Isoalloxazine (e.g., Riboflavins, Vitamin B2, Etc.) Patents (Class 514/251)
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Patent number: 6159476Abstract: Athletic performance may be improved by administering a composition comprising galanthamine as an active ingredient to an athlete before and during sports activities. Also provided is an herbal sports performance composition comprising whole plant extract of Leucojum aestivum.Type: GrantFiled: January 10, 2000Date of Patent: December 12, 2000Assignee: HerbaceuticalsInventors: Atanas Russinov Djananov, Tricia Grose
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Patent number: 6159505Abstract: Compositions for the treatment and prevention of migraine or stress headaches wherein there is supplied a combination of potassium, magnesium and pyridoxine optionally in association with other nutrients and/or simple analgesics.Type: GrantFiled: January 21, 1998Date of Patent: December 12, 2000Inventor: Edwina M. Piper
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Patent number: 6150364Abstract: Purified and crystallized riboflavin is prepared by a process that includes dissolving needle-shaped riboflavin of the stable modification A form in an aqueous mineral acid solution at a temperature not exceeding about 30.degree. C. with intensive intermixing. Active charcoal is then added to the resulting solution. After adsorption of the dissolved impurities from the solution onto the active charcoal, the solution containing the active charcoal is subjected to counter-current filtration over a ceramic membrane having a pore size of about 20 to about 200 nm. The resulting filtrate is treated with a five- to ten-fold amount of water (vol./vol.) at a temperature not exceeding about 30.degree. C. The resulting precipitated, spherical crystals of riboflavin are then separated by centrifugation or filtration. If desired, the spherical crystals of riboflavin may be washed with water and subsequently dried.Type: GrantFiled: October 19, 1999Date of Patent: November 21, 2000Assignee: Roche Vitamins Inc.Inventor: Gerhard Wagner
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Patent number: 6147054Abstract: A composition for cosmetic, pharmaceutical or dietetic use and including as the active ingredient, at least one of the substances which include acetylglucosamine and glucuronic acid in combination with the active ingredients which belong to the chemical class of the carboxylic acids, .alpha.-hydroxy acids, vitamins, amino acids, and bioflavonoids, and formulated with particular synergists, additives, and excipients for external use or for internal use.Type: GrantFiled: November 17, 1997Date of Patent: November 14, 2000Inventor: Gianfranco De Paoli Ambrosi
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Patent number: 6093715Abstract: Process for producing riboflavin granules or riboflavin microgranules with a riboflavin content of from 90 to 99.5% by weight and with a particle size range from 50 to 450 .mu.m, which entails adding during the granulation at least one auxiliary selected from the group consisting of alkali metal and alkaline earth metal halides, alkali metal and alkaline earth metal carbonates, alkali metal and alkaline earth metal bicarbonates, alkali metal and alkaline earth metal phosphates, crosslinked cellulose and cellulose derivatives and crosslinked polyvinylpyrrolidone in amounts of from 0.5 to 10% by weight, all % by weight data being based in each case on the dry product.Type: GrantFiled: March 24, 1999Date of Patent: July 25, 2000Assignee: BASF AktiengesellschaftInventors: Hans-Peter Harz, Loni Schweikert, Douglas Norbert Schmidt
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Patent number: 6077543Abstract: Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions of the components and spray drying them simultaneously in a spray dryer. The hydrophilic and hydrophobic component are separately dissolved in separate solvents and directed simultaneously through a nozzle, usually a coaxial nozzle, into the spray dryer. The method provides dry powders having relatively uniform characteristics.Type: GrantFiled: December 29, 1997Date of Patent: June 20, 2000Assignee: Inhale Therapeutic SystemsInventors: Marc S. Gordon, Andrew Clark, Thomas K. Brewer
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Patent number: 6020333Abstract: The invention relates to the field of therapeutic chemistry and concerns novel antiviral pharmaceutical compositions for the local prevention of diseases of the genital and rectal mucus membranes. The compositions are characterized in that that the active ingredient used is riboflavin or one of the mineral or organic acid or FAD addition salts thereof. The active ingredient further comprises niacin or NAD or NADP. Vitamin factors can also be added such as carotene, flavonoids, acetyloenzyme A and vitamins A, E, C, B6, B8 or F. Fillers such as insoluble barium salts, titanium derivatives, alkaline-earth silicates, aluminium silicates, mineral or organic bismuth salts, insoluble zinc salts, rare earth derivatives, zirconium derivatives, can be added to said compositions to reinforce the mucus adhesiveness of said preparations. Vegetable extracts containing flavonoids or anthocyanosides can be further incorporated into the pharmaceutical compositions of the invention.Type: GrantFiled: December 18, 1995Date of Patent: February 1, 2000Inventor: Jean Berque
