Oxygen Of The Saccharide Radical Bonded Directly To A Nonsaccharide Hetero Ring Or A Polycyclo Ring System Which Contains A Nonsaccharide Hetero Ring Patents (Class 514/27)
  • Patent number: 10383842
    Abstract: A method and composition for treating viral infections using a combination of naturally occurring compounds is provided. The method includes administering to a patient at risk of or diagnosed with a viral infection a composition including therapeutically effective amounts of a helicase ATPase inhibitor, a sialidase enzyme inhibitor, and ICAM-1 inhibitor which each also down regulate the immune response. The composition may further include a permeation enhancer.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: August 20, 2019
    Assignee: GLOBAL BIOLIFE INC.
    Inventor: Daryl Thompson
  • Patent number: 10376465
    Abstract: The present invention is directed toward respirable dry powders and particles for systemic delivery of pharmaceutically active agents or delivery to the respiratory tract. The dry powders contain one or more monovalent metal cations (such as Na+), are small and dispersible.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: August 13, 2019
    Assignee: Pulmatrix Operating Company, Inc.
    Inventors: Michael M. Lipp, Jean C. Sung
  • Patent number: 10350230
    Abstract: Disclosed is a use of albiflorin or a pharmaceutically acceptable salt for the prevention and/or treatment of irritable bowel syndrome. The experimental results demonstrate that the prevention, remission and/or treatment of irritable bowel syndrome with albiflorin or a pharmaceutically acceptable salt has significant effects and few side effects. This is a preparation derived from a natural plant for the safe, effective and multi-targeted prevention, remission and/or treatment of irritable bowel syndrome.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: July 16, 2019
    Inventor: Zuoguang Zhang
  • Patent number: 10335356
    Abstract: The present invention discloses a use of neohesperidin or a neohesperidin-containing plant extract in the manufacture of a product for improving and/or promoting skin microcirculation, or for eliminating and/or alleviating diseases or conditions associated with poor skin microcirculation. The present invention also discloses a composition comprising an effective amount of neohesperidin or a neohesperidin-containing plant extract, and to a method for improving and/or promoting skin microcirculation, or eliminating and/or alleviating diseases or conditions associated with poor skin microcirculation, by using neohesperidin. The skin microcirculation of the present invention is preferably eye skin microcirculation.
    Type: Grant
    Filed: November 25, 2011
    Date of Patent: July 2, 2019
    Assignee: Natural Medicine Institute of Zhejiang Yangshengtang Co., Ltd.
    Inventors: Liu Hu, Hongying Lan
  • Patent number: 10328183
    Abstract: Various aspects of the present invention provide compositions and implantable devices including a water-insoluble therapeutic agent solubilized in a matrix of a gallate-containing compound. Other aspects provide methods of manufacturing and using such compositions and devices.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: June 25, 2019
    Assignee: COOK MEDICAL TECHNOLOGIES LLC
    Inventors: John Jackson, Lindsay Stuart Machan, Kevin Letchford
  • Patent number: 10285976
    Abstract: Compositions for treating autoimmune, allergic, or atopic disease comprising a compound that inhibits hyaluronan synthesis and a pharmaceutically acceptable carrier are described. In some embodiments, the compound that inhibits hyaluronan synthesis is 4-methylumbelliferone or a metabolite of 4-methylumbelliferone. Methods for treating autoimmune diabetes, multiple sclerosis and/or autoimmune demyelination, including administering to the subject a composition having a compound in an amount effective to inhibit hyaluronan synthesis in a mammalian subject, are also described.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: May 14, 2019
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON
    Inventors: Paul L. Bollyky, Nadine Nagy, Thomas Wight, Hedwich F. Kuipers
  • Patent number: 10286068
