Publication number: 20030078296
Abstract: Angiogenesis, tumor growth, and metalloproteinase 2 (MMP2) interaction with integrin-&agr;v&bgr;3 are inhibited by an inhibitor compound of formula (I): wherein G1 and G2 are each independently NH—C(O)—O—R1, —NH—C(O)—O—(CH2)v—(C6H4)—X3, —NH—C(O)—NH—(CH2)v—(C6H4)—X3, —O—C(O)—NH—(CH2)v—(C6H4)—X3, —O—C(O)—O—(CH2)v—(C6H4)—X3,or NH—C(O)—CH2—(C6H4)—X3; Y1 and Y2 are each independently OH, C1-C4 alkyl, C1-C4 hydroxyalkyl, C1-C4 alkoxy, phenyl, benzyl, or NH2; R1 is C1-C4 alkyl; X1 and X2 are each independently halo or C1-C4 alkoxy; X3 is halo, nitro, C1-C4 alkyl, C1-C4 alkoxy, or C1-C4 perfluoroalkyl; Z is —C≡C—, —C6H4—, cis-CH═CH—, trans CH═CH—, cis-CH2—CH═CH—CH2—, trans —CH2—CH═CH—CH2—, 1, 4-naphthyl, cis-1,3-cyclohexyl, trans-1,
Type:
Application
Filed:
September 27, 2002
Publication date:
April 24, 2003
Inventors:
Dale L. Boger, David A. Cheresh