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Patent number: 6017919Abstract: The compounds of the formula (I) ##STR1## wherein each symbol is as defined in the specification, pharmaceutically acceptable salts thereof and pharmaceutical use thereof. The Compound (I) and pharmaceutically acceptable salts thereof of the present invention selectively act on cannabinoid receptors, particularly peripheral receptors, cause less side effects on the central system, and have superior immunoregulating action, antiinflammatory action, antiallergic action and therapeutic effect on nephritis. Therefore, they are useful as cannabinoid receptor, particularly peripheral cannabinoid receptor activators and antagonists, immunoregulators, therapeutic agents for autoimmune diseases, antiinflammatory agents, antiallergic agents and therapeutic agents for nephritis.Type: GrantFiled: August 6, 1998Date of Patent: January 25, 2000Assignee: Japan Tobacco Inc.Inventors: Takashi Inaba, Tetsudo Kaya, Hiroyuki Iwamura
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Patent number: 5958464Abstract: A composition for preventing and treating milk fever in freshening cows, and a method of administering the composition. The basic composition is a mixture of water, calcium chloride, propylene glycol, B vitamins and minerals. The calcium content is lower than conventional calcium treatments used for this purpose. The propylene glycol gives the cow an energy boost and sweetens the taste so the cow does not object to it as it does to conventional gels and liquids. The B vitamins stimulate the cow's appetite. The minerals replace minerals lost in the milk and also help the cow absorb calcium. The composition of the present invention is in a liquid form and is preferably administered using a 200-300 cc drench gun. The end of the dispensing tube of the drench gun is placed between the teeth and cheek of the cow near the receptors that stimulate the esophageal groove reflex.Type: GrantFiled: November 12, 1997Date of Patent: September 28, 1999Inventor: Jack W. Register
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Patent number: 5948443Abstract: The present invention pertains generally to the field of Public Health, including the prevention and treatment of coronary heart disease which is currently the first cause of death in the American population. More specifically, the present invention concerns a total modular system of multivitamin and mineral supplementation composed of 7 distinct modules for improving public health by insuring adequate intake of micronutrients needed for disease prevention and protection against nutritional losses and deficiencies due to, for example, lifestyle factors and common inadequate dietary patterns. A module, as used herein throughout, is defined as a separate and distinct combination of vitamin-mineral and other health promoting compounds which are directed to specific target populations. The formulations of the present invention which, when combined in one capsule or tablet or as separate modules, exert a joint and enhancing effect on the major pathogenetic factors involved in the atherosclerotic process.Type: GrantFiled: February 21, 1997Date of Patent: September 7, 1999Assignee: Medical Doctor's Research Institute, Inc.Inventors: Patricia A. Riley, George Christakis
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Patent number: 5945420Abstract: An immunopotentiating and infection protective agent comprising riboflavin and/or a riboflavin derivative, which is safe for the human, animals or the like, an immunopotentiating and infection protective agent comprising riboflavin and/or a riboflavin derivative and (1) proline and/or glutamine, (2) an antibiotic, or (3) a water-soluble polymer or lecithin, which is safe for the human, animals or the like, and a process for the production thereof.Type: GrantFiled: April 15, 1998Date of Patent: August 31, 1999Assignee: Eisai Co., Ltd.Inventors: Seiichi Araki, Mamoru Suzuki, Masatoshi Fujimoto
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Patent number: 5888552Abstract: This invention relates to a method of treatment of patients having lesions resulting from cancer cells and to an application as an anti-cancer composition of undenatured whey protein concentrate.Type: GrantFiled: May 8, 1995Date of Patent: March 30, 1999Assignee: Immunotec Research Corporation Ltd.Inventors: Gustavo Bounous, Phil Gold
