Bicyclo Ring System Having The Hetero Ring As One Of The Cyclos (e.g., Methylenedioxyphenyl Group, Etc.) Patents (Class 514/464)
  • Patent number: 11839679
    Abstract: The present disclosure relates to ?-diketone compounds, such as those having the structures: The disclosure also relates to cosmetic or dermopharmaceutical compositions comprising the same, and methods for using the compounds or compositions for improving the aesthetic appearance of a subject's skin, for example, improving one or more of skin tone, radiance, clarity, tautness, skin firmness, plumpness, suppleness, softness, skin texture, skin texturization and moisturization, appearance of skin contours, appearance of hollow cheeks, appearance of sunken, baggy, or dark circles under eyes, skin luster, brightness, skin thickness, and skin elasticity and/or resiliency comprising application of the compounds or compositions disclosed.
    Type: Grant
    Filed: June 29, 2021
    Date of Patent: December 12, 2023
    Assignee: BioSplice Therapeutics, Inc.
    Inventors: John Hood, Sunil Kumar Kc, Osman Kibar, Charlene F. Barroga
  • Patent number: 11779015
    Abstract: Disclosed herein are novel pesticide compounds and compositions. In particular, pesticide compositions comprising one or more pesticide volatile organic compounds (VOCs) are disclosed, wherein the pesticide is for Drosophila spp. and the one or more pesticide VOCs have the molecular formula CaHbOc wherein: a is between 4 and 13; b is 6, 8, 10, 12, 14, 16, 18, 20, 22 or 24; c is 1 or 2. The VOCs are linear, branched or cyclic alkanes or alkenes, and comprise a single ketone, aldehyde, alcohol or ester functionality, and wherein any cyclic alkane or alkene is selected from the group consisting of cyclohexane, cyclopentane, cyclopentene and cyclopentadiene. Also disclosed are Drosophila spp. pesticide compositions comprising one or more pesticide VOCs with the molecular formula of (formula I) wherein R1 is OH or absent, and R2 is an aldehyde functional group or a linear or branched alkane or alkene with 1 to 5 carbons and a single ester functional group.
    Type: Grant
    Filed: November 22, 2018
    Date of Patent: October 10, 2023
    Inventors: Elie Marina-Lora Fink, Matthieu Robert Paul Julien Cecile Guy Louis
  • Patent number: 11602520
    Abstract: The invention discloses a c-Met regulatory composition and its method for treating liver disease, a main component of the c-Met regulatory composition comprises Antrodin A and/or DMB (4,7-Dimethoxy-5-methyl-1,3-benzodioxole) capable of effectively regulating gene expression related to cell regeneration and cytothesis in hepatic cells, such as c-Met, Notch, etc., to achieve efficacies of repairing damaged hepatic cells and promoting hepatocyte regeneration.
    Type: Grant
    Filed: October 14, 2021
    Date of Patent: March 14, 2023
    Inventors: Pang-Kuei Hsu, Chun-Yi Ho, Chia-Feng Wu
  • Patent number: 11202795
    Abstract: This application relates to the field of neurodegenerative diseases, more particularly to the field of Parkinson's disease. In particular, the disclosure describes that inhibitors reducing FAS activity can be used for treatment of Parkinson's disease, in particular, the treatment of patients suffering from Parkinson's disease having loss of function mutations in PINK1 or PARKIN genes.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: December 21, 2021
    Assignees: VIB VZW, Katholieke Universiteit Leuven, KU Leuven R&E
    Inventors: Patrik Verstreken, Vanessa Morais Epifânio, Melissa Vos
  • Patent number: 11021413
    Abstract: The present invention relates to the use of compounds of formula (I) for reducing nitrification and to compositions comprising the compounds of formula (I) and to agricultural mixtures comprising at least one compound of formula (I) and at least one fertilizer. Furthermore, the present invention relates to a method for reducing nitrification comprising treating a plant growing on soil or soil substituents and/or the locus or soil or soil substituents where the plant is growing or is intended to grow with a compound of formula (I) or a composition comprising a compound of formula (I).
