Ring Nitrogen Is Shared By The Cyclos Of The Bicyclo Ring System (e.g., Tetramisole, Etc.) Patents (Class 514/368)
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Patent number: 6821993Abstract: This invention relates to a series of triazepines of Formula I and II, and pharmaceutical compositions containing them. The compounds of the invention have neurotrophic activity and are useful in the treatment and prevention of neuronal disorders such as Parkinson's disease, Alzheimer's disease, stroke, multiple sclerosis, amyotrophic lateral sclerosis diabetic neuropathy and Bell's palsy.Type: GrantFiled: October 4, 2002Date of Patent: November 23, 2004Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Zhihua Sui, Shawn P. Walsh
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Patent number: 6794359Abstract: The invention relates to a vertebrate intestinal protein which absorbs cholesterol. It was possible to identify the protein by means of high-affinity crosslinking compounds. The invention further relates to this use of the protein for carrying out a method for identifying a compound which inhibits cholesterol absorption in the intestine.Type: GrantFiled: August 28, 2001Date of Patent: September 21, 2004Assignee: Aventis Pharma Deutschland GmbHInventors: Werner Kramer, Heiner Glombik
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Patent number: 6770642Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.Type: GrantFiled: December 19, 2002Date of Patent: August 3, 2004Assignee: WyethInventors: Derek Cecil Cole, Joseph Raymond Stock, William Joseph Lennox, Ping Zhou
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Publication number: 20040122002Abstract: The present invention relates to fused pyrrole compounds of the formula 1.Type: ApplicationFiled: September 27, 2002Publication date: June 24, 2004Inventors: Hans Guenter Striegel, Stefan Laufer, Karola Tollmann, Susanne Tries
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Patent number: 6730686Abstract: The instant invention provides compositions and methods for modeling post-Amadori AGE formation and the identification and characterization of effective inhibitors of post-Amadori AGE formation, and such identified inhibitor compositions. The instant invention also teaches new methods to treat or prevent oxidative modification of proteins, including low density lipoproteins, to treat or prevent lipid peroxidation, and to treat or prevent atherosclerosis, comprising administering an amount effective of one of the compounds of the invention to treat or prevent the disorder.Type: GrantFiled: October 8, 1999Date of Patent: May 4, 2004Assignees: Kansas University Medical Center, University of South CarolinaInventors: John W. Baynes, Joelle Onorato, Suzanne Thorpe, Raja Khalifah, Billy G. Hudson
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Publication number: 20040063713Abstract: The present invention relates to the use of compounds of formula (I) 1Type: ApplicationFiled: May 23, 2003Publication date: April 1, 2004Inventors: Marlon D. Cowart, Steven P. Latshaw, Sherry L. Nelson, Andrew O. Stewart
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Patent number: 6696441Abstract: The present invention provides compounds that act to suppress p53 activity in mammalian cells, and a method to effectively suppress p53 activity in the cells of a mammal subject to a stress or pathology that is ameliorated by such suppression.Type: GrantFiled: August 11, 2000Date of Patent: February 24, 2004Assignee: The Regents of the University of CaliforniaInventors: Howard B. Cottam, Lorenzo M. Leoni, Dennis A. Carson
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Publication number: 20030232828Abstract: The present invention provides compounds of formula I and the use thereof for the treatment of central nervous system disorders related to or affected by the 5-HT6 receptor.Type: ApplicationFiled: June 3, 2003Publication date: December 18, 2003Applicant: WyethInventors: Ronald Charles Bernotas, Steven Edward Lenicek, Schuyler A. Antane, Ping Zhou, Yanfang Li
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Publication number: 20030232794Abstract: The present invention provides novel indole derivatives useful to inhibit cancer or sensitize cancer cells to chemotherapeutic agents, radiation or other anti-cancer treatments.Type: ApplicationFiled: February 11, 2003Publication date: December 18, 2003Inventors: Howard B. Cottam, Lorenzo M. Leoni, Dennis A. Carson
