Ascorbic Acid Or Derivative (e.g., Vitamin C, Etc.) Patents (Class 514/474)
-
Patent number: 9040066Abstract: This invention is based upon the discovery that a mixture of ethyl lactate and isoamyl lactate can be used to improve the penetration of active ingredients in skin care formulations through the outer layers of the stratum corneum and viable epidermis and into the dermis layer of the skin structure. The present invention more specifically discloses a method of rejuvenating skin comprising topically applying a topical formulation to the skin, wherein the topical formulation is comprised of ascorbic acid, an amino acid selected from the group consisting of phenylalanine and tyrosine, a non-toxic zinc salt, carnosic acid, ?-tocopherol, 0.01 weight percent to 20 weight percent of a mixture of ethyl lactate and isoamyl lactate, wherein the weight ratio of the ethyl lactate to the isoamyl lactate is within the range of 1:10 to 20:1, and a pharmaceutically acceptable carrier.Type: GrantFiled: April 7, 2014Date of Patent: May 26, 2015Assignee: Ad Lunam Labs, Inc.Inventors: William H. Beeson, Alvin T. Rockhill
-
Publication number: 20150139973Abstract: The present invention relates to an ophthalmological vehicle system for the permeation and/or for the active substance transport of ophthalmological active substances through the cornea and/or the sclera of the eye of mammals. This vehicle system assists the transport of the active substances through the cornea and/or the sclerotic tissue of the eye. The vehicle system is suitable for the prophylaxis and/or treatment of diseases of the front and/or back portion of the eye. Likewise, the present invention relates to an ophthalmological kit, comprising a special ophthalmological composition and also, as separate formulation, an ophthalmological active substance.Type: ApplicationFiled: May 14, 2013Publication date: May 21, 2015Inventors: Ute Steinfeld, Frank Holzer, Hyeck Hee Lee, Markus Mahler
-
Publication number: 20150141503Abstract: The present invention relates to solid, color-stable L-ascorbic acid compositions, which are in the form of a powder or granule. These improved compositions have a high amount of vitamin C and they have excellent color stability.Type: ApplicationFiled: April 18, 2013Publication date: May 21, 2015Applicant: DSM IP ASSETS B.V.Inventors: Shan-Shan Sheu, Jean-claude Tritsch, Varaiya Chirag, Salmon Clive
-
Publication number: 20150132238Abstract: Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.Type: ApplicationFiled: January 23, 2015Publication date: May 14, 2015Inventors: Adelya K. Leshchiner, Nancy E. Larsen, Edward G. Parent
-
Publication number: 20150132237Abstract: Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.Type: ApplicationFiled: January 23, 2015Publication date: May 14, 2015Inventors: Adelya K. Leshchiner, Nancy E. Larsen, Edward G. Parent
-
Publication number: 20150125496Abstract: The present application provides a dosage form and related methods for making the dosage form. The dosage form generally comprises a hydrophilic active ingredient, a plurality of solid, porous microcarriers, each having a hydrophobic surface, an optional hydrophobic encapsulant, and a hydrophilic delivery agent, wherein (i) the hydrophilic active ingredient is associated with the plurality of solid, porous microcarriers, (ii) the plurality of solid, porous microcarriers is encapsulated by the hydrophobic encapsulant, and (iii) the hydrophilic delivery agent is physically separated from a majority of the hydrophilic active ingredient by a boundary between the hydrophilic delivery agent and the hydrophobic encapsulant. In some embodiments, the dosage form is for topical application. In some additional embodiments, the plurality of solid, porous microcarriers is formed by modifying the microcarriers to increase their hydrophobicity.Type: ApplicationFiled: November 4, 2014Publication date: May 7, 2015Inventor: Akira Yamamoto
-
Patent number: 9023383Abstract: A wound dressing material comprising: a wound dressing carrier, N-acetyl cysteine or a salt or derivative thereof, and a stabilized ascorbate. Suitably, the stabilized ascorbate comprises an ascorbate-2-polyphosphate. Also provided are wound dressing comprising the materials, methods of treatment with the materials, and methods of making the materials.Type: GrantFiled: May 5, 2010Date of Patent: May 5, 2015Assignee: KCI USA, Inc.Inventor: Lorraine Nisbet
