Ascorbic Acid Or Derivative (e.g., Vitamin C, Etc.) Patents (Class 514/474)
-
Patent number: 12220414Abstract: The present disclosure relates to methods, uses, pharmaceutical compositions comprising an sGC stimulator or a pharmaceutically acceptable salt thereof, alone or in combination with one or more additional therapeutic agents, for the treatment of a mitochondrial disorder.Type: GrantFiled: July 11, 2019Date of Patent: February 11, 2025Assignee: Tisento Therapeutics Inc.Inventor: John R. Hadcock
-
Patent number: 12223536Abstract: A method of providing customized cosmetic service according to an embodiment of the disclosure includes obtaining skin measurement information and skin input information of a user by using a user terminal, generating skin diagnosis information on a skin condition of the user based on the skin input information and the skin measurement information, generating recipe data for manufacturing customized cosmetics based on the skin diagnosis information, and manufacturing, by a customized cosmetic manufacturing apparatus, customized cosmetics based on the recipe data.Type: GrantFiled: October 8, 2021Date of Patent: February 11, 2025Assignee: LILLYCOVER CO., LTD.Inventor: Sun Hee An
-
Patent number: 12171833Abstract: This invention provides compositions for controlled localized depositing of one or more drugs within a subject. More particularly, described herein are compositions comprising a) a polyethylene glycol (PEG) composition having a first low molecular weight PEG (Mw between 200-500 Da) and a second low molecular weight PEG (Mw between 500-2000 Da) and b) a mucoadhesive in polymer. Alternatively, composition may comprise a) a polyethylene glycol (PEG) composition having a first low molecular weight PEG (Mw between 200-500 Da) and a second low molecular weight PEG (Mw between 500-2000 Da), b) a water insoluble polymer and c) a mucoadhesive polymer. Furthermore, the composition may further comprise one or more drugs. Also provided are methods of manufacturing and administering the compositions described herein, which are used as biodegradable, injectable mucoadhesive low-viscosity pastes.Type: GrantFiled: February 6, 2021Date of Patent: December 24, 2024Assignee: The University of British ColumbiaInventors: Veronika Schmitt, John K. Jackson, Martin E. Gleave, Claudia Kesch
-
Patent number: 12128091Abstract: A food supplement is disclosed that comprises an extracellular matrix composition of hydrolyzed collagen, hyaluronic acid and glucosamine, ascorbic acid and, optionally, a cannabinoid composition. The food supplement can be given to pet animals for the relief of or prophylaxis of degenerative joint diseases, such as arthritis.Type: GrantFiled: October 20, 2021Date of Patent: October 29, 2024Assignee: PAW POWER, INC.Inventor: Anja Skodda
-
Patent number: 12115258Abstract: The present invention refers to a particulate pharmaceutical or nutraceutical excipient, a process for the preparation of the particulate pharmaceutical or nutraceutical excipient, a pharmaceutical or nutraceutical composition comprising the particulate pharmaceutical or nutraceutical excipient as well as a process for manufacturing a pharmaceutical or nutraceutical composition.Type: GrantFiled: September 17, 2019Date of Patent: October 15, 2024Assignee: OMYA INTERNATIONAL AGInventors: Laura De Miguel, Stefan Lander
-
Patent number: 12103911Abstract: Provided is a method for producing a composition containing gallic acid, the composition having a low content rate of protocatechuic acid using a microbial culture solution. A method for producing a composition containing gallic acid, the method comprising a step (A) of performing cooling crystallization using an aqueous solution (a) containing gallic acid and protocatechuic acid at 0.9° C./min or less.Type: GrantFiled: July 1, 2020Date of Patent: October 1, 2024Assignee: KAO CORPORATIONInventors: Ryo Obunai, Yutaka Irie, Sawa Miyake
-
Patent number: 12097246Abstract: The invention is directed to a method of treating a spinal cord injury, a neurodegenerative disease or a neuronal injury in an individual in need thereof comprising administering an effective amount of superoxide dismutase (SOD) and catalase to the individual, wherein the superoxide dismutase and the catalase are encapsulated in one or more nanoparticles that release the SOD and catalase upon administration. Another aspect of the invention is directed to compositions comprising superoxide dismutase (SOD) and catalase encapsulated in one or more nanoparticles.Type: GrantFiled: June 22, 2022Date of Patent: September 24, 2024Assignee: The Cleveland Clinic FoundationInventors: Vinod Labhasetwar, Hayder H. Jaffer
