With Carboxylic Acid, Ester Or Metal Salt Thereof Patents (Class 514/163)
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Patent number: 5891451Abstract: A method and composition is provided for treating skin conditions including those arising from dermatologic disorders, chronoaging and environmental abuse. Non-ring esterified C.sub.11 -C.sub.30 alkyl or alkenyl esters of salicylic acid are used as the active component in combination with a pharmaceutically acceptable carrier. Most preferred is tridecyl salicylate.Type: GrantFiled: May 7, 1997Date of Patent: April 6, 1999Assignee: Elizabeth Arden Company, Division of Conopco, Inc.Inventors: Angel Augusto Guerrero, Peter Ladislaus Dorogi, Thomas Charles Klepacky
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Patent number: 5827543Abstract: The subject invention encompasses methods for prevention and treatment of a human or lower animal subject having a urogenital disorder caused or mediated by one or more parasitic protozoa comprising administering to the subject bismuth and one or more antimicrobials. The subject invention also encompasses compositions comprising bismuth and one or more antimicrobials for the prevention and treatment of a human or lower animal subject having a urogenital disorder caused or mediated by one or more parasitic protozoa.Type: GrantFiled: December 7, 1995Date of Patent: October 27, 1998Assignee: The Procter & Gamble CompanyInventor: Jamesina Anne Fitzgerald
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Patent number: 5716648Abstract: Compositions for use in the regulation of subnormal pH values in intestinal tract and for treatment of bowel diseases. The compositions comprise a coating and a substantially insoluble alkaline material confined within said coating, the composition being adapted so as to ensure the availability of an amount of said pH regulating alkaline material in the lumen of the gastrointestinal tract exhibiting subnormal pH values. E.g. In the proximal small intestine, the mid small intestine, the distal small intestine, the caecum, the ascending colon, the transverse colon, the descending colon, the sigmoid colon and/or the rectum. The compositions may also comprise a medicament for treatment of bowel disease, e.g. 5-aminosalicylic acid for the treatment of Crohn's disease and colitis ulcerosa. The administration may be oral composition or enemas or suppositories.Type: GrantFiled: December 21, 1995Date of Patent: February 10, 1998Assignee: Farmaceutisk Laboratorium Ferring A/SInventors: S.o slashed.ren Halskov, Svenn Kluver Jepsen
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Patent number: 5674858Abstract: The use is described of both (i) ranitidine bismuth citrate and (ii) one or more Helicobacter pylori-inhibiting antibiotics in treating or preventing gastrointestinal disorders.Pharmaceutical compositions containing both (i) and (ii) and methods for the preparation of pharmaceutical compositions containing (i) and (ii) are also described.Type: GrantFiled: June 5, 1995Date of Patent: October 7, 1997Assignee: Glaxo Group LimitedInventor: Andrew Alexander McColm
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Patent number: 5411988Abstract: There is disclosed compositions and methods for inhibiting inflammation and/or adhesion formation in a patient. The compositions comprise omega-3 and/or omega-6 fatty acids, a nonionic surfactant, and a pharmaceutically acceptable carriers or diluents. The omega fatty acid compositions may optionally contain cyclooxygenase inhibitors and other additives and preservatives such as dextrose and vitamin A. The methods of inhibiting inflammation and/or adhesion formation in a patient comprise administration of an effective quantity of a composition to a body cavity of the patient.Type: GrantFiled: October 27, 1993Date of Patent: May 2, 1995Inventors: Barry I. Bockow, Marc D. Erlitz
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Patent number: 5296476Abstract: The present invention relates to a topical skin care formulation comprised of micronized calcium citrate and salicylic acid. This composition provides a method for treating acne as well as providing for a variety of skin beautification products which are especially applicable to sensitive skin.Type: GrantFiled: April 30, 1991Date of Patent: March 22, 1994Inventor: Esther G. Henderson
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Patent number: 5256684Abstract: Methods, for the treatment of humans and lower animal subjects having a gastrointestinal disorder, comprising administering bismuth and administering an antimicrobial. From about 50 to about 5000 milligrams of bismuth are administered, per day, for from 3 to 56 days. A safe and effective amount of antimicrobial is administered for from 1 to 21 days. Preferred processes also include a step for performing a diagnostic test on the subject for detection of a campylobacter-like organism infection of the subject. The invention also provides compositions containing a safe and effective amount of bismuth and a safe and effective amount of antimicrobial.Type: GrantFiled: July 26, 1991Date of Patent: October 26, 1993Assignee: The Procter & Gamble CompanyInventor: Barry J. Marshall
