Tocopherols (e.g., Vitamin E, Etc.) Patents (Class 514/458)
  • Patent number: 10377792
    Abstract: This invention is in the field of micro-organism and algal cell processing. The invention relates to a method of maximizing migration of micro-organism and/or algal cells to a solvent fraction while simultaneously displacing water in a separate fraction and subsequent extraction of hydrophobic products from the organisms. The invention further relates to a method of sequestration of protein from an aqueous phase to an organic solvent.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: August 13, 2019
    Assignee: The Texas A&M University System
    Inventors: Sandun D. Fernando, Varun M. Gejji
  • Patent number: 10376610
    Abstract: In present invention oxidation method of viscon cellulose with NO2 obtained H3PO4/HNO3 is defined liquid and gas media. Regenerated oxidise cellulose (REOC in shorten term) contain in —COOH yields are standardised as 18.6-20.1 for textile, 19.8-21.5% for powder samples. Powder and textile (woven and fabric) products are impregnated 1.8-2.4% Ca+2 ion, 0-1.1% Na+1 ion, 0.8-1.5% tranexamic acid and 6-aminocaproic acid as antifibrinolytic. Obtained powder and gel products are impregnated Bi+3, Zn+2 and Ag+1 ions for antiseptic purposes. Only Bismuth of them is shown antibacterial effects. Also the aim of present invention is haemostat antimicrobial properties during impregnation of Rifampicin, Gatifloxacin, Doxycycline, Levofloxacin, Lincomycin, Clindamycin, Ciprofloxacin. Haemostatic properties are indicated for all products and antimicrobial properties are shown for some samples. Cytotoxicity, sensitivity and irritation properties are determined in compliance of Pharmacopeias.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: August 13, 2019
    Inventor: Mevlut Ertan
  • Patent number: 10362800
    Abstract: The present invention relates to improved vitamin E formulations, as well as to the production of such formulations.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: July 30, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Martin Gadient, Thomas Lindemann, Mischa Schwaninger, Karl Manfred Voelker, Kai Urban, Stefanie Kirchen
  • Patent number: 10278950
    Abstract: The present invention provides a cannabis-based flavonoid pharmaceutical composition including any one or more selected from the group of Apigenin, Cannflavin A, Cannflavin B, Cannflavin C, Chrysoeriol, Cosmosiin and Flavocannabiside or their synthases, for the prevention and treatment of certain ocular diseases and related disorders.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: May 7, 2019
    Inventors: Henry I C Lowe, Ngeh J Toyang
  • Patent number: 10206861
    Abstract: The present disclosure relates to compositions containing a natural extract(s) and their fraction(s) and the use of such compositions for treatment of skin, hair and nail. For example, the present disclosure relates to compositions containing an aqueous extract of (i) Yacon leave, (ii) Amor Seco leave, or (iii) Porphyridium biomass, or a combination thereof and a pharmaceutically or cosmetically acceptable carrier use on hair skin and nails for cosmetic purposes.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: February 19, 2019
    Assignee: Seiberg Consulting, LLC
    Inventor: Miri Seiberg
  • Patent number: 10183922
    Abstract: The present invention relates to epoxy-tigliane compounds and their use in promoting wound healing. In particular embodiments, the epoxy-tigliane compounds are epoxy-tigliaen-3-one compounds. Methods of inducing or promoting wound healing as well as methods of reducing scarring and improving cosmetic outcomes upon healing of a wound are described. Compounds and compositions for use in wound healing are also described.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: January 22, 2019
    Assignee: QBiotics Limited
    Inventors: Paul Warren Reddell, Victoria Anne Gordon, Ryan Moseley, Robert Steadman, Rachael Louise Moses, Glen Mathew Boyle, Peter Gordon Parsons
  • Patent number: 10149808
    Abstract: The present disclosure relates to compositions and methods for providing full spectrum photo protection to skin, which includes protection from infrared (IR) radiation and/or visible light in addition to protection from UV radiation. The compositions typically include: (a) silymarin; (b) one or more antioxidants selected from the group consisting of ferulic acid, Vitamin C, polydatin, and hesperetin; (c) optionally, one or more solubilizers; and (d) a cosmetically acceptable carrier. The compositions are unique in that the combination of (a), (b), optional (c), and (d) alone, provide at least full spectrum protection from ultraviolet radiation (UV), visible light, and infrared radiation (IR). The composition can additionally, optionally, include one or more UV filters to further enhance protection from UV radiation.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: December 11, 2018
