Hetero Ring Is Six-membered Consisting Of One Nitrogen And Five Carbons Patents (Class 514/188)
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Patent number: 6958359Abstract: Vanadium compounds for inhibiting angiogenesis useful for treating or preventing diabetic retinopathy, hemangiomas, cancers with abnormal blood vessel supply, restenosis following vascular injury, and the like.Type: GrantFiled: November 15, 2000Date of Patent: October 25, 2005Assignee: Parker Hughes InstituteInventor: Fatih M. Uckun
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Patent number: 6955873Abstract: The present invention relates to a kit and an intervenously administrable preparation, both, with a signal transmitter precursor, an enhancer of precursor uptake, and an inhibitor of neurotransmitter reuptake or signal transmitter catabolism. The kit also contains an appropriate swab for obtaining oral cells suitable for allelic analysis. The intervenous formulation contains similar materials and, in some cases, ethanol. Either the kit composition or the intervenous formulation may be used as guided by a subjects allelic analysis. Collections of particular alleles, especially those relating to neural system are comprehensible in terms of likelihood of success in the administration of an interveinous formulation or ingestion of components of the subject kit.Type: GrantFiled: August 4, 2000Date of Patent: October 18, 2005Inventor: Kenneth Blum
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Patent number: 6939532Abstract: Dye-peptide conjugates useful for diagnostic imaging and therapy are disclosed. The dye-peptide conjugates include several cyanine dyes with a variety of bis- and tetrakis(carboxylic acid) homologues. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350-1300 nm, the exact range being dependent upon the particular dye. Use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The molecules of the invention are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities and for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.Type: GrantFiled: January 9, 2001Date of Patent: September 6, 2005Assignee: Mallinckrodt, Inc.Inventors: Samuel I. Achilefu, Raghavan Rajagopalan, Richard B. Dorshow, Joseph E. Bugaj
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Patent number: 6908912Abstract: The present invention is directed to a stable, soluble, antimicrobial composition concentrate comprising pyrithione or a pyrithione complex in an amount of from about 0.5% to about 30 weight percent, a zinc source in an amount of from about 0.1% to about 10%, and an organic amine component in an amount of from about 30% to about 80%, said percents being based upon the total weight of the composition concentrate. The invention is also directed to methods of controlling the growth of free-living microorganisms or biofilms using the antimicrobial composition of the invention, and products made using the antimicrobial composition of the invention.Type: GrantFiled: December 20, 2002Date of Patent: June 21, 2005Assignee: Arch Chemicals, Inc.Inventors: Michelle L. Rioux, Diana T. Ciccognani, Thomas J. Palys, Patricia A. Turley
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Patent number: 6878388Abstract: Vanadium compounds useful to prevent and/or inhibit adhesion, migration, and invasion of proliferative cells into surrounding tissue.Type: GrantFiled: November 15, 2000Date of Patent: April 12, 2005Assignee: Parker Hughes InstituteInventors: Fatih M Uckun, Rama Krishna Narla
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Patent number: 6867217Abstract: The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.Type: GrantFiled: May 18, 2000Date of Patent: March 15, 2005Assignee: Pharmacia CorporationInventors: Michael S. South, Qingping Zeng, Ashton T. Hamme, II, Melvin L. Rueppel
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Patent number: 6849613Abstract: A method for administering an antioxidant composition to humans according to their age and sex is disclosed wherein the method comprises administering to said humans a daily dose of a multiple antioxidant micronutrient composition comprising vitamin A (palmitate), beta carotene (from natural d. salina), vitamin C (calcium ascorbate), vitamin D-3 (cholecalciferol), natural source vitamin E including both d-alpha tocopheryl and d-alpha tocopheryl acid succinate, thiamine mononitrate, riboflavin, niacinamide ascorbate, d-calcium pantothenate, pyridoxine hydrochloride, cyanocobalamin, folic acid (folacin), d-biotin, selenium (1-seleno methionine), chromium picolinate, zinc glycinate, calcium citrate, and magnesium citrate. For persons over the age of about 51, the composition preferably further comprises one or more of co-enzyme Q10, N-acetyl cysteine, and alpha lipoic acid. Preferably, also, vitamin D is added for women over the age of about 36.Type: GrantFiled: August 28, 2002Date of Patent: February 1, 2005Inventors: Kedar N. Prasad, Gerald M. Haase
