Bicyclo Ring System Having The Hetero Ring As One Of The Cyclos (e.g., Methylenedioxyphenyl Group, Etc.) Patents (Class 514/464)
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Patent number: 8734869Abstract: Pest control compositions, blends, and formulations are disclosed. The blends contain, in a synergistic combinations, at least two ingredients such as Lilac Flower Oil, D-Limonene, Thyme Oil, Lime Oil, Black Seed Oil, Wintergreen Oil, Linalool, Tetrahydrolinalool, Vanillin, Isopropyl myristate, Piperonal (aldehyde), Geraniol, Geraniol 60, Triethyl Citrate, and Methyl Salicylate.Type: GrantFiled: March 21, 2008Date of Patent: May 27, 2014Assignee: TyraTech, Inc.Inventor: Essam Enan
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Publication number: 20140107162Abstract: Provided are compositions comprising (i) a neonicotinoid; and (ii) a compound of formula (I) or (II), preferably wherein the composition is a pesticide composition, for example an insecticide composition. Also provided is use of a compound of formula (I) or (II) as a neonicotinoid synergist and use of a compound of formula (I) or (II) in combination with a neonicotinoid. Further provided are methods for controlling pests.Type: ApplicationFiled: March 7, 2012Publication date: April 17, 2014Applicants: ENDURA S.P.A., ROTHAMSTED RESEARCH LIMITEDInventors: Graham David Moores, Despina Philippou, Valerio Borzatta, Elisa Capparella
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Publication number: 20140099385Abstract: An object of the present invention is to provide a composition for inhibiting fatty acid and cholesterol uptake in a living cell which is an inhibitor for fatty acid or cholesterol uptake by a living cell, comprising carbon monoxide (CO) or a compound capable of releasing CO in vivo.Type: ApplicationFiled: June 6, 2012Publication date: April 10, 2014Inventors: Makoto Suematsu, Yasuaki Kabe
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Patent number: 8686042Abstract: The invention relates to urea derivatives of formula (I) as inhibitors of glycogen synthase kinase 3?, GSK-3, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which GSK-3 is involved, such as Alzheimer's disease or non-insulin dependent diabetes mellitus.Type: GrantFiled: July 28, 2006Date of Patent: April 1, 2014Assignee: Neuropharma, S.A.Inventors: Ana Martinez Gil, Miguel Medina Padilla, Mercedes Alonso Cascon, Ana Fuertes Huerta, Maria Luisa Navarro Rico, Maria Jose Perez Puerto, Ana Castro Morera, Ester Martin Aparicio
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Publication number: 20140088186Abstract: A composition for preventing and/or treating dementia and ameliorating memory impairment and/or improving memory, comprising one or more arylnaphthalene lignan derivatives, such as Justicidin A, 5-methoxyjusticidin A, Chinensinaphthol, and a pharmaceutically-acceptable salt thereof, as active ingredient.Type: ApplicationFiled: September 25, 2013Publication date: March 27, 2014Applicants: The Council for Scientific and Industrial Research, KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Hyun Ok Yang, Sung-Kwon Chung, Hak Cheol Kwon, Jin Wook Cha, Young-Joo Kim, Gerda Fouche, Rudzani Nthambeleni, Dashnie Naidoo, Jeremiah Senabe, Vinesh Jaichand Maharaj, Eric Khorombi, Jungyeob Ham, Joon Ki Kim
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Patent number: 8680141Abstract: The present invention relates to spiroketal compounds that are useful in methods of treating or preventing protozoal infections, parasitic infections, bacterial infections, cell proliferative disorders and anti inflammatory disorders. The spiroketal compounds are also useful as immunosuppressive agents, and also in methods of controlling pests.Type: GrantFiled: May 17, 2013Date of Patent: March 25, 2014Assignee: EcoBiotics LtdInventors: Paul Warren Reddell, Victoria Anne Gordon
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TRITERPENOID DERIVATIVES, BENZENOID DERIVATIVES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
Publication number: 20140066498Abstract: The present invention relates to triterpenoid derivatives, benzenoid derivatives, and pharmaceutical compositions containing the same for treating cancers or inflammatory symptoms. According to the present invention, the triterpenoid derivatives and the benzenoid derivatives are respectively represented by the following formulas (I) and (II): wherein, R1, R2, R3, R4, R5, R6, R7, R8, , , , R1?, R2?, R3?, and R4? are defined the same as the specification.Type: ApplicationFiled: November 8, 2013Publication date: March 6, 2014Applicant: National Cheng Kung UniversityInventor: TIAN-SHUNG WU -
