Ascorbic Acid Or Derivative (e.g., Vitamin C, Etc.) Patents (Class 514/474)
  • Patent number: 10219997
    Abstract: The present invention provides a novel radiosensitizer or anti-cancer chemotherapy sensitizer. In particular, the invention provides a radiosensitizer or anti-cancer chemotherapy sensitizer that can relieve the irritation of an affected area caused by hydrogen peroxide, is safe when injected into a human body, and can delay or reduce the degradation of hydrogen peroxide and thereby can efficiently exert a radiation sensitizing effect and an anti-cancer chemotherapy sensitizing effect. The radiosensitizer or anti-cancer chemotherapy sensitizer comprises a combination of (a) hydrogen peroxide and (b) hyaluronic acid or salt thereof.
    Type: Grant
    Filed: September 21, 2007
    Date of Patent: March 5, 2019
    Assignee: KOCHI UNIVERSITY
    Inventor: Yasuhiro Ogawa
  • Patent number: 10188607
    Abstract: The object of the present invention is a pharmaceutical formulation of racecadotril characterized by high bioavailability. In particular, the present invention relates to a method of dry granulating racecadotril in the presence of a hydrophilic excipient and a disintegrant, preferably with a low moisture content; said method being carried out by means of a tablet machine or alternately a roller compacting machine, carrying out the compaction step with a compaction strength of less than 30 kN and equal to or greater than 4 kN, and the step of grinding the slugs and screening so as to obtain a granulate in which not more than 50% by weight of the product has a particle size of less than 90 micron.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: January 29, 2019
    Assignee: Rivopharm SA
    Inventors: Piero Poli, Alessandro Fiorino, Tommaso Roberto Piazzolla
  • Patent number: 9757320
    Abstract: Provided herein is an oral care composition comprising an orally-acceptable aqueous vehicle and an antimicrobial ingredient, wherein the antimicrobial ingredient comprises a zinc ascorbylphosphate and methods for treating or preventing a disease or disorder of the oral cavity using the oral care compositions disclosed herein.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: September 12, 2017
    Assignee: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Ying Yang, Zhiqiang Liu, Xu Guofeng, Paul Joseph Vincenti
  • Patent number: 9744152
    Abstract: Provided herein is a pharmaceutical composition comprising vitamin C and chromium-free vitamin K, and optionally one or more pharmaceutically acceptable excipient(s). Also provided herein is a chromium-free pharmaceutical composition comprising vitamin C and vitamin K, and optionally one or more pharmaceutically acceptable excipient(s). Further provided herein is a method of treating, preventing, or managing an NF?B-mediated condition, disorder, or disease, comprising administering to the subject a therapeutically effective amount of vitamin C and chromium-free vitamin K. Provided herein are methods for treating, preventing, or ameliorating one or more symptoms of a polycystic disease in a subject, comprising administering to the subject a therapeutically effective amount of vitamins C and K.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: August 29, 2017
    Assignee: IC-MedTech Corporation
    Inventors: Thomas M. Miller, Tetyana V. Masyuk, Nicholas F. Larusso
  • Patent number: 9675067
    Abstract: Embodiments herein relate to animal feed preservatives including byproducts containing levulinic acid and methods of making and using the same. In an embodiment, a method of making an animal feed preservative is included. The method can include obtaining an acidic byproduct of a manufacturing process. The acidic byproduct can include at least about 1% by weight levulinic acid or a salt thereof. The method can further include mixing the acidic byproduct with a base to form the animal feed preservative. The animal feed preservative can include at least about 5 wt. % of the acid byproduct. In various embodiments, a method of reducing the amount of mycotoxins formed in an animal feed product during storage is included. In various embodiments, an animal feed preservative or supplement is included. Other embodiments are also included herein.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: June 13, 2017
    Assignee: Hawkins, Inc.