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Patent number: 6657064Abstract: A novel bicyclic imidazo-5-yl-amine derivative of Formula I, wherein X denotes CR5, N or S, and Y in the case where X denotes S, denotes CR6 or N and in all other cases denotes N, and methods for preparation thereof are disclosed. Also disclosed are methods for treating pain using the compound of Formula I, and pharmaceutical compositions comprising the compound of Formula I.Type: GrantFiled: April 8, 2002Date of Patent: December 2, 2003Assignee: Gruenenthal GmbHInventors: Matthias Gerlach, Corinna Maul
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Publication number: 20030143199Abstract: The present invention provides A therapeutic method to enhance the efficacy of interferon treatment comprising administering to a mammal subject to interferon treatment a compound which is an antagonist of the IL-4 or IL-13 signal transduction pathway in an amount effective to enhance said efficacy. The method includes treatment of diseases such as cancer, proliferative fibrotic diseases, viral diseases, or autoimmune diseases. The invention also includes the use of chemotherapeutic agents, radiation or other treatments in conjunction with the method of the invention.Type: ApplicationFiled: October 9, 2002Publication date: July 31, 2003Inventors: Dennis A. Carson, Howard B. Cottam, Lorenzo M. Leoni, Sylvie Barchechath
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Patent number: 6586426Abstract: There are disclosed &bgr;-sheet mimetics and methods relating to the same for imparting or stabilizing the &bgr;-sheet structure of a peptide, protein or molecule. In one aspect, the &bgr;-sheet mimetics are covalently attached at the end or within the length of the peptide or protein. The &bgr;-sheet mimetics have utility as protease inhibitors generally, including activity as serine protease inhibitors such as thrombin, elastase and Factor X.Type: GrantFiled: November 18, 1999Date of Patent: July 1, 2003Assignee: Molecumetics Ltd.Inventor: Michael Kahn
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Patent number: 6586419Abstract: A method for inactivating ocular viral pathogens and for treating associated lesions on tissue by means of selectively activating a tissue-associated photosensitizing agent with light. The photosensitizing agent, preferably tin ethyl etiopurpurin, is administered to a patient to concentrate within the lesionous target tissue of the eye. The photosensitizer-laden target tissue is irradiated with photoactivating light. In pre-clinical in vitro studies, the photoactivated photosensitizer drug within the lesionous target tissue inactivates both cell free Herpes simplex virus (HSV) and cell-associated HSV and cytomegalovirus (CMV). The use of PDT for treating ocular viral diseases reduces the toxicity to the biological system when compared with prior art therapeutic procedures.Type: GrantFiled: April 16, 1997Date of Patent: July 1, 2003Assignees: PDT Systems, Inc., The Regents of the University of CaliforniaInventors: David H. Crean, Baruch D. Kupperman
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Patent number: 6586452Abstract: The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.Type: GrantFiled: July 9, 2001Date of Patent: July 1, 2003Assignee: Merck & Co., Inc.Inventors: Thomas Shih, Steven L. Colletti, Michael H. Fisher, Peter T. Meinke, Howard C. H. Kuo, Prasun K. Chakravarty, Matthew J. Wyvratt, Sriram Tyagarajan, Richard Berger
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Publication number: 20030119842Abstract: Salts of a bicyclic, N-acylated imidazo-3-amine or an imidazo-5-amine of the formula: 1Type: ApplicationFiled: October 18, 2002Publication date: June 26, 2003Applicant: GRUENENTHAL GmbH.Inventors: Matthias Gerlach, Corinna Sundermann
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Patent number: 6440963Abstract: The treatment of neuromuscular dysfunction of the lower urinary tract by compounds which selectively inhibit the COX-2 isozyme is described. The compounds concerned inhibit the COX-2 isozyme with a potency at least 10-fold, and preferably at least 100-fold, greater than their potency on the COX-1 isozyme.Type: GrantFiled: October 1, 2001Date of Patent: August 27, 2002Assignee: Recordati S.A., Chemical and Pharmaceutical CompanyInventors: Amedeo Leonardi, Rodolfo Testa, Luciano Guarneri
