Copper Patents (Class 514/499)
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Publication number: 20040077714Abstract: Neutral alpha amino diacid complexes of trace minerals and their use for animal nutrition.Type: ApplicationFiled: October 16, 2002Publication date: April 22, 2004Applicant: Zinpro CorporationInventors: Mahmoud M. Abdel-Monem, Michael D. Anderson
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Patent number: 6720350Abstract: Methods are provided for inhibiting stenosis or restenosis following vascular trauma in a mammalian host, comprising administering to the host a therapeutically effective dosage of a cytostatic agent and/or cytoskeletal inhibitor so as to biologically stent the traumatized vessel. Also provided is a method to inhibit or reduce vascular remodeling following vascular trauma, comprising administering an effective amount of a cytoskeletal inhibitor. Further provided are pharmaceutical compositions and kits comprising the therapeutic agents of the invention.Type: GrantFiled: December 27, 2002Date of Patent: April 13, 2004Assignee: SciMed Life Systems, Inc.Inventors: Lawrence L. Kunz, Richard A. Klein, John M. Reno
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Patent number: 6710079Abstract: A composition and method of preparing amino acid chelates and complexes free of interfering ions by blending an amino acid ligand, a calcium oxide and/or hydroxide, and a hydrated metal sulfate salt, placing the blend in a closed environment, heating the blend, and allowing the blend to react is disclosed and described. By heating at low to moderate temperatures in an enclosed environment, the waters of hydration of the metal salt are retained in the enclosed environment and serve to provide the moisture necessary to enable a bonding reaction to take place between the electron rich functional groups of the ligand and the metal ion of the hydrated metal sulfate salt. Additionally, calcium sulfate is formed which can be maintained in the final product.Type: GrantFiled: October 11, 2000Date of Patent: March 23, 2004Assignee: Albion International, Inc.Inventors: H. DeWayne Ashmead, Stephen D. Ashmead, David C. Wheelwright, Clayton Ericson, Mark Pedersen
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Patent number: 6706759Abstract: Dithiocarbamate, particularly tetraethylthiuram disulfide, and thiocarbamate anions strongly inhibit the growth of cancer cells of a variety of cell types. Such inhibitory effect is enhanced by heavy metal ions such as copper ions, cytokines and ceruloplasmin. A method is presented for using tetraethylthiuram disulfide to reduce tumor growth, and to potentiate the effect of other anticancer agents.Type: GrantFiled: October 5, 2000Date of Patent: March 16, 2004Assignee: Charlotte-Mecklenburg Hospital AuthorityInventor: Thomas Preston Kennedy
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Patent number: 6703036Abstract: A stomach-action molluscicide, which includes a metal complexone and a suitable additive for enhancing the molluscicidal activity of the metal complexone. The additive may be selected from a surfactant or an additional source of ferric ions. Examples of the surfactant include sodium dodecyl sulphate or sorbitan monostearate, while an example of the additional source of ferric ions is ferric orthophosphate.Type: GrantFiled: May 15, 2000Date of Patent: March 9, 2004Inventor: Colin Leslie Young
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Patent number: 6692774Abstract: Novel synergistic fungicidal compositions used for protecting seeds, plants and other vegetative material against fungi contain a mixture of one or more compounds selected from group A and one or more compounds selected from group B. Compounds from group A are selected from &bgr;-Amino butyric acid and its N-benzoyl-octyl ester derivatives. Compounds from group B are selected from the group of fosetyl aluminum, dimethomorph, a mixture of folpet and ofurace (45:5), folpet, fencaramid (Bayer SZX), mancozeb, cymoxanil, methalaxyl, the single optical isomer of metalaxyl, a mixture of cymoxanil and mancozeb (4:1), copper sulfate, copper hydroxide, copper sulfate hydrate, azoxystrobin, and acibenzolar-s-methyl.Type: GrantFiled: May 16, 2002Date of Patent: February 17, 2004Assignee: Agrogene Ltd.Inventors: Yigal Cohen, Moshe Korat, Dan Zvi-Tov
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Patent number: 6689392Abstract: A composition for controlling growth of pathological organisms on a plant, said composition comprises an effective amount of one or more of metal ion(s); one or more of chelating agent(s); and phosphorous acid, and/or salt or hydrate thereof, said composition is in an agriculturally compatible carrier or vehicle.Type: GrantFiled: January 29, 2002Date of Patent: February 10, 2004Assignee: Agricare Ltd.Inventor: Ran Lifshitz
