Copper Patents (Class 514/499)
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Patent number: 11925180Abstract: In an antimicrobial substrate, a cured material of a binder containing a copper compound and a polymerization initiator is fixed onto a surface of a base material. At least a part of the copper compound is exposed on a surface of the cured material of the binder.Type: GrantFiled: November 1, 2022Date of Patent: March 12, 2024Assignee: IBIDEN CO., LTD.Inventors: Katsutoshi Horino, Kozo Takada, Kazuhiro Ito, Kohei Otsuka, Kiyotaka Tsukada
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Patent number: 11517020Abstract: The present invention provides an antiviral substrate that is excellent in antiviral properties, is excellent in transparency or the like, and is capable of maintaining characteristics such as the transparency of a base material and the color of the surface of the base material. The present invention relates to an antiviral substrate in which a cured material of an electromagnetic curable resin containing a copper compound is scattered in the form of islands on a surface of a base material, and at least a part of the copper compound is exposed on a surface of the cured material of the electromagnetic curable resin.Type: GrantFiled: April 10, 2020Date of Patent: December 6, 2022Assignee: IBIDEN CO., LTD.Inventors: Katsutoshi Horino, Kozo Takada, Kazuhiro Ito, Kohei Otsuka, Kiyotaka Tsukada
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Patent number: 11167992Abstract: Provided is a method for preparing graphene by liquid-phase ball milling exfoliation, including following steps: mixing a transition metal halide salt, a nitrogen source substance and an organic solvent to prepare an intercalation agent; mixing the intercalation agent with graphite, carrying out ball milling, and then performing centrifugation to obtain a graphite intercalation compound; washing and filtering the graphite intercalation compound obtained, adding an expansion agent, and carrying out ultrasonic agitation to obtain a graphene dispersion; and washing, filtering and drying the graphene dispersion to obtain graphene powder.Type: GrantFiled: July 1, 2019Date of Patent: November 9, 2021Assignee: GUANGZHOU SPECIAL PRESSURE EQUIPMENT INSPECTION AND RESEARCH INSTITUTEInventors: Bo Yang, Shuanghong Zhang, Maodong Li, Wei Zhai, Fang Wen, Yue Li, Huachao Guo, Zhigang Wang, Guojia Huang, Shiping Li, Zhenling Wu, Yingyi He
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Patent number: 11091664Abstract: Water-based stains are based on an oil-in-water emulsion having a binder that includes, consists of, or consists essentially of drying oil combined with a non-aqueous polymer dispersion. The compositions can be tinted using traditional water-based pigment dispersions, yet the overall hydrophobicity results in minimal interaction with the polar cellulosic structure of wood.Type: GrantFiled: October 2, 2017Date of Patent: August 17, 2021Assignee: THE SHERWIN-WILLIAMS COMPANYInventor: Joshua Halstead
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Patent number: 10570022Abstract: A copper microparticle with antibacterial and/or biocidal activity, wherein each microparticle has a regular, crystalline and microstructured composition that comprises 5 different copper compounds: Antlerite Cu3+2 (SO4) (OH)4, Brochantite Cu4+2SO4 (OH)6, Chalcantite Cu+2SO4.5H2O, Natrochalcite NaCu2+2 (SO4)2OH.H2O and Hydrated copper sulfate hydroxide Cu3 (SO4)2 (OH)2.4H2O/2CuSO4.Cu (OH)2, with the microparticle having a size of between 5 and 50 ?m. A process for preparing copper microparticles with antibacterial and/or biocidal activity. A concentrated polymeric composition (masterbatch) with antibacterial and/or biocidal activity that is incorporated during the extrusion process to molten polymers for forming rigid or flexible products such as fibers, filaments, and sheets. A use of a copper microparticle with antibacterial and/or biocidal activity. A use of a concentrated polymeric composition (masterbatch) with antibacterial and/or biocidal activity.Type: GrantFiled: March 19, 2019Date of Patent: February 25, 2020Assignee: COPPERPROTEK SPAInventor: Javier Ignacio Lavin Carrasco