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Patent number: 6395724Abstract: Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment inflammation, pain, fever and the like.Type: GrantFiled: June 7, 1999Date of Patent: May 28, 2002Assignee: Advanced Medicine, Inc.Inventors: J. Kevin Judice, Deborah L. Higgins, John H. Griffin
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Patent number: 6380228Abstract: The present invention is directed to peptidomimetic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.Type: GrantFiled: April 6, 2001Date of Patent: April 30, 2002Assignee: Merck & Co., Inc.Inventors: Craig A. Stump, Theresa M. Williams
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Patent number: 6362191Abstract: The invention concerns compounds of formula (I), wherein: A is a 5 membered heteroaryl ring, a bicyclic benzo system containing such a 5 membered heteroaryl ring or a bicyclic or tricyclic heteroaryl ring system with at least one bridgehead nitrogen and optionally a further 1-3 heteroatoms chosen from oxygen, sulfur and nitrogen; R1 is, for example, hydroxy, halo, amino, nitro, cyano, carboxy, thiol, C1-4alkanoyloxy, C1-4alkoxycarbonyl, dimethylaminomethyleneaminocarbonyl, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4alkoxy, optionally substituted phenyl, an optionally substituted 5- or 6-membered heteroaryl ring or hydroxyC1-4alkyl; n is 0-6; R2 and R3 are independently hydrogen or fluoro; R4 is, for example, C1-4alkyl; pharmaceutically acceptable salts and in vivo hydrolysable ester thereof; processes for their preparation; pharmaceutical compositions containing them and their use as antibacterial agents.Type: GrantFiled: February 18, 2000Date of Patent: March 26, 2002Assignee: Zeneca Ltd.Inventor: Stuart Dennett Mills
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Patent number: 6313090Abstract: The present invention provides a method for treating a parasitic infection in a subject infected with a parasite having a plastid-like organelle, comprising administering to the subject an infection treating amount of a thiopeptide in a pharmaceutically acceptable carrier. Methods for treating Cryptospordium, Toxoplasma or Plasmodium infection in a subject are also provided, each method comprising administering to the subject an infection treating amount of a thiopeptide in a pharmaceutically acceptable carrier.Type: GrantFiled: March 20, 2000Date of Patent: November 6, 2001Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Martin John Rogers, Thomas F. McCutchan, Glenn A. McConkey, Alexandra S. Fairfield
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Patent number: 6299865Abstract: Mammalian hair growth is reduced by applying to the skin an inhibitor of alkaline phosphatase other than cromoglycate or a salt thereof.Type: GrantFiled: May 2, 2000Date of Patent: October 9, 2001Inventors: Peter Styczynski, Gurpreet S. Ahluwalia
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Patent number: 6242470Abstract: The invention provides adamantane derivatives, a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.Type: GrantFiled: January 26, 1999Date of Patent: June 5, 2001Assignee: AstraZeneca ABInventors: Andrew Baxter, Stephen Brough, Thomas McInally, Michael Mortimore
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Patent number: 6177454Abstract: An amide derivative represented by the following general formula (I) or a salt thereof and a pharmaceutical composition containing the amide derivative and a pharmaceutically acceptable vehicle. The symbols in the formula have the following meanings wherein A: heteroarylene; X: bond, O, S, —NR5—, —NR5CO—, —NR5CONH—, —NR5SO2— or —NR5C(═NH)NH—; R1: —H, -optionally substituted lower alkyl, -optionally substituted aryl, -optionally substituted heteroaryl or -optionally substituted cycloalkyl; R2a, R2b: —H or -lower alkyl, which may be the same or different; R3: —H or -lower alkyl; R4a, R4b: —H or —OH, which may be the same different, or R4a and R4b are taken together to form ═O or ═N—O—lower alkyl; and R5: —H or -lower alkyl.Type: GrantFiled: February 29, 2000Date of Patent: January 23, 2001Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Tatsuya Maruyama, Kenichi Onda, Masahiko Hayakawa, Takumi Takahashi, Takayuki Suzuki, Tetsuo Matsui
