Iron Patents (Class 514/502)
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Publication number: 20020091113Abstract: The use of transition metal complexes in the treatment of septic shock in particular the hypotension associated therewith and pharmaceutical formulations comprising such complexes are disclosed. The use of such transition metal complexes in the treatment of other conditions caused by pathological NO production are also disclosed.Type: ApplicationFiled: October 5, 2001Publication date: July 11, 2002Applicant: Molichem Medicines, Inc.Inventors: Wieslaw Mieczyslaw Kazmierski, Luis Molina
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Patent number: 6407138Abstract: The present invention relates to compositions and methods of preparing amino acid chelates that are electrically neutral and free of interfering ions. The composition is prepared by reacting in an aqueous solution a calcium oxide and/or hydroxide, an amino acid, and a soluble metal sulfate salt at a ratio sufficient to allow substantially all of the ions present in solution to react forming a metal amino acid chelate and an essentially inert calcium sulfate, and wherein the metal amino acid chelate has a ligand to metal molar ratio from 2:1 to 3:1.Type: GrantFiled: October 11, 2000Date of Patent: June 18, 2002Assignee: Albion International, Inc.Inventors: Stephen D. Ashmead, David C. Wheelwright, Clayton Ericson, Mark Pedersen
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Publication number: 20020058696Abstract: An antibacterial agent is provided, which has an action for inhibiting growth of Helicobacter pylori participating to occurrence of chronic gastritis and gastric ulcer, and a highly safe substance is used as an effective component therein. An antibacterial agent for Helicobacter pylori is characterized in that at least one substance selected from the group consisting of ethylenediaminetetraacetic acid and its metal salts is contained as an effective component.Type: ApplicationFiled: March 8, 2001Publication date: May 16, 2002Applicant: DIRECTOR OF NTL. INST. OF AGROBIOLOGICAL RESOURCES , MINISTRY OF AGRICULTURE, FORESTRY AND FISHERIESInventors: Toshiro Nagai, Shigeru Oita
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Patent number: 6387412Abstract: A storage stable magnesium oxychloride coated granular animal feed mineral supplement composition resistant to disintegration cause by moisture absorption and attrition, comprising granular mineral nutrients useful as animal feed supplements and magnesium oxychloride coatings amounting to between 0.5 and 10.0 percent of the weight of the granules, formed on the granules of mineral nutrients by coreaction of magnesium chloride and magnesium oxide. An additional coating of between 0.2 and 2.0 percent magnesium stearate formed on the magnesium oxychloride may be used to decrease the rate of wetting of the granular animal feed mineral supplements.Type: GrantFiled: April 14, 2000Date of Patent: May 14, 2002Assignee: Agri-Nutrients Technology Group, Inc.Inventor: William P. Moore
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Publication number: 20020049161Abstract: The present invention is directed to a pharmaceutical combination preparation comprising 2,000-7,000 U of recombinant human erythropoietin (EPO) and 5-20 mg of an Fe(III) complex, wherein the rhEPO and the Fe(III) complex may be present in separate administration forms or in an integrated administration form.Type: ApplicationFiled: October 29, 2001Publication date: April 25, 2002Applicant: Roche Diagnostics GmbHInventor: Paul Lehmann
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Patent number: 6352706Abstract: An ingestible mollusc poison contains a simple metal compound, an activity enhancing additive such as ethylene diamine disuccinic acid (EDDS) and derivatives thereof, and a carrier material edible to molluscs. In one embodiment the active agent of the mollusc poison may be in the form of a metal complex of EDDS. The composition may be used alone or in conjunction with molluscicidal co-active agents and/or fertilizers.Type: GrantFiled: February 1, 1999Date of Patent: March 5, 2002Assignee: W. Neudorff GmbH KGInventor: George S. Puritch
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Publication number: 20020006426Abstract: A stomach-action molluscicide including a metal complexone as an active ingredient The term “complexone” as used herein refers to an organic ligand containing at least one iminodiacetic group —N(CH2CO2H2)2 or two aminoacetic groups —NHCH2CO2H which form stable complexes with most cations. Preferably, the complexone is a derivative of ethylenediaminetetraacetic acid.Type: ApplicationFiled: July 9, 2001Publication date: January 17, 2002Inventor: Colin Leslie Young