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Publication number: 20040006055Abstract: Compounds that demonstrate chelation affinity and selectivity for first transition series elements are administered to patients suffering from such conditions as ischemia, prolonged seizures and trauma to provide neuroprotection, cardioprotection, or both. These compounds when administered form complexes with chelatable iron and copper cations and thereby mitigate the ability of these cations to catalyze Haber-Weiss reactions that form toxic hydroxy free radicals that cause tissue injury. These compounds also form complexes with chelatable zinc cations thereby inhibiting the cytotoxicity associated with excess chelatable zinc.Type: ApplicationFiled: June 13, 2002Publication date: January 8, 2004Applicants: CONCAT, LTD. a California Limited Partnership, CHELATOR LLC., a Delaware corporationInventor: Harry S. Winchell
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Publication number: 20030232098Abstract: Therapeutic compositions for the treatment of tinnitus are described which contain effective amounts of Ginkgo biloba, garlic and zinc. In formulations containing greater than 50 mg of zinc, the composition may further contain copper. Methods of treating patients having tinnitus include prescribing effective daily doses of the therapeutic compositions of the present invention over a sixty to ninety day period to maximize improvement in the condition, followed by a daily regimen of the therapeutic compositions.Type: ApplicationFiled: June 11, 2003Publication date: December 18, 2003Inventor: Barry Keate
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Patent number: 6653327Abstract: The present invention is directed to a mixture of tetrahydrocurcuminoids which can be used for regulating random, intracellular protein cross-linking an optimizing cell electric potential in a patient.Type: GrantFiled: October 9, 2001Date of Patent: November 25, 2003Assignee: Sabinsa CorporationInventors: Muhammed Majeed, Vladimir Badmaev
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Publication number: 20030213401Abstract: A material and method for treating timber. The material comprises a preservative and a carrier. The carrier is selected such that it remains mobile within the wood and provides for migration of the preservative within the treated wood. By providing a carrier which is mobile within the wood, the timber has a ‘self healing’ effect wherein the carrier/preservative migrates to any freshly cut or exposed surface of the wood to thereby redistribute and treat such a surface within the preservative and hence maintain integrity of a treatment envelope surrounding the wood.Type: ApplicationFiled: June 13, 2003Publication date: November 20, 2003Applicant: Koppers-Hickson Timber Protection Pty LimitedInventor: Peter Ravnor Soundy Cobham
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Patent number: 6649783Abstract: Compositions comprising (±)-2-((dimethylamino)methyl)cyclohexanone, a transition-metal salt, and an organic solvent and methods of preparing (±)-cis-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols, in particular (±)-cis-2-((dimethylamino)methyl)-1-(3-methoxyphenyl)cyclohexanol, are disclosed herein. In one embodiment, the (±)-2-((dimethylamino)methyl)cyclohexanone and transition-metal salt are in the form of a (±)-2-((dimethylamino)methyl)cyclohexanone:transition-metal salt complex. In another embodimemt, aryl is 3-methoxyphenyl.Type: GrantFiled: October 3, 2001Date of Patent: November 18, 2003Assignee: Euro-Celtique, S.A.Inventors: Robert J. Kupper, Andreas Stumpf
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Patent number: 6649649Abstract: This invention is directed to a method of retarding or preventing the transformation of a colonic adenoma to a colonic adenocarcinoma comprising the administration to a patient with FAP or a patient with one or more of said adenomas a non-toxic therapeutically effective amount of NSAID, said amount effective to inhibit the PGHS-2 in said adenoma. The preferred method comprises the administration of a specific PGHS-2 inhibiting agent as defined herein.Type: GrantFiled: March 2, 1999Date of Patent: November 18, 2003Assignees: Merck & Co., Inc., Merck Frosst Canada, & Co.Inventors: Stacia Kargman, Thomas J. Simon, Jilly Evans
