Tocopherols (e.g., Vitamin E, Etc.) Patents (Class 514/458)
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Publication number: 20110150988Abstract: A human or animal dietary supplement composition comprising one or more long chain (C24-C36) primary alcohols (policosanols) dispersed in food-grade oils or fats where the policosanol particle size is substantially less than ten (10) microns. The composition (Nanocosanolâ„¢) is effective and convenient for supporting blood lipid health.Type: ApplicationFiled: March 3, 2011Publication date: June 23, 2011Applicant: U.S. NUTRACEUTICALS, LLC. d/b/a Valensa InternationalInventors: David A. EVANS, W. Stephen Hill
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Publication number: 20110150968Abstract: A strip, which is both edible and dissolvable, is provided comprising a film and a dosage of at least 2% of the reference daily intake (RDI) of at least one dietary supplement for malnutrition or to prevent/treat alcohol induced hangovers. A method for treating malnutrition and/or preventing and treating alcohol-induced hangovers using a dissolvable orally administered strip.Type: ApplicationFiled: June 18, 2010Publication date: June 23, 2011Inventor: Alessandra Grassi
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Publication number: 20110150944Abstract: The present invention relates to structured triglycerides, to parenteral nutrition emulsions of the same, and uses thereof. In particular, the invention relates to structured triglycerides that include at least one medium chain C6-C12 fatty acid and at least one fatty acid selected from long chain C14-C18 or very long chain C20-C22 fatty acids. Preferably, each fatty acid is present in a predetermined position of the glycerol backbone. The parenteral nutrition emulsions are particularly useful for nourishing preterm- and term-infants, children, critically ill patients, and cancer patients.Type: ApplicationFiled: March 2, 2011Publication date: June 23, 2011Inventors: Geila Rozen, Irit Shochat
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Patent number: 7964587Abstract: Anti-inflammatory compositions include medicaments comprising predetermined amounts of a phytyl substituted chromanol and a prostaglandin E2 inhibitor, wherein: said medicament is in unit dosage form suitable for pharmaceutical administration; said phytyl substituted chromanol is a gamma-tocopherol, delta-tocopherol, gamma-tocotrienol or delta-tocotrienol; said PGE2 inhibitor is a non-steroidal anti-inflammatory drug or an omega-3 fatty acid, such as docosahexaenoic acid and eicosapentaenoic acid.Type: GrantFiled: June 22, 2005Date of Patent: June 21, 2011Assignee: Children's Hospital & Research Center at OaklandInventors: Bruce N. Ames, Qing Jiang
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Publication number: 20110142899Abstract: SUMMARY The present invention refers to new active nanocomposite materials, comprising a matrix and additives. The present invention also describes a process for obtaining these nanocomposite materials and their use in various industry sectors.Type: ApplicationFiled: June 25, 2009Publication date: June 16, 2011Applicant: NANOBIOMATTERS, S.L.Inventors: Jose Maria Lagaron Abello, Maria Antonieta Busolo Pons, Maria Eugenia Nunez Calzado
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Patent number: 7959905Abstract: A dermatological composition which may be used for the topical treatment of the skin, hair, or nails of mammals, comprising tamanu oil, an unsaturated fatty acid, and arnica oil, optionally including Vitamins E and A. The dermatological composition may be combined with other components to form a shampoo, conditioner, lotion, cream, spray, salve, or other cosmetic product in liquid, paste, or powder form.Type: GrantFiled: June 9, 2006Date of Patent: June 14, 2011Assignee: T.F.H. Publications, Inc.Inventors: Glen S. Axelrod, Ajay Gajria
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Patent number: 7951845Abstract: A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is equal to or greater than a sum of the effect of the individual components. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, a donor antioxidant, a third antioxidant, and a vasodilator. A method of treating hearing loss includes the step of internally administering the composition including a biologically effective amount of the at least one scavenger of singlet oxygen, the donor antioxidant, the third antioxidant, and the vasodilator to a mammal within three days of trauma to a middle or inner ear of the mammal.Type: GrantFiled: January 17, 2007Date of Patent: May 31, 2011Assignee: The Regents of the University of MichiganInventors: Josef Miller, Colleen LePrell, Jochen Schacht, Diane Prieskorn