    Inventors: Theodore R. Stern, Stephen G. Campano, Gary Carl Larson
  • Patent number: 9669074
    Abstract: The present invention provides a formulation comprising a corticosteroid and an insulin analog. Also provided is a formulation comprising a corticosteroid, an insulin analog and at least one organic acid. Further provided are pharmaceutical compositions of the formulations described herein. The present invention provides methods for stimulating bone and/or cartilage growth, for stimulating hair growth and/or reducing hair loss, for stimulating growth of a tooth and/or periodontium and for treating tumors and cysts of the jaw by administering the formulations described herein.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: June 6, 2017
    Inventors: Juan Paz Garcia, Brenda Astrid Paz Michel
  • Patent number: 9669053
    Abstract: Methods for treating cancers, tumors, and neoplasms using a composition comprising one or more generally regarded as safe (GRAS) compounds selected from the group of components consisting of vitamins, selenium, fatty acids, fatty acid salts, and fatty acid esters, and mixtures of two or more said components, either as a stand-alone treatment or in combination with one or more anti-cancer drugs or devices or other anti-neoplastic agents, treatments, or devices are provided. In some instances, concomitant hyperthermia therapy is employed. Also provided are compositions and kits containing the compositions, for implement various aspects of the invention.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: June 6, 2017
    Assignee: ChemoTherapeutics, LLC
    Inventors: Gary Keeling, Keith B. Hoffman
  • Patent number: 9649288
    Abstract: An inhibitor of visceral fat loss is capable of suppressing body weight loss peculiarly found in Parkinson's disease patients. The inhibitor of visceral fat loss in Parkinson's disease patients of the present invention contains a lipid obtained by subjecting a medium-chain triglyceride that includes as a constitutive fatty acid at least one of a saturated fatty acid having 8 carbon atoms and a saturated fatty acid having 10 carbon atoms to a transesterification reaction with a vegetable oil. The lipid is preferably obtained by subjecting the medium-chain triglyceride to a transesterification reaction with the vegetable oil at a ratio of 10:90 to 20:80.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: May 16, 2017
    Assignee: THE NISSHIN OILLIO GROUP, LTD.
    Inventors: Shin Terada, Sayuri Yamamoto
  • Patent number: 9642833
    Abstract: Provided herein is a method of treating, preventing, or managing osteolysis in a subject, comprising administering to the subject a therapeutically effective amount of vitamin C, or a pharmaceutically acceptable salt, solvate, or hydrate thereof, in combination with vitamin K, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof, or a pharmaceutically acceptable salt, solvate, or hydrate thereof.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: May 9, 2017
    Assignee: IC-MEDTECH CORPORATION
    Inventors: James M. Jamison, Thomas M. Miller, Deborah R. Neal, Mark William Kovacik, Michael John Askew, Richard Albert Mostardi
  • Patent number: 9636324
    Abstract: Disclosed is use of andrographolide derivative as shown by general formula 1 in manufacture of medicaments for anti-hepatitis C virus, and preventing and treating immunological liver damage caused by virus infection and different chemical liver damage.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: May 2, 2017
    Assignee: Zhengzhou University
    Inventors: Guifu Dai, Jing Zhao, Haiwei Xu, Huanfei Liu, Zhenwei Wu, Di Wu, Jian Wu, Hongmin Liu
  • Patent number: 9326969
    Abstract: The invention provides a colon cleansing solution comprising: a) 300 to 800 mmol per litre ascorbate anion provided by a mixture of: (i) ascorbic acid and (ii) one or more salts of ascorbic acid the components (i) and (ii) being present in a molar ratio of from 1:4.5 to 1:7.0; and b) 10 to 200 g per litre polyethylene glycol. The invention also provides methods and kits associated with, or making use of the solutions, and compositions for the preparation of the solutions.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: May 3, 2016
    Assignee: NORGINE BV
    Inventors: Lucy Clayton, Alasdair Cockett, Mark Christodoulou, Ian Davidson, Lynn Farrag, Marc Halphen, Leighton Jones, Vanik Petrossian, Peter Stein, David Tisi, Alex Ungar, Jeffrey Worthington
  • Patent number: 9301909
    Abstract: Disclosed are methods of mitigating the effects of exposure to oxidizing agents, chlorinating and/or brominating agents on biological and/or synthetic fibers, by treating the body and/or clothing fibers with an effective amount of a composition comprising compounds of formula A. Also disclosed are compositions comprising compounds of formula A, for use in treating biological and/or synthetic fibers to mitigate the effects of exposure to chlorinating and/or brominating agents.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: April 5, 2016
    Inventor: Andrew R. Chadeayne
  • Patent number: 9295630
    Abstract: A complex formed of at least one molecule of 5-(1,2-dihydroxy-ethyl)-3,4-dihydroxy-5H-furan-2-one or a derivative covalently bonded with at least one hydrocarbon radical with formula (A) as follows: wherein: •-m 1=1, 2, 3, 4, 5 or 6; •-m 2=0, 1, 2, 3, 4, 5 or 6; and represents the site of the bond with the molecule of 5-(1,2-dihydroxy-ethyl)-3,4-dihydroxy-5H-furan-2-one or derivative.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: March 29, 2016
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS SUD XI
    Inventors: Patrick Couvreur, Fatima Zouhiri, Ruxandra Gref, Didier Desmaele
  • Patent number: 9248082
    Abstract: An anti-aging composition containing: (a) at least one first active ingredient chosen from phloretin and its derivatives; (b) at least one second active ingredient chosen from cinnamic acid, resveratrol, retinol, ascorbic acid, tocopherol, and their derivatives; and (c) at least one non-aqueous organic solvent, with the proviso that if the composition contains ascorbic acid, water is present as a co-solvent.