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Patent number: 6646000Abstract: A method of treating plant and animal systems and inanimate surfaces for the purposes of controlling plant pests, introducing pesticides and nutrients into plants, mitigating frost damage to plants, increasing crop yields, controlling certain plant diseases, controlling arthropod, bacterial, fungal, mycoplasma, rickettsia, and viral pests of animals and humans, and disinfecting inanimate surfaces. The method utilizes the unique multi-directional dispersion property of the tannate complex of picro ammonium formate and the tannate complex of picro cupric ammonium formate, in aqueous solution, combined with a minor amount of a surfactant sufficient to prevent formation of ammonium picrate, to penetrate plant and animal systems and inanimate surfaces and travelling multidirectionally therein. The method is carried out by introducing a small but effective amount of the tannate complex to the plant or animal system or inanimate surface.Type: GrantFiled: July 6, 2000Date of Patent: November 11, 2003Inventor: Will H. Hartfeldt
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Publication number: 20030206941Abstract: Physiologically acceptable films, including edible films, are disclosed. The films include a water soluble film-forming polymer such as pullulan. Edible films are disclosed that include pullulan and antimicrobially effective amounts of the essential oils thymol, methyl salicylate, eucalyptol and menthol. The edible films are effective at killing the plaque-producing germs that cause dental plaque, gingivitis and bad breath. The film can also contain pharmaceutically active agents. Methods for producing the films are also disclosed.Type: ApplicationFiled: April 17, 2003Publication date: November 6, 2003Inventors: Sau-Hung Spence Leung, Robert S. Leone, Lori D. Kumar, Neema Kulkarni, Albert F. Sorg
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Patent number: 6638431Abstract: A formulation and method to treat and control microbial growth present in the water of climate control systems such as air conditioner air handlers, dehumidifiers, and humidifiers, which formulation can be entrained and dispersed into to living space air. Specifically, a formulation is provided in the form of a tablet or a spray for being applied onto a wetted surface element present in these systems which will effectively control the growth of microbes such as fungus, molds, bacteria, and virus present on the surface for an extended period of time. The formulations include at least two metals, at least two chelating agents, at least one surfactant, and at least one viscosity enhancing compound.Type: GrantFiled: May 3, 2001Date of Patent: October 28, 2003Assignee: Mainstream Engineering CorporationInventors: Dwight D. Back, Robert P. Scaringe, John A. Meyer
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Patent number: 6630172Abstract: Disinfectant formulations are described which are preferably ecologically friendly and non-toxic to mammals and plants, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The microbicidal formulation contains complexes having at least one metal ion which is microbicidal to at least one microorganism and potassium sodium tartrate in some form. When potassium sodium tartrate is used with these metal ions, it enhances the complex-forming properties of such metal complexes while concurrently increases their efficacy and potency at the same level of metal ion concentrations. These microbicidal formulations can be diluted in suitable proportions into aqueous systems to produce the desired dosages for each individual case, depending on the level and the severity of the contamination. The microbicidal formulations can be applied by conventional methods, e.g., spraying, soaking, fogging, impregnation, and the like.Type: GrantFiled: January 22, 2001Date of Patent: October 7, 2003Inventor: Kareem I. Batarseh
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Publication number: 20030187066Abstract: A biocidal composition comprising copper (II) oxalate.Type: ApplicationFiled: March 13, 2003Publication date: October 2, 2003Inventor: John Murray Brigatti
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Publication number: 20030158171Abstract: A method for reducing alcohol desire or dependency in a human can comprise the steps of administering a chelate or a combination of chelates to a human having alcohol dependency symptoms or an unwanted desire for alcohol. Ligands that can be used include carnitine, naturally occurring amino acids, and various thiamine molecules. Metals that can be used include nutritionally relevant metals, including copper, zinc, and manganese, to name a few.Type: ApplicationFiled: November 26, 2002Publication date: August 21, 2003Applicant: Albion International, inc.Inventors: H. DeWayne Ashmead, R. Charles Thompson
