Abstract: The present invention relates generally to paints and paint bases, and, more specifically to a process for providing a stable gel-free dispersion of biocidal amounts of 2,2'-dithiobis(pyridine-1-oxide) or its metal salt adducts of the formula (C.sub.5 H.sub.4 NOS).sub.2 MY.sub.t or their hydrates plus cuprous oxide biocide in paint, where M is an alkaline earth metal, Y is the anion of an organic or inorganic acid, and t is 1 or 2. The resulting paint is storage stable and remains gel-free after several months of storage at room temperature.

Abstract: The present invention relates generally to paints and paint bases, and, more specifically to a process for providing in situ generation of copper pyrithione biocide in a paint or paint base which comprises incorporating a metal salt of pyrithione, cuprous oxide and a controlled amount of water into the paint or paint base either during or after formulation of the paint or paint base.

Abstract: The present invention relates generally to paints and paint bases, and, more specifically to a process for providing in situ generation of copper pyrithione biocide in a paint or paint base which comprises incorporating a compound of pyrithione, cuprous oxide and a controlled amount of water into the paint or paint base either during or after formulation of the paint or paint base.

Abstract: The present invention relates generally to paints and paint bases, and, more specifically to a process and composition for providing a stable gel-free dispersion of zinc pyrithione plus cuprous oxide biocide in paint. In accordance with the process of the present invention, the paint or paint base is essentially water-free, and preferably contains a desiccant in order to impart desired gelation-inhibition to the paint.

Abstract: Disclosed herein are copper based fungicidal and bactericidal compositions having enhanced activity against fungi and bacteria, methods of using such compositions as well as methods for increasing the effectiveness of the copper based fungicidal and/or bactericidal compounds employed in such compositions.

Abstract: Wood preservatives which contain a mixture of an N-organyldiazeniumdioxy-metal salt and a complex-forming polymeric nitrogen compound are used for preserving wood.

Abstract: Water-soluble wood preservatives which contain mixtures of a metal compound, a metal-fixing acid and a complexing polymeric nitrogen compound, and methods for protecting wood with such mixtures.

Abstract: The present invention relates generally to paints and paint bases, and, more specifically to a process for providing a stable gel-free dispersion of copper pyrithione or pyrithione disulfide plus cuprous oxide biocide in paint. The resulting paint is storage stable and remains gel-free after several months of storage at room temperature.

Abstract: A composition for treating swimming pools to inhibit the growth of algae, fungi and bacteria, and to prevent the formation of turbidity in the pool water, more particularly to reduce the dosage of chlorine or chlorine-based chemicals to maintain the pool water in a clear and pathogen-free condition, while at the same time substantially eliminating the risk of deposits and stains being formed on the pool walls, comprises by weight:from about 78 to about 83 percent of copper sulphate, from about 0.08 to about 0.12 percent of silver nitrate, from about 1.0 to about 1.4 percent each of sodium gluconate and zinc chloride or zinc sulphate,from about 16.4 to about 9.6 percent of water, and from about 3.5 to about 4.5 of a complexone, preferably the tetrasodium salt of EDTA.To ensure the desired properties and consistency of the product as well as successful manufacture, the ingredients have to be mixed in a particular manner and sequence of steps.

Abstract: An antifouling marine paint having an antibotic active agent which (1) is toxic to gram negative organisms of the genus Oceanospirillum, (2) is relatively insoluble in seawater to permit a slow leaching into the paint-seawater interface, and (3) is non-photolytic, i.e., is not degraded by exposure to sunlight. Further, when used with a copper base antifouling paint, the antibiotic must not be broken down by the copper in the paint. The antibotic may be selected from the group consisting of chloramphenicol, erythromycin, neomycin, and streptomycin.

Abstract: The present invention relates generally to paints and paint bases, and, more specifically to a process and composition for providing a stable gel-free dispersion of zinc pyrithione plus cuprous oxide biocide in paint. In accordance with the process of the present invention, the paint or paint base contains a metal salt of wood rosin in order to impart desired gelation-inhibition to the paint.

Abstract: An injectable pharmaceutical composition for the treatment of cancers susceptible to treatment therewith, the composition comprising:(a) an effective amount of S-(methylthio)-DL-homocysteine or the L-enantimorph thereof;(b) an effective amount of a copper chelate of nitrilotriacetic acid or an effective amount of a copper chelate of a bis-thiosemicarbazone; and(c) a pharmaceutically acceptable carrier.

Abstract: The present invention relates generally to paints and paint bases, and, more specifically to a process and composition for providing a stable gel-free dispersion of zinc pyrithione plus cuprous oxide biocide in paint. In accordance with the process of the present invention, the paint or paint base contains an amine compound or esterified wood rosin in order to impart desired gelation-inhibition to the paint.

