Divalent Chalcogen Or Acyclic Nitrogen Double Bonded Directly At Both 2- And 4- Positions, Or Tautomeric Equivalent (e.g., Hydantoin, Etc.) Patents (Class 514/389)
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Patent number: 6159995Abstract: Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.Type: GrantFiled: May 8, 1998Date of Patent: December 12, 2000Assignee: Aventis Pharma Deutschland GmbHInventors: Werner Thorwart, Wilfried Schwab, Manfred Schudok, Burkhard Haase, Bernhard Neises, Gunter Billen
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Patent number: 6143204Abstract: A highly stable liquid formulation having broad spectrum preservative properties which constitutes an admixture of a dialkanol-substituted DMH, an iodopropynyl compound, a stabilizer of a hydantoin, urea or derivative thereof, and a hydroxyl solvent. Preferably the constituents are dimethyloldimethylhydantoin, 3-iodo-2-propynylbutyl carbamate, dimethylhydantoin, and a glycol solvent. The preservative preferably has a total formaldehyde content of 5% and less than 0.2% of free formaldehyde. The composition is prepared by successively admixing the dialkanol-substituted dimethylhydantoin and the stabilizer, the hydroxyl solvent, and the iodopropynyl compound. Also described is a stabilized iodopropynyl compound preferably containing dimethylhydantoin as the stabilizer.Type: GrantFiled: June 19, 1998Date of Patent: November 7, 2000Assignee: Lonza Inc.Inventors: Patrick Jay Lutz, Susan Alcorn Ban, Thomas Edward Farina
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Patent number: 6133300Abstract: This invention is directed to a broad spectrum antimicrobial composition which comprises a mixture of 1,2-benzisothiazolin-3-one, or a salt thereof, (BIT) and 1,3-bis(hydroxymethyl)-5,5-dimethylhydantoin (DMH), said mixture provided in an amount to protect a substrate from attack by one or more bacterial organisms. The composition can be used broadly in industrial systems and more particularly with substrates such as paints, coatings, stucco, concrete, stone, cementaceous surfaces, wood, caulking, sealants, textiles, leather, wood, preservatives, metal working fluids, drilling muds, clay slurries, glazes, optical brightness, carpet backing, pigments and as a preservative for other aqueous and wet state products, and the like.Type: GrantFiled: October 15, 1999Date of Patent: October 17, 2000Assignee: Troy Technology Corporation, Inc.Inventors: Roger Errol Smith, Eric S. Bensaid
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Patent number: 6121302Abstract: The present invention provides a highly stable formulation having broad spectrum preservative properties. The formulation is an admixture of dialkanol-substituted dimethyhydantoin, one or more isothiazolone compounds, a hydantoin stabilizer, and a hydroxyl solvent. The formulation is highly stable in pH ranges of about 4 to 8. Preferably the active components are dimethyloldimethylhydantoin, chloromethylisothiazolone and methylisothiazolone, and the stabilizer dimethylhydantoin. The formulation has a free formaldehyde content of less than 0.2% and is beneficial for preserving various aqueous compositions, including household and industrial products, and especially personal care products, which require a less acidic pH range than in which isothiazolone is stable in the presence of cationic salts.Type: GrantFiled: May 11, 1999Date of Patent: September 19, 2000Assignee: Lonza, Inc.Inventors: Stephen Jude Rothenburger, Valerie Lynn Higbee, Patrick Jay Lutz
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Patent number: 6121303Abstract: A compound of formula I ##STR1## wherein R.sub.1 is nitro, halogeno or cyano group and R.sub.2 is a group selected from ##STR2## wherein Y and Z are independently oxygen, sulfur or NR, wherein R is hydrogen, straight or branched C.sub.1-8 alkyl, C.sub.5-7 cycloalkyl, phenylC.sub.1-8 alkyl or phenyl group and X.sub.1 and X.sub.2 are NR, where R is hydrogen, straight or branched C.sub.1-8 alkyl, C.sub.5-7 cycloalkyl, phenylC.sub.1-8 alkyl or phenyl group, or a pharmaceutically acceptable salt or ester thereof. Pharmaceutical compositions are also disclosed.Type: GrantFiled: February 23, 1999Date of Patent: September 19, 2000Assignee: Orion-yhtyma OyInventors: Reijo Backstrom, Erkki Honkanen, Inge-Britt Linden, Erkki Nissinen, Aino Pippuri, Pentti Pohto, Tapio Korkolainen
