The Hetero Ring Has 8 Or More Ring Carbons Patents (Class 514/28)
  • Patent number: 10426808
    Abstract: Natural plant parts and extracts of plants selected from the group consisting of Quercus infectoria, Rhus chinensis and Terminalia chebula containing compounds such as gallic acid, derivative of gallic acid, gallotannins and hydrolysable tannins have been found to control coccidiosis in poultry and, more specifically, coccidiosis caused by Eimeria spp. The plant parts and natural extracts result in a reduction of lesion score, oocysts per gram of fecal matter and mortality.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: October 1, 2019
    Assignee: KEMIN INDUSTRIES, INC.
    Inventors: Gokila Thangavel, Rajalekshmi Mukkalil, Haridasan Chirakkal, Hannah Kurian, Elke Schoeters, Hilde Wouters, Ilse Mast
  • Patent number: 10376578
    Abstract: In alternative embodiments, the invention provides a “triple combination” therapy for treating, ameliorating and preventing Crohn's Disease (or Crohn syndrome, terminal or distal ileitis or regional enteritis) or related disorders and conditions in mammals, such as paratuberculosis in mammals, or Johne's disease, including genetically-predisposed and chronic disorders, where the microbial or bacterial flora of the bowel is at least one causative or symptom-producing factor; and compositions for practicing same. In alternative embodiments, methods and compositions of the invention comprise or comprise use of therapies, medications, formulations and pharmaceuticals comprising active agents that can suppress or eradicate the microbiota super-infection that causes Crohn's Disease or paratuberculosis infection in mammals.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: August 13, 2019
    Inventor: Gaurav Agrawal
  • Patent number: 10197560
    Abstract: Embodiments of the invention relate to methods and systems for the detection of Mycobacterium tuberculosis. Mycobacterium tuberculosis kills more than one million people each year. To better understand why M. tuberculosis is virulent and to discover chemical markers of this pathogen, we compared its lipid profile to that of the attenuated but related mycobacterium, Mycobacterium bovis Bacille Calmette Guerin (BCG). This strategy identified previously unknown compounds that are specific to M. tuberculosis, e.g. 1-tuberculosinyladenosine, N6-tuberculosinyladenosine, and various tuberculosinyladenosines having mycolic acids, produced by the Rv3378c enzyme.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: February 5, 2019
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: David Branch Moody, Emilie Layre, David C. Young
  • Patent number: 10131684
    Abstract: Described herein are processes for the preparation of compounds of formula (I): and pharmaceutically acceptable salts, solvates, and hydrates thereof.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: November 20, 2018
    Assignee: CEMPRA PHARMACEUTICALS, INC.
    Inventors: David Eugene Pereira, Manish K. Patel, Keshav Deo
  • Patent number: 10111880
    Abstract: The present invention is directed to use of a series of tri-aryl compounds and compositions comprising the same for the treatment of diabetes and disease conditions arising as a consequence of the same.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: October 30, 2018
    Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventor: Esther Priel
  • Patent number: 10105342
    Abstract: The present application relates to compounded compositions, methods of making compounded compositions, and methods of using compounded compositions. For example, disclosed herein are compounded compositions and methods of making compounded compositions comprising one or more anti-infective agents such as mupirocin.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: October 23, 2018
    Assignee: CMPD LICENSNG, LLC
    Inventor: Jay Richard Ray, II
  • Patent number: 10028949
    Abstract: There may be provided compositions of lipophilic pharmaceutical agents with improved solubility and stability. For example, there may be provided a non-aqueous composition that comprises a lipophilic pharmaceutical agent, and an amphiphilic polymeric solvent such as PEG400 but essentially free of organic solvents and non-solubilized particles. The composition may be further diluted with a desired aqueous diluent such as an infusion fluid for parenteral administration to a subject such as a human. The compositions may be useful for the treatment for diseases or conditions that are sensitive to lipophilic agents, such as infectious diseases, malignant or autoimmune diseases.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: July 24, 2018
    Assignee: Platform Brightworks Two, Ltd.
