C=o Other Than As Ketone Or Aldehyde Patents (Class 514/521)
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Patent number: 12036312Abstract: The present invention relates to non-aqueous topical compositions comprising a halogenated salicylanilide and the use of such compositions in the topical treatment or prevention of diseases and infections, particularly conditions caused by Gram-positive bacteria, for example the topical treatment or prevention of skin infections such as acne, atopic dermatitis and impetigo. Also disclosed are methods for preparing the gel composition.Type: GrantFiled: March 15, 2017Date of Patent: July 16, 2024Assignees: UNION THERAPEUTICS A/S, KØBENHAVNS UNIVERSITET (UNIVERSITY OF COPENHAGEN)Inventors: Morten Otto Alexander Sommer, Ping Li, Camilla Hasling Frandsen, Hanne Mørck Nielsen, Petra Alexandra Priemel, Thomas Rades
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Patent number: 11961638Abstract: A cable includes a pair of conductors extending longitudinally and spaced apart from each other, an inner insulating layer circumferentially wrapped around an outside of the conductors and fixing the conductors, a conductive shielding layer circumferentially wrapped around an outside of the inner insulating layer, and an outer insulating layer circumferentially wrapped around an outer peripheral surface of the conductive shielding layer. At least one of the conductive shielding layer and the outer insulating layer includes a pair of diametrically opposed circumferential halves. Each circumferential half surrounds a part of a circumference of the inner insulating layer and extends longitudinally.Type: GrantFiled: October 7, 2022Date of Patent: April 16, 2024Assignee: Tyco Electronics (Shanghai) Co., Ltd.Inventors: Zhiwei (Jack) Guo, Hainan (Harlan) Lu
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Patent number: 11877994Abstract: Methods of treating or ameliorating multiple sclerosis by the dihydroorotate dehydrogenase (DHODH) inhibitor vidofludimus or a pharmaceutically acceptable salt and/or a solvate, in particular a hydrate, thereof or a solvate, in particular a hydrate, of a pharmaceutically acceptable salt thereof, by administering to a human patient a therapeutically effective amount of the DHODH inhibitor, more specifically a daily dose of about 10 mg to about 45 mg.Type: GrantFiled: August 2, 2021Date of Patent: January 23, 2024Assignee: IMMUNIC AGInventors: Andreas Mühler, Hella Kohlhof, Daniel Vitt
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Patent number: 11771663Abstract: The present invention is directed to epinephrine spray formulations. The present invention is further directed to methods of treating anaphylaxis by administering epinephrine spray formulations to subjects in need of such treatments.Type: GrantFiled: March 2, 2021Date of Patent: October 3, 2023Assignee: Hikma Pharmaceuticals USA Inc.Inventors: Thrimoorthy Potta, Craig Bastian, Ningxin Yan, Venkat Goskonda, Chandeshwari Chilampalli, Rachana Inavolu, Eshwaran Narayanan
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Patent number: 11213502Abstract: Disclosed is a method for the treatment of a neurological or movement disorder, e.g., Parkinson's disease, in an individual in need thereof, by parenteral administration of levodopa and a dopa decarboxylase inhibitor (DDCI), such as carbidopa, benserazide or any combination thereof, concomitantly with oral administration of levodopa, a DDCI, such as carbidopa, benserazide, or any combination thereof.Type: GrantFiled: May 28, 2021Date of Patent: January 4, 2022Assignee: NeuroDerm, Ltd.Inventors: Tal Birnberg, Liat Adar, Itay Perlstein
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Patent number: 11096934Abstract: The present invention includes methods of treating patients with acute myeloid leukemia across a range of genetic subtypes with DHODH inhibitors, such as 6-fluoro-2-(2?-fluoro-[1,1?-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid).Type: GrantFiled: August 29, 2016Date of Patent: August 24, 2021Assignees: THE BROAD INSTITUTE, INC., THE GENERAL HOSPITAL CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, BAYER PHARMA AKTIENGESELLSCHAFTInventors: David B. Sykes, David Scadden, Timothy A. Lewis, Andreas Janzer, Hanna Meyer, Detlef Stöckigt
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Patent number: 10980767Abstract: Provided are compounds and methods for treating neurodegenerative diseases and conditions, such as multiple sclerosis, using an estrogen receptor-? ligand (ER? ligand).Type: GrantFiled: September 8, 2017Date of Patent: April 20, 2021Assignee: The Regents of the University of CaliforniaInventors: Michael E. Jung, Rhonda R. Voskuhl