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: June 1, 2021
    Assignee: BASF SE
    Inventors: Barbara Navé, Joachim Dickhaut, Mihiret Tekeste Sisay, Alexander Wissemeier, Wolfram Zerulla, Gregor Pasda, Wolfgang Weigelt
  • Patent number: 10772857
    Abstract: Highly concentrated solutions are disclosed along with methods of inhibiting and/or ameliorating functional neurological disorders of the brain. The method may include administering directly to a brain of a subject a medicament multiple times over a time period of at least two days. The medicament may include a half-life of less than 2 hour in the cerebrospinal fluid. The method may include inhibiting and/or ameliorating a functional neurological disorder of the brain using the medicant.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: September 15, 2020
    Assignee: Cerebral Therapeutics, Inc.
    Inventors: Daniel J. Abrams, Thomas Joseph Anchordoguy
  • Patent number: 10449181
    Abstract: It is provided herein a method of treating an Autism Spectrum Disorder (ASD) in a patient by administering to the patient a therapeutically effective amount of a composition of a compound that is a positive allosteric modulator of the GABAA receptor having a selectivity towards an ?1 subunit of the receptor.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: October 22, 2019
    Inventor: Sarah E. Labance
  • Patent number: 10183008
    Abstract: Methods for terminating, preventing, and/or treating status epilepticus are generally provided. The method can include administering a prophylactically or therapeutically effective amount of stiripentol or a related compound thereof to an individual in need of treatment of status epilepticus. The individual can be in need of treatment of prolonged status epilepticus, refractory status epilepticus, and/or benzodiazepine-resistant status epilepticus.
    Type: Grant
    Filed: September 19, 2012
    Date of Patent: January 22, 2019
    Assignee: University of South Carolina
    Inventors: David D. Mott, Janet L. Fisher, Rene H. Levy, Marie-Emmanuelle LeGuern, Marc Verleye, Bernard Hublot
  • Patent number: 10159740
    Abstract: The present invention improves the solubility of sesamin-class compounds in fish oil and/or wheat germ oil. More specifically, ?-orizanol is combined with fish oil and/or wheat germ oil as well as sesamin-class compounds.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: December 25, 2018
    Inventors: Shuji Endo, Mitsuru Maeda
  • Patent number: 9957225
    Abstract: The invention provides methods of treating Friedreich's ataxia and other neurodegenerative or neuromuscular conditions using histone deacetylase inhibitors.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: May 1, 2018
    Assignee: The Scripps Research Institute
    Inventors: Joel M. Gottesfeld, Ann-Kristin Jenssen, David M. Herman, Ryan Burnett, C. James Chou
  • Patent number: 9833434
    Abstract: The present invention includes compositions and methods for the treatment of skin conditions by administration of a cyclolignan such as picropodophyllin and/or a derivative, metabolite, analog, prodrug, pharmaceutically acceptable salt, or hydrate thereof.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: December 5, 2017
    Assignee: m. Alphabet 2, L.L.C.
    Inventors: Howard Fein, Joshua M. Berlin
  • Patent number: 9497971
    Abstract: Water-based formulations (EW) are provided containing no VOC's or alternatively are low in VOC's for wide area space spray to control mosquitoes, flies, and other public health pests. Application via ULV, these formulations have been observed to provide significantly superior control of pests when compared to competitive adulticides. The present formulations provide exceptional preservation of both droplet density in the spray cloud and droplet size as measured by volume mean diameter (VmD). The present formulations provide superior bio-efficacy as measured by both mortality and knockdown of target organisms. The present formulations provide superior biological control, droplet density, and droplet size when applied at concentrations 20-80× less than competitive formulations.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: November 22, 2016
    Assignee: Bayer CropScience LP
    Inventors: Robert Britt Baker, Kurt P. Vandock, Gary Gore, Byron Reid
  • Patent number: 9339454
    Abstract: The invention provides a method for inhibiting dopa oxidase activity, for inhibiting melanin production, or for whitening skin using haguro-so or an organic solvent extract thereof, or a compound of formula (I):
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: May 17, 2016
    Assignee: Kao Corporation
    Inventors: Mamiko Kikuchi, Daiki Murase, Mitsuru Sugiyama, Akiko Kawasaki
  • Patent number: 9295684