    Inventors: Borje S. Andersson, Benigno C. Valdez, Jeffrey Tarrand
  • Patent number: 9982005
    Abstract: Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: May 29, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
  • Patent number: 9901592
    Abstract: Described herein are macrolide and ketolide antibiotics and pharmaceutical compositions, methods, and uses thereof for treating diseases caused at least in party by resistant bacteria.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: February 27, 2018
    Assignee: CEMPRA PHARMACEUTICALS, INC.
    Inventors: Prabhavathi Fernandes, David E. Pereira
  • Patent number: 9775351
    Abstract: The present invention relates to novel mixtures, to processes for preparing these compounds, to compositions comprising these mixtures, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms or pests in crop protection and in the protection of materials and for enhancing plant health.
    Type: Grant
    Filed: November 28, 2013
    Date of Patent: October 3, 2017
    Assignee: BAYER CROPSCIENCE AG
    Inventors: Haruko Sawada, Stefan Herrmann, Heiko Rieck, Christophe Dubost
  • Patent number: 9682126
    Abstract: To provide a therapeutic agent for gastrointestinal disorder such as diabetic gastroparesis. A postprandial gastrokinetic agent containing (A) ghrelin or a ghrelin agonist and (B) motilin or a motilin agonist as active ingredients, in which both the ingredients (A) and (B) are administered so as to act on the stomach after food intake.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: June 20, 2017
    Assignees: ZERIA PHARMACEUTICAL CO., LTD., SAITAMA UNIVERSITY
    Inventors: Takafumi Sakai, Ichiro Sakata, Kayuri Kuroda, Makoto Yoshimura
  • Patent number: 9675659
    Abstract: Methods for the treatment and/or prevention of a fungal infection in the pulmonary system of a subject in need thereof with caspofungin or a derivative thereof are disclosed herein.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: June 13, 2017
    Assignee: Trilogy Therapeutics, Inc.
    Inventors: David M. Ryckman, Iching G. Yu
  • Patent number: 9669044
    Abstract: The present invention relates to novel fungicidal compound including an aminoglycoside analog having certain substituents at the 6 position of ring III that exhibit improved antifungal activity but possess minimal antibacterial properties in combination with fungicidal azoles. The aminoglycoside compounds are analogues of kanamycin A. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating or preventing fungal disease.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: June 6, 2017
    Assignee: Utah State University
    Inventors: Jon Y. Takemoto, Cheng-wei Tom Chang, Sanjib K. Shrestha, Michelle Grilley
  • Patent number: 9662346
    Abstract: A method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by an insect or arthropod sting or bite, or a skin contact with a noxious weed or plant is disclosed. The method includes topically applying a dermatological composition containing an avermectin compound to an affected area immediately after said sting or bite, or said skin contact occurs. The method further includes moistening the affected area first prior to application of the dermatological composition.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: May 30, 2017
    Assignee: Galderma S.A.
    Inventors: Jeffrey D. Parks, L. Dean Parks
  • Patent number: 9655946
    Abstract: Lyophilized daptomycin formulations having improved reconstitution times are provided. The lyophilized daptomycin formulations include an additive, which can be a pharmaceutically acceptable antioxidant, a pharmaceutically acceptable organic acid or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable glucose derivative or a pharmaceutically acceptable salt thereof, or a combination thereof. Also provided are methods of methods of preparing the lyophilized daptomycin formulations, and methods of treating bacterial infections and treating or preventing biofilms by using the lyophilized daptomycin formulations.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: May 23, 2017
    Assignee: HOSPIRA AUSTRALIA PTY LTD.
    Inventors: Jim Alexiou, Andrew Knill, Noel Norris, Darryl Whittaker
  • Patent number: 9480679
    Abstract: Described herein are formulations and methods for treating diseases caused by infectious pathogens, including mycobacterium avium complex, mycobacterium tuberculosis, Nocardia, Plasmodium falcium, and Plasmodium berghei.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: November 1, 2016
    Assignee: CEMPRA PHARMACEUTICALS, INC.