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Patent number: 5817314Abstract: A novel saponin component having a molecular weight of about 956 daltons, a process for isolating the saponin component from the bark of Quillaja saponaria Molina, a vaccine formulation comprising the saponin component as an immune adjuvant, a method for increasing the immune response to an antigen by employing an adjuvant composition comprising saponin component and a second adjuvant.Type: GrantFiled: December 6, 1996Date of Patent: October 6, 1998Assignee: LG Chemical Ltd.Inventors: Hong-Seob So, Hye-Sung Yoon, Young-Sun Kwon, Joong-Myung Cho
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Patent number: 5814632Abstract: An immunopotentiating and infection protective agent comprising riboflavin and/or a riboflavin derivative, which is safe for the human, animals or the like, an immunopotentiating and infection protective agent comprising riboflavin and/or a riboflavin derivative and (1) proline and/or glutamine, (2) an antibiotic, or (3) a water-soluble polymer or lecithin, which is safe for the human, animals or the like, and a process for the production thereof.Type: GrantFiled: April 12, 1995Date of Patent: September 29, 1998Assignee: Eisai Co., Ltd.Inventors: Seiichi Araki, Mamoru Suzuki, Masatoshi Fujimoto
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Patent number: 5780446Abstract: The present invention relates to methods of treating, as well as preventing extravasation injury. In particular, the present invention pertains to photochemotherapeutic methods of prophylaxis and/or treatment of extravasation injury induced by vesicant antineoplastic drugs and other pharmaceutical formulations. In accordance with the present invention, extravasation injury is prevented or minimized by the coadministration of photoinactivation inducing compounds in a formulation comprising a vesicant antineoplastic or other pharmaceutical formulation, and subsequently exposing the injection or infusion site to photoexciting light.Type: GrantFiled: July 9, 1996Date of Patent: July 14, 1998Assignee: Baylor College of MedicineInventor: Avner Ramu
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Patent number: 5770233Abstract: An object of the present invention is to provide an infusion preparation set (a container filled with infusion liquids) useful for preparation of an infusion liquid containing sugars, amino acids, electrolytes, a fat emulsion and vitamins. The present invention is constituted by the use of a container having two compartments which are separated from each other by a separation means, which contains an infusion liquid comprising a fat emulsion, sugars, fat-soluble vitamins and specified water-soluble vitamins in the first compartment and an infusion liquid comprising amino acids, electrolytes and other specified water-soluble vitamins in the second compartment. An infusion preparation containing sugars, amino acids, electrolytes, a fat emulsion and vitamins can be obtained easily and aseptically upon use, by simply removing a separation means and mixing the infusion liquids included in the first and second compartments.Type: GrantFiled: April 21, 1995Date of Patent: June 23, 1998Assignee: The Green Cross CorporationInventors: Takae Kido, Shigeo Ii, Shun-ichi Abe, Kazumasa Yokoyama
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Patent number: 5763392Abstract: Method for lowering the plasma glucose levels of diabetics by administering myo-inositol. Also the invention concerns a nutritional composition containing myo-inositol.Type: GrantFiled: May 15, 1996Date of Patent: June 9, 1998Inventors: Barbara C. Hansen, Harry L. Greene, Heidi K. Ortmeyer
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Patent number: 5728681Abstract: A container filled with infusion liquids useful for preparation of an infusion liquid containing sugars, amino acids, electrolytes, a fat emulsion and vitamins. A container having two compartments which are separated from each other by a separation means, which contains an infusion liquid comprising a fat emulsion, sugars and specific vitamins in the first compartment and an infusion liquid comprising amino acids, electrolytes and other specific vitamins in the second compartment. An infusion preparation containing sugars, amino acids, electrolytes, a fat emulsion and vitamins can be obtained easily and aseptically upon use, by simply removing a separation means and mixing the infusion liquids included in the first and second compartments.Type: GrantFiled: December 20, 1995Date of Patent: March 17, 1998Assignee: The Green Cross CorporationInventors: Takae Kido, Hideto Kodaira, Koji Munechika, Shigeo Ii, Shunichi Abe, Kazumasa Yokoyama
