Phosphorus Containing Patents (Class 514/47)
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Patent number: 12201723Abstract: An object of the present invention is to provide a combined pharmaceutical formulation obtained by combining a liposome composition and an immune checkpoint inhibitor, in which gemcitabine is encapsulated in a dissolved state in liposomes in the liposome composition. According to the present invention, there is provided a pharmaceutical formulation including (A) a liposome composition in combination with (B) an immune checkpoint inhibitor, in which the liposome composition includes liposomes each having an inner water phase, and an aqueous solution constituting an outer water phase and having the liposomes dispersed therein, gemcitabine is encapsulated in a dissolved state in the liposomes, and the liposome composition and the immune checkpoint inhibitor are administered simultaneously or sequentially.Type: GrantFiled: December 17, 2020Date of Patent: January 21, 2025Assignee: FUJIFILM CorporationInventors: Takashi Komori, Tadaaki Ioroi, Takeshi Matsumoto, Yasuyuki Izumi
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Patent number: 12186364Abstract: The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.Type: GrantFiled: March 10, 2022Date of Patent: January 7, 2025Assignee: Genevive, Inc.Inventors: Andrew Wonhee Han, Andrew W. Goodyear, Tarunmeet Gujral, Todd Zachary DeSantis, Karim Dabbagh
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Patent number: 12171777Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.Type: GrantFiled: May 1, 2023Date of Patent: December 24, 2024Assignee: Takeda Pharmaceutical Company LimitedInventors: Masato Yoshikawa, Morihisa Saitoh, Taisuke Kato, Yayoi Nakayama, Tomohiro Seki, Yasuo Nakagawa, Yusuke Tominari, Masaki Seto, Yusuke Sasaki, Masanori Okaniwa, Tsuneo Oda, Akito Shibuya, Kosuke Hidaka, Zenyu Shiokawa, Shumpei Murata, Atsutoshi Okabe, Yoshihisa Nakada, Michiyo Mochizuki, Brian Scott Freeze, Taisuke Tawaraishi, Yasufumi Wada, Paul D. Greenspan
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Patent number: 12161626Abstract: Methods and compositions for treating acute myeloid leukemia and diffuse large B cell lymphoma using combinations of venetoclax and indolinone derivatives are provided.Type: GrantFiled: March 28, 2022Date of Patent: December 10, 2024Assignee: Oncternal Therapeutics, Inc.Inventors: Brian Lannutti, Katayoun Jessen, James Bradley Breitmeyer
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Patent number: 12159720Abstract: A computer implemented method for prescribing optimized medical interventions includes retrieving a patient's updated electronic medical record (EMR) and mapping the diagnosis of the patient to a medical treatment database to select a plurality of likely medical intervention choices based on a score exceeding a defined threshold score. The method includes determining a rank order of the selected plurality of medical intervention choices by comparing simulation outcomes for each choice executed by the medical predictive algorithm, on respective choices among each of the selected likely medical interventions. The method also includes receiving by the patient's physician or patient's electronic medical record database, a rank order of recommended medical intervention choices including possible options and associated metrics based on an accepted level of simulated outcome.Type: GrantFiled: June 6, 2022Date of Patent: December 3, 2024Assignee: DasiSimulations, LLCInventors: Lakshmi Prasad Dasi, Theresa L. Sirset
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Patent number: 12054606Abstract: A method for discriminating a polyvinyl alcohol resin film containing a polyvinyl alcohol resin in which all or a part of carbon is derived from bio-derived ethylene from a polyvinyl alcohol resin film containing only a polyvinyl alcohol resin derived only from fossil fuel-derived ethylene by measuring an abundance ratio 14C/C of carbon 14 (14C) in total carbon.Type: GrantFiled: July 20, 2022Date of Patent: August 6, 2024Assignee: KURARAY CO., LTD.Inventors: Osamu Kazeto, Yasutaka Inubushi