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Patent number: 10517826Abstract: A pharmaceutical composition based on Anthostema senegalense is used as a drug in the treatment of HIV infection, AIDS and accompanying clinical manifestations. The composition can be used as an antiretroviral drug against HIV type 1 or HIV type 2. The composition includes polar and/or apolar plant extract of Anthostema senegalense, preferable obtained from the stem bark of Anthostema senegalense. The composition is preferably formulated in the form of microspheres produced using an extrusion and spheronization method, and then grouped together in capsules.Type: GrantFiled: February 20, 2015Date of Patent: December 31, 2019Assignee: LABORATOIRE MICHEL IDERNEInventor: Aliou Mamadou Balde
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Patent number: 9611404Abstract: A method of making a sacrificial coating composition is disclosed. The method comprises emulsifying an oil with surfactant to form an oil-in-water emulsion; and combining ingredients comprising (i) at least one polymer, (ii) at least one hygroscopic material, (iii) the oil-in water emulsion and (iv) water to produce the sacrificial coating composition. The at least one polymer is selected from the group consisting of a hydrophilic polymer, a latex comprising polymer particles dispersed in a continuous liquid phase, or mixtures thereof.Type: GrantFiled: September 23, 2014Date of Patent: April 4, 2017Assignee: XEROX CORPORATIONInventors: Gordon Sisler, Guiqin Song, Brynn Dooley, Marcel P. Breton, Suxia Yang
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Patent number: 9572346Abstract: The invention relates to an octanoic, nonanoic and decanoic (C8, 9, 10) fatty acids mixture with a pyrethroid. The invention also relates to methods of using the octanoic, nonanoic and decanoic (C8, 9, 10) fatty acids and pyrethroid mixture to achieve superior arthropod control.Type: GrantFiled: October 2, 2014Date of Patent: February 21, 2017Assignee: Valent BioSciences CorporationInventors: Benjamin A. Belkind, Jason Clark, Peter DeChant
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Patent number: 9309378Abstract: A polyacrylamide-based composition as a microemulsion is provided in the form of a water-in-oil microemulsion with polyacrylamide dissolved in the water phase, and further comprising ethylene oxide-propylene oxide block copolymer. Specifically, the present invention includes, dissolved in the water phase, a polyacrylamide copolymer and an EO/PO block copolymer, with the water phase mixed with an oil phase. Preferably, the present invention may further comprise the presence of at least one fatty acid and/or at least one nonionic surfactant to stabilize the microemulsion. In addition, the present invention may further comprise effective amount of other components, such as pesticides and/or fertilizers, that may be delivered to trees, plants or other vegetation.Type: GrantFiled: April 21, 2011Date of Patent: April 12, 2016Assignee: Exacto, Inc.Inventors: Franklin E. Sexton, Todd J. O'Connell, Ryan T. Strash
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Patent number: 9290445Abstract: Methods of synthesizing a levodopa ester prodrug, salts thereof, and synthetic intermediates thereof are disclosed.Type: GrantFiled: October 19, 2009Date of Patent: March 22, 2016Assignee: XenoPort, Inc.Inventors: Stephen P. Raillard, Adam Mann, Suresh K. Manthati, Randall A. Scheuerman, Tono Estrada, Mark Q. Nguyen, Cindy X Zhou
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Patent number: 9226507Abstract: The current invention provides a kit of parts for producing an emulsifiable pesticide solution comprising: (a) a water miscible organic solvent selected from the list of a glycol ether, a glycerol formal, dimethylsulfoxide, gamma-butyrolactone or mixtures thereof, (b) an alkoxylated alcohol with an average of 6 to 80 moles of ethylene oxide and 2 to 60 moles of propylene oxide per mole of alcohol; and (c) a pesticidal active ingredient. The invention further provides a composition for producing an emulsifiable pesticide solution, a method for producing such a composition and a method for treating an agricultural crop. In addition the invention provides some advantageous pesticidal compositions.Type: GrantFiled: July 19, 2012Date of Patent: January 5, 2016Inventor: Alan Pirotte
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Patent number: 9204630Abstract: An encapsulated composition of (a) a pesticide at least active via ingestion that is photolabile, and (b) at least one photoprotectant, wherein the encapsulating polymeric barrier is base triggerable is disclosed. A method for controlling damage of a material by a pest by the use of such encapsulated compositions is likewise disclosed. The composition as disclosed gives protection for beneficial arthropods and reduces workers exposure.Type: GrantFiled: February 23, 2006Date of Patent: December 8, 2015Assignee: Syngenta Participations AGInventors: Ian Malcolm Shirley, Tanya Wright, Robert Michael Perrin, Patrick Mulqueen, Anne Waller, Andy Pierce
