Copper Patents (Class 514/499)
  • Patent number: 9861704
    Abstract: Polymer/drug conjugates that can selectively target and kill cancer cells are described. Conjugates can include a copolymer formed by the reaction of a biocompatible hydrophilic component and a disulfiram derivative. The copolymer reaction product can include additional functional groups pendant to the backbone via a disulfide linkage, for instance copper chelators. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: January 9, 2018
    Assignee: University of South Carolina
    Inventors: Peisheng Xu, Huacheng He
  • Patent number: 9034393
    Abstract: Bioactive agrichemical concentrates and compositions having improved bioactivity comprising combinations of acid solutions and conventional bioactive agrichemical actives or formulations.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: May 19, 2015
    Assignee: SCIESSENT LLC
    Inventor: Joseph J. Crudden
  • Patent number: 9017953
    Abstract: The present invention encompasses methods and compositions for detecting pathogenic bacteria. Additionally, the present invention encompasses methods and compositions for catalyzing the dismutation of superoxide radicals.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: April 28, 2015
    Assignee: Washington University
    Inventors: Jeffrey P. Henderson, Chia Hung, Kaveri Chaturvedi
  • Publication number: 20150105461
    Abstract: The present invention relates to metal complexes, processes for their preparation and their use as pharmaceutical or veterinary agents, in particular for the treatment of conditions in which metal delivery can prevent, alleviate or ameliorate the condition. There are a number of clinical conditions which are caused by or associated with abnormal levels of metals (typically low metal levels). Conditions in of this type include cancer and conditions characterised by or associated with oxidative damage, more specifically neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease or Huntington's disease. The invention also relates to ligands useful in the preparation of metal complexes of this type.
    Type: Application
    Filed: December 16, 2014
    Publication date: April 16, 2015
    Applicant: The University of Melbourne
    Inventors: Kevin J. Barnham, Paul S. Donnelly, Anthony R. White
  • Publication number: 20150057345
    Abstract: Method for improving the feed efficiency in poultry husbandry wherein poultry is provided with a compound directly upon hatching, the compound being selected from a lactylate in accordance with formula 1, or a Na, K, Ca, Mg, Fe(II), Zn, NH4, or Cu(II) salt thereof, R2-COO—[—CH(CH3)-COO]n-R1??Formula 1 a glycolylate of formula 2, or a Na, K, Ca, Mg, Fe(II), Zn, NH4, or Cu(II) salt thereof. R2-COO—[—CH2-COO]n-R1??Formula 2: a lactate ester of formula 3, HO—CH(CH3)-COO—R2??Formula 3: and/or a glycolic acid ester of formula 4, HO—CH2-COO—R2??Formula 4: In the above formulas R1 is selected from H, n stands for an integer with value of 1-10, and R2 stands for C1-C35 alkyl or alkenyl chain, which may be branched or unbranched. The effective compound provided to poultry is dosed level in a first part of their life-span higher than the dose level in other part of their life span.
    Type: Application
    Filed: April 3, 2013
    Publication date: February 26, 2015
    Applicant: PURAC BIOCHEM BV
    Inventors: Bart Jan Boomsma, Anne Cazemier
  • Patent number: 8952057
    Abstract: Compositions containing polymetal complexes are useful in treating anorectal disorders.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: February 10, 2015
    Assignee: JR Chem, LLC
    Inventor: José E. Ramirez
  • Publication number: 20150038577
    Abstract: A nutritional supplement for a human, the supplement having a chelate comprised of an N-acetyl-L-cysteine ligand bonded to a metal to form a chelate ring. A method for preparing a chelate comprised of N-acetyl-L-cysteine ligand and a metal having the steps of: dissolving an amount of N-acetyl-L-cysteine in an aqueous solution, adding a metal to the aqueous solution, stifling and heating the aqueous solution, and removing the solvent under reduced pressure. A method of treating a human for one or more of oxidative stress, cardiovascular disease, cerebrovascular disease, neurodegenerative diseases, Alzheimer's disease, ADHD, bipolar, schizophrenia, autism, dementia, and HIV in a human comprising administering an effective amount of a composition having N-acetyl-L-cysteine in a chelate formation with a metal. A compound having a chelate formulation with a metal being chelated by an N-acetyl-L-cysteine ligand.
