Abstract: This invention relates to alkanoic acid compounds having phenyl and heteroarylthio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

Abstract: In accordance with the present invention, a composition is provided with Vitamins C and E, zinc, copper, selenium, manganese, and at least one of L-cysteine, pyridoxine, and riboflavin. The Vitamins C and E serve as antioxidants, while the zinc, copper, selenium and manganese serve as cofactors for metalloenzymes which scavenge oxidizers. The remaining three elements tend to enhance glutathione concentration. All the elements are provided in a tablet or caplet form which is suitable for oral ingestion. Preferably, the composition is taken periodically each day of a treatment period.

Abstract: A composition which consists of a compound belonging to the Vitamin B group and having a solubility in water at 20.degree. C. of not more than 5%, and mannitol, is stable in itself and undergoes less influence under ambient humidity conditions.Its good flowability is retained during storage, only with very small changes, if any.

Abstract: A novel method for enhancing the fertility and/or prolificacy of non-ruminant animals is provided. Riboflavin is administered in enhanced levels during gestation and, particularly, during a critical phase of gestation. The beneficial effects are achieved by elevating the concentration of riboflavin in the uterine fluids which surround the developing embryo.

Abstract: Therapeutic formulations containing liquid bee honey for the treatment of vitamin deficiency and as a cough supressant. The disclosure is also directed to a preferred embodiment for the formulation of therapeutic formulations containing liquid bee honey.

Abstract: The invention involves a riboflavin composition comprising about 70% to about 90% by weight riboflavin and about 10% to about 30% by weight of a bulking agent selected from the group consisting of yeast, mold, fungi, bacteria and a mixture thereof, and having a bulk density greater than a riboflavin product having a purity of at least about 90% by weight. The riboflavin composition has improved flowability and reduced electrostatic charge relative to riboflavin products having a purity of at least about 90% by weight. The invention also involves a method for producing the riboflavin composition. The method comprises the steps of mixing riboflavin having a purity of at least about 90% by weight, a volatile, non-toxic liquid, and the bulking agent to produce a blend, and drying the blend.

Abstract: A method for producing a granulated riboflavin product comprises making a specific mixture of riboflavin, binder and water, followed by homogenizing the mixture and thereafter spray-drying the homogenized mixture so that granules are produced. The mixture has a relatively high vitamin and binder content but is reduced to a relatively low viscosity (via homogenization) so that spray drying can be performed.

Abstract: A riboflavin granulate containing from 75 to 99.5 weight percent riboflavin is produced by:A. placing a desired quantity of riboflavin powder in the bowl of a rotary fluid bed granulator;B. fluidizing the powder with fluidizing air while rotating the rotor disc, whereby a fluidized cloud of riboflavin powder is produced; andC. spraying a binder solution into the fluidized cloud;so that at least 90 weight percent of the riboflavin powder combines to form granules.

Abstract: A food supplement which comprises in combination: (i) as an essential active antioxidant ingredient, a material characterized by stability for an extended period of time, at least in the dry state, under ambient conditions and which is selected from the group consisting of water soluble extracts prepared from plant tissue and fractions separable from such extracts by chromatography, and (ii) an orally ingestible diluent or carrier.

Abstract: A vitamin-containing granule comprising one or more compounds selected from the group consisting of vitamin B.sub.6, vitamin B.sub.2, nicotinamide and a pantothenic acid salt, and a binding agent, said compound or compounds accounting for 90 to 99 weight percent of the granules on the dry basis, can be prepared by spray-coating the powders of said compound or compounds with a solution containing a binder while maintaining the powders in a fluidized state in a fluidized-bed granulation apparatus.The granules are highly flowable and blend well with other medicaments, granules, additives, and so on. In addition to this, the granules are excellent in compressibility so that they can be processed into tablets with small amounts of excipients, and the tablets therefrom have satisfactory high hardness.

Abstract: A pharmaceutical composition is described, which contains a fraction consisting of low molecular proteins and/or oligo peptides, and a yellow fraction containing riboflavine, which is associated with organ specific oligo peptides, which fractions are obtainable by fractionation of thymus extract. This composition has a significant immuno stimulating activity, and can be used for the treatment of immuno deficiency diseases, as for example, for T-cell-deficiencies.