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Patent number: 11918586Abstract: The present invention is relates to a compound of formula (I), wherein X1, X2 and X3 are, independently of each other, N or CH; with the proviso that at least two of X1 X2 and X3 are N; Y is N or CH; W is H or F; with the proviso that when W is F, then X1, X2 and X3 are N; R1 and R2 are independently of each other (i) a morpholinyl of formula (II) wherein the arrow denotes the bond in formula (I); and wherein R3 and R4 are independently of each other H, C1-C3alkyl optionally substituted with one or two OH, C1-C2fluoroalkyl, C1-C2alkoxy, C1alkoxyC1-C3alkyl, CN, or C(O)O—C1-C2alkyl; or R3 and R4 form together a bivalent residue —R5R6— selected from C1-C3alkylene optionally substituted with 1 to 4 F, —CH2—O—CH2—, —CH2—NH—CH2—, or any of the structures wherein the arrows denote the bonds in formula (II); or (ii) a saturated 6-membered heterocyclic ring Z selected from thiomorpholinyl and piperazinyl, optionally substituted by 1 to 3 R7; wherein R7 is independently at each occurrence C1-C3alkyl optionally substituType: GrantFiled: March 26, 2021Date of Patent: March 5, 2024Assignees: TORQUR AG, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Doriano Fabbro, Paul Hebeisen, Petra Hillmann-Wuellner, Anton Stuetz, John T. Seykora, Florent Beaufils
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Patent number: 11858957Abstract: The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating or preventing cancer using the novel heterocyclic compounds of the invention.Type: GrantFiled: June 28, 2021Date of Patent: January 2, 2024Assignee: ANTENGENT THERAPEUTICS LIMITEDInventors: Lijing Chen, Roland Joseph Billedeau, Jim Li
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Patent number: 11787922Abstract: Disclosed herein is a polymer composition comprising an effective amount of a hydrophobically-modified polymer having functional groups along the backbone occupied by a fatty anhydride moiety. The polymer composition has a potent hemostatic action by gelling blood upon contact, and is suitable for treating internal and external bleeds. As disclosed herein, the modified polymer can be generated without the use of toxic reagents that would require removal from the product. Further, compositions are shelf stable even in a flowable form. That is, the hydrophobic grafts are not lost under product storage conditions (e.g., room temperature storage).Type: GrantFiled: January 31, 2022Date of Patent: October 17, 2023Assignee: Medcura, Inc.Inventor: Matthew Dowling
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Patent number: 11707472Abstract: The present disclosure is directed to methods of treating fibrotic conditions by administration of TR? agonists. The disclosure provides methods wherein the abnormal deposition of extracellular matrix components, such as collagen, keratin, or elastin, is reduced, either through interaction of TR? agonists with TGF-?-dependent inflammatory pathways, or by other mechanisms, thereby ameliorating fibrotic symptoms.Type: GrantFiled: June 4, 2018Date of Patent: July 25, 2023Assignee: Viking Therapeutics, Inc.Inventors: Brian Lian, Hiroko Masamune, Geoffrey E. Barker
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Patent number: 11666593Abstract: The present invention provides a composition comprising adenosine or adenosine triphosphate (ATP) acting as an absorption enhancer when combined with a nutritional material(s) such as nutrients, protein, peptides, vitamins, phytochemicals, minerals, fatty acids, or amino acids or a drug. Methods of administering ATP or adenosine to improve the bioavailability of a nutritional material(s) such as nutrients, protein, peptides, vitamins, phytochemicals, minerals, fatty acids, or amino acids or a drug are described.Type: GrantFiled: September 4, 2020Date of Patent: June 6, 2023Inventors: John Rathmacher, Lisa Pitchford, Shawn Baier, Larry Kolb, Naji Abumrad, Matthew Legge
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Patent number: 11576922Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.Type: GrantFiled: August 17, 2021Date of Patent: February 14, 2023Assignee: ORIC PHARMACEUTICALS, INC.Inventors: Xiaohui Du, John Eksterowicz, Valeria R. Fantin, Erica L. Jackson, Daqing Sun, Qiuping Ye, Jared Moore
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Patent number: 11510934Abstract: A method for reducing or maintaining platelet inhibition in a patient by administering cangrelor prior to an invasive procedure is described. The method of this invention can be used for patients in need of antiplatelet therapy or at risk of thrombosis. The method can further be used in patients who were previously treated with long-acting platelet inhibitors without increasing the risk of excessive bleeding.Type: GrantFiled: July 14, 2020Date of Patent: November 29, 2022Assignee: Chiesi Farmaceutici S.p.A.Inventors: Lisa Ruderman Chen, Simona Skerjanec, Dawn Bell, Jayne Prats, Meredith Todd
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Pharmaceutical or cosmetic composition for preventing or treating hair loss or promoting hair growth