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Patent number: 6596733Abstract: Nitric oxide scavengers, such as dithiocarbamate-containing compounds, are used to reduce side effects caused by therapeutic administration of nitric oxide sources by administering the nitric oxide scavenger(s) to the subject after the therapeutic effect of the nitric oxide source has been achieved. For example, the nitric oxide source can be coadministered with the nitric oxide scavenger, with the latter formulated in a time release vehicle selected to delay release of the scavenger for a period of time sufficient to ensure that the therapeutic goal of the nitric oxide source has been achieved before release of the scavenger. Formulations and kits, including a bubble pack with pairwise arrangement of unit doses of a desired nitric oxide source and nitric oxide scavenger, are also provided.Type: GrantFiled: July 24, 2001Date of Patent: July 22, 2003Assignee: Medinox, Inc.Inventor: Ching-San Lai
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Patent number: 6593361Abstract: This invention is directed to a method of retarding or preventing the transformation of a colonic adenoma to a colonic adenocarcinoma comprising the administration to a patient with FAP or a patient with one or more of said adenomas a non-toxic therapeutically effective amount of NSAID, said amount effective to inhibit the PGHS-2 in said adenoma. The preferred method comprises the administration of a specific PGHS-2 inhibiting agent as defined herein.Type: GrantFiled: October 12, 2001Date of Patent: July 15, 2003Inventors: Stacia Kargman, Jilly Evans, Thomas J. Simon
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Patent number: 6589987Abstract: Dithiocarbamate, particularly tetraethylthiuram disulfide strongly inhibits the growth of cancer cells of a variety of cell types. Such inhibitory effect is enhanced by heavy metal ions such as copper ions, cytokines and ceruloplasmin. A method is presented for using tetraethylthiuram disulfide to reduce tumor growth, and to potentiate the effect of other anticancer agents.Type: GrantFiled: September 8, 1999Date of Patent: July 8, 2003Assignee: Charlotte-Mecklenburg Hospital AuthorityInventor: Thomas Preston Kennedy
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Patent number: 6579904Abstract: Betaine transition metal complexes are formed by: a) reacting a solution including an alkali metal salt of chloroacetic acid with a solution including the transition metal salt to give a solution including a chloroacetate transition metal complex; and b) reacting the solution including the chloroacetate transition metal complex with trimethylamine to give a solution including the betaine transition metal complex. Such betaine transition metal complexes may be used as a feed supplement for animals in the process of preparing such animals for market.Type: GrantFiled: September 22, 2000Date of Patent: June 17, 2003Assignee: K.E.R. Associates, Inc.Inventors: Harvey B. Hopps, Gary Culp, Steven B. Malcolm, Ken W. Ridenour, Jay Thurman
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Patent number: 6576594Abstract: A method of controlling algae in a municipal water plant including the step of adding an algicide-flocculant solution including 25-50 wt % acidic flocculent, 0-10 wt % polymer flocculant aid, an algicide consisting essentially of copper having a concentration of 0.025-1.275 wt % in the form of a water soluble copper salt, balance water. The algicide-flocculant solution may be added to the water via a clarifier of the water plant, a basin of the water plant, or a mixing chamber. The mixing chamber may be located within the clarifier, adjacent to the basin, or upstream of the clarifier and/or the basin.Type: GrantFiled: June 18, 2001Date of Patent: June 10, 2003Assignee: Bay Chemical and Supply CompanyInventors: Thomas J. Nier, Tosby L. Linn
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Publication number: 20030104043Abstract: A basic therapeutic unit comprises an aqueous solution of copper associated with a skin- and tissue-penetration enabler. Topical application of the unit to the skin penetrates therethrough and through subjacent tissue so that the copper resides at the sites of spider veins for the alleviation or elimination thereof. The copper solution may be copper gluconate and the enabler may be a liposome. A quantity of these therapeutic units may be suspended in a cream or emollient. Additional substances, such as vasodilators, thickeners, preservatives and dispersants may be encapsulated by or contained in the bilayer of the liposome or may be added to the cream.Type: ApplicationFiled: December 3, 2001Publication date: June 5, 2003Inventors: Beverly Ann Brown, Gary Osborn