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Patent number: 6159995Abstract: Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.Type: GrantFiled: May 8, 1998Date of Patent: December 12, 2000Assignee: Aventis Pharma Deutschland GmbHInventors: Werner Thorwart, Wilfried Schwab, Manfred Schudok, Burkhard Haase, Bernhard Neises, Gunter Billen
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Patent number: 6136804Abstract: The invention provides a method for treating, preventing, or reducing the risk of developing a condition selected from the group consisting of acute coronary ischemic syndrome, thrombosis, thromboembolism, thrombotic occlusion and reocclusion, restenosis, transient ischemic attack, and first or subsequent thrombotic stroke, in a patient, comprising administering to the patient a therapeutically effective amount of an antiplatelet agent in combination with a therapeutically effective amount of a COX-2 inhibitor. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a COX-2 inhibitor, or a pharmaceutically acceptable salt thereof, and an antiplatelet agent, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 12, 1999Date of Patent: October 24, 2000Assignee: Merck & Co., Inc.Inventor: Steven A. Nichtberger
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Patent number: 6084065Abstract: The present invention relates to oligopeptidic compounds having the general formula (I):K--[--A--].sub.z --[--B--].sub.w --L (I)The compounds having general formula (I) are antifungals for agricultural purposes.Type: GrantFiled: October 4, 1994Date of Patent: July 4, 2000Assignee: Isagro SpaInventors: Giovanni Camaggi, Lucio Filippini, Marilena Gusmeroli, Carlo Garavaglia, Ernesto Signorini
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Patent number: 6080771Abstract: DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided: ##STR1## wherein R.sup.1 represents CO(CR.sup.4A R.sup.4B).sub.n1 (O(CH.sub.2).sub.p1).sub.n2 OR.sup.5 {wherein n1 represents an integer of 1 or 2; R.sup.4A and R.sup.4B are the same or different, and each represents hydrogen or lower alkyl; p1 and n2 each represents an integer of 1 to 10; and R.sup.Type: GrantFiled: August 13, 1998Date of Patent: June 27, 2000Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yutaka Kanda, Hitoshi Arai, Hiroyuki Yamaguchi, Tadashi Ashizawa, Shun-ichi Ikeda, Chikara Murakata, Tatsuya Tamaoki
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Patent number: 6020006Abstract: Mammalian hair growth is reduced by applying to the skin an inhibitor of alkaline phosphatase.Type: GrantFiled: October 27, 1998Date of Patent: February 1, 2000Assignee: The Gillette CompanyInventors: Peter Styczynski, Gurpreet S. Ahluwalia
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Patent number: 5994380Abstract: This invention refers to new analogs of strobilurine, having the general formula (I): ##STR1## The compounds of formula (I) are endowed with good stability and high fungicidal activity against phytopathogenous fungi, combined with good selectivity for the vegetable it is designed to apply to.Type: GrantFiled: October 19, 1998Date of Patent: November 30, 1999Assignee: Isagro Ricerca S.r.L.Inventors: Lucio Filippini, Isabella Venturini, Laura Colombo, Luigi Mirenna
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Patent number: 5981547Abstract: A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3;(b) X is selected from the group consisting of O, S, SO, or SO.sub.2 ;(c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from about 3 to about 7 atoms;(d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; and(e) Het is a heteroaryl group comprising one or more rings each ring containing from about 5 to about 6 atoms other than hydrogen and wherein the group contains at least one heteroatom selected from O, N, or S.pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.Type: GrantFiled: April 9, 1998Date of Patent: November 9, 1999Assignee: The Procter & Gamble CompanyInventors: Laurence Ichih Wu, John Michael Janusz
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Patent number: 5972957Abstract: A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3;(b) X is selected from the group consisting of O, S, SO, or SO.sub.2 ;(c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from about 3 to about 7 atoms;(d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; and(e) Het is a heteroaryl group comprising one or more rings each ring containing from about 5 to about 6 atoms other than hydrogen and wherein the group contains at least one heteroatom selected from O, N, or S.Pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pair using such compounds.Type: GrantFiled: April 9, 1998Date of Patent: October 26, 1999Assignee: The Procter & Gamble CompanyInventors: Laurence Ichih Wu, John Michael Janusz