Abstract: The present invention relates generally to paints and paint bases, and, more specifically to a process for providing a stable gel-free dispersion of zinc pyrithione plus cuprous oxide biocide in paint. In accordance with the process of the present invention, the zinc pyrithione is purified to a purity assay of at least 98% in order to provide gellation-inhibition in the paint.

Abstract: This invention relates to an improved paint or paint base composition characterized by enhanced biocidal efficacy. The paint or paint base composition is essentially free of tin, lead, and vanadium and contains a biocide comprising pyrithione salt and a copper salt. The pyrithione salt is present in the paint in an amount of between about 5% and about 50%, and the copper salt is present in an amount of between about 5% and about 50%, the total amount of biocide being between about 10% and about 75%, based upon the total weight of the paint composition.

Abstract: New compounds having utility for enhancing the activity of antifolates are disclosed of the formula: ##STR1## wherein X is selected from hydrogen ##STR2## and R" ; R' is selected from alkyl, alkenyl, alkynyl, substituted and unsubstituted aryl, and substituted and unsubstituted heterocyclic aryl; R" is selected from ##STR3## and R'S; M is selected from OR and secondary amine; and R is selected from hydrogen, alkyl, acyloxymethyl, substituted and unsubstituted aryl, substituted and unsubstituted heterocyclic aryl, amino cation and metal cation.

Abstract: A deodorant composition comprising (A) an acidic phosphoric acid compound and (B) a copper compound and as desired, (C) a reducing agent, and a deodorant composite material comprising a substrate and the deodorant composition included therein.

Abstract: Amino acid chelates having a ligand to divalent metal mole ratio of at least 2:1 and having a molecular weight of not more than 1500 and preferably not more than 1000 and also having a stability constant of between about 10 and 10 are formulated for delivery to one or more specific tissue sites within a mammal. The ligand utilized in formulating the amino acid chelate is a naturally occuring amino acid or a dipeptide, tripeptide or quadrapeptide thereof. The selection of an appropriate ligand with which to form the chelate provides a product that, when entering the bloodstream of the mammal, either by mean of oral ingestion or injection, has a propensity to migrate to one or more targeted tissue sites within the mammal.

Abstract: Wood preservatives based on a copper compound and an aliphatic carboxylic acid and additionally containing a polyamine, and a method for preserving wood with these preservatives.

Abstract: Preservative solutions for wood and other cellulosic fibrous materials are provided which include zinc acetate and copper acetate in an amount at least about the same as the zinc acetate, and optionally boric acid and/or a basic material.

Abstract: Copper-amine complexes comprised of a water-soluble copper salt and a polyamide-amine can be used as fungicides without the addition of ammonia, and they form firmly adhering coatings on leaf surfaces.

Abstract: Presenile and senile dementia, in particular Alzheimer's disease, can be combated or alleviated by administration of an effective amount of a physiologically acceptable lithium compound and an essential fatty acid or a physiologically acceptable salt thereof.

Abstract: An improved process for preparing water-soluble copper salts of carboxylic acids is described. More particularly, the improved process comprises the steps of(A) providing a mixture comprising(A-1) as a copper source, copper metal, a copper oxide or mixtures thereof,(A-2) at least one organic monocarboxylic acid containing about 10 to about 30 carbon atoms,(A-3) at least one alkanolamine compound characterized by the formulaR.sub.1 (R.sub.2)NHwherein R.sub.1 is a hydroxyalkyl group and R.sub.2 may be hydrogen or a hydroxyalkyl group, and(A-4) water,(B) treating the mixture with oxygen at a temperature up to about the reflux temperature of the mixture until the desired water-soluble copper salt is obtained, and(C) recovering the copper salt as an aqueous solution.The mixture (A) can be modified to include one or more dyes to produce colored solutions of the water-soluble metal salts.

Abstract: Heavy metal salts of hyaluronic acid have been prepared. In particular, this invention is directed to silver, gold, cerium and tungsten salts of hyaluronic acid. These heavy metal salts of hyaluronic acid are useful as antimicrobial agents. Gold hyaluronate may also be used to treat arthritis.This invention also concerns methods of making the silver salt of hyaluronic acid as well as compositions containing silver hyaluronate or gold hyaluronate.The invention also concerns composition containing heavy metal salts having radioactively labelled hyaluronate moieties.

Abstract: A mixture of an extract from a plant belonging to the Zygophyllaceae family containing phenolic compositions and a nonalkali metal salt is useful as a pharmaceutical agent, for example, in the treatment of cancer, nonmalignant tumors, osteomyelitis, psoriasis and warts.