    Type: Grant
    Filed: April 15, 2009
    Date of Patent: February 2, 2016
    Assignee: L'OREAL
    Inventors: Sheldon R. Pinnell, Jan Zielinski, Isabelle Hansenne
  • Patent number: 9138599
    Abstract: Disclosed are waving compositions for waving of keratinous fibers, such as hair, containing a) a bisulfite compound, b) a sulfate compound or urea, and c) a lactone or about 0.3% or greater, by weight, of ascorbic acid or a derivative thereof, based on the total weight of the composition and methods of waving keratinous fibers by applying such compositions to keratinous fibers. Also disclosed is a multi-unit cosmetic kit for treating a keratinous fiber containing a) a first unit containing a first composition containing a bisulfite compound and a sulfate compound or urea, and b) a second unit containing a second composition containing a lactone or ascorbic acid or a derivative thereof.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: September 22, 2015
    Assignee: L'OREAL
    Inventors: David W. Cannell, Christine Shin, Karen M. Saiewitz
  • Patent number: 9050265
    Abstract: Provided herein is a method of treating, preventing, or managing osteolysis in a subject, comprising administering to the subject a therapeutically effective amount of vitamin C, or a pharmaceutically acceptable salt, solvate, or hydrate thereof, in combination with vitamin K, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof, or a pharmaceutically acceptable salt, solvate, or hydrate thereof.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: June 9, 2015
    Assignee: Summa Health System
    Inventors: James M. Jamison, Thomas M. Miller, Deborah R. Neal, Mark Willam Kovacik, Michael John Askew, Richard Albert Mostardi
  • Publication number: 20150148317
    Abstract: A drug delivery system is provided for treatment of oxidative stress. The drug delivery system can include a therapeutic agent and a matrix. The therapeutic agent can include an antioxidant or steroid. The matrix can include a hydrogel, particle, microparticle, or nanoparticle. A method of treating injury, including peripheral nerve injury or spinal cord injury, is also provided. The method includes injecting the drug delivery system at the site of injury.
    Type: Application
    Filed: November 26, 2014
    Publication date: May 28, 2015
    Applicants: InVivo Therapeutics Corporation, Massachusetts Institute of Technology
    Inventors: Christopher D. Pritchard, Robert S. Langer, Francis M. Reynolds, Eric J. Woodard
  • Patent number: 9040066
    Abstract: This invention is based upon the discovery that a mixture of ethyl lactate and isoamyl lactate can be used to improve the penetration of active ingredients in skin care formulations through the outer layers of the stratum corneum and viable epidermis and into the dermis layer of the skin structure. The present invention more specifically discloses a method of rejuvenating skin comprising topically applying a topical formulation to the skin, wherein the topical formulation is comprised of ascorbic acid, an amino acid selected from the group consisting of phenylalanine and tyrosine, a non-toxic zinc salt, carnosic acid, ?-tocopherol, 0.01 weight percent to 20 weight percent of a mixture of ethyl lactate and isoamyl lactate, wherein the weight ratio of the ethyl lactate to the isoamyl lactate is within the range of 1:10 to 20:1, and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: May 26, 2015
    Assignee: Ad Lunam Labs, Inc.
    Inventors: William H. Beeson, Alvin T. Rockhill
  • Publication number: 20150141503
    Abstract: The present invention relates to solid, color-stable L-ascorbic acid compositions, which are in the form of a powder or granule. These improved compositions have a high amount of vitamin C and they have excellent color stability.
