With Organic Oxygen Containing Compound Patents (Class 514/164)
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Patent number: 5998392Abstract: Improved compositions of benzoyl peroxide are prepared by at least partially dissolving benzoyl peroxide in diethylene glycol monoethyl ether to prepare a premixture which forms a flocculent composition of benzoyl peroxide when admixed with water or an aqueous medium. The improved benzoyl peroxide compositions have a small particle size compared with those prepared by conventional grinding techniques and the time and potential hazards associated with grinding are avoided. The small particle size of the benzoyl peroxide flocculents result in increased surface area of active ingredient on the skin for a given concentration of benzoyl peroxide. The flocculent compositions are used to prepare compositions for the topical treatment of acne or other dermatological disorders.Type: GrantFiled: April 10, 1996Date of Patent: December 7, 1999Assignee: Gattefosse s.a.Inventors: Veronique Simard, David Garlen, Kenneth Klein
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Patent number: 5948443Abstract: The present invention pertains generally to the field of Public Health, including the prevention and treatment of coronary heart disease which is currently the first cause of death in the American population. More specifically, the present invention concerns a total modular system of multivitamin and mineral supplementation composed of 7 distinct modules for improving public health by insuring adequate intake of micronutrients needed for disease prevention and protection against nutritional losses and deficiencies due to, for example, lifestyle factors and common inadequate dietary patterns. A module, as used herein throughout, is defined as a separate and distinct combination of vitamin-mineral and other health promoting compounds which are directed to specific target populations. The formulations of the present invention which, when combined in one capsule or tablet or as separate modules, exert a joint and enhancing effect on the major pathogenetic factors involved in the atherosclerotic process.Type: GrantFiled: February 21, 1997Date of Patent: September 7, 1999Assignee: Medical Doctor's Research Institute, Inc.Inventors: Patricia A. Riley, George Christakis
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Patent number: 5856316Abstract: A mixture of higher primary aliphatic alcohols of 22 to 38 carbon atoms can be obtained by saponifying and extracting steps with organic solvents from sugar cane wax. The mixture which contains tetracosanol, hexacosanol, heptacosanol, octacosanol, nonacosanol, triacontanol, dotriacontanol and tetratriacontanol can be used for the treatment of hypercholesterolemia, and atherosclerotic complications as platelet hyperaggregabiulity, ischemia and thrombosis, and prevents drug induced gastric ulcer and improves male sexual activity.Type: GrantFiled: December 23, 1996Date of Patent: January 5, 1999Assignee: Laboratorios Dalmer SAInventors: Abilio Laguna Granja, Juan Magraner Hernandez, Daisy Carbajal Quintana, Lourdes Arruzazabala Valmana, Rosa Mas Ferreiro, Milagros Garcia Mesa
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Patent number: 5759550Abstract: An improved method for suppressing xenograft rejection in a host subject is disclosed. The method includes administering an immunosuppressant drug, where the drug or the amount of drug administered is, by itself, ineffective to suppress xenograft rejection. Effective xenograft suppression is achieved by also administering an ethanolic extract of Triterygium wilfordii or a purified triptolide component thereof.Type: GrantFiled: June 7, 1995Date of Patent: June 2, 1998Assignee: Pharmagenesis, Inc.Inventors: Tien Wen Tao Wiedmann, Jian Wang
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Patent number: 5753637Abstract: The acne treatment method of the present invention includes applying to skin a composition including an effective amount of acne treatment medication selected from the group consisting of benzoyl peroxide and salicylic acid, an effective amount of a vasoconstrictor and an inert carrier. The acne treatment medication is therapeutic to acne conditions by acting as an antibacterial agent. The vasoconstrictor removes the redness normally associated with acne conditions as well as additional redness which may be caused by the benzoyl peroxide itself. The carrier is simply an inert flowing carrier to permit the application of the active ingredients to the skin. In preferred embodiments about 1 to 15% of the acne treatment medication based on the total weight of the composition is included. The preferred acne treatment medication is benzoyl peroxide and the preferred vasoconstrictor is tetrahydrozoline hydrochloride or a combination of tetrahydrozoline hydrochloride and zinc sulfate.Type: GrantFiled: January 8, 1997Date of Patent: May 19, 1998Assignee: Ideal Ideas, Inc.Inventor: Karen G. Fried