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Patent number: 5952385Abstract: This invention is directed to a pharmacologically acceptable composition for inhibiting nitric oxide synthase in a mammal, which includes a mercapto derivative and a pharmaceutically acceptable carrier. The invention also concerns a method of inhibiting nitric oxide synthase, selectively inhibiting the inducible isoform of nitric oxide synthase, and treating various conditions where there is an advantage in inhibiting nitric oxide biosynthesis. The method includes the step of administering to a mammal a mercapto derivative in pure form or in a pharmaceutically acceptable carrier.Type: GrantFiled: July 8, 1997Date of Patent: September 14, 1999Assignee: Children's Hospital Medical CenterInventors: Garry J. Southan, Andrew L. Salzman, Csaba Szabo
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Patent number: 5948630Abstract: A composition and method are disclosed to reduce the effects that endogenous alkaline phosphatase found in some human bodily fluid samples have on solid phase immunoassay systems. The composition comprises a detergent, inhibitors to alkaline phosphatase, and a buffer and may contain a substrate to alkaline phosphatase.Type: GrantFiled: August 5, 1996Date of Patent: September 7, 1999Assignee: Dade Behring Inc.Inventors: Pratap Singh, Randy W. Johnson
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Patent number: 5942535Abstract: The present invention relates to heterocyclic compounds of the formula ##STR1## in which R.sup.1 -R.sup.7, B, a and X have the meanings recited in the specification. These compounds are usable in the treatment of diseases of the rheumatoid group and for the prevention of allergically induced diseases.Type: GrantFiled: March 28, 1997Date of Patent: August 24, 1999Assignee: Merckle GmbHInventors: Stefan Laufer, Hans Gunther Striegel, Gerd Dannhardt
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Patent number: 5939415Abstract: The present invention relates to heterocyclic compounds with the formula ##STR1## in which R.sup.1 to R.sup.7, B, a, and X have the meanings indicated in the specification. These compounds can be used for the treatment of diseases of the rheumatic variety and for the prevention of allergically-induced diseases.Type: GrantFiled: March 28, 1997Date of Patent: August 17, 1999Assignee: Merckle GmbHInventors: Stefan Laufer, Hans Gunther Striegel, Gerd Dannhardt
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Patent number: 5872141Abstract: The present invention is directed to a method of inhibiting cholesterol transport through the intestinal lumen of a subject. The method comprises administering an intestinal alkaline phosphatase inhibitor to the subject. The inhibition of intestinal alkaline phosphatase prevents transport of exogenous cholesterol through the intestinal lumen and therefore decreases plasma levels of cholesterol. The invention further provides a method of screening for agents which inhibit cholesterol transport. This method comprises expressing intestinal alkaline phosphatase in a host cell, exposing the host cell to an agent and cholesterol, and determining whether the cholesterol is transported into the host cell. Since intestinal alkaline phosphatase mediates cholesterol transport into the cell, an agent that inhibits the expressed intestinal alkaline phosphatase (or inhibits the expression of intestinal alkaline phosphatase), will inhibit cholesterol transport.Type: GrantFiled: February 18, 1997Date of Patent: February 16, 1999Inventors: Jay N. Umbreit, Marcel E. Conrad