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Patent number: 6339080Abstract: The present invention is directed to complexes comprising iron in the ferric state and a hydroxypyrone. The present invention is also directed to methods of making such complexes and to the use of the complexes in the treatment and prevention of iron deficiency disorders including iron deficiency anaemia.Type: GrantFiled: December 9, 1997Date of Patent: January 15, 2002Assignee: Vitra Pharmaceuticals Ltd.Inventors: Michael Arthur Stockham, Robert Charles Hider
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Patent number: 6326397Abstract: The present invention relates to novel retinoid antagonists of the formula I wherein the dotted bond can be either hydrogenated or form a double bond; and, when the dotted bond forms a double bond, R1 is lower alkyl and R2 is hydrogen; and, when the dotted bond is hydrogenated, R1 and R2 taken together are methylene to form a cis-substituted cyclopropyl ring; R3 is hydroxy or lower alkoxy; R4 is alkyl or alkoxy; and R5 and R6 are, independently, a C4-12 alkyl or a 5-12 cycloalkyl substituent containing from 1-3 rings which are either unsubstituted or substituted with from 1-3 lower alkyl groups, with the carbon atom of R5 and R6 being linked to the remainder of the molecule to form a quaternary carbon atom pharmaceutically acceptable salts of carbocylic acids of the formula I; as well as method for the treatment of osteoporosis and preneoplastic and neoplastic diseases, and a method for reducing or abolishing adverse events in subjects receiving retinoid agonist treatment by administering aType: GrantFiled: May 7, 1999Date of Patent: December 4, 2001Assignee: Hoffman-La Roche Inc.Inventors: Werner Bollag, Michael Klaus, Peter Mohr, Paola Panina-Bordignon, Michael Rosenberger, Francesco Sinigaglia
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Publication number: 20010047034Abstract: The invention provides methods for inhibiting oxidative degradation of pharmaceutical formulations comprising at least one oxidation-susceptible active drug ingredient which methods comprise adding an oxidation-inhibiting amount of a ferrous ion source, preferably in the form of a pharmaceuticalexcipient, to the formulation.Type: ApplicationFiled: March 9, 2001Publication date: November 29, 2001Inventor: Hai Wang
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Patent number: 6323354Abstract: A method of preparing amino acid transition metal chelates a palatable highly bioavailable source of transition metals for animal nutrition from lipoproteins and transition metal salts. The method requires strong aqueous base hydrolysis of the lipoproteins to sodium or potassium salts of alpha amino acids mixed with fatty acids. The salts are neutralized to amino acids mixed with fatty acids before the aqueous mixture is reacted with transition metal salts to form aqueous chelates. The aqueous mixture is dried and granulated to form a dry product comprising transition metal chelates homogeneously mixed with fatty acids. The new granular composition containing zinc, iron, manganese, copper, cobalt, or chromium provides a palatable and highly bioavailable source of transition metals for animal nutrition. Effective sources of lipoproteins are fractured cell walls of microbes generated in biological syntheses.Type: GrantFiled: March 16, 2001Date of Patent: November 27, 2001Assignee: Agri-Nutrients Technology Group, Inc.Inventor: William P. Moore
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Publication number: 20010044425Abstract: Compositions comprising ferrous ion and an ascorbate have a synergistic effect on cartilage development. Therapeutic compositions comprising ferrous ion and an ascorbate are therefore useful in the treatment of osteoarthritis. The addition of a glucosamine, such as glucosamine hydrochloride, to the composition has a further enhanced effect on cartilage production. Therapeutic compositions comprising ferrous ion, an ascorbate and a glucosamine derivative are even more useful in the treatment of osteoarthritis.Type: ApplicationFiled: April 25, 2001Publication date: November 22, 2001Inventor: V.G. Sunetra Ekanayake
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Publication number: 20010041738Abstract: Acesulfame-metal complexes, formed from a trace element, preferably Fe, Zn, Cu, Mn, Co and 2 molecules of acesulfamic acid by precipitation reaction with the use of suitable salts, are distinguished by a pleasantly sweet taste and are therefore suitable as sweeteners, food supplements and for enrichment of food, medicaments and feeds with trace elements.Type: ApplicationFiled: March 16, 2001Publication date: November 15, 2001Inventor: Andreas Burgard
