Bicyclo Ring System Having The Hetero Ring As One Of The Cyclos (e.g., Chromones, Etc.) Patents (Class 514/456)
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Publication number: 20130309218Abstract: The purpose of the present invention is to provide a process for producing an aqueous solution containing a fat-soluble substance. A combination of a super dissolution aid, cyclodextrin and a fat-soluble substance or a combination of the super dissolution aid and a cyclodextrin complex of the fat-soluble substance is used for dissolving the fat-soluble substance, whereby it becomes possible to provide an aqueous solution containing the fat-soluble substance at a high concentration and an aqueous solution having improved transdermal absorbability of the fat-soluble substance contained therein.Type: ApplicationFiled: January 31, 2012Publication date: November 21, 2013Applicant: WACKER CHEMIE AGInventors: Keiji Terao, Hiroshi Fukumi, Daisuke Nakata, Yukiko Uekaji, Ayako Jo
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Publication number: 20130309249Abstract: Described herein are materials and methods for the prophylactic treatment of a pre-malignant condition, comprising administering a SIRT1 agonist to an individual whose genotype comprises one defective BRCA1 allele and one functional BRCA1 allele.Type: ApplicationFiled: April 24, 2013Publication date: November 21, 2013Inventors: Charlotte Kuperwasser, Maja Sedic
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Publication number: 20130310448Abstract: This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition have the capacity to Inhibit functions of ATR and FANCD2 on DNA replication, damage checkpoint, and repair; therefore, this composition can improve the cancer sensitivity and poor prognosis to DNA-damaging therapeutics.Type: ApplicationFiled: December 13, 2012Publication date: November 21, 2013Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Hui-Chun WANG, Yang-Chang WU, Fang-Rong CHANG, Chin-Chung WU
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Publication number: 20130310329Abstract: There is disclosed a combination of inhibitors of Tissue Transglutaminase (TG2), inhibitors of reactive oxygen species (ROS) and CFTR channel activators (potentiators) for separate, sequential or simultaneous administration to CF patients carrying the ?F508-CFTR mutation, and pharmaceutical compositions thereof.Type: ApplicationFiled: May 16, 2013Publication date: November 21, 2013Applicant: I.E.R.F.C. EUROPEAN INSTITUTE FOR CYSTIC FIBROSIS RESEARCHInventor: I.E.R.F.C. European Institute For Cystic Fibrosis Research
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Publication number: 20130310449Abstract: The present invention provides compositions having synergistic antioxidant properties in the modulation of Toll-like receptor signaling for the promotion of homeostasis, immunity, energy conservation, protection of neural cells and anti-inflammatory responses, said compositions comprising plant and/or fruit extracts and a natural sweetener with high oxidation potential as defined by ORAC value.Type: ApplicationFiled: February 1, 2012Publication date: November 21, 2013Inventor: Sophie Chabot
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Publication number: 20130310254Abstract: The present application relates to novel alpha, beta-unsaturated imines, to processes for their preparation, to their use for controlling animal pests including arthropods and in particular insects and to their use in the control of vectors.Type: ApplicationFiled: November 24, 2011Publication date: November 21, 2013Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Stefan Werner, Ulrich Ebbinghaus-Kintscher, Sebastian Horstmann, Michael Maue, Hans-Georg Schwarz, Robert Velten, Arnd Voerste, Ulrich Görgens, Andreas Turberg
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Publication number: 20130309202Abstract: The present invention provides methods to improve liver function utilizing tocotrienols. In particular, various liver pathologies may be treated using the present methods, including cirrhosis, hepatitis, and sclerosing cholangtitis. The present invention also provides methods to increase tissue concentrations of tocotrienols.Type: ApplicationFiled: May 20, 2013Publication date: November 21, 2013Applicant: The Ohio State UniversityInventors: Chandan K. Sen, Cameron L. Rink, Sashwati Roy, Savita Khanna