    Type: Application
    Filed: April 18, 2013
    Publication date: May 21, 2015
    Applicant: DSM IP ASSETS B.V.
    Inventors: Shan-Shan Sheu, Jean-claude Tritsch, Varaiya Chirag, Salmon Clive
  • Publication number: 20150139973
    Abstract: The present invention relates to an ophthalmological vehicle system for the permeation and/or for the active substance transport of ophthalmological active substances through the cornea and/or the sclera of the eye of mammals. This vehicle system assists the transport of the active substances through the cornea and/or the sclerotic tissue of the eye. The vehicle system is suitable for the prophylaxis and/or treatment of diseases of the front and/or back portion of the eye. Likewise, the present invention relates to an ophthalmological kit, comprising a special ophthalmological composition and also, as separate formulation, an ophthalmological active substance.
    Type: Application
    Filed: May 14, 2013
    Publication date: May 21, 2015
    Inventors: Ute Steinfeld, Frank Holzer, Hyeck Hee Lee, Markus Mahler
  • Publication number: 20150132238
    Abstract: Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 14, 2015
    Inventors: Adelya K. Leshchiner, Nancy E. Larsen, Edward G. Parent
  • Publication number: 20150132237
    Abstract: Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 14, 2015
    Inventors: Adelya K. Leshchiner, Nancy E. Larsen, Edward G. Parent
  • Publication number: 20150125496
    Abstract: The present application provides a dosage form and related methods for making the dosage form. The dosage form generally comprises a hydrophilic active ingredient, a plurality of solid, porous microcarriers, each having a hydrophobic surface, an optional hydrophobic encapsulant, and a hydrophilic delivery agent, wherein (i) the hydrophilic active ingredient is associated with the plurality of solid, porous microcarriers, (ii) the plurality of solid, porous microcarriers is encapsulated by the hydrophobic encapsulant, and (iii) the hydrophilic delivery agent is physically separated from a majority of the hydrophilic active ingredient by a boundary between the hydrophilic delivery agent and the hydrophobic encapsulant. In some embodiments, the dosage form is for topical application. In some additional embodiments, the plurality of solid, porous microcarriers is formed by modifying the microcarriers to increase their hydrophobicity.
    Type: Application
    Filed: November 4, 2014
    Publication date: May 7, 2015
    Inventor: Akira Yamamoto
  • Patent number: 9023889
    Abstract: The invention relates to the use of at least one ascorbic acid derivative for the fictionalization of matrices, and to specific ascorbic acid derivatives and processes for the preparation thereof.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: May 5, 2015
    Assignee: Merck Patent GmbH
    Inventors: Thomas Rudolph, Philipp Buehle, Herwig Buchholz
  • Patent number: 9023369
    Abstract: The invention relates to freeze-dried molded articles, containing ?50% by wt. of one or more active substances, and ?15% by wt. of one or more scaffold-forming agents, with proteins being excepted, as well as optionally one or more auxiliary substances, in each case based on the total composition of the freeze-dried molded article, whose 1% by wt. solution or suspension in water, at 20° C., has a pH value <7. Furthermore, the invention relates to methods for manufacturing these freeze-dried molded articles, the combination of such freeze-dried molded articles in kit-of-parts arrangements together with aqueous solutions, as well as the use of the freeze-dried molded articles and the kit-of-parts combinations for pharmaceutical and cosmetic application.
    Type: Grant
    Filed: April 20, 2010
    Date of Patent: May 5, 2015
    Inventors: Ralf Malessa, Claudia Elsinghorst, Fabian Kuhlmann, Uwe Wagner
  • Patent number: 9023383
    Abstract: A wound dressing material comprising: a wound dressing carrier, N-acetyl cysteine or a salt or derivative thereof, and a stabilized ascorbate. Suitably, the stabilized ascorbate comprises an ascorbate-2-polyphosphate. Also provided are wound dressing comprising the materials, methods of treatment with the materials, and methods of making the materials.
    Type: Grant
    Filed: May 5, 2010
    Date of Patent: May 5, 2015
    Assignee: KCI USA, Inc.
    Inventor: Lorraine Nisbet
  • Publication number: 20150119459
    Abstract: This invention relates to mild or weak acids and salt mixtures, such as Ascorbic acid, that when mechanically enhanced become dermal-appropriate, thereby allowing high levels of these compositions to be used in health-care, medical, pharmaceutical, nutraceutical and cosmoceutical products.