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Patent number: 6114366Abstract: The present invention relates to compositions containing a preservative system containing a two biocidal components, a first component comprising a formaldehyde donor compound, and the second component comprising one or more isothiazolone compounds, where the weight ratio of the first component to the second component ranges from about 1:1 to about 10,000:1.Type: GrantFiled: July 2, 1999Date of Patent: September 5, 2000Assignee: Lonza Inc.Inventors: Patrick J. Lutz, John Gerald Maroski
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Patent number: 6022875Abstract: Disclosed in this invention is a method of analgesic treatment comprising administering an effective analgesic amount of a substituted 2,4-imidazolidinedione compound.Type: GrantFiled: July 31, 1998Date of Patent: February 8, 2000Assignee: Gruenenthal GmbHInventors: Oswald Zimmer, Norma Selve
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Patent number: 5981492Abstract: The present invention pertains to 5-ring heterocycles of general formula (I), wherein W, Y, Z, B, D, E and R as well as b, c, d, e, f, g, and h are as indicated in the description; to methods for preparing them, and to their use as inhibitors of platelet aggregation, metastasizing of carcinomatous cells and the attachment of osteoclasts to the bone surface.Type: GrantFiled: July 19, 1996Date of Patent: November 9, 1999Assignee: Hoechst AktiengesellschaftInventors: Gerhard Zoller, Otmar Klingler, Bernd Jablonka, Melitta Just, Gerhard Breipohl, Jochen Knolle, Wolfgang Konig, Hans-Ulrich Stilz
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Patent number: 5981511Abstract: The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.Type: GrantFiled: March 5, 1997Date of Patent: November 9, 1999Assignee: G.D. Searle & Co.Inventors: Rolando E. Gapud, Timothy J. Hagen, Ann E. Hallinan, Donald W. Hansen, Jr., Robert E. Manning, Suzanne Metz, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, R. Keith Webber
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Patent number: 5981490Abstract: Dipeptide compounds have therapeutic utility, inter alia, as metalloproteinase and TNF inhibitors.Type: GrantFiled: October 4, 1996Date of Patent: November 9, 1999Assignee: Darwin Discovery, Ltd.Inventors: Andrew Douglas Baxter, John Gary Montana, David Alan Owen
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Patent number: 5977153Abstract: Stable solid forms of preservative and embalming compositions are described which can be prepared by adding a sufficient amount of a chemical or chemicals containing at least one polar group capable of forming hydrogen and Van der Waal bonds with the reactive moieties of the aldehydes and antimicrobial agents in the preservative and embalming compositions. The amount of polar chemical(s) necessary to stabilize the reactive aldehydes and antimicrobial compounds/agents is based on a molar ratio of (i) polar groups in the stabilizing chemicals to (ii) reactive groups in the active preservative ingredient of at least 0.8.Type: GrantFiled: August 18, 1997Date of Patent: November 2, 1999Inventor: Gerald W. Camiener
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Patent number: 5972983Abstract: A pest repellent comprising improthrin as an active ingredient and inert carrier has excellent effect for repelling arthropod, mollusca and annelida. It is especially useful for repelling cockroaches.Type: GrantFiled: October 27, 1998Date of Patent: October 26, 1999Assignee: Sumitomo Chemical Company LimitedInventor: Takao Ishiwatari
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Patent number: 5965594Abstract: Improved liquid antimicrobial solutions useful as preservative additives to personal care preparations, particularly cosmetic formulations and the like, are provided which comprise 1,3-dimethylol-5,5-disubstituted hydantoin, liquid aromatic alcohol, and iodoalkynyl alkyl carbamate. A preferred antimicrobial solution can be prepared by producing the 1,3,dimethylol-5,5-disubstituted hydantoin in situ in the selected liquid aromatic alcohol and then adding to the resulting solution the previously prepared iodoalkynyl alkyl carbamate. The solutions are surprisingly water dispersible and display broad spectrum antimicrobial effectiveness, particularly antifungal effectiveness, at a relatively low usage concentration in a cosmetic medium.Type: GrantFiled: March 30, 1998Date of Patent: October 12, 1999Assignee: McIntyre Group, Ltd.Inventors: Thomas G. Schoenberg, Richard J. Otterson, Dennis Abbeduto