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Patent number: 8586768Abstract: A method of synthesizing rottlerin analogs is described. The synthesis methods described are the first known method of synthesizing rottlerin analogs from commercially-available materials to produce cost effective analogs. Rottlerin analog structures made by the synthesis methods and methods of use for treating a neurological or inflammatory response mediated by protein kinase C (PKC) are further described.Type: GrantFiled: November 12, 2010Date of Patent: November 19, 2013Assignee: Iowa State University Research Foundation, Inc.Inventors: Anumantha G. Kanthasamy, George A. Kraus, Vellareddy Anantharam
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Publication number: 20130303474Abstract: The present invention relates to a composition for enhancing immunity through inducing the expression of interferon-? comprising a compound represented by Formulas 1 to 8, or Sophora flavescens extract comprising the same and fractions thereof as an active ingredient, a feed additive, feed composition, pharmaceutical composition, food composition, and over-the-counter (OTC) drug composition comprising the composition, and a method for enhancing immunity through administrating the composition. A composition for inducing the expression of interferon-?, comprising a compound represented by Formulas 1 to of the present invention, Sophora flavescens extract comprising the same, or fractions thereof as active ingredient can prevent, alleviate, or treat the diseases that can be prevented or treated by increasing the expression of interferon.Type: ApplicationFiled: March 28, 2011Publication date: November 14, 2013Applicant: Korea Research Institute of Bioscience and BiotechInventors: Mun Chual Rho, Woo Song Lee, Kyoung Oh Cho, Su Jin Park, Young Bae Ryu, Young Min Kim, Seung Woong Lee, Ji Hak Jeong, Mi Hye Park, Jong Sun Chang
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Publication number: 20130303544Abstract: The present invention provides a kind of benzopyrone compounds having a structure of formula (I) and the pharmaceutically acceptable salts or prodrugs thereof, and the pharmaceutical compositions containing such compounds, which can be used to regulate the novel estrogen receptor ER-a36, and prevent and/or treat the related diseases mediated by the ER-a36 receptor, such as cancers, etc.Type: ApplicationFiled: December 21, 2011Publication date: November 14, 2013Applicant: BEIJING SHENOGEN PHARMA GROUP LTD.Inventors: Hongxia Ding, Kun Meng, Jin Li
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Publication number: 20130303604Abstract: Tea polyphenols are used to prevent or treat tumors such as leukemia and myeloma, malignant tumors in a hematopoietic system. The tea polyphenols are tea extracts comprising EGCG, EGC, and ECG, or Tegreen97®, a green tea capsule of PHARMANEX, INC.Type: ApplicationFiled: July 15, 2013Publication date: November 14, 2013Inventors: Li Zhang, Yunhua Liu
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Patent number: 8581005Abstract: The present invention relates to inhibitors of mitochondria-associated, granulocyte-macrophage colony stimulating factor signaling molecule (Magmas), and related compositions and uses thereof.Type: GrantFiled: March 16, 2010Date of Patent: November 12, 2013Assignee: Albert Einstein College of Medicine of Yeshiva UniversityInventors: Paul Jubinsky, Bhaskar C. Das, Mary K. Short
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Publication number: 20130296419Abstract: Foods and pharmaceuticals which contain cocoa and/or nut procyanidin(s) in combination with L-arginine are effective to induce a physiological increase in nitric oxide production in a mammal having ingested the product. A preferred food product is a confection, particularly a dark or milk chocolate containing nuts. The procyanidins may be natural or synthetic and may be provided by food ingredients such as chocolate liquor and/or cocoa solids prepared from underfermented beans and nut skins. The L-arginine may be natural or synthetic and may be provided by food ingredients such as nut meats, nut pastes, and/or nut flours, seeds, seed pastes, and/or seed flours, or gelatin. The beneficial health effects may include, for example, reduced blood pressure, resistance to cardiovascular disease, and anticancer activity.Type: ApplicationFiled: July 8, 2013Publication date: November 7, 2013Inventors: Kati A. CHEVAUX, Harold H. SCHMITZ, Leo J. ROMANCZYK