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Patent number: 5663156Abstract: A mixture of higher primary aliphatic alcohols of 22 to 38 carbon atoms can be obtained by saponifying and extracting steps with organic solvents from sugar cane wax. The mixture which contains tetracosanol, hexacosanol, heptacosanol, octacosanol, nonacosanol, triacontanol, dotriacontanol and tetratriacontanol can be used for the treatment of hypercholesterolemia, and atherosclerotic complications as platelet hyperaggregabiulity, ischemia and thrombosis, and prevents drug induced gastric ulcer and improves male sexual activity.Type: GrantFiled: July 25, 1994Date of Patent: September 2, 1997Assignees: Laboratorios Dalmer SA, Adanifer, S.A.Inventors: Abilio Laguna Granja, Juan Magraner Hernandez, Daisy Carbajal Quintana, Lourdes Arruzazabala Valmana, Rosa Mas Ferreiro, Milagros Garcia Mesa
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Patent number: 5543405Abstract: A weight reduction composition comprises a sympathomimetic agent and a mineral cation salt or chelate capable of enhancing carbohydrate metabolism, protein or fatty acid synthesis, retarding protein breakdown or lowering serum cholesterol levels such as trivalent and hexavalent chromium and vanadium salts and chelates. Preferred is a weight reduction composition containing ephedrine and chromium picolinate. This composition is presented in a variety of formulations, and is suitable for application to the reduction of weight of normal, slightly and grossly overweight humans.Type: GrantFiled: October 20, 1994Date of Patent: August 6, 1996Inventors: Wendy J. Keown, Betty J. Ford, Sandra L. Stoddard
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Patent number: 5286720Abstract: Compositions for topical treatment of lesions of human or animal skin which comprise dimethyl ether to freeze the tissue and an acid capable of dissolving the intercellular matrix of the lesion. The dimethyl ether and acid are present in the composition in amounts effective to remove the lesion in a single treatment by a combination of cryogenic and keratolytic action. Methods are provided for the topical treatment of lesions of the skin of human or animal subjects comprising direct spray or intermediate swab application of the present compositions to the lesions.Type: GrantFiled: July 16, 1992Date of Patent: February 15, 1994Assignee: Solarcare Technologies CorporationInventors: Raymond S. Niedbala, Elizabeth A. Vail
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Patent number: 5135925Abstract: Zinc acexamate acts by increasing the synthesis of mucus, reinforces the mucous barrier, improves the microcirculation and increases the synthesis of prostaglandins in the gastric mucous membrane, whereby it is effective in the treatment of said gastropathy, contrary to the results obtained with antiacids or antisecretory agents.Type: GrantFiled: January 18, 1991Date of Patent: August 4, 1992Assignee: Laboratorios Vinas, S.A.Inventor: Antonio B. Vinas
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Patent number: 5055456Abstract: This invention is concerned with a composition of matter and method of applying same for use as hair grooming aid or preferably, to treat androgenetic alopecia comprising (a) an effective amount of a polysaccharide or mixtures thereof, polysaccharide derivatives or mixtures thereof, or any combination of the foregoing; and (b) a minor amount of a fatty acid ester of sorbitol and its anhydrides, or mixture of said fatty acid esters; and (c) a minor amount of a lower alkyl ester of p-hydroxy benzoic acid or mixture of said esters; and (d) water sufficient to create a composition of 100% by volume.Type: GrantFiled: January 27, 1989Date of Patent: October 8, 1991Assignee: American Cyanamid Co.Inventors: Bruce J. Harris, James R. Lawter, Lawrence Ritter