Publication number: 20140056988Abstract: The invention relates to a novel class of inhibitors of arachidonic acid formation that can be useful for treating inflammatory conditions. Specifically, the invention relates to derivatives of sesamol that confer lower toxicity and increased circulatory lifetimes than pure sesamol.Type: ApplicationFiled: May 14, 2013Publication date: February 27, 2014Inventor: Barry D. Sears
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Patent number: 8658838Abstract: The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.Type: GrantFiled: December 20, 2012Date of Patent: February 25, 2014Assignee: Unigen, Inc.Inventors: Sandip K. Nandy, Jiyun Liu, Alexandre Mikhailovitch Nesterov, Carmen Hertel, Abeysinghe A. Padmapriya
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Patent number: 8653130Abstract: A method by which the physiological activities of sesamin-class compounds can be efficiently exhibited and enhanced, as well as an effective compound that can be combined with the sesamin-class compounds to this end. By using sesamin-class compounds in combination with more than specified proportions of arachidonic acid class compounds, the physiological activities of the sesamin-class compounds, for example, their anti-fatigue action is synergistically enhanced to provide compositions that are safe in humans and non-human animals and which hence can be ingested continuously.Type: GrantFiled: September 17, 2008Date of Patent: February 18, 2014Assignee: Suntory Holdings LimitedInventors: Daisuke Takemoto, Masanori Kontani, Yoshiko Ono, Yoko Yasutake
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Publication number: 20140037563Abstract: Provided are compositions comprising Paulownin or an extract of Paulownia tomentosa wood and methods of use thereof.Type: ApplicationFiled: October 17, 2013Publication date: February 6, 2014Inventors: Simarna Kaur, Khalid Mahmood, Claude Saliou, Michael D. Southall
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Patent number: 8642646Abstract: The present invention relates to a method and composition for treating acne using lignan compounds represented by Formula 1. More particularly, the invention relates to an antibacterial composition against acne-causing bacteria, containing lignan compounds represented by Formula 1, as well as a method for treating acne using the same. The lignan compounds represented by Formula 1 are excellent not only in the antibacterial activity of inhibiting the growth of acne-causing bacteria, but also in thermal stability. Accordingly, the lignan compounds may be useful as antibacterial agents against the acne-causing bacteria, and acne treatment agents.Type: GrantFiled: January 7, 2005Date of Patent: February 4, 2014Assignees: New Tree Industry Co., Ltd.Inventors: Jae-Kwan Hwang, Jae-Youn Chung, Hee-Chul Chung, Kyung-Min Park
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Patent number: 8633242Abstract: The present invention relates to benzylidene indanones of general formula 1. The compounds exhibited tubulin polymerisation inhibition. A series of compounds 2-benzylidene 3-(3,4,5-trimethoxyphenyl) indanones having general formula 1 were synthesized from gallic acid through a chemical process. 2-(3,4-Methylenedioxybenzylidine), 3-(3,4,5-trimethoxyphenyl), 4,5,6-trimethoxyindanone (8), a representative compound of this series possessing the molecular formula C29H28O9, was synthesized from gallic acid and exhibits potent anticancer activity. Compound 8 was evaluated for acute oral activity in Swiss albino mice and found to be safe up to 300 mg/kg body weight. The anticancer activity of the compounds has been determined, in order to obtain new potent and cost effective molecules using an in vitro cytotoxicity assay.Type: GrantFiled: September 20, 2012Date of Patent: January 21, 2014Assignee: Council of Scientific and Industrial ResearchInventors: Arvind Singh Negi, Ayyampudur Palanisamy Prakasham, Ajit Kumar Saxena, Suaib Luqman, Debabrata Chanda, Tandeep Kaur, Atul Gupta
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Publication number: 20130303605Abstract: Disclosed herein are an external composition for skin, which contains, as an active ingredient, manassantin B extracted from Saururus chinensis Baill, and the use thereof for skin whitening. More particularly, disclosed are an external composition for skin, which contains, as an active ingredient, manassantin B, which inhibits the transfer of melanosomes, thus providing a skin-whitening effect without influencing the melanin synthesis function of the melanocytes, as well as the use thereof for skin whitening.Type: ApplicationFiled: July 11, 2013Publication date: November 14, 2013Inventors: Hui Kyoung CHANG, Dae Gun KIM, Myeong Hoon YEOM, Hyun Jung CHOI, Kyung Mi JOO, Jae Sung HWANG, Soo Mi AHN