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Patent number: 7951847Abstract: Provided are methods of treating HIV patients by administering to the patient a nutrient composition and at least one anti-retrovial drug. The method results in an increase in the patient's CD4+ cell count by at least 25% during a treatment period. The nutrient composition includes alpha lipoic acid; acetyl L-carnitine; N-acetyl-cysteine; zinc; selenium; vitamin C; bioflavinoid complex; vitamin E; one or more antioxidants selected from co-enzyme Q10 and glutathione; and one or more vitamins or minerals selected from beta-carotene, vitamin A, vitamin B1, vitamin B2, vitamin B6, niacinamide, calcium pantothenate, folic acid, vitamin B12, copper, manganese, chromium, and molybdenum.Type: GrantFiled: March 7, 2008Date of Patent: May 31, 2011Assignee: K-PAX Vitamins, Inc.Inventor: Jon D. Kaiser
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Publication number: 20110117194Abstract: The present invention provides a pharmaceutical formulation containing an angiotensin-II receptor blocker and a release-control material as a pharmacologically active ingredient and a pharmaceutical formulation comprising an immediate-release compartment and an extended-release compartment. The immediate-release compartment contains an agent as a pharmacologically active ingredient for preventing and inhibiting hepatitis and the extended-release compartment has an angiotensin-II receptor blocker as a pharmacologically active ingredient. The formulation of the present invention maximizes the effectiveness on pharmacologically and clinically lowering blood pressure and preventing complications when taking the formulation, helps to avoid interaction with a drug which is metabolized by the same enzyme in the liver, and prevents and inhibits the incidence of drug-induced hepatitis which is caused by drug administration for a long time.Type: ApplicationFiled: April 28, 2009Publication date: May 19, 2011Applicant: HANALL BIOPHARMA CO., LTD.Inventors: Sung Wuk Kim, Sung Soo Jun, Young Gwan Jo, Ja Seong Koo, Ah Ram Lee, Jae Woon Son, Jeong Taek Kim
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Publication number: 20110110913Abstract: A method of inducing NAD+ synthesis in a subject. The method comprises administering to the subject a therapeutically effective amount of resveratrol or a functionally equivalent analogue or derivative thereof. NAD+ synthesis increases the activity of Poly(ADP-ribose) polymerase (PARP) enzymes and sirtuin enzymes. The PARP enzyme is PARP-1 or PARP-2 and the sirtuin enzyme is selected from the group consisting of SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6 and SIRT7.Type: ApplicationFiled: March 3, 2009Publication date: May 12, 2011Inventors: Ross Stewart Grant, Nady Braidy, Gilles Guillemin, George Smythe
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Publication number: 20110111055Abstract: The present invention provides improved dietary supplements and methods for alleviating the symptoms of dry eye. The dietary supplements of the invention contain omega-3 fatty acids and flavonoids.Type: ApplicationFiled: November 8, 2010Publication date: May 12, 2011Applicant: ALCON RESEARCH, LTD.Inventor: John C. Lang
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Publication number: 20110104257Abstract: Methods of determining a subjects ototoxicity risk from administration of platinum-coordinating compounds having an ototoxicity risk, methods of administering a platinum-coordinating compound having an ototoxicity risk and oligonucleotides, peptide nucleic acids, arrays and addressable collections for performing embodiments of the methods are provided herein.Type: ApplicationFiled: April 14, 2009Publication date: May 5, 2011Inventors: Michael R. Hayden, Bruce Carleton, Colin Ross
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Publication number: 20110105601Abstract: The present invention relates to a composition comprising (i) choline and (ii) a compound selected from the group consisting of palmitate, vitamin C and vitamin E for use in treating or preventing metabolic stress-induced lung injury and a method for increasing physical capacity of mammalian livestock comprising administering to the mammalian livestock the above composition.Type: ApplicationFiled: September 28, 2010Publication date: May 5, 2011Applicant: nutri-fit GmbH & Co. KGInventor: Michael Sobirey
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Publication number: 20110098229Abstract: Provided herein are methods of improving one or more symptoms of a dermatological condition in a patient. The methods comprise topically administering a topical composition to the patient comprising a branched chain amino acid, and an enzyme activator. Also provided are kits comprising the topical composition and optionally a topical steroid.Type: ApplicationFiled: October 28, 2009Publication date: April 28, 2011Inventor: Harbhajan S. Paul