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Patent number: 6846777Abstract: The invention relates to a biocidal composition which can be added to materials which can be attacked by harmful micro-organisms, containing pyrithione as a biocidal active ingredient. The biocidal composition is characterised in that it contains 2-alkyl isothiazoline-3-one as another biocidally active ingredient. The active ingredients of the biocidal composition behave synergistically and are ideally suitable for controlling bacteria, fungus and algae.Type: GrantFiled: August 20, 2001Date of Patent: January 25, 2005Assignee: Thor GmbHInventors: Dagmar Antoni-Zimmermann, Rüdiger Baum, Thomas Wunder, Hans-Jürgen Schmidt
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Patent number: 6835371Abstract: Piperazine or piperidine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The piperazine or piperadine compounds are characterized by the formula:Formula I wherein: A is oxygen; n is an integer of 1 to 6; X and Y can be the same or different and are hydrogen, halogen, nitro, alkyl or halalkyl, Z is carbon or nitrogen; and &phgr; is phenyl, naphthyl, thienyl or pyridinyl. When Z is carbon, R is hydrogen, cyano, hydroxy, —COOCH3, —CH20H or —COOH; R1 is 4-fluorophenyl, 4-chlorophenyl, 4-trifluoromethyl, 3-trifluoromethyl-4 -chlorophenyl 4-bromophenyl), 4-(2-keto-1-benzimidazolinyl or 1-phenyl 1, 3, 8-triazaspiro [4,5] decan-4-one.Type: GrantFiled: August 7, 2000Date of Patent: December 28, 2004Inventors: David R. Elmaleh, Choi Sung-Woon
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Patent number: 6833362Abstract: A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or “pseudo” enzymes for the oxidation. Additives include the oxidant Nicotinamide Adenine Dinucleotide and a variety of other additives such as transition metal ions and complexes thereof which favor the oxidation reaction. The compositions described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.Type: GrantFiled: June 7, 2001Date of Patent: December 21, 2004Inventors: Ward Beryl Bowen, Jr., Daniel Salman Daniel
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Patent number: 6831077Abstract: The present invention relates to pharmaceutical compositions comprising an atypical antipsychotic agent in combination with a chromium salt, which are used for treating atypical depression, as well as minimizing side effects in a patient taking an atypical antipsychotic agent.Type: GrantFiled: July 25, 2002Date of Patent: December 14, 2004Assignee: Comprehensive Neuroscience, Inc.Inventor: John Docherty
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Patent number: 6821326Abstract: Disclosed herein is a composition comprising a non-dusting copper pyrithione dispersion comprising small solid particles of copper pyrithione dispersed in a liquid dispersant, said solid particles having a particle size within a range of from about 0.1 to about 10 microns and a median particle size of less than 3 microns. The dispersion is suitably employed as an antifouling additive for marine paints without risking worker exposure to copper pyrithione dust. Paints containing the small particle copper pyrithione exhibit improved antifouling performance in cold water, as compared to paint containing larger particle copper pyrithione.Type: GrantFiled: December 20, 2002Date of Patent: November 23, 2004Assignee: Arch Chemicals, Inc.Inventors: Craig Waldron, Robert J. Martin, Sonia R. Oberson, Christopher J. Bannon
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Patent number: 6812247Abstract: A metal complex and its use for binding or cleaving a nucleic acid. The metal complex has the formula: M is Pt, Pd, Ni, Co, or Cu; X is aryl, heteroaryl, cyclyl, or heterocyclyl; Y is halogen, tosylate, mesylate, triflate, pyrophosphate, or carboxylate; each of A1 and A2, independently, is N or C; each of A3 and A4, independently, is N, S, or O, wherein A1, A2, A3, and A4 taken together have one positive charge; and each of R1 and R2, independently, is alkyl, aryl, heteroaryl, alkoxyl, aryloxyl, heteroaryloxyl, alkoxylcarbonyl, aryloxylcarbonyl, or heteroaryloxylcarbonyl.Type: GrantFiled: September 30, 2002Date of Patent: November 2, 2004Assignee: Academia SinicaInventors: Kuang-Lieh Lu, Jih-Ru Hwu, Shwu-Chen Tsay, Sheng-Fa Yu, Jui-Te Hung, Jiann-Jyh Huang