Patent number: 11471474Abstract: A pharmaceutical composition or a cosmetic composition treating hair loss, or promoting hair growth is described. The composition comprises cyclic adenosine diphosphate ribose (cADPR) or derivatives thereof or comprises at least one selected from one or more naturally occurring amino acid or salt thereof, one or more growth factor, noggin, one or more saturated or unsaturated C8 to C18 long chain fatty acid or salt thereof, one or more active factor and one or more water-soluble vitamin or salt thereof in addition to cyclic ADP ribose. The composition exhibits an excellent effect of treating hair loss and promoting hair growth and can be safely used regardless of sex or age.Type: GrantFiled: March 28, 2019Date of Patent: October 18, 2022Inventor: Mi Gyoung Yang -
Patent number: 11376272Abstract: In one aspect, the invention provides methods of increasing immune response by administering postcellular signaling factors produced by cells exposed to a stress condition. In one aspect, the invention provides methods of increasing immune response by administering in combination (a) a Stimulator of Interferon Genes (STING) agonist and (b) a purinergic receptor agonist. The increase in immune response may be used, for example, for treatment of infection or cancer. The invention also provides screening assays for identification of compounds that induce production of postcellular signaling factors which are also immunostimulatory agents. The invention further provides methods for identifying postcellular signaling factors with immunostimulatory activity. In another aspect, the invention provides methods of decreasing immune response by administering to a cell, tissue or subject a purinergic receptor antagonist alone or in combination with a Stimulator of Interferon Genes (STING) antagonist.Type: GrantFiled: May 6, 2021Date of Patent: July 5, 2022Assignee: Flagship Pioneering Innovations V, Inc.Inventors: Anthony Michael Barsotti, Alexandra Masu Cantley, Jason Park, Douglas Gowers Cole
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Patent number: 11278504Abstract: A method of treating lionfish envenomation; it includes administering to a subject a therapeutically effective amount of a P2X3 receptor antagonist; topical compositions for treating lionfish envenomation are also described.Type: GrantFiled: April 23, 2020Date of Patent: March 22, 2022Inventors: Reza Sharif Naeini, Stephanie Mouchbahani Constance
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Patent number: 11273198Abstract: The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.Type: GrantFiled: May 4, 2018Date of Patent: March 15, 2022Assignee: Second Genome, Inc.Inventors: Andrew Wonhee Han, Andrew W. Goodyear, Tarunmeet Gujral, Todd Zachary DeSantis, Karim Dabbagh
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Patent number: 11060715Abstract: The technology relates in part to methods and compositions for ex vivo proliferation and expansion of epithelial cells.Type: GrantFiled: July 30, 2019Date of Patent: July 13, 2021Assignee: PROPAGENIX INC.Inventor: Chengkang Zhang
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Patent number: 10993947Abstract: The present invention is relates to a compound of formula (I), wherein X1, X2 and X3 are, independently of each other, N or CH; with the proviso that at least two of X1, X2 and X3 are N; Y is N or CH; W is H or F; with the proviso that when W is F, then X1, X2 and X3 are N; R1 and R2 are independently of each other (i) a morpholinyl of formula (II) wherein the arrow denotes the bond in formula (I); and wherein R3 and R4 are independently of each other H, C1-C3alkyl optionally substituted with one or two OH, C1-C2fluoroalkyl, C1-C2alkoxy, C1-C2alkoxyC1-C3alkyl, CN, or C(O)O—C1-C2alkyl; or R3 and R4 form together a bivalent residue —R5R6— selected from C1-C3alkylene optionally substituted with 1 to 4 F, —CH2—O—CH2—, —CH2—NH—CH2—, or any of the structures wherein the arrows denote the bonds in formula (II); or (ii) a saturated 6-membered heterocyclic ring Z selected from thiomorpholinyl and piperazinyl, optionally substituted by 1 to 3 R7; wherein R7 is independently at each occurrence C1-Type: GrantFiled: May 17, 2017Date of Patent: May 4, 2021Assignee: TORQURInventors: Doriano Fabbro, Paul Hebeisen, Petra Hillmann-Wuellner, Anton Stuetz, John T. Seykora, Florent Beaufils
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Patent number: 10987372Abstract: It is an object of the present invention to provide a novel therapeutic agent for hepatoma viruses. Specifically, the present invention relates to an anti-hepatoma virus agent, containing as an active ingredient a compound represented by the following Formula (I) or a pharmaceutically acceptable salt thereof: (wherein R1 is fluorine or hydrogen).Type: GrantFiled: March 10, 2017Date of Patent: April 27, 2021Assignees: KAGOSHIMA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, DAIKIN INDUSTRIES, LTD.Inventors: Masanori Ikeda, Midori Takeda, Masanori Baba, Nobuyuki Kato