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Patent number: 6316652Abstract: The invention relates to novel targeting drug agents that are targeted for entry into the mitochondria. More specifically, the agents are cisplatin derivatives called mitoplatins which are useful as anti-tumor agents. Mitoplatins are named for their targeting to the mitochondrial DNA via the carnitine-acylcarnitine translocase system. The invention also relates to methods of synthesizing mitoplatins, compositions of matter containing mitoplatins and methods of using the mitoplatins.Type: GrantFiled: June 6, 1995Date of Patent: November 13, 2001Inventor: Kosta Steliou
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Patent number: 6313170Abstract: A compound of ferrous L-threonate with structure (I), its compostions and methods useful for iron supplementation for mammals, particularly for human body to improve and treat nutritional iron-deficiency anemia, blood loss anemia and hemolytic anemia.Type: GrantFiled: February 29, 2000Date of Patent: November 6, 2001Inventors: Kai Yu, Zhiwen Wang, Fuping Kou
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Publication number: 20010031748Abstract: Compositions and methods for treating gastrointestinal symptoms and gastrointestinal microbes are provided. In accordance with the method, a dietary metal and a dietary ligand are administered, wherein the dietary metal is zinc, copper, cobalt, manganese or iron and the dietary ligand is ascorbate, aspartate, citrate, histidine, malate, maltol, gluconate, glutamate, glutamine, succinate, tartrate, or a combination thereof.Type: ApplicationFiled: January 11, 2001Publication date: October 18, 2001Inventors: Richard Paul Hepworth Thompson, Jonathan Joseph Powell, Rosemary Helen Phillips, Sylvaine Francoise Aline Chevalier
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Patent number: 6296881Abstract: Pathogenic bacteria have long posed a threat to mankind, and it has been a goal in the food industry and the medical profession to develop a bactericide that would have a high degree of practicality which included spores in its scope, that would exhibit a pronounced effect on pathogenic bacteria, that would be safe for humans and the earth, and that would be composed of metal ions having affinity with the body, that is, those which are essential structural components for the body, and compounds that are used in food additives. Provided are a bactericide containing ferric ions (Fe3+) and one or more members of the group consisting of sorbic acid, benzoic acid, and para-hydroxybenzoic acid esters; a bactericide containing ferric ions (Fe3+), L-ascorbic acid, and one or more members of the group consisting of sorbic acid, benzoic acid, and para-hydroxybenzoic acid esters; and a bactericide containing ferric ions (Fe3+), sorbic acid, benzoic acid, and L-ascorbic acid.Type: GrantFiled: August 3, 1999Date of Patent: October 2, 2001Assignee: Kenkohyakunijussai Co., Ltd.Inventors: Tadayo Hata, Toshiyuki Maruoka
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Patent number: 6270809Abstract: The invention provides methods for producing edible plant tissue biomasses suitable for use as nutritional supplements. The seedlings are exposed to at least one metal and normal seedling growth is interrupted prior to the eleventh day following germination to thereby produce a metal-enriched plant seedling tissue biomass. The metal-containing edible plant tissue biomasses are also provided.Type: GrantFiled: November 6, 1998Date of Patent: August 7, 2001Assignee: Phytotech Inc.,Inventors: Burt D. Ensley, Mark Elless, Michael J. Blaylock, Jianwei Huang
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Patent number: 6265420Abstract: Nitric oxide scavengers, such as dithiocarbamate-containing compounds, are used to reduce side effects caused by therapeutic administration of nitric oxide sources by administering the nitric oxide scavenger(s) to the subject after the therapeutic effect of the nitric oxide source has been achieved. For example, the nitric oxide source can be coadministered with the nitric oxide scavenger, with the latter formulated in a time release vehicle selected to delay release of the scavenger for a period of time sufficient to ensure that the therapeutic goal of the nitric oxide source has been achieved before release of the scavenger. Formulations and kits, including a bubble pack with pairwise arrangement of unit doses of a desired nitric oxide source and nitric oxide scavenger, are also provided.Type: GrantFiled: June 23, 1998Date of Patent: July 24, 2001Assignee: Medinox, Inc.Inventor: Ching-San Lai