    Assignee: L'OREAL
    Inventors: Zhi Pan, Maolin Guo, Anne-Laure Suzanne Bernard
  • Patent number: 10039741
    Abstract: This disclosure relates generally to the treatment of lysosomal storage disorders. Specifically, the disclosure relates to a novel use of ? tocopherol in the treatment of diseases and conditions related to lysosomal storage disorders. Included in the present disclosure is a method for the modulation of cholesterol recycling. Further, the disclosure relates to conditions such as Niemann-Pick type C disease, Farber disease, Niemann-Pick type A disease, Wolman disease and Tay Sachs disease. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of ? tocopherol. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of ? tocopherol in combination with cyclodextrin to a patient in need thereof.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: August 7, 2018
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Wei Zheng, Juan Jose Marugan, Ke Liu, Noel Terrence Southall, Christopher P. Austin
  • Patent number: 10022351
    Abstract: The present invention relates to a compound of Formula 1, and an SIRT 1 activator including, as an active ingredient, derivatives thereof or pharmaceutically acceptable salts thereof. The present invention also relates to a composition including the SIRT 1 activator for detoxification, for the improvement of metabolic disorders, for the prevention or improvement of eye diseases, or the prevention or improvement of immune diseases.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: July 17, 2018
    Assignee: AMOREPACIFIC CORPORATION
    Inventors: Byung Gyu Kim, Hyun Woo Jeong, Su Kyung Kim, Si Young Cho, Chan Woong Park, Dae Bang Seo, Wan Gi Kim, Sang Jun Lee
  • Patent number: 10010098
    Abstract: A micronutrient dosage unit which comprises two or more micronutrients selected from vitamin A, vitamin B2, vitamin B6, vitamin B9, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K, calcium, magnesium, zinc, boron and chromium in one or more specified ratios.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: July 3, 2018
    Inventor: Ralph Brown
  • Patent number: 9999611
    Abstract: The present invention relates to a compound of Formula 1, and an SIRT 1 activator including, as an active ingredient, derivatives thereof or pharmaceutically acceptable salts thereof. The present invention also relates to a composition including the SIRT 1 activator for detoxification, for the improvement of metabolic disorders, for the prevention or improvement of eye diseases, or the prevention or improvement of immune diseases.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: June 19, 2018
    Assignee: AMOREPACIFIC CORPORATION
    Inventors: Byung Gyu Kim, Hyun Woo Jeong, Su Kyung Kim, Si Young Cho, Chan Woong Park, Dae Bang Seo, Wan Gi Kim, Sang Jun Lee
  • Patent number: 9895375
    Abstract: The present invention relates to a composition containing riboflavin and a sesamin-class compound(s). This composition may incorporate a sesamin-class compound(s) in such an amount that the proportion (weight ratio) of its total quantity to the total quantity of riboflavin taken as unity is no more than 4.5, and it has the advantage that the analgesic and anti-fatigue actions of riboflavin are synergistically improved by ingestion of riboflavin in combination with a sesamin-class compound(s). The composition of the present invention provides compositions, in particular, pharmaceuticals as well as foods and beverages that are safe to humans, animals, etc., and can therefore be ingested for a continued period, and which have far superior effects to those of conventional foods having an analgesic or anti-fatigue action.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: February 20, 2018
    Assignee: SUNTORY HOLDINGS LIMITED
    Inventors: Daisuke Takemoto, Norifumi Tateishi, Yoshiko Ono, Kayo Saito, Akifumi Maeda
  • Patent number: 9895323
    Abstract: Compositions having synergistic combinations of astaxanthin with a tomato extract lycopene, and optionally with carnosic acid and/or lutein. Compositions having synergistic combinations of the aforementioned compounds, which may be used, inter alia, to inhibit/suppress inflammation via the suppression of the expression of anti-inflammatory mediators or via the suppression of the secretion of anti-inflammatory mediators from macrophages at a site of inflammation.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: February 20, 2018
    Assignee: LYCORED LTD.
