Abstract: The present invention relates generally to paints and paint bases, and, more specifically to a process and composition for providing a stable gel-free dispersion of zinc pyrithione plus cuprous oxide biocide in paint. In accordance with the process of the present invention, the paint or paint base contains a metal salt of wood rosin in order to impart desired gelation-inhibition to the paint.

Abstract: The present invention relates generally to paints and paint bases, and, more specifically to a process and composition for providing a stable gel-free dispersion of zinc pyrithione plus cuprous oxide biocide in paint. In accordance with the process of the present invention, the paint or paint base contains an amine compound or esterified wood rosin in order to impart desired gelation-inhibition to the paint.

Abstract: Compounds in which two or more rings, being a 3-hydroxpypyrid-2-one, 3-hydroxypyrid-4-one or 1-hydroxpyrid-2-one, are linked are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body while the iron complexes of such compounds are of value in the treatment of iron deficiency anaemia.

Abstract: Hypoxic cells are rendered more sensitive to irradiation by subjecting the cells to treatment with a Cu(II) coordination compound.

Abstract: A metal complex having the general formula (I): ##STR1## wherein R.sup.1 is C.sub.1-4 alkoxy, C.sub.1-4 haloalkoxy, or C.sub.2-4 alkenyloxy; R.sup.2 is hydrogen or cyano; R.sup.3 is hydrogen or methyl; X is oxygen or sulphur; M.sub.p Y.sub.q is a transition metal salt wherein M is a transition metal cation, Y is an anion and p and q are independently 1, 2 or 3 according to valency requirements; and n is 1 or 2. The metal complexes of formula (I) are active as fungicides.

Abstract: The present invention relates generally to paints and paint bases, and, more specifically to a process for providing a stable gel-free dispersion of zinc pyrithione plus cuprous oxide biocide in paint. In accordance with the process of the present invention, the zinc pyrithione is purified to a purity assay of at least 98% in order to provide gellation-inhibition in the paint.

Abstract: The administration of chromic picolinate, preferably in the form of chromic tripicolinate, as a prophylactic or therapeutic agent for controlling various blood serum parameters. In particular, the administration is for controlling blood serum lipid levels, including the lowering of undesirably high blood serum LDL-cholesterol levels and the raising of blood serum HDL-cholesterol levels. Additionally, the adminstration is for controlling desirable high blood serum glucose levels, this being particularly applicable for the treatment of maturity-onset diabetes. Additionally, chromic picolinate, preferably in the form of chromic tripicolinate, is admistered to facilitate uptake of amino acids by skeletal muscle. Thus chromic picolinate can act as an effective anabolic agent.

Abstract: The administration of chromic picolinate, preferably in the form of chromic tripicolinate, as a prophylactic or therapeutic agent for controlling various blood serum parameters. In particular, the administration is for controlling blood serum lipid levels, including the lowering of undesirably high blood serum LDL-cholesterol levels and the raising of blood serum HDL-cholesterol levels. Additionally, the administration is for controlling undesirable high blood serum glucose levels, this being particularly applicable for the treatment of maturity-onset diabetes. Additionally, chromic picolinate, preferably in the form of chromic tripicolinate, is administered to facilitate uptake of amino acids by skeletal muscle. Thus chromic picolinate can act as an effective anabolic agent.

Abstract: The invention relates to medicine.A composition for treatment of progressive myopia is composed of the following constituents, taken in mass percent:______________________________________ a mixture of polyvinylpyrrolidone, acrylamide- 18.8 to 29.5 hydrazide, and ethylacrylate (1;1;1) an aqueous solution, containing the follow- 69.5 to 80.1 ing ingredients, taken in mg/l: hydrochloric acid 940.0 boric acid 4.12 ferrous oxide 115.0 cupric citrate 16.0 3-percent aqueous hydrogen peroxide 0.79 to 0.89 dichlorodi-[ 2-methyl-3-hydroxy-4,5-di- 0.11 to 0.31.

