The Hetero Ring Has 20 Or More Ring Carbons (e.g., Nystatin, Etc.) Patents (Class 514/31)
  • Patent number: 10596165
    Abstract: The present invention provides methods and pharmaceutical compositions for the treatment or prevention of autophagy-related diseases, disorders, or conditions.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: March 24, 2020
    Assignee: RESTORBIO, INC.
    Inventors: Joan Mannick, Chen Schor, Grace Teo
  • Patent number: 10130707
    Abstract: The invention provides liquid or semi-solid pharmaceutical compositions for topical administration comprising a semifluorinated alkane. The compositions are useful for the delivery of active ingredients into the deep layers of the skin or skin appendages. Various active ingredients may be incorporated, such as immunosuppressants, antiinfectives, antifungal agents, antiinflammatory agents, and retinoids.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: November 20, 2018
    Assignee: NOVALIQ GMBH
    Inventors: Bernhard Gunther, Bastian Theisinger, Sonja Theisinger, Dieter Scherer
  • Patent number: 9901569
    Abstract: Compositions and methods for inhibiting Leishmaniasis using AIs are provided. Aspects provide compositions and methods for administering AIs alone or in combination with other compounds to infected hosts.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: February 27, 2018
    Assignee: OHIO STATE INNOVATION FOUNDATION
    Inventors: Kristy Ainslie, Eric Bachelder, Shalini Gautam, Kevin Peine, Abhay Satoskar
  • Patent number: 9872849
    Abstract: In a screening program, the Antarctic sponge Dendrilla membranosa was found to produce diterpenoid secondary metabolites with activity against the leishmaniasis-causing parasite Leishmania donovani. The present invention concerns compositions useful for control of Leishmania spp. parasites in vitro and in vivo and treatment of leishmaniasis; methods for treatment of leishmaniasis; and methods for controlling Leishmania spp. parasites in vitro and in vivo.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: January 23, 2018
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Bill J. Baker, Christopher G. Witowski, John Alan Maschek, Brian Vesely, Dennis E. Kyle
  • Patent number: 9801895
    Abstract: The cream formulation of the present invention is a topical cream made with antimycotic (amphotericin B) and a mixture of excipients where the water present in the formulation smoothes inflamed tissue. The cream has a particular application for the treatment of cutaneous leishmaniasis and mucosal leishmaniasis in humans and animals. The topical application avoids the risks of toxicity and the gastrointestinal hassles of pills treatments. It has greater acceptability from patient and does not require of valuations before, during or after treatment to check toxicity levels of the liver, kidney and heart.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: October 31, 2017
    Assignees: HUMAX PHARMACEUTICAL S.A., UNIVERSIDAD DE ANTIOQUIA
    Inventors: Ivan Dario Velez-Bernal, Sara Maria Robledo-Restrepo, Martha Beatriz Robledo-Restrepo, Alba Lucia Ceballos-Maya, Newar Andres Giraldo-Alzate, Alvaro Gomez-Zuluaga, Juan Jose Zuluaga-Rivera
  • Patent number: 9642826
    Abstract: An emulsion is provided including: an oil component and a water component, the oil component including: fish oil triglycerides in an amount of about 60% to about 90% based on the weight of the oil component; wherein the fish oil triglycerides include omega-3 fatty acids, expressed as triglycerides, in an amount of at least 60%, based on the total weight of the fatty acids of the fish oil triglycerides; wherein the fish oil triglycerides include a total amount of EPA and DHA, expressed as triglycerides, of at least 45%, based on the total weight of the fatty acids of the fish oil triglycerides; and, at least one medium-chain triglyceride, wherein a total amount of the at least one medium-chain triglyceride is from about 10% to about 40% based on the weight of the oil component.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: May 9, 2017
    Assignee: STABLE SOLUTIONS LLC
    Inventor: David F. Driscoll
  • Patent number: 9605015