    Type: Application
    Filed: March 12, 2013
    Publication date: April 30, 2015
    Inventors: Burt R. Sookram, John W. Veenstra
  • Patent number: 9018252
    Abstract: The invention relates to stable liquid compositions containing the oxidized form of vitamin C known as dehydroascorbic acid (DHAA). The compositions comprise DHAA and a pharmacologically acceptable liquid organic polyol solvent. The polyol solvent comprises about 50% or greater of the total weight of the composition. The compositions are useful as dietary supplements, skin-enhancers, concentrates, or research solutions.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: April 28, 2015
    Inventors: Douglas Q Kitt, Jay P Kitt
  • Publication number: 20150110713
    Abstract: A method for treating cancer, preventing cancer or delaying the progression of a cancer in an animal or human comprising the step of: administering to the animal or the human having a cancer a composition in an amount effective to treat cancer, prevent cancer or delay the progression of cancer in the animal or the human. The composition comprises a pharmaceutically acceptable excipient, and ascorbate which is joined to a carrier structure containing an anti-cancer active agent, said carrier structure being capable of releasing the anti-cancer agent in the presence of a reactive oxygen species.
    Type: Application
    Filed: December 22, 2014
    Publication date: April 23, 2015
    Inventors: Anthony Manganaro, Karen Rockwell
  • Publication number: 20150104512
    Abstract: The present invention provides a rapidly disintegrating pharmaceutical formulation in the form of a coated tablet having increased mechanical strength, or hardness. The invention furthermore relates to a process for the production of the coated tablet and to the use of these formulations.
    Type: Application
    Filed: April 2, 2013
    Publication date: April 16, 2015
    Applicant: Merck Patent GmbH
    Inventors: Roberto Ognibene, Sandra Erika Bernhardt, Melanie Mechthild Breidung, Dieter Lubda, Hans-Leonhard Ohrem
  • Patent number: 8999313
    Abstract: The invention provides a colon cleansing solution comprising: a) 300 to 800 mmol per liter ascorbate anion provided by a mixture of: (i) ascorbic acid and (ii) one or more salts of ascorbic acid the components (i) and (ii) being present in a molar ratio of from 1:4.5 to 1:7.0; and b) 10 to 200 g per liter polyethylene glycol. The invention also provides methods an kits associated with, or making use of the solutions, and compositions for the preparation of the solutions.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: April 7, 2015
    Assignee: Norgine BV
    Inventors: Lucy Clayton, Alasdair Cockett, Mark Christodoulou, Ian Davidson, Lynn Farrag, Marc Halphen, Leighton Jones, Vanik Petrossian, Peter Stein, David Tisi, Alex Ungar, Jeffrey Worthington
  • Publication number: 20150079149
    Abstract: A strip, which is both edible and dissolvable, is provided comprising a film and a dosage of at least 2% of the reference daily intake (RDI) of at least one dietary supplement for malnutrition or to prevent/treat alcohol induced hangovers. A method for treating malnutrition and/or preventing and treating alcohol-induced hangovers using a dissolvable orally administered strip.
    Type: Application
    Filed: November 19, 2014
    Publication date: March 19, 2015
    Inventor: Alessandra Grassi
  • Patent number: 8980234
    Abstract: A composition in the form of an oil-in-water emulsion containing: an ester of fatty acid and of polyethylene glycol; an additional surfactant chosen from esters of C16-C22 fatty acid and of sorbitan and esters of C16-C22 fatty acid and of glycerol; a polycondensate of ethylene oxide and of propylene oxide consisting of polyethylene glycol and polypropylene glycol blocks; and an ascorbic acid compound or a salicylic acid compound. The composition has good stability, in particular after hours at 55° C. Application in caring for and making up keratinous substances.
