Phosphorus Containing (e.g., Vitamin B12, Etc.) Patents (Class 514/52)
  • Patent number: 11384113
    Abstract: The present invention concerns cobalamin derivatives of formula (I) wherein X is a ligand having a formula selected from among: —(CH2)1-5—S—(CH2)0-3—CH3, —S—(CH2)1-5—NH2 and further wherein R1 is H, methyl or ethyl, R2 is and R3 is —H or and its use in diseases caused by lack of vitamin B12 support.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: July 12, 2022
    Assignee: Albert-Ludwigs-Universitaet-Freiburg
    Inventor: Luciana Hannibal
  • Patent number: 11369626
    Abstract: A method of treating a central nervous system disease, the method including administering an agent including a therapeutically effective amount of vitamin B12 to a patient with a central nervous system disease to treat the central nervous system disease. This disclosure also relates to a method of promoting M2 macrophage/microglia induction, inhibiting M1 macrophage/microglia induction, and/or reducing the ratio of M1 macrophage/microglia to M2 macrophage/microglia in a patient in need thereof, the method including administering an agent including a therapeutically effective amount of vitamin B12 to the patient to promote M2 macrophage/microglia induction, inhibit M1 macrophage/microglia induction, and/or reduce the ratio of M1 macrophage/microglia to M2 macrophage/microglia. This disclosure also relates to a pharmaceutical product including vitamin B12.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: June 28, 2022
    Assignees: OSAKA UNIVERSITY, NIPPON ZOKI PHARMACEUTICAL CO., LTD.
    Inventors: Hiroyuki Tanaka, Hideki Yoshikawa, Hideki Mochizuki, Tsuyoshi Murase, Tsutomu Sasaki, Kousuke Baba, Toru Iwahashi, Mitsuru Naiki
  • Patent number: 11357251
    Abstract: A micronutrient dosage unit which comprises two or more micronutrients selected from vitamin A, vitamin B2, vitamin B6, vitamin B9, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K, calcium, magnesium, zinc, boron and chromium in one or more specified ratios.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: June 14, 2022
    Inventor: Ralph Brown
  • Patent number: 11318136
    Abstract: Compositions for inhibiting the aggregation of a granin from a non-toxic low molecular weight form to a toxic high molecular weight aggregated form and/or dissociating a high molecular weight aggregated form to a low molecular weight form are provided. Such a composition typically includes one or more active compounds or agents, which may also be referred to herein as disaggregation compounds. Using the compounds and compositions described herein, methods of i) modulating, inhibiting or preventing the interaction of granins with metal ions, ii) modulating, inhibiting, preventing the aggregation of granins or dissociating aggregated granins, iii) reducing or inhibiting cell toxicity, iv) treating or preventing dementia or Alzheimer's disease, and v) preventing or treating Parkinson's and/or Huntington's diseases are also provided.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: May 3, 2022
    Inventor: Seung Hyun Yoo
  • Patent number: 11318144
    Abstract: Pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt of azelastine, and methylcobalamin are disclosed. Methods of using the pharmaceutical compositions for treating patients with Alzheimer's disease or Parkinson's disease are also disclosed.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: May 3, 2022
    Assignee: LA PharmaTech Inc.
    Inventors: Jianmin Wang, Geping Cui
  • Patent number: 11219590
    Abstract: PROBLEM: To provide an anti-aging agent and a method for the anti-aging that are safe in long-term intake and ensures effective suppression of the progress of the aging. SOLUTION: Nicotinamide mononucleotide is contained as an active ingredient.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: January 11, 2022
    Inventors: Megumi Tanaka, Tsunemaru Tanaka
  • Patent number: 11179381
    Abstract: The present invention relates to a method for administering water soluble physiologically active substances, said method comprising intranasally administering to a subject an aqueous composition comprising 0.001-25 wt. % of one or more fully dissolved physiologically active substances, the physiologically active substances having a water solubility in demineralized water of at least 15 mg/mL at 20° C. of, 0.01-10 wt. % nicotinamide, and at least 60 wt. % water. The invention also relates to a kit comprising said composition and to the use of nicotinamide as an enhancer of intranasal absorption of a physiologically active substance from an aqueous solution, wherein the aqueous solution further comprises 0.01-10 wt. % nicotinamide.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: November 23, 2021
    Assignee: DUTCH RENEWABLE ENERGY B.V.