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Patent number: 5922751Abstract: Novel compounds which are effective PDE IV inhibitors are disclosed The compounds possess similar or improved PDE IV inhibition as compared to rolipram, with improved selectivity with regard to, e.g., PDE III inhibition. Preferred compounds are 3-(3-cyclopentyloxy-4-methoxy-benzylamino)-4-hydroxymethyl pyrazole and 3-(3-cyclopentyloxy-4-methoxybenzylamino)-4-methoxymethylpyrazole.Type: GrantFiled: January 10, 1997Date of Patent: July 13, 1999Assignee: Euro-Celtique, S.A.Inventors: David John Cavalla, Mark Chasin, Lloyd J. Dolby, Richard William Frith
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Patent number: 5912261Abstract: Carboxyalkyl heterocyclic derivatives, pharmaceutically acceptable salts thereof, and therapeutic agents containing said compounds as an effective component are useful pharmaceuticals for the treatment of diabetic complications such as diabetic neuropathy, diabetic cataracts and retinopathy, diabetic nephropathy, diabetic dermopathy, and other diabetic microangiopathy. The compounds of the present invention are represented by the following general formula (A): ##STR1## The compounds of the present invention exhibit excellent inhibitory action towards aldose reductase with a high enzyme selectivity. Accordingly, they are useful as drugs for the therapy and prevention of various types of diabetic complications without substantially inhibiting aldehyde reductase.Type: GrantFiled: December 19, 1995Date of Patent: June 15, 1999Assignee: Nippon Zoki Pharmaceutical Co., Ltd.Inventors: Takayuki Kotani, Kaoru Okamoto, Yasuhiro Nagaki
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Patent number: 5889037Type: GrantFiled: June 7, 1995Date of Patent: March 30, 1999Assignee: Orion-yhtyma OyInventors: Reijo Backstrom, Erkki Honkanen, Inge-Britt Linden, Erkki Nissinen, Aino Pippuri, Pentti Pohto, Tapio Korkolainen
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Patent number: 5876750Abstract: A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises a laminated wall for maintaining the integrity of the dosage form and of the antiepileptic drug.Type: GrantFiled: June 9, 1997Date of Patent: March 2, 1999Assignee: ALZA CorporationInventors: Frank Jao, Patrick S.-L. Wong, Evangeline Cruz, Eduardo C. Sy, Anthony L. Kuczynski
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Patent number: 5874476Abstract: Disclosed is a method of inhibiting the growth of microorganisms in, at, or on a locus subject to microbial attack, comprising introducing to said locus an antimicrobially effective amount of at least one dihaloformaldoxime carbamate.Type: GrantFiled: July 14, 1997Date of Patent: February 23, 1999Assignee: Rohm and Haas CompanyInventors: Adam Chi-Tung Hsu, Barry Clifford Lange, Jemin Charles Hsu
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Patent number: 5872143Abstract: A pre-mix insecticidal composition is disclosed that contains (a) 0.1-10% by weight of 2,4-dioxo-1-(2-propynyl)imidazolidin-3-ylmethyl chrysanthemate, (b) 2.5-50% by weight of a fatty acid ester of 16-19 carbon atoms; (c) 2.5-30% by weight of a sorbitan fatty acid ester; (d) 0.5-1% by weight of at least one alcohol selected from the group consisting of ethanol, 1-propanol, 2-propanol, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, butylene glycol and glycerin; and (e) 40-93.5% by weight of a saturated hydrocarbon of 8-18 carbon atoms. This pre-mix insecticidal composition exhibits little, if any, precipitation when left to stand. It is sufficiently stable to be transported and is storage stable prior to formulating an insecticidal aerosol composition. A useful insecticidal aerosol composition contains 5-30% by weight of this pre-mix insecticidal composition, 40-85% by weight of water and 10-50% by weight of a propellant. The aerosol composition is stable, i.e.Type: GrantFiled: August 6, 1997Date of Patent: February 16, 1999Assignee: Sumitomo Chemical Company, LimitedInventors: Yasuyori Tanaka, Tadahiro Matsunaga