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Patent number: 5719134Abstract: A dietary composition comprising, based on total caloric content of the composition,a) a carbohydrate component which comprises from 50 to 65% of the total caloric content;b) a lipid component which comprises from 20 to 35% of the total caloric content; andc) an amino acid component which comprises from 10 to 20% of the total caloric content and which comprises specified amino acids and amounts thereof is useful providing nutrition to human adolescents.Type: GrantFiled: September 17, 1996Date of Patent: February 17, 1998Assignee: Novartis Nutrition AGInventors: Mary K. Schmidl, Carol J. Lowry
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Patent number: 5719133Abstract: A dietary composition comprising, based on total caloric content of the composition,a) a carbohydrate component which comprises from 50 to 65% of the total caloric content;b) a lipid component which comprises from 20 to 35% of the total caloric content; andc) an amino acid component which comprises from 10 to 20% of the total caloric content and which comprises specified amino acids and amounts thereof is useful providing nutrition to human adolescents.Type: GrantFiled: September 21, 1994Date of Patent: February 17, 1998Assignee: Novartis Nutrition AGInventors: Mary K. Schmidl, Carol J. Lowry
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Patent number: 5691341Abstract: Apoptosis regulating compositions each comprising a member selected from a series of carbostyril derivatives and salts thereof, inclusive of carbostyril derivatives of general formula (1) ##STR1## and salts thereof, as an active ingredient are provided. The apoptosis regulating compositions of the invention are of use as anticancer agents, antiretrovirus agents, therapeutic agents for autoimmune diseases, therapeutic agents for thrombocytopenia, therapeutic agents for Alzheimer's disease, therapeutic agents for diseases of the liver, and cancer metastasis inhibitors, among others.Type: GrantFiled: August 29, 1995Date of Patent: November 25, 1997Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hideo Tanaka, Hitomi Iba, Kazuyoshi Kawai, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito, Michiaki Tominaga, Masakazu Adachi
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Patent number: 5686429Abstract: The present invention provides a method for providing nutrition to elderly patients. Pursuant to the present invention, the enteral composition includes a protein source, a lipid source, and a carbohydrate source. Preferably, the protein source includes at least 18% of the total calories. In an embodiment, the carbohydrate source includes a source of dietary fiber including a balance of soluble to insoluble fiber ratio of approximately 1:3. Still further, the composition of the present invention also includes increased levels of certain vitamins and minerals.Type: GrantFiled: December 17, 1996Date of Patent: November 11, 1997Assignee: Nestec LtdInventors: Paul M. Lin, Shen-Youn Chang, Chris Kruzel
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Patent number: 5639482Abstract: The present invention is a method of treating diabetic retinopathy and a means for preventing its reoccurence. This is accomplished by supplementing the diet of the diabetic with approximately 1000 mcg sodium selenite and 1000 IU vitamin E on a daily basis for between 24 and 35 days until the visual acuity of the diabetic improves. Thereafter a daily maintenance supplement of 250 mcg sodium selenite and 400 IU vitamin E can be used. In the initial supplement, 1000 mcg selenonthianone or 1000 mcg selenium yeast can be used although it is less effective and requires 2000 IU of vitamin E for positive results.Type: GrantFiled: November 10, 1993Date of Patent: June 17, 1997Inventor: Ely J. Crary
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Patent number: 5637591Abstract: Disclosed are chemical agents with unexpected antimicrobial activity against the microbes, especially Porphyromonas gingivalis, known to be important in the cause and progression of gingivitis, periodontitis, and destruction of hard and soft oral tissues leading to tooth loss. The agents have additional unexpected anticollagenase activity useful in the direct mitigation of tissue damage. The agents can be formulated to produce various compositions and dental implements useful in management of peridental diseases, particularly those involving infection with certain gram-negative anaerobes.Type: GrantFiled: June 2, 1995Date of Patent: June 10, 1997Assignee: Fuji ImmunoPharmaceuticals Corp.Inventors: Mitsunori Ono, Y.-S. Edmond Cheng, Douglas F. Marks, Jr., Hiroshi Kataguchi
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Patent number: 5637616Abstract: A method for the topical or systemic treatment of disorders mediated by proteases which result in skin or mucosal lesions, and in particular, pemphigus, cicatricial pemphigoid, bullous pemphigoid, lichen planus, and canker sores, is disclosed wherein the host is treated with an effective amount of N-acetyl ysteine or a derivative thereof, or its pharmaceutically acceptable salt, optionally in a pharmaceutically acceptable diluent or carrier for systemic or topical delivery.Type: GrantFiled: October 5, 1993Date of Patent: June 10, 1997Assignee: Arcturus Pharmaceutical CorporationInventors: Richard J. Sharpe, Maureen H. McAloon, Stephen J. Galli, Kenneth A. Arndt
