Abstract: A method of treating acute myeloid leukemia (AML), including the steps of (i) measuring a density of blast cells in the peripheral blood and the bone marrow of a subject with AML; (ii) administering to the subject a CXCR4 antagonist; and (iii) administering to the subject a therapeutically effective amount of the CXCR4 antagonist and a therapeutically effective amount of a chemotherapeutic agent, if the blast cell density in the peripheral blood is less than 10% of the total peripheral white blood cells, or at least five-fold lower than the blast cell density in the bone marrow, or at least two-fold higher one day or more following step (ii).

Abstract: Methods of preparing unsaturated compounds or analogs through dehydrogenation of corresponding saturated compounds and/or hydrogenation of aromatic compounds are disclosed.

Abstract: The present invention concerns 2-methyl-5-[2-methyl-3-methylene-bicyclo[2.2.1]hept-5-en-2-yl)]-2-penten-1-ol in any of its stereometric forms or a lower ester thereof and their use as perfuming ingredient, in particular to impart sandalwood and cedar wood notes.

Abstract: 1-(3/4-isobutyl-1/6-methylcyclohex-3-enyl)methanols and derivatives thereof having appreciable floral and hesperidic odor notes, their use as fragrance ingredient and perfumed products comprising them.

Abstract: Compositions which are fragrant and contain at least a member set culled from a library of compositions, each being comprised of sub-combinations of selected terpenes. Fragrances that mimic that of various states of organic and synthetic aromatics including products, processes and those from non-combusted plant products, among other things, uniquitous products, processes, medicinals, and related moieties leverage databases of all known terpene groupings are offered for consideration, and have been provided, according to the instant teachings.

Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

Abstract: 1-(3/4-isobutyl-1/6-methylcyclohex-3-enyl)methanols and derivatives thereof having appreciable floral and hesperidic odor notes, their use as fragrance ingredient and perfumed products comprising them.

Abstract: Sandalwood perfuming ingredients that are 2-[perhydro-trialkyl-2-naphthalenylidene]-1-propanol or propanal derivatives of the formula wherein one dotted line represents a carbon-carbon single bond and the other a carbon-carbon single bond or double bond; X represents a CH2OH group or a CHO group; each R1 represents a hydrogen atom or a methyl group; and the R2, taken separately, represent each a hydrogen atom or the two R2 groups, taken together, represent a CH2 group or a carbon-carbon double bond; and said compound is in the form of any one of its stereoisomers or a mixture thereof, along with the use of such compound(s) in perfuming compositions or articles in the perfumery industry.

Abstract: The present invention relates to perfumed composition which comprises: a) from 1% to 25% by weight of a fragrance composition; b) from 1% to 10% by weight of at least one nonionic surfactant having at least two hydrophobic chains each containing from 4 to 20 carbon atoms; c) from 1% to 10% by weight of at least one anionic surfactant having at least two hydrophobic chains each containing from 4 to 20 carbon atoms; d) from 1% to 20% by weight of solvent which is a diol having from 4 to 12 carbon atoms, preferably from 4 to 8 carbon atoms, or a mixture of such diols; e) at least 50% by weight of water.

Abstract: The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.

Abstract: The present invention is directed to novel fragrance compounds and their unexpected advantageous use in enhancing, improving or modifying a fragrance formulation through the addition of an olfactory acceptable amount of the compounds, wherein the compounds are represented by the following formula: wherein a methyl group is bonded to the 5-membered ring at position 2 or 3, or a mixture thereof.

Abstract: The present invention is directed to novel fragrance compounds and their unexpected advantageous use in improving, enhancing or modifying a fragrance formulation through the addition of an olfactory acceptable amount of the compounds, wherein the compounds are represented by the following formula: wherein R1, R2, R3, R4, and R5 are independently selected from the group consisting of hydrogen and C1-C5 alkyl.

Abstract: The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.

Abstract: The present invention pertains to a method of counteracting a malodor by introducing a malodor counteracting effective amount of a novel 3.2.

Abstract: The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.1-bicyclo-octene and -octane compounds of the present invention are represented by formula: wherein R is selected from the group consisting of hydrogen, acetate, carbonate monomethyl ester, and allyloxy; and wherein the broken line represents a single or double bond.