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Patent number: 5863548Abstract: What is described is a light stable, whitish antimicrobial product which is a silver-allantoin complex encapsulated with allantoin. The molar ratio of silver-to-allantoin in the product is between 1:100 and 1:4.Type: GrantFiled: April 1, 1998Date of Patent: January 26, 1999Assignee: ISP Investments Inc.Inventor: Todd Elder
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Patent number: 5859040Abstract: Compositions comprising a compound of formula I ##STR1## where R and R' are independently selected from hydrogen and alkyl of 1 to 4 carbon atoms, R" is a moiety selected from the group consisting of (a) hydrogen, (b) a halogen atom selected from the group consisting of F, Cl, Br, and I, and (c) a nitro group, or the hydrochloride salt of said compound; and at least one preservative are disclosed which are synergistically effective compared to the respective components alone in controlling and/or reducing the growth of microorganisms in or on a material or medium. Methods to control and/or reduce the growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.Type: GrantFiled: May 27, 1997Date of Patent: January 12, 1999Assignee: Buckman Laboratories International, Inc.Inventors: Vanja M. King, Xiangdong Zhou
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Patent number: 5851406Abstract: A method to prevent the degradation of water soluble film placed in contact with halogenated hydantoin or chlorinated cyanuric acid and an apparatus for disinfecting water systems. Halogenated 5,5-dialkyl hydantoin or chlorinated cyanuric acid is combined with a stabilizing agent to prevent the halogenated hydantoin or chlorinated cyanuric acid from discoloring or degrading a polymeric film which it may contact. The oxidizing agent includes alkaline hydroxide, alkaline carbonates, alkaline bicarbonates, alkaline phosphates, alkaline silicates, and alkaline borates. Polymeric films for which this is suitable include 2-hydroxy propyl cellulose and poly(vinyl alcohol).Type: GrantFiled: November 22, 1995Date of Patent: December 22, 1998Assignee: Bio-Lab, Inc.Inventors: Ronald L. Jones, P. Kirk Mitchell
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Patent number: 5817685Abstract: Anticonvulsive compounds and compositions, of the formula ##STR1## in which X is a C.sub.1-4 -alkyl, trifluoromethyl, or halogen residue, Y is hydrogen or halogen, n is 0 or 1, and m is 0 or a cardinal number from 1 to 4, and its pharmacologically acceptable acid addition salts.Type: GrantFiled: August 21, 1996Date of Patent: October 6, 1998Assignee: Arzneimittelwerk Dresden GmbHInventors: Hans-Joachim Lankau, Manfred Menzer, Angelika Rostock, Klaus Unverferth
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Patent number: 5814233Abstract: A method of remediating methyl amine and/or methyl amine derivative odors in aqueous systems by contacting the methyl amine or methyl amine derivative with a compound having amide or imide functionality, such as a hydantoin composition, in the presence of hydrogen peroxide. The amide/imide composition is preferably a non-halogenated, singe-ring hydantoin that binds methyl amines to the amide or imide functional group of the hydantoin.Type: GrantFiled: November 10, 1997Date of Patent: September 29, 1998Assignee: Great Lakes Chemical CorporationInventors: Ron Starkey, Kysler DeGuzman, Geoffrey A. Brown, P. Kirk Mitchell
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Patent number: 5767140Abstract: A series of 5,5-disubstituted Hydantoin derivatives synthesized by alkylating 5,5-bis(thiomethyl)-2,4-imidazolidinedione with halomethyl aromatic or halomethyl heteroaromatic precursors or by using the Buchener-Berg procedure on the required ketone. This series of 5,5-disubstituted Hydantoin derivatives are biologically active in their ability to inhibit HIV-induced death and virus production in mammalian (human) cells.Type: GrantFiled: March 14, 1995Date of Patent: June 16, 1998Assignee: Southern Research InstituteInventors: Robert N. Comber, Robert C. Reynolds, Robert W. Buckheit, Jr.