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Patent number: 5599840Abstract: A nutritional composition, adapted for consumption by mammals, contains (1) an orally ingestible diluent or carrier, except an oily carrier or diluent which comprises C.sub.8-18 saturated fatty acids, oleic acid and derivatives of these acids, and (2) a composition of matter which consists of (a) from about 13.0 to about 27.5% by weight of at least one compound selected from linolenic acid and its salts, esters and amides, calculated as the free acid, and (b) about 87.0 to about 72.5% by weight of at least one compound selected from linoleic acid and its salts, esters and amides thereof, calculated as the free acid, the salts, esters and amides of linolenic and linoleic acid being both physiologically hydrolyzable and pharmacologically acceptable. The invention also relates to a method for treating a mammal for the purpose of inducing therein at least one physiological effect selected from memory enhancement and analgesia, by administration of an effective amount of the nutritional composition.Type: GrantFiled: November 13, 1995Date of Patent: February 4, 1997Assignee: Bar Ilan UniversityInventor: Shlomo Yehuda
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Patent number: 5589468Abstract: The present invention provides a method for providing nutrition to elderly patients. Pursuant to the present invention, the enteral composition includes a protein source, a lipid source, and a carbohydrate source. Preferably, the protein source includes at least 18% of the total calories. In an embodiment, the carbohydrate source includes a source of dietary fiber including a balance of soluble to insoluble fiber ratio of approximately 1:3. Still further, the composition of the present invention also includes increased levels of certain vitamins and minerals.Type: GrantFiled: January 13, 1995Date of Patent: December 31, 1996Assignee: Clintec Nutrition Co.Inventors: Paul M. Lin, Shen-Youn Chang, Chris Kruzel
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Patent number: 5502050Abstract: Inhibitor of the use of tetrahydrobiopterin as a cofactor for nitric oxide synthase, e.g., substituted 4-phenyl(hydropyridines) such as 1-methyl-4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine or, 4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine) or tetrahydropterin analog which does not replace tetrahydrobiopterin as a substrate for nitric oxide synthase such as (6R,S)-6,7-dimethyl-tetrahydropterin or (6R,S)-tetrahydrofolic acid or 2,4-diamino-, 2,6-diamino, or 4,6-diamino mono- or disubstituted pyrimidines or the corresponding pyrimidine-3-oxides such as 2,4-diamino-6-(diethylamino)pyrimidine, 2,4-diamino-6-piperidino-pyrimidine-3-oxide, 2,4-diamino-6-hydroxypyrimidine, 4,6-diamino-2-hydroxypyrimidine or 2,5-diamino-4,6-dihydroxypyrimidine is administered to inhibit nitric oxide synthesis from arginine in vascular cells in a subject in need of such inhibition (e.g., for prophylaxis or treatment of cytokine- or endotoxin-induced hypotension (e.g., septic shock).Type: GrantFiled: November 29, 1993Date of Patent: March 26, 1996Assignee: Cornell Research Foundation, Inc.Inventor: Steven S. Gross
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Patent number: 5468776Abstract: A composition of matter which consists of (a) from about 16.7 to about 22.2% by weight of at least one compound selected from the group consisting of linolenic acid and derivatives thereof, calculated as the free acid, said derivatives of linolenic acid being both physiologically hydrolyzable and pharmacologically acceptable, and (b) about 77.8 to about 83.3% by weight of at least one compound selected from the group consisting of linoleic acid and derivatives thereof, calculated as the free acid, said derivatives of linoleic acid being both physiologically hydrolyzable and pharmacologically acceptable, is utilized e.g. as a pharmaceutical formulation or nutritional composition, in absence of an oily carrier or diluent which comprises at least one member of the group consisting of C.sub.Type: GrantFiled: July 20, 1993Date of Patent: November 21, 1995Assignee: Bar Ilan UniversityInventor: Shlomo Yehuda
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Patent number: 5464833Abstract: Apoptosis regulating compositions each comprising a member selected from a series of carbostyril derivatives and salts thereof, inclusive of carbostyril derivatives of general formula (1) ##STR1## and salts thereof, as an active ingredient are provided. The apoptosis regulating compositions of the invention are of use as anticancer agents, antiretrovirus agents, therapeutic agents for autoimmune diseases, therapeutic agents for thrombocytopenia, therapeutic agents for Alzheimer's disease, therapeutic agents for diseases of the liver, and cancer metastasis inhibitors, among others.Type: GrantFiled: April 19, 1994Date of Patent: November 7, 1995Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hideo Tanaka, Hitomi Iba, Kazuyoshi Kawai, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito, Michiaki Tominaga, Masakazu Adachi
