Divalent Chalcogen Or Acyclic Nitrogen Double Bonded Directly At Both 2- And 4- Positions, Or Tautomeric Equivalent (e.g., Hydantoin, Etc.) Patents (Class 514/389)
-
Patent number: 6565868Abstract: Microbiological control in water systems is achieved with an amount,of 1,3-dibromo-5,5-dimethylhydantoin that is less than the amount of N,N′-bromochloro-5,5-dimethylhydantoin required to achieve the same degree of microbiological control. The methods of combating Escherichia coli and/or Enterococcus faecium in an aqueous medium, and biofilms such as formed by Pseudomonas aeruginosa on surfaces contacted by the aqueous medium, involve introducing into the medium a biocidally effective amount of 1,3-dibromo-5,5-dimethylhydantoin. A microbiological control agent for use in water in accordance with U.S. Environmental Protection Agency regulations is purveyed in containers of a water control agent comprising 1,3-dibromo-5,5-dimethylhydantoin, which containers bear a label having thereon dosage levels pursuant to requirements promulgated by the U.S. Environmental Protection Agency. The 1,3-dibromo-5,5-dimethylhydantoin is used or purveyed either as a product having a large average particle size (e.g.Type: GrantFiled: January 18, 2000Date of Patent: May 20, 2003Assignee: Albemarle CorporationInventors: Jonathan N. Howarth, Christopher J. Nalepa, Michael J. Sanders, David L. Shelton
-
Patent number: 6562853Abstract: The present invention provides ester compounds, methods of controlling a pest and uses of the ester compounds. The ester compounds are encompassed by formula (1): wherein R represents a C1 to C3 alkyl group. The methods of controlling a pest entail applying the ester compound encompassed by formula (1) to a pest or to a habitat of the pest or both. The uses of the ester compounds encompassed by formula (1) are for controlling pests.Type: GrantFiled: February 20, 2002Date of Patent: May 13, 2003Assignee: Sumitomo Chemical Company, LimitedInventors: Tatsuya Mori, Tomonori Iwasaki
-
Publication number: 20030083360Abstract: A process for the roller compaction and manufacture of a pharmaceutical formulation comprises the steps of adding sodium phenytoin to a vessel of a blender and adding at least one excipient to the vessel. The mixture is blended and transferred to a roller compactor, where pressure is applied to the blend of sodium phenytoin and excipient. Next, the resultant compaction is milled to form a granulation, which is blended a second time and is suitable for further processing into a dosage form. Preferably, the excipients include magnesium stearate, sugar, lactose monohydrate, and talc. In an alternative embodiment, talc is added immediately prior to the granulation being blended for a second time.Type: ApplicationFiled: May 14, 2002Publication date: May 1, 2003Inventors: George Crotts, Mebrahtu G. Fessehaie, Srinivas Raju Gadiraju, John Gawel, Isaac Ghebre-Sellassie, Ashlesh K. Sheth
-
Publication number: 20030073723Abstract: The present invention relates to novel imidazolidine derivatives of formula I, 1Type: ApplicationFiled: March 8, 2002Publication date: April 17, 2003Inventors: Volkmar Wehner, Horst Blum, Hartmut Rutten, Hans Ulrich Stilz
-
Patent number: 6531499Abstract: Peptoid compounds of Formula I and Formula II are disclosed The compounds are useful in the treatment of matrix metalloproteinase-mediated disorders.Type: GrantFiled: July 23, 2001Date of Patent: March 11, 2003Assignee: Wisconsin Alumni Research FoundationInventors: Donald T. Witiak, Paul J. Bertics, Yingsheng Zhang
-