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Patent number: 5034221Abstract: A topical agent and method for the treatment and prevention of pseudofolliculitis barbae, commonly known as "razor bumps", is effected by the topical application to beard areas of the face of a combination of acetylsalicylic acid, corn starch, isopropyl alcohol, and aloe vera.Type: GrantFiled: June 22, 1989Date of Patent: July 23, 1991Inventors: Steven E. Rosen, Robert M. Thomas
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Patent number: 5019567Abstract: A pharmaceutical or cosmetic composition for topical application comprises, in a physiologically acceptable support, the combination of benzoyl peroxide and at least one quaternary ammonium lipophilic salicylate having general formula (I): ##STR1## where: (i) R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be identical or different, representing a substituted or interrupted alkyl or cycloalkyl radical;(ii) R.sub.3 and/or R.sub.4 represent(s) the group:R.sub.8 --OC.sub.2 H.sub.3 R.sub.7 ].sub.n [OCH.sub.2 CHOH--CH.sub.2 ].sub.pwhere O.ltoreq.n.ltoreq.4 and p is 0 or 1; R.sub.8 represents H or an alkyl, alkenyl, alkylcycloalkyl or alkylanyl radical;(iii) R.sub.4 represents an alkylenephenyl radical;(iv), (v): R.sub.1 and R.sub.2 may form an aromatic or nonaromatic saturated or unsaturated heterocycle;(vi) R.sub.1, R.sub.2 and R.sub.3 together with nitrogen, may form polycyclic derivatives; and R.sub.5 represents a group having the formula: ##STR2## where n may vary from 0 to 10.Type: GrantFiled: November 23, 1988Date of Patent: May 28, 1991Assignee: L'OrealInventors: Michel Philippe, Michel Hocquaux, Henri Sebag, Irina Beck, Jean P. Laugier
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Patent number: 4798811Abstract: A combination of verapamil, gallopamil or anipamil and acetylsalicylic acid in a weight ratio of from 10:1 to 2:1 being useful in the treatment of circulatory disorders.Type: GrantFiled: January 7, 1988Date of Patent: January 17, 1989Assignee: BASF AktiengesellschaftInventors: Hans D. Lehmann, Rolf Kretzschmar, Klaus-Juergen Hahn
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Patent number: 4778786Abstract: As a composition for transdermal drug delivery, the gelation reaction product of a mixture of an organic polysaccharide gum, polyethylene glycol, and m-, p- or o-hydroxybenzoic acid in an amount effective in forming from such mixture a gel having adhesive properties for adhesion to skin and being sufficiently pliant to conform to the shape of body contours.Type: GrantFiled: November 10, 1987Date of Patent: October 18, 1988Assignee: Minnetonka, Inc.Inventors: Richard Reever, Larry Lundmark, Timothy Kapsner
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Patent number: 4775667Abstract: Topical analgesic anti-inflammatory compositions containing a corticosteroid in addition to the conventional efficacy-proven ingredients are disclosed. They may be embodied in an aerosol, a solution and any other type of composition being convenient for administration. More than the sum of effects of the individual ingredients has been proved. In other words, the effects of the salicylate esters and L-menthol are synergistically enhanced by the addition of the corticosteroid. Particularly, the persistency of the analgesic/anti-inflammatory effects of the conventional ingredients has been proved to be dependent upon the the concentration of the corticosteroid in the composition.Type: GrantFiled: September 24, 1986Date of Patent: October 4, 1988Assignee: Shionogi & Co., Ltd.Inventors: Izumi Saitoh, Hirokuni Jyoyama, Fujio Asanuma, Katsumi Hirose, Shohei Egawa
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Patent number: 4665063Abstract: The present invention relates to a composition and to a method for the treatment of dermatological disorders such as acne, by topically applying acetyl salicyclic acid within a carrier.Type: GrantFiled: July 12, 1985Date of Patent: May 12, 1987Assignee: Rafa Laboratories Ltd.Inventor: Daniel Bar-Shalom
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Patent number: 4664915Abstract: A compressed and formed alkaline component suitable for use in a buffered aspirin product. The alkaline component is made of alkaline materials selected from the group consisting of calcium carbonate, magnesium carbonate, magnesium oxide, magnesium hydroxide and mixtures thereof and having incorporated therein citric acid and monobasic sodium phosphate.Type: GrantFiled: February 21, 1986Date of Patent: May 12, 1987Assignee: Bristol-Myers CompanyInventor: Hovsep Simonian