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Patent number: 9861704Abstract: Polymer/drug conjugates that can selectively target and kill cancer cells are described. Conjugates can include a copolymer formed by the reaction of a biocompatible hydrophilic component and a disulfiram derivative. The copolymer reaction product can include additional functional groups pendant to the backbone via a disulfide linkage, for instance copper chelators. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.Type: GrantFiled: December 8, 2015Date of Patent: January 9, 2018Assignee: University of South CarolinaInventors: Peisheng Xu, Huacheng He
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Patent number: 9034393Abstract: Bioactive agrichemical concentrates and compositions having improved bioactivity comprising combinations of acid solutions and conventional bioactive agrichemical actives or formulations.Type: GrantFiled: September 14, 2012Date of Patent: May 19, 2015Assignee: SCIESSENT LLCInventor: Joseph J. Crudden
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Patent number: 9017953Abstract: The present invention encompasses methods and compositions for detecting pathogenic bacteria. Additionally, the present invention encompasses methods and compositions for catalyzing the dismutation of superoxide radicals.Type: GrantFiled: May 20, 2013Date of Patent: April 28, 2015Assignee: Washington UniversityInventors: Jeffrey P. Henderson, Chia Hung, Kaveri Chaturvedi
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Publication number: 20150105461Abstract: The present invention relates to metal complexes, processes for their preparation and their use as pharmaceutical or veterinary agents, in particular for the treatment of conditions in which metal delivery can prevent, alleviate or ameliorate the condition. There are a number of clinical conditions which are caused by or associated with abnormal levels of metals (typically low metal levels). Conditions in of this type include cancer and conditions characterised by or associated with oxidative damage, more specifically neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease or Huntington's disease. The invention also relates to ligands useful in the preparation of metal complexes of this type.Type: ApplicationFiled: December 16, 2014Publication date: April 16, 2015Applicant: The University of MelbourneInventors: Kevin J. Barnham, Paul S. Donnelly, Anthony R. White
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Publication number: 20150057345Abstract: Method for improving the feed efficiency in poultry husbandry wherein poultry is provided with a compound directly upon hatching, the compound being selected from a lactylate in accordance with formula 1, or a Na, K, Ca, Mg, Fe(II), Zn, NH4, or Cu(II) salt thereof, R2-COO—[—CH(CH3)-COO]n-R1??Formula 1 a glycolylate of formula 2, or a Na, K, Ca, Mg, Fe(II), Zn, NH4, or Cu(II) salt thereof. R2-COO—[—CH2-COO]n-R1??Formula 2: a lactate ester of formula 3, HO—CH(CH3)-COO—R2??Formula 3: and/or a glycolic acid ester of formula 4, HO—CH2-COO—R2??Formula 4: In the above formulas R1 is selected from H, n stands for an integer with value of 1-10, and R2 stands for C1-C35 alkyl or alkenyl chain, which may be branched or unbranched. The effective compound provided to poultry is dosed level in a first part of their life-span higher than the dose level in other part of their life span.Type: ApplicationFiled: April 3, 2013Publication date: February 26, 2015Applicant: PURAC BIOCHEM BVInventors: Bart Jan Boomsma, Anne Cazemier
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Patent number: 8952057Abstract: Compositions containing polymetal complexes are useful in treating anorectal disorders.Type: GrantFiled: June 16, 2011Date of Patent: February 10, 2015Assignee: JR Chem, LLCInventor: José E. Ramirez
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Publication number: 20150038577Abstract: A nutritional supplement for a human, the supplement having a chelate comprised of an N-acetyl-L-cysteine ligand bonded to a metal to form a chelate ring. A method for preparing a chelate comprised of N-acetyl-L-cysteine ligand and a metal having the steps of: dissolving an amount of N-acetyl-L-cysteine in an aqueous solution, adding a metal to the aqueous solution, stifling and heating the aqueous solution, and removing the solvent under reduced pressure. A method of treating a human for one or more of oxidative stress, cardiovascular disease, cerebrovascular disease, neurodegenerative diseases, Alzheimer's disease, ADHD, bipolar, schizophrenia, autism, dementia, and HIV in a human comprising administering an effective amount of a composition having N-acetyl-L-cysteine in a chelate formation with a metal. A compound having a chelate formulation with a metal being chelated by an N-acetyl-L-cysteine ligand.Type: ApplicationFiled: December 27, 2013Publication date: February 5, 2015Inventors: Xueju Xie, Rhett Sean Daniels, Patricia Gahan