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Publication number: 20110086890Abstract: The present invention relates to a liquid pest control system that includes a synthetic pyrethroid as a pest control active ingredient and an agent selected from the group consisting of purified diethylene glycol monoethyl ether, tocopherol nicotinate and tocopherol succinate, and combinations thereof, to reduce or eliminate paraesthesia of the synthetic pyrethroid. The system releases the synthetic pyrethroid efficiently and uniformly. The pest control system is less irritating to the animal's skin as compared to prior art systems, particularly to the small breeds of dogs. The system is useful for making liquid spot-on treatments, sprays and the like.Type: ApplicationFiled: September 4, 2010Publication date: April 14, 2011Applicant: REDLINE PRODUCTS, INC.Inventor: Donald W. Kelley
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Publication number: 20110087152Abstract: Compositions and method for augmenting tissue after delivery to localized area. The compositions include a hydrogel and a dermal filler. The hydrogel can polymerize and/or crosslink upon a first trigger event. The dermal filler can also optionally crosslink upon a second trigger event.Type: ApplicationFiled: May 7, 2010Publication date: April 14, 2011Inventors: Nathaniel E. David, Jennifer Elisseeff
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Patent number: 7923469Abstract: Compositions for caring for contact lenses and eyes include a liquid aqueous medium and a vitamin derivative component present in an amount effective as a surfactant in the composition. The compositions can be used to clean, soak, re-wet and, with the inclusion of a disinfectant, disinfect contact lenses. In addition, the compositions are effective as artificial tears and eye wash solutions. Methods for contact lens care and eye care are also disclosed.Type: GrantFiled: April 24, 2002Date of Patent: April 12, 2011Assignee: Allergen, Inc.Inventors: Stanley Huth, Richard Chadwick, Gerry Franco
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Publication number: 20110081330Abstract: The present invention relates to compositions containing plant gums and one or more fat-soluble active ingredients, wherein the composition comprises less than 40 weight-% oil, based on the total composition in dry matter. These compositions can be used for the enrichment, fortification and/or coloration of food beverages, animal feed, cosmetics or pharmaceutical compositions. The present invention also refers to the preparation of such compositions. The present invention furthermore refers to a process for the manufacture of a beverage by mixing the compositions with ingredients of beverages. The present invention also refers to beverages obtainable by this process.Type: ApplicationFiled: June 3, 2009Publication date: April 7, 2011Inventors: Andrea Hitzfeld, Bruno H. Leuenberger, Olivia Vidoni
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Patent number: 7919526Abstract: The present invention relates to structured triglyceride, to parental nutrition emulsions comprising same, and use thereof. In particular, the invention relates to structured triglycerides comprising at least one medium chain C6-C12 fatty acid and at least one fatty acid selected from the group consisting of long chain C14-C18 or very long chain C20-C22 fatty acids, preferably each fatty acid is present in a predetermined position of the glycerol backbone. The parenteral nutrition emulsions are particularly useful for nourishing preterm- and term-infants, children, critically ill patients, and cancer patients.Type: GrantFiled: March 3, 2005Date of Patent: April 5, 2011Assignee: HTL High-Tech Lipids Ltd.Inventors: Geila Rozen, Irit Shochat
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Patent number: 7919525Abstract: The present invention relates to methods for the prevention and treatment of a mammal from radiation-induced internal injury using ?-tocotrienol, ?-tocopherol succinate or ?-tocotrienol succinate. Specifically, the present invention relates to methods for preventing and treating radiation-induced injuries in a mammal by (1) subcutaneous, intramuscular, intraperitoneal, or intravascular injection of a therapeutically effective amount of ?-tocotrienol; or (2) oral administration of a therapeutically effective amount of ?-tocopherol succinate or ?-tocotrienol succinate or both.Type: GrantFiled: February 17, 2004Date of Patent: April 5, 2011Assignee: Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.Inventors: K. Sree Kumar, Venkataraman Srinivasan, Thomas M. Seed, Andreas Papas