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Publication number: 20130303437Abstract: The disclosure provides a molecular genetic approach of targeted mutagenesis and heterologous expression, coupled with in vitro and in vivo models of bacterial pathogenesis, to demonstrate that the S. aureus pigment is a virulence factor and potential novel target for antimicrobial therapy.Type: ApplicationFiled: July 16, 2013Publication date: November 14, 2013Inventors: Victor NIZET, George Y. LIU
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Publication number: 20130287831Abstract: A method for preventing or reducing resistance to a pesticide of a substrate pest, which method comprises the administration to the substrate or the pest of a composition comprising: (a) a rapid-release formulation of an inhibitor of a factor causing or contributing to the resistance of the pest to the pesticide; and, substantially simultaneously, (b) a non-rapid release formulation of the pesticide. The invention also provides compositions suitable for use in such a method.Type: ApplicationFiled: June 25, 2013Publication date: October 31, 2013Applicants: Department of Primary Industries for and on behalf of the State of New South Wales, Rothamsted Research LimitedInventors: Graham David Moores, Robin Vera Gunning
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Publication number: 20130267588Abstract: The invention relates to hydroxytyrosol ethers derived from fatty alcohols and phenolic compounds of olive oil and the salts, solvates and hydrates thereof, which have an affinity for type 1 cannabinoid receptors (CB1) and which can: prevent the oxidation of low-density lipoprotein (LDL); and modulate the actions regulated by said receptor, such as inducing satiety, controlling intake and reducing body fat.Type: ApplicationFiled: December 19, 2011Publication date: October 10, 2013Applicants: FUNDACIO IMIM, FUNDACION INSTITUTO MEDITERRANEO PARA EL AVANCE DE LA BIOTECNOLOGIA Y LA INVESTIGACION SANITARIA, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICASInventors: Rafael De La Torre Fornell, Magin Farre Albaladejo, Maria Isabel Covas Planells, Montserrat Fito Colomer, Bruno Almeida Cotrim, Fernando Rodriguez De Fonseca, Juan Manuel Decara Del Olmo, Miguel Romero Cuevas, Jesus Joglar Tamargo, Pedro Clapes Saborit
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Publication number: 20130261083Abstract: The invention relates to additives enhancing the activity of certain insecticides, to significantly increase the effect of such insecticides when applied to the exterior foliage of a plant, thus increasing the kill rate of feeding insects that are normally protected deep within other tissue structures of the plant.Type: ApplicationFiled: December 9, 2011Publication date: October 3, 2013Applicant: Akzo Nobel Chemicals International B.V.Inventors: James Lyle Hazen, Jinxia Susan Sun
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Publication number: 20130253048Abstract: Provided is a composition that, even when used in a very small amount, has the effect of improving bone density and promoting bone growth, and has few side effects, and also provided are a pharmaceutical preparation for promoting bone growth, functional food product, and health food product containing the composition as an active ingredient. The composition can be obtained from any plant part selected from the group consisting of the bud, leaf, bark or wood of a plant belonging to the family Magnoliaceae. The composition comprises at least one selected from the group consisting of fargesin and physiologically acceptable salts, hydrates, and glycosides thereof. The pharmaceutical preparation, functional food product, and health food product comprising this composition as an active ingredient sufficiently improve bone density and promote bone growth, even when used in small amounts, and therefore realize preventive and/or therapeutic effects against bone disease etc. such as osteoporosis.Type: ApplicationFiled: January 11, 2013Publication date: September 26, 2013Applicant: ERINA CO., INC.Inventors: Midori ASAI, Young-Sil Lee, Naomi MASE, Bong-Keun CHOI, Byung-Yoon CHA, Takayuki YONEZAWA, Toshiaki TERUYA, Kazuo NAGAI, Je-Tae WOO
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Patent number: 8536222Abstract: The present invention provides new addition compounds of guanidinoacetic acid with malic acid, aspartic acid, ascorbic acid, succinic acid, pyruvic acid, fumaric acid, gluconic acid, alpha-ketoglutaric acid, pyroglutamic acid, 3-nicotinic acid, lactic acid, citric acid, maleic acid, acetic acid, formic acid, 2-hydroxybenzoic acid, L-carnitine, acetyl-L-carnitine, taurine, betaine, choline, methionine and lipoic acid as well as in the form of sodium, potassium or calcium guanidinoacetate. These addition compounds have improved physiological and therapeutic properties and are particularly suitable for use as dietary supplements, as animal feeds and in cosmetic or dermatological preparations in which especially the marked stability and good bioavailability of the addition compounds come to the fore.Type: GrantFiled: March 21, 2012Date of Patent: September 17, 2013Assignee: AlzChem AGInventors: Thomas Gastner, Hans-Peter Krimmer