    Inventor: Prabhavathi Fernandes
  • Patent number: 9457038
    Abstract: Administration of at least one compound of the family of the avermectins or of the family of the milbemycins, notably ivermectin, is useful for the treatment of ophthalmic pathologies, including ocular rosacea.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: October 4, 2016
    Assignee: GALDERMA S.A.
    Inventors: Alexandre Kaoukhov, Christophe Villard, Philippe Bouissou
  • Patent number: 9392792
    Abstract: The present invention relates to a liquid topical veterinary pharmaceutical composition consisting of fipronil, permethrin at high concentration and pyriproxyfen such that it does not crystallize when it is applied to the coat of an animal, and to the use thereof in the prevention and/or treatment of infestations of domestic animals by external parasites. The present invention also relates to the use of pyriproxyfen as an inhibitor of the crystallization of a liquid formulation comprising fipronil and permethrin at high concentration.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: July 19, 2016
    Assignee: VIRBAC
    Inventor: Nathalie Delhom
  • Patent number: 9320786
    Abstract: The invention provides methods of treating or preventing malaria comprising administering to an animal an effective amount of a compound of formula (I): Q-Y—R1—R2 (I), wherein Q, Y, R1, and R2 are as described herein. Methods of inhibiting a plasmodial surface anion channel of a parasite in an animal are also provided. The invention also provides pharmaceutical compositions comprising a compound represented by formula (I) in combination with any one or more compounds represented by formulas II, V, and VI. Use of the pharmaceutical compositions for treating or preventing malaria or for inhibiting a plasmodial surface anion channel in animals including humans are also provided. Also provided by the invention are clag3 amino acid sequences and related nucleic acids, vectors, host cells, populations of cells, antibodies, and pharmaceutical compositions.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: April 26, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventor: Sanjay A. Desai
  • Patent number: 9220719
    Abstract: This invention provides a single-dose oral formulation of spinosad for the extended control of a C. felis infestation on a cat at a predictable dose of spinosad that is suitable for administration once every 30 days (i.e., one month). The invention also provides methods of using the formulation of spinosad.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: December 29, 2015
    Assignee: ELI LILLY AND COMPANY
    Inventors: Kari Lynette Riggs, Daniel Earl Snyder, Michelle Leigh Totten
  • Patent number: 9161906
    Abstract: The present invention refers to pharmaceutical formulations based on lipids for ophthalmic use comprising a phospholipid component composed of zwitterionic phospholipids of natural origin and an oily component composed of oils of natural origin emulsified in water. In particular, the invention refers to ophthalmic formulations useful, for example, for transporting drugs to the eye and in the treatment of ocular dryness, capable of restoring the lipid layer of the tear film. In particular, in a non-transitory but pathological situation such as the dry eye syndrome, such formulations also succeed in reducing the often-present inflammatory component.
    Type: Grant
    Filed: December 24, 2007
    Date of Patent: October 20, 2015
    Assignee: SIFI, S.P.A.
    Inventors: Maria Grazia Mazzone, Valeria Maria Carmela Moschetti, Fausto Giuseppe Miano, Letizia Gaetana Lo Grasso
  • Patent number: 9066964
    Abstract: The invention relates to the use of a macrolide antibiotic, tylvalosin, as an anti-viral agent. Tylvalosin is particularly useful for the treatment of PRRSV.