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Patent number: 6255287Abstract: A method of preparing a product for treating livestock comprising providing as ingredients molasses, water, ethyl alcohol, chelated minerals, and at least a vitamin mix. The method includes the steps of mixing the ethyl alcohol and water first, then adding each of the remaining ingredients separately to the mixture of ethyl alcohol and water. The composition is then mixed until homogeneous to provide a liquid treatment which, when introduced into livestock, will reduce considerably the length of, and amount of, lot adaptation stress.Type: GrantFiled: February 16, 1996Date of Patent: July 3, 2001Assignee: Vit-E-Men Co., Inc.Inventors: Charles Watson, Scott Charles Watson, George G. Gentry
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Patent number: 6251417Abstract: An inorganic antimicrobial composition has the formula AB2O4, wherein A and B are low temperature far infrared irradiating metals, A is Mg, Zn, Mn, Ni, Co, or Fe(II), B is Al, Cr(III), Mn(III) or Fe(III), and O is oxygen. An antimicrobial article is made by coating said composition on a porous honeycomb-shaped substrate. An organic antimicrobial article is made from a quarternary ammonium salt coated on a porous honeycomb-shaped substrate. Processes of making the antimicrobial articles are provided.Type: GrantFiled: July 19, 1999Date of Patent: June 26, 2001Inventors: Yen-Kuen Shiau, Chung-Hsun Wu
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Patent number: 6248369Abstract: A water soluble copper salt, preferably cupric sulfate pentahydrate, is mixed with water. A small quantity of an acidic flocculant is added to the copper sulfate solution to acidify the water and promote dissolving of the copper sulfate in the water. A 25-50% water solution of an acidic flocculant, with or without a cationic polymeric flocculant aid, is prepared and pumped into a processing vessel or tank. The acidified copper sulfate solution is added to the tank and mixed with the acidic flocculant. The algicide-flocculant solution is transported to a municipal water plant and added to raw water in the clarifier to drop out particulates in the incoming water and control algae in the clarifier.Type: GrantFiled: April 6, 1998Date of Patent: June 19, 2001Assignee: Bay Chemical and Supply CompanyInventors: Thomas J. Nier, Tosby L. Linn
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Patent number: 6245758Abstract: The present invention provides a method for the treatment of diseases by the decomposition of peroxynitrite, preferably decomposition to benign products, comprising the use of a complex which is a selected ligand structure providing a complexed metal such as Mn, Fe, Ni and V transition metals. The method of use, as well as novel pharmaceutical compositions therefor, are for the treatment of diseases advantageously affected by decomposition of peroxynitrite ed at a rate over the natural background rate of decay of peroxynitrite in humans suffering from the disease which comprises administration of an amount of a complex, in dosage unit form, which is effective for such acceleration of the decomposition of peroxynitrite .Type: GrantFiled: September 9, 1996Date of Patent: June 12, 2001Inventors: Michael K. Stern, Daniela Salvemini
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Patent number: 6245360Abstract: A single entity product is provided for administration to persons being treated for nutritional deficiencies associated with addiction to alcohol, wherein the product is an extended-release multivitamin with minerals and trace elements in beneficial dose ranges and specifically contains thiamine and folic acid in the desired amounts of about 100 mg and 1 mg, respectively. The product may also contain riboflavin in an amount between about 1 mg and about 3 mg, pyridoxine in an amount between about 1 mg and about 3 mg, cyanocobalamin in an amount between about 6 mg and about 12 mg, biotin in an amount between about 10 mcg and about 50 mcg, niacin in an amount between about 10 mg and about 50 mg, vitamin D in an amount between about 200 IU and about 500 IU, vitamin E in an amount between about 10 IU and about 50 IU, selenium in an amount between about 5 mcg and about 50 mcg, and/or magnesium in an amount between about 100 mg and about 400 mg.Type: GrantFiled: June 25, 1999Date of Patent: June 12, 2001Inventor: John S. Markowitz