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Publication number: 20110059164Abstract: An encapsulated material containing an oxidation-sensitive core is covered by at least a dried synthetic organelle layer and optional additional ingredients in the organelle layer or additional layers. By using microencapsulation to mimic or otherwise adapt the storage concepts used by seeds to protect triacylglycerol cores, oxidatively unstable materials may be provided with a synthetic, seed-like oxygen-resistant protective barrier and rendered less susceptible to oxidative degradation.Type: ApplicationFiled: January 2, 2009Publication date: March 10, 2011Inventors: William A. Hendrickson, John M. Finney, Olaf C. Moberg, Christopher J. Rueb, Robert G. Bowman, Chetan S. Rao, Nita M. Bentley
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Publication number: 20110059898Abstract: This invention relates to anti-cancer compounds and to methods for treating or preventing cancer. In particular, the invention concerns pro-oxidant anti-cancer compounds, such as pro-oxidant forms of vitamin E, that selectively interact with complex II of the mitochondrial respiratory chain of cancerous cells, generate reactive oxygen species and induce apoptosis of those cells.Type: ApplicationFiled: September 17, 2007Publication date: March 10, 2011Inventors: Stephen John Ralph, Jiri Neuzil
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Publication number: 20110052511Abstract: The present invention is directed to the use of a compound selected from the group consisting of ?-carotene, lutein, lycopene and ?-cryptoxanthin, and mixtures thereof and combinations thereof with CoQ-10 for maintaining the energy metabolism, the energy flow and/or the energy production in skin or of skin of animals including humans, for maintaining the respiratory function of the skin of animals including humans, for energizing the skin, maintaining and supporting the radiance and natural glow of the skin of animals including humans and for promoting a healthy appearance of the skin of animals including humans for preventing UV-A radiation-induced mtDNA mutagenesis in skin of animals including humans, as well as for the manufacture of a composition, preferably an orally applicable composition, for these uses and the corresponding methods.Type: ApplicationFiled: August 23, 2010Publication date: March 3, 2011Applicant: DSM IP ASSETS B.V.Inventors: Regina Goralczyk, Karin Wertz
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Publication number: 20110052704Abstract: Compositions containing tocotrienol, non-tocotrienol lipids and surface active agents; compositions containing particles having a statin and a tocotrienol wherein the particle size is less than 1000 nm; and microemulsions containing a statin and a tocotrienol are disclosed. Methods relating to the creation of such compositions and the use of such compositions are further disclosed.Type: ApplicationFiled: September 1, 2010Publication date: March 3, 2011Applicant: First Tech International LimitedInventors: Sami Mahmoud Nazzal, Paul W. Sylvester
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Publication number: 20110052680Abstract: An encapsulated material containing an oxidation-sensitive core is covered by at least a dried phospholipid layer, and contains at least one phytosterol in the core, the phospholipid layer or in a further layer or layers. By using microencapsulation, oxidatively unstable materials may be provided with a synthetic protective barrier and rendered less susceptible to oxidative degradation.Type: ApplicationFiled: January 2, 2009Publication date: March 3, 2011Inventors: William A. Hendrickson, John M. Finney, Olaf C. Moberg, Christopher J. Rueb, Robert G. Bowman, Chetan S. Rao, Nita M. Bentley
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Publication number: 20110052694Abstract: Described herein are microneedle drug delivery systems comprising a pharmaceutical compositions comprising pharmaceutically active agents (e.g., cannabidiol and prodrugs of cannabidiol) and microneedle arrays suitable for local and systemic delivery of the active agent to a mammal. Also described herein are methods of using a microneedle transdermal or topical drug delivery systems comprising pharmaceutical compositions, comprising cannabidiol and prodrugs of cannabidiol, and microneedle arrays in the treatment disease, including pancreatitis and pancreatic cancer.Type: ApplicationFiled: August 31, 2010Publication date: March 3, 2011Applicant: ALLTRANZ INC.Inventors: Audra Lynn Stinchcomb, Stan Lee Banks, Miroslaw Jerzy Golinski, Jeffery Lynn Howard, Dana Carmel Hammell