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Publication number: 20150031758Abstract: The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.Type: ApplicationFiled: August 8, 2014Publication date: January 29, 2015Inventors: Masazumi Nagai, Jianhua Shen
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Patent number: 8932644Abstract: The present disclosure is directed toward a composition and method of treating and preventing infection of pathogenic microorganisms and endopyhtic microorganisms in a plant through the use of phosphite compositions.Type: GrantFiled: July 1, 2014Date of Patent: January 13, 2015Inventor: Don M. Huber
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Publication number: 20140348880Abstract: A method for treating or preventing a microbial infection in a subject in need thereof, the method comprising administering to the subject, a therapeutically effective amount of a compound of Formula Ia, a compound of Formula IIa, one or more compounds of Formula Ia or Formula IIa complexed with a metal core, or a pharmaceutically acceptable salt, prodrug or hydrate thereof.Type: ApplicationFiled: May 23, 2014Publication date: November 27, 2014Inventors: Matthias Bierenstiel, Harshiny Muthukumar
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Patent number: 8889038Abstract: This invention relates to wood preservatives containing copper complexes and calcium ions, zinc ions or calcium and zinc ions for protection of wood, cellulose, hemicellulose, lignocellulose, cellulosic materials and articles derived from cellulosic materials from decay caused by fungi. The calcium ions, zinc ions, or calcium and zinc ions improve the penetration of copper preservative agent into the interior of a treated material or article.Type: GrantFiled: December 18, 2008Date of Patent: November 18, 2014Assignee: E I du Pont de Nemours and CompanyInventors: Albert Gordon Anderson, Mark A. Scialdone
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Publication number: 20140329014Abstract: The present invention relates to a composition for treating wood comprising a wood preserving compound and a carrier, wherein the carrier is an emulsion comprising a hydrophobic phase, a hydrophilic phase and a surfactant system. In particular, the surfactant system comprises a non-ionic polyethoxylated alkyl amine and an anionic C10-C16 alkylbenzene sulfonate. Methods of using the composition to treat wood, especially timber, are also described.Type: ApplicationFiled: May 2, 2014Publication date: November 6, 2014Applicant: DanIP Pty LtdInventor: Peter Raynor Soundy Cobham
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Publication number: 20140329892Abstract: Administration of a bis(thiohydrazide amide) compound is found to be surprisingly effective at treating subjects with cancer. Methods of treating a subject with cancer comprising continuously administering a bis(thiohydrazide amide) compound, or administering a bis(thiohydrazide amide) compound such that a constant concentration of the compound is achieved in the subject, are disclosed.Type: ApplicationFiled: November 9, 2012Publication date: November 6, 2014Applicant: SYNTA PHARMACEUTICALS CORP.Inventors: Jim Sang, Yumiko Wada
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Publication number: 20140303109Abstract: Water-soluble fluorinated analogs of natural curcumin, and particularly difluoro Knoevenagel condensates and Schiff bases, along with their corresponding copper (H) complexes have improved bioavailablity over curcumin. The fluorine-substituted analogs of curcumin are useful as chemopreventive and/or therapeutic agents against cancers and/or against the development of drug-resistant cancer. A preferred compound is (IE,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene{4(3,4 difluorobenzaldehyde)}-3,5-dione.Type: ApplicationFiled: March 25, 2011Publication date: October 9, 2014Inventors: Fazlul H. Sarkar, Subhash Padhye