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Publication number: 20130296417Abstract: A process for producing a purified extract comprising between about 40% and about 90% theaflavins is provided. Purified theaflavin extract produced by the disclosed process is provided which comprises less than about 5% TF1, between about 10% and about 60% TF2a, between about 5% and about 35% TF2b, and between about 10% and about 65% TF3. Individual dosage compositions are provided for the control of a physiological disorder comprising about 5% to about 95% theaflavins in a pharmaceutically acceptable vehicle or a dietary supplement vehicle. Further individual dosage compositions are provided which comprise an effective amount of substantially only one theaflavin species selected from the group consisting of TF1, TF2a, TF2b, and TF3. Individual dosage compositions are provided which comprise an effective amount of substantially only two theaflavin species selected from the group consisting of TF1 and TF2a, TF1 and TF2b, TF1 and TF3, TF2a and TF2b, TF2a and TF3, TF2b and TF3.Type: ApplicationFiled: June 28, 2013Publication date: November 7, 2013Applicant: JANGSU DEHE BIO-TECH CO., LTD.Inventors: Xiaowei Shi, Xueyn Ren, Jiannong Liu, Wenhao Ren, Yiznou Cao
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Publication number: 20130296418Abstract: The invention relates to a cosmetic composition containing lingonberry extract and its use on skin cosmetology thereof. The present invention has provided a lingonberry extract wherein containing polyphenols components including anthocyanidin, procyanidin, resveratrol, catechin and so on. The present invention also relates to the application of lingonberry extract on skin cosmetology, including without limitation whitening, diminishing visible pigmentation, anti-wrinkle, moisturizing, smoothing and improving skin sensitivity. The invention also has revealed drugs, cosmetic compositions and food prepared by using lingonberry extract. Comparing with the prior art cosmetic compositions, the said lingonberry extract of the present invention has higher effects and safe.Type: ApplicationFiled: July 3, 2013Publication date: November 7, 2013Applicant: Beijing Gingko Group Biological Technology Co., Ltd.Inventors: Chunhua Li, Yanmei Li
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Publication number: 20130296416Abstract: Provided are methods of treating heart failure in children using B1-selective adrenergic receptor antagonists, alone or in combination with other agents, including B-2-selective adrenergic receptor agonists.Type: ApplicationFiled: August 25, 2011Publication date: November 7, 2013Applicant: The Regents of the University of Colorado, A Body CorporateInventors: Brian Stauffer, Carmen Sucharov, Shelley Miyamoto
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Publication number: 20130295199Abstract: This invention relates to a composition comprising oligoproanthocyanidins (OPC) and omega-3 fatty acids, for use in preventing or stabilizing the development and/or the progression of a diabetes-related eye condition in a subject; this invention includes a functional food, a nutraceutical composition or a food or dietary supplement comprising said composition; this invention also relates to a pharmaceutical composition or a veterinarian product comprising oligoproanthocyanidins (OPC) and omega-3 fatty acids.Type: ApplicationFiled: January 13, 2012Publication date: November 7, 2013Applicant: VISIOTACT PHARMAInventors: Reda Hadj-Slimane, Yves Lepelletier, Tewfik Hadj-Slimane
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Patent number: 8575368Abstract: This invention provides useful applications of cashew apple. This invention also provides a naturally occurring active ingredient having useful activities, such as alpha-amylase inhibitory activity, lipase inhibitory activity, and antibacterial activity against Propionibacterium acnes. The invention also provides a composition containing cashew apple-derived proanthocyanidin having excellent alpha-amylase inhibitory activity, lipase inhibitory activity, and antibacterial activity against Propionibacterium acnes, which is prepared by allowing a plant fiber-degrading enzyme (e.g., pectinase) to react with a cashew apple and concentrating the resultant with the use of an ultrafiltration membrane. Further, the invention provides a proanthocyanidin compound having a novel structure.Type: GrantFiled: June 25, 2009Date of Patent: November 5, 2013Assignee: Nichirei Biosciences, Inc.Inventor: Kenichi Nagamine