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Publication number: 20110045041Abstract: The present invention relates to methods and compositions for the delivery of cosmetics and medicants. In some embodiments, the invention relates to compositions comprising both hydrophobic and hydrophilic polymers. In preferred embodiments, the invention relates to the delivery of peptides, small molecules and other bioactive compounds using the compositions and methods disclosed herein.Type: ApplicationFiled: March 26, 2009Publication date: February 24, 2011Inventors: Nevenka Golubovic-Liakopoulos, Bhavdeep Shah, Erik Andersen
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Publication number: 20110046216Abstract: Stable liquid compositions containing the oxidized form of vitamin C known as dehydroascorbic acid are provided. The compositions comprise dehydroascorbic acid and a pharmacologically acceptable liquid organic polyol solvent for said dehydroascorbic acid, wherein said polyol solvent comprises about 50% or greater of the total weight of said composition. The compositions are useful as dietary supplements, skin-enhancers, concentrates, or research solutions.Type: ApplicationFiled: May 25, 2010Publication date: February 24, 2011Inventors: DOUGLAS Q. KITT, JAY P. KITT
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Publication number: 20110046156Abstract: Compositions and methods are provided for prophylactic or therapeutic treatment of a mammal for hearing or balance impairments involving neuronal damage, loss, or degeneration, by administration of a therapeutically effective amount of a redox-active therapeutic. Also provided are improved compositions and methods for treatments requiring administration of a pharmaceutical having an ototoxic side-effect in combination with a therapeutically effective amount of a redox-active therapeutic to treat the ototoxicity.Type: ApplicationFiled: March 4, 2009Publication date: February 24, 2011Inventor: Guy M. Miller
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Publication number: 20110044908Abstract: The present invention provides methods for treating or limiting development of age-related macular degeneration, as well as methods for identifying compound suitable for such use.Type: ApplicationFiled: April 17, 2009Publication date: February 24, 2011Applicant: Arizona Board of Regents, a body Corporate of the State of Arizona, acting for and on behalf of theInventors: Brian McKay, John A. Martens
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Publication number: 20110038940Abstract: A pulverulent composition includes less than 96% in weight, preferably from 10 to 80%, and more preferably from 20% to 70%, of at least a vitamin having a solubility lower than 20 g/L and preferably 1 g/L and more preferably lower than 500 mg/L in aqueous media, the pulverulent composition being stable on storage and having instantaneous dispersion and solubility properties in aqueous solutions.Type: ApplicationFiled: February 6, 2009Publication date: February 17, 2011Applicant: INNOV'IAInventor: Alain Grizeau
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Publication number: 20110038905Abstract: It is an object of the present invention to provide a skin anti-aging agent for external use which comprises highly safe protein nanoparticles having high transparency due to the small particle size and high permeability into skin. The present invention provides a skin anti-aging agent for external use, which comprises protein nanoparticles containing an active ingredient.Type: ApplicationFiled: October 28, 2010Publication date: February 17, 2011Applicant: FUJIFILM CorporationInventors: Makiko AIMI, Kazutaka Ogiwara, Takuo Amano
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Patent number: 7888391Abstract: The present invention relates to the use of polyunsaturated fatty acids and one or more components which have a beneficial effect on total methionine metabolism selected from the group consisting of vitamin B12 and precursors thereof, vitamin B6 and derivatives thereof, folic acid, zinc and magnesium, in the manufacture of a preparation for improving the action of receptors. This preparation is advantageously applied in patients suffering from Parkinson's disease, Huntington's chorea, epilepsy, schizophrenia, paranoia, depression, sleep disorders, impaired memory function, psychoses, dementia and ADHD.Type: GrantFiled: March 10, 2008Date of Patent: February 15, 2011Assignee: N.V. NutriciaInventors: Amanda Johanne Kiliaan, Robert Johan Joseph Hageman