    Abstract: The present invention relates to a novel polyene compound similar to nystatin, a method for preparing the same, and an antifungal drug comprising the novel polyene compound as an active ingredient. Compared to nystatin comprising one sugar, NNP, which is the polyene compound similar to nystatin, displays 300 times higher solubility and ten times lower cytotoxicity while maintaining antifungal activity, and thus can be useful in developing a novel polyene antifungal agent having improved solubility and less toxicity in terms of pharmacokinetics.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: March 28, 2017
    Assignee: INHA-INDUSTRY PARTNERSHIP INSTITUTE
    Inventors: Eung-Soo Kim, Kyu Boem Han, Shuangjun Lin, Dekun Kong, Linquan Bai, Zixin Deng, David H. Sherman, Mi-Jin Lee
  • Patent number: 9487787
    Abstract: Methods and compositions for the rapid and reversible destabilizing of specific proteins using cell-permeable, synthetic molecules are described. Stability-affecting proteins, e.g., derived from FKBP and DHFR proteins are fused to a protein of interest and the presence or absence of the ligand is used to modulate the stability of the fusion protein.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: November 8, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Thomas J. Wandless, Laura Anne Banaszynski, Mari Iwamoto, Lystranne Alysia Maynard, Ling-Chun Chen
  • Patent number: 9096633
    Abstract: Stable needle shaped crystals of natamycin having a mean length of between 0.1 and 20 ?m.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: August 4, 2015
    Assignee: DSM IP ASSETS B.V.
    Inventors: Ben Rudolf de Haan, Ferdinand Theodorus Jozef van Rijn
  • Patent number: 9090541
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: July 28, 2015
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Peter Viski, Beena Bhatia, Tadeusz Warchol, David Messersmith
  • Publication number: 20150147382
    Abstract: A topical liposomal composition of Amphotricin B (AmB) and method for preparing same, which can be used as a composition and method for preparing topical liposomal compositions of other hydrophobic drugs. The formulation using AmphotricinB can be used for treating fungal or protozoan infections. The composition is stable with no significant changes in the sizes and AmB content of liposomes after storing at 4° C. and room temperature (22° C.) for more than 20 months. In in vivo and in vitro testing, the compositions exhibit high efficacy in treating cutaneous leishmaniasis.
    Type: Application
    Filed: September 19, 2014
    Publication date: May 28, 2015
    Applicant: Exir Nano Sina Company
    Inventors: Mahmoud Reza Jaafari, Ali Khamesipour
  • Publication number: 20150150159
    Abstract: The present invention relates to new antifungal compositions and their use in the method for controlling fungal diseases in mushrooms.
    Type: Application
    Filed: July 16, 2013
    Publication date: May 28, 2015
    Inventor: Jacobus Stark
  • Publication number: 20150147380
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Application
    Filed: January 29, 2015
    Publication date: May 28, 2015
    Inventors: RAPHAEL MANNINO, RUYING LU
  • Publication number: 20150140074
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Application
    Filed: January 29, 2015
    Publication date: May 21, 2015
    Inventors: RAPHAEL MANNINO, RUYING LU
  • Publication number: 20150141248
    Abstract: The present invention relates to new antifungal compositions and their use in the treatment of agricultural products.
    Type: Application
    Filed: January 30, 2015
    Publication date: May 21, 2015
    Inventors: Jacobus Stark, Angelique De Rijk
  • Publication number: 20150133297
    Abstract: The present invention relates to new antifungal compositions and their use in the treatment of agricultural products.
    Type: Application
    Filed: April 25, 2013
    Publication date: May 14, 2015
    Inventors: Jacobus Stark, Eva Louise Wilhelmine Sack
  • Publication number: 20150126467
    Abstract: The disclosure relates to use of alginate oligomers to enhance the effects of antifungal agents. The invention provides a method to improve the efficacy of an antifungal agent against a fungus, said method comprising using said antifungal agent together with an alginate oligomer. The fungus may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antifungal agent in treating a subject infected, suspected to be infected, or at risk of infection, with a fungus. In another aspect the method can be used to combat fungal contamination of a site e.g., for disinfection and cleaning purposes.