-
Patent number: 12083179Abstract: The invention provides a colon cleansing solution comprising: a) 300 to 800 mmol per litre ascorbate anion provided by a mixture of: (i) ascorbic acid and (ii) one or more salts of ascorbic acid the components (i) and (ii) being present in a molar ratio of from 1:4.5 to 1:7.0; and b) 10 to 200 g per litre polyethylene glycol. The invention also provides methods and kits associated with, or making use of the solutions, and compositions for the preparation of the solutions.Type: GrantFiled: July 23, 2021Date of Patent: September 10, 2024Assignee: NORGINE BVInventors: Lucy Clayton, Alasdair Cockett, Mark Christodoulou, Ian Davidson, Lynn Farrag, Marc Halphen, Leighton Jones, Vanik Petrossian, Peter Stein, David Tisi, Alex Ungar, Jeffrey Worthington
-
Patent number: 12076358Abstract: The composition comprises a preparation of Desmodium and a trivalent chromium salt. The composition preferably comprises Desmodium adscendens or Desmodium gangeticum and chromium chloride, chromium nicotinate or chromium picolinate. It is formulated alone or with other active substances, excipients or additives, for oral administration as a medicinal product, phytomedicinal product, medical device, dietary supplement or admixture to a food product. It is intended for use in the prevention or treatment of a retinal degenerative disease such as age-related maculopathy (ARM) and dry or wet age-related macular degeneration (ARMD).Type: GrantFiled: March 23, 2020Date of Patent: September 3, 2024Assignee: LABORATOIRES THEAInventors: Sophie Hvostoff, Rima Yazbeck
-
Patent number: 12036303Abstract: A multi-action skin-lightening cosmetic composition is provided. The cosmetic composition comprises ascorbic acid delivered in a stable form in a high concentration and, optionally, other complementary active ingredients.Type: GrantFiled: June 18, 2019Date of Patent: July 16, 2024Assignee: NATURA COSMÉTICOS S.A.Inventors: Fabiana Paes, Camila Pereira Santos, Priscila Carollo Moncayo, Mayara Baradel
-
Patent number: 12029726Abstract: A micronutrient composition is highly effective in treating joint related inflammation and reducing ECM damaging enzymes in joints. The micronutrient composition comprises of Vitamin C, Vitamin E (D-alpha tocopherol), Vitamin B6, Vitamin D3, Folic acid, L-proline, L-lysine, Copper, Betaine HCl, Chondroitin sulfate, N-acetyl-glucosamine, Pycnogenol, SAMe, Cat's claw, Boswellia serrata, Stinging nettle and Glutamine. The micronutrient composition was most effective in supporting critical cellular mechanisms important for healthy joints-increased production and deposition of important ECM components by synovial cells and chondrocytes under pro-inflammatory conditions (presence of LPS). The micronutrient composition also decreased pro-inflammatory IL-6 and decreased secretion of MMP13, the ECM damaging enzyme in joints.Type: GrantFiled: July 6, 2023Date of Patent: July 9, 2024Inventor: Matthias W Rath
-
Patent number: 11957775Abstract: Personal care compositions for improving the appearance and/or health of skin are provided herein. In accordance with an aspect, provided is a personal care formulation comprising an alpha hydroxy acid; a beta hydroxy acid; and polyhydroxy acid comprising gluconodeltalactone. According to another aspect, a personal care formulation is provided that comprises an alpha hydroxy acid; a beta hydroxy acid; and polyhydroxy acid, wherein the personal care formulation has a weight ratio of alpha hydroxy acid to polyhydroxy acid is about 5:1 to about 1:4, and wherein the personal care formulation has a weight ratio of beta hydroxy acid to polyhydroxy acid is about 1:1 to about 1:11.Type: GrantFiled: May 13, 2022Date of Patent: April 16, 2024Assignee: Colgate-Palmolive CompanyInventors: Melissa Moy, Ewelina Lesniak, Kristina Fabijanic
-
Patent number: 11938171Abstract: Presented herein are compositions that can be administered to a subject having damaged tissue, for example a wound. The compositions are often administered in combination with administration of energy (e.g., laser energy, light from a light emitting diode, radiofrequency (RF) energy, audio frequency energy, etc.) from an energy generating device and/or system to the affected site. The compositions, systems, devices, and methods herein were found to induce wound healing and tissue regeneration.Type: GrantFiled: December 8, 2021Date of Patent: March 26, 2024Assignee: THE BIOREGENTECH INSTITUTE, INC.Inventor: Margaret V. Kalmeta