-
Patent number: 9023889Abstract: The invention relates to the use of at least one ascorbic acid derivative for the fictionalization of matrices, and to specific ascorbic acid derivatives and processes for the preparation thereof.Type: GrantFiled: June 27, 2007Date of Patent: May 5, 2015Assignee: Merck Patent GmbHInventors: Thomas Rudolph, Philipp Buehle, Herwig Buchholz
-
Patent number: 9023369Abstract: The invention relates to freeze-dried molded articles, containing ?50% by wt. of one or more active substances, and ?15% by wt. of one or more scaffold-forming agents, with proteins being excepted, as well as optionally one or more auxiliary substances, in each case based on the total composition of the freeze-dried molded article, whose 1% by wt. solution or suspension in water, at 20° C., has a pH value <7. Furthermore, the invention relates to methods for manufacturing these freeze-dried molded articles, the combination of such freeze-dried molded articles in kit-of-parts arrangements together with aqueous solutions, as well as the use of the freeze-dried molded articles and the kit-of-parts combinations for pharmaceutical and cosmetic application.Type: GrantFiled: April 20, 2010Date of Patent: May 5, 2015Inventors: Ralf Malessa, Claudia Elsinghorst, Fabian Kuhlmann, Uwe Wagner
-
Publication number: 20150119459Abstract: This invention relates to mild or weak acids and salt mixtures, such as Ascorbic acid, that when mechanically enhanced become dermal-appropriate, thereby allowing high levels of these compositions to be used in health-care, medical, pharmaceutical, nutraceutical and cosmoceutical products.Type: ApplicationFiled: March 12, 2013Publication date: April 30, 2015Inventors: Burt R. Sookram, John W. Veenstra
-
Patent number: 9018252Abstract: The invention relates to stable liquid compositions containing the oxidized form of vitamin C known as dehydroascorbic acid (DHAA). The compositions comprise DHAA and a pharmacologically acceptable liquid organic polyol solvent. The polyol solvent comprises about 50% or greater of the total weight of the composition. The compositions are useful as dietary supplements, skin-enhancers, concentrates, or research solutions.Type: GrantFiled: November 14, 2012Date of Patent: April 28, 2015Inventors: Douglas Q Kitt, Jay P Kitt
-
Publication number: 20150110713Abstract: A method for treating cancer, preventing cancer or delaying the progression of a cancer in an animal or human comprising the step of: administering to the animal or the human having a cancer a composition in an amount effective to treat cancer, prevent cancer or delay the progression of cancer in the animal or the human. The composition comprises a pharmaceutically acceptable excipient, and ascorbate which is joined to a carrier structure containing an anti-cancer active agent, said carrier structure being capable of releasing the anti-cancer agent in the presence of a reactive oxygen species.Type: ApplicationFiled: December 22, 2014Publication date: April 23, 2015Inventors: Anthony Manganaro, Karen Rockwell
-
Publication number: 20150104512Abstract: The present invention provides a rapidly disintegrating pharmaceutical formulation in the form of a coated tablet having increased mechanical strength, or hardness. The invention furthermore relates to a process for the production of the coated tablet and to the use of these formulations.Type: ApplicationFiled: April 2, 2013Publication date: April 16, 2015Applicant: Merck Patent GmbHInventors: Roberto Ognibene, Sandra Erika Bernhardt, Melanie Mechthild Breidung, Dieter Lubda, Hans-Leonhard Ohrem
-
Patent number: 8999313Abstract: The invention provides a colon cleansing solution comprising: a) 300 to 800 mmol per liter ascorbate anion provided by a mixture of: (i) ascorbic acid and (ii) one or more salts of ascorbic acid the components (i) and (ii) being present in a molar ratio of from 1:4.5 to 1:7.0; and b) 10 to 200 g per liter polyethylene glycol. The invention also provides methods an kits associated with, or making use of the solutions, and compositions for the preparation of the solutions.Type: GrantFiled: March 24, 2014Date of Patent: April 7, 2015Assignee: Norgine BVInventors: Lucy Clayton, Alasdair Cockett, Mark Christodoulou, Ian Davidson, Lynn Farrag, Marc Halphen, Leighton Jones, Vanik Petrossian, Peter Stein, David Tisi, Alex Ungar, Jeffrey Worthington