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Patent number: 6777405Abstract: Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions characterized by the presence of polynucleotide errors or damage are treated with such compounds that are capable of catalyzing polynucleotide cleavage with light.Type: GrantFiled: September 3, 2002Date of Patent: August 17, 2004Assignee: California Institute of TechnologyInventors: Jacqueline K. Barton, Brian A. Jackson, Brian P. Hudson
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Patent number: 6753016Abstract: A method for the protection of wood and other wood materials without affecting dimensional stability or surface integrity of the treated material is described. The method involves treating wood material with an iron salt and selected oxidants where the iron salt is preferably complexed with organic chelating ligands. Preferably, a microbicidal agent is also incorporated into the method to provide treated wood products that demonstrate excellent surface integrity, dimensional stability and retention of the infused microbicidal agents for extended periods of time without incurring the detrimental environmental effects of conventional chromium or copper-based inorganic salt preservation methods.Type: GrantFiled: June 6, 2002Date of Patent: June 22, 2004Assignee: Rohm and Haas CompanyInventor: Tirthankar Ghosh
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Patent number: 6750251Abstract: Compounds which may be used in the treatment and/or prevention of cancer have the formula (I) wherein: R1, R2, R3, R4, R5 and R6 independently represents H, alkyl, —CO2R′, aryl or akylaryl, which latter two groups are optionally substituted on the aromatic ring; R′ represent alkyl, aryl or alkaryl; X is halo, H2O, (R′)(R″)SO, R′CO2— or (R′)(R″)C═O, where R″ represents alkyl, aryl or alkaryl; Y is a counterion; m is 0 or 1; q is 1, 2 or 3; C′ is C1 to C12 alkylene, optionally substituted in or on the alkylene chain, bound to two A groups; p is 0 or 1 and r is 1 when p is 0 and r is 2 when p is 1; and A and B are: each independently N-donor nitrile ligands; or B is halo and A is an N-donor pyridine ligand, optionally substituted at one or more of the carbon atoms of the pyridine ring; or p is 0, A is NR7R8 and B is NR9R10, wherein R7, R8, R9 and R10 independently represent H or alkyl, and A and B are linked by an alkylene chain, optionally sType: GrantFiled: April 26, 2002Date of Patent: June 15, 2004Assignee: The University Court, The University of Edinburgh (UK)Inventors: Robert Edward Morris, Peter John Sadler, Haimei Chen, Duncan Jodrell
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Patent number: 6743786Abstract: The invention provides methods for treating cancer and compounds that are useful for the treatment of tumors, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates useful for preparing the compounds.Type: GrantFiled: May 8, 2002Date of Patent: June 1, 2004Assignee: Parker Hughes InstituteInventors: Fatih M. Uckun, Yanhong Dong, Phalguni Gosh
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Patent number: 6713469Abstract: Compositions comprising chromic tripicolinate or chromic polynicotinate in combination with at least one of a cyclooxygenase inhibitor, an acid, a mucolytic and a salicin-containing herb. The compositions are useful for supplementing dietary chromium, lowering blood glucose levels, lowering serum lipid levels and increasing lean body mass.Type: GrantFiled: July 25, 2002Date of Patent: March 30, 2004Assignee: Ambi Inc.Inventors: Jon de la Harpe, Fredric D. Price, Lawrence W. Chakrin, James R. Komorowski, Lauren K. Skluth