Publication number: 20030044434Abstract: The present invention provides a novel pharmaceutical composition based on the use of a particular oil phase which comprises a lipophilic, pharmaceutically active agent, a mixture of diglyceride and monoglyceride in a ratio of from about 9:1 to about 6:4 by weight (diglyceride:monoglyceride) wherein the diglyceride and monoglyceride are mono- or di-unsaturated fatty acid esters of glycerol having sixteen to twenty-two carbon chain length, one or more pharmaceutically acceptable solvents, and one or more pharmaceutically acceptable surfactants. The composition is in a form of self-emulsifying formulation which provides high concentration and high oral bioavailability for lipophilic compounds.Type: ApplicationFiled: August 21, 2002Publication date: March 6, 2003Inventors: Ping Gao, Walter Morozowich
-
Patent number: 6521654Abstract: Substituted imidazolidine derivatives of the formula I, in which B, E, W, Y, R, R2, R3, R30, e and h have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds, which are suitable, for example, for the therapy and prophylaxis of inflammatory disorders, for example of rheumatoid arthritis, or of allergic disorders. The compounds of the formula I are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 belonging to the integrins group. They are generally suitable for the therapy or prophylaxis of illnesses which are caused by an undesired extent of leucocyte adhesion and/or leucocyte migration or are associated therewith, or in which cell-cell or cell-matrix interactions which are based on interactions of VLA-4 receptors with their ligands play a part.Type: GrantFiled: September 14, 2001Date of Patent: February 18, 2003Assignee: Aventis Pharma Deutschland GmbHInventors: Volkmar Wehner, Hans Ulrich Stilz, Wolfgang Schmidt, Dirk Seiffge
-
Patent number: 6508954Abstract: Among the enhanced properties of the 1,3-dibromo-5,5-dimethylhydantoins described are their larger average particle sizes, their compactibility even though devoid of a binder, their excellent free-flowing and low-dust properties, and their more appealing aesthetic qualities, as compared to previously known 1,3-dibromo-5,5-dimethylhydantoins. These novel 1,3-dibromo-5,5-dimethylhydantoins can be produced, for example, by concurrently feeding (i) an aqueous solution or slurry formed from an inorganic base and 5,5-dimethylhydantoin, and (ii) a brominating agent, in proportions such that each nitrogen atom is substituted by a bromine atom, thereby forming product which precipitates in an aqueous reaction mixture. The pH of the reaction mixture is maintained in the range of about 5.5 to about 8.5.Type: GrantFiled: January 18, 2000Date of Patent: January 21, 2003Assignee: Albemarle CorporationInventors: Hassan Y. Elnagar, Jonathan N. Howarth, Bruce C. Peters, Edgar E. Spielman, Jr., Dustin H. Thomas
-
Publication number: 20020192293Abstract: A process for the dry granulation and manufacture of a pharmaceutical formulation comprises the steps of adding sodium phenytoin to a vessel of a mixer/granulator and adding at least one excipient to the vessel. Heat is then applied from the vessel to the sodium phenytoin and excipient to achieve the desired target temperature. Next, while the heat is applied from the vessel, the sodium phenytoin and excipient are mixed and chopped in the vessel to form a granulation suitable for encapsulating into a dosage form. Preferably, the excipients include magnesium stearate, sugar, lactose monohydrate, and talc. In an alternative embodiment, talc is added after chopping and blended into the formulation to form a blend suitable for encapsulating into a dosage form.Type: ApplicationFiled: April 5, 2002Publication date: December 19, 2002Inventors: Srinivas R. Gadiraju, Qing Ha, Agber Ifan, Sau-Hung Spence Leung, Adam Sabouni
-
Publication number: 20020183374Abstract: The present invention relates to hydantoins of formula I, 1Type: ApplicationFiled: March 8, 2002Publication date: December 5, 2002Inventors: Volkmar Wehner, Hans Ulrich Stilz, Klaus Burger, Alexander Golubev, Sergej Ossipov
-