    Type: Application
    Filed: December 27, 2013
    Publication date: February 5, 2015
    Inventors: Xueju Xie, Rhett Sean Daniels, Patricia Gahan
  • Publication number: 20150031758
    Abstract: The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.
    Type: Application
    Filed: August 8, 2014
    Publication date: January 29, 2015
    Inventors: Masazumi Nagai, Jianhua Shen
  • Patent number: 8932644
    Abstract: The present disclosure is directed toward a composition and method of treating and preventing infection of pathogenic microorganisms and endopyhtic microorganisms in a plant through the use of phosphite compositions.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: January 13, 2015
    Inventor: Don M. Huber
  • Publication number: 20140348880
    Abstract: A method for treating or preventing a microbial infection in a subject in need thereof, the method comprising administering to the subject, a therapeutically effective amount of a compound of Formula Ia, a compound of Formula IIa, one or more compounds of Formula Ia or Formula IIa complexed with a metal core, or a pharmaceutically acceptable salt, prodrug or hydrate thereof.
    Type: Application
    Filed: May 23, 2014
    Publication date: November 27, 2014
    Inventors: Matthias Bierenstiel, Harshiny Muthukumar
  • Patent number: 8889038
    Abstract: This invention relates to wood preservatives containing copper complexes and calcium ions, zinc ions or calcium and zinc ions for protection of wood, cellulose, hemicellulose, lignocellulose, cellulosic materials and articles derived from cellulosic materials from decay caused by fungi. The calcium ions, zinc ions, or calcium and zinc ions improve the penetration of copper preservative agent into the interior of a treated material or article.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: November 18, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Albert Gordon Anderson, Mark A. Scialdone
  • Publication number: 20140329014
    Abstract: The present invention relates to a composition for treating wood comprising a wood preserving compound and a carrier, wherein the carrier is an emulsion comprising a hydrophobic phase, a hydrophilic phase and a surfactant system. In particular, the surfactant system comprises a non-ionic polyethoxylated alkyl amine and an anionic C10-C16 alkylbenzene sulfonate. Methods of using the composition to treat wood, especially timber, are also described.
    Type: Application
    Filed: May 2, 2014
    Publication date: November 6, 2014
    Applicant: DanIP Pty Ltd
    Inventor: Peter Raynor Soundy Cobham
  • Publication number: 20140329892
    Abstract: Administration of a bis(thiohydrazide amide) compound is found to be surprisingly effective at treating subjects with cancer. Methods of treating a subject with cancer comprising continuously administering a bis(thiohydrazide amide) compound, or administering a bis(thiohydrazide amide) compound such that a constant concentration of the compound is achieved in the subject, are disclosed.
    Type: Application
    Filed: November 9, 2012
    Publication date: November 6, 2014
    Applicant: SYNTA PHARMACEUTICALS CORP.
    Inventors: Jim Sang, Yumiko Wada
  • Publication number: 20140303109
    Abstract: Water-soluble fluorinated analogs of natural curcumin, and particularly difluoro Knoevenagel condensates and Schiff bases, along with their corresponding copper (H) complexes have improved bioavailablity over curcumin. The fluorine-substituted analogs of curcumin are useful as chemopreventive and/or therapeutic agents against cancers and/or against the development of drug-resistant cancer. A preferred compound is (IE,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene{4(3,4 difluorobenzaldehyde)}-3,5-dione.
    Type: Application
    Filed: March 25, 2011
    Publication date: October 9, 2014
    Inventors: Fazlul H. Sarkar, Subhash Padhye
  • Publication number: 20140294989
    Abstract: The Cu- and Ti-containing composition of the present invention contains titanium oxide including rutile-crystal-type titanium oxide, and a divalent copper compound, wherein the rutile-crystal-type titanium oxide exhibits the most intense diffraction peak attributed to rutile-type titanium oxide having a full width at half maximum of 0.65° or less, in a Cu—K? line X-ray diffraction pattern, which is obtained by plotting intensity of diffraction line with respect to diffraction angle 2?. The composition exhibits excellent anti-viral property under light and in the dark, and excellent organic compound degradability under light.