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Patent number: 6565891Abstract: A multinutrient nutritional supplement is provided that is designed to be most effective in optimizing health, increasing the immunity and decreasing the instances and severity of infection particularly among children.Type: GrantFiled: August 23, 2002Date of Patent: May 20, 2003Assignee: Tsar Health Private Ltd.Inventor: Ranjit Kumar Chandra
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Patent number: 6562378Abstract: A multinutrient nutritional supplement is provided that is designed to be most effective in optimizing health, increasing the immunity and decreasing the instances and severity of infection particularly among adolescents.Type: GrantFiled: August 16, 2002Date of Patent: May 13, 2003Assignee: TSAR Health Private Ltd.Inventor: Renjit Kumar Chandra
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Patent number: 6548540Abstract: Dithiocarbamate, particularly tetraethylthiuram disulfide, and thiocarbamate anions strongly inhibit the growth of cancer cells of a variety of cell types. Such inhibitory effect is enhanced by heavy metal ions such as copper ions, cytokines and ceruloplasmin. A method is presented for using tetraethylthiuram disulfide to reduce tumor growth, and to potentiate the effect of other anticancer agents.Type: GrantFiled: December 12, 2000Date of Patent: April 15, 2003Assignee: Charlotte-Mecklenburg Hospital AuthorityInventor: Thomas Preston Kennedy
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Patent number: 6521265Abstract: A method of arresting the flow of blood and other protein containing body fluids flowing from an open wound and for promoting wound healing. In the method, a substantially anhydrous compound of a salt ferrate is provided for a unique use which, when hydrated after mixing with a victim's own blood or other aqueous media, produces Fe+++ thereby promoting clotting when applied in a paste form to the wound for a time sufficient to arrest substantial further blood and other body fluid flow from the wound. The compound is formed of a ferrate (VI) salt taken from the group consisting of H, Li, Na, K, Rb, Cs and Fr. However, to decrease or eliminate stinging sensation, the compound may be formed having a ferrate (VI) salt taken from the group consisting of Be, Mg, Ca, Sr, Ba, Ra, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, In, Sn, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, TI, Pb, Bi, Al, As, NH4 and N(C4H9)4.Type: GrantFiled: June 13, 2000Date of Patent: February 18, 2003Assignee: Biolife, L.L.C.Inventor: James A. Patterson
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Patent number: 6515009Abstract: Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent.Type: GrantFiled: February 15, 1995Date of Patent: February 4, 2003Assignee: NeoRx CorporationInventors: Lawrence L. Kunz, Richard A. Klein
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Publication number: 20030013759Abstract: Disclosed are methods of selectively reducing the blood supply to a neoplastic region, such as a tumor region, thereby selectively causing necrosis of the neoplastic tissue without substantial necrosis of adjoining tissues. In particular, methods are disclosed of selectively reducing the blood supply to a neoplastic region, such as a tumor region, by causing selectively occlusion of blood vessels feeding the neoplastic region. The invention also provides methods of selectively causing anti-angiogenic action in a neoplastic region, such as a tumor region, with the result that new blood vessels are not formed to sustain the neoplasia. The methods employ intra-arterial injection of polyunsaturated fatty acids, preferably in the form of salts, preferably with a lymphographic agent, and optionally with an anti-cancer drug, and/or a cytokine. The invention also provides solutions of PUFAs, or salts of PUFAs, in combination with a lymphographic agent.Type: ApplicationFiled: May 24, 2002Publication date: January 16, 2003Applicant: EFA SciencesInventor: Undurti N. Das
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Patent number: 6506795Abstract: A chromium-free wood preservative consisting essentially of 1 to 35% by weight of a mixture of 25 to 75 parts by weight of a fatty amine ethoxylate and 75 to 25 parts by weight of at least one member of the group consisting of an unsaturated fatty acid of 3 to 25 carbon atoms and their copper and zinc salts and water.Type: GrantFiled: March 26, 1996Date of Patent: January 14, 2003Assignee: WEYL GmbHInventors: Volker Barth, Helmut Hartner, Volker Beez