Publication number: 20020172720Abstract: Pseudomonas aeruginosa biofilm on a surface is eradicated or at least reduced using a microbiocidally effective amount of at least one of the following bromine-based microbiocides:Type: ApplicationFiled: March 27, 2001Publication date: November 21, 2002Inventor: Christopher J. Nalepa
-
Publication number: 20020173530Abstract: The present invention pertains to single morphic forms of a compound selected from 2S-[4-(2,5-dioxopyrrolidin-1-yl)-2S-mercaptobutyrylamino]4-methylpentanoic acid (2,2-dimethyl-1S-methylcarbamoylpropyl)amide and 2S-[2S-mercapto-4-(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)butyrylamino]-4-methylpentanoic acid (2,2-dimethyl-1S-methylcarbamoylpropyl)amide, isolable as such.Type: ApplicationFiled: March 21, 2002Publication date: November 21, 2002Inventors: Ruth Bernice Katz, Graham Robert Evans
-
Patent number: 6472406Abstract: The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel &bgr;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &bgr;-lactamase inhibitors presently available, and which do not require a &bgr;-lactam pharmacophore. The invention also provides pharmaceutical compositions and methods for inhibiting bacterial growth.Type: GrantFiled: July 5, 2000Date of Patent: October 29, 2002Assignee: MethylGene, Inc.Inventors: Jeffrey M. Besterman, Daniel Delorme, Jubrail Rahil
-
Patent number: 6471974Abstract: The antimicrobial efficacy of N-chlorosulfamate solutions, namely buffered aqueous combinations of HClNSO3−(mono-N-chlorosulfamate) and Cl2NSO3 (di-N-chlorosulfamate), herein referred to as “stabilized hypochlorite”, can be markedly enhanced by the addition of certain organic dopants. The dopants themselves are select hypochlorite stabilizing agents, which are known to readily form stable organochloramides when reacted with “free” hypochlorite (HOCl or NaOCl). Highly effective antimicrobial enhancing dopants include 5,5-dialkyl hydantoins, arylsulfonamides, and succinimides. Examples of these include 5,5-dimethylhydantoin, benzenesulfonamide, and succinimide. Other, less effective dopants include glycolurils. Generally, the dopant is present in a minor mole fraction, relative to the molar amount of stabilized hypochlorite present in the enhanced antimicrobial solution.Type: GrantFiled: June 29, 1999Date of Patent: October 29, 2002Assignee: S.C. Johnson & Son, Inc.Inventors: Wayne M. Rees, Debra S. Hilgers
-
Publication number: 20020147228Abstract: A highly safe and useful therapeutic agent for hypoalbuminaemia contains a hydantoin derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof as an effective ingredient: 1Type: ApplicationFiled: February 12, 2002Publication date: October 10, 2002Inventors: Kazuharu Ienaga, Hiroki Mikami, Ryoji Nishibata
-
Publication number: 20020147194Abstract: The present invention relates to compounds of the formula 1Type: ApplicationFiled: March 6, 2002Publication date: October 10, 2002Applicant: Pfizer Inc.Inventor: Harry Ralph Howard
-
Patent number: 6462063Abstract: The present invention relates to a novel class of N,N′-di substituted hydantoin hydroxamates capable of inhibiting C-proteinase, and to their use to regulate, modulate and/or inhibit abnormal collagen formation as a therapeutic approach towards the treatment of fibrotic disorders.Type: GrantFiled: February 4, 2000Date of Patent: October 8, 2002Assignee: Fibrogen, Inc.Inventors: Wen-Bin Ho, Udo Bauer
-
Patent number: 6451831Abstract: A highly safe and useful therapeutic agent for hypoalbuminaemia contains a hydantoin derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof as an effective ingredient: wherein each of R1 and R2, which may be the same or different, represents hydrogen, an alkyl group or a cycloalkyl group; and each of X and Y, which may be the same or different, represents hydrogen, a hydroxyl group, an alkyl group or an alkoxy group, or X and Y together represent an oxo group. Administration of the compounds substantially increases the serum albumin value of patients suffering from hypoalbuminaemia from abnormal values, and significantly improves the condition of hypoalbuminaemia.Type: GrantFiled: February 12, 2002Date of Patent: September 17, 2002Assignee: Nippon Zoki Pharmaceutical Co., Ltd.Inventors: Kazuharu Ienaga, Hiroki Mikami, Ryoji Nishibata