    Inventors: Hubert Clemens Pellikaan, Rolf Lourens Visser
  • Patent number: 11154520
    Abstract: The present invention relates to methods and sets of drugs for the effective treatment of metastatic cancer and the administration of a set of drugs that overcome mechanisms of resistance to DNA-damaging agents, thereby sensitizing cancer cells to said DNA-damaging agents. The methods involve the administration of a set of drugs comprising melphalan, BCNU, hydroxocobalamin, and ascorbic acid. In a preferred embodiment, ethanol is also added to the set of drugs and bone marrow toxicity is reversed with an infusion of bone marrow stem cells. The methods also involve the depletion of GSH in tumors and the selective delivery of drugs to solid tumors. The methods also involve preventing the loss of catalase function and preventing oxidant-induced hemolysis and/or methemoglobin formation in subjects treated with oxidant drugs or agents that generate hydrogen peroxide, wherein said methods comprise the systemic administration of ethanol.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: October 26, 2021
    Assignee: General Oncology, Inc.
    Inventor: Arnold Glazier
  • Patent number: 11083738
    Abstract: Provided herein are dietary supplement compositions comprising a plurality of beadlets and an oil. Provided herein are also dietary supplement compositions comprising a plurality of mini-tabs and oil. The beadlets or mini-tabs comprise at least one nutrient that is miscible in aqueous solution, and the oil comprises at least one fat-soluble nutrient. The composition may be contained within one or more capsules, and be packaged with a scented insert.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: August 10, 2021
    Assignee: Natals, Inc.
    Inventors: Luke Bucci, Katerina Schneider
  • Patent number: 10973819
    Abstract: Embodiments concern methods and small molecule compositions for selectively inhibiting RAD51-mediated D-loop formation while preserving RAD51's ability to form nucleoprotein filaments. The selective RAD51 D-loop formation activity inhibitors DNA repair while minimizing replication-associated toxicity in normal tissue.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: April 13, 2021
    Assignee: The University of Chicago
    Inventors: Philip Connell, Wei Lv, Brian Budke, Alan Kozikowski
  • Patent number: 10973919
    Abstract: The invention relates to a vitamin preparation, especially for application to the skin, containing a physiologically effective amount of vitamin B12 or another precursor of coenzyme B12, a polysorbate as well as customary carrier substances for the formation of a gel matrix.
    Type: Grant
    Filed: July 23, 2013
    Date of Patent: April 13, 2021
    Assignee: Hilaltrade AG
    Inventor: Sven Reichwagen
  • Patent number: 10946041
    Abstract: Methods, compounds, and solutions for neurotransmitter restoration in a mammalian brain. The compound comprises calcium carbonate, pyridoxine hydrochloric acid, magnesium citrate, zinc amino acid chelate, chromium amino acid chelate, and a mixture comprising L-Tryptophan, L-Glutamine, L-Tyrosine, DL-Phenylalanine, and rhodiola. A visual indicator may be included to provide a easily discernable indication of the efficacy of a mixed solution.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: March 16, 2021
    Inventor: Patrece Frisbee
  • Patent number: 10918664
    Abstract: Risk of visual impairment including Age-Related Macular Degeneration (AMD) and cataracts increase with age. This increased risk can be caused by changes in the structure and function of the eye or changes in structures of the central nervous system that support visual perception. The present invention comprises fruit flavored, chewable formulations of supplements for reducing the risk of AMD. Chewable dosage forms of the invention are preferred over other formulations and may increase compliance in an aging population, who are more likely to require an eye health supplement and have an increased risk of experiencing dysphagia.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: February 16, 2021
    Inventors: Marc Bellemore, Ashley V Kasurak, Paul Charlton, Megan Thomas, John Doherty, Sorin Popa
  • Patent number: 10899789
    Abstract: The invention discussed in this application relates to vitamin B12-based compounds that are useful as quantitative standards, particularly for the assessment of vitamin B12 deficiency.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: January 26, 2021
    Assignee: Charles Sturt University
    Inventor: Peter Anderson
  • Patent number: 10765717
    Abstract: The present invention relates to a detoxifying composition containing a new green extract, which is a medicinal herb, as an active ingredient. Thus, toxicities in the human body can be efficiently removed without side effects by activating an enzyme necessary for detoxification.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: September 8, 2020
    Assignee: FAMENITY CO., LTD.