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Patent number: 4665088Abstract: This invention relates to compounds of the structures: ##STR1## which structure includes its isomers, conventionally designated (E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide and commonly termed (E,Z)-ajoene. This invention also relates to a process for preparing the compounds which comprises extracting and isolating allyl disulfide oxide (allyl 2-propenethiosulfinate) from the bulbs of garlic plants and thereafter treating it with a lower alkyl alcohol to produce such compound and the compounds as antibiotic and particularly as antithrombotic agents.Type: GrantFiled: November 14, 1984Date of Patent: May 12, 1987Assignee: The Research Foundation of State University of New YorkInventors: Rafael J. Apitz-Castro, Mahendra K. Jain
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Patent number: 4652557Abstract: Novel pharmaceutical solutions and particularly novel pharmaceutical solutions comprising dimethyl sulfoxide (DMSO).Type: GrantFiled: October 24, 1985Date of Patent: March 24, 1987Assignee: Clark Pharmaceutical Laboratories Ltd.Inventor: Edmund Sandborn
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Patent number: 4559329Abstract: Methylsulfonylmethane (CH.sub.3 SO.sub.2 CH.sub.3) administered orally is effective in ameliorating the symptoms of gastrointestinal upset, e.g., produced by the ingestion of aspirin and other pharmaceuticals, and of allergic reactions. Oral compositions containing a mixture of such a pharmaceutical and methylsulfonylmethane are useful in avoiding the gastrointestinal upset which otherwise occurs when ingesting the former.Type: GrantFiled: April 17, 1984Date of Patent: December 17, 1985Inventor: Robert J. Herschler
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Patent number: 4559326Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of a non-steroidal antiinflammatory agent such as prioxicam, or a pharmaceutically acceptable salt thereof, with inositol.Type: GrantFiled: January 31, 1985Date of Patent: December 17, 1985Assignee: Pfizer Inc.Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
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Patent number: 4540685Abstract: The invention relates to a process for the production of pharmaceutical preparations based on 5-aminosalicylic acid in which the 5-aminosalicylic acid is mixed with physiologically and toxicologically acceptable, basic auxiliaries and/or buffer mixtures, which in a 1% aqueous solution give pH-values in the range from 8 to 12, and the mixture obtained is processed in known manner to form tablets, film tablets, dragees, capsules or suppositories, or in which the 5-aminosalicylic acid is mixed with a concentrated aqueous solution of the above-mentioned basic auxiliaries and/or buffer mixtures, the 5-aminosalicylic acid salt formed is precipitated, separated off from the aqueous solution and dried and the salt obtained is processed in known manner to form tablets, film tablets, dragees, capsules or suppositories.Type: GrantFiled: December 21, 1982Date of Patent: September 10, 1985Inventor: Kurt H. Bauer
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Patent number: 4514385Abstract: Anti-acne preparations include finely divided, dispersed particles of benzoyl peroxide and finely divided, dispersed particles of salicylic acid in an aqueous gel formed from carboxy vinyl polymer resins. The gels are prepared without loss of salicylic acid by fully hydrating the resin in an aqueous medium and allowing the resin to gel in the absence of an alkaline neutralizing agent.Type: GrantFiled: October 5, 1981Date of Patent: April 30, 1985Assignee: Alcon Laboratories, Inc.Inventors: Nalinkant C. Damani, Haresh G. Bhagat, Ramon L. McElhaney
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Patent number: 4511563Abstract: The subject invention relates to analgesic gels which comprise1. from 5 to 15 parts of an analgesic compound;2. from 10 to 40 parts of a nonionic surfactant which forms a gel in water alone at about 15 to 30 percent by weight based upon the weight of the water plus the weight of the nonionic surfactant;3. from 5 to 40 parts of glycerin;4. from 40 to 75 parts of water; and5. optional ingredients (q.v.)said parts based upon 100 parts of the composition and provided that the weight ratio of nonionic surfactant to water is from 5:1 to 3:1.The subject gels are clear, water soluble and are not tacky when applied to the skin.Type: GrantFiled: July 15, 1983Date of Patent: April 16, 1985Assignee: BASF Wyandotte CorporationInventor: Irving R. Schmolka