-
Publication number: 20020123502Abstract: The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.Type: ApplicationFiled: December 26, 2001Publication date: September 5, 2002Applicant: DR. REDDY'S RESEARCH FOUNDATION & REDDY-CHEMINOR, INC.Inventors: Vidya Bhushan Lohray, Braj Bhushan Lohray, Rao Bheema Paraselli, Ranga Madhavan Gurram, Rajagopalan Ramanujam, Ranjan Chakrabarti, Sarma K.S. Pakala
-
Publication number: 20020120000Abstract: Microbiological control is achieved by continuously and inexpensively dosing water in contact with biofilm, or that comes into contact with biofilm, using a highly effective biocide that provides very effective microbiocidal control of planktonic microorganisms and of biofilm species, even where the biofilm infestations have been in existence for long periods of time and thus have encased themselves in a substantial quantity of slimy defensive polysaccharide layers or films. In addition, the biocide used makes possible significant reduction in copper and/or iron surfaces in contact with the water as compared to N,N′-bromochloro-5,5-dimethyl hydantoin. Still other advantages are made possible by the described technology.Type: ApplicationFiled: October 9, 2001Publication date: August 29, 2002Inventors: Jonathan N. Howarth, Christopher J. Nalepa, Michael J. Sanders, David L. Shelton
-
Patent number: 6420408Abstract: Tricyclic sulfonamide compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurysm, heart failure, left ventricular dilation, restenosis, periodontal disease, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.Type: GrantFiled: April 10, 2001Date of Patent: July 16, 2002Assignee: Warner-Lambert CompanyInventors: Patrick Michael O'Brien, Joseph Armand Picard, Drago Robert Sliskovic
-
Patent number: 6417219Abstract: The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to Formula (I). Also disclosed are compounds, pharmaceutical compositions and methods of treating diseases characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.Type: GrantFiled: August 26, 1997Date of Patent: July 9, 2002Assignee: The Proctor & Gamble CompanyInventors: Michael George Natchus, Biswanath De, Stanislaw Pikul, Neil Gregory Almstead, Roger Gunnard Bookland, Yetunde Olabisi Taiwo, Menyan Cheng
-
Publication number: 20020082252Abstract: The present invention relates to methods and compositions for treating selected conditions of the central and peripheral nervous systems employing non-synaptic mechanisms. More specifically, one aspect of the present invention relates to methods and materials for treating seizure and seizure disorders, epilepsy, status epilepticus, migraine, spreading depression, intracranial hypertension; for treating the pathophysiological effects of head trauma, stroke, ischemia and hypoxia; for treating or protecting from the pathophysiological effects of neurotoxic agents such as ethanol; and for treating neurophsyciatric disorders and central nervous system edema by administering agents that modulate ionic concentrations and/or ionic gradients in the brain, particularly ion-dependent or cation-chloride cotransporter antagonists. Electrolyte cotransport antagonists and combinations of such compositions with other agents for treating various conditions are disclosed.Type: ApplicationFiled: January 23, 2002Publication date: June 27, 2002Applicant: Cytoscan Sciences L.L.C.Inventor: Daryl W. Hochman
-