Abstract: A method for improving the growth response in poultry comprising administering to said poultry a growth-promoting amount of at least one pyridine-2-thione-N-oxide compound selected from the group consisting of(a) a metallic salt of pyridine-2-thione-N-oxide;(b) 2,2'-dithiobispyridine-1,1'-dioxide; and(c) adducts of 2,2'-dithiobispyridine-1,1'-dioxide, the adducts having the formula(C.sub.5 H.sub.4 NOS).sub.2 MY.sub.twherein M is an alkaline earth metal selected from the group consisting of calcium, magnesium, barium and strontium, Y is an anion selected from the group consisting of halides, sulfates, nitrates, chlorates and acetates, and t is either 1 or 2.

Abstract: This invention relates to an improved paint or paint base composition characterized by enhanced biocidal efficacy. The paint or paint base composition is essentially free of tin, lead, and vanadium and contains a biocide comprising pyrithione salt and a copper salt. The pyrithione salt is present in the paint in an amount of between about 5% and about 50%, and the copper salt is present in an amount of between about 5% and about 50%, the total amount of biocide being between about 10% and about 75%, based upon the total weight of the paint composition.

Abstract: A zinc complex of lysocellin is provided. The complex acts as a coccidiostat and growth-promoting agent when administered to poultry.

Abstract: Platinum amine sulfoxide complexes of the formula [PtCl(diam)(R.sub.2 SO)].sup.+ X.sup.- wherein diam represents a bidentate amine, R is C.sub.3 -C.sub.7 alkyl or cycloalkyl and X.sup.- is an anion, exhibit favorable anti-tumor activity in vivo against tumors susceptible to therapy with platinum.

Abstract: An antihyperlipidemic pharmaceutical or dietary supplement composition for oral use consisting essentially of a combination of niacin and a gel-forming dietary fiber, and a method of lowering cholesterol levels with such oral pharmaceutical composition, or by the simultaneous oral administration of the active ingredients thereof, which eliminates the usual undesirable flushing and itching side effects of niacin while effectively lowering cholesterol levels, especially LDL cholesterol levels, is disclosed.

Abstract: Disclosed herein are analgesic copper coordination compounds and a process for using them in the treatment of analgesia in animal bodies. The copper coordination compounds utilized are the reaction products of copper salts with:1. carboxylic acids or their alkaline earth salts;2. aromatic carboxylic acids or their alkaline earth salts;3. heterocyclic carboxylic acids or their alkaline earth salts;4. amino acids or their alkaline earth salts;5. anthranilic acids or their alkaline earth salts;6. salicyclic acids or their alkaline earth salts;7. acetylsalicylates or their alkaline earth salts;8. arylacetic acids or their alkaline earth salts;9. disubstituted aminodithiocarbamates, and mixtures of any of the above.The process disclosed comprises administering to animals, orally or parenterally, in controlled dosages, the aforementioned copper coordination compounds.

Abstract: A pesticidal composition includes an active ingredient mixed with an inert ingredient comprising dried sweet corn as a substantial portion thereof. The dried sweet corn is preferably ground, mixed with the active ingredient and then provided in pelleted, granular or meal form.

Abstract: An antihyperlipidemic pharmaceutical or dietary supplement composition for oral use consisting essentially of a combination of niacin and guar gum, and a method of lowering cholesterol levels with such oral pharmaceutical composition, or by the simultaneous oral administration of the active ingredients thereof, which eliminates the usual undesirable flushing and itching side effects of niacin while effectively lowering cholesterol levels, especially LDL cholesterol levels, is disclosed.

Abstract: A novel product obtained by reacting an alkali metal salt of nicotinic acid with a trivalent chromium salt and having glucose tolerance factor activity, a process for its production and a method for its use, are disclosed.

Abstract: The present invention relates to copper complexes exhibiting superoxide dismutase-like activity in mammalian cells. The copper complexes, which act as superoxide radical (O.sub.2.sup.-) scavengers, are used in treating cancer by replacing the lost superoxide dismutase activity which characterizes tumor systems. The low molecular weight and lipid solubility of the copper complexes facilitate penetration of cell membranes. Depending upon the specific type of copper complex used, treatment may result in decreased tumor growth, increased survival of the host organism, decreased tumor metastasis or induced morphological differentiation of cancerous cells. The copper complexes used according to the invention include copper salicylate complexes, their solvates as well as mixtures thereof. A method for the treatment of cancer using these copper complexes is also disclosed.

Abstract: A novel product obtained by reacting an alkali metal salt of nicotinic acid with a trivalent chromium salt and having glucose tolerance factor activity, a process for its production and a method for its use, are disclosed.