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Patent number: 5451412Abstract: The present invention is concerned with a whey protein composition comprising a suitable concentration of whey protein concentrate wherein the whey protein concentrate contains proteins which are present in an essentially undenatured state and wherein the biological activity of the whey protein concentrate is dependent on the overall amino acid and small peptides pattern resulting from the contribution of all its protein components and a method of producing said whey protein composition. The invention also relates to several applications of said composition.Type: GrantFiled: June 29, 1993Date of Patent: September 19, 1995Assignee: Immunotech Research Corporation, Ltd.Inventors: Gustavo Bounous, Phil Gold, Patricia A. L. Kongshavn
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Patent number: 5431925Abstract: Disclosed is a nutritive composition for patients being treated with anticancer drugs, which comprises 1-5 mg weight % of a retinoid compound in the solid content of the composition composed of proteins, carbohydrates, fats, vitamins and minerals as major components. It can prevent the immunosuppression induced by the administration of anticancer drugs, and can prevent the infectious diseases arising from said immunosuppression and helps to enhance the therapeutic effect on the patients.Type: GrantFiled: January 24, 1994Date of Patent: July 11, 1995Assignee: Snow Brand Milk Products Co., Ltd.Inventors: Toshihiro Ohmori, Minoru Yanai
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Patent number: 5416114Abstract: A composition of matter which consists of (a) from about 13.0 to about 27.5% by weight of at least one compound selected from the group consisting of linolenic acid and derivatives thereof, calculated as the free acid, said derivatives or linolenic acid being both physiologically hydrolyzable and pharmacologically acceptable, and (b) about 87.0 to about 72.5% by weight of at least one compound selected from the group consisting of linoleic acid and derivatives thereof, calculated as the free acid, said derivatives of linoleic acid being both physiologically hydrolyzable and pharmacologically acceptable, is utilized e.g. as a pharmaceutical formulation or nutritional composition, in absence of an oily carrier or diluent which comprises at least one member of the group consisting of C.sub.Type: GrantFiled: July 20, 1993Date of Patent: May 16, 1995Assignee: Bar Ilan UniversityInventor: Shlomo Yehuda
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Patent number: 5360824Abstract: The improved cleansing cream has a wrinkle-reducing effect when periodically applied to and rubbed into the human skin in wrinkled skin areas. The cream is non-irritating to the skin and includes a plurality of water-soluble granules which are of sufficient size, quantity and hardness to abrade the keratinized outer epidermal layer of the skin. The granules may be one or more inorganic salt, but preferably include one or more water-soluble vitamins and/or water-soluble vitamin-yielding salts, The cream also includes a base in which the granules are substantially uniformly disposed. The base preferably is in a major proportion with respect to the granules and is an oil and a petrolatum jelly. The water-soluble granules do not clog the pores of the skin but are absorbed into and nourish the skin.Type: GrantFiled: February 5, 1993Date of Patent: November 1, 1994Inventor: Donald E. Barker
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Patent number: 5326757Abstract: The present invention relates to formulations and methods for preventing and treating restenosis following angioplasty. This is accomplished by the regimented administration of a composition which includes selected antioxidants.Type: GrantFiled: August 18, 1993Date of Patent: July 5, 1994Assignee: Health Maintenance Programs, Inc.Inventor: Harry B. Demopoulos
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Patent number: 5306485Abstract: Disclosed are sunscare compositions having enhanced substantivity, efficacy and the like for protecting the skin from the harmful effects of ultraviolet irradiation, such as sunburn and sun-induced premature aging of the skin.Type: GrantFiled: February 11, 1993Date of Patent: April 26, 1994Assignee: Richardson-Vicks Inc.Inventors: Larry R. Robinson, Marie A. Rinaldi, Anil J. Gupte