    Type: Grant
    Filed: July 13, 2007
    Date of Patent: June 30, 2015
    Assignees: Cambridge University Technical Services, Eco Animal Health Limited
    Inventors: Albert Philip Adrian Mockett, Thomas David Kay Brown, Amanda Denise Stuart
  • Patent number: 9044508
    Abstract: Provided is concentrated aqueous azithromycin formulation from about from about 2%-20%, and a method of making a concentrated aqueous azithromycin formulation which includes preparing and sterilizing a first solution comprising a strong base to form a sterilized solution, dissolving the azithromycin in an aqueous solution comprising an acid consisting essentially of a strong acid, and adding the aqueous solution comprising the strong acid to the sterilized solution comprising the strong base. The strong acid has a pKa less than about ?1.74 and the method is carried out without addition or use of a weak acid.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: June 2, 2015
    Assignee: INSITE VISION CORPORATION
    Inventors: Lyle M. Bowman, Sui Yen Eddie Hou, Tang Nguyen
  • Publication number: 20150141356
    Abstract: The present invention relates to methods of preventing and/or treating Clostridium difficile infection (CDI) in a subject at high risk for developing CDI including subjects receiving antibiotic therapy for a different infection comprising administering to the subject an effective amount of the compounds described herein.
    Type: Application
    Filed: November 14, 2014
    Publication date: May 21, 2015
    Inventors: Sherwood Gorbach, Pamela Sears, Yoshi Ichikawa
  • Patent number: 9034835
    Abstract: According to the present invention, a plant disease control agent having a superior control effect on plant diseases at a low dose is provided. The plant disease control agent of the present invention includes at least one selected from tetrazolyl oxime derivatives represented by formula (I) and salts thereof, and at least one selected from the group consisting of imidacloprid, triflumizole, spinosad, hydroxy isoxazole, thiophanate-methyl, tricyclazole, clothianidin, benomyl, acetamiprid and salts thereof. In formula (I), X represents a C1-6 alkyl group or the like; n represents an integer of 0 to 5; Y represents a C1-6 alkyl group; Z represents a group represented by NHC(?O)-Q; Q represents a C1-8 alkoxy group or the like; R represents a halogen atom; m represents an integer of 0 to 3.
    Type: Grant
    Filed: March 14, 2011
    Date of Patent: May 19, 2015
    Assignee: Nippon Soda Co., Ltd.
    Inventor: Ichirou Urihara
  • Patent number: 9018158
    Abstract: The invention provides a method of overcoming resistance to at least one antibiotic in a multidrug resistant bacterium, said method comprising contacting said bacterium with an alginate oligomer together with the antibiotic. The multidrug resistant bacterium may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antibiotic in treating a subject infected, suspected to be infected, or at risk of infection, with a multidrug resistant bacterium to overcome resistance to the antibiotic in said multidrug resistant bacterium. In another aspect the method can be used to combat contamination of a site with multidrug resistant bacteria, e.g. for disinfection and cleaning purposes.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: April 28, 2015
    Assignee: Algipharma AS
    Inventors: Edvar Onsoyen, Rolf Myrvold, Arne Dessen, David Thomas, Timothy Rutland Walsh
  • Publication number: 20150111743
    Abstract: A pesticidal composition comprises a synergistically effective amount of a nicotinic acetylcholine receptor (nAChR) allosteric activator compound and a pesticide selected from N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl)thio) propanamide (I), N-(3-chloro-1-(pyridine-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl)sulfinyl) propanamide (II), or any agriculturally acceptable salt thereof. A method of controlling pests comprises applying the pesticidal composition near a population of pests. A method of protecting a plant from infestation and attack by insects comprises contacting the plant with the synergistic pesticidal composition.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: Luis E. Gomez, Ricky Hunter, Mike Shaw, Tony K. Trullinger, Mary E. Kubiszak, John Herbert
  • Patent number: 8974807
    Abstract: The novel active compound combinations of extracts from seeds of the neem tree and the active compounds of groups (B) to (F) listed in the description have very good insecticidal and acaricidal properties.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: March 10, 2015
    Assignee: Bayer Cropscience AG
    Inventors: Gerhard Baron, Michael Kilian, Frank Rosenfeldt
  • Publication number: 20150045313
    Abstract: Provided are novel methods and formulations for topically controlling ectoparasite infestations in animals using spinetoram or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 28, 2014
    Publication date: February 12, 2015
    Inventors: Jeffrey Alan Meyer, William Hunter White, Joseph Raymond Winkle
  • Publication number: 20150037306
    Abstract: The present invention relates to a method for controlling insects comprising the steps of preparing a tankmix by mixing a larvicide and a liquid adjuvant, wherein the adjuvant is essentially free of the larvicide and contains at least 1 wt % polyorganosiloxane, and at least 20 wt % synthetic organic solvent; and applying the tankmix on a water surface. The invention further relates to a liquid adjuvant for preparing a larvicidal tankmix, wherein the adjuvant is essentially free of a larvicide and contains at least 1 wt % polyorganosiloxane, and at least 20 wt % synthetic organic solvent. Finally, it relates to a method for preparing said adjuvant, comprising mixing the polyorganosiloxan and the synthetic organic solvent.