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Patent number: 6693094Abstract: The invention describes formulations that include either metformin, sulfonylurea or a biguanide-sulfonylurea combination as one active ingredient in addition to specific, other active ingredients. The compositions and dosage forms of the invention are clinically useful as methods for increasing the effectiveness, efficiency and safety of the included biguanide (metformin) and/or sulfonylurea in the prevention and treatment of insulin resistance and diabetes mellitus. The carefully chosen additional active ingredients of the invention are designed in a modular fashion to prevent and rectify adverse events associated with insulin resistance syndrome and diabetes mellitus, and those adverse incidences associated with the concurrent use of metformin and/or the sulfonylureas. When clinically administered, the invention will provide therapeutic levels of metformin and of a sulfonylurea, alone or in combination, and broaden their usefulness.Type: GrantFiled: March 7, 2002Date of Patent: February 17, 2004Assignee: Chrono RX LLCInventors: Don C. Pearson, Kenneth T. Richardson
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Patent number: 6689774Abstract: The present invention provides methods and compositions comprising one or more zinc ionophores for protecting tissue from the harmful effects of apoptosis in patients in need thereof. Concentrations of zinc-pyrithione and diethyldithiocarbamate in the picomolar to nanomolar range have a strong protective effect against apoptosis.Type: GrantFiled: July 26, 2002Date of Patent: February 10, 2004Assignee: Zinc Therapeutics, Canada Inc.Inventor: Henry Fliss
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Patent number: 6670456Abstract: Actinium-225 complexes comprising functionalized polyazamacrocyclic chelant compounds are disclosed. Such complexes show improved stability and can be conjugated to a biological carrier.Type: GrantFiled: February 27, 2002Date of Patent: December 30, 2003Assignee: Dow Global Technologies Inc.Inventors: R. Keith Frank, Garry E. Kiefer, Jaime Simon
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Patent number: 6667339Abstract: Vanadium (IV) complexes containing a substituted or unsubstituted catecholate ligand, and the spermicidal activity of such compounds. Preferred compounds are vanadocene (IV) complexes containing alkyl substituted catecholate ligands.Type: GrantFiled: July 23, 2002Date of Patent: December 23, 2003Assignee: Parker Hughes InstituteInventors: Phalguni Ghosh, Faith M. Uckun, Osmond D′Cruz
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Patent number: 6664248Abstract: Compounds of formula wherein A is an unsubstituted or substituted aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical wherein a ring nitrogen atom may have been replaced by a group R1 is hydrogen or C1-C3alkyl; R2 is hydrogen or C1-C3alkyl; R3 is hydrogen an unsubstituted or substituted C1-C6alkyl, C3-C6cycloalkyl, C2-C6alkenyl or C2-C6alkynyl group, or C(═O)—R5, R5 is C1-C4alkyl, C1-C4alkoxy, an unsubstituted or substituted phenyl, phenoxy or benzyloxy group, or N(R6)2, each R6, independently of the other, is hydrogen, C1-C4alkyl or unsubstituted or substituted phenyl, X is CH—NO2, N—CN or N—NO2 and n is from 1 to 3, in free form or in salt form, and, where appropriate, tautomers of those compounds and the salts thereof, can be used as agrochemical active ingredients and can be prepared in a manner known per seType: GrantFiled: January 13, 2003Date of Patent: December 16, 2003Assignee: Syngenta Investment Corp.Inventors: Peter Maienfisch, Jozef Gonda, Olivier Jacob, Laurenz Gsell
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Patent number: 6642221Abstract: Vanadium compounds as anti-proliferative agents. These compounds act to disrupt mitotic and meiotic spindle formation and thus are useful to prevent cell mitosis (proliferation) and meiosis.Type: GrantFiled: November 15, 2000Date of Patent: November 4, 2003Assignee: Parker Hughes InstituteInventors: Faith M Uckun, Christopher S Navara
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Patent number: 6627665Abstract: The present invention is directed to a non-dusting copper pyrithione dispersion, comprising an admixture of: from about 20 to about 99 wt % of copper pyrithione; from about 0.05 to about 30 wt % of a dust-inhibiting agent selected from the group consisting of surfactants, polymer resins, binders, and combinations thereof; and from about 0.05 wt. % to about 80 wt % of a dispersant; wherein all weight percents are based on the total weight of the dispersion.Type: GrantFiled: September 28, 2001Date of Patent: September 30, 2003Assignee: Arch Chemicals, Inc.Inventors: Craig Waldron, Patrick Hobbs