    Type: Application
    Filed: December 17, 2012
    Publication date: October 2, 2014
    Applicant: SHOWA DENKO K.K.
    Inventors: So Miyaishi, Yasushi Kuroka, Yasuhiro Hosogi, Ding Li
  • Publication number: 20140271760
    Abstract: Described are antimicrobial liquid products comprising one or more antimicrobial organometallic additives dispersed throughout an organic host liquid.
    Type: Application
    Filed: May 14, 2014
    Publication date: September 18, 2014
    Applicant: DMR INTERNATIONAL, INC.
    Inventors: MARC CHASON, DANIEL ROMAN GAMOTA, RICK LATELLA
  • Publication number: 20140242137
    Abstract: Compositions and methods for use in treating, in particular, lignocellulosic substrates such as lumber, are provided; wherein said compositions comprise a preservative or biocidal species, other than boron, in the form of a glycolate. The methods may be used for the purpose of, for example, preventing the growth of pest organisms, or for providing other specific properties to the substrate.
    Type: Application
    Filed: July 27, 2012
    Publication date: August 28, 2014
    Applicant: Matterworks One Limited
    Inventor: Nigel Paul Maynard
  • Publication number: 20140242404
    Abstract: The present invention relates to a wood preservative formulation comprising a biocidal agent which is a copper or zinc ion complexed with an amino compound selected from the group consisting of ammonia, a water soluble amine or alkanolamine and an aminocarboxylic acid and a stabilizer, as well as to aqueous treatment solutions comprising such a formulation and methods of treating wood or other cellulosic material utilising said formulation.
    Type: Application
    Filed: May 2, 2014
    Publication date: August 28, 2014
    Applicant: ARCH TIMBER PROTECTION LIMITED
    Inventors: Kevin HUGHES, Craig Andrew MARS, Andrew HUGHES
  • Patent number: 8802725
    Abstract: The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: August 12, 2014
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Masazumi Nagai, Jianhua Shen
  • Patent number: 8795736
    Abstract: The present disclosure is directed toward a composition and method of treating and preventing infection of pathogenic microorganisms and endopyhtic microorganisms in a plant through the use of phosphite compositions.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: August 5, 2014
    Inventor: Don M. Huber
  • Publication number: 20140199356
    Abstract: Described are antimicrobial polymer products made from mixtures of antimicrobial organometallic additives dispersed throughout a polymer host matrix.
    Type: Application
    Filed: March 15, 2013
    Publication date: July 17, 2014
    Inventors: MARC CHASON, Daniel Roman Gamota, Rick Latella
  • Publication number: 20140199359
    Abstract: Described are antimicrobial polymer products made from mixtures of antimicrobial organometallic additives dispersed throughout a polymer host matrix.
    Type: Application
    Filed: March 15, 2013
    Publication date: July 17, 2014
    Applicant: DMR INTERNATIONAL, INC.
    Inventors: MARC CHASON, DANIEL ROMAN GAMOTA, RICK LATELLA
  • Publication number: 20140199358
    Abstract: Described are antimicrobial polymer products made from mixtures of antimicrobial organometallic additives dispersed throughout a polymer host matrix.
    Type: Application
    Filed: March 15, 2013
    Publication date: July 17, 2014
    Applicant: DMR INTERNATIONAL, INC.
    Inventors: MARC CHASON, Daniel Roman Gamota, Rick Latella
  • Publication number: 20140141096
    Abstract: The disclosure describes collagen constructs comprising antifungal agents, preferably, copper, and related methods.
    Type: Application
    Filed: March 15, 2013
    Publication date: May 22, 2014
    Applicant: MiMedx Group, Inc.
    Inventor: MiMedx Group, Inc.