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Patent number: 10960006Abstract: A topical formulation comprising (a) a therapeutically effective amount of tofacitinib; (b) at least one solvent; and (c) optionally one or more other pharmaceutically acceptable excipients is provided. Also provided is a method for treating and/or preventing autoimmune diseases in a subject administering said topical formulation.Type: GrantFiled: January 22, 2019Date of Patent: March 30, 2021Assignee: TWi Pharmaceuticals, Inc.Inventors: Chih-Ming Chen, Guang-Wei Lu, Ling-Ying Liaw, Fan-Lun Liu, Shih-Fen Liao, Chou-Hsiung Chen, Yu-Han Kao, Yu-Yin Chen
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Patent number: 10953030Abstract: Cytidine nucleoside analogues of Formula I, wherein the variables are as described herein, in combination with uridine nucleoside analogues of Formula II, wherein the variables are as described herein, produce a synergistic effect on the inhibition of HCV polymerase.Type: GrantFiled: August 5, 2019Date of Patent: March 23, 2021Assignee: Riboscience LLCInventors: Mark Smith, Klaus G. Klumpp
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Patent number: 10919922Abstract: Antiviral compounds comprising prodrugs with differing side chains derived from a tyrosine substance in the form of a tyrosine amide in which the amide substituent side chain is an alkyl ether, thioether, or alkene. Embodiments of the compounds have a range of effective lipophilicity values allowing variation in aqueous solubility, oral bioavailability, cell permeability and in vivo activation properties. The embodiments have promoieties derived from a single amino acid, which are expected to have low toxicity. The features described above also make possible a novel “precision medicine” approach to treatment of viral infections, whereby the prodrug variations can be exploited to match optimal activation of the prodrug to a given patient or strain of virus.Type: GrantFiled: October 31, 2017Date of Patent: February 16, 2021Assignee: University of Southern CaliforniaInventors: Charles E. McKenna, Boris A. Kashemirov, Jaijun Fan, Jinglei Lyu
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Patent number: 10906928Abstract: A hemi-sulfate salt of the structure: to treat a host infected with hepatitis C, as well as pharmaceutical compositions and dosage forms, including solid dosage forms, thereof.Type: GrantFiled: November 18, 2019Date of Patent: February 2, 2021Assignee: Atea Pharmaceuticals, Inc.Inventors: Adel Moussa, Jean-Pierre Sommadossi
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Patent number: 10906929Abstract: This invention relates to derivatives of cladribine of Formula (I). The compounds are phosphoramidate derivatives in which the phosphoramidate moiety is situated on the 3?-hydroxyl group of cladribine. The invention also relates to pharmaceutical formulations of the cladribine derivatives and their use in methods of treatment. The compounds are useful in the treatment of cancer.Type: GrantFiled: May 31, 2017Date of Patent: February 2, 2021Assignee: NuCana plcInventors: Hugh Griffith, Michaela Serpi, Magdalena Slusarczyk, Christopher McGuigan
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Patent number: 10744149Abstract: A method for reducing or maintaining platelet inhibition in a patient by administering cangrelor prior to an invasive procedure is described. The method of this invention can be used for patients in need of antiplatelet therapy or at risk of thrombosis. The method can further be used in patients who were previously treated with long-acting platelet inhibitors without increasing the risk of excessive bleeding.Type: GrantFiled: March 18, 2019Date of Patent: August 18, 2020Assignee: Chiesi Farmaceutici S.p.A.Inventors: Lisa Ruderman Chen, Simona Skerjanec, Dawn Bell, Jayne Prats, Meredith Todd
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Patent number: 10723753Abstract: Described herein are compounds of Formulae (I)-(II), and pharmaceutically acceptable salts, and pharmaceutical compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases such as cancers (e.g., lung cancer, large bowel cancer, pancreas cancer, biliary tract cancer, or endometrial cancer), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases in a subject.Type: GrantFiled: March 13, 2014Date of Patent: July 28, 2020Assignee: Dana-Farber Cancer Institute, Inc.Inventors: Nathanael Gray, Sang Min Lim, Hwan Geun Choi, Kenneth Dale Westover, Matthew Meyerson