    Inventors: Rachel Levy, Nurit Hadad, Tanya Sedlov, Morris Zelkha
  • Patent number: 9789063
    Abstract: Described is a storage-stable dust-free homogeneous particulate formulation. The formulation consists of (a) at least one water-soluble Vitamin E-derivative, (b) at least one hydrophilic polymer, (c) optionally additional surface-active substances, and (d) optionally additional pharmaceutical additives. The sum of (a), (b), (c) and (d) equals 100% by weight of the formulation. The fines fraction with particle diameters of less than 100 ?m is less than 10% by weight. Describe also is a process for manufacturing the formulation, and use of the formulation as a solubilizing composition in pharmaceutical formulations.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: October 17, 2017
    Assignee: BASF SE
    Inventors: Felicitas Guth, Karl Kolter, Michael Schönherr, Michael Klemens Müller
  • Patent number: 9791359
    Abstract: A process for determining the incompatibility of crude mixtures (heavy, light) is based on the measurement of dynamic viscosity of crude mixtures using an electromagnetic viscometer having a mobile element (piston) move through the fluid to be measured at a constant force.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: October 17, 2017
    Assignee: INSTITUTO MEXICAN DEL PETROLEO
    Inventors: Marco Antonio Aquino Olivos, Adriana de Jesus Aguirre Gutierrez, Jose Luis Mendoza De La Cruz, Blanca Estela Garcia Flores, Jacinto Aguila Hernandez, Veronica Ramos Corzo, Juan Carlos Cedillo Ramirez, Oscar Alejandro Zamarripa Jimenez
  • Patent number: 9737606
    Abstract: This invention provides for biocompatible, biodegradable eye drop pharmaceutical formulations useful for the treatment of ocular indications. In particular, tocopherols and their esters of low water solubility, notably ?-tocopheryl acetate, are exceptional vehicles for biocompatible, nonirritating topical eye drop formulations that provide sustained release of active agents.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: August 22, 2017
    Assignee: Ramscor, Inc.
    Inventors: Vernon G. Wong, Louis L. Wood
  • Patent number: 9707162
    Abstract: Animate surface treatment compositions comprise (or in certain preferred embodiments may consist essentially of, or may consist of): a metal ion source material which releases copper ions and/or zinc ions into the treatment composition, in certain embodiments at least one alcohol which independently of other constituents present exhibits a microbicidal effect, in certain embodiments at least one quaternary ammonium compound which provides a microbicidal benefit, optionally but very preferably also at least one detersive surfactant, further optionally one or more further constituents which impart one or more advantageous technical or aesthetic benefits to the compositions, including one or more detersive surfactants, and water, wherein the compositions are at a pH such that the animate surface treatment compositions, exhibit a microbicidal or germicidal or antimicrobial effect on treated surfaces, which compositions are characterized in exhibiting a microbicidal benefit when tested against one or more challeng
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: July 18, 2017
    Assignee: RECKITT & COLMAN (OVERSEAS) LIMITED
    Inventor: Sarah Frances De Szalay
  • Patent number: 9702868
    Abstract: A method of determining relative polyphenol antioxidant levels in plant matter, particularly whole sorghum seeds, is carried out by combining a selected amount of solid plant matter to be evaluated with a solvent and a polyphenol extraction agent to form a stirrable mixture. The mixture is heated to approximately the boiling point of the solvent with agitation of the mixture for a period of at least 1½ hours. The heated mixture is filtered while the liquid is at a temperature of not more than 5° C. below the boiling point of the solvent to obtain an extractant solution filtrate. From this filtrate, a concentrated extractant solution is formed, cooled, and filtered to form a final filtrate. An analytical sample of this final filtrate is then introduced into a high performance liquid chromatography (HPLC) system to separate and determine the relative amounts of polyphenol antioxidants in the plant matter.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: July 11, 2017