  • Patent number: 8632811
    Abstract: A silica-based nanoformulation and method is used to treat citrus canker, inhibit the growth of mold and mildew, and add nutrients to soil used for agricultural purposes. The nanotechnology-enabled copper-loaded, silica nanoformulation (CuSiNP/NG) design is a “revolutionary re-invention” of Cu for safe application because it provides a formulation with maximum abundance of ionic Cu, provides sustained and optimal Cu ion release for long-term disease protection, better adherence to plant surfaces and structural surfaces due to gel-based nanostructure of CuSiNG, thus avoiding multiple spray applications and reducing the amount of Cu used in comparison to existing Cu compounds without compromising antibacterial activity.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: January 21, 2014
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Swadeshmukul Santra
  • Publication number: 20140011864
    Abstract: The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.
    Type: Application
    Filed: May 24, 2013
    Publication date: January 9, 2014
    Inventors: Masazumi Nagai, Jianhua Shen
  • Publication number: 20140004265
    Abstract: This invention relates to wood preservatives containing copper complexes that significantly reduce the decay of wood, cellulose, hemicellulose, and lignin caused by fungi and insects. The copper complexes include a chelating compound that has amide functional groups derived from hydration of a cyanoethylated compound or carboxylic acid functional groups derived from hydrolysis of a cyanoethylated compound, or both types of groups.
    Type: Application
    Filed: September 3, 2013
    Publication date: January 2, 2014
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: ALBERT GORDON ANDERSON, MARK A. SCIALDONE
  • Publication number: 20130344167
    Abstract: The present invention relates to a galenic composition suitable for administration to a non-human animal, including at least the following three components: one or more active principles; an agent for accelerating delitescence; an agent for delaying delitescence, wherein the agent for accelerating delitescence an the agent for delaying delitescence are integrated in the composition so as to form a matrix with the controlled release of the active principle(s). The invention also relates to the uses of said compositions, as well as to a method for measuring the in vitro delitescence thereof.
    Type: Application
    Filed: November 27, 2011
    Publication date: December 26, 2013
    Applicant: VETALIS SARL
    Inventors: Laurent Chery, Jean-Pierre Wajda-Dubos
  • Publication number: 20130324598
    Abstract: Provided herein are methods of treating a subject with a mycobacterial infection. The methods comprise administering to the subject a Cu+/++ boosting therapeutic. Also provided are compositions comprising a Cu+/++ boosting therapeutic. Further provided are methods of screening for a Cu+/++ boosting therapeutic.
    Type: Application
    Filed: February 17, 2012
    Publication date: December 5, 2013
    Applicant: THE UAB RESEARCH FOUNDATION
    Inventors: Olaf Kutsch, Frank Wolschendorf
  • Publication number: 20130289108
    Abstract: A palladium-copper catalyst of homogeneous selective oxidation of thiols is proposed, combining a functional binuclear thiolate-bridged coordination compound of palladium (II) and a modifying thiolate complex of copper (I), having the general formula [Pd2II(?-SR)2(NH3)4]·{CukI(SR)m}??(I), where SR is the residue of a thiolate ligand, chosen from the group including a residue of glutathione and acetylcysteine, k=2 to 14, m?3k. Also proposed are a catalytic combination, a pharmacological combination, a pharmaceutical composition, and a method of therapeutic action on a patient's organism based on the indicated catalyst.
    Type: Application
    Filed: December 30, 2011
    Publication date: October 31, 2013
    Applicant: "Ivy Pharm" Limited Liability Company
    Inventors: Mark Borisovich Balazovsky, Viktor Georgievich Antonov, Alexandr Nikolaevich Belyaev, Alexei Vladimirovich Eremin
  • Patent number: 8568759
    Abstract: The present invention provides an environmentally compatible, pesticidal composition and method for the control of insect pests. The composition includes two components. The first component is a chelating agent, a metal complex of a chelating agent, and mixtures thereof, and the second component is preferably a carrier material.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: October 29, 2013
    Assignee: W. Neudorff GmbH KG
    Inventor: Diana L. Parker
  • Publication number: 20130267483
    Abstract: This invention relates to complexes of certain divalent and polyvalent d-orbital metals of first transition series of the Periodic Table of Elements, from Group IV to Group VI, and including molybdenum, having a hydroxy acid [HA] and an amino acid [AA] moiety concurrently bound to a single said metal and having a spirocyclic, bidentate chelate structure of formula (I). Upon topical application said metal complexes undergo enhanced skin penetration without causing skin irritation.