Abstract: The present invention relates to the field of perfumery. More particularly, it concerns co-polymers, derived from a maleic anhydride derivative and a ethylenic derivative, comprising at least one ?-oxy or ?-thio carbonyl moiety capable of liberating an active molecule such as, for example, an ?,?-unsaturated ketone, aldehyde or carboxylic ester. The present invention concerns also the use of polymers or co-polymers in perfumery as well as the perfuming compositions or perfumed articles comprising the invention's compounds.

Abstract: Sandalwood perfuming ingredients that are 2-[perhydro-trialkyl-2-naphthalenylidene]-1-propanol or propanal derivatives of the formula wherein one dotted line represents a carbon-carbon single bond and the other a carbon-carbon single bond or double bond; X represents a CH2OH group or a CHO group; each R1 represents a hydrogen atom or a methyl group; and the R2, taken separately, represent each a hydrogen atom or the two R2 groups, taken together, represent a CH2 group or a carbon-carbon double bond; and said compound is in the form of any one of its stereoisomers or a mixture thereof, along with the use of such compound(s) in perfuming compositions or articles in the perfumery industry.

Abstract: The present invention relates to perfumed composition which comprises: a) from 1% to 25% by weight of a fragrance composition; b) from 1% to 10% by weight of at least one nonionic surfactant having at least two hydrophobic chains each containing from 4 to 20 carbon atoms; c) from 1% to 10% by weight of at least one anionic surfactant having at least two hydrophobic chains each containing from 4 to 20 carbon atoms; d) from 1% to 20% by weight of solvent which is a diol having from 4 to 12 carbon atoms, preferably from 4 to 8 carbon atoms, or a mixture of such diols; e) at least 50% by weight of water.

Abstract: Deodorant compositions are disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of malodor. Deodorant compositions are also disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of gender-specific malodor. The methods feature reducing perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to reduce perception of such odor. Other methods feature blocking perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to occupy an odorant receptor site, thereby blocking interaction of the site with other odorants.

Abstract: A process for the hydrogenation of a mixture of caryophyllenes by contact with hydrogen in the presence of a supported catalyst. The resulting products are useful for the application to skin.

Abstract: Novel compounds of formula I and their use in flavour and fragrance compositions. R1 to R13 have the meaning as described in the specification.

Abstract: The present invention is directed to novel compounds of the general formula wherein R is hydrogen, a straight, branched or cyclic hydrocarbon moiety consisting of less than 10, most preferably less than 4 carbon atoms and containing single and/or double bonds, an acetyl group and substituted acetyl groups including cyclic groups, such as cyclopropyl acyl group, alkoxy ether groups and alkyl substituted alkoxy ether moieties such as, but not limited to, CH2—O—CH2—R5 wherein R5 is a C1-C4 alkyl group as well as double bond containing alkyl groups; R1 is selected from the group consisting of hydrogen or a C1-C4 alkyl group and R2 and R3 is independently equal to methyl; and wherein one of the dashed lines between the 5 and 10 position, the 4 and 5 position and the 5 and 6 position represents a second C—C bond in a C?C double bond.

Abstract: A fragrance composition is provided comprising from about 10% wt to about 40% wt of a residual accord, the residual accord comprising perfume raw materials (PRMs) selected from at least three of the five defined classes. In addition, personal care compositions comprising the defined fragrance composition are also provided.

Abstract: Perfume compositions effective against urine malodour and having a low odour, comprise between 20% and 50% of perfume ingredients comprising at least 15% by-weight of N-ethyl-N-(3-methylphenyl) propanamide.

Abstract: Perfume compositions comprise between 10% and 30% in total by weight of perfume ingredients selected from two groups, Group A, Group B, with the provisos that over 5% but less than 15% of the perfume composition must comprise Group A ingredients, and for compositions comprising less than 10% of Group A ingredients the agregate percentage of Group B ingredients present must be at least equal to the expression 2*/10-A%) where A% is the total percentage of Group A ingredients in the composition.

Abstract: The use as fragrance ingredient of a compound of formula (I) wherein R1 and Y have the same meaning as given in the description, and fragrance applications comprising them.