    Abstract: A vaccine composition is disclosed that contains a vaccine antigen and a neutrophil inhibitor in amounts effective to promote an IgA response to the antigen in a subject. Also disclosed is a method for enhancing immune response to a vaccine antigen in a subject that involves co-administering to the subject the vaccine antigen and an adjuvant composition comprising a neutrophil inhibitor in an amount effective to promote an IgA response to the vaccine antigen in the subject.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: May 14, 2019
    Assignee: Ohio State Innovation Foundation
    Inventor: Prosper Boyaka
  • Patent number: 10278949
    Abstract: A biotechnology process that employs membrane technology for obtaining an extract rich in tannins of ellagic acid from blackberries (Rubus spp.) and from other fruits that contain these compounds, as well as to the extract obtained using this method. The method is essentially based on baromembrane technologies that allow mechanical separation and effective fractionation between the polyphenol compounds, by interactions between the physico-chemical properties thereof, the material of the membrane and the molar mass of same, thereby allowing enrichment of a fraction of the natural extract with ellagic acid tannins and modification of the content thereof in terms of anthocyanins and other compounds such as sugars and acids.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: May 7, 2019
    Assignees: UNIVERSIDAD DE COSTA RICA, CENTRO INTERNACIONAL DE COOPERACION EN INVESTIGACION AGRICOLA PARA EL DESARROLLO, CIRAD, CENTRO INTERNACIONAL DE ESTUDIOS SUPERIORES EN CIENCIAS AGRONOMICAS, SUPAGRO
    Inventors: Oscar Gerardo Acosta Montoya, Ana Mercedes Perez Carvajal, Manuel Dornier, Fabrice Vaillant
  • Patent number: 10272099
    Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: April 30, 2019
    Assignees: The Board of Regents of the University of Texas System, The Board of Trustees of the University of Illinois.
    Inventors: Paul J. Hergenrother, David A. Boothman, Joseph S. Bair, Lifen Cao, Jinming Gao, Xiumei Huang, Xiuquan Luo, Xinpeng Ma, Zachary R. Moore, Elizabeth I. Parkinson
  • Patent number: 10196417
    Abstract: A baicalin magnesium compound and methods for preparing and extracting the same. The method for preparing the baicalin magnesium compound includes steps of preparation of a baicalin suspension, preparation of a magnesium ion-containing suspension, reaction and drying. The method for extracting the baicalin magnesium compound includes steps of pretreatment of macroporous resin, extraction, adsorption and elution, concentration and drying and purification. The methods restores the baicalin to the original form as found in radix scutellariae, and the baicalin magnesium compound may be used as a substitute for the baicalin in pharmaceutical applications. As compared to the baicalin, the baicalin magnesium has a greatly increased solubility, faster adsorption rate and higher oral bioavailability. The baicalin magnesium compound may also be easily formulated as a water-soluble injection or a powder injection.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: February 5, 2019
    Assignee: CHENGDE MEDCIAL UNIVERSITY
    Inventors: Cuizhe Liu, Zhixuan Wang, Ceyu Miao, Liyan Liu, Hefei Xue, Xigang Liu, Wenshan Du, Yixin Liu, Lin Zhang, Xiaoxia Mao, Jinjun Liu, Guiqin Zhao
  • Patent number: 10155003
    Abstract: Certain embodiments are directed to methods and compositions for treating obesity, diabetes, and/or cancer with a combination of ursolic acid and resveratrol.
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: December 18, 2018
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Thomas J. Slaga, Jacob Junco, Huiyun Liang, Sara Reyna
  • Patent number: 10149877
    Abstract: The present invention relates to combinations of an agent that stimulates cell proliferation and an anti-inflammatory/analgesic, which are useful in the treatment of peripheral ulcers of various origins, such as radiation dermatitis, diabetic ulcers, ulcers caused by venous stasis of the limbs, bedsores, and the associated skin infections, proctitis, vulvovaginitis and haemorrhoids with vascular lesions. These combinations can be presented as formulations for topical use.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: December 11, 2018
    Assignee: INDENA S.P.A.