    Type: Grant
    Filed: March 9, 2009
    Date of Patent: March 17, 2015
    Assignee: L'Oreal
    Inventor: Aldo Monello
  • Patent number: 8969411
    Abstract: A formulation for a stable ascorbic acid composition which, in a simplified form, is comprised of ascorbic acid in solution with a hygroscopic compound (i.e., a substance with the ability to attract water molecules from the surrounding environment through either absorption or adsorption). Also disclosed herein are methods for the production of such compounds and methods of using such compounds in the prevention, inhibition and treatment of striae gravidarum, radiation dermatitis, rhytids, lentigoes, dyschromia, sun-damage induced hyperpigmentation, cellulite, scars, purpura, skin firming, muscle, tendon and ligament improvement and repair, and hair conditions, among other skin diseases or conditions.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: March 3, 2015
    Inventor: David L. Kaplan
  • Patent number: 8962039
    Abstract: Use of high doses above 1 gm per day of ascorbic acid or the derivatives thereof for the treatment of neurodegenerative and neuro-muscular degenerative diseases and disorders, in particular amytrophic lateral sclerosis, multiple sclerosis, alzheimer's disease, parkinson's disease, and muscular dystrophy is disclosed. Preferably the dose includes mannitol which facilitates the delivery of ascorbic acid to the target cells in the brain. Still further the said dose includes zinc citrate for preventing formation of kidney stones. Dose compositions for various routes of application such as oral, intravenous, intramuscular, nasal and in the form of transdermal patches are discussed.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: February 24, 2015
    Inventors: Munisekhar Medasani, Satyasayee Babu Divi, Satya Laxmi Priyanka Palempati
  • Patent number: 8957111
    Abstract: A compound of formula (ascorbate)2Sr:(M+a)x(ascorbate)y, or ascorbate)2Sr:Ca(ascorbate)2, a composition containing the same, a method of making the same and a method of administering the same as a supplement.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: February 17, 2015
    Assignee: Nutraceutical Corporation
    Inventors: Shayne Morris, Richard Bush
  • Publication number: 20150045426
    Abstract: A complex formed of at least one molecule of 5-(1,2-dihydroxy-ethyl)-3,4-dihydroxy-5H-furan-2-one or a derivative covalently bonded with at least one hydrocarbon radical with formula (A) as follows: wherein: •-m 1=1, 2, 3, 4, 5 or 6; •-m 2=0, 1, 2, 3, 4, 5 or 6; and represents the site of the bond with the molecule of 5-(1,2-dihydroxy-ethyl)-3,4-dihydroxy-5H-furan-2-one or derivative.
    Type: Application
    Filed: March 14, 2013
    Publication date: February 12, 2015
    Inventors: Patrick Couvreur, Fatima Zouhiri, Ruxandra Gref, Didier Desmaele
  • Publication number: 20150030662
    Abstract: Methods of generating functional human brown adipocytes, comprising exposing human stem cells, progenitor cells, or white adipocytes to culture with an differentiation cocktail that comprises one or more browning agents (e.g., one or more macromolecular crowders), and optionally one or more adipogenic agents, are described, as are populations of human brown adipocytes generated by the methods, and uses for the populations. Methods of generating functional human brown adipocytes in an individual, such as by administering a pharmaceutical composition comprising an differentiation cocktail, are also described.
    Type: Application
    Filed: March 12, 2013
    Publication date: January 29, 2015
    Applicants: National University of Singapore, Auckland Uniservices LTD
    Inventors: Michael Raghunath, Michelle Hui Ching Lee, Allan Sheppard
  • Patent number: 8940281
    Abstract: Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: January 27, 2015
    Assignee: LuroMed LLC
    Inventors: Adelya K. Leshchiner, Nancy E. Larsen, Edward G. Parent
  • Publication number: 20150017103
    Abstract: The present invention relates to a waterless composition and foam as a vehicle in which an active pharmaceutical or cosmetic agent, when added is stable or stabilized by or its destabilization is impeded by the presence of a modulating agent. The pharmaceutical or cosmetic composition and foam, includes: a waterless solvent, a modulating agent and one or more active pharmaceutical or cosmetic agents. The present invention also relates to a method of treatment administering the waterless composition and foam.
    Type: Application
    Filed: October 3, 2013
    Publication date: January 15, 2015
    Applicant: Foamix Ltd.
    Inventors: Dov Tamarkin, Meir Eini, Doron Friedman, Tal Berman, David Schuz
  • Patent number: 8927528
    Abstract: A composition to be administered to a mammal for treating hearing loss is disclosed herein. The composition consists essentially of a biologically effective amount of vitamin A, vitamin C, vitamin E, and a vasodilator comprising magnesium. The composition optionally includes a withanolide and/or resveratrol. The vitamin A, vitamin C, vitamin E, and the vasodilator comprising magnesium provides an additive effect that is equal to or greater than a sum of the effects of the individual components.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: January 6, 2015
    Assignee: The Regents of the University of Michigan
    Inventors: Josef Miller, Colleen LePrell, Jochen Schact, Diane Prieskorn
  • Patent number: 8927554
    Abstract: The present disclosure relates to compositions containing certain pyrimidine compounds such as minoxidil and/or certain pyrimidine sulfate (inner salt) compounds such as minoxidil sulfate and especially compositions containing pyrimidine compounds in combination with an admixtures comprising at least one antioxidant, at least one organic acid and a select fatty acid mixture. The present disclosure also relates to use of the compositions to grow and/or regrow hair and/or prevent hair loss in mammals and particularly in humans.