    Type: Application
    Filed: January 21, 2013
    Publication date: February 5, 2015
    Applicant: BASF SE
    Inventors: Claude Taranta, Helmut Mueller, Susanne Stutz, Egon Weinmueller, James W. Austin
  • Publication number: 20150033418
    Abstract: A first aspect of the invention is an agricultural composition comprising nanoparticles, an agrochemical active ingredient in the nanoparticles, and optionally (but in some embodiments preferably) a carrier for the nanoparticles. In some embodiments, the nanoparticles are viral particles or capsids, particularly plant viral particles or capsids. In some embodiments, the carrier comprises an inert or biodegradable carrier (e.g., a solid carrier) to which the nanoparticles are bound or in which the nanoparticles are suspended. In some embodiments, the carrier comprises inert or biodegradable polymer fibers.
    Type: Application
    Filed: April 16, 2013
    Publication date: January 29, 2015
    Inventors: Steven A. Lommel, Julie Willoughby, Richard Guenther
  • Publication number: 20150031640
    Abstract: It has been determined that co-administration of a rifamycin and a switch-region inhibitor 1) results in synergistic antibacterial effects, enabling efficacy at low, subtoxic doses, and/or 2) results in a low spontaneous resistance frequency, enabling treatment of high-titer infections without treatment failure due to spontaneous resistance. Accordingly, certain embodiments provide composition comprising a rifamycin and a switch region inhibitor, as well as methods of use thereof.
    Type: Application
    Filed: February 5, 2013
    Publication date: January 29, 2015
    Inventor: Richard H. Ebright
  • Publication number: 20150011487
    Abstract: Pest controlling compositions exhibiting enhanced pesticidal activity levels are disclosed. In one embodiment, a composition includes at least one pesticide, at least one transition metal salt and least one proteinaceous material. In this embodiment, the composition exhibits enhanced pesticidal activity levels compared to a composition dissimilar only in not having the at least one transition metal salt and the at least one proteinaceous material.
    Type: Application
    Filed: June 5, 2014
    Publication date: January 8, 2015
    Inventors: Stephen L. Wilson, Lei Liu, James D. Thomas, Raymond E. Boucher, JR., James E. Dripps, Margaret S. Kempe
  • Patent number: 8921327
    Abstract: Provided are novel methods and formulations for topically controlling ectoparasite infestations in animals using spinetoram, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: December 30, 2014
    Inventor: Joseph Raymond Winkle
  • Patent number: 8912150
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: December 16, 2014
    Assignees: Melinta Therapeutics, Inc., Yale University
    Inventors: Thomas A. Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
  • Publication number: 20140357585
    Abstract: Pest controlling compositions exhibiting enhanced pesticidal activity levels are disclosed. In one embodiment, a composition includes at least one pesticide, at least one proteinaceous material and at least one polymeric material. In this embodiment, the composition exhibits enhanced pesticidal activity levels compared to a composition dissimilar only in not having the at least one proteinaceous material and the at least one polymeric material. Still, alternative embodiment pesticide compositions exhibiting enhanced activity levels are disclosed.