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Patent number: 9149416Abstract: The present invention provides an insecticidal emulsion cleansing system comprising a clear oil-in-water (o/w) emulsion wherein the oil phase contains an ionic surfactant and an insecticide suspended together as nanometer sized particles in the water phase; and wherein the water phase contains an oppositely charged polymer. The insecticide is preferably a pyrethroid such as a natural pyrethrin or a synthetic pyrethroid. Suitable pyrethroids include pyrethroid esters and pyrethroid ethers.Type: GrantFiled: August 21, 2009Date of Patent: October 6, 2015Assignee: WELLMARK INTERNATIONALInventors: Min Xie, Robin Rudolph, Stephanie Ponder
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Patent number: 9139430Abstract: Composite nanogranules from polymer/inorganic nanoparticle, especially first composite nanogranules which are formed from first polymer and inorganic nanoparticles, second composite nanogranules which are obtained by forming second polymer on the first composite nanogranules, third composite nanogranules which is obtained by forming third polymer on the second composite nanogranules, and Nth composite nanogranules which is obtained by forming Nth polymer on the (N?1)th composite nanogranules with the similar method, are disclosed. A composition comprising anyone of the composite nanogranules described above is disclosed. The preparation method thereof and use of the same are also disclosed.Type: GrantFiled: May 12, 2010Date of Patent: September 22, 2015Assignee: Wuxi Now Materials Corp.Inventors: Suping Qian, Yuhong Xu, Zhentian Fan, Yongtai Hou
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Patent number: 9040578Abstract: Provided herein, in part, is a method of treating a neurological or movement disorder in a patient in need thereof, comprising subcutaneously administering to said patient a pharmaceutically acceptable composition comprising levodopa and optionally carbidopa and optionally entacapone or tolcapone, or pharmaceutically acceptable salts thereof, wherein said composition is administered substantially continuously, and compositions that can be used in the disclosed methods.Type: GrantFiled: April 2, 2014Date of Patent: May 26, 2015Assignee: NeuroDerm, Ltd.Inventors: Oron Yacoby-Zeevi, Mara Nemas
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Patent number: 9040577Abstract: Provided herein, in part, is a method of treating a neurological or movement disorder in a patient in need thereof, comprising subcutaneously administering to said patient a pharmaceutically acceptable composition comprising levodopa and optionally carbidopa and optionally entacapone or tolcapone, or pharmaceutically acceptable salts thereof, wherein said composition is administered substantially continuously, and compositions that can be used in the disclosed methods.Type: GrantFiled: April 2, 2014Date of Patent: May 26, 2015Assignee: NeuroDerm, Ltd.Inventors: Oron Yacoby-Zeevi, Mara Nemas
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Publication number: 20150140056Abstract: The present disclosure relates to water dispersible granular pesticide compositions, and methods of making and using the compositions. The pesticide compositions include an inner layer including a first pesticide coated on to a substrate, and an outer layer comprising a second pesticide coated on the inner layer. The outer layer increases the water dispersibility of the granular composition, and protects the first pesticide against hydrolysis and photolysis.Type: ApplicationFiled: January 23, 2015Publication date: May 21, 2015Inventors: Victor F. Man, Yvonne M. Killeen, Susan M. Viall
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Publication number: 20150132260Abstract: The present invention relates to the use of the measure of anelloviral load for the determination of immunosuppression. More precisely, the present invention provides a method for characterizing the immunosuppressed or non-immunosuppressed status of a subject, comprising the steps of determining the anelloviral load from a biological sample of the said subject, and determining from the said comparison the immunosuppressed or non-immunosuppressed status. The determination of the immunosuppressed status of the subject can then be used to design or adapt a therapeutic treatment.Type: ApplicationFiled: April 19, 2013Publication date: May 14, 2015Inventors: Marc Eloit, Justine Cheval, Charles Hebert, Marc Lecuit