    Type: Application
    Filed: February 6, 2013
    Publication date: October 10, 2013
    Applicant: BIODERM RESEARCH
    Inventor: SHYAM K GUPTA
  • Patent number: 8529951
    Abstract: Disclosed are elastogenic cues that can be utilized to encourage growth and development of elastin-containing cellular constructs. The elastogenic cues include hyaluronan fragments and oligomers, optionally in conjunction with growth factors and/or a source of copper ions. The elastogenic cues can up-regulate elastin matrix synthesis and by vascular smooth muscle cells. In addition to encouraging synthesis of elastin in a cellular matrix and organization into elastic fibers, the elastogenic cues can also stabilize the formed ECM matrix through suppression of elastin-laminin receptor (ELR). In addition, the elastogenic cues can inhibit cell hyper-proliferation (e.g., hyperplasia) common in inflammatory vascular disease.
    Type: Grant
    Filed: February 20, 2008
    Date of Patent: September 10, 2013
    Inventors: Anand Ramamurthi, Chandrasekhar Kothapalli, Binata Joddar
  • Patent number: 8513303
    Abstract: The present invention provides a method of killing and/or inactivating microbes, the method comprising the step of placing the microbes in contact with a catalyst by means of a fluid medium, wherein the catalyst comprises a solid support, which solid support comprises one or more fibers, and a first metal cation fixed to the support. The fibers are keratinous fibers like wool fibers, or polyacrylonitrile (PAN) fibers. The first metal cation is selected from transition metal copper, silver and gold included. A second non-transition metal cation can be present. The catalyst is prepared by first treating the fibers with hydrazine and/or hydroxylamine salt in presence of a base, the modified fibers are then treated with an aqueous solution of containing the metal cations.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: August 20, 2013
    Assignee: De Montfort University
    Inventors: Katherine Huddersman, Susannah Elizabeth Walsh
  • Patent number: 8461199
    Abstract: The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: June 11, 2013
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Nagai Masazumi, Jianhua Shen
  • Publication number: 20130096090
    Abstract: The present invention relates to the fields of chemistry and pharmaceuticals. Embodiments of the present invention provide transition metal complexes of amino acids. Transition metal complexes of embodiments of the invention according to Categories I, II, III, and/or IV may be used as antimicrobial, anti-malarial, and anti-cancer agents, as well as catalysts in chemical reactions. Such compounds of the invention are particularly useful for combating multi-drug resistance against a broad range of microbials (such as MRSA and mycobacteria), including gram positive and gram negative bacteria, as well as can be used as anti-cancer agents against bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, leukemia, lung cancer, melanoma, non-Hodgkin's lymphoma, pancreatic cancer, prostate cancer, and thyroid cancer, to name a few.
    Type: Application
    Filed: October 17, 2012
    Publication date: April 18, 2013
    Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
    Inventor: Virginia Tech Intellectual Properties, Inc.
  • Publication number: 20130096069
    Abstract: This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including into and across ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidino or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length.
    Type: Application
    Filed: September 10, 2012
    Publication date: April 18, 2013
    Inventors: Jonathan B. Rothbard, Paul A. Wender, P. Leo McGrane, Lalitha V.S. Sista, Thorsten A. Kirschberg
  • Patent number: 8414931
    Abstract: Disclosed is a wood preservative composition comprising micronized copper and copper-amine complex, wherein the copper component of the copper amine complex is from about 5% to about 50% by weight, based upon the total weight of copper in the composition. The copper amine complex serves to avoid wood surface “chalking” that is otherwise attributable to the presence of micronized copper in copper-based slurries used to treat wood products. In addition, the copper-amine complex enhances the antimicrobial efficacy of the composition when used in wood treatment applications by facilitating cell wall penetration of the treated wood.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: April 9, 2013
    Assignee: Arch Wood Protection, Inc.