    Assignee: Milo Insulation, LLC
    Inventor: Aubrie N. Starks
  • Patent number: 9687016
    Abstract: The present invention provides dietary formulations comprising polyunsaturated fatty acids and vitamin E. The present invention further provides methods of treating various conditions, generally involving administering to an individual in need thereof an effective amount of a subject dietary formulation.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: June 27, 2017
    Assignee: CHILDREN'S HOSPITAL & RESEARCH CENTER OAKLAND
    Inventor: Claudia R. Morris
  • Patent number: 9675541
    Abstract: A water-based pigmented preparation, its production and use and its application in a capillary storage system.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: June 13, 2017
    Assignee: Schwan-STABILO Cosmetics GmbH & Co. KG
    Inventors: Ursula Hunsinger, Zuhal Menguec, Marcus Schwertfeger
  • Patent number: 9675572
    Abstract: The invention encompasses intravenous pharmaceutical compositions containing omega-3 fatty acids and methods of treating traumatic brain injury, traumatic spinal cord injury and/or stroke using these pharmaceutical compositions.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: June 13, 2017
    Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY
    Inventor: Michael Lewis
  • Patent number: 9655847
    Abstract: A therapeutic liposome including a bilayer comprising at least one poly-unsaturated fatty acid (omega-3 fatty acid, omega-6 fatty acid, and omega-9 fatty acid), a beta-glucan, a cholesterol, and a doxorubicin. The liposome has a diameter of 100 nm to 1.5 ?m. The beta-glucan and the doxorubicin are encapsulated in the liposome and the cholesterol is integral to the bilayer of the liposome.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: May 23, 2017
    Assignees: National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center
    Inventors: Majed Abdulaziz Saleh Halwani, Moayad Abdulaziz Alhariri
  • Patent number: 9610234
    Abstract: Disclosed are active ingredient combinations of alkylamidothiazoles and one or more cosmetically or dermatologically acceptable preservatives.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: April 4, 2017
    Assignee: Beiersdorf AG
    Inventors: Tobias Mann, Cathrin Scherner, Ludger Kolbe, Jan Batzer
  • Patent number: 9579274
    Abstract: A formulation for a stable ascorbic acid composition which, in a simplified form, is comprised of ascorbic acid in solution with a hygroscopic compound (i.e., a substance with the ability to attract water molecules from the surrounding environment through either absorption or adsorption). Also disclosed herein are methods for the production of such compounds and methods of using such compounds in the prevention, inhibition and treatment of striae gravidarum, radiation dermatitis, rhytids, lentigoes, dyschromia, sun-damage induced hyperpigmentation, cellulite, scars and purpura, among other skin diseases or conditions.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: February 28, 2017
    Inventor: David L. Kaplan
  • Patent number: 9518038
    Abstract: The present invention relates to a compound as represented by formula (I), which is a condensation product of a theanine derivative and a carboxylic acid coumarin derivative, compounds as represented by formula (II) and formula (III), both of which are intermediates of the condensation product, a method for preparing these compounds, a pharmaceutical composition comprising the compounds, and a use thereof in preparing a medicament for prevention and treatment of tumors, inflammation, cardiovascular diseases, immune deficiency diseases and the like.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: December 13, 2016
    Assignee: Shandong Yingdong Yinghao Biotechnology, Inc.