-
Publication number: 20150079149Abstract: A strip, which is both edible and dissolvable, is provided comprising a film and a dosage of at least 2% of the reference daily intake (RDI) of at least one dietary supplement for malnutrition or to prevent/treat alcohol induced hangovers. A method for treating malnutrition and/or preventing and treating alcohol-induced hangovers using a dissolvable orally administered strip.Type: ApplicationFiled: November 19, 2014Publication date: March 19, 2015Inventor: Alessandra Grassi
-
Patent number: 8980234Abstract: A composition in the form of an oil-in-water emulsion containing: an ester of fatty acid and of polyethylene glycol; an additional surfactant chosen from esters of C16-C22 fatty acid and of sorbitan and esters of C16-C22 fatty acid and of glycerol; a polycondensate of ethylene oxide and of propylene oxide consisting of polyethylene glycol and polypropylene glycol blocks; and an ascorbic acid compound or a salicylic acid compound. The composition has good stability, in particular after hours at 55° C. Application in caring for and making up keratinous substances.Type: GrantFiled: March 9, 2009Date of Patent: March 17, 2015Assignee: L'OrealInventor: Aldo Monello
-
Patent number: 8969411Abstract: A formulation for a stable ascorbic acid composition which, in a simplified form, is comprised of ascorbic acid in solution with a hygroscopic compound (i.e., a substance with the ability to attract water molecules from the surrounding environment through either absorption or adsorption). Also disclosed herein are methods for the production of such compounds and methods of using such compounds in the prevention, inhibition and treatment of striae gravidarum, radiation dermatitis, rhytids, lentigoes, dyschromia, sun-damage induced hyperpigmentation, cellulite, scars, purpura, skin firming, muscle, tendon and ligament improvement and repair, and hair conditions, among other skin diseases or conditions.Type: GrantFiled: January 10, 2013Date of Patent: March 3, 2015Inventor: David L. Kaplan
-
Patent number: 8962039Abstract: Use of high doses above 1 gm per day of ascorbic acid or the derivatives thereof for the treatment of neurodegenerative and neuro-muscular degenerative diseases and disorders, in particular amytrophic lateral sclerosis, multiple sclerosis, alzheimer's disease, parkinson's disease, and muscular dystrophy is disclosed. Preferably the dose includes mannitol which facilitates the delivery of ascorbic acid to the target cells in the brain. Still further the said dose includes zinc citrate for preventing formation of kidney stones. Dose compositions for various routes of application such as oral, intravenous, intramuscular, nasal and in the form of transdermal patches are discussed.Type: GrantFiled: September 2, 2010Date of Patent: February 24, 2015Inventors: Munisekhar Medasani, Satyasayee Babu Divi, Satya Laxmi Priyanka Palempati
-
Patent number: 8957111Abstract: A compound of formula (ascorbate)2Sr:(M+a)x(ascorbate)y, or ascorbate)2Sr:Ca(ascorbate)2, a composition containing the same, a method of making the same and a method of administering the same as a supplement.Type: GrantFiled: February 11, 2013Date of Patent: February 17, 2015Assignee: Nutraceutical CorporationInventors: Shayne Morris, Richard Bush
-
Publication number: 20150045426Abstract: A complex formed of at least one molecule of 5-(1,2-dihydroxy-ethyl)-3,4-dihydroxy-5H-furan-2-one or a derivative covalently bonded with at least one hydrocarbon radical with formula (A) as follows: wherein: •-m 1=1, 2, 3, 4, 5 or 6; •-m 2=0, 1, 2, 3, 4, 5 or 6; and represents the site of the bond with the molecule of 5-(1,2-dihydroxy-ethyl)-3,4-dihydroxy-5H-furan-2-one or derivative.Type: ApplicationFiled: March 14, 2013Publication date: February 12, 2015Inventors: Patrick Couvreur, Fatima Zouhiri, Ruxandra Gref, Didier Desmaele
-