Abstract: There is described a novel class of aminegold(III) complexes in which the nitrogen-containing ligand is an alkylamine, an arylamine or a heterocyclic amine. Said complexes are useful in the treatment of tumors in mammals.

Abstract: Substituted azolylcyclopropyl-azolylmethyl-carbinol derivatives of the formula ##STR1## in which Ar is optionally substituted aryl or optionally substituted heteroaryl,R is hydrogen, alkyl, alkenyl, alkinyl, trialkylsilyl, optionally substituted phenylalkyl or an acyl radical, andX and Y each independently is a nitrogen atom or a CH group,and addition products thereof with acids and metal salts are effective in regulating plant growth and combating fungi. New intermediates are described, some of which are themselves active.

Abstract: A bis-platinum complex having the structure: ##STR1## wherein X and Y are the same or different ligands and are halide, sulphate, phosphate, nitrate, carboxylate, substituted carboxylate or dicarboxylate. B and C are the same or different and are primary or secondary amines, or pyridine type nitrogens. A is a diamine or polyamine wherein the primary amine N atoms are coordinated to the Pt atom such that platinum is present as Pt.sup.2+. The complexes are useful in the inhibition of tumors.

Abstract: Neutral 2:1 ligand:zinc(II) complexes in which at least one ligand is provided by a compound being 3-hydroxy-4-pyrone or a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms are of value for use in effecting an enhancement of the oxygen binding ability of a patient's haemoglobin, this being of particular application in the treatment of sickle cell disease.

Abstract: A pyrazole oxime derivative represented by the general formula (I) which is useful as an insecticide and fungicide, ##STR1## wherein the structural elements are defined in the specification, and the method of controlling said pests. The compounds represented by the general formula (I) can be synthesized by the methods disclosed in the specification.

Abstract: A compound of the general formula I(BH.sub.n).sub.m [RuX.sub.3+nm-q-r.sup.(OH).sub.r (BH.sub.p).sub.3-nm+q ].sub.1+p+q IwhereinB denotes a mononuclear or polynuclear basic heterocyclic radical containing one or more nitrogen atoms,X denotes chlorine or bromine,m denotes 1 or 2,n denotes 1 or 2, the sum of n and m being not greater than 3,p denotes 0 or 1, but not 1 if n is 1,q denotes 0 or 1, but not 1 if p is 1 andr denotes 0 or 1,show an antitumoral activity and are therefore suitable as a chemotherapeutic for the treatment of cancers.

Abstract: A composition of matter comprising a metal pyrethione salt, an amine having the following formulaH.sub.x N((CH.sub.2).sub.y X).sub.zwherein x is 0 to 2, y is 1 to 3, z is 1 to 3, x+z=3 and X is H, OH or COOH and an aminocarboxylic acid selected from the group consisting of ethylenediaminetetraaceteic acid, diethylenetriaminepentaacetic acid, nitrilotriacetic acid, N(hydroxide ethyl) ethylenediaminetriacetic acid, cyclohexanediamine tetracetic acid, triethanolamine ethylenediamine tetracetic acid and acids having the formulas: ##STR1## where X is H, lithium, sodium, potassium, cesium, magnesium, calcium, nickel, copper, zinc and mixtures thereof. A is H or COOX and n is an integer or zero.

Abstract: A polyvalent metal salt of 2-mercaptopyridine-N-oxide (Mept compound) is dispersed in water by aid of a specific dispersant selected from the group consisting of (A), (B) and (C):(A) A polyglycol/polyamine condensation polymer, polyglycol/polyamine/alkylamine condensation polymer or alkyleneamine condensation polymer;(B) At least one water-soluble polymer compound selected from the group consisting of hydroxyalkylcelluloses and partly quaternarized products thereof, and at least one non-ionic surfactant;(C) At least one cationic polymer compound and at least one inorganic salt.The resulting suspension has improved stability and is applicable to shampooes, hair rinses and the like.

Abstract: A bis-platinum complex having the structure: ##STR1## wherein X and Y are the same or different ligands and are halide, sulphate, phosphate, nitrate, carboxylate, substituted carboxylate or dicarboxylate. B and C are the same or different and are primary or secondary amines, or pyridine type nitrogens. A is a diamine or polyamine wherein the primary amine N atoms are coordinated to the Pt atom such that platinum is present as Pt.sup.2+. The complexes are useful in the inhibition of tumors.