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Patent number: 5290571Abstract: The present invention is concerned with a whey protein composition comprising a suitable concentration of whey protein concentrate wherein the whey protein concentrate contains proteins which are present in an essentially undenatured state and wherein the biological activity of the whey protein concentrate is dependent on the overall amino acid and small peptides pattern resulting from the contribution of all its protein components and a method of producing said whey protein composition. The invention also relates to several applications of said composition.Type: GrantFiled: October 4, 1989Date of Patent: March 1, 1994Assignee: Immunotec Research Corporation, Ltd.Inventors: Gustavo Bounous, Phil Gold, Patricia A. L. Kongshavn
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Patent number: 5256640Abstract: Nutritional supplements and methods of use of the supplements to maximally stimulate gallbladder contraction in patients undergoing rapid weight loss, to prevent the build up of bilary sludge and/or gallstones.Type: GrantFiled: September 30, 1991Date of Patent: October 26, 1993Assignee: Sandoz Ltd.Inventors: Francis J. Peterson, Louis J. Arrone
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Patent number: 5254551Abstract: A flour fortification formulation comprises riboflavin in an amount of 0.5 to 10 weight percent. The riboflavin is in the form of a riboflavin granulate which exhibits a flowability index of from 75 to 750, an average granule size of from 50 microns to 300 microns. Furthermore, the granules comprise riboflavin in an amount of from 75 weight percent to 99.5 weight percent.Type: GrantFiled: April 30, 1990Date of Patent: October 19, 1993Inventors: Paula S. Kirk, Douglass N. Schmidt
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Patent number: 5238965Abstract: The subject invention relates to methods for regulating wrinkles in mammalian skin comprising topical application of a lysophosphatidic acid compound having the structure: ##STR1## or a cyclic derivative thereof having the structure: ##STR2## or a pharmaceutically acceptable salt thereof, wherein --R is unsubstituted or substituted, saturated or unsaturated, straight or branched chain alkyl having from 12 to about 23 carbon atoms; each --X-- is independently --O-- or --S--; and --Y-- is --O-- or --CH.sub.2 --.Type: GrantFiled: May 31, 1991Date of Patent: August 24, 1993Assignee: The Procter & Gamble CompanyInventors: Gary A. Piazza, Adam W. Mazur
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Patent number: 5236920Abstract: A free-flowing granulated riboflavin product has granules comprised of from about 75 to about 99.5 weight percent riboflavin. The riboflavin product exhibits a flowability index of from about 75 to about 750.Type: GrantFiled: September 18, 1992Date of Patent: August 17, 1993Assignee: Basf CorporationInventors: Terence K. Kilbride, Jr., Rudolph E. Lisa, Walter J. Tuman
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Patent number: 5229104Abstract: The present invention relates to oil-in-water emulsion compositions useful for imparting an artificial tan to human skin. These emulsions contain paucilamellar lipid vesicles, i.e. vesicles comprising several concentric lipid bilayers, encapsulating an aqueous dihydroxyacetone solution. The vesicles comprise a polyoxyalkylene alkyl ether, a sterol, a quaternary ammonium compound, and optionally, a non-surface active oil. In further embodiments, these emulsion compositions contain one or more sunscreens, and are also useful for protecting human skin from the harmful effects of sunlight and other sources of ultraviolet radiation. The present invention also relates to methods for preparing these compositions, methods for providing an artificial tan to human skin, and methods for protecting human skin from the harmful effects of ultraviolet radiation.Type: GrantFiled: April 29, 1991Date of Patent: July 20, 1993Assignee: Richardson-Vicks Inc.Inventors: John P. Sottery, George E. Deckner
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Patent number: 5223264Abstract: The present invention relates to oral effervescent dosage forms for the administrations of an intended ingredient to children, and processes for their administration.Type: GrantFiled: August 26, 1991Date of Patent: June 29, 1993Assignee: Cima Labs, Inc.Inventors: Fred Wehling, Steve Schuehle, Navayanarao Madamala
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Patent number: 5219568Abstract: A pharmaceutical composition for the treatment of hoarseness. The composition is administered orally in unit dosage form. It is based on the combination of Varidase (a combination of streptokinase and streptodornase), an antiinflammatory corticosteroid, an antihistamine and an expectorant. The composition may optionally contain vitamins, like vitamin B.sub.1 or Vitamin B.sub.2. The invention further relates to a method for the treatment of hoarseness in humans, which comprises administering an effective quantity of a composition as defined above.Type: GrantFiled: April 6, 1990Date of Patent: June 15, 1993Inventor: Israel Nageris