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Patent number: 5151415Abstract: A method for treating an epithelial tumor of a viral infection involves repeated applications of a paste of acetylsalicylic acid and water to the infection until it is arrested.Type: GrantFiled: May 23, 1991Date of Patent: September 29, 1992Inventor: Dallas Sirany
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Patent number: 5145686Abstract: Topical pharmaceutical compositions for the treatment of lesions of the skin or mucous membranes containing a physiologically acceptable lithium salt together with at least one substance selected from substances capable of selectively increasing the in vivo level of E-series prostaglandins, substances capable of inhibiting cyclooxygenase enzyme, substances capable of inhibiting the formation of lipoxygenase products, and lysine.Type: GrantFiled: January 8, 1992Date of Patent: September 8, 1992Assignee: Efamol LimitedInventors: David F. Horrobin, Julian Lieb
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Patent number: 5081158Abstract: Medicated protective films are formed in situ on body tissue by applying a composition comprising (a) hydroxypropyl cellulose; (b) an esterification agent which reacts with the hydroxypropyl cellulose to form a reaction product which is soluble in the solvent of (c), but insoluble in body fluids at body temperatures; and (c) a nontoxic volatile solvent for said hydroxypropyl cellulose and said reaction products; and (d) a separate medicinal component. The films are tough, resilient and adhesive to body tissue including the mucosa.Type: GrantFiled: March 8, 1990Date of Patent: January 14, 1992Assignee: Zila Pharmaceuticals, Inc.Inventor: Edwin Pomerantz
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Patent number: 5006516Abstract: The invention relates to an agent for the prophylaxis of cardiac infarcti and for the prevention or reinfarctions, and is characterized by the fact that said agent comprises a combination of magnesium amino dicarboxylic acid halides, basic magnesium amino dicarboxylic acid salts, and magnesium halides, singly or in combination, on the one hand, and acetylsalicylic acid, on the other hand, as well as conventional pharmaceutical carriers, diluents, and/or adjuvants, as required.Type: GrantFiled: May 1, 1989Date of Patent: April 9, 1991Assignee: Verla-Pharm Arzneimittelfabrik Apotheker H.J.V. Ehrlich GmbH & Co. KG.Inventors: Joachim Helbig, Hans G. Classen
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Patent number: 4988679Abstract: There is provided an orally ingestible liquid composition for suspending therein an orally administrable pharmaceutically active composition releasable over an extended period of time comprises triglyceride of a medium chain length alkanoic acid or distilled acetylated monoglycerides, a liquid, high HLB polyglyceryl ester, and colloidal silicon dioxide together with a material soluble or dispersible therein and capable of being insolubilized by a pharmaceutically acceptable polyvalent cation and a solid pharmaceutically acceptable salt containing the cation required therefore. Sustained release compositions based thereon containing pharmaceutically active agents are also disclosed.Type: GrantFiled: June 19, 1989Date of Patent: January 29, 1991Inventors: Leonard Chavkin, Leonard Mackles
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Patent number: 4942031Abstract: A composition comprising LYCD together with known topically active useful medicinal agents such as antiwrinkling, antibiotic, anticancer, antifungal, antiinflammatory, antiviral, steroid, and wound healing agents. The LYCD works together with the other active ingredients to achieve a synergistic result more effective than can be obtained from the topical agents individually, and more effective than could be predicted from the mere addition of the known efficacies of the individual ingredients.Type: GrantFiled: August 16, 1989Date of Patent: July 17, 1990Inventor: Robert H. Levin
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Patent number: 4933330Abstract: A pharmaceutical composition for use in the treatment of psoriasis comprises 4-aminosalicylic acid (4-ASA) or 5-aminosalicylic acid (5-ASA) or a functional derivative thereof, said pharmaceutical composition being in a form suitable for topical administration. Furthermore, 4- or 5-ASA or a functional derivative thereof are used for the manufacture of pharmaceutical compositions for treating psoriasis, atopic dermatitis, allergic dermatitis, contact dermatitis, seborrhoic dermatitis, or acne diseases. The derivatives have the formulae: ##STR1## where W is COOX, wherein X is H, Li, Na, K, Mg.sub.0.5, Ca.sub.0.5, Zn.sub.0.5, Al.sub.0.33, Fe(II).sub.0.5, Fe(III).sub.0.33, NH.sub.4, NH.sub.3 R.sup.1, NH.sub.2 R.sup.1.sub.2, NHR.sup.1.sub.3, NR.sup.1.sub.4, or R.sup.1, where R.sup.1 is substituted or unsubstituted C.sub.1-6 -alkyl, aryl-C.sub.1-4 -alkyl, or heteroaryl-C.sub.1-4 -alkyl; or COX, where X is NR.sup.1 R.sup.1', where R.sup.1' has the same meaning as R.sup.1 defined above and R.sup.1 and R.sup.Type: GrantFiled: March 30, 1988Date of Patent: June 12, 1990Assignee: DAK-LaboratorietInventors: Anne P. Jorgensen, Torkil Menne