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Patent number: 8536221Abstract: The invention relates to novel amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.Type: GrantFiled: February 6, 2009Date of Patent: September 17, 2013Assignee: AbbVie Inc.Inventors: Kathleen H. Mortell, Diana L. Nersesian, Michael R. Schrimpf, Chih-Hung Lee, Murali Gopalakrishnan
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Patent number: 8524767Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.Type: GrantFiled: February 12, 2010Date of Patent: September 3, 2013Assignee: Vertex Pharmaceuticals IncorporatedInventors: Mark T. Miller, Sara S. Hadida Ruah, Brian R. Bear, Peter D. J. Grootenhuis, Jason McCartney
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Publication number: 20130225531Abstract: A composition and method of treating Alzheimer's disease or a dementia of vascular origin are disclosed. The composition and method utilize an endothelin antagonist as the active agent to treat Alzheimer's disease or a dementia of vascular origin in mammals, including humans.Type: ApplicationFiled: December 19, 2012Publication date: August 29, 2013Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventor: The Board Of Trustees Of The University of Illinois
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Patent number: 8513301Abstract: A kind of piperphentonamine hydrochloride lyophilized powder for injection and a preparation method thereof. The injection is prepared by one portion of piperphentonamine hydrochloride, 2.5-30 parts of excipient and 400-600 parts of water for injection with pH 1.5-5.5 via freeze-drying. The excipient is mannitol, dextran, lactose, saccharose, polyethylene glycol, poloxamer, glycine, etc.; It is preferred that the injection comprises one part of piperphentonamine hydrochloride, 10 parts of mannitol and 500 parts of water for injection with pH 2.0-3.0. The product is prepared by adding said piperphentonamine hydrochloride and excipient into water for injection, heating at 40° C.-90° C., ultrasonic dissolving, degerming, individually packing, pre-freezing and multistage drying, and packaging. Individually packing into a tubular glass bottle with brown color is preferred. The appearance, color & luster and solubility of the injection are excellent, the stability is good and with long storage period.Type: GrantFiled: January 31, 2007Date of Patent: August 20, 2013Assignee: Guangzhou Zhongwei Biotechnology Ltd.Inventors: Huayin Wan, Rubing Li, Yonghe Li, Lijian Zhou, Tieqiu Liu, Xiaohui Zhong
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Patent number: 8507551Abstract: The disclosure provides a molecular genetic approach of targeted mutagenesis and heterologous expression, coupled with in vitro and in vivo models of bacterial pathogenesis, to demonstrate that the S. aureus pigment is a virulence factor and potential novel target for antimicrobial therapy.Type: GrantFiled: April 17, 2006Date of Patent: August 13, 2013Assignee: The Regents of the University of CaliforniaInventors: Victor Nizet, George Y. Liu
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Publication number: 20130202662Abstract: An O/W/O emulsion composition having at least one of lignan-class compounds dissolved in an internal oil phase is disclosed. This composition can be produced by a process comprising the steps of 1) dissolving at least one of lignan-class compounds in oil or fat to prepare a lignan-class compound dissolving liquid; 2) emulsifying the lignan-class compound dissolving liquid in a water phase to form an O/W emulsion; and 3) further emulsifying the O/W emulsion in an oil phase to prepare an O/W/O emulsion. This is a lignan-class compound containing composition that is enhanced in the amount of bodily absorption of lignan-class compounds.Type: ApplicationFiled: March 14, 2013Publication date: August 8, 2013Applicant: Suntory Holdings LimitedInventor: Suntory Holdings Limited
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Publication number: 20130172335Abstract: The present invention relates to compounds of formula I wherein R1a to R1e, R2, R3 and R5 are as defined in the description and claims and R4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.Type: ApplicationFiled: February 22, 2013Publication date: July 4, 2013Applicant: Hoffmann-La Roche Inc.Inventor: Hoffmann-La Roche Inc.