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Patent number: 6218438Abstract: Compositions for delivery having a biological agent or derivative thereof, and a poly(oxyethylene)-poly(oxypropylene) block copolymer. The compositions are useful in immunodeficiency infection virus therapy. The invention also encompasses methods of treatment using the same.Type: GrantFiled: November 17, 1999Date of Patent: April 17, 2001Assignee: Supratek Pharma, Inc.Inventors: Valery Alakhov, Alexander Kabanov, Michael Parniak, Evgueni Klinski
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Patent number: 6197815Abstract: Metal amino acid chelates for animals are beneficial for facilitating and promoting growth by increasing desired metallic ion uptake. The present invention is directed to a process for providing an animal fed additive by preparing metal amino acid chelates, and the metal amino acid chelate growth facilitator, promoter and enhancer prepared by the process.Type: GrantFiled: March 18, 1998Date of Patent: March 6, 2001Assignee: J.H. Biotech, Inc.Inventor: Hsinhung John Hsu
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Patent number: 6193950Abstract: Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.Type: GrantFiled: February 22, 2000Date of Patent: February 27, 2001Assignee: Schering AGInventors: Johannes Platzek, Heribert Schmitt-Willich, Heinz Gries, Gabriele Schuhmann-Giampieri, Hubert Vogler, Hanns-Joachim Weinmann, Hans Bauer
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Patent number: 6183724Abstract: Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.Type: GrantFiled: September 17, 1998Date of Patent: February 6, 2001Assignee: Schering AktiengesellschaftInventors: Johannes Platzek, Heribert Schmitt-Willich, Heinz Gries, Gabriele Schumann-Giampieri, Hubert Vogler, Hanns-Joachim Weinmann, Hans Bauer
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Patent number: 6150547Abstract: This invention provides carbonic acid- and/or hydrogencarbonic acid-iron-hydrolyzates of casein complexes containing a large amount of iron, without causing precipitation after heating their aqueous solution or astringent taste and the processes for production thereof. The complexes of the present invention are prepared by (1) partial hydrolysis of carbonic acid- and/or hydrogencarbonic acid-iron-casein complexes with a protease or (2) mixing carbonic acid and/or hydrogencarbonic acid, iron and partial hydrolyzates of casein with a protease. These complexes are used favorably as food additives, raw materials of medicines or feed components due to their lack of precipitation by heating their aqueous solution, or astringent taste.Type: GrantFiled: November 20, 1998Date of Patent: November 21, 2000Assignee: Snow Brand Milk Products Co., Ltd.Inventors: Toshio Sakurai, Akihito Ikenaga, Taishi Oda, Toshiaki Uchida, Akira Tomizawa, Hitoshi Aikawa, Ken Takahashi
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Patent number: 6146615Abstract: A compound of formula (I): ##STR1## wherein, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are selected independently from hydrogen, alkyl, and alkyl substituted with one or more --O-- atoms, or where R.sup.1, R.sup.2 and R.sup.3, R.sup.4 are ring residues. The compound is capable of functioning as a ligand and complexing with paramagnetic Fe(III) ion for use as a second-sphere contrast enhancing agent for magnetic resonance imaging of tissue, and a method of administering the second sphere contrast agent.Type: GrantFiled: January 11, 1999Date of Patent: November 14, 2000Assignees: The University of Toledo, Schering AktiengesellschaftInventors: Julian A. Davies, Wolfgang Ebert, Bernd Raduechel
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Patent number: 6114379Abstract: A chelate comprised of creatine bonded to an essential mineral selected from the group consisting of Mg, Ca, Cu, Zn, Fe, Cr, Co, Mo, Se and Mn to form a heterocyclic ring. Preferably, the metal is Mg, but Ca, Zn, Fe, Cr and Mn are also preferred. The creatine chelates of the present invention are capable of being absorbed in the stomach or intestines via active transport without substantial metabolism of the chelate. In other words, the creatine ligand is protected by the metal from undergoing cyclization in the acidic environment of the stomach and the metal is made more bioavailable due to the presence of the creatine ligand.Type: GrantFiled: July 7, 1999Date of Patent: September 5, 2000Assignee: Albion Laboratories, Inc.Inventors: David C. Wheelwright, Stephen D. Ashmead