    Abstract: The present invention relates to a cream composition of glucosamine, including at least 10 wt %-15 wt % of glucosamine HCL, a methylsulfonylmethane component, a chondroitin component, and a cream base, wherein the composition promotes penetration of glucosamine from skin of affected area by synergistic interaction between components, in order to enhance absorption of human body.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: March 29, 2016
    Inventor: Ming-Chen Lee
  • Patent number: 9161532
    Abstract: The invention is directed to emulsifiable oil suspension concentrate formulations containing cinnamaldehyde (cinnamic aldehyde) and allicin that are effective in protecting plants from pests, especially nematodes, and methods of their use.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: October 20, 2015
    Assignee: Valent BioSciences Corporation
    Inventors: Bala N. Devisetty, Bassam Shammo, Linda A. Rehberger, Rebecca Dickenson, Heemanshubhai K. Patel, Daniel F. Heiman
  • Patent number: 9012496
    Abstract: A pharmaceutical composition comprising Compound 1, (R)-1-(2,2-difluorobenzo[d][1,3]dioxo-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide, and at least one excipient selected from: a filler, a disintegrant, a surfactant, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering the pharmaceutical composition of Compound 1 are also disclosed.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: April 21, 2015
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Rossitza Gueorguieva Alargova, Craig Antony Dunbar, Irina Nikolaevna Kadiyala
  • Patent number: 9011925
    Abstract: A method for preparing polysaccharide nanocomposite particles is provided. The method comprises providing a first solution comprising an active component and a polysaccharide; adding a cross-linking agent to the first solution to provide a second solution; and allowing the second solution to conduct the reaction to form polysaccharide nanocomposite particles. The polysaccharide nanocomposite particles thus prepared show good coating ratio and enhanced applicability. Also provided is a method for inducing cancer cell apoptosis in a subject, comprising administrating to the subject an effective amount of the polysaccharide nanocomposite particles.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: April 21, 2015
    Assignee: China Medical University
    Inventors: Chih-Wei Chou, Yueh-Hsiung Kuo, Chin-Heng Yang
  • Publication number: 20150094285
    Abstract: A composition (e.g., phytochemical composition) including sesamin, the composition exhibiting anti-inflammatory, anti-cytokine storm, connective tissue preservation, anti-viral, and/or other properties in biological tissue. The phytochemical composition therapeutically affects a pro-inflammatory cytokine condition, for instance facilitating or effectuating decrease in a quantity of a pro-inflammatory cytokine, for example, interleukin-1 and tumor necrosis-alpha. The phytochemical composition facilitates or effectuates an increase in quantity of an anti-inflammatory cytokines. The phytochemical composition can additionally facilitate a connective tissue extracellular matrix (ECM) preservation effect. The phytochemical composition can also inhibit an action of a viral neuraminidase, for example, the influenza A virus neuraminidase.
    Type: Application
    Filed: December 5, 2014
    Publication date: April 2, 2015
    Inventor: Prachya KONGTAWELERT
  • Publication number: 20150093427
    Abstract: An insecticidal polymer matrix containing Piperonyl Butoxide (PBO) and deltamethrin (DM), wherein the ratio between the content of PBO and the content of DM in terms of weight is higher than 3.
    Type: Application
    Filed: December 8, 2014
    Publication date: April 2, 2015
    Inventors: Mikkel Vestergaard Frandsen, Michael Stanley Pedersen, Matthieu Zellweger, Sebastien Gouin, Sicco Dirk Roorda, Thi Quynh Chi Phan
  • Patent number: 8987325
    Abstract: The invention relates to a novel class of inhibitors of arachidonic acid formation that can be useful for treating inflammatory conditions. Specifically, the invention relates to derivatives of sesamol that confer lower toxicity and increased circulatory lifetimes than pure sesamol.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: March 24, 2015
    Inventor: Barry D. Sears
  • Patent number: 8969408
    Abstract: The present invention relates to a new use of lignan-type compounds or an extract of nutmeg or aril of nutmeg comprising the same. More particularly, the present invention relates to a composition for skin whitening comprising a lignan-type compound or an extract of nutmeg or aril of nutmeg comprising the same. Because the lignan compound represented by Chemical Formulas 1 to 3 or the extract of nutmeg or aril of nutmeg has superior skin whitening activity by inhibiting melanin production and tyrosinase activity, it can be used for the preparation of a cosmetic composition, food composition or pharmaceutical composition for skin whitening.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: March 3, 2015
    Assignees: Biocare Co., Ltd., Newtree Co., Ltd.