Publication number: 20150030662Abstract: Methods of generating functional human brown adipocytes, comprising exposing human stem cells, progenitor cells, or white adipocytes to culture with an differentiation cocktail that comprises one or more browning agents (e.g., one or more macromolecular crowders), and optionally one or more adipogenic agents, are described, as are populations of human brown adipocytes generated by the methods, and uses for the populations. Methods of generating functional human brown adipocytes in an individual, such as by administering a pharmaceutical composition comprising an differentiation cocktail, are also described.Type: ApplicationFiled: March 12, 2013Publication date: January 29, 2015Applicants: National University of Singapore, Auckland Uniservices LTDInventors: Michael Raghunath, Michelle Hui Ching Lee, Allan Sheppard
-
Patent number: 8940281Abstract: Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.Type: GrantFiled: March 18, 2014Date of Patent: January 27, 2015Assignee: LuroMed LLCInventors: Adelya K. Leshchiner, Nancy E. Larsen, Edward G. Parent
-
Publication number: 20150017103Abstract: The present invention relates to a waterless composition and foam as a vehicle in which an active pharmaceutical or cosmetic agent, when added is stable or stabilized by or its destabilization is impeded by the presence of a modulating agent. The pharmaceutical or cosmetic composition and foam, includes: a waterless solvent, a modulating agent and one or more active pharmaceutical or cosmetic agents. The present invention also relates to a method of treatment administering the waterless composition and foam.Type: ApplicationFiled: October 3, 2013Publication date: January 15, 2015Applicant: Foamix Ltd.Inventors: Dov Tamarkin, Meir Eini, Doron Friedman, Tal Berman, David Schuz
-
Patent number: 8927528Abstract: A composition to be administered to a mammal for treating hearing loss is disclosed herein. The composition consists essentially of a biologically effective amount of vitamin A, vitamin C, vitamin E, and a vasodilator comprising magnesium. The composition optionally includes a withanolide and/or resveratrol. The vitamin A, vitamin C, vitamin E, and the vasodilator comprising magnesium provides an additive effect that is equal to or greater than a sum of the effects of the individual components.Type: GrantFiled: November 16, 2012Date of Patent: January 6, 2015Assignee: The Regents of the University of MichiganInventors: Josef Miller, Colleen LePrell, Jochen Schact, Diane Prieskorn
-
Patent number: 8927554Abstract: The present disclosure relates to compositions containing certain pyrimidine compounds such as minoxidil and/or certain pyrimidine sulfate (inner salt) compounds such as minoxidil sulfate and especially compositions containing pyrimidine compounds in combination with an admixtures comprising at least one antioxidant, at least one organic acid and a select fatty acid mixture. The present disclosure also relates to use of the compositions to grow and/or regrow hair and/or prevent hair loss in mammals and particularly in humans.Type: GrantFiled: May 15, 2012Date of Patent: January 6, 2015Assignee: McNeil-PPC, Inc.Inventors: Longsheng Hu, Virginia Streusand Goldman, Josephine A. Minerva, Susan Wendling
-
Patent number: 8921312Abstract: Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.Type: GrantFiled: October 14, 2010Date of Patent: December 30, 2014Assignee: University of South FloridaInventors: Kurt Musselmann, John R. Hassell, Brad Kane, Bridgette Alexandrou
-
Patent number: 8920837Abstract: The novel sustained release dosage form comprising an active agent and a combination of a non-swelling pH dependent release retardant and a non swelling pH independent release retardant polymer which provides pH-independent drug release for a considerable period of time after administration.Type: GrantFiled: July 3, 2006Date of Patent: December 30, 2014Assignee: Rubicon Research Private LimitedInventors: Pratibha S. Pilgaonkar, Maharukh T. Rustomjee, Anilkumar S. Gandhi, Paras R. Jain, Atul A. Kelkar
-
Publication number: 20140363476Abstract: Disclosed is a composition comprising ascorbic acid or a derivative thereof, a silicone containing compound, and an essential oil, wherein at least 50% of the initial amount of the ascorbic acid in the composition remains stable when the composition is stored for at least 1 month at room temperature. The composition can be non-aqueous.Type: ApplicationFiled: July 11, 2014Publication date: December 11, 2014Inventor: Isaac THOMAS