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Publication number: 20130289034Abstract: Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, and stroke (MELAS), Kearns-Sayre Syndrome (KSS), are disclosed, as well as compounds useful in the methods of the invention, such as 4-(p-quinolyl)-2-hydroxybutanamide derivatives. Methods and compounds useful in treating other disorders such as amyotrophic lateral sclerosis (ALS), Huntington's disease, Parkinson's disease, and pervasive developmental disorders such as autism are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.Type: ApplicationFiled: June 21, 2013Publication date: October 31, 2013Inventors: Orion D. JANKOWSKI, Kieron E. WESSON, Paul MOLLARD, William D. SHRADER
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Publication number: 20130287918Abstract: The present invention provides a composition comprising (a) allyl isothiocyanate; and (b) an organic acid selected from acetic acid, propionic acid and mixtures thereof and optionally further comprising (c) green tea [Camellia sinensis] extract.Type: ApplicationFiled: December 22, 2011Publication date: October 31, 2013Applicant: DUPONT NUTRITION DIOSCIENCES APSInventors: Jana Theresa Fischer, Brett Wesley Thompson
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Publication number: 20130289103Abstract: This invention pertains to an anti-microbial, in particular anti-bacterial and/or anti-fungal composition comprising cinnamaldehyde, trans-2-methoxy cinnamaldehyde, cinnamyl acetate and linalool. In particular this composition is intended for preventing and/or treating microbial infection in an animal.Type: ApplicationFiled: December 9, 2011Publication date: October 31, 2013Applicant: SEPTEOSInventor: Nicolas Tesse
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Publication number: 20130289067Abstract: Inhibitors of HIV-1 protease and compositions containing them are described. Use of the inhibitors and compositions containing them to treat HIV, AIDS, and AIDS-related diseases is described.Type: ApplicationFiled: June 27, 2013Publication date: October 31, 2013Inventors: Arun K. GHOSH, Bruno D. Chapsal, Hiroaki Mitsuya
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Publication number: 20130288989Abstract: Use of chemical ingredients in Cynomorium as phytoestrogen is provided by the present invention. Particularly, use of Cynomorium, extracts of Cynomorium, or at least one ingredient chosen from chrysophanol, emodin, catechin, (?)-epicatechin-3-O-gallate, naringenin-4?-O-glucopyranoside, and phlorizin, in manufacturing medicaments for treating and/or preventing diseases related to insufficient of estrogen secretion in mammal (for example, human), or use in manufacturing medicaments used as phytoestrogens is provided by the present invention. The extracts of Cynomorium, compositions containing extracts of Cynomorium or active ingredients thereof, and methods of treating and/or preventing diseases related to insufficient of estrogen secretion are also provided by the present invention.Type: ApplicationFiled: October 14, 2010Publication date: October 31, 2013Applicant: TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINEInventor: Xiumei Gao
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Patent number: 8569522Abstract: Compounds of Formula (I): in which A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.Type: GrantFiled: June 24, 2009Date of Patent: October 29, 2013Assignee: Array BioPharma Inc.Inventors: Laurence E. Burgess, Christopher T. Clark, Adam Cook, Christopher P. Corrette, Robert Kirk DeLisle, George A. Doherty, Kevin W. Hunt, Todd T. Romoff
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Patent number: 8568805Abstract: This invention relates to compositions containing polyphenols, for example, cocoa polyphenols such as flavanols and their related oligomers, and methods for treating abnormalities in gap junctional communication of cells, such as cancer, heart arrhythmia, neuro-degenerative diseases and cognitive dysfunction.Type: GrantFiled: March 2, 2009Date of Patent: October 29, 2013Assignee: Mars, Inc.Inventor: Helmut Sies