    Inventors: Jae Kwan Hwang, Yu-Mi Cho, Gyu Hoi Kim, Jeong Hwan Kim, Hae Ji Lee, Do Un Kim, Hee Chul Chung, Jae Youn Chung, Hyun In Oh
  • Publication number: 20150051247
    Abstract: Compounds and methods for treating or preventing cancer associated with binding to the urokinase receptor are provided. Biological processes affected by the compounds include cell migration, cell growth, cell adhesion, angiogenesis, cancer cell invasion, apoptosis, tumor formation, tumor progression, metastasis, degradation of the extracellular matrix, pericellular proteolysis, activation of plasminogen, changes in the levels of an extracellular protease, and changes in the levels of a VEGF receptor.
    Type: Application
    Filed: August 16, 2012
    Publication date: February 19, 2015
    Inventor: Samy O. Meroueh
  • Publication number: 20150044293
    Abstract: Radioprotector compounds including 3,3?-diindolylmethane (DIM) analogs, are provided. Further provided are methods for their use in reducing or preventing radiation damage, killing a tumor cell and protecting a non-tumor cell, and treating cancer.
    Type: Application
    Filed: March 14, 2013
    Publication date: February 12, 2015
    Applicant: Georgetown University
    Inventors: Eliot M. Rosen, Milton Brown, Saijun Fan, Thomas Walls, Kathryn E. Ditmer
  • Publication number: 20150038574
    Abstract: Compounds and compositions are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
    Type: Application
    Filed: November 29, 2012
    Publication date: February 5, 2015
    Applicant: Bikam Pharmaceuticals, Inc.
    Inventors: David S. Garvey, Judd Berman, Tan Quach
  • Patent number: 8927600
    Abstract: The present invention relates to a compound of the following formula (I): or a pharmaceutically acceptable salt thereof, for use in the prevention or treatment of peripheral neuropathies.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: January 6, 2015
    Assignee: Biocodex
    Inventors: Marie-Emmanuelle Le Guern, Marc Verleye, Jean-Marie Gillardin, Bernard Hublot
  • Patent number: 8921414
    Abstract: The present invention relates to spiroketal compounds that are useful in methods of treating or preventing protozoal infections, parasitic infections, bacterial infections, cell proliferative disorders and anti inflammatory disorders. The spiroketal compounds are also useful as immunosuppressive agents, and also in methods of controlling pests.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: December 30, 2014
    Assignee: EcoBiotics Ltd
    Inventors: Paul Warren Reddell, Victoria Anne Gordon
  • Publication number: 20140371271
    Abstract: The present invention provides novel piperine derivatives. The present pharmaceutical or food composition containing a piperine derivative as an active ingredient is very effective in preventing or treating metabolic diseases including obesity, diabetes, dyslipidemia, fatty liver and insulin resistance syndrome. Piperine derivatives of the present invention useful as pharmaceuticals compositions or functional food compositions has therapeutic efficacies for metabolic syndrome selected from the group consisting of obesity, diabetes, hyperlipidemia, fatty liver and insulin resistance syndrome, and also suppress the differentiation of progenitor cells and reduce the accumulation of triglycerides.