    Inventor: Jayesh P. Patel
  • Patent number: 8377482
    Abstract: The invention discloses a trace element solution, which comprises at least one metal selected from the group comprising selenium, copper, zinc, manganese and chromium; and at least one component selected from the group comprising a vitamin, a vaccine, a growth stimulant, a dewormer, iron dextran, an antibiotic and a synchronization preparation. The synchronization preparation is a combination of injectable hormonal preparations, inplantable hormonal preparations, intravaginal hormonal preparation and other slow release hormonal preparation. The antibiotics include oral, injectable and implantable theurapeutic remedies. The vaccine includes antigens and a combination of antigens and adjuvents. The growth stimulants include zeranol, estradiol, testosterone, progesterone and trenbolone acetate. The dewormer includes macrocydic lactones, leramizoles, benzimidazoles and salicylanilides. The macrocydic lactones include doramectin, ivermectin, abamectin and moxidectin.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: February 19, 2013
    Assignee: Warburton Technology Limited
    Inventors: Robert N. Laurie, William A. Smith
  • Publication number: 20130035386
    Abstract: Certain bis[thio-hydrazide amide]-related compounds are found to be surprisingly effective at treating with leukemia, e.g., acute myeloid leukemia (AML). Methods of treating a subject with AML including administering bis[thio-hydrazide amide]-related compounds described herein, are disclosed.
    Type: Application
    Filed: December 6, 2010
    Publication date: February 7, 2013
    Applicant: SYNTA PHARMACEUTICALS CORP.
    Inventors: Masazumi Nagai, Jianhua Shen
  • Publication number: 20130004589
    Abstract: Compositions and methods for treating and/or preventing conditions such as diaper rash and atopic dermatitis are disclosed. The compositions and methods are particularly useful in the treatment and prevention of diaper rash and diaper dermatitis caused by the prolonged contact of human skin with body waste. The methods employ the topical application of a trypsin-inhibiting agent to the area in need of such treatment, or the area where prevention is desired. The trypsin-inhibiting agent is preferably a divalent cation/anion pair.
    Type: Application
    Filed: June 28, 2011
    Publication date: January 3, 2013
    Inventors: Connie B. Lin, Euen Thomas Graham Ekman Gunn, Ya-Ping Hu, Neema Kulkarni, Mary Catherine Mack
  • Publication number: 20130004587
    Abstract: Bioactive agrichemical concentrates and compositions having improved bioactivity comprising combinations of acid solutions and conventional bioactive agrichemical actives or formulations.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 3, 2013
    Applicant: SCIESSENT LLC
    Inventor: Joseph J. Crudden
  • Publication number: 20120301530
    Abstract: Embodiments of the invention are directed to a composition having antimicrobial activity comprising particles comprising at least one inorganic copper salt; and at least one functionalizing agent in contact with the particles, the functionalizing agent stabilizing the particle in a carrier such that an antimicrobially effective amount of ions are released into the environment of a microbe. The average size of the particles ranges from about 1000 nm to about 4 nm. Preferred copper salts include copper iodide, copper bromide and copper chloride. Preferred functionalizing agents include amino acids, thiols, hydrophilic polymers emulsions of hydrophobic polymers and surfactants.
    Type: Application
    Filed: June 14, 2012
    Publication date: November 29, 2012
    Inventors: Donald R. Uhlmann, Anoop Agrawal, Murat Akarsu, John P. Cronin
  • Patent number: 8299285
    Abstract: A metal complex of formula (III) wherein: M is a transition metal and A1, A2, X, X?, Y, L1?, R1? and R2? are as defined herein, is useful in medical imaging and therapy.