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Publication number: 20130281524Abstract: The present invention relates to the treatment or prevention of disorders where modulation of connexin 26 and/or p38 expression may be beneficial, and to tonabersat or an analogue of formula (I), and compositions comprising tonabersat or an analogue of formula (I) for use in said treatments.Type: ApplicationFiled: June 4, 2009Publication date: October 24, 2013Inventors: Peter Blower, Paul Sharpe, Paul Durham
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Publication number: 20130281526Abstract: A method for treating irritable bowel syndrome with diarrhea in a mammalian subject, which comprises administering to the subject in need thereof an effective amount of a fatty acid derivative is provided.Type: ApplicationFiled: April 22, 2013Publication date: October 24, 2013Applicant: SUCAMPO AGInventor: Ryuji UENO
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Publication number: 20130281525Abstract: Provided herein are novel agents that modulate AhR activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis. The agents comprise AhR inhibitors or non-constitutive AhR agonists of Formula (I) and (II) for the inhibition of cancer cell growth and parameters that characterize tumor metastasis, such as tumor cell invasiveness.Type: ApplicationFiled: July 27, 2011Publication date: October 24, 2013Applicants: TRUSTEES OF BOSTON UNIVERSITY, BOSTON MEDICAL CENTER CORPORATION, NORTHEASTERN UNIVERSITYInventors: David H. Sherr, Michael Pollastri, Jennifer Schlezinger, Sarah Haigh Molina, Scott Schaus, Joshua Robert Giguere
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Publication number: 20130281527Abstract: The invention relates to a process for extracting one or more polyphenols from fruits such as apples and to uses of said extracts in the treatment or prophylaxis of cardiovascular disease, colon cancer and digestive health.Type: ApplicationFiled: June 21, 2013Publication date: October 24, 2013Inventors: Richard Wood, Paul Kroon, Ricky Lee Green
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Patent number: 8563601Abstract: The present disclosure is in relation to the use of a composition comprising pentameric type A procyanidin, trimeric procyanidin and tetrameric procyanidin, optionally along with pharmaceutical excipient(s), in management of broncho-constrictive conditions such as Allergic Rhinitis, Asthma, and Chronic obstructive pulmonary disease (COPD).Type: GrantFiled: July 27, 2011Date of Patent: October 22, 2013Assignee: Indus Biotech Private LimitedInventors: Sunil Bhaskaran, Mohan Vishwaraman
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Publication number: 20130274320Abstract: The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.Type: ApplicationFiled: June 7, 2013Publication date: October 17, 2013Inventors: Xicheng Sun, Jian Qiu, Jan Wasley
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Publication number: 20130273177Abstract: Provided herein is a pharmaceutical composition comprising an isoflavonoid derivative and a cyclodextrin. Also provided herein are methods of treating cancer, sensitizing cancer cells, and inducing apoptosis in cancer cells by administering such compositions. In specific instances, provided herein are intravenous compositions and therapies.Type: ApplicationFiled: November 1, 2011Publication date: October 17, 2013Applicant: MARSHALL EDWARDS, INC.Inventor: Ofir Moreno
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Publication number: 20130274212Abstract: The present invention relates to sesterterpene compounds, to the precursors thereof that are hydrolysable in a living body, or to the pharmaceutically acceptable salts thereof, and also relates to the prevention and treatment efficacy of the sesterterpene compounds with respect to non-insulin dependent diabetes mellitus, diabetic complications (renal failure and foot ulcers caused by diabetes), alcoholic, non-alcoholic, and viral fatty liver diseases, obesity, hyperlipidemia, atherosclerosis, cardiovascular diseases such as atherosclerotic stroke, and cerebropathies (Parkinsonism, schizophrenia and Alzheimer's disease). In addition, the present invention relates to compositions for functional foods, functional beverages, functional cosmetics, and functional feed.Type: ApplicationFiled: September 7, 2011Publication date: October 17, 2013Applicant: SNU R&DB FOUNDATIONInventors: Heon Joong Kang, Dong Hwan Won, In Ho Yang, Eun Oh Kim, Jung Ah Kim, Awadut Gajendra Giri, Venkat Reddy Mallepally