    Type: Application
    Filed: December 27, 2012
    Publication date: December 18, 2014
    Applicant: Industry-Academic Cooperation Foundation, Yonsei University
    Inventors: Tae Sun Park, Nak Shin Jeong
  • Patent number: 8906400
    Abstract: An insecticidal polymer matrix containing Piperonyl Butoxide (PBO) and deltamethrin (DM), wherein the ratio between the content of PBO and the content of DM in terms of weight is higher than 3.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: December 9, 2014
    Assignee: Vestergaard Frandsen SA
    Inventors: Mikkel Vestergaard Frandsen, Michael Stanley Pedersen, Matthieu Zellweger, Sebastien Gouin, Sicco Dirk Roorda, Thi Quynh Chi Phan
  • Patent number: 8906955
    Abstract: A method for treating an aging-related disease is disclosed comprising administering to a subject a pharmaceutical composition comprising an adrenergic beta-3-receptor agonist.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: December 9, 2014
    Inventors: Shuguang Lin, Meng Zheng
  • Patent number: 8901167
    Abstract: Disclosed are compositions and methods for the inhibition of biofilm formation or reduction of existing or developing biofilms in a patient. These methods also inhibit the aggregation of bacteria that form biofilms in the airways. The methods include administering to a subject that has or is at risk of developing biofilms a compound or formulation that inhibits the formation or polymerization of actin microfilaments or depolymerizes actin microfilaments at or proximal to the site of biofilm formation. Such a compound can be administered in combination with a compound or formulation that inhibits the accumulation or activity of cells that are likely to undergo necrosis at or proximal to the site of biofilm formation (i.e., neutrophils). The methods and compositions can further include the use of anti-DNA and/or anti-mucin compounds, as well as other therapeutic compounds and compositions.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: December 2, 2014
    Assignee: National Jewish Health
    Inventors: Jerry A. Nick, Travis S. Walker, G. Scott Worthen
  • Patent number: 8889721
    Abstract: The invention relates to a mixture comprising clothianidin, metofluthrin, and piperonyl butoxide which provides superior insect knockdown and mortality rates, and is especially effective against bed bugs. This mixture of actives may be formulated with adjuvants, such as solvents, anti-caking agents, stabilizers, defoamers, slip agents, humectants, dispersants, wetting agents, thickening agents, emulsifiers, and/or preservatives which increase the activity of the mixture. Mixtures of the present invention have long lasting residual control.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: November 18, 2014
    Assignee: McLaughlin Gormley King Company
    Inventors: David Jeffries, Deanna Branscome
  • Patent number: 8883849
    Abstract: The present invention provides a new composition for treating pain-associated sleep disturbances, especially shortened sleep duration, comprising ibuprofen and diphenhydramine. The composition is further prepared as a bilayer tablet or caplet, or alternatively as a soft gelatin capsule composition, to prevent interaction between the active ingredients.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: November 11, 2014
    Assignee: Wyeth LLC
    Inventors: Graham D. Cook, Todd S. Koch, David H. Giamalva, Justin Bianco, James J. Fort, Geraldine Doyle, Steven Cooper
  • Patent number: 8877802
    Abstract: A method of treating a subject for Parkinson's disease comprises administering said subject a phenylisopropylamine in an amount effective to treat said Parkinson's disease. In some embodiments the method is used to treat at least a motor symptom of Parkinson's disease; in some embodiments the method is used to treat at least a non-motor symptom of Parkinson's disease.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: November 4, 2014
    Assignee: Duke Univerity
    Inventors: Marc G. Caron, Tatyana D. Sotnikova, Raul R. Gainetdinov
  • Publication number: 20140323520
    Abstract: The present disclosure provides methods of increasing proliferation of adult salivary stem cells. The methods include contacting adult salivary stem cells in vivo, in vitro, or ex vivo with an aldehyde dehydrogenase (ALDH) agonist. Increasing proliferation of adult salivary stem cells can be carried out to provide for an increase in the number of adult salivary stem cells in an indi vidual undergoing radiotherapy for head and neck cancer.
    Type: Application
    Filed: April 26, 2012
    Publication date: October 30, 2014
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Che-Hong Chen, Daria Mochly-Rosen, Quynh-Thu Le
  • Patent number: 8858991
    Abstract: Disclosed herein are controlled-release oral pharmaceutical dosage forms comprising MGBG, and their application for the improved treatment of diseases with reduced side effects and/or longer time at maximum concentration.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: October 14, 2014
    Assignee: Pathologica LLC
    Inventors: John McKearn, Jeremy Blitzer
  • Patent number: 8853264
    Abstract: The present invention relates to the use of lignan compounds for treating or preventing an inflammatory disease. More particularly, it relates to a method for preventing or treating an inflammatory disease, comprising administering to a subject in need thereof an effective amount of macelignan represented by Chemical Formula I or a pharmaceutically acceptable salt thereof. The lignan compound has the effect of inhibiting inflammatory reactions by inhibiting the production or expression of inflammation mediators NO, iNOS, PGE2, COX-2 and TNF-? and by treating or preventing inflammatory disease in vivo. Accordingly, the lignan compound or a Myristica fragrans extract will be highly useful for the treatment or prevention of an inflammatory disease.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: October 7, 2014
    Assignees: Newtree Industry Co., Ltd.