Publication number: 20020077319Abstract: This invention relates to pharmaceutical compositions comprising combinations of a GABA agonist, a prodrug thereof or a pharmaceutically acceptable salt of said GABA agonist or said prodrug and an ARI, a prodrug thereof or a pharmaceutically acceptable salt of said ARI or said prodrug, kits containing such combinations and methods of using such combinations to treat mammals, including humans, suffering from diabetic complications such as diabetic neuropathy, diabetic nephropathy, diabetic cardiomyopathy, diabetic retinopathy, diabetic microangiopathy, diabetic macroangiopathy, cataracts or foot ulcers.Type: ApplicationFiled: November 29, 2001Publication date: June 20, 2002Inventor: Banavara L. Mylari
-
Publication number: 20020058685Abstract: The present invention relates generally to novel hydantoin derivative compounds, pharmaceutical compositions containing such compounds, and methods for their use in preventing and/or treating neurological disorders, including physically damaged nerves and neurodegenerative diseases; for treating alopecia and promoting hair growth; for treating vision disorders and/or improving vision; for treating memory impairment and/or enhancing memory performance; and for treating sensorineural hearing loss by administering such compounds.Type: ApplicationFiled: December 21, 2000Publication date: May 16, 2002Inventor: Gregory S. Hamilton
-
Patent number: 6384061Abstract: The present invention relates to novel hydantoin compounds represented by formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an anti-cancer agent, or pharmaceutically acceptable salts thereof, in which R1, R2, R3 and R4 are as defined in the present application. The present invention also relates to a process for preparation of the compound of formula (I), and to an anti-cancer composition comprising the compound of formula (I) as an active ingredient.Type: GrantFiled: March 30, 2000Date of Patent: May 7, 2002Assignee: LG Chemical Ltd.Inventors: Jin Ho Lee, Jong Sung Koh, Jong Hyun Kim, Hyun Il Lee, Won Hee Jung, Seong Gu Ro, You Seong Shin, Sang Woong Kim, Ki Won Park, Tae Hwan Kwak, Kyung Duk Moon, Hyun Ho Chung
-
Patent number: 6380233Abstract: Compounds of the formula where W is n is 0, 1, or 2; m is 0, 1, 2, or 3: Y and G are each independently oxygen or sulfur; Z is —O—, —S—, —NH, or —CH2; R1 is hydrogen, C1 to C8 alkyl, substituted C1 to C8 alkyl substituted with one hydroxy, C3 to C8 alkenyl, C3 to C8 alkynyl, aryl, C1 to C3 alkylaryl, C1 to C3 alkylheteroaryl, or —Q—R4; R2 and R3 are each independently hydrogen, C1 to C6 alkyl, aryl, C1 to C3 alkylaryl, or C1 to C3 alkylheteroaryl; R4 is cyano, trifluoromethyl, —COR8, —CO2R8, —CONR8R10, —OR9, —SO2NR9R10, or —S(O)4R8; R8 and R10 are each independently hydrogen, C1 to C8 alkyl, C1 to C3 alkylaryl, aryl, or R9 and R10 may together be taken to form a three- to seven-membered alkyl ring or a three- to seven-membered heteroalkyl ring having 1 heteroatom of O; Q is C1 to C3 alkyl; R11 is hydrogen, —OR12, or —NHCOR12; R12 is hydrogen, C1 to C6 alkyl, aryl, or C1 to C3 alkType: GrantFiled: October 23, 2000Date of Patent: April 30, 2002Assignee: Pfizer IncInventors: John Eugene Macor, Martin James Wythes
-
Patent number: 6365607Abstract: A medicinal composition for the prophylaxis and treatment of cachexia which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula —CO—, —CH(OH)—, or —NR3— (R3 represents an alkyl group that may be substituted); m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R1 represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R1; L and M respectively represent hydrogen or may be combined with each other to form a bond, provided that when m and n are 0, X represents CH, A represents a bond, Q represents sulfur, R1, L and M respectively represent hydrogen, and ring E does not have further substituents, R does not represent dihydrobenzopyranyl; orType: GrantFiled: June 28, 2000Date of Patent: April 2, 2002Assignee: Takeda Chemical Industries, Ltd.Inventors: Yu Momose, Etsuya Matsutani, Takashi Sohda