Abstract: Copper-dependent enzymes are required for normal brain development and function. Copper deficiency can result in pathological disorders accompanied by convulsive seizures or tremors in man and animals. The present invention is directed to a method for treating convulsions or epilepsy comprising administration of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity. Those compounds include copper complexes of carboxylic acids, acylsalicylates, salicylates, amino acids, imines and known anticonvulsant and antiepileptic drugs.

Abstract: Copper-dependent enzymes are required for normal brain development and function. Copper deficiency can result in pathological disorders accompanied by convulsive seizures or tremors in man and animals. The present invention is directed to a method for treating convulsions or epilepsy comprising administration of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity. Those compounds include copper complexes of carboxylic acids, acylsalicylates, salicylates, amino acids, imines and known anticonvulsant and antiepileptic drugs.

Abstract: Copper-dependent enzymes are required for normal brain development and function. Copper deficiency can result in pathological disorders accompanied by convulsive seizures or tremors in man and animals. The present invention is directed to a method for treating convulsions or epilepsy comprising administration of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity. These compounds include copper complexes of carboxylic acids, acylsalicylates, salicylates, amino acids, imines and known anticonvulsant and antiepileptic drugs.

Abstract: Flavored, effervescent, water soluble compositions containing water-soluble and oil-soluble vitamins and amino acid chelated minerals in bioavailable form are contained in a composition consisting of 20-30% of a vitamin blend consisting of water-soluble and oil-soluble vitamins adsorbed on a lactose carrier containing a minor amount of propylene glycol, 5-25% of one or more amino acid chelated minerals selected from the group consisting of calcium, magnesium, iron, zinc, copper and manganese, 20-45% citric acid, 5-25% of one or more alkali or alkaline earth metal bicarbonates or carbonates, 1-5% flavoring agent, 0.5-2% of a sweetening agent and sufficient additional lactose carrier to provide the desired vitamin and mineral content per unit dosage which will normally vary between about 2 and 6 grams. When dissolved in water a flavored, lightly carbonated drink is provided which will contain in soluble bioavailable form between about 50 to 100% of the U.S.

Abstract: A method of treating inflammation or arthritis with metal complexes that can traverse skin and animal cell membranes intact and effectively deliver and release metal ions in a controlled manner upon demand at the targeted inflammatory or arthritic areas containing endogenous reacting moieties which demand the metal ions. The metal complexes have an aqueous proton induced dissociation property represented by a sigmoidally-shaped curve on a cartesian coordinate plot of the negative log of the metal ion concentration versus the negative log of hydrogen ion concentration. This dissociation property enables the metal complexes to release metal ions in a controlled manner upon demand at the targeted inflammatory or arthritic areas containing endogenous reacting moieties which demand the metal ions. The metal complexes can be effectively administered either topically or subcutaneously.

Abstract: A sustained release device which comprises a source of at least one trace chemical element incorporated in a cement and releasable therefrom on contact with an aqueous medium. A preferred cement is copper phosphate cement.

Abstract: Methods are described for using organic copper complexes or their solvates, which exhibit superoxide dismutase activity and act as superoxide radical scavengers, as radioprotectants to protect mammalian cells from damage caused by gamma- or x-irradiation. Treatment can result in the protection of normal tissues in cancer patients undergoing radiotherapy and in the protection of individuals who may be at risk with regard to hazardous effects of exposure to occupational or environmental ionizing radiation.

Abstract: The present invention relates to the use of the sulphenic acid amides of the general formula (I) ##STR1## in which X represents identical or different halogen atoms,Y.sup.1 and Y.sup.2 are identical or different and represent hydrogen, halogen, alkyl, alkoxy, halogenoalkyl or NO.sub.2 andZ represents halogen, --OH, --NHOH or the group --OR.sup.1,in whichR.sup.1 denotes optionally substituted radicals from the series comprising alkyl, alkenyl, alkinyl, cycloalkyl, aryl, aralkyl and heterocyclyl, orZ represents the group ##STR2## in which R.sup.2 and R.sup.3 are identical or different and denote hydrogen or a heterocyclic radical, orZ represents the group --OMin which M denotes ammonium or the equivalent of an alkali metal, alkaline earth metal or heavy metal cation, for prolonging the duration of a high activity in agents for combating soil pests.

Abstract: A mixture of zinc or copper salts of primary and/or secondary saturated acyclic carboxylic acids with zinc or copper salts of a tertiary saturated acyclic carboxylic acid has been found to be of value as a preservative for wood or many other similar degradable organic materials. The mixture can be prepared simply by mixing the salts or by reacting zinc or copper or a suitable zinc or copper compound with a mixture of the appropriate acids.