    Type: Application
    Filed: September 14, 2012
    Publication date: May 7, 2015
    Applicant: AlgiIPharma AS
    Inventors: Edvar Onsøyen, Arne Dessen, David William Thomas, Katja Etel Hill, Hàvard Sletta, Anne Tøndervik, Geir Klinkenberg, Rolf Myrvold
  • Publication number: 20150126436
    Abstract: The present invention provides a method of treatment of Scedosporium spp.
    Type: Application
    Filed: May 13, 2013
    Publication date: May 7, 2015
    Applicant: BIODIEM LIMITED
    Inventors: Julie Phillips, Tania Sorrell, Sharon Chen
  • Patent number: 9023790
    Abstract: The present invention relates to aqueous solutions useful as pharmaceutical compositions of posaconazole for intravenous administration. These compositions include a solubilizing agent, such as a modified ?-cyclodextrin in an acidified solution, which can also include a chelating agent such as disodium edetate (EDTA). In clinical trials, a 200 mg posaconazole dose of the selected composition was found to achieve acceptable pharmacokinetic properties.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: May 5, 2015
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Susan K. Heimbecher, David Monteith, James D. Pipkin
  • Publication number: 20150119349
    Abstract: The present invention relates to new antifungal compositions and their use in the treatment of agricultural products.
    Type: Application
    Filed: April 25, 2013
    Publication date: April 30, 2015
    Inventors: Jacobus Stark, Eva Louise Wilhelmine Sack
  • Patent number: 9018178
    Abstract: The present invention provides an aqueous antifungal composition comprising a polyene antifungal compound and a thickening agent. The composition can be used in the protection against the development of fungi on food, feed and agricultural products.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: April 28, 2015
    Assignee: DSM IP Assets B.V.
    Inventors: Pim Van Hee, Laurentius Cornelis Adrianus Van Santen, John Mark Faragher
  • Patent number: 9017956
    Abstract: Provided herein are uses of genes for HOG, Ras and cAMP signal transduction pathways to treat fungal infection. To regulate the HOG pathway of Cryptococcus neoformans, roles of SSK1, TCO2, SSK2, PBS2, HOG1, ENA1 and NHA1 genes were investigated to find that a biosynthesis level of ergosterol is increased when these genes are inhibited. When the genes are inhibited, a large amount of ergosterol is distributed on a fungal cell membrane. Accordingly, since there are many working points of an ergosterol-binding antifungal agent, an efficiency of the ergosterol-binding antifungal agent can be considerably improved. To regulate the Ras and cAMP pathways of Cryptococcus neoformans, roles of RAS1, RAS2, CDC24, GPA1, CAC1, ACA1, PKA1, HSP12 and HSP122 genes were investigated to find that a sensitivity to a polyene- or azole-based drug is increased when these genes are inhibited.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: April 28, 2015
    Assignee: Nutrex Technology Co., Ltd.
    Inventors: Yong-Sun Bahn, Young-Joon Ko, Shin-Ae Maeng, Kwang Woo Jung, Gyu Bum Kim
  • Publication number: 20150111730
    Abstract: A pesticidal composition comprises a compound of formula I or any agriculturally acceptable salt thereof, wherein R1, R2, R4, R5, R6, R7, Z, Q, and Y are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests, or to an area to control pests.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: Noormohamed M. Niyaz, Ann M. Buysse, David A. Demeter, Negar Garizi, Ricky Hunter, Daniel Knueppel, Paul R. LePlae, Christian T. Lowe, Akshay Patny, Tony K. Trullinger, Martin J. Walsh, Yu Zhang
  • Patent number: 8993603
    Abstract: A pharmaceutical composition containing one or more antifungal agents selected from an arylamidine derivative represented by the general formula: (wherein R1 represents an amidino group that may be substituted with a hydroxyl group that may be protected with an acyl group, an amidino group that may be substituted with an alkoxy group that may be substituted, or an amidino group that may be substituted with an aralkyloxy group that may be substituted; R2 and R3 identically or differently represent a hydrogen atom or a halogen atom) or a salt thereof, an azole antifungal agent, a polyene antifungal agent, a candin antifungal agent and a fluoropyrimidine antifungal agent has a strong antifungal activity and is useful for the treatment of fungal infection. A method for using them in combination is useful as an excellent therapeutic method for fungal infection.