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Publication number: 20150126591Abstract: The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of Parkinson's disease may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be also used for the treatment of Huntington's disease, Alzheimer's disease, Multiple Sclerosis, Lateral Sclerosis, Neural Motor disorders.Type: ApplicationFiled: March 21, 2013Publication date: May 7, 2015Inventor: Mahesh Kandula
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Patent number: 9011889Abstract: The present invention relates to an insecticide-containing polymeric material containing at least one embedded insecticidally active ingredient in the polymeric matrix and having excellent biological activity, and also to the products produced from this polymer and to their use for protecting humans, animals and plants against arthropods, particularly for controlling insects.Type: GrantFiled: April 14, 2011Date of Patent: April 21, 2015Assignee: Bayer CropScience AGInventors: Maren Heinemann, Thomas Böcker, Karin Horn, Guenther Nentwig, Rainer Sonneck, Thomas König
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Publication number: 20150104417Abstract: The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.Type: ApplicationFiled: May 29, 2013Publication date: April 16, 2015Inventors: Elke Hellwege, Wolfram Andersch, Klaus Stenzel, Bernd Springer
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Publication number: 20150094343Abstract: The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as inhibitors of Jak2/STAT3 pathways and downstream targets and inhibit the growth and survival of cancerous cell lines.Type: ApplicationFiled: June 4, 2014Publication date: April 2, 2015Applicant: The Board of Regents of the University of Texas SystemInventors: Waldemar PRIEBE, Izabela FOKT, Slawomir SZYMANSKI, Timothy MADDEN, Jeffrey MYERS, Charles CONRAD
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Publication number: 20150087517Abstract: The present disclosure relates to the manufacturing of specifically targeting microcapsules comprising agrochemicals. More specifically, the disclosure relates to specifically targeting microcapsules, to which targeting agents are covalently linked at a ratio from about 0.01 ?g-to about 1 ?g targeting agents per square centimeter of the surface of the microcapsule, such that the microcapsules are capable of binding the agrochemicals contained in the microcapsules to a surface, and to agrochemical compositions comprising such microcapsules.Type: ApplicationFiled: October 8, 2012Publication date: March 26, 2015Inventors: Peter Verheesen, Chris De Jonghe
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Patent number: 8975292Abstract: The present invention relates to a method for controlling arthropods comprising the application of an aqueous gel which contains an insecticide, an attractant and a thickener, wherein the aqueous gel is applied in the form of spots on fruit trees. The invention further relates to an aqueous gel comprising an insecticide, an attractant, a thickener, a humectant and a feeding stimulant. The invention also relates to a concentrated gel for preparing the aqueous gel.Type: GrantFiled: January 21, 2011Date of Patent: March 10, 2015Assignee: BASF SEInventors: Claude Taranta, Tatjana Levy, Ouidad Benlahmar, Marc Nolte, Thomas Kröhl, Christoph Randt, Thomas Bork, Wolfgang Meier, Clark D. Klein, Tiffany Hennessey
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Patent number: 8975296Abstract: The instant invention relates to pharmaceutical compositions containing cathespin K inhibitors. Also disclosed are processes for making said pharmaceutical compositions.Type: GrantFiled: March 20, 2013Date of Patent: March 10, 2015Assignee: Merck Sharp & Dohme Corp.Inventors: Haihong Fan, Majid Mahjour, Justin Moser, Bhagwant Rege
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Publication number: 20150065475Abstract: Oil-in-water fungicidal formulations are prepared having pigment dispersed therein, the pigment being stable within the oil-in-water emulsion as a result of the addition of suitable silicone surfactants and suitable emulsifiers. The formulations can be prepared either as a 2-pack formulation or as a single formulation. In the case of the single formulation polyethylene glycol is also added. In either case, the formulations show a synergistic effect through the addition of the pigment, the resulting formulations having an increased efficacy. Further, the formulations show a synergistic effect when mixed with conventional chemical fungicides, both being added in reduced amounts compared to recommended rates.Type: ApplicationFiled: September 9, 2014Publication date: March 5, 2015Inventors: Michael Fefer, Jun Liu, Tomoki Ruo, Sonia Edith Hevia