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Patent number: 10716766Abstract: A method of treating a disease state or condition in humans via topical brainstem afferent stimulation therapy via the administration of a cannabinoid drug(s) to the back of the neck of a human patient to provide regional neuro-affective therapy is disclosed. In certain preferred embodiments, the cannabinoid drug(s) are not psychoactive or substantially not psychoactive. In certain embodiments, the cannabinoid drug(s) are incorporated into a pharmaceutically acceptable topical carrier, e.g., a cream. In certain preferred embodiments, the cannabinoid drug(s) comprises cannabidiol.Type: GrantFiled: March 2, 2016Date of Patent: July 21, 2020Assignee: AfGin Pharma, LLCInventor: Ronald Aung-Din
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Patent number: 10702479Abstract: The invention relates to pharmaceutical formulation in form of a film-coating tablet comprising sembragiline or a salt thereof.Type: GrantFiled: September 26, 2017Date of Patent: July 7, 2020Assignee: Hoffmann-La Roche Inc.Inventors: Zoltan Mathe, Lene Maurer, Valérie Verhoeven
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Patent number: 10683321Abstract: Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 4?-OR nucleosides of Formula I: or a pharmaceutically acceptable salt thereof, wherein Base, PD, R, Z1, Z2, Z3, and Z4 are as defined herein.Type: GrantFiled: December 17, 2014Date of Patent: June 16, 2020Assignee: Idenix Pharmaceuticals LLCInventors: David Dukhan, Cyril B. Dousson, Adel M. Moussa, Benjamin Alexander Mayes, Alistair James Stewart
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Patent number: 10654884Abstract: Provided are novel purine nucleoside/nucleotide analogues compounds, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are inhibitors of CD73 and are useful in the treatment of cancer.Type: GrantFiled: April 23, 2015Date of Patent: May 19, 2020Assignee: Boehringer Ingelheim International GmbHInventors: Salvacion Cacatian, David A. Claremon, Lanqi Jia, Angel Morales-Ramos, Suresh B. Singh, Shankar Venkatraman, Zhenrong Xu, Yajun Zheng
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Patent number: 10654883Abstract: The present invention relates to inorganic salts of nicotinic acid mononucleotides and compositions of Formula I, useful in the treatment of disorders and diseases associated with deficiencies in NAD+: wherein A, M1, M2, k, R1, R2, and R3 are as described herein.Type: GrantFiled: April 3, 2019Date of Patent: May 19, 2020Assignees: Jumpstart Fertility Pty Ltd, Life Biosciences, Inc.Inventors: Michel Wathier, Roland Dolle, Sebastian Mario Marcuccio, Rohan David Joyce, Simon Tucker
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Patent number: 10596094Abstract: The present invention provides compositions and methods for reducing skin pigmentation. The invention comprises inhibitors of sialyltransferase, inhibitors of oligosaccharide formation or oligosaccharide activity, and methods of using such inhibitors. In certain embodiments, the invention comprises inhibiting the formation and/or activity of Neu5Ac(?2,6)Gal/GalNAc-containing oligosaccharides.Type: GrantFiled: March 7, 2014Date of Patent: March 24, 2020Assignee: YALE UNIVERSITYInventor: John Mason Pawelek
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Patent number: 10570167Abstract: The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating or preventing cancer using the novel heterocyclic compounds of the invention.Type: GrantFiled: December 21, 2017Date of Patent: February 25, 2020Assignee: Calithera Biosciences, Inc.Inventors: Roland J. Billedeau, Jim Li, Lijing Chen
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Patent number: 10428105Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions for treatment of viral infections, especially HRV.Type: GrantFiled: May 8, 2018Date of Patent: October 1, 2019Assignee: Novartis AGInventors: Martijn Fenaux, Oliver Saunders, Fumiaki Yokokawa, Weidong Zhong
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Patent number: 10385091Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.Type: GrantFiled: September 28, 2017Date of Patent: August 20, 2019Assignees: Memorial Sloan Kettering Cancer Center, The Rockefeller University, Rutgers, The State University of New Jersey, University of BonnInventors: Dinshaw J. Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
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Patent number: 10335412Abstract: The present invention relates to adenine which is useful to activate AMP-activated protein kinase (AMPK) and the use of adenine in the prevention or treatment of conditions or disease and thereby prevent or treat conditions or diseases which can be ameliorated by AMPK in a mammal.Type: GrantFiled: April 10, 2013Date of Patent: July 2, 2019Assignee: ENERGENESIS BIOMEDICAL CO., LTDInventors: Han-Min Chen, Cheng-Yi Kuo, Chun-Fang Huang, Jiun-Tsai Lin