-
Patent number: 11896581Abstract: The present disclosure provides compositions and methods for providing a health benefit to an animal utilizing ferulic acid and histidine. For example, a composition can contain ferulic acid and histidine in therapeutically effective amounts for providing the health benefit to the animal.Type: GrantFiled: August 10, 2021Date of Patent: February 13, 2024Assignee: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.Inventors: Francois-Pierre Martin, Christian Darimont-Nicolau, Andreas Rytz
-
Patent number: 11877998Abstract: One or more techniques and/or systems are disclosed for a method of administering a composition of an orally administered agent devised to provide desirable nutrients and other supplements to the body, which may help mitigate degradation of the skin, and may help promote the health of the skin, and/or treatment of skin conditions. The composition can comprise ingredients of a selected type, amount, and source, which, in this particular arrangement, may promote healthy skin and improve skin condition in a person. A composition that promotes healthy skin can comprise vitamin A; vitamin C; vitamin E; vitamin B6; zinc; rose hip extract; copper; and vitamin B3.Type: GrantFiled: September 9, 2019Date of Patent: January 23, 2024Assignee: H &H Science, LLCInventors: Helen M. Torok, Heather L Funk
-
Patent number: 11857525Abstract: A specialized immunonutrition supplement can be administered to a surgical patient to reduce post-operative complications by restraining the expansion of myeloid-derived suppressor cells. The supplement includes one or more of L-arginine, omega-3 fatty acids, vitamin A, and dietary nucleotides, preferably all four of these compounds. The supplement is administered to the patient at least once per day for a time period extending from a pre-operative day that is three to seven days prior to a bladder surgery of the patient to a post-operative day that is three to seven days after the bladder surgery. The supplement can be administered to treat or prevent post-operative paralytic ileus in a bladder cancer patient; treat or prevent surgery-induced, inflammation-induced or cancer-induced cachexia; reduce the incidence of chronic infections resulting from expansion of myeloid-derived suppressor cells in a patient; and/or reduce mRNA expression of pro-inflammatory cytokines in a patient.Type: GrantFiled: February 15, 2016Date of Patent: January 2, 2024Assignee: Societe des Produits Nestle S.A.Inventors: Jill Hamilton-Reeves, Jeffrey M. Holzbeierlein, Thomas Yankee
-
Patent number: 11839603Abstract: An object of the present invention is to provide an ascorbic acid formulation that can be prepared by a simple method, and that has a reduced unpleasant taste and coloration. The inventors found that an ascorbic acid formulation that is in the form of a water-in-oil type emulsion, that comprises an aqueous phase with a pH of 4 or more and an average particle size of 300 nm or less, and that has a mass ratio of water/ascorbic acid of 0.05 to 0.40 has a reduced unpleasant taste and coloration; and accomplished the present invention. Additionally, the present invention can be prepared by a simple method.Type: GrantFiled: January 28, 2019Date of Patent: December 12, 2023Assignee: FUJI OIL HOLDINGS INC.Inventors: Arata Hashimoto, Masaharu Kato
-
Patent number: 11835503Abstract: The present invention provides markers and methods for determining whether a subject, particularly a human subject, has or is at risk of developing, a disease such as cardiovascular disease, diabetes mellitus, insulin resistance, metabolic syndrome, NAFLD (Nonalcoholic Fatty Liver Disease) or NASH (Nonalcoholic Steatohepatitis) (e.g., within the ensuing year, two years, and/or three years). The present application also relates to the use of such markers and methods for monitoring the status of such diseases in a subject or the effects of therapeutic agents on subjects with such diseases.Type: GrantFiled: April 19, 2021Date of Patent: December 5, 2023Assignee: The Cleveland Clinic FoundationInventors: Stanley L. Hazen, Zeneng Wang, Bruce S. Levison
-