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Publication number: 20110033531Abstract: An orally administered fatty acid composition for the treatment of cardiovascular diseases, and a method of treating same, are provided. The compound includes 5Z,8Z,11Z,14Z,17Z-eicosapentaenoic ethanolamide (EPA ethanolamide), 4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic ethanolamide (DHA ethanolamide), and at least one tocotrienol. The EPA ethanolamide and the DHA ethanolamide are preferably each substantially in a range of 100-900 mg per dosage form. The at least one tocotrienol is substantially in a range of 10-500 mg per dosage form. The at least one tocotrienol includes at least one of ?-tocotrienol, ?-tocotrienol, ?-tocotrienol, or ?-tocotrienol and is preferably substantially tocopherol-free. The composition may take the form of a medical food or a pharmaceutical preparation. A preferred formulation of the composition includes approximately 525 mg EPA ethanolamide, approximately 315 mg DHA ethanolamide, and approximately 50 mg ?-tocotrienol.Type: ApplicationFiled: August 9, 2010Publication date: February 10, 2011Applicant: DRACOPHARMA, INC.Inventor: Steven C. Quay
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Publication number: 20110033525Abstract: Several diterpene glycosides (e.g., rubusoside, rebaudioside, steviol monoside and stevioside) were discovered to enhance the solubility of a number of pharmaceutically and medicinally important compounds, including but not limited to, paclitaxel, camptothecin, curcumin, tanshinone HA, capsaicin, cyclosporine, erythromycin, nystatin, itraconazole, and celecoxib. The use of the diterpene glycoside rubusoside increased solubility in all tested compounds. The diterpene glycosides are a naturally occurring class of water solubility-enhancing compounds that are non-toxic and that will be useful as new complexing agents or excipients in the pharmaceutical, agricultural (e.g., solubilizing pesticides), cosmetic and food industries. Aqueous solutions by using rubusoside to increase the solubility of otherwise insoluble drugs will have several new routes of administration. In addition, aqueous solutions of therapeutic compounds with rubusoside were shown to retain the known pharmacological activity of the compounds.Type: ApplicationFiled: April 13, 2009Publication date: February 10, 2011Inventor: Zhijun Liu
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Patent number: 7883729Abstract: The invention concerns a natural vegetable oil selected among palm oil, corn germ oil, sunflower oil and canola oil, concentrated in unsaponifiable matters, such that said oil unsaponifiable matter content is 3 to 15% m/m. Said concentrated natural vegetable oil constitutes a novel food ingredient enriched in particular in vitamin E and phytosterol, useful as favored food source in vitamin E and phytosterol, meeting recommended daily intake.Type: GrantFiled: March 19, 2001Date of Patent: February 8, 2011Assignee: Laboratories ExpanscienceInventors: Carole Kohler, Philippe Msika, Antoine Piccirilli
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Publication number: 20110027200Abstract: Methods for stabilizing, maintaining the activity of and inhibiting growth of microorganisms in sunscreen preparations, anti-oxidant preparations and topical and oral pills and supplements by addition of at least one molecule chosen from nitroxides and nitrones and compositions produced thereby are provided.Type: ApplicationFiled: July 30, 2010Publication date: February 3, 2011Inventor: Eric F. Bernstein
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Publication number: 20110028542Abstract: A pharmaceutical composition for 1) increasing weight gain; and/or 2) decreasing weight loss; and/or 3) increasing appetite in a subject in need thereof, comprising purified ?-caryophyllene together with a pharmaceutically acceptable carrier. Also provided are pharmaceutical compositions for use in the prevention or treatment of Anorexia-Cachexia Syndrome, the pharmaceutical composition comprising purified ?-caryophyllene together with a pharmaceutically acceptable carrier.Type: ApplicationFiled: May 6, 2008Publication date: February 3, 2011Inventors: Jean Legault, Andre Pichette