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Patent number: 5756667Abstract: The present invention consists in a method of preparing amino thiohydantoins either in isolation or as the C-terminals residue of a peptide. The method comprises reacting the amino acid or peptide with an acylating agent and thiocyanate or isothiocyanates in the presence of a strong acid. The present invention also relates to an improved method for C-terminal sequencing of peptides which routinely analyses all of the common amino acids of peptides. The invention involves the use of a strong, volatile, anhydrous organic or mineral acid to cleave the terminal amino acid thiohydantoin.Type: GrantFiled: September 23, 1994Date of Patent: May 26, 1998Assignee: Garvan Institute of Medical ResearchInventors: Adam Inglis, Albert Peng Sheng Tseng, Peter Laurence Adams
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Patent number: 5747501Abstract: Compounds of the formula ##STR1## where W is ##STR2## n is 0, 1, or 2; m is 0, 1, 2, or 3: Y and G are each independently oxygen or sulfur; Z is --O--, --S--, --NH, or --CH.sub.2 ; R.sub.1 is hydrogen, C.sub.1 to C.sub.8 alkyl, substituted C.sub.1 to C.sub.8 alkyl substituted with one hydroxy, C.sub.3 to C.sub.8 alkenyl, C.sub.3 to C.sub.8 alkynyl, aryl, C.sub.1 to C.sub.3 alkylaryl, C.sub.1 to C.sub.3 alkylheteroaryl, or --Q--R.sub.4 ; R.sub.2 and R.sub.3 are each independently hydrogen, C.sub.1 to C.sub.6 alkyl, aryl, C.sub.1 to C.sub.3 alkylaryl, or C.sub.1 to C.sub.3 alkylheteroaryl; R.sub.4 is cyano, trifluoromethyl, --COR.sub.9, --CO.sub.2 R.sub.9, --CONR.sub.9 R.sub.10, --OR.sub.9, --SO.sub.2 NR.sub.9 R.sub.10, or --S(O).sub.q R.sub.9 ; R.sub.9 and R.sub.10 are each independently hydrogen, C.sub.1 to C.sub.8 alkyl, C.sub.1 to C.sub.3 alkylaryl, aryl, or R.sub.9 and R.sub.Type: GrantFiled: September 16, 1994Date of Patent: May 5, 1998Assignee: Pfizer, Inc.Inventors: John Eugene Macor, Martin James Wythes
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Patent number: 5712300Abstract: The present invention provides novel hydroxamic acid derivatives represented by the compound of formula I ##STR1## or pharmaceutical acceptable salts thereof, wherein the compounds of the present invention inhibit various enzymes from the matrix metalloproteinase family, including collagenase, stromelysin, and gelatinase, and hence are useful for the treatment of matrix metallo endoproteinase diseases such as osteoarthrits, rheumatoid arthritis, septic arthritis, osteopenias such as osteoporosis, tumor metastasis (invasion and growth), periodontitis, gingivitis, corneal ulceration, dermal ulceration, gastric ulceration, and other diseases related to connective tissue degradation.Type: GrantFiled: March 4, 1997Date of Patent: January 27, 1998Assignee: Pharmacia & Upjohn CompanyInventor: E. Jon Jacobsen
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Patent number: 5691335Abstract: The invention relates to an imidazolidine derivative represented by the following general formula (1): ##STR1## wherein A and B mean individually an aromatic hydrocarbon group which may be substituted by 1-3 substituents selected from halogen atoms, C.sub.1-4 alkyl groups, C.sub.1-4 alkoxy groups, C.sub.1-4 alkylenedioxy groups, a phenoxy group, a nitro group, a cyano group, a phenyl group, C.sub.2-5 alkanoylamino groups, a carboxyl group which may be esterified with a C.sub.1-4 alkyl or alkenyl group, carboxyalkyl groups which may be esterified with a C.sub.1-4 alkyl or alkenyl group, carboxyalkyloxy groups which may be esterified with a C.sub.Type: GrantFiled: March 28, 1996Date of Patent: November 25, 1997Assignee: Suntory LimitedInventors: Harukazu Fukami, Motoo Sumida, Shinjiro Niwata, Saki Kakutani, Saitoh Masayuki, Shibata Hiroshi, Kiso Yoshinobu
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Patent number: 5662940Abstract: Improved biocidal composition and method for controlling biofouling and microorganism population levels in recirculating water systems such as cooling towers, swimming pools or spas is disclosed and claimed. The composition comprises a hypochlorite donor and a bromide ion donor in proportions selected to maintain a mole ratio of the sum of all bromine containing species to the sum of all hypohalite species in the recirculating water of about 0.2 to about 20. The method comprises introducing into the recirculating water a mixture or combination of a hypochlorite donor and a bromide ion donor in an amount sufficient to maintain a ratio of the sum of all bromine containing species to the sum of all species in the recirculating water in the range of about 0.2 to about 20.Type: GrantFiled: June 7, 1995Date of Patent: September 2, 1997Assignee: University of HoustonInventors: Terry V. T. Hight, Jack V. Matson, Lawrence F. Rakestraw, Zhihe Zhang, Thomas C. Kuechler