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Patent number: 5214042Abstract: The present invention encompasses methods of using 5-phenyl-2-furan esters, amides and ketones and compositions thereof to prevent or limit neuronal death or degeneration in a human or lower animal. These methods comprise systemically administering to such human or other animal a safe and effective amount of a compound of the formula: ##STR1## wherein (1) X is halo or hydrogen, and Y is a substituent selected from the group consisting of unsubstituted or halogen-substituted methyl, halo, nitro, amino, and methoxy; and(2) R is R.sup.1 C(0)OH, R.sup.1 C(0)N(R.sup.3).sub.2, N(R.sup.3).sub.2, OR.sup.1 N(R.sup.3).sub.2, R.sup.1 N(R.sup.3).sub.2, N(R.sup.2)R.sup.1 N(R.sup.3).sub.2, or N(R.sup.2)N(R.sup.3).sub.2 ; whereR.sup.1 is C.sub.1 -C.sub.3 alkyl which is unsubstituted or substituted with C.sub.1 -C.sub.2 alkyl;R.sup.2 is hydrogen or lower alkyl; andeach R.sup.3 is, independently, hydrogen or lower alkyl; orboth R.sup.Type: GrantFiled: March 18, 1992Date of Patent: May 25, 1993Assignee: Norwich Eaton Pharmaceuticals, Inc.Inventor: Eugene G. Drust
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Patent number: 5207998Abstract: Disclosed are sunscare compositions having enhanced substantivity, efficacy and the like for protecting the skin from the harmful effects of ultraviolet irradiation, such as sunburn and sun-induced premature aging of the skin.Type: GrantFiled: May 7, 1991Date of Patent: May 4, 1993Assignee: Richardson-Vicks Inc.Inventors: Larry R. Robinson, Marie A. Rinaldi, Anil J. Gupte
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Patent number: 5198216Abstract: A composition for enhancing the performance of animals, such as horses or dogs, is composed of adrenal and pituitary raw tissue concentrates, vitamin C, bioflavonoid complex, pantothenic acid, methionine, choline, vitamin B1, vitamin B2, vitamin B6, niacinamide, magnesium, vitamin B12, folic acid and organic iodine. The composition is adapted to be orally administered to an animal, is composed of all natural substances, and the relative proportions of the components are approximately:at least 40 parts adrenal raw tissue concentrate toat least 2 parts pituitary raw tissue concentrate to30-60 parts vitamin C to20-30 parts magnesium to10-20 parts of each of pantothenic acid, methionine and choline to8-15 parts of each of niacinamide and bioflavonoid complex to1-5 parts of each of vitamins B1, B2 and B6 to0.1-1 parts organic iodine to0.05-0.5 parts folic acid.Type: GrantFiled: July 30, 1990Date of Patent: March 30, 1993Assignee: Daliff CorporationInventor: David M. McGee
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Patent number: 5185336Abstract: A process for the production of free-flowing, directly compressible, at least 99.5% by weight pure vitamin B.sub.1, vitamin B.sub.2, vitamin B.sub.6, vitamin C, sodium ascorbate or calcium ascorbate comprises spray drying a 5 to 25% aqueous solution or suspension of the corresponding vitamin or sodium or calcium ascorbate. The products of this process as well as tablets and other solid dosage forms, which can be formed from these products, are also described.Type: GrantFiled: January 21, 1992Date of Patent: February 9, 1993Assignee: Hoffmann-La Roche Inc.Inventors: Gerold Caviezel, Frank Mertin, Jean-Claude Tritsch
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Patent number: 5156852Abstract: In accordance with the present invention, a composition is provided with Vitamins C and E, zinc acetate, copper, selenium, manganese, and at least one of L-cysteine, pyridoxine, and riboflavin. The Vitamins C and E serve as antioxidants, while the zinc acetate, copper, selenium and manganese serve as cofactors for metalloenzymes which scavenge oxidizers. The remaining three compounds tend to enhance glutathione concentration. All the elements are provided in a tablet or caplet form which is suitable for oral ingestion. Preferably, the composition is taken periodically each day of a treatment period.Type: GrantFiled: September 18, 1991Date of Patent: October 20, 1992Assignee: La Haye Laboratories, Inc.Inventors: Peter G. La Haye, Randall J. Olson
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Patent number: RE36288Abstract: The present invention provides a method for providing nutrition to elderly patients. Pursuant to the present invention, the enteral composition includes a protein source, a lipid source, and a carbohydrate source. Preferably, the protein source includes at least 18% of the total calories. In an embodiment, the carbohydrate source includes a source of dietary fiber including a balance of soluble to insoluble fiber ratio of approximately 1:3. Still further, the composition of the present invention also includes increased levels of certain vitamins and minerals.Type: GrantFiled: July 9, 1998Date of Patent: August 31, 1999Assignee: Nestec Ltd.Inventors: Paul M. Lin, Shen-Youn Chang, Chris Kruzel