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Publication number: 20110020228Abstract: A method for the treatment of cancer involves delivering a surface active agent to an organism, where the surface active agent selectively partitions to and kills cancer cells as opposed to healthy cells. The surface active agent can be an ionic or a non-ionic surfactant with a HLB of less than 29 or a mixture of surface active agents with a HLB of less than 40, where the hydrophobic portion is a lesser fraction of the surface active agent than the hydrophilic portion. A fluorescence method of detecting and locating cancer cells in an organism involves delivering a surface active agent, where the surface active agent includes a fluorescence moiety that upon selective partitioning of the surface active agent to the cancer cells and irradiation by a radiation source to excite the fluorescence moiety, a fluorescence emission is observed permitting the detection and location of the cancerous tissue by local volumes of relatively high intensity emission.Type: ApplicationFiled: February 2, 2009Publication date: January 27, 2011Applicant: University of Florida Resarch Foundation, Inc.Inventors: Brij M. Moudgil, Manoj Varshney, Stephen R. Grobmyer
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Publication number: 20110021622Abstract: This invention relates to a 10-component stabilized synthetic honey bee brood pheromone and methods of stabilizing said pheromone by adding one or more antioxidants, thereby enabling the production and sustained use of commercial products based on that pheromone. The 11-component stabilized pheromone composition formed by adding the antioxidant tertiary-butyl hydroquinone to a synthetic blend of ethyl linoleate, ethyl linolenate, ethyl oleate, ethyl palmitate, ethyl stearate, methyl linoleate, methyl linolenate, methyl oleate, methyl palmitate and methyl stearate can be used in generic or race-specific ratios to manipulate the behavior and improve the performance of worker honey bees, resulting in overall increased vigor of the hive.Type: ApplicationFiled: May 5, 2010Publication date: January 27, 2011Applicants: CONTECH ENTERPRISES INC., THE TEXAS A&M UNIVERSITY SYSTEMInventors: Tanya Pankiw, Bradley N. Metz, Norman Avelino, Jean Pierre Lafontaine
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Publication number: 20110021508Abstract: The present invention relates to compositions comprising a combination of PKC activators and PKC inhibitors and methods to modulate ?-secretase activity; improve or enhance cognitive ability; and or reduce neurodegeneration in individuals suffering from diseases that impair cognitive ability, particularly Alzheimer's Disease. The invention also relates to methods for improving or enhancing cognitive ability. The present invention also provides methods for increasing the generation of non-amyloidogenic soluble APP (sAPP) comprising the activation of protein kinase C (PKC) in the brain and inhibiting PKC in peripheral tissues. Macrocyclic lactones (i.e. bryostatin class and neristatin class) are preferred PKC activators and Vitamin E is a preferred PKC inhibitor for use in the inventive composition.Type: ApplicationFiled: September 16, 2010Publication date: January 27, 2011Applicant: BLANCHETTE ROCKEFELLER NEUROSCIENCES INSTITUTEInventor: Daniel Alkon
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Publication number: 20110014277Abstract: Disclosed is a compound and methods for use by an individual attempting to reduce or cease tobacco smoking or one exposed to environmental tobacco smoke. The compound includes a first component blocking nicotine receptor sites to reduce nicotine cravings or withdrawal symptoms, a second component increasing serotonin levels and acting synergistically with the first component to reduce nicotine cravings or withdrawal symptoms, assisting in maintaining body weight and reducing increased stress and anxiety, and a third component acting synergistically with the first and/or second component to reduce nicotine cravings or withdrawal symptoms, maintain body weight, and/or reduce increased stress and anxiety. The third component comprises a supplement that replenishes depleted body substance(s), repairs damaged body substance(s), and/or ameliorates the impaired function of body substance(s). Some combination of the first, second, and third component alters the perceived taste of tobacco smoke.Type: ApplicationFiled: September 29, 2010Publication date: January 20, 2011Inventor: Harlan Clayton Bieley
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Patent number: 7872042Abstract: The present invention provides methods for elevating IKBKAP gene expression and the level of functional IKAP protein in cells, which are beneficial to human individual, such as an individual suffering from Familial Dysautonomia, by providing one or more tocotrienols alone or in combination with one or more tocopherols to the cells. The present invention also provides methods for treating Familial Dysautonomia by providing tocotrienols alone or in combination with one or more tocopherols to a patient having Familial Dysautonomia. Related therapeutic kits are also provided.Type: GrantFiled: May 13, 2005Date of Patent: January 18, 2011Inventors: Berish Y. Rubin, Sylvia L. Anderson