    Inventors: Guoying Zhang, Ying Zhang, Benhao Wu, Guohua Zhang
  • Patent number: 9512098
    Abstract: The invention is generally directed to a process of producing purified gamma- and/or delta-tocotrienols from tocol-rich oils or distillates, such as rice bran oil deodorizer distillate or palm oil. The process produces a gamma- and/or delta-tocotrienol-rich fraction in a high proportion of ?-T3 and/or ?-T3 while minimizing the presence of alpha isomers from the tocol-rich oil or distillate. The ?-T3- and/or ?-T3-rich fraction comprises about 95% of total tocols, with the process yielding ?-T3 in approximately 10% and ?-T3 in about 3%, with each having purity in excess of approximately 95%. The process utilizes flash or other low pressure chromatography to provide rapid isolation of gamma- and/or delta-tocotrienol from the tocol-rich oil or distillate.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: December 6, 2016
    Assignee: Board of Trustees of the University of Arkansas
    Inventor: Luke Howard
  • Patent number: 9480654
    Abstract: The invention relates to novel particulate drug-delivery systems based on a polymer support containing at least one linear, branched or cross-linked polymer in a fraction of over 50 percent by weight in relation to the total weight of the support. The system is characterized in that at least one signal substance for transport through a biological barrier and at least one active ingredient are stored, the support, signal substance and active ingredient having no covalent links and no active-ingredient specific and signal substance specific coordinative links between one another.
    Type: Grant
    Filed: October 10, 2012
    Date of Patent: November 1, 2016
    Assignee: EVONIK ROEHM GmbH
    Inventors: Matthias Seiler, Norbert Windhab, Manfred Stickler, Hans-Ulrich Petereit
  • Patent number: 9468609
    Abstract: This invention is directed to compositions having synergistic combinations of astaxanthin with a tomato extract lycopene, and optionally with carnosic acid and/or lutein. More specifically, the present invention provides compositions having synergistic combinations of the aforementioned compounds, which may be used, inter alia, to inhibit/suppress inflammation via the suppression of the expression of anti-inflammatory mediators or via the suppression of the secretion of anti-inflammatory mediators from macrophages at a site of inflammation.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 18, 2016
    Assignee: LYCORED LTD.
    Inventors: Rachel Levy, Nurit Hadad, Tanya Sedlov, Morris Zelkha
  • Patent number: 9464016
    Abstract: Methods of treating or suppressing oxidative stress disorders affecting normal electron flow in the cells, including mitochondrial diseases, impaired energy processing disorders, neurodegenerative diseases, diseases of aging and diseases caused by reactive oxygen species are disclosed, as well as compounds useful in the methods of the invention, such as such as catechol or ortho-quinone derivatives of Formula (I).
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: October 11, 2016
    Assignee: EDISON PHARMACEUTICALS, INC.
    Inventors: Paul Mollard, Gloria Pfister
  • Patent number: 9427404
    Abstract: Disclosed herein is a microemulsifying system consisting essentially of coconut oil and Polysorbate 80 in a specific weight ratio. Also disclosed herein are microemulsion preconcentrates and microemulsions that contain a lipophilic functional ingredient formulated with the microemulsifying system. Processes for preparing the microemulsion preconcentrates and microemulsions are also disclosed herein.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: August 30, 2016
    Assignee: Food Industry Research and Development Institute
    Inventors: Jun-Po Sun, Tsung-Chieh Chiu, Jung-Ting Hsieh, Jinn-Tsyy Lai, Chii-Cherng Liao
  • Patent number: 9427473
    Abstract: The present invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil, (B) polyethylene glycol monostearate, and (C) at least one member selected from the group consisting of sesame oil, castor oil, vitamin A, and chlorobutanol.