    Type: Grant
    Filed: July 5, 2006
    Date of Patent: October 30, 2012
    Assignee: Isis Innovation Limited
    Inventors: Jonathan Robin Dilworth, Josephine Mary Peach, Julia May Heslop, Paul Stephen Donnelly
  • Publication number: 20120270850
    Abstract: The present invention relates to metal complexes, processes for their preparation and their use as pharmaceutical or veterinary agents, in particular for the treatment of conditions in which metal delivery can prevent, alleviate or ameliorate the condition. There are a number of clinical conditions which are caused by or associated with abnormal levels of metals (typically low metal levels). Conditions in of this type include cancer and conditions characterised by or associated with oxidative damage, more specifically neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease or Huntington's disease. The invention also relates to ligands useful in the preparation of metal complexes of this type.
    Type: Application
    Filed: November 20, 2007
    Publication date: October 25, 2012
    Applicant: UNIVERSITY OF MEDLBOURNE
    Inventors: Kevin Jeffrey Barnham, Paul Stephen Donnelly, Anthony Robert White
  • Patent number: 8293282
    Abstract: Disclosed is a wood preservative composition comprising micronized copper and copper-amine complex, wherein the copper component of the copper amine complex is from about 5% to about 50% by weight, based upon the total weight of copper in the composition. The copper amine complex serves to avoid wood surface “chalking” that is otherwise attributable to the presence of micronized copper in copper-based slurries used to treat wood products. In addition, the copper-amine complex enhances the antimicrobial efficacy of the composition when used in wood treatment applications by facilitating cell wall penetration of the treated wood.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: October 23, 2012
    Assignee: Arch Wood Protection, Inc.
    Inventor: Jayesh P. Patel
  • Patent number: 8282951
    Abstract: Antimicrobial coatings to protect surfaces and a method of applying such a coating are disclosed. An antimicrobial coating may be applied to a surface, such as the interior surface of a building's exterior wall. The interior surface must be accessed, and then an antimicrobial coating is provided and applied. The antimicrobial coating includes an inorganic antimicrobial additive and a colloidal polymeric medium. The inorganic antimicrobial additive may be silver, platinum, gold, palladium, copper, zinc, boron, or a compound of any of those elements. By including an ultraviolet tracer or color dye additive in the coating, it is possible to detect the coating at any time, provided that the surface is accessed.
    Type: Grant
    Filed: January 4, 2010
    Date of Patent: October 9, 2012
    Assignee: EnviroCare Corporation
    Inventor: Bryan M. Redler
  • Publication number: 20120238448
    Abstract: The present invention relates to a method for controlling phytopathogenic microorganisms by treating the crop to be protected, the soil or the plant propagation material with an effective amount of copper salt particles which comprise a water-soluble polymer and which have a primary particle diameter of from 1 to 200 nm. The invention also relates to an aqueous suspension of the abovementioned copper salt particles and the use of this suspension in crop protection.
    Type: Application
    Filed: November 29, 2010
    Publication date: September 20, 2012
    Applicant: BASF SE
    Inventors: Karl-Heinrich Schneider, Andrey Karpov, Hartwig Voss, Sarah Dunker, Michael Merk, Alexander Kopf, Shoichi Kondo
  • Patent number: 8221791
    Abstract: A silica-based nanoformulation and method is used to treat citrus canker, inhibit the growth of mold and mildew, and add nutrients to soil used for agricultural purposes. The nanotechnology-enabled copper-loaded, silica nanoformulation (CuSiNP/NG) design is a “revolutionary re-invention” of Cu for safe application because it provides a formulation with maximum abundance of ionic Cu, provides sustained and optimal Cu ion release for long-term disease protection, better adherence to plant surfaces and structural surfaces due to gel-based nanostructure of CuSiNG, thus avoiding multiple spray applications and reducing the amount of Cu used in comparison to existing Cu compounds without compromising antibacterial activity.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: July 17, 2012
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Swadeshmukul Santra
  • Publication number: 20120177583
    Abstract: Compositions containing polymetal complexes are useful in treating anorectal disorders.
    Type: Application
    Filed: June 16, 2011
    Publication date: July 12, 2012
    Inventor: José E. Ramirez