Patent number: 11833139Abstract: The invention provides systems and methods for increased clinical efficacy of rifabutin against A. baumannii. The invention takes advantage of the discovery of a ferric-coprogen (FhuE) receptor that is responsible for the uptake of rifabutin into A. baumannii cells. Methods preferably include obtaining a sample from a patient suspected of having an infection; performing a test on the sample to identify an infection of A. baumannii in the patient; and providing a formulation of rifabutin for treating the patient that, when administered to the patient, maximizes a resultant AUC and/or Cmax. The method may include administering the formulation of rifabutin to the patient. Preferably the formulation is delivered to the patient, e.g., by intravenous injection and results in a Cmax is that greater than about 2 mg/L and optionally less than about 50 mg/L.Type: GrantFiled: June 6, 2022Date of Patent: December 5, 2023Assignee: BIOVERSYS AGInventors: Glenn E. Dale, Sergio Lociuro, Christian Kemmer, Vincent Trebosc, Marc Gitzinger
-
Patent number: 11826346Abstract: The present disclosure relates to compositions and methods of increasing magnesium bioavailability and absorption.Type: GrantFiled: October 28, 2021Date of Patent: November 28, 2023Assignee: Balchem CorporationInventors: Shane Christopher Morgan, Ren A. Gonzalez
-
Patent number: 11806320Abstract: Storage stable aqueous ready-to-administer formulations comprising isoproterenol are presented with desirable stability characteristics. In preferred aspects, formulations are terminally sterilized and packaged in a suitable format, such as a polymeric bag with metalized overwrap and include a non-contact oxygen scavenger.Type: GrantFiled: February 18, 2021Date of Patent: November 7, 2023Assignee: ENDO VENTURES LIMITEDInventors: Ronald Domalaon, Jinjiang Li, Tushar Hingorani, Kumaresh Soppimath
-
Patent number: 11752123Abstract: An anxiolytic composition includes a synergistic combination of one or more of an L-theanine, an s-adenosylmethionine (SAMe), and optionally an extract of Magnolia, an extract of Phellodendron, and a whey protein.Type: GrantFiled: January 25, 2021Date of Patent: September 12, 2023Assignee: NUTRAMAX LABORATORIES, INC.Inventors: Todd Henderson, David Griffin, David Bledsoe
-
Patent number: 11737988Abstract: Disclosed is a method of manufacturing a cardiovascular fixed-dose combination pharmaceutical dosage form that includes an anti-hypertensive active agent, a cholesterol-lowering active agent, and optionally, an enteric-coated aspirin or platelet inhibitor. The fixed-dose combination is prepared with at least two granulation solutions that are free of citric acid and enhance the aqueous solubility of the cholesterol-lowering agent in fixed-dose combination. The active agents in the resulting dosage form, which is also free of citric acid, have the same strength and release profiles as the same active agents prepared as a single formulation.Type: GrantFiled: April 17, 2019Date of Patent: August 29, 2023Assignee: CardioPharma, Inc.Inventors: Roy A. Stimits, Daniel Tyree Gregory, Jr., Wayne L. Whittingham, Stephan Dale Glenn, David P. Hause
-
Patent number: 11730696Abstract: The present invention relates to the use of scaffolds to enhance the viability of cells implanted in the integumentary system such that the cell may release an agent. The scaffold is capable of protecting the cell, as well as allowing for adequate nutrient delivery at the implant site through vascularisation in and around the scaffold.Type: GrantFiled: October 18, 2017Date of Patent: August 22, 2023Assignee: AUSTRALIAN FOUNDATION FOR DIABETES RESEARCHInventors: Bernard Tuch, Tim Dargaville, Auvro Mridha, Paul Dalton, Vijayaganapathy Vaithilingam
-
Patent number: 11731928Abstract: Provided are co-crystals of a sodium benzoate compound and a co-former compound of Formula (I) Also provided herein are methods of preparing the co-crystals and uses thereof in treating and/or reducing the risk for a neuropsychiatric disorder (e.g., schizophrenia, psychotic disorders, depressive disorders, or Alzheimer's disease) or a glucose or lipid metabolic disorder (e.g., obesity, diabetes, hypercholesterolemia, hypertension, or hyperlipidemia).Type: GrantFiled: May 3, 2021Date of Patent: August 22, 2023Assignee: SyneuRx International (Taiwan) Corp.Inventors: Guochuan Emil Tsai, Ching-Cheng Wang, Tien-Lan Hsieh, Yuan-Chun Lo
-