    Type: Application
    Filed: May 2, 2014
    Publication date: December 4, 2014
    Applicant: Dow AgroSciences, LLC
    Inventors: Stephen L. Wilson, Lei Liu, James D. Thomas, Raymond E. Boucher, JR., James E. Dripps, Margaret S. Kempe
  • Publication number: 20140349953
    Abstract: A Maillard reaction inhibitor which effectively inhibits the progress of a Maillard reaction in a living body, can be safely applied without adverse side effects, can be manufactured without any complicated process, a skin anti-aging agent, an anti-diabetic complication agent and foods and beverages using the same. The Maillard reaction inhibitor contains 50 to 90% by mass of polyphenol as an active ingredient. The Maillard reaction inhibitor has a potent Maillard reaction inhibitory activity in a living body and allows for the prevention and improvement of the various dysfunction of protein in a living body. Due to this activity, the Maillard reaction inhibitor suppresses aging and can prevent and/or treat diabetic complications. Furthermore, when the above-described tannin is mixed in foods and beverages containing collagen, it is possible to suppress the Maillard reaction in the foods and beverages to suppress the deterioration of the foods and beverages.
    Type: Application
    Filed: December 27, 2012
    Publication date: November 27, 2014
    Inventors: Norihisa Nishida, Akifumi Nagatomo, Hideyuki Ito
  • Publication number: 20140336048
    Abstract: A pesticidal mixture comprising as active ingredient a mixture of component A and component B, wherein component A is a compound of formula (I), in which Q is i or ii wherein X, Y and Z, m and n, A, G, and R, are as defined as in claim 1, and component B is a compound selected from the following insecticides: a), pymetrozine; b). a pyrethroid selected from the group consisting of cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin; c). a macrolide selected from the group consisting of abamectin, emamectin benzoate, and spinetoram; d). a diamide selected from the group consisting of chlorantraniliprole and cyantraniliprole; e). thiamethoxam; f). sulfoxaflor; g). cyenopyrafen. The present invention also relates to methods of using said mixtures for the control of plant pests.
    Type: Application
    Filed: November 29, 2012
    Publication date: November 13, 2014
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Anke Buchholz, Fabienne Hatt, Alfred Rindlisbacher, Michel Muehlebach
  • Patent number: 8877719
    Abstract: A pest controlling composition comprising spinetoram and a cyclic keto-enol compound having an acetyl CoA carboxylase-inhibiting activity as active ingredients.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: November 4, 2014
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Yasutaka Shimokawatoko, Emiko Sakamoto, Mayuko Ozawa
  • Patent number: 8871727
    Abstract: Provided are novel methods and formulations for topically controlling ectoparasite infestations in animals using spinetoram or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: October 28, 2014
    Assignee: Eli Lilly and Company
    Inventors: Jeffery Alan Meyer, William Hunter White, Joseph Raymond Winkle
  • Publication number: 20140315840
    Abstract: Insect controlling compositions including an N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximine compound exhibiting increased stability, along with methods for preparing same, are disclosed.
    Type: Application
    Filed: July 1, 2014
    Publication date: October 23, 2014
    Inventors: Kuide Qin, Raymond E. Boucher, Jr.
  • Publication number: 20140315838
    Abstract: The present invention relates to methods of treating a recurring gastrointestinal (GI) infection of Clostridium difficile in a subject comprising administering to the subject an effective amount of the compounds of the present invention.
    Type: Application
    Filed: June 28, 2013
    Publication date: October 23, 2014
    Applicant: Optimer Pharmaceuticals, Inc.
    Inventors: Youe-Kong Shue, Sherwood Gorbach, Pamela Sears
  • Publication number: 20140315839
    Abstract: Provided is a pest control composition containing a novel iminopyridine derivative and other pest control agents. Provided is a pest control composition containing an iminopyridine derivative represented by the following Formula (I) and at least one of other pest control agents: [in the formula (I), Ar represents a 5- to 6-membered heterocycle which may be substituted, A represents a heterocycle having a 5- to 10-membered unsaturated bond including one or more nitrogen atoms, and has an imino group substituted with an R group at a position adjacent to the nitrogen atom present on the cycle, Y represents hydrogen, halogen and the like, and R represents any one of groups represented by the following Formulae (a) to (e), (y) or (z)].