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Publication number: 20130267477Abstract: The method of using nutritional compounds including Dihydroquercetin (taxifolin), Arabinogalactan and Arabinogalactan combined with Dihydroquercetin (taxifolin) to reduce and control cardiometabolic risk factors, associated with metabolic syndrome and hypercholesterolemia in a mammal, specifically a human, resulting in the enhancement of metabolism, reduced control levels of cholesterol and triglycerides, reduced oxidative damage in humans and other health benefits.Type: ApplicationFiled: April 10, 2012Publication date: October 10, 2013Applicant: FLAVITPURE, INC.Inventors: Sergey V. Philippov, Igor M. Bogorodov
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Publication number: 20130267538Abstract: The invention relates the method of treatment or amelioration of mitochondrial disorders such as Alzheimer's disease, Parkinson's disease, Friedreich's ataxia (FRDA), cerebellar ataxias, Leber's hereditary optic neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Myoclonic Epilepsy with Ragged Red Fibers (MERFF), amyotrophic lateral sclerosis (ALS), motor neuron diseases, Huntington's disease, macular degeneration, and epilepsy, with chroman derivatives of Formula I or Formula II as described herein.Type: ApplicationFiled: April 24, 2013Publication date: October 10, 2013Inventors: Gail WALKINSHAW, Sekhar BODDUPALLI, Bing WANG, Guy M. MILLER
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Publication number: 20130267586Abstract: The present invention provides compounds of the formula Formula I or a salt thereof: and the uses of such compounds for the treatment of a disease or disorder involving oxidative damage, for preventing UV damage to the skin of a mammal and for preventing or reversing the effects of ageing, or for treating or preventing dry skin.Type: ApplicationFiled: October 13, 2011Publication date: October 10, 2013Applicant: ANTOXIS LIMITEDInventors: Donald Barton McPhail, Graeme James Cook, Richard Charles Hartley
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Patent number: 8551530Abstract: The present invention is directed to formulations of genistein and methods for making and using the same. In particular embodiments, the formulations described herein include suspension formulations of nanoparticulate genistein.Type: GrantFiled: March 2, 2012Date of Patent: October 8, 2013Assignee: Humanetics CorporationInventors: Edmund Joseph Elder, Jr., Mark Joseph Sacchetti, Randall Joseph Tiachac, John L. Zenk
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Publication number: 20130261142Abstract: The present invention discloses compounds for the treatment of cancer and its application. These compounds comprises one of the following compound: Ammonium pyrrolidinedithiocarbamate Bay 11-7085 BIO Brefeldin A (+)-Butaclamol Calcimycin Calmidazoliur chloride Chelerythrine chloride CK2 Inhibitor 2 CGP-74514A hydrochloride CGS-12066A meleate Dequalinium dichloride Dihydroouabain Diphenyleneiodonium chloride Emetine dihydrochloride hydrate GR 127935 hydrochloride Nifedipine 6-Nitroso-1,2-benzopyrone Palmitoyl-DL-Carnitine chloride Parthenolide PD 169316 1,10-Phenanthroline monohydrate 4-Phenyl-3-furoxancarbonitrile Prazosin hydrochloride Protoporphyrin IX disodium Quinacrine dihydrochloride Quabain Retinoic acid p-hydroxyanilide Rottlerin Sanguinarine chloride Tetraethylthium disulfide and SU 9516.Type: ApplicationFiled: December 15, 2010Publication date: October 3, 2013Inventor: Hung-Cheng Lai