-
Publication number: 20140364365Abstract: A mask for skin care includes a fiber substrate, wherein the fiber substrate is woven or nonwoven, and includes modified fibers, and the modified fibers are cellulose fibers with at least one hydrophilic functional group grafted on. The grafted ratio of the modified fibers is in the range from 5% to 30%, and the modified fibers can effectively improve the moisture absorption and the moisture-retaining capacity of the mask for skin care.Type: ApplicationFiled: March 17, 2014Publication date: December 11, 2014Applicant: Far Eastern New Century CorporationInventors: Yong-Yi Wu, Mei-Ting Fan Chiang, Zij-Jyun Fang
-
Publication number: 20140363523Abstract: The present invention provides a compound of Formula (I), wherein: each X is independently hydrogen or deuterium; and at least one X is deuterium.Type: ApplicationFiled: January 17, 2013Publication date: December 11, 2014Inventor: Adam Morgan
-
Publication number: 20140356340Abstract: Nutritional products having improved cohesiveness of food boluses and methods of making and using same are provided. The nutritional products may include nutritional compositions and high molecular weight, water-soluble polymers such that the nutritional products have extensional viscosities that provide improved cohesiveness to the nutritional products and Trouton ratios of at least 6. Methods of administering such nutritional products to patients having impaired swallowing ability and/or dysphagia are also provided.Type: ApplicationFiled: December 17, 2012Publication date: December 4, 2014Inventors: Adam Burbidge, Jan Engmann, Simina Popa Nita
-
Patent number: 8901109Abstract: This invention relates to a composition containing quercetin, vitamin B3, vitamin C, and folic acid. Also disclosed is a method of using the composition for enhancing physical or mental performance or treating various diseases or disorders.Type: GrantFiled: June 23, 2010Date of Patent: December 2, 2014Assignee: Quercegen Pharmaceuticals LLCInventor: Thomas Christian Lines
-
Patent number: 8895473Abstract: Present invention provides an aqueous composition made from selected biochemical substances that will help with the low temperature tolerance of plants and thus to avoid “chilling injury” and to promote better recovery from such injury, when the solution is applied to crop plants prior to the arrival of cold snap or period of low temperature.Type: GrantFiled: April 5, 2012Date of Patent: November 25, 2014Assignee: CH Biotech R&D Co., Ltd.Inventors: Denny Ng, Kai Xia
-
Patent number: 8889194Abstract: Disclosed is a compound and methods for use by an individual attempting to reduce or cease tobacco smoking or one exposed to environmental tobacco smoke. The compound includes a first component blocking nicotine receptor sites to reduce nicotine cravings or withdrawal symptoms, a second component increasing serotonin levels and acting synergistically with the first component to reduce nicotine cravings or withdrawal symptoms, assisting in maintaining body weight and reducing increased stress and anxiety, and a third component acting synergistically with the first and/or second component to reduce nicotine cravings or withdrawal symptoms, maintain body weight, and/or reduce increased stress and anxiety. The third component comprises a supplement that replenishes depleted body substance(s), repairs damaged body substance(s), and/or ameliorates the impaired function of body substance(s). Some combination of the first, second, and third component alters the perceived taste of tobacco smoke.Type: GrantFiled: September 29, 2010Date of Patent: November 18, 2014Inventor: Harlan Clayton Bieley
-
Publication number: 20140335153Abstract: A method of preparing a thin film, the method comprising: (a) mixing a lipid, emulsifier, and solvent to provide a uniform first mixture; (b) contacting an active ingredient with the uniform first mixture to provide a thickened second mixture; (c) contacting a binder with the thickened second mixture to provide a slurry; and (d) hot extruding, casting, and condensing the slurry to provide the thin film; or cooling, shearing, mixing, casting, and condensing the slurry to provide the thin film.Type: ApplicationFiled: October 31, 2013Publication date: November 13, 2014Applicant: CURE Pharmaceutical CorporationInventors: Eric Allen, Robert Steven Davidson, Jose Bernardo