    Type: Grant
    Filed: November 29, 2013
    Date of Patent: August 30, 2016
    Assignee: ROHTO PHARMACEUTICAL CO., LTD.
    Inventors: Ryo Komurasaki, Yoko Mizutare, Atsuko Nakata
  • Patent number: 9345683
    Abstract: The present invention relates to a stable oral pharmaceutical composition with improved solubility and bioavailability; comprising a taxoid, a solubilizer, a stabilizing agent, a surfactant(s), a solvent(s), and an oil wherein the concentration of taxoid is in the range of 0.1 to 10%.
    Type: Grant
    Filed: November 5, 2011
    Date of Patent: May 24, 2016
    Assignee: Cadila Pharmaceuticals Limited
    Inventors: Bakulesh Mafatlal Khamar, Ashish Premkumar Gogia, Ritu Nitin Laddha, Imran Ahmed Khan, Vandana Bharat Patravale, Indravadan Ambalal Modi
  • Patent number: 9345685
    Abstract: The present invention relates to compositions comprising a combination of PKC activators and PKC inhibitors and methods to modulate ?-secretase activity; improve or enhance cognitive ability; and or reduce neurodegeneration in individuals suffering from diseases that impair cognitive ability, particularly Alzheimer's Disease. The invention also relates to methods for improving or enhancing cognitive ability. The present invention also provides methods for increasing the generation of non-amyloidogenic soluble APP (sAPP) comprising the activation of protein kinase C (PKC) in the brain and inhibiting PKC in peripheral tissues. Macrocyclic lactones (i.e. bryostatin class and neristatin class) are preferred PKC activators and Vitamin E is a preferred PKC inhibitor for use in the inventive composition.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: May 24, 2016
    Assignee: Blanchette Rockefeller Neuroscience Institute
    Inventor: Daniel Alkon
  • Patent number: 9271956
    Abstract: A composition includes dihydroquercetin, ?-tocopherol and bisabolol. The use of the composition in a cosmetic method for limiting, alleviating and/or preventing cutaneous discomfort, especially cutaneous discomfort induced by a disease or induced by a therapy, a radiotherapy treatment and/or chemotherapy treatment, and the process of manufacturing the composition are also described.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: March 1, 2016
    Assignee: BIONOOX SUISSE SA
    Inventor: Christian Auclair
  • Patent number: 9254304
    Abstract: The present invention relates to a dietary supplement composition made of: linolenic expeller pressed soybean oil in the range of 65%-85%, Omega 3 (18/12) fish oil 15%-35%, 1%-20% alpha-tocopherol, and 7.5%-15% acai berry powder and a method to use this composition to supplement the diet of a domestic animal, such as a canine or an equine.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: February 9, 2016
    Assignee: O3 Animal Health, LLC
    Inventor: Murray Fulgham
  • Patent number: 9248155
    Abstract: The present invention relates to a dietary supplement composition made of: linolenic expeller pressed soybean oil in the range of 65%-85%, Omega 3 (18/12) fish oil 15%-35%, and 1%-20% alpha-tocopherol and a method to use this composition to supplement the diet of a domestic animal, such as a canine or an equine.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: February 2, 2016
    Assignee: O3 Animal Health, LLC
    Inventor: Murray Fulgham
  • Patent number: 9199101
    Abstract: The invention relates to the cosmetic use of a peptide hydrolysate of pea (Pisum sativum L.), as skin-moisturizing active agent. The invention also relates to the use of a cosmetic composition comprising an effective amount of active agent according to the invention in a physiologically acceptable medium, for preventing dryness of the skin or restoring moisturization of the skin. The invention also relates to the use of this novel active agent for preparing a pharmaceutical, in particular dermatological, composition intended for treating pathological dryness of the skin.
    Type: Grant
    Filed: April 14, 2011
    Date of Patent: December 1, 2015
    Assignee: ISP INVESTMENTS INC.