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Publication number: 20140294989Abstract: The Cu- and Ti-containing composition of the present invention contains titanium oxide including rutile-crystal-type titanium oxide, and a divalent copper compound, wherein the rutile-crystal-type titanium oxide exhibits the most intense diffraction peak attributed to rutile-type titanium oxide having a full width at half maximum of 0.65° or less, in a Cu—K? line X-ray diffraction pattern, which is obtained by plotting intensity of diffraction line with respect to diffraction angle 2?. The composition exhibits excellent anti-viral property under light and in the dark, and excellent organic compound degradability under light.Type: ApplicationFiled: December 17, 2012Publication date: October 2, 2014Applicant: SHOWA DENKO K.K.Inventors: So Miyaishi, Yasushi Kuroka, Yasuhiro Hosogi, Ding Li
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Publication number: 20140271760Abstract: Described are antimicrobial liquid products comprising one or more antimicrobial organometallic additives dispersed throughout an organic host liquid.Type: ApplicationFiled: May 14, 2014Publication date: September 18, 2014Applicant: DMR INTERNATIONAL, INC.Inventors: MARC CHASON, DANIEL ROMAN GAMOTA, RICK LATELLA
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Publication number: 20140242404Abstract: The present invention relates to a wood preservative formulation comprising a biocidal agent which is a copper or zinc ion complexed with an amino compound selected from the group consisting of ammonia, a water soluble amine or alkanolamine and an aminocarboxylic acid and a stabilizer, as well as to aqueous treatment solutions comprising such a formulation and methods of treating wood or other cellulosic material utilising said formulation.Type: ApplicationFiled: May 2, 2014Publication date: August 28, 2014Applicant: ARCH TIMBER PROTECTION LIMITEDInventors: Kevin HUGHES, Craig Andrew MARS, Andrew HUGHES
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Publication number: 20140242137Abstract: Compositions and methods for use in treating, in particular, lignocellulosic substrates such as lumber, are provided; wherein said compositions comprise a preservative or biocidal species, other than boron, in the form of a glycolate. The methods may be used for the purpose of, for example, preventing the growth of pest organisms, or for providing other specific properties to the substrate.Type: ApplicationFiled: July 27, 2012Publication date: August 28, 2014Applicant: Matterworks One LimitedInventor: Nigel Paul Maynard
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Patent number: 8802725Abstract: The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.Type: GrantFiled: May 24, 2013Date of Patent: August 12, 2014Assignee: Synta Pharmaceuticals Corp.Inventors: Masazumi Nagai, Jianhua Shen
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Patent number: 8795736Abstract: The present disclosure is directed toward a composition and method of treating and preventing infection of pathogenic microorganisms and endopyhtic microorganisms in a plant through the use of phosphite compositions.Type: GrantFiled: December 15, 2009Date of Patent: August 5, 2014Inventor: Don M. Huber
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Publication number: 20140199356Abstract: Described are antimicrobial polymer products made from mixtures of antimicrobial organometallic additives dispersed throughout a polymer host matrix.Type: ApplicationFiled: March 15, 2013Publication date: July 17, 2014Inventors: MARC CHASON, Daniel Roman Gamota, Rick Latella
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Publication number: 20140199359Abstract: Described are antimicrobial polymer products made from mixtures of antimicrobial organometallic additives dispersed throughout a polymer host matrix.Type: ApplicationFiled: March 15, 2013Publication date: July 17, 2014Applicant: DMR INTERNATIONAL, INC.Inventors: MARC CHASON, DANIEL ROMAN GAMOTA, RICK LATELLA
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Publication number: 20140199358Abstract: Described are antimicrobial polymer products made from mixtures of antimicrobial organometallic additives dispersed throughout a polymer host matrix.Type: ApplicationFiled: March 15, 2013Publication date: July 17, 2014Applicant: DMR INTERNATIONAL, INC.Inventors: MARC CHASON, Daniel Roman Gamota, Rick Latella
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Publication number: 20140141096Abstract: The disclosure describes collagen constructs comprising antifungal agents, preferably, copper, and related methods.Type: ApplicationFiled: March 15, 2013Publication date: May 22, 2014Applicant: MiMedx Group, Inc.Inventor: MiMedx Group, Inc.