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Publication number: 20130157986Abstract: Pharmaceutical compounds and compositions are provided which are methylenedioxy phenolic compounds and their derivatives, along with methods of making them and methods of using them for therapeutic purposes. The compounds and compositions are advantageous in that they can be used to treat or prevent cardiovascular disease, vascular disease and/or inflammatory disease, as well as Type I and Type II Diabetes and Dyslipidemia patients at risk for hypertension, stroke, cardiovascular and renal disease.Type: ApplicationFiled: June 12, 2012Publication date: June 20, 2013Applicants: INVASC THERAPEUTICS, INC., OHIO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: SAMPATH PARTHASARATHY, SANJAY RAJAGOPALAN, DESIKAN RAJAGOPAL
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Patent number: 8466194Abstract: The present invention relates to spiroketal compounds that are useful in methods of treating or preventing protozoal infections, parasitic infections, bacterial infections, cell proliferative disorders and anti inflammatory disorders. The spiroketal compounds are also useful as immunosuppressive agents, and also in methods of controlling pests.Type: GrantFiled: August 11, 2011Date of Patent: June 18, 2013Assignee: EcoBiotics, LtdInventors: Paul Warren Reddell, Victoria Anne Gordon
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Publication number: 20130150436Abstract: A polyacetylenes and application thereof. The polyacetylenes is isolated from an extract of the sporophores of Antrodia Cinnamomea and has a function of inhibiting the production of nitric oxide. Therefore, the polyacetylenes can be used for preparing a pharmaceutical composition for anti-inflammation. The present invention also teaches the representative metabolites of the sporophores of Antrodia Cinnamomea, which can be used to evaluate the quality thereof.Type: ApplicationFiled: December 12, 2011Publication date: June 13, 2013Applicants: National Chung Hsing University, Taiwan Leader Biotech Corp.Inventor: SHENG-YANG WANG
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Patent number: 8450313Abstract: The present invention relates to compounds of formula I wherein R1a to R1e, R2, R3 and R5 are as defined in the description and claims and R4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.Type: GrantFiled: May 22, 2012Date of Patent: May 28, 2013Assignee: Hoffmann-La Roche Inc.Inventors: Daniel Hunziker, Christian Lerner, Werner Mueller, Ulrike Obst Sander, Philippe Pflieger, Pius Waldmeier
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Publication number: 20130116315Abstract: Provided is a composition for the prevention or treatment of obesity, dyslipidaemia, fatty liver or insulin resistance syndrome, comprising piperonal as an active ingredient. The composition of the present invention can be used to advantage as a drug or functional food composition which not only exhibits activity in the prevention or treatment of obesity, hyperlipidaemia or fatty liver but which also causes a significant reduction in fasted blood sugar and blood insulin concentration and hence has an effect in improving Type-2 diabetes or insulin resistance and also improves metabolic disorder which is closely associated therewith.Type: ApplicationFiled: November 19, 2010Publication date: May 9, 2013Inventor: Tae Sun Park
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Publication number: 20130115261Abstract: Use of formulations comprising polyurea microcapsules obtainable by interfacial polymerization of diphenylmethylen-4,4?-diisocyanate (MDI), optionally in admixture with polymethylenepolyphenylisocyanate (PAPI), said formulations having a prolonged knockdown and killing effect longer than at least 3 months, preferably at least of 6 months, still more preferably at least of 9 months from the application, wherein the microcapsules comprise: an active principle selected from the pyrethroid and/or neonicotinoid classes, synergizing agents selected between PEO and Verbutin, the concentration of the active principle in the microcapsule as % by weight on the total of the microcapsule is comprised between to and 60% the average diameter of the microcapsules is comprised between 2 and 50 ?m.Type: ApplicationFiled: November 1, 2012Publication date: May 9, 2013Applicants: SIPCAM S. P. A., ENDURA S. P. A.Inventors: ENDURA S. P. A., SIPCAM S. P. A.