    Type: Application
    Filed: July 1, 2014
    Publication date: October 23, 2014
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Ryo HORIKOSHI, Yasumichi ONOZAKI, Satoshi NAKAMURA, Masahiro NOMURA, Makoto MATSUMURA, Masaaki MITOMI
  • Patent number: 8858967
    Abstract: Pharmaceutical cream-gel compositions useful for the treatment of a variety of dermatological conditions, disorders and afflictions, in particular of rosacea, contain at least one avermectin compound active principle, and which also contain an oily phase dispersed in an aqueous phase by means of a non-surfactant polymeric emulsifier, the oily phase comprising oils having a melting point below 30° C. and being free of solid fats having a melting point above 30° C., formulated into a physiologically acceptable medium therefor.
    Type: Grant
    Filed: September 18, 2006
    Date of Patent: October 14, 2014
    Assignee: Galderma S.A.
    Inventors: Fanny Astruc, Sandrine Orsoni, Laurent Fredon
  • Patent number: 8859510
    Abstract: The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to Clostridium difficile (“C. difficile”), Clostridium perfringens (“C. perfringens”), Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: October 14, 2014
    Assignee: Optimer Pharmaceuticals, Inc.
    Inventors: Yu-Hung Chiu, Tessie Mary Che, Alex Romero, Yoshi Ichikawa, Youe-Kong Shue
  • Publication number: 20140303104
    Abstract: Pest controlling compositions exhibiting enhanced pesticidal activity levels and methods for preparing the same are disclosed. In one embodiment, a method includes providing a liquid composition that includes at least one pesticide and at least one co-ingredient that enhances pesticidal activity of the composition compared to a composition dissimilar only in not having the at least one co-ingredient. The at least one co-ingredient may include at least one metal oxide, a combination of at least transition metal salt and at least one proteinaceous material or a combination of at least one proteinaceous material and at least one polymeric material. The method further includes spray drying the liquid composition to provide a solid composition. In one aspect of this embodiment, the solid composition provided by the spray drying exhibits enhanced pesticidal activity compared to the liquid composition.
    Type: Application
    Filed: June 19, 2014
    Publication date: October 9, 2014
    Inventors: Stephen L. Wilson, Lei Liu, James D. Thomas, Raymond E. Boucher, JR., James E. Dripps, Margaret S. Kempe, Martin C. Logan, Douglas J. Linscott, John M. Atkinson
  • Patent number: 8841322
    Abstract: Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compounds are effective to enhance glucocerebrosidase activity.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: September 23, 2014
    Assignee: Mount Sinai School of Medicine of New York University
    Inventors: Jian-Qiang Fan, Satoshi Ishii, Naoki Asano
  • Publication number: 20140274686
    Abstract: Canola seed treated with spinetoram controls flea beetle.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicant: Dow AgroSciences LLC
    Inventors: William H. Hendrix, III, Gary C. Turnbull
  • Publication number: 20140274687
    Abstract: Canola seed treated with spinosad controls flea beetle.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicant: Dow AgroSciences LLC
    Inventors: William H. Hendrix, III, Gary C. Turnbull
  • Publication number: 20140235442
    Abstract: A composition comprising at least a pyridylethylbenzamide derivative of general formula (I) (a) and an insecticide compound (b) in a (a)/(b) weight ratio of from 1/1000 to 1000/1. A composition further comprising an additional fungicidal compound. A method for preventively or curatively combating the pests and diseases of crops by using this composition.
    Type: Application
    Filed: April 25, 2014
    Publication date: August 21, 2014
    Inventors: Heike HUNGENBERG, Gilbert LABOURDETTE, Albert SCHIRRING, Burkhard SCHUETZ, Anne SUTY-HEINZE, Wolfgang THIELERT, Martin VAUPEL