-
Publication number: 20020032222Abstract: This invention provides compounds of Formula I having the structure 1Type: ApplicationFiled: July 12, 2001Publication date: March 14, 2002Applicant: American Home Products CorporationInventors: Michael S. Malamas, Elwood E. Largis, Iwan Gunawan, Zenan Li
-
Patent number: 6355664Abstract: A method treating or preventing inflammatory and immune cell-mediated diseases by the administration of certain novel and known small molecules.Type: GrantFiled: August 16, 1999Date of Patent: March 12, 2002Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Terence A. Kelly, Barbara Jean Bormann, Leah Lynn Frye, Jiang-Ping Wu
-
Patent number: 6353013Abstract: Novel compounds of the formula I which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are: 5-(R)-(4-bromobenzyl)-3-(3-chloro-5-nitrophenyl)-5-methylimidazoline-2,4-dione; and, 5-(R)-(4-bromobenzyl)-3-(3-chloro-5-cyanophenyl)-5-methylimidazoline-2,4-dione.Type: GrantFiled: June 28, 2000Date of Patent: March 5, 2002Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Terence Alfred Kelly, Ronald John Sorcek
-
Patent number: 6353021Abstract: This invention is directed to a stabilized biocidal composition which comprises a mixture of at least one halopropynyl compound, and particularly a halopropynyl carbamate fungicide such as IPBC, a UV absorber and an organic epoxide.Type: GrantFiled: May 8, 2000Date of Patent: March 5, 2002Assignee: Troy Technology Corporation, Inc.Inventors: Kamlesh Gaglani, Meihua Yang
-
Publication number: 20020025975Abstract: Novel diphenylethylene compounds containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. In contrast to previously reported thiazolidinedione compounds, known to lower leptin levels, the present compounds increase leptin levels and have no known liver toxicity. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.Type: ApplicationFiled: February 20, 2001Publication date: February 28, 2002Inventors: Bishwajit Nag, Debendranath Dey, Satyanarayana Medicherla, Partha Neogi
-
Patent number: 6331633Abstract: Novel diphenylethylene compounds containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. In contrast to previously reported thiazolidine compounds, known to lower leptin levels, the present compound increase leptin levels and have no known liver toxicity.Type: GrantFiled: April 6, 1999Date of Patent: December 18, 2001Assignee: Calyx Therapeutics Inc.Inventors: Partha Neogi, Bishwajit Nag, Satyanarayana Medicherla, Debendranath Dey
-
Publication number: 20010051637Abstract: A method for the prophylaxis or treatment of conditions for which 5-HT1-like agonists are indicated comprising the administration of therapeutically-effective amount of compounds of formula (I) 1Type: ApplicationFiled: January 12, 2001Publication date: December 13, 2001Inventors: Robert John Blade, Yih Sang Pang, David Lawrence Selwood
-
Patent number: 6319949Abstract: A method for preventing fungal diseases in crops which comprises the steps of: (a) applying to a crop an aqueous or a non-aqueous spray composition which includes a pesticide and a spray adjuvant including a solvent and an emulsifier, wherein the solvent is a mixture of aliphatic hydrocarbons having a distillation range of about 520 to 600° F. and an aromatic content of about 1% or less, or the solvent is a single or combination of C6-C18 fatty alcohol(s); and (b) applying chlorothalonil to the crop previously to, simultaneously with, or subsequently to the application of the aqueous spray composition, wherein phytotoxicity associated with the application of chlorothalonil is reduced or eliminated.Type: GrantFiled: November 4, 1996Date of Patent: November 20, 2001Assignee: Syngenta LimitedInventors: Jeffrey R. Schussler, Robert E. Moser, Kevin E. Crosby, John R. Washington