    Type: Grant
    Filed: April 5, 2006
    Date of Patent: March 31, 2015
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Nobuhiko Nomura, Hiroshi Nishikawa, Noritomo Fujino
  • Patent number: 8980303
    Abstract: The invention relates to medicine and pharmacology, more particularly to a pharmaceutical composition in the form of vaginal suppositories for treating candidal vaginitis and vulvovaginitis, containing antimycotics and prebiotics. The contents of the composition for therapeutic use make it possible to achieve the synergistic effect of stimulating the growth of the normal vaginal microflora through the presence of prebiotics and inhibiting the growth and eliminating pathogenic Candida fungi through the presence of modern antimycotics. Furthermore, the composition substantially contains such antimycotics to which representatives of the normal flora, i.e. lactobacilli and bifidobacteria, are insensitive. The method for treating mycetogenous or bacterial vaginosis, vaginitis and vulvovaginitis is carried out with the aid of the antimycotic and prebiotic pharmaceutical composition in a medicinal form for local application.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: March 17, 2015
    Assignee: Lugs International Ltd.
    Inventors: Aleksander Vladimirovich Dikovskiy, Oleg Valentinovich Dorozhko, Anatolievich Bor Rudoi
  • Publication number: 20150056160
    Abstract: An invention relating to therapeutic pharmacological agents and methods to chemically induce intracellular hyperthermia and/or free radicals for the diagnosis and treatment of infections, malignancy and other medical conditions. The invention relates to a process and composition for the diagnosis or killing of cancer cells and inactivation of susceptible bacterial, parasitic, fungal, and viral pathogens by chemically generating heat, and/or free radicals and/or hyperthermia—inducible immunogenic determinants by using mitochondrial uncoupling agents, especially 2,4 dinitrophenol and, their conjugates, either alone or in combination with other drugs, hormones, cytokines and radiation.
    Type: Application
    Filed: February 24, 2014
    Publication date: February 26, 2015
    Inventors: Nicholas Bachynsky, Woodie Roy
  • Publication number: 20150045316
    Abstract: The invention provides semisynthetic derivatives of Nystatin A1, water soluble salts and complexes, pharmaceutical compositions and plant protection products comprising the derivatives and their use, as antifungal antibiotics (Formula 1a).
    Type: Application
    Filed: March 7, 2013
    Publication date: February 12, 2015
    Applicant: BLIRT S.A.
    Inventors: Edward Borowski, Natalia Salewska, Joanna Borosmajewska, Maria Milewska, Malgorzata Wysocka, Slawomir Milewski, Andrzej Skladanowski, Adam Treder, Ewa Owska, Izabela Lacka
  • Publication number: 20150038442
    Abstract: The invention relates to a composition comprising a polyelectrolyte complex of a polyanion and a polycation, further comprising at least one biocide comprising natamycin and/or phosphite. A preferred composition comprises lignosulfonate and chitosan, preferably in relative amount of from 1:2 to 60:1 (w/w). The invention further relates to methods for generating a composition according to the invention, and to uses of a mixture according to the invention for protecting an agricultural plant or plant part against a pathogen.
    Type: Application
    Filed: March 5, 2013
    Publication date: February 5, 2015
    Inventors: Wilhelmus Maria van der Krieken, Wilhelmus Bernardus Albertus Hendrikus Rutten, Christiaan Gerardus Johannes Maria Jans
  • Publication number: 20150037396
    Abstract: The present application discloses a targeting composition that actively targets chitin-like materials, such as those found in fungi, a drug delivery vehicle comprising a micelle that comprises the targeting composition and one or more anti-fungal drugs, and methods of using the drug delivery vehicle.
    Type: Application
    Filed: August 3, 2013
    Publication date: February 5, 2015
    Inventors: Thomas Meehan, Quyen Ong
  • Publication number: 20150038441
    Abstract: The invention relates to a kit-in-part comprising of a composition for the use as a cleaning and treating of ears of a companion animal and suitable packaging material, wherein the kit-in part additionally consists of components selected from the group of a pharmaceutical composition for use in the treatment of otitis externa, application and dosage information, cannules, cotton swabs, gauzes and information about the cleaning and maintenance ears of a companion animal.