-
Patent number: 8883221Abstract: Micronutrient combination product, wherein the micronutrient combination product comprises zeaxanthin, lutein, zinc and copper.Type: GrantFiled: December 17, 2004Date of Patent: November 11, 2014Assignee: Bausch & Lomb IncorporatedInventors: Guenter Bellmann, Gudrun Claus-Herz
-
Patent number: 8871773Abstract: The present disclosure relates to methods of retarding hair loss or facilitating hair growth and/or regrowth. More specifically, the present disclosure relates to methods of using the disclosed compositions to increase the rate of terminal hair growth and/or regrowth in a mammal.Type: GrantFiled: June 3, 2013Date of Patent: October 28, 2014Assignee: McNeil-PPC, Inc.Inventors: Longsheng Hu, Virginia Streusand Goldman, Josephine A. Minerva, Susan Wendling
-
Patent number: 8858991Abstract: Disclosed herein are controlled-release oral pharmaceutical dosage forms comprising MGBG, and their application for the improved treatment of diseases with reduced side effects and/or longer time at maximum concentration.Type: GrantFiled: January 19, 2012Date of Patent: October 14, 2014Assignee: Pathologica LLCInventors: John McKearn, Jeremy Blitzer
-
Patent number: 8859613Abstract: The invention provides compositions for preventing or treating kidney disease and improving kidney function comprising at least two ingredients selected from the group consisting of antioxidants and mitochondrial cofactors in amounts sufficient for preventing or treating kidney disease or for improving kidney function and methods for preventing and treating kidney disease or improving kidney function comprising administering such compositions to an animal susceptible to or suffering from kidney disease or impaired kidney function. In a preferred embodiment, the composition is admixed with one or more food ingredients to produce a food composition useful for preventing or treating kidney disease and improving kidney function, particularly in senior animals.Type: GrantFiled: June 20, 2013Date of Patent: October 14, 2014Assignee: Hill's Pet Nutrition, Inc.Inventors: Steven Curtis Zicker, Karen Joy Wedekind
-
Patent number: 8859618Abstract: This invention is a composition comprising a cyclic siloxane, a silicone occlusive fluid, a silicone occlusive gel, and a silicone resin powder. The composition is useful for wound healing.Type: GrantFiled: September 19, 2013Date of Patent: October 14, 2014Assignee: Valeant Pharmaceuticals InternationalInventors: Irwin Palefsky, Ni'Kita Wilson
-
Publication number: 20140302169Abstract: A method wherein subjects having or at risk for having hyperopia, presbyopia or astigmatism are administered a composition having an effective amount of ocular antioxidants, including specifically macular pigments, to prevent, treat, or delay the onset of age-related macular degeneration (AMD).Type: ApplicationFiled: June 18, 2014Publication date: October 9, 2014Inventor: Richard Roberts
-
Patent number: 8853172Abstract: The present invention provides an anti-plant virus agent which exhibits preventative and therapeutic effects on plant virus diseases. The anti-plant virus agent of the present invention is characterized by containing at least one compound selected from the group consisting of ascorbic acid derivatives represented by Formula (I) (wherein, R1 to R4 each independently represents a hydrogen atom, —SO3H, —PO3H2, a glycosyl group, or —COR11, wherein R11 represents an unsubstituted or substituted C1-30 alkyl group, or an unsubstituted or substituted C2-30 alkenyl group, with the proviso that R1 to R4 may not all be hydrogen atoms at the same time), and salts thereof.Type: GrantFiled: September 9, 2010Date of Patent: October 7, 2014Assignees: National University Corporation Hokkaido University, Nippon Soda Co., Ltd.Inventors: Chikara Masuta, Hanako Shimura, Shinsuke Sano, Takako Fukagawa
-
Publication number: 20140294787Abstract: Nutritional products having improved cohesiveness of food boluses and methods of making and using same are provided. The nutritional products may include nutritional compositions and high molecular weight, water-soluble polymers such that the nutritional products have extensional viscosities that provide improved cohesiveness to the nutritional products and Trouton ratios of at least 6. Methods of administering such nutritional products to patients having impaired swallowing ability and/or dysphagia are also provided.Type: ApplicationFiled: March 1, 2012Publication date: October 2, 2014Inventors: Adam Stewart Burbidge, Jan Engmann, Simina Popa Nita