    Inventor: Ezio Bombardelli
  • Patent number: 10137136
    Abstract: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: November 27, 2018
    Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. Adams, Steven D. Kunkel, Michael Welsh
  • Patent number: 10131727
    Abstract: The present invention relates to a process for the development of a highly efficient solid state matrix by the activation of acrylate based polymer resin having specialized functional groups with 1,1-Carboxyl diimidazole for immobilizing biologically active macromeloecules such as oxidases, in particular plant oxidases and the most preferred being tea polyphenol oxidase through indirect covalent bonding/cross linking on such activated polymer resin support, are thermally stable, gives very high number of turnovers in vitro (ā€œnā€ times) with tea substrate forming exclusive product Theaflavins without any loss of biological activity and leaving the product remaining in vitro with adherence to matrix rendering the matrix safe towards product poisoning and subsequent partial or complete loss of biological activity of the matrix bound enzyme system and thus well adapted to and well suited biorectors based on such systems.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: November 20, 2018
    Assignee: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
    Inventors: Harsh Pratap Singh, Kapil Sharma
  • Patent number: 10123992
    Abstract: The invention provides compounds, methods, pharmaceutical compositions, and kits for the treatment of proliferative disorders such as cancer. In one aspect, the methods comprise compounds that inhibit the activity of protein kinases, such as cell division cycle (Cdc) kinase. In another aspect, the methods comprise compounds that inhibit Cdc7 and/or Dbf4 activity. In another aspect, the methods comprise compounds that exhibit anti-proliferative properties useful in treating diseases such as cancer. Compounds useful for any of the methods include compounds of the Formula (A) or (B): or pharmaceutically acceptable salts thereof. Exemplary compounds of Formula (A) or (B) include granaticin A, granaticin B, dihydrogranaticin A, dihydrogranaticin B, medermycin, and actinorhodin.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: November 13, 2018
    Assignee: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
    Inventors: Mark G. Frattini, Hakim Djaballah, Thomas J. Kelly
  • Patent number: 10111854
    Abstract: The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: October 30, 2018
    Assignee: The Hong Kong Polytechnic University
    Inventors: Larry Ming-Cheung Chow, Tak Hang William Chan, Kin-Fai Chan, Iris Lai King Wong, Wing-Yiu Kan
  • Patent number: 10098838
    Abstract: The invention relates to water-soluble granules for preparing a drinkable solution, in particular for preventing or treating symptoms associated with mild to moderate chronic venous insufficiency of the lower extremities, containing at least 20 percent by weight of a concentrated extract of red wine leaves, and to a ready-to-use packaging unit comprising one or more portion sachets which contain the granules according to the invention.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: October 16, 2018
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Sandra Sauerland, Sonja Heigenhauser, Uwe Scheuring, Oliver Timm
  • Patent number: 10076513
    Abstract: A pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid), and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a binder, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering an oral pharmaceutical formulation of Compound 1 to the patient.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: September 18, 2018
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Marinus Jacobus Verwijs, Rossitza Gueorguieva Alargova, Ritu Rohit Kaushik, Irina Nikolaevna Kadiyala, Christopher Young
  • Patent number: 10058579
    Abstract: A dietary supplement composition is provided for enhancing the expression of a sirtuin gene or protein. An inventive supplement composition includes at least one cinnamon extract containing at least 0.5% doubly linked Type-A polymers by dry weight. The cinnamon extract is derived from the Cinnamonum aromaticum, Cinnamonum verum or Cinnamonum burmannii plant. In some embodiments, the cinnamon extract is present at approximately 20%-50% of the dry weight of the composition. A vitamin, weight loss agent, or antioxidant is optionally provided in the composition. The dietary supplement composition is administered orally to promote expression or enhanced expression of a sirtuin gene or protein.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: August 28, 2018
    Assignee: IN Ingredients, Inc.
    Inventors: Peter J. Miller, Tim Romero, Bolin Qin, Augustin T. Romero
  • Patent number: 10016421
    Abstract: Disclosed are methods whereby an effective amount of a HDAC6 inhibitor is used to activate a subjects T-cell response to tumor or tumor vaccine. Methods of using HDAC6 inhibitors to increase a subjects anti-tumor immune response, alone or in conjunction with other tumor treatments, are also disclosed.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: July 10, 2018
    Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Eduardo M. Sotomayor, Alejandro V. Villagra
  • Patent number: 9987214
    Abstract: A composition having a pH in the range of from 3 to 8.5, comprising: (a) in the range of from 0.1% to <10% w/w (based on the total weight of the composition) of a stock solution comprising a mixture of bioflavonoids and fruit acids or salts thereof; (b) sodium hyaluronate; and (c) water; and, optionally, (d) a pharmaceutically acceptable carrier therefor; wherein the sodium hyaluronate has an average molecular weight of between 800,000 and 4,000,000.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: June 5, 2018
    Assignees: Oraldent Limited, Ricerfarma S.R.L.