Patent number: 11717554Abstract: The invention provides methods for preventing or treating hangover symptom(s) associated with consumption of alcoholic beverage(s) in a subject comprising administering an aldehyde sequestering agent so as to reduce or counter blood aldehyde buildup in the subject, thereby preventing or treating hangover symptom(s) associated with consumption of alcoholic beverage(s) in the subject.Type: GrantFiled: November 2, 2020Date of Patent: August 8, 2023Assignee: MAX R&D LLCInventor: Herbert Nagasawa
-
Patent number: 11707484Abstract: The invention relates to a food supplement containing minerals and/or vitamins, a humectant and, for example, essential oils. The food supplement is formulated as an oral spray. In particular, the invention relates to a concentrated food supplement in the form of an oral spray, containing a combination of magnesium ions, panthenol (vitamin B5), caffeine, menthol aroma and/or peppermint aroma, and a humectant. The food supplement is particularly suited for use in sport and in stressful situations.Type: GrantFiled: January 14, 2019Date of Patent: July 25, 2023Assignee: URSAPHARM ARZNEIMITTEL GMBHInventors: Ute Steinfeld, Dominik Holzer
-
Patent number: 11684555Abstract: Oral compositions and methods of use thereof are provided herein. The oral compositions comprise a first component comprising at least one Eh-raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound, an anti-microbial agent and a pharmaceutically acceptable carrier.Type: GrantFiled: May 27, 2020Date of Patent: June 27, 2023Assignee: The Research Foundation For The State University Of New YorkInventors: Marvin Cohen, Susanne Cohen, Robert Flynn
-
Patent number: 11660294Abstract: Disclosed are anti-avian pathogenic E. coli (APEC) agents as well as methods of using thereof.Type: GrantFiled: July 15, 2019Date of Patent: May 30, 2023Assignee: OHIO STATE INNOVATION FOUNDATIONInventors: Gireesh Rajashekara, Dipak Kathayat, Yosra A. Helmy, Loïc Deblais
-
Patent number: 11629169Abstract: The present invention relates to use of peptides as a therapeutic agent, wherein it has been confirmed that the peptides of the present invention significantly inhibit the activity of T cells and the differentiation of T helper 17 cells (Th17 cells), which are associated with autoimmune disease, and have remarkable effects of treating and improving arthritis in an animal model of arthritis. Therefore, the peptides may be used as an active ingredient in therapeutic agents for various autoimmune diseases such as bone disease, inflammatory disease or rheumatoid arthritis.Type: GrantFiled: September 14, 2018Date of Patent: April 18, 2023Assignee: KINE SCIENCES CO., LTD.Inventors: Dae Ho Cho, Kyung Eun Kim, Myun Soo Kim, Sun Young Park, Hee Young Jung
-
Patent number: 11617708Abstract: The invention concerns a composition, advantageously cosmetic, comprising: at least one basic amino acid selected from the group constituted by arginine, lysine, histidine, ornithine, hydroxyproline and one of their salts; and at least one glycosylceramide, and its use for preventing and/or treating atopic dermatitis.Type: GrantFiled: December 21, 2021Date of Patent: April 4, 2023Assignees: NAOS INSTITUTE OF LIFE SCIENCEInventor: Jean-Noël Thorel
-
Patent number: 11559498Abstract: A method of treating coronavirus infection, post-acute sequelae of coronavirus infection, and viral mediated respiratory distress in a subject in need thereof includes administering to the subject a therapeutically effective amount of agent that promotes, increases, and/or induces hemoglobin nitrosylation within red blood cells (RBCs) and GSNO levels in the lung or airways of the subject.Type: GrantFiled: December 27, 2021Date of Patent: January 24, 2023Assignee: UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTERInventor: Jonathan S. Stamler
-
Patent number: 11547645Abstract: An organic UVA filter-stabilized antioxidant system demonstrates stabilization after UV exposure as compared with controls lacking the UVA filter stabilizer. The organic UVA filter-stabilized antioxidant system provides a cosmetic composition that confers preserved and sustained antioxidant efficacy to keratinous tissue. The antioxidant system includes a combination of at least one hydroxycinnamate derivative, and an organic, water-soluble UVA filter in a water-based carrier.Type: GrantFiled: January 5, 2021Date of Patent: January 10, 2023Assignee: L'OREALInventors: Nicholas David Stebbins, Susan Halpern Chirch
-