    Type: Application
    Filed: December 21, 2011
    Publication date: February 5, 2015
    Applicant: BOEHRINGER INGELHEIM VETMEDICA GMBH
    Inventors: Joachim Karle, Reinhard Seffner
  • Patent number: 8945061
    Abstract: The present invention relates to a formulation and method for treating an ear infection, especially otomycosis and otitis externa, by administering a one-time only treatment comprising an antibiotic, and antifungal, and an anti-inflammatory in a thick, otic carrier. In one embodiment, the formulation comprises a therapeutically effective amount of active ingredients including a fluoroquinolone, a triazole antifungal, a thiocarbamate antifungal, a corticosteroid and a polyene antifungal, as well as a thickener such that the formulation, upon applying to the infected ear canal, gels and remains in the ear canal, continuously releasing the active ingredients for several days, achieving consistent complete (98-100%) clinical resolution of otomycosis and otitis externa in a single application.
    Type: Grant
    Filed: January 3, 2013
    Date of Patent: February 3, 2015
    Assignee: Entrx LLC
    Inventors: Matthew Branch, Vance Oglesbee
  • Patent number: 8946121
    Abstract: The present invention relates to new antifungal compositions and their use in the treatment of agricultural products.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: February 3, 2015
    Assignee: DSM IP Assets B.V.
    Inventors: Jacobus Stark, Angelique De Rijk
  • Patent number: 8937062
    Abstract: Compositions comprise a fluoroquinolone having Formulae I-VIII for treating, reducing, ameliorating, or preventing infections caused by some bacteria that are resistant to an antibacterial drug. Methods for treating, reducing, ameliorating, or preventing such infections use such compositions.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: January 20, 2015
    Assignee: Bausch & Lomb Incorporated
    Inventors: Praveen Tyle, Pramod Kumar Gupta, Susan E. Norton, Lynne Brunner, Joseph Blondeau
  • Publication number: 20140371134
    Abstract: In one aspect, a dry formulation for the effective administration of multiple medications simultaneously for one or more ailments may be provided. The dry formulations include one or more of the following actives in combination with pharmaceutically acceptable excipients or additives: a) at least one antibiotic; b) at least one anti-inflammatory steroid; and c) at least one antifungal agent.
    Type: Application
    Filed: June 18, 2013
    Publication date: December 18, 2014
    Inventor: Jay Richard Ray, II
  • Publication number: 20140364385
    Abstract: An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
    Type: Application
    Filed: June 9, 2014
    Publication date: December 11, 2014
    Inventors: Timothy BUGNI, Thomas WYCHE, David ANDES, Douglas BRAUN
  • Publication number: 20140363506
    Abstract: Formulations are provided for pulmonary administration of an antifungal agent to a patient. Methods of using the formulations in the treatment of antifungal infections are also provided, including treatment of pulmonary aspergillosis with amphotericin B-containing formulations. Methods of manufacturing the formulations to achieve optimum properties are provided as well.
    Type: Application
    Filed: November 26, 2012
    Publication date: December 11, 2014
    Applicant: NOVARTIS AG
    Inventor: Novartis AG
  • Publication number: 20140356455
    Abstract: Methods of generating cell lines with a sequence variation or copy number variation of a gene of interest, methods of use thereof, and cell lines with a sequence variation or copy number variation of a gene of interest are provided.