    Inventors: Ian Ripley, Howard Thomas
  • Patent number: 9956242
    Abstract: The pharmaceutical composition of the present invention, which comprises spinosin or a spinosin-containing herbal extract, is a composition for preventing and treating cognitive function disorders, and can effectively improve memory and learning ability, and effectively treat and prevent cognitive function disorders such as dementia and amnesia.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: May 1, 2018
    Assignees: MINISTRY OF FOOD AND DRUG SAFETY, DAE HWA PHARMA, CO., LTD.
    Inventors: Jong Hoon Ryu, Hyung Eun Lee, Sam Sik Kang, Ju Sun Kim, So Young Lee, Do Hoon Kim, Dong Sup Kim, Seung Hee Kim
  • Patent number: 9925152
    Abstract: This disclosure provides generally for antimicrobial compositions and methods of use comprising an anthocyanin, an anthocyanidin or metabolites thereof. Methods for promoting healing of a wound using these compositions are also disclosed. These compositions have broad spectrum antimicrobial activity and are safe for human and animal uses. Further, these compositions are safe for medical uses and industrial uses as antiseptic preparations to reduce or prevent microbial growth.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: March 27, 2018
    Inventor: Lanny Leo Johnson
  • Patent number: 9895390
    Abstract: The technology described herein is directed to the treatment of cancer, e.g. methods and assays relating to selecting and administering a chemotherapy with or without an EZH2 inhibitor.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: February 20, 2018
    Assignee: Children's Medical Center Corporation
    Inventors: Christine M. Fillmore, Carla F. Kim
  • Patent number: 9849151
    Abstract: A Salacia composition described herein significantly reduces appetite, activates Hormone Sensitive Lipase, and manages a healthy lipid profile through inhibition of HMG-CoA Reductase enzyme. Salacia compositions described herein include of at least 12% of polyphenols, 2% of mangiferin and 1% of 25,26-oxidofriedelane-1,3-dione by weight of the composition in the form of extract. The composition is obtained by continuous solvent extraction, employing non-aqueous food grade solvents. Salacia compositions herein reduce appetite by about 18% of routine diet, when effective amounts are administered to a subject in need thereof. Effective management of a healthy lipid profile is thus possible with synergistic combination of reduction in energy intake, activation of Hormone Sensitive Lipase, and inhibition of HMG-CoA Reductase enzyme responsible for cholesterol metabolism.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: December 26, 2017
    Assignee: OmniActive Health Technologies (Canada) Limited
    Inventors: Jayant Deshpande, Khadija Ghanam, Stephen Ewart, Vijaya Juturu
  • Patent number: 9801850
    Abstract: The present invention provides an epigallocatechin gallate derivative (EGCG derivative) that has excellent safety and antibacterial properties. An epigallocatechin gallate derivative represented by the following chemical formula (1), an isomer thereof, or a salt thereof is used as an antibacterial agent. In the formula, R1 to R6 are each a hydrogen atom, halogen, sodium, potassium, or a straight-chain or branched, saturated or unsaturated acyl group and may be identical to or different from one another. The acyl group may be substituted further with one or more substituents. At least one of the R1 to R6 is the acyl group. R7 to R16 are each a hydrogen atom, halogen, sodium, or potassium and may be identical to or different from one another.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: October 31, 2017
    Assignee: OSAKA UNIVERSITY
    Inventors: Kunihiro Kaihatsu, Yoshimi Matsumoto
  • Patent number: 9782386
    Abstract: The invention provides compounds, methods, pharmaceutical compositions, and kits for the treatment of proliferative disorders such as cancer. In one aspect, the methods comprise compounds that inhibit the activity of protein kinases, such as cell division cycle (Cdc) kinase. In another aspect, the methods comprise compounds that inhibit Cdc7 and/or Dbf4 activity. In another aspect, the methods comprise compounds that exhibit anti-proliferative properties useful in treating diseases such as cancer. Compounds useful for any of the methods include compounds of the Formula (A) or (B): or pharmaceutically acceptable salts thereof. Exemplary compounds of Formula (A) or (B) include granaticin A, granaticin B, dihydrogranaticin A, dihydrogranaticin B, medermycin, and actinorhodin.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: October 10, 2017
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Mark G. Frattini, Hakim Djaballah, Thomas J. Kelly
  • Patent number: 9757424
    Abstract: The present invention provides, inter alia, methods for treating or ameliorating the effects of a glioma. Methods of this invention include administering to a subject in need thereof an effective amount of a first active agent, such as e.g., an angiotensin receptor blocker, an antifungal agent, a bisphosphonate, an oxytocin inhibitor, an interleukin-1 (IL-1) inhibitor, a cyclooxygenase inhibitor, an ?2? voltage-dependent calcium channel (VDCC) inhibitor, a dihydroorotate dehydrogenase inhibitor, a calcium channel blocker, a renal sodium-chloride symporter inhibitor, an a2 adrenergic agonist, a phenothiazine antipsychotic, a calcineurin inhibitor, a 5-HT agonist, an angiotensin-converting enzyme (ACE) inhibitor, a direct rennin inhibitor, or combinations thereof, and a second active agent, which is a chemotherapeutic agent. Compositions for treating or ameliorating the effects of a glioma are also provided.