    Inventors: Claude Dal Farra, Nouha Domloge, Jean-Marie Botto
  • Patent number: 9144566
    Abstract: The present invention provides for compositions, medicaments, and methods for treating or alleviating the symptoms of dry eye syndrome or chronic dry eye. More specifically, the present embodiments provide for medicaments consisting of tocopherol or tocotrienol eyedrops. A single topical administration of tocopherol or tocotrienol eyedrops in the eyes of a subject suffering from dry eye alleviates symptoms for at least one day. In particular, the eyedrop medicament consists of ?-tocopheryl acetate; ?-tocopheryl acetate and about 0.5% aqueous component; or ?-tocopheryl acetate, about 2.5% tocopherol emulsifier, and about 20% to about 30% aqueous excipient.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: September 29, 2015
    Assignee: Ramscor, Inc.
    Inventors: Vernon G. Wong, Louis L. Wood
  • Patent number: 9066904
    Abstract: A composition useful for maintaining healthy levels of testosterone in men and women. The composition includes essential oils from a tree of the genus Picea or a product of this oil. The essential oil product can specifically come from essential oil from the plant Picea pungens, commonly referred to as Blue Spruce. Also disclosed is a method for maintaining healthy levels of testosterone in men and women utilizing the composition. In some implementations, the composition is a pharmaceutical composition that further includes a penetration enhancer. A method for utilizing the pharmaceutical composition for treating hypogonadism is also disclosed.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: June 30, 2015
    Assignee: Young Living Essential Oils, LC
    Inventor: D. Gary Young
  • Patent number: 9044451
    Abstract: This disclosure relates generally to the treatment of lysosomal storage disorders. Specifically, the disclosure relates to a novel use of delta tocopherol in the treatment of diseases and conditions related to lysosomal storage disorders. Included in the present disclosure is a method for the modulation of cholesterol recycling. Further, the disclosure relates to conditions such as Niemann-Pick type C disease, Farber disease, Niemann-Pick type A disease, Wolman disease and Tay Sachs disease. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of delta tocopherol. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of delta tocopherol in combination with cyclodextrin to a patient in need thereof.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: June 2, 2015
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Wei Zheng, Juan Jose Marugan, Ke Liu, Noel Terrence Southall, Christopher P Austin
  • Publication number: 20150148317
    Abstract: A drug delivery system is provided for treatment of oxidative stress. The drug delivery system can include a therapeutic agent and a matrix. The therapeutic agent can include an antioxidant or steroid. The matrix can include a hydrogel, particle, microparticle, or nanoparticle. A method of treating injury, including peripheral nerve injury or spinal cord injury, is also provided. The method includes injecting the drug delivery system at the site of injury.
    Type: Application
    Filed: November 26, 2014
    Publication date: May 28, 2015
    Applicants: InVivo Therapeutics Corporation, Massachusetts Institute of Technology
    Inventors: Christopher D. Pritchard, Robert S. Langer, Francis M. Reynolds, Eric J. Woodard
  • Patent number: 9040066
    Abstract: This invention is based upon the discovery that a mixture of ethyl lactate and isoamyl lactate can be used to improve the penetration of active ingredients in skin care formulations through the outer layers of the stratum corneum and viable epidermis and into the dermis layer of the skin structure. The present invention more specifically discloses a method of rejuvenating skin comprising topically applying a topical formulation to the skin, wherein the topical formulation is comprised of ascorbic acid, an amino acid selected from the group consisting of phenylalanine and tyrosine, a non-toxic zinc salt, carnosic acid, ?-tocopherol, 0.01 weight percent to 20 weight percent of a mixture of ethyl lactate and isoamyl lactate, wherein the weight ratio of the ethyl lactate to the isoamyl lactate is within the range of 1:10 to 20:1, and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: May 26, 2015
    Assignee: Ad Lunam Labs, Inc.