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Patent number: 8436013Abstract: The invention features compositions and methods that are useful for treating or preventing AAT deficiency and associated conditions. In addition, the invention provides methods for identifying compounds useful for treatment of AAT deficiency and associated conditions.Type: GrantFiled: July 9, 2009Date of Patent: May 7, 2013Assignee: University of Florida Research Foundation, Inc.Inventors: Chen Liu, David A. Ostrov
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Publication number: 20130102660Abstract: The use of cubebin, dibenzylbutyrolactolic lignan, its semi-synthetic and synthetic derivatives for the treatment of erectile dysfunction is shown and disclosed.Type: ApplicationFiled: December 21, 2009Publication date: April 25, 2013Applicant: ACEF S.A.Inventors: Sérgio Albuquerque, Jáiro Kenupp Bastos, Paulo Sérgio Calefi, Katia Jorge Ciuffi, Wilson Roberto Cunha, Rosangela da Silva de Laurentiz, Rodrigo Lucarini, Eduardo José Nassar, Ademar Alves da Silva Filho, Márcio Luís Andrae e Silva
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Publication number: 20130090367Abstract: This application relates to the modulation of host cell factors required for influenza virus replication. The application relates to compounds, including nucleic acid compounds (such as, e.g., small interfering RNAs (siRNAs)) and small molecules, that target human host cell factors involved in influenza virus replication, and the use of such compounds for modulating influenza virus replication and as antiviral agents. The application also relates to methods of treating an influenza virus infection and methods of treating or preventing a symptom or disease associated with influenza virus infection, comprising administering to a subject a composition comprising a compound, such as a nucleic acid compound (e.g., an siRNA) or small molecule, that targets a human host cell factor involved in influenza virus replication.Type: ApplicationFiled: December 10, 2010Publication date: April 11, 2013Inventors: Megan Shaw, Peter Palese, Adolfo Garcia-Sastre, Silke Stertz, John Young, Renate König, Sumit Chanda
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Publication number: 20130079336Abstract: Methods for terminating, preventing, and/or treating status epilepticus are generally provided. The method can include administering a prophylactically or therapeutically effective amount of stiripentol or a related compound thereof to an individual in need of treatment of status epilepticus. The individual can be in need of treatment of prolonged status epilepticus, refractory status epilepticus, and/or benzodiazepine-resistant status epilepticus.Type: ApplicationFiled: September 19, 2012Publication date: March 28, 2013Applicant: UNIVERSITY OF SOUTH CAROLINAInventor: University of South Carolina
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Publication number: 20130079396Abstract: The present invention relates to benzylidene indanones of general formula 1. The compounds exhibited tubulin polymerisation inhibition. A series of compounds 2-benzylidene 3-(3,4,5-trimethoxyphenyl) indanones having general formulae 1 were synthesized from gallic acid through a chemical process. 2-(3,4-Methylenedioxybenzylidine), 3-(3,4,5-trimethoxyphenyl), 4,5,6-trimethoxyindanone (8), a representative compound of this series possessing the molecular formulae C29H28O9, was synthesized from gallic acid and exhibits potent anticancer activity. Compound 8 was evaluated for acute oral activity in Swiss albino mice and found to be safe up to 300 mg/kg body weight. The anticancer activity of the compounds has been determined, in order to obtain new potent and cost effective molecules using an in vitro cytotoxicity assay.Type: ApplicationFiled: September 20, 2012Publication date: March 28, 2013Applicant: Council of Scientific and Industrial ResearchInventor: Council of Scientific and Industrial Research
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Publication number: 20130059852Abstract: Some embodiments of this invention include methods for treating disease and methods for administering a compound of Formula (I). In some aspects of the invention, diseases can be treated by administration of compositions comprising a compound of Formula (I). Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I).Type: ApplicationFiled: April 8, 2011Publication date: March 7, 2013Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.Inventors: John O. Trent, Jason B. Meier, Kelby B. Napier