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Patent number: 8632811Abstract: A silica-based nanoformulation and method is used to treat citrus canker, inhibit the growth of mold and mildew, and add nutrients to soil used for agricultural purposes. The nanotechnology-enabled copper-loaded, silica nanoformulation (CuSiNP/NG) design is a “revolutionary re-invention” of Cu for safe application because it provides a formulation with maximum abundance of ionic Cu, provides sustained and optimal Cu ion release for long-term disease protection, better adherence to plant surfaces and structural surfaces due to gel-based nanostructure of CuSiNG, thus avoiding multiple spray applications and reducing the amount of Cu used in comparison to existing Cu compounds without compromising antibacterial activity.Type: GrantFiled: June 20, 2012Date of Patent: January 21, 2014Assignee: University of Central Florida Research Foundation, Inc.Inventor: Swadeshmukul Santra
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Publication number: 20140011864Abstract: The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.Type: ApplicationFiled: May 24, 2013Publication date: January 9, 2014Inventors: Masazumi Nagai, Jianhua Shen
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Publication number: 20140004265Abstract: This invention relates to wood preservatives containing copper complexes that significantly reduce the decay of wood, cellulose, hemicellulose, and lignin caused by fungi and insects. The copper complexes include a chelating compound that has amide functional groups derived from hydration of a cyanoethylated compound or carboxylic acid functional groups derived from hydrolysis of a cyanoethylated compound, or both types of groups.Type: ApplicationFiled: September 3, 2013Publication date: January 2, 2014Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: ALBERT GORDON ANDERSON, MARK A. SCIALDONE
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Publication number: 20130344167Abstract: The present invention relates to a galenic composition suitable for administration to a non-human animal, including at least the following three components: one or more active principles; an agent for accelerating delitescence; an agent for delaying delitescence, wherein the agent for accelerating delitescence an the agent for delaying delitescence are integrated in the composition so as to form a matrix with the controlled release of the active principle(s). The invention also relates to the uses of said compositions, as well as to a method for measuring the in vitro delitescence thereof.Type: ApplicationFiled: November 27, 2011Publication date: December 26, 2013Applicant: VETALIS SARLInventors: Laurent Chery, Jean-Pierre Wajda-Dubos
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Publication number: 20130324598Abstract: Provided herein are methods of treating a subject with a mycobacterial infection. The methods comprise administering to the subject a Cu+/++ boosting therapeutic. Also provided are compositions comprising a Cu+/++ boosting therapeutic. Further provided are methods of screening for a Cu+/++ boosting therapeutic.Type: ApplicationFiled: February 17, 2012Publication date: December 5, 2013Applicant: THE UAB RESEARCH FOUNDATIONInventors: Olaf Kutsch, Frank Wolschendorf
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Publication number: 20130289108Abstract: A palladium-copper catalyst of homogeneous selective oxidation of thiols is proposed, combining a functional binuclear thiolate-bridged coordination compound of palladium (II) and a modifying thiolate complex of copper (I), having the general formula [Pd2II(?-SR)2(NH3)4]·{CukI(SR)m}??(I), where SR is the residue of a thiolate ligand, chosen from the group including a residue of glutathione and acetylcysteine, k=2 to 14, m?3k. Also proposed are a catalytic combination, a pharmacological combination, a pharmaceutical composition, and a method of therapeutic action on a patient's organism based on the indicated catalyst.Type: ApplicationFiled: December 30, 2011Publication date: October 31, 2013Applicant: "Ivy Pharm" Limited Liability CompanyInventors: Mark Borisovich Balazovsky, Viktor Georgievich Antonov, Alexandr Nikolaevich Belyaev, Alexei Vladimirovich Eremin
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Patent number: 8568759Abstract: The present invention provides an environmentally compatible, pesticidal composition and method for the control of insect pests. The composition includes two components. The first component is a chelating agent, a metal complex of a chelating agent, and mixtures thereof, and the second component is preferably a carrier material.Type: GrantFiled: December 14, 2010Date of Patent: October 29, 2013Assignee: W. Neudorff GmbH KGInventor: Diana L. Parker