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Patent number: 5869492Abstract: Compounds of formula I ##STR1## in which A is S(O).sub.p or O;p is 0, 1 or 2;g is 0, 1, 2, 3, or 4;n is 2 or 3; andR.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are optional substituents have utility in the treatment of central nervous system disorders, for example depression, anxiety, psychoses (for example schizophrenia), tardive dyskinesia, obesity, drug addiction, drug abuse, cognitive disorders, Alzheimer's disease, senile dementia, cerebral ischemia, obsessive-compulsive behavior, panic attacks, social phobias, eating disorders and anorexia, non-insulin dependent diabetes mellitus, hyperglycemia, and stress.Type: GrantFiled: December 15, 1997Date of Patent: February 9, 1999Assignee: Knoll AktiengesellschaftInventors: Frank Kerrigan, Sharon Crawford Cheetham, Roy Victor Davies
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Patent number: 5716974Abstract: Compounds based on heterobicyclic derivatives, of general formula (I): ##STR1## possessing fungicidal activity.Type: GrantFiled: January 6, 1997Date of Patent: February 10, 1998Assignee: Isagro S.p.A.Inventors: Giovanni Camaggi, Lucio Filippini, Marilena Gusmeroli, Silvia Mormile, Isabella Venturini, Carlo Garavaglia, Ernesto Signorini
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Patent number: 5714142Abstract: Compositions and methods are provided for increasing the serum half-life of a pharmacologically active agent. The novel compositions are covalent conjugates of the selected pharmacologically active agent and a transthyretin-binding ligand such as tetraiiodothyroacetic acid, 2,4,6-triiodophenol, flufenamic acid, or the like.Type: GrantFiled: June 13, 1996Date of Patent: February 3, 1998Inventors: Jeffrey M. Blaney, Fred Cohen
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Patent number: 5674907Abstract: This invention is directed to a pharmacologically acceptable composition for inhibiting nitric oxide synthase in a mammal, which includes a mercapto derivative and a pharmaceutically acceptable carrier. The invention also concerns a method of inhibiting nitric oxide synthase, selectively inhibiting the inducible isoform of nitric oxide synthase, and treating various conditions where there is an advantage in inhibiting nitric oxide biosynthesis. The method includes the step of administering to a mammal a mercapto derivative in pure form or in a pharmaceutically acceptable carrier.Type: GrantFiled: March 24, 1995Date of Patent: October 7, 1997Assignee: Children's Hospital Medical CenterInventors: Garry J. Southan, Andrew L. Salzman, Csaba Szabo
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Patent number: 5599813Abstract: Thiazolopyrimidine derivatives represented by the formula ##STR1## and salts thereof are provided, which are characterized by a carboxamide residue substituted with R.sup.4 and R.sup.5. The derivatives and salts thereof exhibit antiangiogenic activity and are useful for treatment and cure of diseases, the development of which may be related to angiogenesis, including diabetic retinopathy, various chronic inflammation conditions, growth or metastasis of malignant solid tumors, rheumatism and psoriasis.Type: GrantFiled: April 1, 1994Date of Patent: February 4, 1997Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Hiroo Matsumoto, Noriko Tanaka, Kiyoshi Nakayama, Haruko Chatani, Michio Iwahana
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Patent number: 5567716Abstract: Traumatic acid salts, wherein B is a cation selected from:a) a quaternary ammonium,b) a cation of a linear or branched C.sub.1 -C.sub.20 mono-, di- or trialkanolamine,c) a cation of a biologically active primary, secondary or tertiary amine,d) silver or zinc cation,and relative pharmaceutical compositions administrable by topical or parenteral route For the therapeutic treatment of cutaneous pathologies in which it is important to associate an a bacteriostatic, antibiotic, antifungal or an antiviral activity, to the cicatrizant effect, typical of traumatic acid.Type: GrantFiled: November 19, 1993Date of Patent: October 22, 1996Assignee: Lifegroup S.p.A.Inventors: Francesco Della Valle, Silvana Lorenzi, Gabriele Marcolongo
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Patent number: 5567724Abstract: The present invention provides a method of inhibiting .beta.-amyloid toxicity in brain cells. The method includes administering to the cells an amount of an alkaline phosphatase inhibitor which is pharmacologically effective to reduce degeneration in the cells. Methods of treatment of peripheral neuropathy are also provided using acid or alkaline phosphatase inhibitors.Type: GrantFiled: June 1, 1994Date of Patent: October 22, 1996Assignee: Cortex Pharmaceuticals, Inc.Inventors: Judith A. Kelleher, David D. Eveleth
