Application
    Filed: June 12, 2014
    Publication date: December 18, 2014
    Applicant: Chevron U.S.A. Inc.
    Inventors: David Glynn Thomas, Nicholas Paul Langley, Nicholas Charles Last, Roderick J. Travis
  • Publication number: 20140364325
    Abstract: A sensor array includes resonator sensors having respective receptor materials disposed thereon. The receptor materials have a physical property relevant to their ability to bind or adsorb one or more analytes in a sample. The physical property of the receptor materials on the sensors systematically increases or decreases in degree from one sensor to the next in the array. The device also comprises at least one detector for detecting sensor responses when masses of the analytes are adsorbed or bound to the receptor materials on the sensors. With this graded panel of sensors in the array, the analytes may adsorb or bind to the functionalized sensors with a pattern of responses specific to each analyte.
    Type: Application
    Filed: June 5, 2013
    Publication date: December 11, 2014
    Inventors: Michael D Cable, Heinrich Sussner
  • Publication number: 20140364339
    Abstract: The ?,?-unsaturated ?-amino acids of general formula (I). Also, a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. Further, intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I). Compounds of general formula (I) may be useful as therapeutic substances, or as reagents or intermediates for fine chemistry.
    Type: Application
    Filed: August 28, 2012
    Publication date: December 11, 2014
    Inventors: Sylvain Jugé, Jérôme Bayardon, Emmanuelle Remond, Marie-Joëlle Ondel-Eymin
  • Publication number: 20140357503
    Abstract: Disclosed embodiments concern an array for use in identifying or identifying and quantifying analytes in a sample using a macrocyclic sensor comprising a macrocyclic compound and a detectable moiety. The disclosed array may be used to discriminate among various analytes based on different features, such as post-translational modifications, isomeric post-translational modifications, and the peptide sequence around post-translational modifications. Also disclosed is a method for identifying analytes comprising a post-translational modification, as well as an enzymatic assay using the disclosed macrocyclic sensor.
    Type: Application
    Filed: June 11, 2014
    Publication date: December 4, 2014
    Applicant: UVic Industry Partnerships Inc.
    Inventors: Fraser Hof, Samuel Minaker, Kevin Daze, Sara Tabet, Manuel Ma
  • Publication number: 20140357504
    Abstract: A system and methods for consumer use of a microarray product are provided. A method includes obtaining a microarray product and contacting the microarray product with a sample and performing bioassays. The method further includes obtaining a decoding information data package from a manufacturer of the microarray product for correlating bioassay signals from the bioassays with respective analytes, wherein the microarray product is obtained at a first time different and discrete from a second time that the decoding information data package is obtained.
    Type: Application
    Filed: June 2, 2013
    Publication date: December 4, 2014
    Inventors: Dieter Trau, Andreas Schmidt
  • Publication number: 20140349885
    Abstract: A method, a labeling reagent, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological matrices. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry.
    Type: Application
    Filed: December 6, 2012
    Publication date: November 27, 2014
    Inventors: Subhakar Dey, Subhasish Purkayastha
  • Publication number: 20140323353
    Abstract: Embodiments of the present disclosure provide for arrays, systems, and methods analyzing cells, methods of making arrays, and the like.
    Type: Application
    Filed: May 22, 2014
    Publication date: October 30, 2014
    Inventors: Benjamin George Keselowsky, Abhinav Prakash Acharya, Emina Huang, Edward William Scott, Matthew Carstens
  • Publication number: 20140323322
    Abstract: A chemical sensor comprising: a hydrogel layer, comprising one or more molecular recognition agents and a 2DPC self-assembling array; and a mirror layer. A method for analyzing a sample or bodily fluid, comprising: obtaining a sample or bodily fluid; placing an amount of the sample or bodily fluid onto a chemical sensor, comprising: a hydrogel layer, comprising a molecular recognition agent and a 2DPC self-assembling array; a tethering hydrogel layer; a mirror layer; and a membrane filter layer, allowing the bodily fluid to interact with the hydrogel layer; and allowing ambient or artificial light to pass through the hydrogel layer onto the mirror layer and observing a change in diffraction versus a control.
    Type: Application
    Filed: October 4, 2012
    Publication date: October 30, 2014
    Inventor: Sanford A. Asher