Abstract: The present invention relates to substituted bicyclo[3.3.1]nonanes and bicyclo[3.3.1]nonenes of formula (I) wherein R, and R1 to R5 have the same meaning as described in the specification.

Abstract: The present invention relates to substituted bicyclo[3.3.1]nonanes and bicyclo[3.3.1]nonenes of formula (I) wherein R, and R1 to R5 have the same meaning as described in the specification.

Abstract: The compounds 6-oxabicylco[3.2.1]octane, 5-methyl-1-(1,2,2-trimethylbicyclo [3.1.0]hex-3-yl)- and 2-oxabicyclo[2,2,2]octane, 1-methyl-4-(1,2,2-trimethylbicyclo [3,1,0]hex-3yl)-, and their uses in fragrance applications.

Abstract: The use as fragrance ingredient of a compound of formula (I) wherein R1 and Y have the same meaning as given in the description, and fragrance applications comprising them.

Abstract: The compound 2-oxabicyclo[2,2,2]octane, 1-methyl-4-(1,2,2-trimethylbicyclo[3,1,0]hex-3-yl)— and its uses in fragrance applications.

Abstract: The present invention provides preventive and/or therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt. Also, the present invention provides a novel peptide having a CXCR4 antagonism, its amide, its ester and its salt.

Abstract: Described is a solid phase benzopyran composition comprising predominately 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[G]-2-benzopyran and at least one other benzopyran compound. The novel compositions are used in augmenting, enhancing and/or imparting aromas in to consumable materials such as perfume compositions, perfumed articles including soaps, detergents, fabric softener compositions, fabric softener articles, fragranced candles, cosmetics, hair preparations, perfumed polymers and colognes. Also described is a process for producing the solid phase benzopyran compositions.

Abstract: The present invention is directed to novel compounds of the general formula wherein R is selected from the group consisting of hydrogen, a straight, branched or cyclic alkyl that may or may not be unsaturated, alkenyl groups, an acetyl group, a substituted acetyl groups, an alkoxy ether group or alkyl substituted alkoxy ether moieties with each R, other than hydrogen comprising from 1 to 10 carbon atoms; R1, R2 and R3 independently represent hydrogen, a C1-C4 alkyl group such as methyl and ethyl and in which one of the dashed lines is a double bond and the other dashed line is a single bond.

Abstract: Described are polyalkylbicylic chemical derivatives for use a fragrance ingredients having the generic structure: wherein m=0 or 1; wherein X is methyl or hydrogen; wherein R1, R2, R3 and R4 each represents methyl or ethyl with the proviso that when X is methyl, each of R1, R2, R3 and R4 is methyl and when X is hydrogen, one of R1, R2, R3 and R4 is ethyl; and wherein R6 represents hydrogen or methyl. Methods for using and making these compounds are also disclosed.

Abstract: The present invention relates to the perfumery industry. It concerns more particularly an alcohol, ester, ether or ketone derivative having a spiro-type skeleton, the latter being substituted by short alkyl groups. The invention also relates to the use of the invention compounds as perfuming ingredients, able to impart a woody and/or aromatic, as well as to the perfumed articles or perfuming compositions comprising as active ingredient a compound of formula (I).

Abstract: The present invention relates to a process for solubilizing keratins from a keratin containing starting material such as poultry feathers. The keratins are may be solubilized using a sulphide under alkaline conditions. In the process the cysteine residues of solubilized keratins and are partially modified, e.g. by alkylation. The conditions of solubilisation and partial modification are chosen such that the keratins are also partially hydrolyzed. The partially modified and partially hydrolyzed keratin may be used as stable dispersions e.g. for the production of films and coatings by casting.

Abstract: The compound according to the formula set forth below and the use of the compound in creating fragrances, and scents in items such as perfumes, colognes and personal care products is disclosed.

Abstract: The present invention relates to the use as perfuming ingredient of 1-oxaspiro[2.11]tetradecane, as well as to the perfuming compositions or perfumed articles containing said compound.

Abstract: The present invention relates to a method by which saccharide compounds can be prepared in a very easy way. This method comprises the steps of: (a) attaching at least one saccharide to a cyclic or acyclic diene, (b) reacting the saccharide-containing diene obtained in step (a) or a commercially available saccharide-containing diene with a dienophile by Diels-Alder reaction.