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Patent number: 10160779Abstract: A process for preparing a compound of formula (I) or a salt thereof, the process comprising providing a compound of formula (III) wherein PG is an inert electron withdrawing hydroxyl protecting group, reacting the compound of formula (III) with a fluorinating agent, obtaining a compound of formula (II) and deprotecting the compound of formula (II).Type: GrantFiled: June 22, 2016Date of Patent: December 25, 2018Assignee: Sandoz AGInventors: Olga Schöne, Thorsten Wilhelm
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Patent number: 10143652Abstract: Provided herein are methods for preparing liposomes and uses thereof. In certain embodiments, liposomes are prepared without using heat, organic solvents, proteins, and/or inorganic salts in the process. In certain embodiments, the liposomal preparation contains one or more active agents. In certain embodiments, the liposomal preparations are used in the treatment of diseases or disorders.Type: GrantFiled: August 2, 2016Date of Patent: December 4, 2018Assignee: CuriRx Inc.Inventors: Indu Javeri, Kaliappanadar Nellaiappan
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Patent number: 10111904Abstract: Sterile micron-sized gold particles contained in capped vials, a kit of part including the vial and a liquid capable of suspending the particles, as well as their preparation, medical devices or medicaments prepared by their preparation as well as uses thereof in treating inflammation. Also, gold coated implants preferably for use in combination with the medical devices.Type: GrantFiled: January 8, 2014Date of Patent: October 30, 2018Assignee: Berlock ApSInventor: Gorm Danscher
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Patent number: 10092649Abstract: The application discloses nucleoside derivatives of Formula I as inhibitors of Influenza RNA replication. In particular, the application discloses the use of purine and pyrimidine nucleoside derivatives of Formula I as inhibitors of Influenza RNA replication and pharmaceutical compositions containing such compounds.Type: GrantFiled: June 20, 2016Date of Patent: October 9, 2018Assignee: Riboscience LLCInventors: Mark Smith, Klaus G. Klumpp
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Patent number: 10092590Abstract: The present invention provides a composition comprising HMB and ATP. Methods of administering HMB and ATP to an animal are also described. HMB and ATP are administered to increase power and strength. The combination of HMB and ATP together has a synergistic effect, which results in a surprising and unexpected level of improvement in power and strength. HMB and ATP are also administered to increase lean body mass and muscle hypertrophy and to prevent typical declines in performance that are characteristic of overreaching.Type: GrantFiled: September 10, 2013Date of Patent: October 9, 2018Assignee: Metabolic Technologies, Inc.Inventors: Shawn Baier, Larry Kolb, John Rathmacher
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Patent number: 10086009Abstract: This invention provides methods of enhancing brain development; increasing or enhancing intelligence; increasing or enhancing synthesis and levels of phospholipids, synapses, synaptic proteins, and synaptic membranes by a neural cell or brain cell, comprising contacting a subject or a pregnant or nursing mother thereof with a composition comprising an omega-3 fatty acid, an omega-6 fatty acid, and/or uridine, a metabolic precursor thereof, or a combination thereof.Type: GrantFiled: May 23, 2006Date of Patent: October 2, 2018Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGIESInventors: Richard J. Wurtman, Ingrid Richardson
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Patent number: 10080784Abstract: The use of a purine nucleoside phosphorylase or nucleoside hydrolase or a vector encoding expression of one of these enzymes is detailed along with the use of a prodrug cleaved by the purine nucleoside phosphorylase or nucleoside hydrolase for the preparation of a direct injection inhibition of replicating or non-replicating targeted cells. The targeted cells do not normally express the introduced purine nucleoside phosphorylase or nucleoside hydrolase. The enzyme and prodrug are amenable to intermixing and injection as a single dose or as separate injection or administration to the targeted cells. The substance and prodrug efficacy are enhanced through exposure of the targeted cells to X-ray radiation. Administration of a prodrug regardless of administration route to the targeted cells is effective in combination with X-ray radiation therapy to kill or inhibit function of the targeted cells.Type: GrantFiled: February 20, 2012Date of Patent: September 25, 2018Assignees: SOUTHERN RESEARCH INSTITUTE, THE UAB RESEARCH FOUNDATIONInventors: William B. Parker, Eric J. Sorscher