Abstract: The present invention relates to new carbazates of the general formula (I), ##STR1## wherein A is C.sub.3-10 alkyl, C.sub.3-10 alkenyl, C.sub.2-10 haloalkyl, trifluoromethyl, phenyl-C.sub.1-3 alkyl, phenyl-C.sub.2-3 -alkenyl, naphthyl-C.sub.1-3 alkyl; phenyl optionally substituted by one or more identical or different substituent(s) selected from C.sub.1-4 alkyl, halogen, C.sub.1-4 alkoxy and hydroxy; C.sub.3-7 cycloalkyl-C.sub.1-3 alkyl; optionally nitro-substituted furyl; diphenyl-hydroxy-methyl or indazolyl optionally substituted by one or more C.sub.1-4 alkoxy group(s) andR represents C.sub.1-4 alkyl,with the proviso that if R stands for ethyl, A is other than tertiary butyl, and acid addition salts thereof, a process for the preparation thereof and feed-additives comprising the same.The compounds of the general formula (I) may be used in animal husbandry due to their weight-gain increasing and fodder utilization improving effect.

Abstract: An improved health food composition comprises; B complex vitamins; a prostaglandin E-1 precursor; a primary emulsifying agent; a flavoring agent; and a preservative. The B complex vitamins include: vitamin B1 (thiamine hydrochloride); vitamin B2 (riboflavin); pantothenic acid; vitamin B6 (pyridoxine hydrochloride); and vitamin B12 (cyanocobalamin). The prostaglandin E-1 precursor may be safflower oil. The primary emulsifying agent is selected from the group consisting of: Poly Sorbate-80; acacia; sodium alginate; carbomer (carboxypolymethylene); carboxymethylcellulose; and others. The flavoring agent is selected from the group consisting of: orange; lemon; and peppermint. The preservative is selected from the group consisting of: sodium benzoate; alcohol; ethyl paraben; ethyl vanillin; glycerin; and others. The improved health fod composition may further comprise a secondary emulsifying agent being selected from the group consisting of: hydroxyethyl cellulose; hydroxypropyl cellulose; and tragacanth.

Abstract: Disclosed are aqueous multivitamin/trace elements formulations stabilized by a water soluble, organic acid that contains carbon-to-carbon unsaturation and water soluble salts thereof selected from the group consisting of maleic acid, fumaric acid, maleamic acid and acrylic acid.

Abstract: The production of urine can be stimulated by a composition wherein a single dose comprises the following: 5 grams calcium ascorbate (ascorbic acid), 1,000 I.U. Vitamin E (d alpha tocopherol acetate), 1 gram pantothenic acid (calcium d-Pantothenate), 100 mg Vitamin B.sub.2 (riboflavin), 100 mg Vitamin B.sub.6 (pyridoxine hydrochloride), 25 mg Vitamin B.sub.1 (thiamine), 2 grams potassium gluconate, a binder.

Abstract: Infant foods suitable for use in the feeding of low birthweight infants, more especially preterm infants, are disclosed. The foods contain a relatively high level of vitamin B.sub.2 and may be prepared so as to have an opacity greater than that of human breast milk leading to less susceptibility of the vitamin B.sub.2 to breakdown by UV-light when used for the feeding of low birthweight infants who are receiving phototherapy. Preferred infant foods according to the invention also have high contents of vitamin B.sub.6, vitamin C, vitamin D, vitamin E, folic acid, copper and zinc while containing no added iron. Another aspect of the invention is the inclusion of taurine and carnitine. One unexpected property of the infant foods according to the invention with high vitamin content is that their use has been found to reduce the incidence of hyperbilirubinaemia in low birthweight infants.

Abstract: Skin care composition containing mineral salts releasing sodium, potassium, megnesium, calcium and zinc salts in defined concentration, and, optionally, compounds releasing copper, manganese, vanadium, aluminum, cobalt and/or iron ions.

Abstract: Disclosed are aqueous multivitamin/trace elements formulations stabilized by a water soluble, organic acid that contains carbon-to-carbon unsaturation and water soluble salts thereof selected from the group consisting of maleic acid, fumaric acid, maleamic acid and acrylic acid.

Abstract: A bath preparations comprise a cyclodextrin clathrate compound of vitamin, saccharifying enzyme and other materials of baths. The vitamin may be selected from the group consisting of vitamin A, vitamin B, vitamin C, Vitamin D, vitamin E, vitamin F and vitamin P. The saccharifying enzyme may be mixed with the cyclodextrin clathrate compound of the vitamin or may be insulated from the cyclodextrin clathrate compound of the vitamin.Method for producing bath preparations comprises contacting vitamin with cyclodextrin to form a cyclodextrin clathrate compound of the vitamin and mixing the cyclodextrin clathrate compound of the vitamin with saccharifying enzyme and other raw materials of baths.