Patent number: 11542078Abstract: The invention concerns a device and a method for the preparation of a liquid composition for oral administration of a liquid composition formed by a liquid component and a component in powder form, for the treatment of persons affected by metabolic disorders, in particular appropriately selecting the compounds to be added to the drink according to the specific metabolic disorder.Type: GrantFiled: October 30, 2018Date of Patent: January 3, 2023Inventors: Virna Lucia Cerne, Ombretta Polenghi, Fabio Barban
-
Patent number: 11452710Abstract: The micronutrient and plant extract composition comprises of a vitamin C, vitamin A (?-carotene), vitamin E, vitamin D3, vitamin K2, folic acid, calcium, magnesium, boron, horsetail extract, zinc, potassium, copper, methylsulfonylmethane (MSM) and stinging nettle extract and in combination it is used for treating, and reversing bone demineralization. The micronutrient and plant extract composition when administered to mammal with or without bone disease strengthens and helps in bone mineralization process. The composition can be used as a preventive dose for bone demineralization in human.Type: GrantFiled: February 17, 2022Date of Patent: September 27, 2022Inventor: Matthias W Rath
-
Patent number: 11433017Abstract: A process for the production of a solid cosmetic preparation is described wherein a wax phase comprising at least one wax, at least one oil, and if applicable, oil-soluble ingredients and solvents are melted, the molten wax phase is mixed with an aqueous phase comprising at least one water-soluble or water-soluble water-dispersible film former and with a w/o emulsifying system until an emulsion is formed, and the resulting emulsion is allowed to cool to form a wax matrix with aqueous phase droplets embedded therein, and the products made therefrom and their use.Type: GrantFiled: December 28, 2017Date of Patent: September 6, 2022Inventors: Ingolf Kahle, Simona Lebok, Christian Sprogar
-
Patent number: 11357717Abstract: A device and protective composition is described that is used in the context of first aid for skin contact with acids, bases, oxidizing agents, formaldehyde and fluorides serving to neutralize and inactivate the chemicals. The device comprises a two-chamber applicator that contains a first preparation in a first chamber, such as an antioxidant, and a second preparation in a second chamber, such as a solution that contains a buffer and a calcium salt. The two preparations are mixed just before application and are applied to the affected areas by the device.Type: GrantFiled: December 18, 2019Date of Patent: June 14, 2022Assignee: Field Forensics, Inc.Inventor: Katharina Holtkamp
-
Patent number: 11337958Abstract: Compositions and methods are disclosed for treating anxiety or stress in an animal, for reducing elevated levels of 4-EPS in an animal with elevated 4-EPS levels, for preventing elevated levels of 4-EPS in an animal and for promoting growth of beneficial microbes in an animal's microbiome and inhibiting growth of non-beneficial microbes. The methods comprise administering to the animal an effective amount of soy protein and vitamin C. Compositions are disclosed which comprise amounts of soy protein and vitamin C effective for use in the methods.Type: GrantFiled: December 19, 2019Date of Patent: May 24, 2022Assignee: Hills Pet Nutrition, Inc.Inventors: Eden Ephraim, Dennis Jewell
-
Patent number: 10835468Abstract: The invention relates to a cosmetic composition comprising one or more pyridinedicarboxylic acid derivatives of general formula (I) or a salt thereof and one or more antioxidants chosen from flavone heterosides, polyhydroxylated stilbenes, pyrimidinecarboxylic acid derivatives and ascorbic acid esters.Type: GrantFiled: December 21, 2015Date of Patent: November 17, 2020Assignee: L'OREALInventor: Francois Michelet
-
Patent number: 10646512Abstract: The invention provides a colon cleansing solution comprising: a) 300 to 2000 mmol per litre ascorbate anion provided by ascorbic acid, one or more salts of ascorbic acid, or a mixture thereof; and b) 10 to 200 g per litre polyethylene glycol. The invention also provides methods and kits associated with, or making use of the solutions. The invention also provides a method of cleansing the colon of a subject comprising: —administering to the subject an effect amount of a first cleansing solution; and then after a time interval—administering to the subject an effective amount of a second cleansing solution, wherein the two cleansing solutions are as described in the specification.Type: GrantFiled: January 16, 2017Date of Patent: May 12, 2020Assignee: NORGINE BVInventors: Marc Halphen, Hans-Jurgen Gruss, Ian Cox, Alasdair Cockett, Peter Stein, Alex Ungar