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Publication number: 20150056257Abstract: The present invention relates to a method for preparing an emulsifiable granule comprising the steps of a) emulsifying water with a solution of a pesticide in a water-insoluble solvent, b) contacting the emulsion resulting from step a) and a solid dispersant containing a water-soluble polycarboxylate and a water-soluble anionic surfactant, and c) extruding the paste resulting from step b). The invention further relates to emulsifiable granules containing a water-insoluble solvent, a pesticide, which is dissolved in the water-insoluble solvent, a water-soluble polycarboxylate, and a water-soluble anionic surfactant.Type: ApplicationFiled: February 26, 2013Publication date: February 26, 2015Inventors: Claude Taranta, Thomas Bork, Jochen Schreieck, Helmut Mueller, Nadine Riediger, Clark D. Klein, Rebecca Willis, Tatjana Sikuljak, Simon Nord
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Patent number: 8962681Abstract: The present invention relates to a method of treating a parasitic infection in an animal, particularly a filarial endoparasitic infection, comprising administering an effective amount of a Formula (I) compound or a Formula (II) compound stereoisomer thereof, or veterinarily acceptable salt of said compound or stereoisomer thereof, or in combination with at least one additional veterinary agent, wherein: R1, R2, R3, R4, R5, R1a, R1b, R1c, R1d, R1e are as described herein.Type: GrantFiled: October 8, 2012Date of Patent: February 24, 2015Assignee: Zoetis LLCInventors: George Anthony Conder, Kevin Evans, Patrick F. M. Meeus, Debra Jean Woods
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Patent number: 8957098Abstract: The invention relates to the use of polycycloolefins in electronic devices and more specifically to the use of such polycycloolefins as interlayers applied to insulating layers used in electronic devices, the electronic devices that encompass such polycycloolefin interlayers and processes for preparing such polycycloolefin interlayers and electronic devices.Type: GrantFiled: August 23, 2011Date of Patent: February 17, 2015Assignee: ALGIAX Pharmaceuticals GmbHInventors: Guido Koopmans, Birgit Hasse, Stefan Mullner
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Publication number: 20150044149Abstract: The present disclosure relates, according to some embodiments, to molecules, including substituted propenoic amides (e.g., aryl substituted propenoic amides), that may receive excited state energy from light-absorbing molecules. According to some embodiments, the present disclosure relates to molecules, including substituted propenoic amides (e.g., aryl substituted propenoic amides), that may quench, dissipate, and/or otherwise resolve excited state energy (e.g., as heat).Type: ApplicationFiled: August 5, 2014Publication date: February 12, 2015Inventors: Craig Bonda, Shengkui Hu, Gary A. Neudahl, Stephen O'Rourke, Stephen J. Semlow, Zhihui Zhang
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Publication number: 20150045358Abstract: A pharmaceutical composition for treating disorders associated with insulin resistance is disclosed, and the composition comprises at least one inhibitor which is an effective agent to suppress endothelin-1-stimulated resistin gene expression through decreasing the endothelin-1-stimulated phosphorylation of proteins downstream of endothelin type A receptor, wherein the downstream signaling molecules comprise ERK1/2, JNKs, AKT, and STAT3 proteins, and wherein the inhibitor is selected from at least one antagonist of the endothelin type A receptor or downstream signaling proteins.Type: ApplicationFiled: May 21, 2013Publication date: February 12, 2015Inventors: Yung-hsi KAO, Ya-chu Tang, Hsin-huei Chang, Hui-chen Ku
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Patent number: 8952031Abstract: The invention provides amino- and amido-aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, and n are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.Type: GrantFiled: March 5, 2012Date of Patent: February 10, 2015Assignee: Theravance Biopharma R&D IP, LLCInventors: Sean G. Trapp, Michael R. Leadbetter, Daniel D. Long, Lan Jiang, Sabine Axt
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Publication number: 20150038466Abstract: The present invention relates to the use of compounds for the treatment or prevention of pain in mammals, in particularly in human beings, and also to a process for preparing these compounds.Type: ApplicationFiled: December 31, 2012Publication date: February 5, 2015Inventors: Sylvie Ducki, Khalil Bennis, Alain Eschalier, Jérôme Busserolles, Florian Lesage, Nuno Rodriguez, Delphine Vivier
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Publication number: 20150025042Abstract: Disclosed are compounds of formulae (I), (III), (IV), (VII), (X), (XI), (XII), (XIII) and (XIV), wherein the variables are as defined in the claims, and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.Type: ApplicationFiled: December 16, 2013Publication date: January 22, 2015Applicant: SYNTA PHARMACEUTICALS CORP.Inventors: Shoujun Chen, Keizo Koya, Zachary Demko, Lijun Sun