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Patent number: 5559136Abstract: The present invention relates to therapeutically active azacyclic compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.Type: GrantFiled: May 30, 1995Date of Patent: September 24, 1996Assignee: Novo Nordisk A/SInventors: Per Sauerberg, Preben H. Olesen, Charles H. Mitch
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Patent number: 5552422Abstract: The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.Type: GrantFiled: January 11, 1995Date of Patent: September 3, 1996Assignee: Merck Frosst Canada, Inc.Inventors: Jacques Y. Gauthier, Cheuk K. Lau, Yves LeBlanc, Chun-Sing Li, Patrick Roy, Michel Therien, Zhaoyin Wang
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Patent number: 5540931Abstract: The present invention provides methods and formulations for site-specific immune suppression of immune/inflammatory responses with localized or topical application of immunosuppressants including cyclosporines, rapamycins (RPM), or combinations of immunosuppressants and anti-inflammatory compounds. Methods for the use of said formulations to effect site-specific immune suppression of local inflammatory/immune responses in mammalian tissue and for treatment of autoimmune, T-cell mediated immune disease, inflammatory conditions, inhibition of contact hypersensitivity, and for producing prolonged skin allograft survival, and wound healing are presented. In addition, methods for use of said formulations--in tandem with systemic applications of immunosuppressant such as cyclosporine or without same--are presented. The present invention also relates to alternative formulations and delivery systems for the efficacious treatment of the aforementioned conditions.Type: GrantFiled: June 24, 1994Date of Patent: July 30, 1996Assignees: Charles W. Hewitt, Kirby S. BlackInventors: Charles W. Hewitt, Kirby S. Black
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Patent number: 5516647Abstract: The present invention discloses novel compounds useful as alkaline phosphatase inhibitors and therapeutic agents. Preferably, the novel compounds are useful as selective inhibitors of human alkaline phosphatases as opposed to Escherichia coli alkaline phosphatases. The novel compounds can also be used as cancer therapeutic agents, anti-depressive agents, anti-anergic agents, and antihelminthic agents. The novel compounds have the following general formula: ##STR1## wherein R' is an aryl, aryl ether, aryl thioether, aromatic heterocyclic, aromatic heterocyclic thioether, or aromatic heterocyclic ether group. More preferably, R' is a phenyl or a pyridine. Most preferably, R' is of the following formula: ##STR2## 2-thiopyridine, or ##STR3## 2-oxypyridine. R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.1 ', R.sub.2 ', R.sub.3 ', R.sub.4 ', and R.sub.5 ' can be the same or different, and at least one of which is selected from the group consisting of: H, C.sub.1 -C.sub.6 alkyl, halo C.sub.1 -C.sub.6 alkyl, phenyl, C.Type: GrantFiled: November 5, 1993Date of Patent: May 14, 1996Assignee: Abbott LaboratoriesInventors: Mazhar Husain, Dominique Bridon, Mark Bures, James D. Ratajczyk, Fortuna Haviv, Christopher Bieniarz
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Patent number: 5512587Abstract: A method is disclosed for treating opiate-addicted individuals to attentuate the withdrawal syndrome comprising administering the compound levamisole in a suitable pharmaceutical carrier.Type: GrantFiled: December 19, 1994Date of Patent: April 30, 1996Inventor: Sydney Spector
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Patent number: 5504089Abstract: Compounds of formula I ##STR1## wherein R.sup.1 -R.sup.4, X, Y, and Z have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful as potassium channel openers for the treatment of urinary incontinence. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.Type: GrantFiled: May 13, 1994Date of Patent: April 2, 1996Assignee: Zeneca LimitedInventor: Keith Russell
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Patent number: RE36375Abstract: The present invention relates to therapeutically active azacyclic compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.Type: GrantFiled: February 18, 1998Date of Patent: November 2, 1999Assignee: Novo Nordisk A/SInventors: Per Sauerberg, Preben H. Olesen, Charles H. Mitch