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Publication number: 20130259999Abstract: The combination of EGCG and a derivative of a basic amino acid has been found to be an effective anti-yeast agent in acidic food. The present invention relates to a method for controlling or preventing the growth of yeast in acidic food (i.e. with a pH between 2 and 6) including adding to the food a) epigallocatechin gallate (EGCG) and b) a derivative of a basic amino acid, and/or a salt thereof, as an anti-yeast agent. The present invention further relates to a composition for addition to food and to an acidic food including the composition, which includes a) epigallocatechin gallate and b) both lauric arginate and polylysine.Type: ApplicationFiled: December 14, 2011Publication date: October 3, 2013Applicant: PURAC BIOCHEM B.V.Inventors: Eelco Anthonius Johannes Heintz, Saurabh Kumar
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Publication number: 20130261045Abstract: The subject invention concerns materials and methods for treating or preventing a neurodegenerative condition or disease associated with ?-amyloid peptide deposition in neural tissue in a person or animal by administering a therapeutically effective amount of a polyphenol, or an analog, isomer, metabolite, or prodrug thereof, that increases expression or activity of a protein that exhibits ?-secretase activity. The subject invention also provides methods to increase ?-secretase expression and/or activity in cells by administering polyphenol flavonoids like (?)-epigallocatechin-3-gallate (EGCG) and epicatechin (EC), two polyphenols derived from green tea and other plants and that can be produced synthetically. Furthermore, there are provided methods to decrease or inhibit the production of A?1-40 or A?1-42 by administering the EGCG and EC compounds, their analogs, metabolites, and prodrugs.Type: ApplicationFiled: December 7, 2012Publication date: October 3, 2013Inventors: ROLAND DOUGLAS SHYTLE, JUN TAN
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Publication number: 20130259931Abstract: The present invention is directed to pharmaceutical compositions comprising nebivolol. More particularly, the present invention is directed to oral pharmaceutical compositions comprising nebivolol hydrochloride having a specific surface area of less than 22×103 cm2/g, and process for preparing the same.Type: ApplicationFiled: March 30, 2012Publication date: October 3, 2013Inventors: Bandi Parthasaradhi Reddy, Podili Khadgapathi, Goli Kamalakar Reddy
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Patent number: 8546445Abstract: A composition which is adapted for oral consumption comprising daidzein and an anthocyanidin, wherein the weight ratio of daidzein to anthocyanidin is in the range of from 1:1 to 1:100, wherein the daidzein is in the form of a pre-prepared aqueous dispersion, and wherein the composition is free of soy protein, which can exhibit an anti-inflammatory effect in skin, the use of a composition containing daidzein and an anthocyanidin for obtaining an anti-inflammatory effect in the skin and a method of reducing skin inflammation through the oral consumption of the composition.Type: GrantFiled: December 3, 2009Date of Patent: October 1, 2013Assignee: Conopco, Inc.Inventors: John Casey, Gail Jenkins, Linda Jane Wainwright
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Patent number: 8546376Abstract: The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer.Type: GrantFiled: September 17, 2010Date of Patent: October 1, 2013Assignee: Almac Discovery LimitedInventors: Mark Peter Bell, Timothy Harrison, Sumita Bhattacharyya, James Samuel Shane Rountree, Frank Burkamp, Stephen Price, Calum MacLeod, Richard Leonard Elliott, Phillip Smith, Toby Jonathan Blench, Colin Roderick O'Dowd, Lixin Zhang, Graham Peter Trevitt, Hazel Joan Dyke
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Publication number: 20130251776Abstract: A method for forming an antimicrobial composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and protein within a melt blending device (e.g., extruder) is provided. Despite the problems normally associated with melt processing proteins, the present inventors have discovered that the processing conditions and components may be selectively controlled to allow for the formation of a stable, melt-processed composition that is able to exhibit good mechanical properties. For example, the extrusion temperature(s) and shear rate employed during melt blending are relatively low to help limit polypeptide dissociation, thereby minimizing the impact of aggregation and embrittlement.Type: ApplicationFiled: May 22, 2013Publication date: September 26, 2013Applicant: Kimberly-Clark Worldwide, Inc.Inventors: Vasily A. Topolkaraev, Neil T. Scholl, Jaehong Lee, Dianna L. Ambrose, YoungSook Kim