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Publication number: 20130267483Abstract: This invention relates to complexes of certain divalent and polyvalent d-orbital metals of first transition series of the Periodic Table of Elements, from Group IV to Group VI, and including molybdenum, having a hydroxy acid [HA] and an amino acid [AA] moiety concurrently bound to a single said metal and having a spirocyclic, bidentate chelate structure of formula (I). Upon topical application said metal complexes undergo enhanced skin penetration without causing skin irritation.Type: ApplicationFiled: February 6, 2013Publication date: October 10, 2013Applicant: BIODERM RESEARCHInventor: SHYAM K GUPTA
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Patent number: 8529951Abstract: Disclosed are elastogenic cues that can be utilized to encourage growth and development of elastin-containing cellular constructs. The elastogenic cues include hyaluronan fragments and oligomers, optionally in conjunction with growth factors and/or a source of copper ions. The elastogenic cues can up-regulate elastin matrix synthesis and by vascular smooth muscle cells. In addition to encouraging synthesis of elastin in a cellular matrix and organization into elastic fibers, the elastogenic cues can also stabilize the formed ECM matrix through suppression of elastin-laminin receptor (ELR). In addition, the elastogenic cues can inhibit cell hyper-proliferation (e.g., hyperplasia) common in inflammatory vascular disease.Type: GrantFiled: February 20, 2008Date of Patent: September 10, 2013Inventors: Anand Ramamurthi, Chandrasekhar Kothapalli, Binata Joddar
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Patent number: 8513303Abstract: The present invention provides a method of killing and/or inactivating microbes, the method comprising the step of placing the microbes in contact with a catalyst by means of a fluid medium, wherein the catalyst comprises a solid support, which solid support comprises one or more fibers, and a first metal cation fixed to the support. The fibers are keratinous fibers like wool fibers, or polyacrylonitrile (PAN) fibers. The first metal cation is selected from transition metal copper, silver and gold included. A second non-transition metal cation can be present. The catalyst is prepared by first treating the fibers with hydrazine and/or hydroxylamine salt in presence of a base, the modified fibers are then treated with an aqueous solution of containing the metal cations.Type: GrantFiled: August 22, 2008Date of Patent: August 20, 2013Assignee: De Montfort UniversityInventors: Katherine Huddersman, Susannah Elizabeth Walsh
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Patent number: 8461199Abstract: The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.Type: GrantFiled: October 21, 2009Date of Patent: June 11, 2013Assignee: Synta Pharmaceuticals Corp.Inventors: Nagai Masazumi, Jianhua Shen
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Publication number: 20130096090Abstract: The present invention relates to the fields of chemistry and pharmaceuticals. Embodiments of the present invention provide transition metal complexes of amino acids. Transition metal complexes of embodiments of the invention according to Categories I, II, III, and/or IV may be used as antimicrobial, anti-malarial, and anti-cancer agents, as well as catalysts in chemical reactions. Such compounds of the invention are particularly useful for combating multi-drug resistance against a broad range of microbials (such as MRSA and mycobacteria), including gram positive and gram negative bacteria, as well as can be used as anti-cancer agents against bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, leukemia, lung cancer, melanoma, non-Hodgkin's lymphoma, pancreatic cancer, prostate cancer, and thyroid cancer, to name a few.Type: ApplicationFiled: October 17, 2012Publication date: April 18, 2013Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.Inventor: Virginia Tech Intellectual Properties, Inc.
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Publication number: 20130096069Abstract: This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including into and across ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidino or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length.Type: ApplicationFiled: September 10, 2012Publication date: April 18, 2013Inventors: Jonathan B. Rothbard, Paul A. Wender, P. Leo McGrane, Lalitha V.S. Sista, Thorsten A. Kirschberg
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Patent number: 8414931Abstract: Disclosed is a wood preservative composition comprising micronized copper and copper-amine complex, wherein the copper component of the copper amine complex is from about 5% to about 50% by weight, based upon the total weight of copper in the composition. The copper amine complex serves to avoid wood surface “chalking” that is otherwise attributable to the presence of micronized copper in copper-based slurries used to treat wood products. In addition, the copper-amine complex enhances the antimicrobial efficacy of the composition when used in wood treatment applications by facilitating cell wall penetration of the treated wood.Type: GrantFiled: September 13, 2012Date of Patent: April 9, 2013Assignee: Arch Wood Protection, Inc.Inventor: Jayesh P. Patel