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Publication number: 20150005356Abstract: This invention relates to pharmaceutical compositions of epinephrine for delivery to the nasal mucosa and methods of treating a subject in acute severe anaphylaxis, bronchospasm or during cardiopulmonary resuscitation (CPR). The composition further comprising agents, that either prevent localized degradation of epinephrine or enhance its absorption in the nasal mucosa to counter anaphylactic effects, symptoms or complications in a subject.Type: ApplicationFiled: June 27, 2013Publication date: January 1, 2015Applicant: G2B PHARMA INC.Inventor: Nigel Ten Fleming
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Patent number: 8921320Abstract: A targeted osmotic lysis (TOL) of tumor cells that over-express voltage-gated sodium channels (VGSCs) has been developed that uses a combined therapy of a drug that blocks sodium, potassium-adenosine triphosphatase (Na+, K+-ATPase) that is then followed by an activation of VGSCs, for example, by electrical or pharmacological stimulation. Activation of VGSCs conducts sodium into the cancer cells in much greater amounts than non-cancer cells. Water follows this sodium gradient into the cancer cells, causing swelling and lysis. Because non-cancerous cells do not over-express VGSCs, less sodium and less water will enter the cells, and the non-cancerous cells will not lyse. This method is applicable to all cells that over-express VGSCs, including, but not limited to, highly invasive breast cancer, prostate cancer, small cell lung cancer, non-small cell lung carcinoma, lymphoma, mesothelioma, neuroblastoma, and cervical cancer.Type: GrantFiled: July 19, 2012Date of Patent: December 30, 2014Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Dennis J. Paul, Harry J. Gould
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Patent number: 8920846Abstract: A microcapsule in which a liquid droplet is coated with a resin, wherein in the droplet, a pesticidally active solid ingredient is suspended in a compound of formula (I), wherein R represents a C1-C5 alkyl group, is useful as a formulation of a pesticidally active solid ingredient.Type: GrantFiled: September 2, 2010Date of Patent: December 30, 2014Assignee: Sumitomo Chemical Company, LimitedInventors: Naoki Tsuda, Mayuko Ozawa
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Patent number: 8906398Abstract: The present invention relates to an insecticide-containing fabric containing at least one embedded insecticidally active ingredient in the polymeric matrix and having excellent wash resistance, and also to the products produced from this fabric and to their use for protecting humans, animals and plants against arthropods, particularly for controlling insects.Type: GrantFiled: April 14, 2011Date of Patent: December 9, 2014Assignee: Bayer CropScience AGInventors: Rainer Sonneck, Thomas Böcker, Karin Horn, Guenther Nentwig, Maren Heinemann, Thomas König
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Publication number: 20140329901Abstract: The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines.Type: ApplicationFiled: January 3, 2014Publication date: November 6, 2014Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Waldemar PRIEBE, Nicholas DONATO, Moshe TALPAZ, Slawomir SZYMANSKI, Izabela FOKT, Alexander LEVITZKI
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Patent number: 8871679Abstract: Fungicidal mixtures, comprising as active components 1) at least one 1-methylpyrazol-4-ylcarboxanilide of the formula I where R1?C1-C4-alkyl or C1-C4-haloalkyl, R2=hydrogen or halogen, X=hydrogen or halogen, Q=direct bond, a cyclopropylene or an anellated bicyclo[2.2.Type: GrantFiled: July 2, 2009Date of Patent: October 28, 2014Assignee: BASF SEInventors: Markus Gewehr, Ulf Groeger, Egon Haden, Michael Vonend
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Patent number: 8871806Abstract: Methods for reducing the incidence of flea allergy dermatitis (FAD) in a companion animal are disclosed, the methods directed to inhibiting blood feeding by ectoparasites on a companion animal. The methods of the present invention involve administering a pesticide composition comprising cyphenothrin to a companion animal, specifically dogs and cats, in doses and proportions which are parasiticidally effective against a variety of ectoparasites, and in formulations which are convenient for topical application to the animal's skin, preferably localized over a small surface area. Such methods are useful in preventing and/or reducing the incidence of flea allergy dermatitis.Type: GrantFiled: June 6, 2012Date of Patent: October 28, 2014Assignee: Sergeant's Pet Care Products, Inc.Inventor: Larry Nouvel