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Publication number: 20130039863Abstract: Methods of controlling the feeding and/or breeding behavior of a target insect are disclosed in which a host plant is provided a substantial distance from a plant of interest, chemical attractant that induces the target insect to lay eggs on the host plant is applied to the host plant, application of the chemical attractant to the host plant is repeated as required to induce residual target-insect populations to lay eggs on the host plant, and wherein the behavior is controlled when a substantial number of off-spring belonging to subsequent generations themselves mature and display a preference for laying eggs on the same type of host plant on which they were reared without further application of the chemical attractant is provided. Also disclosed are methods of deterring target insect feeding and breeding on plants of interest by applying toxic plant extract to the plants of interest.Type: ApplicationFiled: January 28, 2011Publication date: February 14, 2013Applicant: University of the West Indies a Regional Institution established by Royal CharterInventors: Trevor Herbert Yee, Charah Tabetha Watson, Eric Garraway
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Patent number: 8362305Abstract: The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.Type: GrantFiled: July 21, 2009Date of Patent: January 29, 2013Assignee: Unigen, Inc.Inventors: Sandip K. Nandy, Jiyun Liu, Alexandre Mikhailovitch Nesterov, Carmen Hertel, Abeysinghe A. Padmapriya
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Publication number: 20130012477Abstract: Derivatives of dillapiol, sesamol and related monolignans having the following general formula: These compounds have synergistic properties, inhibit cytochrome P450 enzymes such as human CYP3A4, and can be used as pesticide synergists or pharmaco-enhancers. Accordingly, methods for increasing the efficacy and/or bioavailability of a pharmaceutically active agent and for increasing the potency of a pesticide are described, as are synergistic pesticidal and pharmaceutical compositions.Type: ApplicationFiled: May 11, 2012Publication date: January 10, 2013Applicants: HER MAJESTY THE QUEEN IN RIGHT OF CANADA AS REPRESENTED BY THE MINISTER OF HEALTH, UNIVERSITY OF OTTAWAInventors: John Thor Arnason, Tony Durst, Brian Foster
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Patent number: 8337871Abstract: The present invention provides a new insecticide formulation based on cyclodextrin characterized in that the active substance (insecticide and/or insect growth regulator), and a compound synergistic with the active substance, are complexed simultaneously with cyclodextrin. The formulation presents as a solid or as a solid/oil composition, and is soluble or completely emulsifiable in water or in aqueous mixtures of water miscible solvents. The activity of the present formulations was found to be greater than that of a mixture of the two active components each complexed separately with cyclodextrin, for the same dose. The preparation process of said formulation and its use as an insecticide in agriculture, for veterinary use or to eliminate household insects, are further aspects of the present invention.Type: GrantFiled: October 26, 2004Date of Patent: December 25, 2012Assignee: Endura S.p.A.Inventors: Oreste Piccolo, Giovanna Delogu, Valerio Borzatta
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Patent number: 8338443Abstract: The use of a compound of formula I wherein Y is a single bond, C?O, C?S or S(O)m, where m is 0, 1 or 2; the ring is a 6-membered aromatic or is a 5 or 6 membered heteroaromatic ring; Z and Z? are joined by a single or a double bond and are ?C— or —N— provided that both are not N; Ra, R1, R2, R3, R3a, R4 and R8 are specified organic groups; n is 2, 3 or 4 and p is 0-4; or salts or N-oxides thereof or compositions containing them in controlling insects, acarines, nematodes or molluscs. Novel compounds are also provided.Type: GrantFiled: December 6, 2006Date of Patent: December 25, 2012Assignee: Syngenta Crop Protection LLCInventors: Jérôme Cassayre, Peter Maienfisch, Fredrik Cederbaum, Louis-Pierre Molleyres