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Patent number: 4911922Abstract: Disclosed is a pharmaceutical composition for use in desensitizing hypersensitive dentin or eliminating odontalgia comprising N-methacryloyl aminosalicylic acid as an active ingredient. The composition may further include an unsaturated compound and a polymerization initiator optionally for retaining the desensitizing effect.Type: GrantFiled: August 15, 1988Date of Patent: March 27, 1990Assignee: Eiichi MasuharaInventors: Eiichi Masuhara, Hiroyasu Hosoda
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Patent number: 4849418Abstract: Transdermally absorbable water-containing preparations of therapeutically active arylpropionic acid derivatives comprises 1 to 15% by weight of such active ingredient, from 10 to 40% by weight of polyoxyethylene polyoxypropylene copolymers, from 10 to 50% by weight of one or more physiologically acceptable organic solvents, optionally up to 1% by weight of preservatives, colorants and/or perfumes, and at least 10% by weight of water. From polyoxyethylene polyoxypropylene copolymers having a relative molecular weight of more than 6,000 there may also be prepared gels, if certain ratios of amounts are chosen.Type: GrantFiled: November 16, 1987Date of Patent: July 18, 1989Assignee: Dolorgiet Beteiligungs-GmbHInventors: Manfred Lohner, Hans H. Wagener
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Patent number: 4798811Abstract: A combination of verapamil, gallopamil or anipamil and acetylsalicylic acid in a weight ratio of from 10:1 to 2:1 being useful in the treatment of circulatory disorders.Type: GrantFiled: January 7, 1988Date of Patent: January 17, 1989Assignee: BASF AktiengesellschaftInventors: Hans D. Lehmann, Rolf Kretzschmar, Klaus-Juergen Hahn
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Patent number: 4752606Abstract: The invention provides oleanolic acid and/or a physiologically acceptable salt thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced and/or stress-induced.The invention also provides a pharmaceutical composition comprising an active amount of oleanolic acid and/or a physiologically acceptable salt thereof in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of oleanolic acid in preventing and/or significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.Type: GrantFiled: September 14, 1984Date of Patent: June 21, 1988Assignee: 501 Noristan LimitedInventors: Friedrich O. Snyckers, Theunis G. Fourie
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Patent number: 4731384Abstract: The invention relates to topical antiinflammatory medicament formulations which also have analgesic activity and contain 2-(2-hydroxyethoxy)-ethyl N-(.alpha.,.alpha.,.alpha.,-trifluoro-m-tolyl) anthranilate as the active ingredient and an adjuvant which is preferably a triglyceride.Type: GrantFiled: March 20, 1986Date of Patent: March 15, 1988Assignee: Troponwerke GmbH & Co, KGInventors: Hans-Dieter Dell, Reinhold Kraus, Detlef Schierstedt
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Patent number: 4699902Abstract: The invention relates to a process for the production of pharmaceutical preparations based on 5-aminosalicylic acid in which the 5-aminosalicylic acid is mixed with physiologically and toxicologically acceptable, basic auxiliaries and/or buffer mixtures, which in a 1% aqueous solution give pH-values in the range from 8 to 12, and the mixture obtained is processed in known manner to form tablets, film tablets, dragees, capsules or suppositories, or in which the 5-aminosalicylic acid is mixed with a concentrated aqueous solution of the above-mentioned basic auxiliaries and/or buffer mixtures, the 5-aminosalicylic acid salt formed is precipitated, separated off from the aqueous solution and dried and the salt obtained is processed in known manner to form tablets, film tablets, dragees, capsules or suppositories.Type: GrantFiled: October 7, 1986Date of Patent: October 13, 1987Inventor: Kurt H. Bauer
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Patent number: 4664915Abstract: A compressed and formed alkaline component suitable for use in a buffered aspirin product. The alkaline component is made of alkaline materials selected from the group consisting of calcium carbonate, magnesium carbonate, magnesium oxide, magnesium hydroxide and mixtures thereof and having incorporated therein citric acid and monobasic sodium phosphate.Type: GrantFiled: February 21, 1986Date of Patent: May 12, 1987Assignee: Bristol-Myers CompanyInventor: Hovsep Simonian
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Patent number: 4632921Abstract: The invention relates to a process for the production of pharmaceutical preparations based on 5-aminosalicylic acid in which the 5-aminosalicylic acid is mixed with physiologically and toxicologically acceptable, basic auxiliaries and/or buffer mixtures, which in a 1% aqueous solution give pH-values in the range from 8 to 12, and the mixture obtained is processed in known manner to form tablets, film tablets, dragees, capsules or suppositories, or in which the 5-aminosalicylic acid is mixed with a concentrated aqueous solution of the above-mentioned basic auxiliaries and/or buffer mixtures, the 5-aminosalicylic acid salt formed is precipitated, separated off from the aqueous solution and dried and the salt obtained is processed in known manner to form tablets, film tablets, dragees, capsules or suppositories.Type: GrantFiled: July 26, 1985Date of Patent: December 30, 1986Inventor: Kurt H. Bauer