-
Publication number: 20140286882Abstract: The present invention provides for a formulation manufactured by a process comprising: admixing at least one elastomer with a first dispersant to form a gel; admixing a second dispersant with the gel; and admixing at least one active, such as ascorbic acid, with the gel to form a delivery system with an active in the formulation retains its stability, functionality and aesthetics.Type: ApplicationFiled: March 21, 2013Publication date: September 25, 2014Inventors: Julius Zecchino, Alexander Zecchino
-
Publication number: 20140286884Abstract: Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.Type: ApplicationFiled: March 18, 2014Publication date: September 25, 2014Applicant: LUROMED LLCInventors: Adelya K. Leshchiner, Nancy E. Larsen, Edward G. Parent
-
Publication number: 20140286883Abstract: The present invention provides for a formulation manufactured by a process comprising: admixing at least one elastomer with a first dispersant to form a gel; admixing a second dispersant with the gel; and admixing at least one active, such as ascorbic acid, with the gel to form a delivery system with an active in the formulation retains its stability, functionality and aesthetics.Type: ApplicationFiled: March 18, 2014Publication date: September 25, 2014Inventors: Julius Zecchino, Alexander Zecchino
-
Publication number: 20140275240Abstract: Combinations of betaine and vitamin C are used to suppress or prevent malignant tumors or to treat viruses, e.g., by combining the two ingredients in a product consumed by a human, dog, or cat, such as an aqueous liquid such as grape juice, the ingredients being provided in containers with instructions for use, or in finished products, especially with support of tests demonstrating the effectiveness of the treatment for, e.g., preventing tumors in populations known to be at risk of developing tumors, or, treating existing cancers in combination with other cancer drugs such as anastrozole and/or fulvestrant and/or artemisinin either concurrently or sequentially to prevent the cancer from growing when the cancer drug is not being used, or in the treatment of viruses.Type: ApplicationFiled: March 16, 2013Publication date: September 18, 2014Inventors: Robert Benson Aylor, Leigh Heather Makover, Robyn Aylor Haines
-
Patent number: 8834905Abstract: A wound dressing composition comprising a non-viable cell lysate or releasate derived from a hepatocyte cell or an inflammatory cell such as a macrophage. Also provided are wound dressings comprising such compositions, methods of making such compositions, and the use of such compositions for the treatment of wounds.Type: GrantFiled: November 2, 2007Date of Patent: September 16, 2014Assignee: Systagenix Wound Management (US), Inc.Inventors: Rachael Louise Clark, Breda Mary Cullen, Lindsay Matheson
-
Patent number: 8828960Abstract: The invention relates to pharmaceutical compositions that provide sustained-release of a pharmaceutically active compound and to methods of treating or preventing a condition in an animal by administering the pharmaceutical compositions to the animal. When the pharmaceutical compositions are administered to an animal by injection, they form a drug depot that releases the pharmaceutically active compound over time. The pharmaceutical compositions can also be administered orally.Type: GrantFiled: July 11, 2008Date of Patent: September 9, 2014Assignee: IDEXX Laboratories, Inc.Inventors: Yerramilli V.S.N. Murthy, Michael Atkinson
-
Patent number: 8829044Abstract: The present invention relates to a stabilized vitamin C derivative with a peptide molecule linked to vitamin C or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a composition containing the same.Type: GrantFiled: September 5, 2006Date of Patent: September 9, 2014Assignee: Peotron Co. Ltd.Inventors: Jong-Il Park, Heung-Jae Kim, Dong-Won Kim, Chae-Jin Lim, Jong-Phil Kang, Kyeong-Yong Park, Seok-Jeong Yoon, Seon-Deok Kwon, Ho-Il Choi