    Type: Grant
    Filed: September 25, 2012
    Date of Patent: September 12, 2017
    Assignee: Biomed Valley Discoveries, Inc.
    Inventors: Reza Halse, Saurabh Saha, Jeffrey James Roix
  • Patent number: 9737515
    Abstract: The present invention relates to compositions and methods for preventing and treating cell proliferation in cancer. More specifically, the present invention relates to compositions and methods for inhibiting tumor growth, and for treating proliferative diseases, particularly colon and breast cancer, with a combined pharmacological approach. Yet more specifically, the compositions for inhibiting tumor growth comprise a combination of: i) a first component which is an ACSL4 inhibitor; and ii) a second component selected from the group consisting of mTOR inhibitor and ER inhibitor.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: August 22, 2017
    Assignee: Consejo Nacional De Investigaciones Cientificas Y Tecnicas (CONICET)
    Inventors: Ernesto Jorge Podesta, Paula Mariana Maloberti, Ulises Daniel Orlando, Melina Andrea Dattilo, Ana Fernanda Castillo, Angela Rosaria Solano
  • Patent number: 9724361
    Abstract: The present invention relates to a pharmaceutical composition for treating liver diseases, containing a narirutin extract of citrus peel extract or narirutin as an active ingredient. The extract or narirutin decreases cholesterol levels and fat levels in liver tissue, and thus can be utilized as a composition or food for preventing and treating liver diseases. In addition, the present invention relates to a method for extracting narirutin from citrus peel, and a method for preparing citrus fermented milk using the same.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: August 8, 2017
    Assignee: Korea Food Research Institute
    Inventors: In Wook Choi, Yong Kon Park, Yoon Sook Kim, Hee Don Choi, Ho Young Park
  • Patent number: 9688711
    Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: June 27, 2017
    Assignee: Achaogen, Inc.
    Inventors: James Bradley Aggen, Adam Aaron Goldblum, Martin Sheringham Linsell, Paola Dozzo, Heinz Ernst Moser, Darin James Hildebrandt, Micah James Gliedt
  • Patent number: 9609884
    Abstract: Anti-fatigue agents containing dioxabicyclo[3.3.0]octane derivatives such as sesamin which is an ingredient contained in sesame, as well as pharmaceutical compositions and physiologically functional foods that contain such anti-fatigue agents are disclosed. These compounds can safely be administered to humans and animals alike and hence allow for continued ingestion while proving effective in promoting an improvement of stamina, an increase of body strength, a relief of fatigue, and recovery from fatigue.
    Type: Grant
    Filed: March 12, 2008
    Date of Patent: April 4, 2017
    Assignee: Suntory Holdings Limited
    Inventors: Yoshiko Ono, Kayo Saito, Norifumi Tateishi, Akifumi Maeda
  • Patent number: 9610276
    Abstract: Compositions and methods for providing anti-diabetic and anti-hyperlipidemia benefits to diabetic subjects currently on medication but not meeting recommended targets for blood glucose, HbA1c, blood pressure and total cholesterol.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: April 4, 2017
    Assignee: KGK Synergize, Inc.