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Patent number: 6503936Abstract: A fungicidal mixture comprising a.1) a carbamate of the formula I.a, in which X is CH or N, n is 0, 1 or 2 and R is halogen, C1-C4-alkyl or C1-C4-haloalkyl, where the radicals R can be different if n is 2, and b) a copper-containing fungicidal active compound (II) in a synergistically active amount.Type: GrantFiled: May 17, 2001Date of Patent: January 7, 2003Assignee: BASF AktiengesellschaftInventors: Klaus Schelberger, Maria Scherer, Reinhold Saur, Hubert Sauter, Bernd Müller, Erich Birner, Joachim Leyendecker, Eberhard Ammermann, Gisela Lorenz, Siegfried Strathmann
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Publication number: 20020177583Abstract: Methods and compositions for altering the viability of cells, particularly cancers in animals and humans are disclosed. The compositions of the present invention are formed from a set of components comprising one or more of the following: a dithiocarbonyl, preferably dithiocarbamate, compound; a divalent metal ion; a modulator of cellular glutathione levels; and an inhibitor of the phosphorylation of choline. The compositions described herein induce a relatively selective and rapid effect on the viability of cancer cells by inducing a mixture of apoptotic and necrotic cell death, with the dominant pathway being apoptosis. Particularly preferred active compositions comprise all four components, although combinations of fewer components can be fully effective in certain tumors.Type: ApplicationFiled: May 24, 2001Publication date: November 28, 2002Inventor: Zoltan Kiss
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Patent number: 6468657Abstract: Multilayered porous materials are formed by coating a porous substrate with a metal and adsorbing an organic layer comprising a recognition moiety onto the metal film. The recognition moiety interacts with an analyte of interest allowing for its detection, purification, etc. Suitable recognition moieties can be selected from a range of species including, small molecules, polymers and biomolecules and the like. The novel porous materials of the invention can be utilized in an array of methods including, ion-exchange, ion-selective ion-exchange, assays, affinity dialysis, size exclusion dialysis and the like.Type: GrantFiled: December 4, 1998Date of Patent: October 22, 2002Assignee: The Regents of the University of CaliforniaInventors: Zhizhong Hou, Pieter Stroeve, Nicholas Abbott
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Patent number: 6447809Abstract: A dietary supplement for benefitting human bone health includes a calcium source, a source of vitamin D activity, and an osteoblast stimulant. A preferred calcium source is microcrystalline hydroxyapatite, which also contains protein (mostly collagen), phosphorus, fat, and other minerals. A preferred source of vitamin D activity is cholecalciferol, and a preferred osteoblast stimulant is ipriflavone. In addition to these basic ingredients, the composition can further include various other minerals known to occur in bone, vitamin C, and glucosamine sulfate, all of which exert beneficial effects on growth and maintenance of healthy bone. A method for benefitting human bone health involves administering a daily regimen of the dietary supplement.Type: GrantFiled: May 11, 2000Date of Patent: September 10, 2002Assignee: Metagenics, Inc.Inventors: Kim C. Krumhar, Holly A. Johnson
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Patent number: 6444700Abstract: In its broadest aspect, the present invention is directed to the discovery of immunonutritional products that are useful in reducing the immunological system suppression that results from stress. The stress may be in the form of physical exertion, mental exhaustion, disease states and the like. In one embodiment, the invention relates to a nutritional composition comprising a structured glyceride component and an antioxidant system. This nutritional composition has been shown to be highly effective in reducing immune system down regulation or dysregulation as a result of stress.Type: GrantFiled: March 19, 2001Date of Patent: September 3, 2002Assignee: Abbott LaboratoriesInventors: Stephen J. DeMichele, John W. McEwen, Steven M. Wood
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Patent number: 6436421Abstract: The present invention relates to pesticide compositions. In particular, the present invention relates to pesticide compositions comprising a pesticide and a redispersible polymer and to a method for controlling agricultural pests by applying to the pest or the locus of the pest a pesticide composition comprising a pesticide and a redispersible polymer.Type: GrantFiled: February 27, 1998Date of Patent: August 20, 2002Assignee: ?Rohm and Haas CompanyInventors: Frederick James Schindler, Yili Guo, Gregory C. Pierce, James Allen Quinn