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Patent number: 6099824Abstract: Compounds which can chelate paramagnetic bi- and trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI), the compounds having formula (I) ##STR1## wherein R is a --(CH.sub.2).sub.m --O--R.sub.2 group or hydrogen,R.sub.2 is a (C.sub.6 -C.sub.10) aryl, or an alkyl(C.sub.1 -C.sub.5)-aryl(C.sub.6 -C.sub.10) group, substituted or not by a group L corresponding to a OH group or a OR.sub.3 group, wherein R.sub.3 is a linear or branched (C.sub.1 -C.sub.5) alkyl group; or L is NH.sub.2, halogen, COOH or CONR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 are independently hydrogen, or a linear or branched (C.sub.1 -C.sub.5) alkyl which can be substituted by 1-6 hydroxy groups and/or 1-6 alkoxy groups,R.sub.1 can have the same meanings as R, independently from it, except for hydrogen,Z is independently OH or OR.sub.6, or NR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 are as previously defined, and R.sub.6 is a (C.sub.1 -C.sub.Type: GrantFiled: August 1, 1997Date of Patent: August 8, 2000Assignee: Dibra S.p.A.Inventors: Pier Lucio Anelli, Andrea Beltrami, Fulvio Uggeri, Mario Virtuani
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Patent number: 6093416Abstract: A stomach-action molluscicide including a metal complexone as an active ingredient. The term "complexone" as used herein refers to an organic ligand containing at least one iminodiacetic group --N(CH.sub.2 CO.sub.2 H.sub.2).sub.2 or two aminoacetic groups --NHCH.sub.2 CO.sub.2 H which form stable complexes with most cations. Preferably, the complexone is a derivative of ethylenediaminetetraacetic acid.Type: GrantFiled: February 18, 1998Date of Patent: July 25, 2000Inventor: Colin Leslie Young
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Patent number: 6086923Abstract: The present invention is directed to a method of inhibiting the growth of disease organisms on and in plants by directly applying an aqueous solution comprising urea and at least one water-soluble salt of a divalent cation and a monovalent anion to the seeds, stems, bark, leaves, seed heads or sub-surface root zones of said plants. The weight percent ratio of urea to divalent cation in these solutions should be from about 0.25-10.0 to 1.0. Preferred divalent cations include those of the alkaline earth metals and the transition metals. Most preferred are calcium, magnesium, zinc, manganese, copper, iron, cobalt, nickel and mixtures thereof. Preferred anions include nitrate, chloride, bromide and mixtures thereof. In more preferred solutions, the ratio of urea to divalent cation is from about 2.0-7.0 to 1.0. Particularly preferred solutions include calcium chloride as the water-soluble salt. Optionally, a second water-soluble salt of a divalent cation and a monovalent anion may be included.Type: GrantFiled: March 31, 1997Date of Patent: July 11, 2000Assignee: Stoller Enterprises, Inc.Inventor: Jerry Herman Stoller
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Patent number: 6054117Abstract: Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.Type: GrantFiled: September 17, 1998Date of Patent: April 25, 2000Assignee: Schering AktiengesellschaftInventors: Johannes Platzek, Heribert Schmitt-Willich, Heinz Gries, Gabriele Schuhmann-Giampieri, Hubert Vogler, Hanns-Joachim Weinmann, Hans Bauer
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Patent number: 6046188Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.Type: GrantFiled: March 11, 1998Date of Patent: April 4, 2000Assignee: Eukarion, Inc.Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
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Patent number: 6020369Abstract: Respiratory viral infections may be effectively prevented or treated by administering an aerosol spray comprising a polyoxometalate to the lungs.Type: GrantFiled: July 7, 1998Date of Patent: February 1, 2000Inventors: Raymond F. Schinazi, Craig L. Hill
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Patent number: 5955053Abstract: The present invention relates to novel metal chelates, exemplified as technetium-99m or rhenium chelates, and to the process of preparing such metal chelates from corresponding ligands. These ligands and their corresponding metal chelates are synthesized to have a cysteinylethylene (EC) structure, a thioacetamidethiourea (TATU) structure, or a dithiourea (DTU) structure. The present invention further relates to a pharmaceutical composition comprising a metal chelate, for example, a .sup.99m Tc-chelate, to the use of the composition for renal imaging and examination of renal function, and to a kit for preparing such a composition prior to use.Type: GrantFiled: May 6, 1996Date of Patent: September 21, 1999Assignee: Emory UniversityInventors: Luigi Gaetano Marzilli, Malgorzata Lipowska, Lory Hansen, Andrew Taylor, Jr.