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Patent number: 5658935Abstract: The invention concerns heterocyclic compounds of the general formula (I) in which A, B, R, R.sup.2, R.sup.3, W, Y, Z.sup.1, Z.sup.2 and r are as defined in the description, methods of preparing them and their use as inhibitors of thrombocyte aggregation, the metastization of carcinoma cells and the binding of osteoclasts on bone surfaces.Type: GrantFiled: January 17, 1996Date of Patent: August 19, 1997Assignee: Hoechst AktiengesellschaftInventors: Otmar Klingler, Gerhard Zoller, Bernd Jablonka, Melitta Just, Gerhard Breipohl, Jochen Knolle, Wolfgang Konig
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Patent number: 5648314Abstract: A slow-dissolving sanitizing and clarifying puck for use in water such as swimming pool water preferably includes about 63% to about 80% trichloro-s-triazinetrione, about 4% to about 12% sodium tetraborate, about 10% to about 22% aluminum sulfate, and about 1% to 5% glycoluril.Type: GrantFiled: May 15, 1995Date of Patent: July 15, 1997Assignee: Bio-Lab, Inc.Inventors: Thomas M. Lachocki, Oscar T. Ragin, Presley K. Mitchell
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Patent number: 5641783Abstract: Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R.sub.1 and R.sub.2 are hydrogen, a straight or branched chain alkyl, alkenyl or alkynyl of up to twenty carbon atoms in length or --(CH.sub.2).sub.w R.sub.5. If R.sub.1 or R.sub.2 is --(CH.sub.2).sub.w R.sub.5, w may be an integer from one to twenty and R.sub.5 may be an hydroxyl, halo, C.sub.1-8 alkoxyl group or a substituted or unsubstituted carbocycle or heterocycle. Alternatively, R.sub.1 and R.sub.2 may jointly form a substituted or unsubstituted, saturated or unsaturated heterocycle having from four to eight carbon atoms, N being a hetero atom of the resulting heterocycle. R.sub.3 may be either hydrogen or C.sub.1-3. In the compounds, a total sum of carbon atoms comprising R.sub.1 or R.sub.2, (CH.sub.2).sub.n and (CH.sub.2).sub.m does not exceed forty. R.sub.Type: GrantFiled: September 8, 1994Date of Patent: June 24, 1997Assignee: Cell Therapeutics, Inc.Inventors: J. Peter Klein, Gail E. Underiner, Anil M. Kumar
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Patent number: 5641520Abstract: A method for providing aqueous solutions of HOBr or HOCl which includes adding bleach (NaOCl) to a solution of HBr or HCl an identified absorbance or color change in the resulting solution is detected. Dialkylhydantoins are optionally added to the resulting solution to suppress the formation of halate ions. The method provides a simple and reliable method for producing accurately defined solutions of hypohalous acids, which are useful in a variety of ways, including for disinfecting, cleaning, and odor control purposes.Type: GrantFiled: June 7, 1995Date of Patent: June 24, 1997Assignee: Great Lakes Chemical CorporationInventors: Jonathan N. Howarth, Enrico J. Termine, Alan M. Yeoman
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Patent number: 5637606Abstract: The present invention provides a hair grower which prevents loss of hair, promoted hair development and cures alopecia, comprising as an active ingredient one or more of the following compounds: allantoin, derivatives thereof, compounds thereof and compounds of allantoin derivatives and optionally further comprising as an active ingredient one or more aluminum compounds.Type: GrantFiled: June 1, 1995Date of Patent: June 10, 1997Inventor: Toshihiro Matsumoto
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Patent number: 5631273Abstract: A water soluble preservative antimicrobial composition for addition to commercial use products at predetermined use levels to provide synergistic biocidal activity against a wide range of fungi and gram-negative and gram-positive bacteria, comprising an active liquid blend of(1) an admixture of(a) one or more methylol compounds selected from the group consisting of N-[1,3-bis (hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis (hydroxymethyl) urea; 1,3-dimethylol-5,5-dimethyl hydantoin; sodium hydroxymethyl glycinate; 1,1-methylene bis[3-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]urea]; and glycine anhydride dimethylol; and(b) 3-iodo-2-propynylbutyl carbamate, in a weight ratio of (a):(b) of 100:1 to 2000:1, and(2) propylene glycol or 1,3-butylene glycol.Type: GrantFiled: May 23, 1996Date of Patent: May 20, 1997Assignee: ISP Chemicals Inc.Inventor: John J. Merianos
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Patent number: 5614528Abstract: Compositions and methods are disclosed for sanitizing aqueous media, which combine a chlorine-source composition and a glycoluril-source composition. The compositions are added together or separately, continuously or periodically, and by any of a variety of methods. The glycoluril compound stabilizes the chlorine and prolongs its useful life as a microbicidal agent while additionally reducing the formation of chloramines, trihalomethanes and odors.Type: GrantFiled: October 17, 1994Date of Patent: March 25, 1997Assignee: Bio-Lab, Inc.Inventors: Ronald L. Jones, Henry D. Caughman, Susan M. Shelor, Ellwood L. Lines, Jr.