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Patent number: 6608050Abstract: The present invention relates to a pharmaceutically acceptable dosage form of water insoluble porphyrins, particularly metal containing porphyrins such as tin porphyrin, which can be complexed with a lipid, reconstituted from a lyophilizate and administrated to a patient in the treatment of cancer and other diseases.Type: GrantFiled: October 4, 2001Date of Patent: August 19, 2003Assignee: Pharmacia & Upjohn CompanyInventors: Mathew Cherian, Shireesh Prakash Apte
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Publication number: 20030119805Abstract: The present invention provides methods and compositions comprising one or more zinc ionophores for protecting tissue from the harmful effects of apoptosis in patients in need thereof. Concentrations of zinc-pyrithione and diethyldithiocarbamate in the picomolar to nanomolar range have a strong protective effect against apoptosis.Type: ApplicationFiled: July 26, 2002Publication date: June 26, 2003Inventor: Henry Fliss
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Patent number: 6579866Abstract: A nutritional supplement composition for modulating nutrient partitioning in a human so as to increase oxidation of fat and promote increased storage of glycogen is composed of hydroxycitric acid, carnitine, biotin, a gluconeogenic substrate, and, optionally, one or more of chromium, conjugated linoleic acid, coenzyme Q10, eicosapentaenoic acid, pyridoxine, alpha-lipoic acid, magnesium, and gymnema sylvestre. A method for modulating nutrient partitioning in a human involves orally or parenterally administering the aforementioned composition to the human, preferably on a daily basis, for a therapeutically effective period of time. Preferably, the method further involves having the human follow a specific dietary regimen wherein the glycemic index is less than 60 and the daily calorie consumption from carbohydrates is less than about 50% and the daily calorie consumption from protein is at least about 20%.Type: GrantFiled: December 28, 2000Date of Patent: June 17, 2003Inventor: Larry McCleary
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Patent number: 6558666Abstract: A chromium(III)-containing carbohydrase enzyme food supplement composition providing at least one cellulase fungal enzyme, at least one alpha amylase fungal enzyme, at least one hemicellulase fungal enzyme, at least on chromium(III) compound, and, optionally, at least one acceptable carrier.Type: GrantFiled: April 3, 2002Date of Patent: May 6, 2003Assignee: Triarco Industries, Inc.Inventor: Mark L. Anderson
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Publication number: 20030083325Abstract: The present invention is directed to a new class of serotonin 5HT2 antagonists and thier use in the treatment of a variety of diseases.Type: ApplicationFiled: June 21, 2002Publication date: May 1, 2003Inventors: Thaddeus R. Nieduzak, Mark W. Dudley, John H. Kehne
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Patent number: 6534493Abstract: &agr;- and &bgr;-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.Type: GrantFiled: October 24, 2000Date of Patent: March 18, 2003Assignee: G.D. SearleInventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
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Patent number: 6528502Abstract: A nutritional supplement for use in managing carbohydrates and enhancing anabolism in mammals is described. The nutritional supplement contains regulated amounts of niacin, chromium, and vanadium, and optionally thiamin, riboflavin, magnesium, and zinc. These vitamins and minerals mimic and/or enhance the physiological effects of insulin in the body. A method of using the composition is also described.Type: GrantFiled: August 8, 2000Date of Patent: March 4, 2003Assignee: Metagenics, Inc.Inventors: Kim Carleton Krumhar, Jeffrey J. Katke
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Patent number: 6518428Abstract: The present invention relates to the area of platinum drugs.Type: GrantFiled: April 11, 2000Date of Patent: February 11, 2003Assignee: Anormed, Inc.Inventors: Ernest S. Y. Wong, Christen M. Gianomenico
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Patent number: 6506770Abstract: The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.Type: GrantFiled: July 8, 1998Date of Patent: January 14, 2003Assignee: AnorMED, Inc.Inventors: Gary James Bridger, Eva Maria Boehringer, Zhongren Wang, Dominique Schols, Renato Tony Skerlj, David Earl Bogucki