-
Patent number: 6313146Abstract: The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.Type: GrantFiled: June 7, 1995Date of Patent: November 6, 2001Assignee: NPS Pharmaceuticals, Inc.Inventors: Bradford C. Van Wagenen, Manuel F. Balandrin, Eric G. DelMar, Edward F. Nemeth
-
Publication number: 20010036440Abstract: Mammalian subjects may be phenotyped as poor or extensive metabolizers with respect to CYP2C19 by measuring the ratio of R and S mephenytoin or S-mephenytoin to S-4-hydroxymephenytoin produced from racemic mephenytoin in urine, saliva or plasma samples.Type: ApplicationFiled: March 26, 2001Publication date: November 1, 2001Inventors: Hylar L. Friedman, AjitKumar K. Shah
-
Patent number: 6294573Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.Type: GrantFiled: January 27, 2000Date of Patent: September 25, 2001Assignee: Abbott LaboratoriesInventors: Michael L. Curtin, Yujia Dai, Steven K. Davidsen, Joseph F. Dellaria, Jr., Alan S. Florjancic, Jianchun Gong, Yan Guo, Howard R. Heyman, James H. Holms, Michael R. Michaelides, Jamie R. Stacey, Douglas H. Steinman, Carol K. Wada, Lianhong Xu
-
Patent number: 6288071Abstract: Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in plant protection.Type: GrantFiled: December 10, 1998Date of Patent: September 11, 2001Assignee: Bayer AktiengesellschaftInventors: Henry Szczepanski, Martin Zeller, Ottmar Franz Hüter
-
Patent number: 6277987Abstract: Compounds of formula wherein W is —OH or —NHOH; X is a heterocycle with the proviso that when X is a nitrogen containing heterocycle, the heterocycle is attached to the (CH2)m moiety by a ring nitrogen, —CONR2R3, —NR1COR2, —NR1SO2R2, —NR1CONR2R3, —NR1COOR4, heteroarylthio, alkylthio, arylalkylthio, heteroarylalkylthio, heterocycloalkylalkylthio, heterocycloalkylthio or arylthio; Y is carbon, nitrogen, oxygen or sulfur, provided that when Y is carbon, n is 2; Z is alkyl, aryl, alkoxy, aryloxy, aralkoxyaryl, aralkoxyheteroaryl, heteroaryl, heterocycloalkyl, heteroaryloxy, —CONR2R3, —NR1COR2, —NR1CONR2R3, —OCONR2R3, —NR1COOR4, or —SO2R2; R1 is hydrogen, alkyl, heterocycloalkylalkyl, aralkyl or heteroarylalkyl; R2 and R3 are independently R1, aryl or heteroaryl; or R2 and R3 taken together with the nitrogen atom to which they are attached form a 5- to 7-membered ring, which may optionally contain another heteroatType: GrantFiled: February 3, 1999Date of Patent: August 21, 2001Assignee: Novartis AGInventors: Paivi Jaana Kukkola, Leslie Anne Robinson, Motowo Nakajima, Junichi Sakaki
-
Patent number: 6255331Abstract: Disclosed are biocidal compositions comprising mixtures of formaldehyde-releasing imidazolidines, such as 1,3-dimethylol-5,3-dimethylhydantoin, and 3-isothiazolones stabilized with low levels of copper salts.Type: GrantFiled: August 16, 2000Date of Patent: July 3, 2001Assignee: Rohm and Haas CompanyInventors: Beverly Jean El A'mma, Susan Lynn Nagahashi
-
Patent number: 6218416Abstract: Provided are compositions typically including 1-methyl-2-nitro-3-[(3-tetrahydrofuryl)methyl]guanidine and [2,5-dioxo-3-(2-propynyl)-1-imidazolidinyl]methyl chrysanthemate, as well as a method of controlling pests.Type: GrantFiled: April 20, 2000Date of Patent: April 17, 2001Assignee: Sumitomo Chemical Company, LimitedInventor: Satoshi Sembo
-
Patent number: 6218389Abstract: The invention provides compounds of formula as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.Type: GrantFiled: July 31, 1998Date of Patent: April 17, 2001Assignee: The Procter & Gamble Co.Inventors: Neil Gregory Almstead, Roger Gunnard Bookland, Yetunde Olabisi Taiwo, Rimma Sandler Bradley, Rodney Dean Bush, Biswanath De, Michael George Natchus, Stanislaw Pikul
-