    Type: Application
    Filed: December 6, 2013
    Publication date: December 4, 2014
    Applicants: The Board of Trustees of the Leland Stanford Junior University, Parkinson's Institute
    Inventors: Renee Ann Reijo Pera, J. William Langston, Birgitt Schule, Theodore D. Palmer, Blake Byers, Ha Nam Nguyen, James Anthony Byrne, Branden John Cord
  • Publication number: 20140356457
    Abstract: This invention relates to a method of identifying a modulator of an NADPH oxidase, whereby said modulator is suitable as a lead compound and/or as a medicament for the treatment and/or prevention of hearing loss and/or phantom hearing, the method comprising the steps of (a) contacting a test compound with a protein, wherein said protein (i) comprises or consists of the amino acid sequence of any one of SEQ ID NO: 1, 3 or 5, or (ii) is encoded by a nucleic acid comprising or consisting of the sequence of any one of SEQ ID NO: 2, 4, 6, 23 or 24, or (iii) is a fragment of the protein according to (i) or (ii) and exhibits NADPH oxidase activity, or (iv) has a sequence at least 75% identical with the protein according to (i) or (ii) or with the fragment according to (iii) and exhibits NADPH oxidase activity, and optionally with one or more NADPH oxidase subunits, under conditions allowing binding of said test compound to said protein or, if present, said subunit(s); (b) optionally determining whether said test com
    Type: Application
    Filed: April 7, 2014
    Publication date: December 4, 2014
    Applicant: UNIVERSITY OF GENEVA
    Inventors: Karl-Heinz KRAUSE, Botond BANFI
  • Patent number: 8895055
    Abstract: The present invention provides a nanodisc without a membrane scaffold protein. The nanodisc includes a telodendrimer and a lipid; the nanodisc does not include a membrane scaffold protein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Methods of making the nanodiscs are also provided.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: November 25, 2014
    Assignee: The Regents of the University of California
    Inventors: Kit S. Lam, Juntao Luo, Joyce S. Lee
  • Publication number: 20140335152
    Abstract: The present invention relates to a new use of a known medicament. Specifically, the invention relates to methods and compositions for enhancing the therapeutic efficacy of a therapeutic agent by increasing the uptake of the therapeutic agent by target cells, and in particular relates to a pharmaceutical composition comprising a regulating agent of lipid raft/caveolae-dependent endocytic pathway and some therapeutic agents, such as anti-tumor agents. The invention also relates to a method for screening a regulating agent of lipid raft/caveolae-dependent endocytic pathway capable of enhancing the therapeutic efficacy of anti-tumor agents.
    Type: Application
    Filed: March 28, 2012
    Publication date: November 13, 2014
    Applicants: TSINGHUA UNIVERSITY, BEIJING PROTGEN LTD.
    Inventors: Yongzhang LUO, Yang CHEN, Yan FU, Lin JIA, Guodong CHANG
  • Patent number: 8883748
    Abstract: A novel formulation for treating fungal infections comprising Cholesterol containing Nanosomal Amphotericin B in a Saline Suspension.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: November 11, 2014
    Assignee: Lifecare Innovations Pvt. Ltd.
    Inventors: Lily Verma, Jitendra Nath Verma
  • Publication number: 20140328917
    Abstract: An organic compound nano-powder comprising a granular organic compound with an average particle diameter of 500 nm or less and a 90%-diameter of less than 1500 nm and a carbohydrate compound comprising at least any one of a sugar and a sugar alcohol and with amount of 0.3 times or more by mass relative to amount of the organic compound, a method for producing the same, and a suspension having the organic compound dispersed in a liquid dispersion medium in which the organic compound is insoluble or poorly soluble.
    Type: Application
    Filed: May 11, 2013
    Publication date: November 6, 2014
    Inventors: Takahiro Tada, Kazuhiro Kagami, Shiro Yokota
  • Publication number: 20140309108
    Abstract: The present invention relates to novel compositions for treating seeds. Moreover, the present invention is directed to the production of these compositions and the uses of these compositions.
    Type: Application
    Filed: December 21, 2012
    Publication date: October 16, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Frederik Jan Hendrik Schreurs, Jacobus Stark, Angelique De Rijk
  • Publication number: 20140303105
    Abstract: The invention refers to primycin or a primycin component or a combination of primycin components, for use in the treatment or prevention of infections caused by Gram-positive bacteria resistant to methicillin and/or vancomycin and/or mupirocin or by penicillin-resistant streptococci. The invention also covers antibiotic compositions containing these active agents.
    Type: Application
    Filed: October 25, 2012
    Publication date: October 9, 2014
    Applicant: PANNONPHARMA GYÓGYSZERGYÁRTÓ ZRT.