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Publication number: 20120308671Abstract: Nose ointment for the prophylaxis of inhalation allergic reactions comprising at least one mixture of saturated hydrocarbons characterized in that the at least one mixture of saturated hydrocarbons has a viscosity by the DIN 51 562 method of >6 mm2/s (100° C.).Type: ApplicationFiled: May 14, 2012Publication date: December 6, 2012Applicant: PHYT-IMMUN GmbHInventor: Peter Theiss
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Publication number: 20120302632Abstract: Compositions for the treatment of symptoms of inflammatory disorders may include gamma-linolenic acid or dihomogammalinolenic acid, an inhibitor of ?5 desaturase, and optionally stearidonic acid or ?-3 arachidonic acid. Preferred formulations may be in the form of a good tasting,.preferably milk or fruit based drink, or a dried powder. Compositions reduce inflammation and inhibit increase in serum arachidonic acid associated with gamma-linolenic acid.Type: ApplicationFiled: August 6, 2012Publication date: November 29, 2012Inventor: Floyd H. Chilton
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Patent number: 8309608Abstract: The present invention relates to the use of compounds which enhance the transcription of endothelial nitric oxide synthase (eNOS) for treating stem and progenitor cells in the cell therapy of patients with ischemic heart diseases such as coronary heart disease or ischemic cardiomyopathy. Treatment of such cells which are isolated from bone marrow, for example, with an eNOS transcription enhancer prior to their administration improves their functional activity and ameliorates neovascularization of the heart and cardiac regeneration.Type: GrantFiled: November 2, 2004Date of Patent: November 13, 2012Assignee: Sanofi-Aventis Deutschland GmbHInventors: Andreas Zeiher, Stefanie Dimmeler, Christopher Heeschen, Hartmut Ruetten
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Publication number: 20120282342Abstract: A method for preparing polysaccharide nanocomposite particles is provided. The method comprises providing a first solution comprising an active component and a polysaccharide; adding a cross-linking agent to the first solution to provide a second solution; and allowing the second solution to conduct the reaction to form polysaccharide nanocomposite particles. The polysaccharide nanocomposite particles thus prepared show good coating ratio and enhanced applicability. Also provided is a method for inducing cancer cell apoptosis in a subject, comprising administrating to the subject an effective amount of the polysaccharide nanocomposite particles.Type: ApplicationFiled: October 26, 2011Publication date: November 8, 2012Inventors: Chih-Wei Chou, Yueh-Hsiung Kuo, Jen-Ming Yang, Chin-Heng Yang
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Publication number: 20120277252Abstract: The present invention relates generally to compounds providing antibacterial therapeutic agents and preparations, and related methods of using and making antibacterial compounds. Antibacterial compounds of the present invention include chalcone, alkylpyrimidine, aminopyrimidine and cyanopyridine compounds and derivatives thereof exhibiting minimum inhibitory concentrations (MIC) similar to or less than conventional antibacterial compounds in wide use. For example, the present invention provides chalcone and cyanopyridine compounds, and derivatives thereof, exhibiting high antibacterial activities having multiple electron withdrawing group substituents, such as halogens and fluorinated alkyl groups, and optionally having hydroxyl and/or alkoxyl groups substituents.Type: ApplicationFiled: July 6, 2012Publication date: November 1, 2012Inventors: Helen E. Blackwell, Matthew D. Bowman, Jennifer C. O'Neill, Joseph R. Stringer
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Publication number: 20120251624Abstract: The invention relates to a novel class of inhibitors of arachidonic acid formation that can be useful for treating inflammatory conditions. Specifically, the invention relates to derivatives of sesamol that confer lower toxicity and increased circulatory lifetimes than pure sesamol.Type: ApplicationFiled: December 9, 2011Publication date: October 4, 2012Inventor: Barry D. SEARS