    Type: Grant
    Filed: May 15, 2012
    Date of Patent: January 6, 2015
    Assignee: McNeil-PPC, Inc.
    Inventors: Longsheng Hu, Virginia Streusand Goldman, Josephine A. Minerva, Susan Wendling
  • Patent number: 8920837
    Abstract: The novel sustained release dosage form comprising an active agent and a combination of a non-swelling pH dependent release retardant and a non swelling pH independent release retardant polymer which provides pH-independent drug release for a considerable period of time after administration.
    Type: Grant
    Filed: July 3, 2006
    Date of Patent: December 30, 2014
    Assignee: Rubicon Research Private Limited
    Inventors: Pratibha S. Pilgaonkar, Maharukh T. Rustomjee, Anilkumar S. Gandhi, Paras R. Jain, Atul A. Kelkar
  • Patent number: 8921312
    Abstract: Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: December 30, 2014
    Assignee: University of South Florida
    Inventors: Kurt Musselmann, John R. Hassell, Brad Kane, Bridgette Alexandrou
  • Publication number: 20140363476
    Abstract: Disclosed is a composition comprising ascorbic acid or a derivative thereof, a silicone containing compound, and an essential oil, wherein at least 50% of the initial amount of the ascorbic acid in the composition remains stable when the composition is stored for at least 1 month at room temperature. The composition can be non-aqueous.
    Type: Application
    Filed: July 11, 2014
    Publication date: December 11, 2014
    Inventor: Isaac THOMAS
  • Publication number: 20140363523
    Abstract: The present invention provides a compound of Formula (I), wherein: each X is independently hydrogen or deuterium; and at least one X is deuterium.
    Type: Application
    Filed: January 17, 2013
    Publication date: December 11, 2014
    Inventor: Adam Morgan
  • Publication number: 20140364365
    Abstract: A mask for skin care includes a fiber substrate, wherein the fiber substrate is woven or nonwoven, and includes modified fibers, and the modified fibers are cellulose fibers with at least one hydrophilic functional group grafted on. The grafted ratio of the modified fibers is in the range from 5% to 30%, and the modified fibers can effectively improve the moisture absorption and the moisture-retaining capacity of the mask for skin care.
    Type: Application
    Filed: March 17, 2014
    Publication date: December 11, 2014
    Applicant: Far Eastern New Century Corporation
    Inventors: Yong-Yi Wu, Mei-Ting Fan Chiang, Zij-Jyun Fang
  • Publication number: 20140356340
    Abstract: Nutritional products having improved cohesiveness of food boluses and methods of making and using same are provided. The nutritional products may include nutritional compositions and high molecular weight, water-soluble polymers such that the nutritional products have extensional viscosities that provide improved cohesiveness to the nutritional products and Trouton ratios of at least 6. Methods of administering such nutritional products to patients having impaired swallowing ability and/or dysphagia are also provided.
    Type: Application
    Filed: December 17, 2012
    Publication date: December 4, 2014
    Inventors: Adam Burbidge, Jan Engmann, Simina Popa Nita
  • Patent number: 8901109
    Abstract: This invention relates to a composition containing quercetin, vitamin B3, vitamin C, and folic acid. Also disclosed is a method of using the composition for enhancing physical or mental performance or treating various diseases or disorders.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: December 2, 2014
    Assignee: Quercegen Pharmaceuticals LLC
    Inventor: Thomas Christian Lines
  • Patent number: 8895473
    Abstract: Present invention provides an aqueous composition made from selected biochemical substances that will help with the low temperature tolerance of plants and thus to avoid “chilling injury” and to promote better recovery from such injury, when the solution is applied to crop plants prior to the arrival of cold snap or period of low temperature.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: November 25, 2014
    Assignee: CH Biotech R&D Co., Ltd.
    Inventors: Denny Ng, Kai Xia