-
Patent number: 10638959Abstract: Example embodiments of the present invention include various compositions that include a pH modifier composition and/or a buffering capacity modifier composition. In some examples, the pH modifier compositions include a dose of pH modifier to raise the pH in a patient's mouth from about 1 to about 2 pH levels. The compositions are then incorporated into various confections for oral ingestion or application that allow a patient to easily use the composition with the pH and/or buffering capacity modifiers. For example, compositions with the pH and/or buffering capacity modifiers can be incorporated within chewing gum, tablets, lozenges, breath strips, hard candy, oral sprays, and other confections. Another embodiment of the invention includes a testing device to test the pH and buffering capacity within a patient's mouth.Type: GrantFiled: September 19, 2017Date of Patent: May 5, 2020Assignee: CAO Group, LLCInventors: Steven D Jensen, Densen Cao
-
Patent number: 10626079Abstract: Disclosed is a method for preparing high-quality anhydrous choline halide single crystal and its derivatives. The single crystal product has good stability of light and heat. It also has the advantages of moisture resistant, deliquescent resistance and is not easy to agglomerate. The method is simple in operation. The solvent used in the process is difficult to volatilize and can be recycled.Type: GrantFiled: April 28, 2017Date of Patent: April 21, 2020Assignee: HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Erhong Duan, Shaohan Lian, Zidan Chen, Hongwei Ren, Hua Sun, Jianrui Niu
-
Agent exhibiting anti-stress, anxiolytic and anti-depression activity, and composition based thereon
Patent number: 10456373Abstract: The agent with antistress, anxiolytic and antidepressant activity and a composition based on it. The invention relates to the field of pharmaceutics, particularly to chemical compounds based on lithium salts, namely to substances with antistress, anxiolytic and antidepressant activity and can be used in medicine, veterinary medicine, and the pharmaceutical industry. The invention discovers the possibility of using lithium ascorbate as an agent with antistress, anxiolytic and antidepressant activity. The claimed composition with antistress, anxiolytic and antidepressant activity, including a lithium salt, contains pyridoxine hydrochloride, thiamine mononitrate and lithium ascorbate as a lithium salt. The use of lithium ascorbate as an agent with antistress, anxiolytic and antidepressant action and the composition based on it, enables to expand the assortment of the agents for indicated administration. At the same time, the claimed agents have low toxicity and high efficacy.Type: GrantFiled: April 11, 2018Date of Patent: October 29, 2019Assignee: OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYU “NORMOFARM”Inventors: Viacheslav Valerievich Rastashanskiy, Konstantin Sergeevich Ostrenko -
Patent number: 10322078Abstract: The present invention provides a cosmetic composition containing (A) 3-O-alkyl-L-ascorbic acid wherein the alkyl group has 8-12 carbon atoms or a salt thereof, (B) one or more kinds of nonionic surfactants selected from the group consisting of polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl ether and polyoxyethylene alkenyl ether, and having an HLB value of 12.5-17, and (C) one or more kinds of oil agents selected from the group consisting of amino acid ester, dimer acid ester, hydroxy acid ester, alkyl glyceryl ether and alkenyl glyceryl ether, which is superior in solubilization stability, preservation stability and sense of use, and free of time-dependent development of an odor which poses a problem when in use.Type: GrantFiled: December 9, 2016Date of Patent: June 18, 2019Assignee: AJINOMOTO CO., INC.Inventor: Mandai Yamada
-
Patent number: 10219997Abstract: The present invention provides a novel radiosensitizer or anti-cancer chemotherapy sensitizer. In particular, the invention provides a radiosensitizer or anti-cancer chemotherapy sensitizer that can relieve the irritation of an affected area caused by hydrogen peroxide, is safe when injected into a human body, and can delay or reduce the degradation of hydrogen peroxide and thereby can efficiently exert a radiation sensitizing effect and an anti-cancer chemotherapy sensitizing effect. The radiosensitizer or anti-cancer chemotherapy sensitizer comprises a combination of (a) hydrogen peroxide and (b) hyaluronic acid or salt thereof.Type: GrantFiled: September 21, 2007Date of Patent: March 5, 2019Assignee: KOCHI UNIVERSITYInventor: Yasuhiro Ogawa