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Publication number: 20130253047Abstract: A method and composition for preventing and treating avian influenza utilizes an effective quantity of polyphenolic(s) and its derivatives in combination with a carrier. The anti-avian influenza ingredient having a composition selected from the group consisting of theaflavin, theaflavin-3,3?-digallate, theaflavin-3-monogallate, theaflavin-3 gallate, theaflavin-3?-gallate, thearubigin, gallic acid, tannic acid, (?)-epigallocatechin gallate (EGCG), (?)epigallocatechin (EGC), (+)-epicatechin (EC), (?)-gallocatechin gallate (GCG), and catechin.Type: ApplicationFiled: May 22, 2013Publication date: September 26, 2013Applicant: Abattis Bioceuticals CorpInventors: Charles Hensley, Sung Pyo
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Publication number: 20130251730Abstract: Suggested is a compound of the formula (X) or any salt of a compound of the formula (X) or any mixture containing or consisting of two or more different compounds of the formula (X), two or more different salts of compounds of the formula (X) or one or more different compounds of the formula (X) and one or more different salts of compounds of the formula (X), wherein for R1, R2 and R3 independently of one another in every compound of the formula (X) the following applies: R1 means hydrogen or methyl, R2 means an organic residue with 5 carbon atoms and one oxygen atom or none and R3 means an organic residue with 10 carbon atoms and one or more oxygen atoms, or R1 and R2 together with the carbon atoms in positions 4 and 5 and the oxygen atom bound to the carbon atom in position 4 form a ring and comprise 5 carbon atoms and one oxygen atom or none, and R3 means an organic residue with 10 carbon atoms and one or more oxygen atoms, for use in a method for the prophylaxis and/or treatment of inflammation.Type: ApplicationFiled: March 1, 2013Publication date: September 26, 2013Applicant: Symrise AGInventors: Jakob Ley, Katharina Reichelt, Marcus Götz, Maria Blings, Veronika Somoza, Jessica Walker, Joel Michael Walker
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Publication number: 20130252911Abstract: A composition having anti-lice properties comprising effective amounts of at least one monoalkyl and/or dialkyl quat and/or amidoquat in combination with flavonoid-containing extracts obtained from Citrus plants and/or one or more isolated Citrus flavonoids. Advantages are: said preparation has strong physical insecticidal effects and facilitates the removal of lice eggs and nits from the hair.Type: ApplicationFiled: November 2, 2009Publication date: September 26, 2013Applicant: ALPHA-BIOCARE GMBHInventors: Heinz Mehlhorn, Guenter Schmahl, Juergen Schmidt, Fathy Abdel Ghaffar
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Publication number: 20130252925Abstract: The present invention relates to TRPV1 selective agonist topical compositions including capsaicinoid and analgesic agent compositions and methods of manufacture and methods of providing pain relief as well as treating a variety of disorders with such compositions.Type: ApplicationFiled: March 12, 2013Publication date: September 26, 2013Applicant: API Genesis, LLCInventors: Daniel Bucks, Philip J. Birbara
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Publication number: 20130251732Abstract: Methods for inhibiting the motility or proliferation of premalignant and malignant cells are provided. Methods for treating a malignancy of the head and neck and for treating a malignancy of the lung are also provided.Type: ApplicationFiled: November 30, 2011Publication date: September 26, 2013Applicant: Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center ("Fox ChaseInventors: Margie L. Clapper, Ekaterina G. Shatalova, Sibele Meireles
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Publication number: 20130245112Abstract: The invention relates to the use of at least davanone and 1,8-cineol for the manufacture of an antimicrobial and/or antiinflammatory composition as well as a method of producing said composition.Type: ApplicationFiled: March 13, 2013Publication date: September 19, 2013Applicant: Denovastella ABInventors: Jan Faergemann, Thomas Hedner, Olov Sterner, Lars Bjork