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Patent number: 4614648Abstract: The invention relates to a process for manufacturing effervescent tablets consisting in the steps of careful humidifying of the acid+base mixture, pre-drying and final drying and granulating.It has been found that these operations can be performed in a single apparatus, either integrally in fluid bed, or with vacuum-drying.Type: GrantFiled: August 20, 1984Date of Patent: September 30, 1986Inventor: Jean Bru
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Patent number: 4608370Abstract: Skin treating composition comprising about 3 to about 7 parts salicylic acid, about 8 to 12 parts resorcinol, about 8 to about 12 parts lactic acid, and about 60 to about 90 parts ethyl alcohol, by weight. The composition is applied to the face, and after approximately a week, causes light peeling of dead surface skin together with removal at least some blemishes, imparting a youthful and healthy complexion.Type: GrantFiled: March 4, 1985Date of Patent: August 26, 1986Inventor: Richard B. Aronsohn
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Patent number: 4590183Abstract: The method of providing cytoprotection of the gastric mucosa in a mammal receiving aspirin perorally which comprises orally administering either prior to or in combination with aspirin a cytoprotectively effective amount of sodium thiosulfate alone or in combination with a pharmaceutically acceptable carrier. Also shown is a composition for providing cytoprotection of the gastric mucosa in a mammal receiving aspirin perorally which comprises aspirin in combination with a cytoprotectively effective amount of sodium thiosulfate.Type: GrantFiled: April 22, 1985Date of Patent: May 20, 1986Assignee: Sterling Drug Inc.Inventor: Denis M. Bailey
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Patent number: 4585764Abstract: The method of providing cytoprotection of the gastric mucosa in a mammal receiving aspirin (ASA) perorally which comprises orally administering either prior to or in combination with ASA a cytoprotectively effective amount of 3,3'-thiobis[propanoic acid] (TBPA) or in combination with a pharmaceutically acceptable carrier. Also shown is a composition for providing cytoprotection of the gastric mucosa in a mammal receiving ASA perorally which comprises ASA in combination with a cytoprotectively effective amount of TBPA.Type: GrantFiled: April 22, 1985Date of Patent: April 29, 1986Assignee: Sterling Drug Inc.Inventor: Denis M. Bailey
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Patent number: 4542025Abstract: An anti-inflammatory agent containing microparticle composition prepared by a process, comprising (a) dissolving or dispersing an anti-inflammatory agent in a solvent and dissolving a biocompatible and biodegradable wall forming material in said solvent; (b) dispersing said solvent containing said anti-inflammatory agent and wall forming material in a continuous phase processing medium; (c) evaporating a portion of said solvent from said dispersion of step (b), thereby forming microparticles containing said anti-inflammatory agent in the suspension; and (d) extracting the remainder of the solvent from said microcapsules.Type: GrantFiled: April 30, 1984Date of Patent: September 17, 1985Assignees: The Stolle Research and Development Corporation, Southern Research InstituteInventors: Thomas R. Tice, Danny H. Lewis, Donald R. Cowsar, Lee R. Beck
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Patent number: 4540685Abstract: The invention relates to a process for the production of pharmaceutical preparations based on 5-aminosalicylic acid in which the 5-aminosalicylic acid is mixed with physiologically and toxicologically acceptable, basic auxiliaries and/or buffer mixtures, which in a 1% aqueous solution give pH-values in the range from 8 to 12, and the mixture obtained is processed in known manner to form tablets, film tablets, dragees, capsules or suppositories, or in which the 5-aminosalicylic acid is mixed with a concentrated aqueous solution of the above-mentioned basic auxiliaries and/or buffer mixtures, the 5-aminosalicylic acid salt formed is precipitated, separated off from the aqueous solution and dried and the salt obtained is processed in known manner to form tablets, film tablets, dragees, capsules or suppositories.Type: GrantFiled: December 21, 1982Date of Patent: September 10, 1985Inventor: Kurt H. Bauer
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Patent number: RE33086Abstract: The invention relates to a process for manufacturing effervescent tablets consisting in the steps of careful humidifying of the acid+base mixture, pre-drying and final drying and granulating.It has been found that these operations can be performed in a single apparatus, either integrally in fluid bed, or with vacuum-drying.Type: GrantFiled: July 10, 1987Date of Patent: October 10, 1989Inventor: Jean Bru