    Inventor: Najla Guthrie
  • Patent number: 9603862
    Abstract: The invention provides a method of increasing a deacetylase activity of SIRT5 by contacting SIRT5 with an agent that binds SIRT5 and reduces the Km of SIRT5 for a substrate, thereby increasing the deacetylase activity of SIRT5. The invention also provides a method for treating a urea cycle disorder in a mammal, as well as a method of assaying a sirtuin modulator.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: March 28, 2017
    Assignee: CORNELL UNIVERSITY
    Inventors: Anthony Sauve, Yana Cen
  • Patent number: 9562037
    Abstract: The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: February 7, 2017
    Assignee: The Hong Kong Polytechnic University
    Inventors: Larry Ming-Cheung Chow, William Tak Hang Chan, Kin-Fai Chan, Iris Lai King Wong, Wing-Yiu Kan
  • Patent number: 9549883
    Abstract: Cosmetic antiperspirants for nonaerosol use, having a content of methanesulfonic acid and/or at least one physiologically acceptable salt of methanesulfonic acid, which exhibit less textile staining than known antiperspirants.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: January 24, 2017
    Assignee: Henkel AG & Co. KGaA
    Inventors: Bernhard Banowski, Marcus Claas
  • Patent number: 9498413
    Abstract: This disclosure provides generally for antimicrobial compositions and methods of use comprising an anthocyanin, an anthocyanidin or metabolites thereof. Methods for promoting healing of a wound using these compositions are also disclosed. These compositions have broad spectrum antimicrobial activity and are safe for human and animal uses. Further, these compositions are safe for medical uses and industrial uses as antiseptic preparations to reduce or prevent microbial growth.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: November 22, 2016
    Inventor: Lanny Leo Johnson
  • Patent number: 9492427
    Abstract: The invention provides compounds, methods, pharmaceutical compositions, and kits for the treatment of proliferative disorders such as cancer. In one aspect, the methods comprise compounds that inhibit the activity of protein kinases, such as cell division cycle (Cdc) kinase. In another aspect, the methods comprise compounds that inhibit Cdc7 and/or Dbf4 activity. In another aspect, the methods comprise compounds that exhibit anti-proliferative properties useful in treating diseases such as cancer. Compounds useful for any of the methods include compounds of the Formula (A) or (B): or pharmaceutically acceptable salts thereof. Exemplary compounds of Formula (A) or (B) include granaticin A, granaticin B, dihydrogranaticin A, dihydrogranaticin B, medermycin, and actinorhodin.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: November 15, 2016
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Mark G. Frattini, Hakim Djaballah, Thomas J. Kelly
  • Patent number: 9452192
    Abstract: Disclosed is a composition for preventing or improving metabolic syndrome, including a tea plant leaf extract, a tea plant flower extract and a tea plant seed extract as active ingredients.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: September 27, 2016
    Assignee: AMOREPACIFIC CORPORATION
    Inventors: Su Kyung Kim, Hyun Jung Shin, Chan Su Rha, Seung Hun Kim, Bum Jin Lee, Young Kyung Kim, Dae Bang Seo, Wan Gi Kim, Jin Oh Chung, Sang Jun Lee
  • Patent number: 9440942
    Abstract: Methods for the prevention and/or alleviation of androgen-mediated disorders treatable by administering a chroman-derived anti-androgen compound are provided by the present invention. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived anti-androgen compounds useful in the prevention and/or alleviation of androgen-mediated disorders, particularly prostate cancer.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: September 13, 2016
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Todd A. Thompson, George Wilding
  • Patent number: 9434900
    Abstract: A liquid fuel composition containing: (a) a gasoline base fuel suitable for use in an internal combustion engine; and (b) one or more organic sunscreen compounds.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: September 6, 2016
    Assignee: Shell Oil Company
    Inventors: Mark Lawrence Brewer, Michael William Howe
  • Patent number: 9427002
    Abstract: Edible compositions useful for weight management in male animals are disclosed. The compositions comprise one or more isoflavones or isoflavone metabolites and are particularly useful for reducing or preventing the accumulation of body fat. Also disclosed are methods useful for weight management in an animal utilizing compositions comprising one or more isoflavones. The compositions and methods are particularly useful for the reduction or prevention of body fat accumulation during periods of excess caloric intake, and preferably have a sparing effect on lean body mass.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: August 30, 2016
    Assignee: Nestec S.A.