Abstract: A bath preparations comprise a cyclodextrin clathrate compound of a component of milk. The bath preparations may further comprise egg white and/or at least one vitamin selected from the goup consisting of vitamin A, vitamins B, vitamin C, Vitamin D, vitamin E, vitamin F and vitamin P. The bath preparations may be used together with a saccharifying enzyme, which is mixed with the bath preparations or which is insulated from the bath preparations.A method for producing the bath preparations comprises contacting milk, which is selected from the group consisting of cow's milk, components of cow's milk, powdered milk, evaporated milk, components of evaporated milk, raw cream and components of raw cream, with cyclodextrin to form a cyclodextrin clathrate compound of the component of milk, and mixing the cyclodextrin clathrate compound of the component of milk with other raw materials of baths.

Abstract: Flavored, effervescent, water soluble compositions containing water-soluble and oil-soluble vitamins and amino acid chelated minerals in bioavailable form are contained in a composition consisting of 20-30% of a vitamin blend consisting of water-soluble and oil-soluble vitamins adsorbed on a lactose carrier containing a minor amount of propylene glycol, 5-25% of one or more amino acid chelated minerals selected from the group consisting of calcium, magnesium, iron, zinc, copper and manganese, 20-45% citric acid, 5-25% of one or more alkali or alkaline earth metal bicarbonates or carbonates, 1-5% flavoring agent, 0.5-2% of a sweetening agent and sufficient additional lactose carrier to provide the desired vitamin and mineral content per unit dosage which will normally vary between about 2 and 6 grams. When dissolved in water a flavored, lightly carbonated drink is provided which will contain in soluble bioavailable form between about 50 to 100% of the U.S.

Abstract: There is disclosed a method for treatment of food allergies by desensitizing the gastrointestinal tract comprising the oral ingestion of a chemical composition wherein the composition comprises butyric acid or a salt thereof. It further may comprise B.sub.2 vitamin riboflavin, ethyl cellulose as a time release preparation, and salts of capric, caproic and caprylic acids.

Abstract: A composition adapted to prolong the residence time of sulfa and cinchona alkaloid drugs in the circulating plasma of mammals including humans comprising hexanoic acid, potassium hydrogen tartrate, tannic acid, pectin and riboflavin, with the further presence of glutamic acid in the case of sulfa drugs and L-tyrosine in the case of the cinchona alkaloids.

Abstract: A composition adapted to prolong the residence time of sulfa and cinchona alkaloid drugs in the circulating plasma of mammals including humans comprising hexanoic acid, potassium hydrogen tartrate, tannic acid, pectin and riboflavin, with the further presence of glutamic acid in the case of sulfa drugs and L-tyrosine in the case of the cinchona alkaloids.

Abstract: A method for reducing body fat deposition in non-mammals such as chickens by orally administering over a prolonged period a therapeutic mixture of effective amounts of pyruvate and dihydroxyacetone to which may be added riboflavin. The method also increases the total body protein of the non-mammal.

Abstract: A medicament adsorbate containing a magnesium trisilicate having a surface area of at least 400 m.sup.2 /g and having a flake-like structure with multiple interstitial spaces, and having adsorbed therein from about 1% to about 20% by weight of the adsorbate of a medicament drug, wherein the medicament drug is a nutritional supplement or laxative.

Abstract: The invention refers to a new utilization of a unique vitamin or a combination of various vitamins in the long-term treatment and/or prevention of rheumatic diseases.During a long-term treatment and/or prevention of rheumatic diseases, a unique vitamin or a combination of various vitamins is administered to a patient.

Abstract: A composition for topical application to the skin contains, as a fatty product to provide a nongreasy protective and emollient film thereon, a polyether oligomer having the formula ##STR1## wherein R is alkyl having 1-12 carbon atoms; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen or alkyl having 1-6 carbon atoms, with at least two of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 being hydrogen; m is 1-4; n has an average value equal to or greater than 2; and the number of carbon atoms in each repetitive unit being at least 4.

Abstract: A method for reducing the weight gain in mammals by orally administering over a prolonged period therapeutically effective amounts of pyruvate to which may be added riboflavin. The method also has the effect of increasing the body protein concentration.

Abstract: A method for the preparation of light-stable water-soluble complexes of antitumor antibiotics and binding protein and the resulting products. The antibiotics are of the anthracycline and anthraquinone classes, as defined. The binding protein is purified apo riboflavin binding protein from eggs. The complexes are prepared by admixing solutions of the antibiotic and protein in substantially equimolar proportions. The complexes are useful for preparing stable aqueous solutions of the antibiotics for oral delivery and for redox titrations of anthracyclines.

Abstract: A method for administering vitamins to an air-breathing animal consists of introducing the vitaminic aerosol containing a breath freshener into the nose or mouth opening of the animal.

Abstract: Seizures are inhibited or prevented and tranquilizing effect induced by administering riboflavin or a riboflavin analog, alone or in combination with a conventional anticonvulsant or tranquilizer to enhance its effect.