    Inventors: William H. Beeson, Alvin T. Rockhill
  • Publication number: 20150139973
    Abstract: The present invention relates to an ophthalmological vehicle system for the permeation and/or for the active substance transport of ophthalmological active substances through the cornea and/or the sclera of the eye of mammals. This vehicle system assists the transport of the active substances through the cornea and/or the sclerotic tissue of the eye. The vehicle system is suitable for the prophylaxis and/or treatment of diseases of the front and/or back portion of the eye. Likewise, the present invention relates to an ophthalmological kit, comprising a special ophthalmological composition and also, as separate formulation, an ophthalmological active substance.
    Type: Application
    Filed: May 14, 2013
    Publication date: May 21, 2015
    Inventors: Ute Steinfeld, Frank Holzer, Hyeck Hee Lee, Markus Mahler
  • Publication number: 20150139938
    Abstract: The present invention provides methods of promoting arteriogenesis in a subject. Embodiments include methods comprising: administering an effective dose of tocotrienol to the subject; causing an increase in Tissue Inhibitor of Metalloproteinase Metallopeptidase Inhibitor 1 (TIMP1) in vessels of cerebrovascular collateral circulation in the subject; attenuating the activity of Matrix Metalloproteinase-2 (MMP2); thereby promoting arteriogenesis.
    Type: Application
    Filed: June 7, 2013
    Publication date: May 21, 2015
    Applicant: Ohio State Innovation Foundation
    Inventors: Chandan Sen, Cameron Rink, Sashwati Roy, Greg Christoforidis
  • Patent number: 9034919
    Abstract: This invention relates generally to the field of compositions for use as nutraceuticals, food additives or adjuncts to conventional drug therapies. In particular, the invention relates to compositions derived from natural oil sources which can be used for effective and inexpensive treatment of cardiovascular diseases, hypercholesterolemia, diabetes, cerebrovascular disease, neurological disorders, or liver abnormalities.
    Type: Grant
    Filed: April 18, 2006
    Date of Patent: May 19, 2015
    Inventors: Aravind Cherukuri, Reddy Sastry V. Cherukuri, Rukmini C. Cherukuri, Kartik Natarajan
  • Patent number: 9034383
    Abstract: The present invention provides nanoparticulate policosanol, and octacosanol formulations including these particles, as a well as methods of using the particles and formulations for treatment and prophylaxis of various diseases and conditions.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: May 19, 2015
    Assignee: NanoRx, Inc.
    Inventor: Palayakotai R. Raghavan
  • Publication number: 20150118298
    Abstract: Described herein are pharmaceutical compositions comprising polyunsaturated fatty acids and methods of manufacturing the same. In particular, described herein are pharmaceutical compositions comprising soft enteric capsules comprising omega-3 polyunsaturated fatty acids. The oral pharmaceutical compositions described herein are useful as nutritional supplements or for the treatment of cardiovascular-related diseases, such as hyper dyslipidemia and high triglyceride levels.
    Type: Application
    Filed: October 29, 2014
    Publication date: April 30, 2015
    Inventors: Peijin Zhang, Aqeel A. Fatmi
  • Patent number: 9011915
    Abstract: This invention provides for biocompatible and biodegradable syringeable liquid, implantable solid, and injectable gel pharmaceutical formulations useful for the treatment of systemic and local disease states.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: April 21, 2015
    Assignee: Ramscor, Inc.
    Inventors: Vernon G. Wong, Louis L. Wood
  • Publication number: 20150094292
    Abstract: Activated fatty acids, topical compositions including activated fatty acids and methods for using activated fatty acids to treat a variety of diseases.
    Type: Application
    Filed: December 8, 2014
    Publication date: April 2, 2015
    Inventor: Raymond A. Miller
  • Publication number: 20150086625
    Abstract: Activated fatty acids, nutraceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.
    Type: Application
    Filed: December 8, 2014
    Publication date: March 26, 2015
    Inventor: Raymond A. Miller