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Patent number: 5614541Abstract: New catechol derivatives and pharmaceutically acceptable salts and esters thereof useful as pharmaceutical antioxidants are disclosed. Cellular damage by oxygen derived radicals is a significant factor in heart disease, rheumatoid arthritis, cancer, inflammatory disease, transplant rejection reactions and ischemia.Type: GrantFiled: October 18, 1994Date of Patent: March 25, 1997Assignee: Orion-yhtym a OyInventors: Reijo B ackstr om, Erkki Honkanen, Inge-Britt Linden, Erkki Nissinen, Aino Pippuri, Pentti Pohto, Tapio Korkolainen
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Patent number: 5567725Abstract: Cyclohexanol esters of the formula I ##STR1## are described in which the radicals have the given meaning. The compounds are pharmacologically active and may therefore be used as pharmaceuticals, in particular for treating diabetes and other diseases which are characterized by an elevated secretion of glucose from the liver or by an elevated activity of the glucose-6-phosphatase system.Type: GrantFiled: February 14, 1995Date of Patent: October 22, 1996Assignee: Hoechst AktiengesellschaftInventors: Horst Hemmerle, Gerrit Schubert, Peter Below, Andreas Herling, Hans-J org Burger
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Patent number: 5527547Abstract: Improved biocidal composition and method for controlling biofouling and microorganism population levels in recirculating water systems such as cooling towers, swimming pools or spas is disclosed and claimed. The composition comprises a hypochlorite donor and a bromide ion donor in proportions selected to maintain a mole ratio of the sum of all bromine containing species to the sum of all hypohalite species in the recirculating water of about 0.2 to about 20. The method comprises introducing into the recirculating water a mixture or combination of a hypochlorite donor and a bromide ion donor in an amount sufficient to maintain a ratio of the sum of all bromine containing species to the sum of all species in the recirculating water in the range of about 0.2 to about 20.Type: GrantFiled: April 4, 1995Date of Patent: June 18, 1996Assignee: The University of HoustonInventors: Terry V. T. Hight, Jack V. Matson, Lawrence F. Rakestraw, Zhihe Zhang, Thomas C. Kuechler
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Patent number: 5496842Abstract: A water soluble preservative admixture of biocidal compounds for addition to commercial use compositions at predetermined use levels, and uniformly distributed therein, to provide long-time synergistic biocidal activity against a wide range of fungi and both gram-negative and gram-positive bacteria, which comprises powders of(a) one or more methylol compounds, or their equivalents, and(b) iodopropynyl alcohol, or its ester, carbamate or ether derivative thereof, in a weight ratio of (a):(b) of 100:1 to 2000:1.Type: GrantFiled: February 22, 1995Date of Patent: March 5, 1996Assignee: ISP Chemicals Inc.Inventor: John J. Merianos
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Patent number: 5494927Abstract: The novel 3,5-ditertiarybutyl-4-hydroxy-phenylmethylene derivative of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents having inhibiting activity for 5-lipoxygenase, cyclooxygenase, or both.Type: GrantFiled: December 9, 1994Date of Patent: February 27, 1996Assignee: Warner-Lambert CompanyInventors: Wiaczeslaw A. Cetenko, David T. Connor, Jagadish C. Sircar, Roderick J. Sorenson, Paul C. Unangst
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Patent number: 5476670Abstract: Improved biocidal composition and method for controlling biofouling and microorganism population levels in recirculating water systems such as cooling towers, swimming pools or spas is disclosed and claimed. The composition comprises a hypochlorite donor and a bromide ion donor in proportions selected to maintain a mole ratio of the sum of all bromine containing species to the sum of all hypohalite species in the recirculating water of about 0.2 to about 20. The method comprises introducing into the recirculating water a mixture or combination of a hypochlorite donor and a bromide ion donor in an amount sufficient to maintain a ratio of the sum of all bromine containing species to the sum of all species in the recirculating water in the range of about 0.2 to about 20.Type: GrantFiled: June 13, 1994Date of Patent: December 19, 1995Assignee: The University of HoustonInventors: Terry V. T. Hight, Jack V. Matson, Lawrence F. Rakestraw, Zhihe Zhang, Thomas C. Kuechler