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Patent number: 8377482Abstract: The invention discloses a trace element solution, which comprises at least one metal selected from the group comprising selenium, copper, zinc, manganese and chromium; and at least one component selected from the group comprising a vitamin, a vaccine, a growth stimulant, a dewormer, iron dextran, an antibiotic and a synchronization preparation. The synchronization preparation is a combination of injectable hormonal preparations, inplantable hormonal preparations, intravaginal hormonal preparation and other slow release hormonal preparation. The antibiotics include oral, injectable and implantable theurapeutic remedies. The vaccine includes antigens and a combination of antigens and adjuvents. The growth stimulants include zeranol, estradiol, testosterone, progesterone and trenbolone acetate. The dewormer includes macrocydic lactones, leramizoles, benzimidazoles and salicylanilides. The macrocydic lactones include doramectin, ivermectin, abamectin and moxidectin.Type: GrantFiled: September 7, 2005Date of Patent: February 19, 2013Assignee: Warburton Technology LimitedInventors: Robert N. Laurie, William A. Smith
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Publication number: 20130035386Abstract: Certain bis[thio-hydrazide amide]-related compounds are found to be surprisingly effective at treating with leukemia, e.g., acute myeloid leukemia (AML). Methods of treating a subject with AML including administering bis[thio-hydrazide amide]-related compounds described herein, are disclosed.Type: ApplicationFiled: December 6, 2010Publication date: February 7, 2013Applicant: SYNTA PHARMACEUTICALS CORP.Inventors: Masazumi Nagai, Jianhua Shen
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Publication number: 20130004589Abstract: Compositions and methods for treating and/or preventing conditions such as diaper rash and atopic dermatitis are disclosed. The compositions and methods are particularly useful in the treatment and prevention of diaper rash and diaper dermatitis caused by the prolonged contact of human skin with body waste. The methods employ the topical application of a trypsin-inhibiting agent to the area in need of such treatment, or the area where prevention is desired. The trypsin-inhibiting agent is preferably a divalent cation/anion pair.Type: ApplicationFiled: June 28, 2011Publication date: January 3, 2013Inventors: Connie B. Lin, Euen Thomas Graham Ekman Gunn, Ya-Ping Hu, Neema Kulkarni, Mary Catherine Mack
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Publication number: 20130004587Abstract: Bioactive agrichemical concentrates and compositions having improved bioactivity comprising combinations of acid solutions and conventional bioactive agrichemical actives or formulations.Type: ApplicationFiled: September 14, 2012Publication date: January 3, 2013Applicant: SCIESSENT LLCInventor: Joseph J. Crudden
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Publication number: 20120301530Abstract: Embodiments of the invention are directed to a composition having antimicrobial activity comprising particles comprising at least one inorganic copper salt; and at least one functionalizing agent in contact with the particles, the functionalizing agent stabilizing the particle in a carrier such that an antimicrobially effective amount of ions are released into the environment of a microbe. The average size of the particles ranges from about 1000 nm to about 4 nm. Preferred copper salts include copper iodide, copper bromide and copper chloride. Preferred functionalizing agents include amino acids, thiols, hydrophilic polymers emulsions of hydrophobic polymers and surfactants.Type: ApplicationFiled: June 14, 2012Publication date: November 29, 2012Inventors: Donald R. Uhlmann, Anoop Agrawal, Murat Akarsu, John P. Cronin
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Patent number: 8299285Abstract: A metal complex of formula (III) wherein: M is a transition metal and A1, A2, X, X?, Y, L1?, R1? and R2? are as defined herein, is useful in medical imaging and therapy.Type: GrantFiled: July 5, 2006Date of Patent: October 30, 2012Assignee: Isis Innovation LimitedInventors: Jonathan Robin Dilworth, Josephine Mary Peach, Julia May Heslop, Paul Stephen Donnelly
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Publication number: 20120270850Abstract: The present invention relates to metal complexes, processes for their preparation and their use as pharmaceutical or veterinary agents, in particular for the treatment of conditions in which metal delivery can prevent, alleviate or ameliorate the condition. There are a number of clinical conditions which are caused by or associated with abnormal levels of metals (typically low metal levels). Conditions in of this type include cancer and conditions characterised by or associated with oxidative damage, more specifically neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease or Huntington's disease. The invention also relates to ligands useful in the preparation of metal complexes of this type.Type: ApplicationFiled: November 20, 2007Publication date: October 25, 2012Applicant: UNIVERSITY OF MEDLBOURNEInventors: Kevin Jeffrey Barnham, Paul Stephen Donnelly, Anthony Robert White