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Patent number: 10039780Abstract: The present invention relates to high purity cangrelor, pharmaceutical formulations comprising high purity cangrelor as an active ingredient, methods for preparing such compounds and formulations, and methods for using the pharmaceutical formulations in the inhibition of platelet activation and aggregation.Type: GrantFiled: July 7, 2017Date of Patent: August 7, 2018Assignee: Chiesi Farmaceutici S.p.A.Inventors: Panna Dutta, Adel Rafai Far, Min Ding, Rajeshwar Motheram
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Patent number: 10028941Abstract: A pharmaceutical dosage system comprising (a) an effective amount of one or more of Doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof; (b) an effective amount of one or more of (i) Pyridoxine, (ii) an analog thereof, (iii) a derivative thereof, (iv) a prodrug thereof, (v) a metabolite thereof and (vi) a salt of any of (i)-(v); and (c) an effective amount of one or more compounds of formula (I) wherein R is H, PO3 or. The system exhibits an improved pharmacokinetic profile relative to the current Diclectin®/Diclegis® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting of pregnancy (NVP).Type: GrantFiled: March 13, 2014Date of Patent: July 24, 2018Assignee: DUCHESNAY INC.Inventors: Manon Vranderick, Jean-Luc St-Onge, Michele Gallo, Éric Gervais
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Patent number: 9988416Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions for treatment of viral infections, especially HRV.Type: GrantFiled: March 21, 2017Date of Patent: June 5, 2018Assignee: Novartis AGInventors: Martijn Fenaux, Oliver Saunders, Fumiaki Yokokawa, Weidong Zhong
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Patent number: 9872875Abstract: A method for treating viral infection includes administering to a subject in need thereof a composition containing P2X receptor antagonists. The methods may achieve preventive or therapeutic effect on hand foot and mouth disease by inhibiting viruses. The P2X receptor antagonists can inhibit infection by a positive-sense single-stranded RNA picornavirus. The virus may be an enterovirus or a Coxsackie virus, such as human enterovirus 71. The P2X receptor antagonist may be PPADS, iso-PPADS, PPNDS, Suramin, NF023, TNP-ATP, NF279, NF157, Evans Blue, an analog thereof, a derivative thereof, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 11, 2013Date of Patent: January 23, 2018Assignee: Honz Pharmaceutical Co., Ltd.Inventors: Altmeyer Ralf, Peijun Ren
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Patent number: 9700575Abstract: The present invention relates to high purity cangrelor, pharmaceutical formulations comprising high purity cangrelor as an active ingredient, methods for preparing such compounds and formulations, and methods for using the pharmaceutical formulations in the inhibition of platelet activation and aggregation.Type: GrantFiled: June 21, 2016Date of Patent: July 11, 2017Assignee: Chiesi Farmaceutici, S.P.A.Inventors: Panna Dutta, Adel Rafai Far, Min Ding, Rajeshwar Motheram
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Patent number: 9644039Abstract: Compositions and methods of making a modified polyhydroxylated polymer comprising a polyhydroxylated polymer having reversibly modified hydroxyl groups, whereby the hydroxyl groups are modified by an acid-catalyzed reaction between a polydroxylated polymer and a reagent such as acetals, aldehydes, vinyl ethers and ketones such that the modified polyhydroxylated polymers become insoluble in water but freely soluble in common organic solvents allowing for the facile preparation of acid-sensitive materials. Materials made from these polymers can be made to degrade in a pH-dependent manner. Both hydrophobic and hydrophilic cargoes were successfully loaded into particles made from the present polymers using single and double emulsion techniques, respectively. Due to its ease of preparation, processability, pH-sensitivity, and biocompatibility, of the present modified polyhydroxylated polymers should find use in numerous drug delivery applications.Type: GrantFiled: January 10, 2011Date of Patent: May 9, 2017Assignee: The Regents of the University of CaliforniaInventors: Jean M. J. Frechet, Eric M. Bachelder, Tristan T. Beaudette, Kyle E. Broaders