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Patent number: 7868045Abstract: Provided is a method for promoting bicarbonate secretion in the stomach or duodenum in a mammalian subject, which comprises administering an effective amount of a compound of Formula (I): to a subject in need thereof, wherein A, Y, W1, W2, X1, X2 R1 and R2 are herein defined. The compound are also useful for protecting the gastrointestinal tract of a mammal from mucosal damage.Type: GrantFiled: September 5, 2007Date of Patent: January 11, 2011Assignee: Sucampo AGInventor: Ryuji Ueno
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Publication number: 20110002905Abstract: The present invention relates to compositions containing one or more proteins, one or more polysaccharides and one or more fat-soluble active ingredients and their use for the enrichment, fortification and/or coloration of food beverages, animal feed and/or cosmetics.Type: ApplicationFiled: February 23, 2010Publication date: January 6, 2011Applicants: DSM IP ASSETS B.V., FUDAN UNIVERSITYInventors: Chyi-Cheng CHEN, Ping Yao, Bruno H. Leuenberger, Gerhard Wagner, Keke Xu, Shi-Kchen Chen
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Patent number: 7863324Abstract: The present invention provides methods for inhibiting the growth of androgen-independent prostate cancer tumor cells in a human comprising administering to the human. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived compounds useful in the alleviation of cancer.Type: GrantFiled: May 29, 2008Date of Patent: January 4, 2011Assignee: Wisconsin Alumni Research FoundationInventors: Todd A. Thompson, George Wilding
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Publication number: 20100330146Abstract: An appliance for the delivery of at least one bioactive agent to the eye has at least one diffusion attenuator within a hydrophilic or silicone-hydrogel contact lens. The bioactive agent can be a drug or a nutraceutical. The diffusion attenuator can be a plurality of solid particles or phase separated liquid aggregates within at least one continuous phase of the lens where the diffusion attenuators promote a tortuous path for the diffusion of the bioactive agent to mediate the rate by which the bioactive agent diffuses from the contact lens. The diffusion attenuator can be homogeneously dispersed throughout at least one continuous phase of the lens to modify the diffusivity of the bioactive agent through that phase. The diffusion attenuator can have little or no affinity for the bioactive agent or can be miscible with the bioactive agent. The diffusion attenuator can be incorporated while forming the contact lens by polymerization of a monomer mixture containing the diffusion attenuator.Type: ApplicationFiled: July 22, 2010Publication date: December 30, 2010Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC.Inventors: ANUJ CHAUHAN, JINAH KIM
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Publication number: 20100330171Abstract: Nutritional supplements for eye health comprising: an anti-oxidant component; an anti-inflammatory component; and an anti-angiogenic component. The supplements inhibit development and progression of a range of retinal diseases and degenerations, particularly AMD and diabetic eye disease, diabetic retinopathy and diabetic macular edema. The supplements include tocotrienol and green tea extract.Type: ApplicationFiled: January 21, 2010Publication date: December 30, 2010Inventors: Jeffrey P. Gilbard, Johanna M. Seddon
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Publication number: 20100324132Abstract: The present invention provides methods and compositions that use the combination of Tris and EDTA to inhibit the growth of microorganisms at the site of a wound or burn, and/or to promote the healing of a wound or burn, and/or to reduce the sensation of pain at the site of a wound or burn. The amount of Tris and EDTA applied to a wound or burn can be selected to achieve one or more of the foregoing effects.Type: ApplicationFiled: June 29, 2006Publication date: December 23, 2010Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDTIONInventors: Richard E. Wooley, Branson W. Ritchie, Douglas T. Kemp, Anthony C. Capomacchia, Victoria V. Burnley
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Patent number: 7851477Abstract: The present invention relates to a method for the treatment of skin redness by topically applying a composition containing caffeine to the affected skin. The invention method finds particular use on persons having at least one of the following symptoms: rosacea, folliculitis or skin irritated by chemical or physical peelings.Type: GrantFiled: May 12, 2004Date of Patent: December 14, 2010Assignee: L'OrealInventors: Catherine Marion, Gabrielle Sore