    Inventor: Yuanlong Pan
  • Patent number: 9428716
    Abstract: The present invention relates to the use of oligohydroxybenzoic acid derivatives in washing and cleaning agents in order to improve washing or cleaning performance with respect to bleachable stains.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: August 30, 2016
    Assignee: Henkel AG & Co. KGaA
    Inventors: Christian Kropf, Mareile Job, Christian Umbreit, Siglinde Erpenbach
  • Patent number: 9428533
    Abstract: The present invention provides compounds of the formula, wherein A, B, G, R2, R6, and X are defined herein, pharmaceutical compositions of the same, and methods for treating or inhibiting development of AGE- and/or ALE-associated complications in subjects in need thereof.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: August 30, 2016
    Assignee: Nephrogenex, Inc
    Inventors: Raja G. Khalifah, Roger E. Marti
  • Patent number: 9393276
    Abstract: The present invention provides relates to an edible composition for anti-diabetic benefit. Diabetes is one of the major and commonly occurring health problems in today's world. Pharmaceuticals companies are very active in this field to develop new medicines for preventing and controlling diabetes. There are several medicines available in the market for the treatment of type 2 diabetes. There are also prior arts which describes composition for the prevention of glucose intolerance and/or diabetes. We have found that though prior that discloses compositions for prevention of glucose intolerance and/or diabetes, it is not that effective for preventing diabetes. The present inventors while working extensively for providing an edible composition for preventing diabetes have surprisingly found that a particular combination of Inula racemosa and theobromine is effective for controlling and/or preventive diabetes thereby satisfying one or more of the aforesaid objects.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: July 19, 2016
    Assignee: Conopco, Inc.
    Inventors: Gautam Banerjee, Vinitha Kadamkode, Ramitha Kalathil, Suman Majumder
  • Patent number: 9371277
    Abstract: Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntington's disease.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: June 21, 2016
    Assignees: Northwestern University, The General Hospital Corporation
    Inventors: Richard B. Silverman, Hua Wang, Mohammad Khanfar, Aleksey G. Kazantsev
  • Patent number: 9333192
    Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating bone remodeling, and prevention and treatment of osteoporosis.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: May 10, 2016
    Assignee: SINOVEDA CANADA, INC
    Inventors: Yun Kau Tam, Yi-Chan James Lin, Brian Duff Sloley, Chih-Yuan Tseng
  • Patent number: 9320781
    Abstract: The present invention relates to a dietary supplement and methods of use thereof. More particularly, the invention relates to a composition including a kiwifruit extract in combination with an amylase inhibitor and/or a bifunctional protease-amylase inhibitor, particularly, but not exclusively, for managing gut health or for the treatment or prevention of digestive dysfunction, gastrointestinal disorders or symptoms thereof.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: April 26, 2016
    Assignee: VITAL FOODS LIMITED
    Inventors: Kawal Matharu, Iona Weir
  • Patent number: 9289444
    Abstract: This invention relates to a composition for promoting hematopoiesis and for treating, preventing or alleviating cytopenia or bone marrow failure comprising quercetin 3-O-?-(2?-galloyl)-rhamnopyranoside (QGR) as active ingredient.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: March 22, 2016
    Assignee: Chungbuk National University Industry Academic Cooperation Foundation
    Inventors: Byeong Woo Ahn, Young Soo Kim, Heon Sang Jeong, Sang-Kyung Shin, Tae-Wang Kim, So-Young Youm
  • Patent number: 9273085
    Abstract: The present invention provides pyrazole derivatives, uses thereof for medical purposes and so on. More particularly, the present invention relates to pharmaceuticals useful for the prevention or treatment of constipation, which comprise as an active ingredient 3-(3-{4-[3-(?-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}propylamino)-2,2-dimethylpropionamide, or a pharmaceutically acceptable salt thereof. The pharmaceuticals of the present invention exert an effect of increasing the frequency of bowel movement or the like, and are useful for the prevention or treatment of constipation.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: March 1, 2016
    Assignee: KISSEI PHARMACEUTICAL CO., LTD.
    Inventors: Masayuki Isaji, Masaaki Takemura, Hidetoshi Isawa, Yukihiko Hotei, Itaru Miyashita