Patent number: 6218415Abstract: Novel inhibitors of bone reabsorption and antagonists of vitronectin receptors The present invention relates to 5-membered ring heterocycles of the formula I, in which E, F, G, W, Y and Z have the meaning given in the patent claims, to their preparation and to their use as medicaments. The novel compounds are used as vitronectin receptor antagonists and as inhibitors of bone reabsorption.Type: GrantFiled: March 20, 1997Date of Patent: April 17, 2001Assignees: Hoechst Aktiengesellschaft, Genetech, Inc.Inventors: Volkmar Wehner, Jochen Knolle, Hans Ulrich Stilz, Denis Carniato, Jean-Francois Gourvest, Tom Gadek, Robert McDowell
-
Patent number: 6197806Abstract: Hydantoin derivatives for eliminating free radicals and active oxygen which can be easily made into pharmaceutical preparations, show little, if any side effects, and are capable of being administered by the oral route. The pharmaceutical compositions for eliminating the active oxygen and the free radicals contain at least one hydantoin derivative represented by the following formula (I): wherein each of R1 and R2, which may be the same or different, represents hydrogen, an alkyl group or a cycloalkyl group; and each of X and Y, which may be the same or different, represents hydrogen, a hydroxyl group, an alkyl group or an alkoxy group, or X and Y together represent an oxo group. The hydantoin derivatives which have an action of eliminating the active oxygen and the free radicals are, accordingly, useful as pharmaceutical agents for treating a variety of diseases in which active oxygen and free radicals are involved or play a detrimental role.Type: GrantFiled: December 18, 1996Date of Patent: March 6, 2001Assignee: Nippon Zoki Pharmaceutical Co., Ltd.Inventors: Hitoshi Endou, Kazuharu Ienaga
-
Patent number: 6191282Abstract: 5-Membered ring heterocycle of the formula I, in which D includes a COOR15, CON(CH3)R15 or CONHR15 radical and R15 includes a 6-24 member bicyclic or tricyclic radical, compositions, preparation and use as inhibitors of thrombocyte aggregation, metastasization of carcinoma cells, binding of osteoclasts to bone surfaces and for the treatment of tromboses.Type: GrantFiled: July 28, 1999Date of Patent: February 20, 2001Assignee: Hoechst Marion RousselInventors: Gerhard Zoller, Otmar Klingler, Bernd Jablonka, Melitta Just, Gerhard Breipohl, Jochen Knolle, Wolfgang Konig, Hans-Ulrich Stilz
-
Patent number: 6177453Abstract: The present invention provides for the treatment of non-insulin dependent diabetes mellitus or obesity comprising the systemic administration of a compound having the formula or a pharmacologically acceptable salt thereof, wherein each R is H or NH2, and with the proviso that at least one R group must be NH2.Type: GrantFiled: May 7, 1999Date of Patent: January 23, 2001Assignee: Pharmacia & Upjohn CompanyInventors: Scott D. Larsen, Martin D. Meglasson, Valerie A. Vaillancourt, Paul D. May
-
Patent number: 6169103Abstract: Fluorine-substituted biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, stromelysin-1, and collagenase-3, and for the treatment of atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, osteoporosis, multiple sclerosis, renal disease, and other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.Type: GrantFiled: February 24, 1999Date of Patent: January 2, 2001Assignee: Warner-LambertInventors: Claude Forsey Purchase, Jr., Bruce David Roth, Gerald Paul Schielke, Lary Craswell Walker, Andrew David White
-
Patent number: RE38132Abstract: A method treating or preventing inflammatory and immune cell-mediated diseases by the administration of certain novel and known small molecules.Type: GrantFiled: June 12, 2002Date of Patent: June 3, 2003Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Terence A. Kelly, Barbara Jean Bormann, Leah Lynn Frye, Jiang-Ping Wu