Abstract: The invention concerns a novel compounds of formula (I), wherein the dotted line bond is present or not, and wherein R1 represents: when the dotted line bond is present —CHCH3OH or —CHCH3OCOR or —CHCH3XCH2CHOHR? or —CHCH3OCHR?CH2OH or formula (II) when the dotted line bond is absent —CHCH3OH or —CHCH3OCOR or —COCH3 or formula (II) or —CHCH3XCH2CHOHR? or —CH2CH2XCH2CHOHR? or —CHCH3OCHR?CH2OH or —CHCHCOR? or —CH2CH2CHR?OH or —CH2CH2CHR?OCOR or CHCHCHOHR? or —CHCHCHR?OCOR, wherein R represents H, Me, Et, Pr, isoPr, But, isoBut, CH3CH2)4, (CH3)2CHCH2, CH2CH, (CH3)2CCH, and R? represents H, Me or Et, and X represents O, N or S, and their preparation method. Because of their fragrance, said compounds are highly interesting for the perfume industry, for cosmetic and care products.

Abstract: Plastic additives which are useful as nucleating agents and which are especially useful for improving the optical properties of polymeric materials are provided. More particularly, this invention relates to certain alkyl (or alkoxy) substituted fluoro-benzylidene sorbitol acetals and polymer compositions thereof which may be utilized within, as merely examples, food or cosmetic containers and packaging. These inventive fluorinated and alkylated benzylidene sorbitol acetals are also useful as gelling agents for water and organic solvents, particularly those used in the preparation of antiperspirant gel sticks.

Abstract: Plastic additives which are useful as nucleating agents and which are especially useful for improving the optical properties of polymeric materials are provided. More particularly, this invention relates to certain alkyl (or alkoxy) substituted fluoro-benzylidene sorbitol acetals and polymer compositions thereof which may be utilized within, as merely examples, food or cosmetic containers and packaging. These inventive fluorinated and alkylated benzylidene sorbitol acetals are also useful as gelling agents for water and organic solvents, particularly those used in the preparation of antiperspirant gel sticks.

Abstract: A composition comprising at least 60% by weight, based on the weight of the composition, of a cyclopentanone or cyclopentanol compound having 2,5-dicyclopentylidene substituents, 2,5-dicyclopentyl substituents or 2-cyclopentylidene-5-cyclopentyl substituents. This composition is useful as perfume emitting floral fragrance. 2,5-Dicyclopentylidenecyclopentane (compound 4) is prepared by reaction of 2-cyclopentylidenecyclopentanone with cyclopentanone. 2,5-Dicyclopentylcyclopentanone (compound 5) and 2,5-dicyclopentylidenecyclopentanol (compound 6) are prepared by reduction of compound 4. 2,5-Dicyclopentylcyclopentanol (compound 7) is prepared by reduction of compound 5 or compound 6.

Abstract: The invention relates to new chemical compounds useful as perfumes or as components of perfumes. More specifically it relates to alkyl-substituted 2-acylindenes and isomeric mixtures thereof, as well as to perfume compositions comprising said compounds. Furthermore, the invention relates to the use of said compounds and methods of making said compounds.

Abstract: The compound according to the formula set forth below where A is B is or A and B together form the ring structure and X, R′ and R are independently H and CH3 and m=0 or 1. and the use of the compound in creating fragrances, and scents in items such as perfumes, colognes and personal care products is disclosed.

Abstract: Described is the compound of the Formula

Abstract: The use of tricyclic aldehydes as odorous materials, which can be produced through partial or total hydroformylation of tricyclo[5.2.1.02,6]-dec(adi)enes, except saturated monoaldehydes, is described. The fragrance enhancing capacity of the compounds is described in methods for their use both as perfumes and perfume enhancers or boosters.

Abstract: The compound according to the formula set forth below 1

Abstract: The invention relates to new chemical compounds useful as perfumes or as components of perfumes. More specifically it relates to alkyl-substituted 2-acylindenes and isomeric mixtures thereof, as well as to perfume compositions comprising said compounds. Furthermore, the invention relates to the use of said compounds and methods of making said compounds.