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Patent number: 6429219Abstract: This invention relates to the synthesis of certain complexes of cysteine, N-acetylcysteine, N-(2-mercaptopropionyl)glycine, and L-2-oxothiazolidine-4-carboxylate and to the nutritional use of these and other related individual or complexed thiol-contributing glutathione predecessors. Clinical uses for these molecules and complexes in the beneficial modification of various physiological conditions and functions associated with aging, chronic glaucoma, diabetes mellitus, insulin resistance, macular degeneration, neurodegenerative diseases and vasoconstriction are described in particular.Type: GrantFiled: May 3, 2000Date of Patent: August 6, 2002Assignee: Chronorx, LLCInventors: Don C. Pearson, Kenneth T. Richardson
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Patent number: 6426093Abstract: A biocidal composition composed of a ternary complex of a negatively-charged biocide, a transition metal ion and chelator has synergistic biocidal effects as compared with a composition of each of the components alone. The chelator is preferably a neutral or positively-charged chelator. The ternary complex may be used for killing or inhibiting the growth of living cells.Type: GrantFiled: February 9, 1999Date of Patent: July 30, 2002Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Mordechai Chevion, Benzhan Zhu, Svetlana Schechtman
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Patent number: 6423349Abstract: Compositions comprising glutamine in combination with other nutrients, including N-acetyl-cysteine and Vitamins A, C, E are disclosed. Such compositions can be administered for promoting recovery in patients undergoing elective surgery and for treating multiple organ system failure.Type: GrantFiled: August 24, 2000Date of Patent: July 23, 2002Assignee: Baxter International, Inc.Inventors: J. Dale Sherratt, Joann Somerville
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Patent number: 6420312Abstract: An algicide-flocculant solution for use in treating raw water in a municipal water plant to control algae, the algicide-flocculant solution including 25-50 wt % of an acidic flocculant, 0-10 wt % of a polymer flocculant aid, an algicide of essentially copper having a concentration of 0.025-1.25 wt % in the form of a water soluble capper salt, and balance water. Uniform mixing of the flocculant into the raw water simultaneously uniformly mixes the algicide of the algicide-flocculant solution into the raw water. The acidic flocculant is preferably aluminium sulfate, iron sulfate, iron chloride or mixtures thereof. The water soluble copper salt is preferably copper sulfate, copper chloride, copper nitrate, copper acetate or mixtures thereof. Moreover, the flocculant aid is a high molecular weight quaternary amine such as diallyldimethylammonium chloride.Type: GrantFiled: June 11, 2001Date of Patent: July 16, 2002Assignee: Bay Chemical and Supply CompanyInventors: Thomas J. Nier, Tosby L. Linn
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Publication number: 20020091113Abstract: The use of transition metal complexes in the treatment of septic shock in particular the hypotension associated therewith and pharmaceutical formulations comprising such complexes are disclosed. The use of such transition metal complexes in the treatment of other conditions caused by pathological NO production are also disclosed.Type: ApplicationFiled: October 5, 2001Publication date: July 11, 2002Applicant: Molichem Medicines, Inc.Inventors: Wieslaw Mieczyslaw Kazmierski, Luis Molina
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Publication number: 20020086046Abstract: The present invention provides compositions and methods for controlling terrestrial molluscs. In one aspect, compositions of the present invention are ingestable poisons that are lethal to terrestrial molluscs. In particular, compositions of the present invention comprise an active ingredient for controlling terrestrial mollusc, wherein the active ingredient comprises a complex of edetic acid (i.e., ethylene diamine tetra-acetic acid or EDTA), preferably a metal EDTA complex.Type: ApplicationFiled: August 2, 2001Publication date: July 4, 2002Inventors: Greg Deitch, Russell Brown