Abstract: The invention provides compounds of the general formula ##STR1## and physiologically acceptable salts and hydrates thereof, in which one of R.sub.1 and R.sub.2 represents hydrogen, halogen or a C.sub.1-4 alkyl group which may be optionally substituted by hydroxy or C.sub.1-4 alkoxy, and the other represents the group R.sub.4 R.sub.5 NAlk-- in which Alk represents a straight or branched alkylene chain of 1 to 6 carbon atoms;R.sub.3, which may be in either the 2 or 3-position, represents the ##STR2## where X represents --CH.sub.2 --, --O-- or --S--; n represents zero, 1 or 2;m represents 2, 3 or 4; andR.sub.7 represents hydrogen, alkyl, alkenyl, aralkyl, or C.sub.2-6 alkyl substituted by hydroxy or alkoxy; andR.sub.8 represents hydrogen, alkyl, alkenyl, aralkyl, hydroxyalkyl, acyloxyalkyl, alkoxyalkyl, aryloxyalkyl, aralkyloxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, hydroxy or alkoxy, or the group NR.sub.10 R.sub.11 ; with the provisos thatwhere R.sub.2 represents the group R.sub.4 R.sub.

Abstract: Copper-dependent enzymes are required for normal brain development and function. Copper deficiency can result in pathological disorders accompanied by convulsive seizures or tremors in man and animals. The present invention is directed to a method for treating convulsions or epilepsy comprising administration of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity. Those compounds include copper complexes of carboxylic acids, acylsalicylates, salicylates, amino acids, imines and known anticonvulsant and antiepileptic drugs.

Abstract: Copper-dependent enzymes are required for normal brain development and function. Copper deficiency can result in pathological disorders accompanied by convulsive seizures or tremors in man and animals. The present invention is directed to a method for treating convulsions or epilepsy comprising administration of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity. These compounds include copper complexes of carboxylic acids, acylsalicylates, salicylates, amino acids, imines and known anticonvulsant and antiepileptic drugs.

Abstract: Compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and Y have the indicated meanings, their physiologically tolerated acid addition salts, and a process for the preparation of these compounds, are described. The compounds inhibit thromboxane synthetase and can thus be used as medicaments.

Abstract: Compounds of the formula ##STR1## wherein Het is a 5- or 6-membered aromatic heterocyclic ring containing 1 to 2 ring nitrogen atoms and the remaining ring atoms carbon atoms optionally substituted with 1 to 2 substituents independently selected from halo, nitro, trihalomethyl, lower alkyl of 1 to 3 carbon atoms, or lower alkoxy of 1 to 3 carbon atoms; R is alkyl of 1 to 7 carbon atoms; R.sup.1 is aryl of 6 to 10 carbon atoms, lower alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, all optionally substituted with 1 to 3 halogen atoms; and a is 0 or 1 are fungicidal and insecticidal, with the proviso that a ring nitrogen is not bonded to the hydroxamic acid ##STR2## moiety.

Abstract: Hypoxic cells are rendered more sensitive to destruction by X-rays or other high energy radiation by treatment with cobalt or iron coordination compounds.

Abstract: This disclosure describes platinum complexes of heterocyclic-1,2-diamines which possess the property of inhibiting the growth of tumors in mammals.

Abstract: Polyvalent metal salts of 2-mercaptopyridine-N-oxide which are made into fine powder in which particles having a size below 0.2 micron are contained in amounts not smaller than 50 wt %.Preparing process of the above and antibacterial compositions comprising the above are also disclosed.When the finely powdered polyvalent metal salts of 2-mercaptopyridine-N-oxide are incorporated into shampoo or rinse compositions, dispersion stability of the salts is remarkably improved with the enhanced adsorbability of the particles on the skin and hair, thus antibacterial and dandruff-removing actions owing to the salts are further improved.