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Patent number: 5476863Abstract: A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor.Type: GrantFiled: September 30, 1993Date of Patent: December 19, 1995Assignee: Eisai Co., Ltd.Inventors: Kazuo Okano, Osamu Asano, Naoyuki Shimomura, Tetsuya Kawahara, Shinya Abe, Shuhei Miyazawa, Mitsuaki Miyamoto, Hiroyuki Yoshimura, Koukichi Harada, Junsaku Nagaoka, Tsutomu Kawata, Tsutomu Yoshimura, Hiromasa Suzuki, Shigeru Souda, Yoshimasa Machida, Kouichi Katayama, Isao Yamatsu
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Patent number: 5466699Type: GrantFiled: December 5, 1994Date of Patent: November 14, 1995Assignee: Burroughs Wellcome Co.Inventors: Alan D. Robertson, Alan P. Hill, Robert C. Glen, Graeme R. Martin
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Patent number: 5464850Abstract: A family of solutions that can be used to calibrate one or more electrochemical sensors has been developed. These systems can be used to determine analytes in biological fluids, such as whole blood, serum, plasma and urine. Since these reagents require preservatives in order to make their shelf life and use life commercially feasible, a system of preservatives which exhibits unexpected synergy in antimicrobial capabilities has been identified. The preferred preservative system includes a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one; 2-methyl-4-isothiazolin-3-one; and 1,3-bis-(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione.Type: GrantFiled: May 17, 1994Date of Patent: November 7, 1995Assignee: Ciba Corning Diagnostics Corp.Inventors: Liann Voo, Dennis C. Tagliaferro, Joan B. Wilson
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Patent number: 5464636Abstract: Improved biocidal composition and method for controlling biofouling and microorganism population levels in recirculating water systems such as cooling towers, swimming pools or spas is disclosed and claimed. The composition comprises a hypochlorite donor and a bromide ion donor in proportions selected to maintain a mole ratio of the sum of all bromine containing species to the sum of all hypohalite species in the recirculating water of about 0.2 to about 20. The method comprises introducing into the recirculating water a mixture or combination of a hypochlorite donor and a bromide ion donor in an amount sufficient to maintain a ratio of the sum of all bromine containing species to the sum of all species in the recirculating water in the range of about 0.2 to about 20.Type: GrantFiled: March 14, 1994Date of Patent: November 7, 1995Assignee: The University of HoustonInventors: Terry V. T. Hight, Jack V. Matson, Lawrence F. Rakestraw, Zhihe Zhang, Thomas C. Kuechler
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Patent number: 5464856Abstract: The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula ##STR1## having activity useful for treating allergies and inflammation.Type: GrantFiled: January 24, 1994Date of Patent: November 7, 1995Assignee: Warner-Lambert CompanyInventors: Wiaczeslaw A. Cetenko, David T. Connor, Roderick J. Sorenson, Paul C. Unangst, Stephen R. Stabler
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Patent number: 5459133Abstract: This invention is directed to treatment for increasing the accommodative ability of the eye, for the purpose of decreasing the severity of clinically evident presbyopia, an age-related loss of accommodative ability. The compounds and methods of the invention act by decreasing the tone of parts of the ciliary muscle which act to decrease accommodation, thereby increasing the contractile force of the remaining ciliary muscle, with resultant increased accommodative function.Type: GrantFiled: June 5, 1992Date of Patent: October 17, 1995Assignee: Telor Ophthalmic Pharmaceuticals, Inc.Inventor: Arthur H. Neufeld
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Patent number: 5447946Abstract: Hydantoin derivatives and salts thereof, intermediates therefor, process for the preparation thereof, and medicines containing the derivative, wherein said derivatives have the formula ##STR1## wherein one of V and W is hydrogen and the other is a halogenomethyl group, 1H-tetrazol-5-yl radical, --COOR group,in which R is hydrogen atom, an alkyl group, --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n is an integer of 1 to 113) or substituted phenyl, ##STR2## in which R.sub.1 and R.sub.2 are same or different independently, each is hydrogen atom, an alkyl group, substituted phenyl or --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n has the meaning as referred to) or R.sub.1 may form a heterocyclic ring together with R.sub.2 and nitogen or oxygen atom,--CH.sub.2 OH.sub.3 group or ##STR3## group, in which R.sub.3 and R.sub.Type: GrantFiled: September 23, 1994Date of Patent: September 5, 1995Assignee: Sanwa Kagaku Kenkyusho Co., Ltd.Inventors: Masayasu Kurono, Yasuaki Kondo, Takuji Yamaguchi, Kenji Miura, Toshinao Usui, Naofumi Terada, Kyoichi Asano, Kuniharu Mizuno, Akira Matsubara, Noriaki Kato, Kiichi Sawai, Ryoichi Unno, Hiroshi Ozawa, Masato Fukushima