    Inventors: Jae-Kwan Hwang, Do-Un Kim, Jae-Youn Chung, Hee-Chul Chung, Kyu-Lee Han
  • Patent number: 8846753
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: September 30, 2014
    Assignee: Vertex Pharamaceuticals Incorporated
    Inventors: Sara S Hadida Ruah, Mark T. Miller, Brian Bear, Jason McCartney, Peter D. J. Grootenhuis
  • Publication number: 20140275172
    Abstract: The present invention is directed to benzo-fused heterocyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by GPR120. More particularly, the compounds of the present invention are agonists of GPR120, useful in the treatment of, such as for example, Type II diabetes mellitus.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 18, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: Zhihua Sui, Nalin Subasinghe
  • Publication number: 20140249192
    Abstract: The present invention provides compounds, that are N-alkyl-2-(1-(5-substituted-2-(3-oxo-3-(trifluoromethylsulfonamido)propyl)benzyl)pyrrolidin-2-yl)oxazole-4-carboxamide wherein the 5 substituent is selected from the group consisting of halo and alkyloxy radicals. The compound may be represented by the following formula wherein R1 is selected from the group consisting of CO2R7 and CON(R7)SO2R7 wherein R1, R2, R3, R4, and R7 are as defined in the specification. The compounds may be administered to treat DP1, FP, EP1, EP3, TP and/or EP4 receptor mediated diseases or conditions.
    Type: Application
    Filed: February 12, 2014
    Publication date: September 4, 2014
    Applicant: Allergan, Inc.
    Inventors: Jose L. Martos, William R. Carling, David F. Woodward, Jenny W. Wang, Jussi J. Kangasmetsa
  • Publication number: 20140249199
    Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula (I), pharmaceutical compositions having a compound of formula (I), and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula (I) to a subject in need thereof.
    Type: Application
    Filed: July 19, 2012
    Publication date: September 4, 2014
    Inventors: Huw M. L. Davies, Spandan Chennamadhavuni, Andrei Bakin
  • Publication number: 20140243349
    Abstract: The present disclosure provides ?-diketones or analogs thereof, that activate Wnt/?-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.
    Type: Application
    Filed: February 21, 2014
    Publication date: August 28, 2014
    Inventors: Sunil Kumar KC, David Mark Wallace, John Hood, Charlene F. Barroga
  • Patent number: 8809389
    Abstract: A composition comprising an alkynyl phenoxy compound of Formula (I) as a synergist and a pesticidal active ingredient is described, wherein R1 and R2, similar or different, are (C1-C4)alkyl or R1O— and R2O— together represent a group —O—CH2—O—, —O—CH(CH3)—O, —O—CH2—CH2—O—, —O—CH2—CH2—, R3 is (C1-C6)alkyl, (C3-C6)alkenyl or —B—(CH2—CH2—O)z-R6 where B is —CH2—O— or —O—, z is 0, 1 or 2 and R6 is (C1-C4)alkyl; R4 is hydrogen or methyl; R5 is hydrogen or methyl; x is an integer from 1 to 2; y is 0, 1 or 2; with the proviso that when R3 is —B—(CH2CH2—O)z-R6, y is 1 and 5-(propargyloxy)-benzo[1,3]dioxole is excluded.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: August 19, 2014
    Assignees: Endura S.p.A., Rothamsted Research Ltd.
    Inventors: Valerio Borzatta, Elisa Capparella, Leni Moroni, Graham Moores, Despina Philippou
  • Publication number: 20140221468
    Abstract: Store operated calcium channel modulating compounds, and methods for using the same, are provided. These compounds and methods find use in a variety of applications in which modulation of store operated calcium channels is desired.