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Patent number: 6407138Abstract: The present invention relates to compositions and methods of preparing amino acid chelates that are electrically neutral and free of interfering ions. The composition is prepared by reacting in an aqueous solution a calcium oxide and/or hydroxide, an amino acid, and a soluble metal sulfate salt at a ratio sufficient to allow substantially all of the ions present in solution to react forming a metal amino acid chelate and an essentially inert calcium sulfate, and wherein the metal amino acid chelate has a ligand to metal molar ratio from 2:1 to 3:1.Type: GrantFiled: October 11, 2000Date of Patent: June 18, 2002Assignee: Albion International, Inc.Inventors: Stephen D. Ashmead, David C. Wheelwright, Clayton Ericson, Mark Pedersen
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Patent number: 6403642Abstract: Compositions for adsorbing sulfur-containing compounds and eliminating or reducing odors associated with the ingestion of foods or medicines causing sulfur odor, such as garlic and onions, contain a metal complex of a substrate and a ligand. The complex may be contained in a carrier, such as a silica gel, and has low solubility in an aqueous environment. The ligand of the compositions may comprise an amino acid containing sulfur, nitrogen, or a carboxylic acid, such as cystine, and the substrate is a metal which may be copper, zinc, or iron.Type: GrantFiled: August 14, 2000Date of Patent: June 11, 2002Assignee: PQ Holding, Inc.Inventor: Kenneth A. Berg
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Patent number: 6403641Abstract: A method for the treatment of obesity in a human in need of such treatment which comprises administration to the human of a therapeutically effective amount of a compound of formula I including enantiomers and pharmaceutically acceptable salts thereof, in which R1 and R2 are independently H or methyl, and a therapeutically effective amount of a compound of formula II wherein the compound of formula I and the compound of formula II are administered simultaneously, separately or sequentially.Type: GrantFiled: December 16, 1998Date of Patent: June 11, 2002Assignee: Abbott LabortoriesInventors: David John Heal, Helen Christine Jackson
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Patent number: 6387412Abstract: A storage stable magnesium oxychloride coated granular animal feed mineral supplement composition resistant to disintegration cause by moisture absorption and attrition, comprising granular mineral nutrients useful as animal feed supplements and magnesium oxychloride coatings amounting to between 0.5 and 10.0 percent of the weight of the granules, formed on the granules of mineral nutrients by coreaction of magnesium chloride and magnesium oxide. An additional coating of between 0.2 and 2.0 percent magnesium stearate formed on the magnesium oxychloride may be used to decrease the rate of wetting of the granular animal feed mineral supplements.Type: GrantFiled: April 14, 2000Date of Patent: May 14, 2002Assignee: Agri-Nutrients Technology Group, Inc.Inventor: William P. Moore
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Patent number: 6387415Abstract: Metal-containing biocides for treating swimming pool water, spas, cooling towers, or other industrial applications without staining are disclosed. The biocidal compositions include a source of metal and a polymeric sequestering agent. The polymeric sequestering agent may be a water-soluble anionic or cationic polymer. Conventional sequestering agents may also be included in the composition.Type: GrantFiled: April 1, 1998Date of Patent: May 14, 2002Assignee: Bio-Lab, Inc.Inventor: John P. Garris
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Patent number: 6362370Abstract: Wood preservatives having biocidal properties which include quaternary ammonium compounds of general formula (I): wherein R1 is a C8-18-alkyl group or an optionally substituted benzyl group, R2 is a C8-18-alkyl group, R3 is a C1-4-alkyl group or a group of the formula —[CH2—CH2—O]n—H, R4 is a C1-4-alkyl group, n is a number from 0.5 to 8, preferably from 1 to 5, and A31 is the anion of an organic carboxylic acid which contains 2 to 12 C atoms and carries at least one hydroxyl, amino or sulfonic acid group. The wood preservatives also penetrate deeply into the wood without the use of pressure, and have only a mild corrosive action on metals. Furthermore, a process for treating timbers with these compositions, concentrates for the preparation thereof, the use of new and known quaternary ammonium compounds in wood preservatives and new quaternary ammonium compounds and their use as biocides.Type: GrantFiled: September 6, 2000Date of Patent: March 26, 2002Assignee: Lonza AGInventors: Florian Lichtenberg, Joachim Fritschi, Volker Ranft