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Publication number: 20140315998Abstract: A pest control composition is provided having an excellent control effect on pests and containing an ester compound represented by the following formula (1) and diethyl adipate. A method is also provided for controlling pests including applying the pest control composition to pests or habitats of pests.Type: ApplicationFiled: December 12, 2012Publication date: October 23, 2014Inventor: Masahiro Yamada
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Patent number: 8865736Abstract: Compounds of formula (I) have antibacterial activity: wherein R represents hydrogen or 1, 2 or 3 optional substituents; W is ?C(R1)—; R1 is hydrogen and R2 is hydrogen, methyl, or fluorine; or R1 and R2 taken together are —CH2—, —CH2CH2, —O—, or, in either orientation, —O—CH2— or —OCH2CH2—; and R3 is a radical of formula -(Alk1)m-(Z)p-(Alk2)n-Q.Type: GrantFiled: November 28, 2011Date of Patent: October 21, 2014Assignee: Biota Scientific Pty LtdInventors: David Ryall Brown, Ian Collins, Lloyd George Czaplewski, David John Haydon
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Patent number: 8853266Abstract: This invention provides use of a SARM compound or a composition comprising the same in treating a variety of diseases or conditions in a subject, including, inter-alia, a diabetes disease, and/or disorder such as cardiovascular disease, atherosclerosis, cerebrovascular conditions, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy.Type: GrantFiled: April 13, 2007Date of Patent: October 7, 2014Assignee: University of Tennessee Research FoundationInventors: James T. Dalton, Duane D. Miller
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Publication number: 20140296297Abstract: The present invention concerns polymeric material containing at least an embedded insecticidally active ingredient and an additive, which are released at room temperature. It similarly concerns materials produced from this polymer, for example in the form of self-supporting film/sheet, threads, wovens, fabrics, textiles, nets, curtains and pellets. The invention further concerns processes for producing such polymeric material and also the use of the self-supporting film/sheet, threads, wovens, fabrics, textiles and nets and curtains produced from the material for protecting humans, animals and plants and buildings, machines and packaging against arthropods, particularly for controlling insects.Type: ApplicationFiled: June 9, 2014Publication date: October 2, 2014Inventors: Rainer SONNECK, Thomas BÖCKER, Karin HORN, Guenther NENTWIG, Maren HEINEMANN, Thomas KÖNIG
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Publication number: 20140294968Abstract: The invention relates to novel polyacrylate-based active compound-comprising particles which bind to hair, and to the use of these particles for preparing medicaments, in particular for veterinary medicine. The particles comprise uncharged and cationic polyacrylate and are at most 10 um big.Type: ApplicationFiled: July 23, 2012Publication date: October 2, 2014Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Stefan Hofmann, Claudia Selbach, Eva Maria Krüdewagen, Dorothee Stanneck
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Publication number: 20140296335Abstract: The present invention relates to the use of a pharmaceutically effective amount of an short-acting calcium channel blocking compound to treat ischemic heart conditions, cardiac arrhythmias, hypertensive crisis in an emergency room setting, hypertension before, during, or after surgery, no-reflow phenomenon following reperfusion, and diseases associated with decreased skeletal muscle blood flow. The invention also relates to pharmaceutical compositions formulated for use in such methods and to kits for such methods.Type: ApplicationFiled: June 16, 2014Publication date: October 2, 2014Inventors: Martin P. MAGUIRE, Elise Rioux, Harry J. Leighton
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Patent number: 8846732Abstract: Biogenic sulfide production is synergistically inhibited by treating sulfate-reducing bacteria (SRB) with a biocide and a metabolic inhibitor. The biocide directly kills a first portion of the SRB. The metabolic inhibitor inhibits sulfate-reducing growth of a second portion of the SRB without directly killing the second portion of the SRB. The treatment of SRB with both a biocide and a metabolic inhibitor provides effective biogenic sulfide inhibition at significantly lower concentrations than would be required if the biocide or metabolic inhibitor was used alone.Type: GrantFiled: October 6, 2010Date of Patent: September 30, 2014Assignees: ConocoPhillips Company, University Technologies International, Inc.Inventors: Gary E. Jenneman, Anne Greene, Gerrit Voordouw