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Patent number: 6495538Abstract: The present invention provides methods and compositions comprising one or more zinc ionophores for protecting tissue from the harmful effects of apoptosis in patients in need thereof. Concentrations of zinc-pyrithione and diethyldithiocarbamate in the picomolar to nanomolar range have a strong protective effect against apoptosis.Type: GrantFiled: January 12, 2001Date of Patent: December 17, 2002Assignee: Zinc Therapeutics, Canada Inc.Inventor: Henry Fliss
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Patent number: 6471998Abstract: Compositions comprising chromic tripicolinate or chromic polynicotinate in the form of enteric-coated tablets, capsules or microbeads, optionally in combination with nicotinic acid, picolinic acid or both nicotinic acid and picolinic acid. The compositions are useful for supplementing dietary chromium, lowering blood glucose levels, lowering serum lipid levels and increasing lean body mass.Type: GrantFiled: May 4, 2001Date of Patent: October 29, 2002Assignee: Ambi, Inc.Inventors: Jon de la Harpe, Fredric D. Price, Lawrence W. Chakrin, James R. Komorowski, Lauren K. Skluth
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Patent number: 6468987Abstract: An enteral nutritional product for a person having ulcerative colitis contains in combination (a) an oil blend which contains eicosapentaenoic acid (20:5n3) and/or docosahexaenoic acid (22:6n3), and (b) a source of indigestible carbohydrate which is metabolized to short chain fatty acids by microorganisms present in the human colon. Preferably the nutritional product also contains one or more nutrients which act as antioxidants.Type: GrantFiled: September 14, 1999Date of Patent: October 22, 2002Assignee: Abbott LaboratoriesInventors: Stephen Joseph Demichele, Keith Allen Garleb, John William McEwen, Martha Kay Fuller
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Patent number: 6465450Abstract: Vanadium (IV) complexes containing a substituted or unsubstituted catecholate ligand, and the spermicidal activity of such compounds. Preferred compounds are vanadocene (IV) complexes containing alkyl substituted catecholate ligands.Type: GrantFiled: September 19, 2001Date of Patent: October 15, 2002Assignee: Parker Hughes InstituteInventors: Phalguni Ghosh, Fatih M. Uckun, Osmond D'Cruz
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Patent number: 6458833Abstract: A metal complex and its use for binding or cleaving a nucleic acid. The metal complex has the formula: M is Pt, Pd, Ni, Co, or Cu; X is aryl, heteroaryl, cyclyl, or heterocyclyl; Y is halogen, tosylate, mesylate, triflate, pyrophosphate, or carboxylate; each of A1 and A2, independently, is N or C; each of A3 and A4, independently, is N, S, or 0, wherein A1, A2, A3, and A4 taken together have one positive charge; and each of R1 and R2, independently, is alkyl, aryl, heteroaryl, alkoxyl, aryloxyl, heteroaryloxyl, alkoxylcarbonyl, aryloxylcarbonyl, or heteroaryloxylcarbonyl.Type: GrantFiled: November 20, 2001Date of Patent: October 1, 2002Assignee: Academia SinicaInventors: Kuang-Lieh Lu, Jih-Ru Hwu, Shwu-Chen Tsay, Sheng-Fa Yu, Jui-Te Hung, Jiann-Jyh Huang
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Patent number: 6444661Abstract: Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions characterized by the presence of polynucleotide errors or damage are treated with such compounds that are capable of catalyzing polynucleotide cleavage with light.Type: GrantFiled: November 23, 1999Date of Patent: September 3, 2002Assignee: California Institute of TechnologyInventors: Jacqueline K. Barton, Brian A. Jackson, Brian P. Hudson
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Patent number: 6432942Abstract: Compositions comprising chromic tripicolinate or chromic polynicotinate in combination with at least one of a cyclooxygenase inhibitor, an acid, a mucolytic and a salicin-containing herb. The compositions are useful for supplementing dietary chromium, lowering blood glucose levels, lowering serum lipid levels and increasing lean body mass.Type: GrantFiled: May 4, 2001Date of Patent: August 13, 2002Assignee: AMBI Inc.Inventors: Jon de la Harpe, Fredric D. Price, Lawrence W. Chakrin, James R. Komorowski, Lauren K. Skluth
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Patent number: 6432941Abstract: The invention provides methods for treating cancer and vanadium compounds that are useful for the treatment of tumors, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates useful for preparing the compounds.Type: GrantFiled: August 20, 1999Date of Patent: August 13, 2002Assignee: Parker Hughes InstituteInventors: Fatih M. Uckun, Yanhong Dong, Phalguni Gosh