    Inventors: Péter Feiszt, Levente Emödy, József Péter Pallos, Ákos Juhász, Dénes Seffer, Mária Sefferné Szalai, Ágota Pénzes
  • Publication number: 20140296134
    Abstract: Embodiments include methods for generating a metabolite profile of a stool sample and methods of assessing the status of a subject using the metabolic profile derived from a stool sample.
    Type: Application
    Filed: November 8, 2012
    Publication date: October 2, 2014
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Tor Savidge, Sara Dann
  • Publication number: 20140274926
    Abstract: The present invention provides compounds of Formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: IRM LLC
    Inventors: Arnab Kumar CHATTERJEE, Fang LIANG, Casey Jacob Nelson MATHISON, Pranab Kumar MISHRA, Valentina MOLTENI, Advait Suresh NAGLE, Frantisek SUPEK, Liying Jocelyn TAN, Agnes VIDAL
  • Publication number: 20140271923
    Abstract: Patients inflicted with various clustering chronic diseases require treatment with multiple drugs having distinct mechanisms of action. Accordingly, patients with multiple conditions suffer from cumulative side effects of multiple drugs as well as drug-drug interactions. Embodiments, agents, compounds or drugs of the present invention, such as sesquiterpenes, e.g., Zerumbone, replace an equal or larger number of approved drugs during patient treatment. Examples of disorders prevented or ameliorated by administration of the formulations of this invention include but are not limited to inflammatory diseases that may be, oncological, genetic, ischemic, infectious, neurological, hematological, ophthalmological, rheumatoid, orthopedic, neurological, hematological, kidney, vascular, dermatological, gynecological, or obstetric.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 18, 2014
    Inventor: Christopher Brian Reid
  • Publication number: 20140271777
    Abstract: The present invention provides polyphenolic compositions derived from a plant that inhibit the formation of a biofilm. Also provided are combinations that comprise at least one phenolic phytochemical and at least one antimicrobial agent that inhibit the growth of an established biofilm. Further, the present invention provides methods for inhibiting the formation and growth of biofilms.
    Type: Application
    Filed: April 2, 2014
    Publication date: September 18, 2014
    Applicant: BOARD OF TRUSTEES UNIVERSITY OF ARKANSAS
    Inventors: Cassandra L. Quave, Mark S. Smeltzer, Cesar M. Compadre, Howard Hendrickson
  • Publication number: 20140256663
    Abstract: The present invention relates to polyene macrolide derivatives according to the formula: wherein M is a macrocyclic lactone ring; N is a polyene sugar, substituted or unsubstituted; X is independently selected from O, S, N or NH; R is independently selected from an alkyl, cycloalkyl, heterocycloalkyl aryl, heteroaryl, arylalkyl, and heteroaryalkyl group; and i is an integer from 1 to 3, with the condition that it has a negative charge or the zwitterions character is restored; or a pharmaceutically acceptable salt thereof useful as antibiotics.
    Type: Application
    Filed: December 16, 2011
    Publication date: September 11, 2014
    Applicants: CENTRO DE INVESTIGACION Y DE ESTUDIOS AVANZADOS DEL INSTITUTO POLITECNICO AACION, UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO, UNIVERSIDAD AUTONOMA DEL ESTADO DEMORLOS
    Inventors: Armando Antillon Diaz, Maurico Carrillo Tripp, Mario Fernandez Zertuche, Jose David Flores Romero, Fabiola Eloisa Jimenez Montejo, Angel Leon Buitimea, Rosmarbel Morales Nava, Lilia Ocampo Martinez, Ivan Ortega Blake, Jorge Alberto Reyes Esparza, Maria de Lourdes Rodriguez Frangoso, Tania Minerva Santiago Angelino, Maria Cristina Vargas Gonzalez
  • Publication number: 20140242153
    Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
    Type: Application
    Filed: January 30, 2014
    Publication date: August 28, 2014
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Raphael J. Mannino, Susan Gould-Fogerite, Sara L. Krause-Elsmore, David Delmarre, Ruying Lu