    Type: Application
    Filed: December 9, 2011
    Publication date: August 7, 2014
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chan Young Park, Amir M. Sadaghiani, Ricardo Ei Dolmetsch
  • Patent number: 8791156
    Abstract: A polyacetylenes and application thereof. The polyacetylenes is isolated from an extract of the sporophores of Antrodia Cinnamomea and has a function of inhibiting the production of nitric oxide. Therefore, the polyacetylenes can be used for preparing a pharmaceutical composition for anti-inflammation. The present invention also teaches the representative metabolites of the sporophores of Antrodia Cinnamomea, which can be used to evaluate the quality thereof.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: July 29, 2014
    Inventors: Sheng-Yang Wang, Ting-Yu Lin, Chieh-Yin Chen, Shih-Chang Chien, Wen-Wei Hsiao, Fang-Hua Chu, Wen-Hsiung Li, Jei-Fu Shaw, Chin-Chung Lin
  • Publication number: 20140194506
    Abstract: The invention provides the use of potassium piperonyl pentadienoate for lowering blood lipid, including the use of the potassium piperonyl pentadienoate in the preparation of medicaments and health-care products for lowering serum total cholesterol, lowering low density lipoprotein cholesterol, lowering triglyceride as well as preventing the decrease of high density lipoprotein cholesterol.
    Type: Application
    Filed: August 13, 2012
    Publication date: July 10, 2014
    Inventors: Gereltu Borjihan, Narisu Bao, Zhaorigetu Sun, Mingfang Wang
  • Patent number: 8771740
    Abstract: Nanoparticles of a compound are produced by spraying a solution of the compound into a heated chamber. The resulting product comprises a free flowing mixture of nanoparticles of the compound.
    Type: Grant
    Filed: May 21, 2006
    Date of Patent: July 8, 2014
    Inventor: Nicholas J. Kerkhof
  • Publication number: 20140179626
    Abstract: Acadesine derivatives as a drug, as well as the derivatives for the treatment of cancer and in particular for the treatment of chronic myeloid leukemia are described. Also, product containing the derivatives and at least one second active ingredient as a combination product for simultaneous, separate or sequential administration, in the treatment of cancer, as well as a pharmaceutical composition containing the derivatives and a pharmaceutically acceptable carrier are described. Finally, a method for inhibiting the in vitro cell proliferation including the placement of an in vitro cell in contact with the derivatives and methods for synthesis of said derivatives and methods for synthesis of the derivatives are described.
    Type: Application
    Filed: April 17, 2012
    Publication date: June 26, 2014
    Inventors: Rachid Benhida, Patrick Auberger, Vincent Malnuit, Mohsine Driowya, Alexandre Puissant, Guillaume Robert
  • Patent number: 8759549
    Abstract: This invention relates to a novel compound extracted from antrodia Cinnamomea and related compounds of formula (1), and pharmaceutical compositions comprising the compound of formula (1) and a pharmaceutically acceptable carrier or excipient. The invention further comprises the method of inhibit cancer cells by administering an effective amount of the compound of formula (1).
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: June 24, 2014
    Inventors: Ching-Kuo Lee, Pi-Yu Chen, Jir-Mehng Lo, Wen-Bin Zhong, Tien-Wang Chiu, Chieh-Chou Yu
  • Publication number: 20140161763
    Abstract: The methods, kits, and products for controlling a target insect population are disclosed in which a non-host plant containing a toxin and a chemical attractant known to attract the target insect is treated with chemical attractant from a plant of interest. The chemical attractant induces the target insect to lay eggs on the non-host plant. The resulting offspring die of starvation from refusing to feed on the non-host plant. The non-host plant and plant of interest contain at least one common chemical. The methods, kits, and products for controlling a target insect population using an extract from a non-host plant are also disclosed. The non-host plant extract is applied to the plant of interest, and when ingested or applied directly to the target insect, kills the target insect or causes it to develop with deformities.
    Type: Application
    Filed: January 28, 2011
    Publication date: June 12, 2014
    Applicant: University of the West Indies, a Regional Institution, established by Royal Charter
    Inventors: Trevor Herbert Yee, Charah Tabetha Watson, Eric Garraway, Dwight Robinson, Nemoi Nastassia Sri Garcia Chisholm
  • Publication number: 20140161856
    Abstract: By incorporating PBO and phtalocyanine in a polymeric matrix, the surface concentration of the PBO after migration to the surface is reduced relatively to a matrix without phtalocyanine. This can be used to control the migration of PBO and retain PBO for a long-lasting effect.
    Type: Application
    Filed: May 2, 2011
    Publication date: June 12, 2014
    Inventors: Mikkei Vestergaard Frandsen, Sebastien Gouin, Matthieu Zellweger, Huyen Thanh Hoang