-
Patent number: 10188607Abstract: The object of the present invention is a pharmaceutical formulation of racecadotril characterized by high bioavailability. In particular, the present invention relates to a method of dry granulating racecadotril in the presence of a hydrophilic excipient and a disintegrant, preferably with a low moisture content; said method being carried out by means of a tablet machine or alternately a roller compacting machine, carrying out the compaction step with a compaction strength of less than 30 kN and equal to or greater than 4 kN, and the step of grinding the slugs and screening so as to obtain a granulate in which not more than 50% by weight of the product has a particle size of less than 90 micron.Type: GrantFiled: December 23, 2015Date of Patent: January 29, 2019Assignee: Rivopharm SAInventors: Piero Poli, Alessandro Fiorino, Tommaso Roberto Piazzolla
-
Patent number: 9757320Abstract: Provided herein is an oral care composition comprising an orally-acceptable aqueous vehicle and an antimicrobial ingredient, wherein the antimicrobial ingredient comprises a zinc ascorbylphosphate and methods for treating or preventing a disease or disorder of the oral cavity using the oral care compositions disclosed herein.Type: GrantFiled: December 19, 2012Date of Patent: September 12, 2017Assignee: Colgate-Palmolive CompanyInventors: Zhigang Hao, Ying Yang, Zhiqiang Liu, Xu Guofeng, Paul Joseph Vincenti
-
Patent number: 9744152Abstract: Provided herein is a pharmaceutical composition comprising vitamin C and chromium-free vitamin K, and optionally one or more pharmaceutically acceptable excipient(s). Also provided herein is a chromium-free pharmaceutical composition comprising vitamin C and vitamin K, and optionally one or more pharmaceutically acceptable excipient(s). Further provided herein is a method of treating, preventing, or managing an NF?B-mediated condition, disorder, or disease, comprising administering to the subject a therapeutically effective amount of vitamin C and chromium-free vitamin K. Provided herein are methods for treating, preventing, or ameliorating one or more symptoms of a polycystic disease in a subject, comprising administering to the subject a therapeutically effective amount of vitamins C and K.Type: GrantFiled: June 29, 2016Date of Patent: August 29, 2017Assignee: IC-MedTech CorporationInventors: Thomas M. Miller, Tetyana V. Masyuk, Nicholas F. Larusso
-
Patent number: 9675067Abstract: Embodiments herein relate to animal feed preservatives including byproducts containing levulinic acid and methods of making and using the same. In an embodiment, a method of making an animal feed preservative is included. The method can include obtaining an acidic byproduct of a manufacturing process. The acidic byproduct can include at least about 1% by weight levulinic acid or a salt thereof. The method can further include mixing the acidic byproduct with a base to form the animal feed preservative. The animal feed preservative can include at least about 5 wt. % of the acid byproduct. In various embodiments, a method of reducing the amount of mycotoxins formed in an animal feed product during storage is included. In various embodiments, an animal feed preservative or supplement is included. Other embodiments are also included herein.Type: GrantFiled: September 2, 2015Date of Patent: June 13, 2017Assignee: Hawkins, Inc.Inventors: Theodore R. Stern, Stephen G. Campano, Gary Carl Larson
-
Patent number: 9669053Abstract: Methods for treating cancers, tumors, and neoplasms using a composition comprising one or more generally regarded as safe (GRAS) compounds selected from the group of components consisting of vitamins, selenium, fatty acids, fatty acid salts, and fatty acid esters, and mixtures of two or more said components, either as a stand-alone treatment or in combination with one or more anti-cancer drugs or devices or other anti-neoplastic agents, treatments, or devices are provided. In some instances, concomitant hyperthermia therapy is employed. Also provided are compositions and kits containing the compositions, for implement various aspects of the invention.Type: GrantFiled: July 25, 2011Date of Patent: June 6, 2017Assignee: ChemoTherapeutics, LLCInventors: Gary Keeling, Keith B. Hoffman