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Patent number: 5948443Abstract: The present invention pertains generally to the field of Public Health, including the prevention and treatment of coronary heart disease which is currently the first cause of death in the American population. More specifically, the present invention concerns a total modular system of multivitamin and mineral supplementation composed of 7 distinct modules for improving public health by insuring adequate intake of micronutrients needed for disease prevention and protection against nutritional losses and deficiencies due to, for example, lifestyle factors and common inadequate dietary patterns. A module, as used herein throughout, is defined as a separate and distinct combination of vitamin-mineral and other health promoting compounds which are directed to specific target populations. The formulations of the present invention which, when combined in one capsule or tablet or as separate modules, exert a joint and enhancing effect on the major pathogenetic factors involved in the atherosclerotic process.Type: GrantFiled: February 21, 1997Date of Patent: September 7, 1999Assignee: Medical Doctor's Research Institute, Inc.Inventors: Patricia A. Riley, George Christakis
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Patent number: 5916356Abstract: This invention relates to preservative compositions which comprise a biocidal metal compound and an fungicidal compound containing a triazole group. Methods of treating wood with the composition are also described.Type: GrantFiled: June 2, 1997Date of Patent: June 29, 1999Assignee: Hickson International PLCInventors: Gareth Williams, Judith Ann Cornfield, Janet Brown, Neil Patrick Ryan
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Patent number: 5914095Abstract: There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g. DOTA residues, conjugated to a dendritic polyamine backbone molecule, e.g. a starburst dendrimer. To produce a site-specific polychelate, one or more of the macrocyclic chelant carrying backbone molecules may be conjugated to a site-directed macromolecule, e.g. a protein.Type: GrantFiled: October 7, 1991Date of Patent: June 22, 1999Assignee: Salutar, Inc.Inventor: Alan D Watson
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Patent number: 5914097Abstract: The present invention relates to the preparation of amino-acyl-type and catecholamine-type compounds having multiple carboxylic acid functional groups. Paramagnetic metal (II) or (III) ion chelate complexes are formed using these compounds for use as intravenous contrast agents to produce enhanced contrast magnetic resonance images of the heart, liver, biliary tree or upper small intestine. The mono- and di-amino acids, their esters and amides, and catecholamine-like derivatives, of EDTA, DTPA, and the like are prepared. The paramagnetic metal (II) or (III) ion complexes are formed and produce T1-related contrast effects in MR images. The compounds and complexes also appear to have low toxicities and to be relatively rapidly and completely cleared from the tissue of a living mammal, e.g. a human being.Type: GrantFiled: June 6, 1995Date of Patent: June 22, 1999Assignee: Regents of the University of CaliforniaInventor: David L. White
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Patent number: 5911971Abstract: Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.Type: GrantFiled: November 4, 1996Date of Patent: June 15, 1999Assignee: Schering AktiengesellschaftInventors: Johannes Platzek, Heribert Schmitt-Willich, Heinz Gries, Gabriele Schuhmann-Giampieri, Hubert Vogler, Hanns-Joachim Weinmann, Hans Bauer
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Patent number: 5910510Abstract: Photodynamic therapy of conditions of the eye, especially those conditions characterized by unwanted neovasculature, such as age-related macular degeneration, results in enhanced visual acuity for treated subjects.Type: GrantFiled: May 22, 1998Date of Patent: June 8, 1999Assignee: QLT Phototherapeutics IncInventors: H. Andrew Strong, Julia Levy, Gustav Huber, Mario Fsadni