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Patent number: 6432432Abstract: A method for producing a suspension, emulsion or dispersion of de-agglomerated particles (advantageously submicron-sized particles) of pyrithione salts comprising contacting agglomerated pyrithione salt particles with a de-agglomerating agent to produce the desired de-agglomerated pyrithione salt particles. Also disclosed is a method for making de-agglomerated submicron-sized particles of pyrithione salts comprision a heating step. Also disclosed are the particles made by the above methods and compositions comprising the particles and a base medium.Type: GrantFiled: February 25, 2000Date of Patent: August 13, 2002Assignee: Arch Chemicals, Inc.Inventors: Saeed M. Mohseni, Charles W. Kaufman, David C. Beaty, John J. Jardas, George Polson
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Patent number: 6426096Abstract: A method of treating carbohydrate craving in a human patient comprises administering to the patient an anorexigenic composition comprising a compound which elevates serotonin levels in the brain of the patient, typically hypercin, found in St John's Wort Extract, or sibutramine, in a mixture with a physiologically acceptable metabolisable chromium compound. The chromium compound is selected from chromium picolinate, chromium polynicotinate, chromium chelate, chromium proteinate, or any other bioavailable chromium compound. The mixture optionally includes laevorotary carnitine or a racemic mixture of carnitine.Type: GrantFiled: May 16, 2000Date of Patent: July 30, 2002Inventor: Paolina Galvao
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Patent number: 6413953Abstract: An improved platinum(IV) compound and its application as an antitumor agent are disclosed.Type: GrantFiled: October 4, 2000Date of Patent: July 2, 2002Assignee: AnorMED Inc.Inventors: Christen M. Gianomenico, Ernest S. Y. Wong
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Patent number: 6407090Abstract: The present invention provides methods and compositions comprising one or more zinc ionophores for blocking apoptosis in patients in need thereof. Concentrations of zinc-pyrithione and diethyldithiocarbamate in the picomolar to nanomolar range have a strong protective effect against apoptosis.Type: GrantFiled: June 23, 2000Date of Patent: June 18, 2002Assignee: Zinc Therapeutics Canada, Inc.Inventor: Henry Fliss
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Publication number: 20020049190Abstract: A compound of the formulaType: ApplicationFiled: March 17, 2000Publication date: April 25, 2002Inventors: Gary J. Bridger, Beth R. Cameron, Simon P. Fricker, Michael J. Abrams, Renato Skerlj, Ian Baird
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Patent number: 6350740Abstract: The invention provides a method for enhancing the water solubility of cytotoxic trans-platinum complexes. The present invention also provides a method for killing tumor cells, and a method for the treatment of tumors by the administration of a cytotoxic platinum coordination complex of the general formula SP4-2-[PtX(L)(L′)(B)]+.Type: GrantFiled: September 5, 2000Date of Patent: February 26, 2002Assignee: Virginia Commonwealth UniversityInventor: Nicholas Farrell
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Publication number: 20020013306Abstract: A new class of 2,2′:6′,2″-terpyridine-platinum (II) and substituted 2,2′:6′,2″-terpyridine-platinum (II) complexes in which an N— or O— or halo nucleophile is the fourth ligand to platinum. The compounds are potent intercalators of DNA. Some have antitumour activity. Some have anti-parasitic activity. A new method of preparing the complexes involves reacting a Pt complex of 1,5-cyclooctadiene with a 2,2′:6′,2″-terpyridine.Type: ApplicationFiled: July 13, 1998Publication date: January 31, 2002Inventor: GORDON LOWE
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Patent number: 6329360Abstract: The hetero-linked phenylglycinolamides are prepared by reaction of the corresponding hetero-linked phenylacetic acids with appropriate phenylglycinols. The hetero-linked phenylglycinolamides are suitable as active compounds in medicaments.Type: GrantFiled: September 18, 2000Date of Patent: December 11, 2001Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Ulrich Müller, Richard Connell, Hilmar Bischoff, Dirk Denzer, Rudi Grützmann, Martin Beuck