Abstract: There are disclosed novel oxopyrimidine derivatives of the general formula ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different and are each hydrogen or lower alkyl optionally substituted by lower alkoxy, and R.sub.3 and R.sub.4 may be the same or different and are each phenyl optionally substituted by lower alkyl or halogen, provided that when R.sub.1 and R.sub.2 are both hydrogen, R.sub.3 and R.sub.4 are each substituted phenyl. Pharmaceutical compositions containing these compounds and their use as anticonvulsant, antianxiety and muscle relaxant agents are described.

Abstract: Improved topical pharmaceutical compositions containing a pharmaceutically-active agent and the penetration enhancing agent 1-dodecylazacycloheptan-2-one are disclosed. This agent is used at selected levels in combination with certain C.sub.3 -C.sub.4 diols or a 1-substituted azacycloalkyl-2-one. This composition provides marked transepidermal and percutaneous delivery of the selected pharmaceutically-active agent. A method of treating certain pathologies and conditions responsive to the selected active, systemically or locally, is also disclosed.

Abstract: Disclosed herein are a novel compound, 5-methylthiopyrimidine derivative, notably that represented by the following general formula: ##STR1## wherein X means an oxygen or sulfur atom and R.sup.2 denotes a methyl, allyl or propargyl group, its preparation process and an agricultural and horticultural fungicide containing same as an active ingredient. The above compound exhibits outstanding control effects against plant diseases, especially, late blight of potatoes and the like and downly mildew. It permits preparation of an ideal agricultural and horticultural fungicide owing to its very low toxicity against mammal and fish and its no phytotoxicity.

Abstract: Novel compounds of the formula: ##STR1## wherein R.sup.1 is lower alkyl; R.sup.2 is hydrogen or lower alkyl, which are produced by reacting a compound of the formula: ##STR2## wherein R.sup.3 is hydrocarbon residue, with a compound of the formula: ##STR3## The novel compounds have antiviral and antibacterial activity, and are useful to prolong the life span of tumor-bearing warm-blooded animals.