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Patent number: 5906978Abstract: The invention relates to methods and compositions for delivering iron to an iron-deficient patient, more particularly, to methods whereby an iron complex comprising divalent or trivalent ionic iron complexed with one or more low molecular weight anions is administered to a patient by transfer from dialysate. A complex selected according to the invention is non-polymeric; soluble in an aqueous medium; chemically stable, thereby preventing the dissociation of iron ions from the anions under conditions according to the invention; and can be well absorbed into blood and the living body. Also provided are dialysate compositions including therein an iron complex selected according to the invention, and dialysate concentrates which may be diluted to yield an inventive dialysate composition.Type: GrantFiled: June 5, 1997Date of Patent: May 25, 1999Assignee: Hemocleanse, Inc.Inventor: Stephen R. Ash
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Patent number: 5889053Abstract: Novel farnesyl transferase inhibitors of general formula (I), ##STR1## the preparation thereof and pharmaceutical compositions containing said inhibitors, are disclosed. In general formula (I), R.sub.1 is Y--S--A.sub.1 (where Y is a hydrogen atom, an amino acid residue, a fatty acid residue, an alkyl or alkoxycarbonyl radical or a radical R.sub.4 --S-- where R.sub.4 is a C.sub.1-4 alkyl radical optionally substituted by a phenyl radical or a radical of general formula (II) ##STR2## wherein A.sub.1, X, X.sub.1, Y.sub.1, R'.sub.1, R.sub.2, R'.sub.2 and R are defined as below, and A.sub.1 is a C.sub.1-4 alkylene radical optionally alpha-substituted in the >C(X.sub.1)(Y.sub.1) grouping by an amino or alkylamino, dialkylamino, alkanoylamino or alkoxycarbonylamino radical); X.sub.1 and Y.sub.1 are each a hydrogen atom or, taken together with the carbon atom to which they are attached, form a >C.dbd.O grouping; R'.sub.1 is hydrogen or a C.sub.1-6 alkyl radical; X is an oxygen or sulphur atom; R.sub.2 is a C.Type: GrantFiled: January 9, 1998Date of Patent: March 30, 1999Assignee: Rhone-Poulenc Rorer S.A.Inventors: Bernard Baudoin, Christopher Burns, Alain Commercon, Alain Lebrun
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Patent number: 5863911Abstract: Diarylethylene metallocene derivatives, processes for preparing the same and pharmaceutical compositions which contain the derivatives are disclosed. The compounds of the invention can exhibit anti-tumor activity, and can be particularly useful in the treatment of estrogen-dependent cancers.Type: GrantFiled: August 11, 1997Date of Patent: January 26, 1999Assignee: Modelisation et Mise au Point de Molecules MedicinalesInventors: Gerard Jaouen, Siden Top
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Patent number: 5824706Abstract: Respiratory viral infections may be effectively prevented or treated by administering an aerosol spray comprising a polyoxometalate to the lungs.Type: GrantFiled: March 3, 1995Date of Patent: October 20, 1998Inventors: Raymond F. Schinazi, Craig L. Hill
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Patent number: 5807586Abstract: The present invention relates to a method of supplementing the dietary needs of women whereby an effective amount of a life stage appropriate dietary supplement is administered to a woman at each of her life stages throughout her life.Type: GrantFiled: July 30, 1996Date of Patent: September 15, 1998Assignee: Energetics, Inc.Inventors: Sherry D. Jackson, Jeffrey B. Blumberg
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Patent number: 5804164Abstract: The present invention relates to water-soluble, lipophilic contrast-enhancing agents, pharmaceutical compositions thereof and methods for diagnostic analysis, particularly NMR or MRI analysis using these contrast-enhancing agents. The water-soluble, lipophilic contrast-enhancing agents are chelates of a paramagnetic, ferromagnetic or diamagnetic metal ion(s) complexed with completing acids which contain at least one short-chain fatty acyl moiety having from about 0 to about 6 carbon atoms in its structure.Type: GrantFiled: March 13, 1996Date of Patent: September 8, 1998Assignee: Research Corporation Technologies, Inc.Inventor: Gabriel A. Elgavish