Abstract: Zinc(II) complexes in which at least one ligand is provided by a compound being:(1) 3-hydroxy-4-pyrone or a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms; or(2) a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydro

Abstract: A compressed powder formulation which consists essentially of an organophilic clay and at least one topical agent. The formulation maintains its physical integrity upon handling thereby permitting the preparation of the formulation in the form of self-supporting sticks and exhibits an acceptable level of payout. Additionally, the formulation retains an acceptable level of payout even when contacted with water. A process of making the formulation by compressing a powderous mixture is also set forth.

Abstract: This invention relates to novel transition metal complexes of 2-acetyl- and -propionylpyridine thiosemicarbazones, their selenium analogs. These compounds are useful as antimalarial and antileukemic agents. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones and their selenium analogs.

Abstract: This invention relates to novel antimicrobial systems containing a water-soluble, non-ionic pyrethione derivative known chemically as the magnesium sulfate adduct of 2,2'-dithiobis-pyridine-1,1'-dioxide (referred to hereinafter as "the magnesium sulfate adduct") and a water soluble zinc salt.The antimicrobial systems of this invention may be incorporated in various useful therapeutic and cleansing compositions such, for example, as surgical scrub compositions, skin disinfectants, mouthwashes, deodorants, hospital cleaners, etc.

Abstract: Pharmaceutical compositions containing an iron complex of a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by aliphatic hydrocarbon groups, are of value for the treatment of iron deficiency anemia.

Abstract: Novel triazolylmethyl-pyridyloxymethyl-carbinols of the formula ##STR1## in which R is optionally substituted alkyl, optionally substituted cycloalkyl or optionally substituted phenyl,Y is halogen, alkyl, alkoxy or cyano, andm is 0, 1, 2, 3 or 4,or addition products thereof with acids or metal salts, which possess fungicidal activity.

Abstract: Certain species of fungi are controlled by ethene derivatives of the formula: ##STR1## wherein one of Ar.sup.1 and Ar.sup.2 is one of certain N-heterocyclic moieties and the other is halogen-substituted phenyl, R.sup.1 is hydrogen or alkyl and R.sup.2 is --CN or --C(O)XR, wherein X is oxygen or sulfur and R.sup.1 has a defined meaning.

Abstract: Compounds which are a 1-hydroxypyrid-2-one in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by a substituent selected from aliphatic acyl, aliphatic amide, aliphatic amine, carboxy, cyano, aliphatic ester, halogen, hydroxy and sulpho groups, alkoxy groups and alkoxy groups substituted by an alkoxy, aliphatic amide, aliphatic amine, aliphatic ester, halogen or hydroxy group, aliphatic hydrocarbon groups and aliphatic hydrocarbon groups substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by substituents selected from aliphatic hydrocarbon groups, halogen groups and aliphatic hydrocarbon groups substituted by a halogen group, or a salt thereof containing a physiolgically acceptable ion or ions, are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body whilst the iron complexes of such compounds are of val

Abstract: A composition of matter comprising a major part of imidazolidinyl urea and a minor part of pyrithione and/or one or more derivatives of pyrithione is disclosed. The composition exhibits synergistic anti-microbial activity.

Abstract: Certain novel bipyridine substituted compounds, their metal complexes (Cu, Fe and Ni) which are effective to improve feed efficiency and promote growth in food-producing animals, particularly ruminants. The compounds are described by the general formula ##STR1## including the cupric, nickelous and ferrous salts thereof.

Abstract: Pharmaceutical compositions containing an iron complex of a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic hydrocarbon group and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are also replaced by an aliphatic hydrocarbon group, are of value for the treatment of iron deficiency anemia.

Abstract: This invention relates to novel antimicrobial systems containing a water-soluble, non-ionic pyrethione derivative known chemically as the magnesium sulfate adduct of 2,2'-dithiobis-pyridine-1,1'-dioxide (referred to hereinafter as "the magnesium sulfate adduct") and a water soluble zinc salt.The antimicrobial systems of this invention may be incorporated in various useful therapeutic and cleansing compositions such, for example, as surgical scrub compositions, skin disinfectants, mouthwashes, deodorants, hospital cleaners, etc.

Abstract: The levels of essential metals in the mammalian system can be precisely controlled by administering these metals in the form of exogenously synthesized coordination complexes of picolinic acid. The complexes are characterized by the following structural formula: ##STR1## wherein M represents the metallic cation and n is equal to the cation's valence.