    Inventors: Yoo Hun Noh, Young Ja Kim, Jeong Min Lee
  • Patent number: 10709718
    Abstract: This invention pertains to the use of fused bicycle heterocyclic adducts of thiohydroxy pyridines or pyrimidines as diacylglycerol O-acyltransferase 1 (DGAT-1) inhibitors to treat hyperlipidiemias and various diseases and disorders associated therewith. Other conditions also be ameliorated or avoided, such as high postprandial triglycerides or diet-related hypertriglyceridemia, cardiovascular risk associated with excessive triglycerides, and insulin resistance/glucose intolerance in overweight patients, those with diabetes or other glucose metabolic disorders such as Syndrome X and/or polycystic ovary disease.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: July 14, 2020
    Assignee: Metabasis Therapeutics, Inc.
    Inventors: K. Raja Reddy, Jeff Stebbins, Serge H. Boyer, Mark D. Erion, Scott J. Hecker, Nicholas Brian Raffaele, Brett C. Bookser, Venkat Reddy Mali
  • Patent number: 10682325
    Abstract: This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: June 16, 2020
    Assignee: AXCELLA HEALTH INC.
    Inventors: William Comb, Sean Carroll, Raffi Afeyan, Michael Hamill
  • Patent number: 10294262
    Abstract: The invention provides compounds of formula I, wherein R1, R2 and R3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: May 21, 2019
    Assignee: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Aurelie Bourderioux, Michal Hocek, Petr Naus
  • Patent number: 10278987
    Abstract: The present invention relates to methods for treating optic disorders or for reducing or alleviating the signs, symptoms, or pathological conditions related to such optic disorders. In particular, methods are provided for treating optic disorders, or reducing the symptoms thereof, the methods involving the administration of one or more downstream folate compounds and/or methyl-B12. In one particular embodiment, the method comprises administration of L-methylfolate. In other embodiments, the method involves administering both L-methylfolate and methyl-B12. In still further embodiments, the method further involves reducing dietary intake of folic acid. In certain embodiments, the method further involves identifying a subject organism with a malfunction in one or more of the folate or B4 cycles. In certain embodiments, such a malfunction is one or more of the C677T and A1298C mutations.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: May 7, 2019
    Inventor: Brian W. Buell
  • Patent number: 10166252
    Abstract: The invention pertains to the use of a preparation for the manufacture of a composition for preventing or treating impaired plasma levels of one or more polar lipids such as phosphatidylcholines [PC] selected from the group consisting of phosphatidylcholine diacyl C36:6 [PC aa C36:6], phosphatidylcholine diacyl C38:0 [PC aa C38:0], phosphatidylcholine diacyl C38:6 [PC aa C38:6], phosphatidylcholine diacyl C40:6 [PC aa C40:6] and phosphatidylcholine acyl-alkyl C40:6 [PC ae C40:6] in a preclinical AD or MCI subject or a subject with a high likelihood of developing AD or MCI, and wherein said subject is administered with a composition comprising at least one, preferably at least two, most preferably all B vitamins selected from the group consisting of vitamin B6, vitamin B12 and vitamin B9.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: January 1, 2019
    Assignee: N.V. NUTRICIA
    Inventor: Nick Van Wijk
  • Patent number: 9896517
    Abstract: Provided are a low-molecular-weight fucosylated glycosaminoglycan derivative (derivative of Low molecular weight Fucosylated Glycosaminoglycan, dLFG) having anticoagulant activity, a preparation method thereof, a pharmaceutical composition comprising dLFG or a pharmaceutically acceptable salt thereof, and the use of dLFG and pharmaceutical composition thereof in preparing medicine for treating thrombotic diseases.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: February 20, 2018
    Assignee: Jiuzhitang Co., Ltd.
    Inventors: Jinhua Zhao, Jikai Liu, Mingyi Wu, Na Gao, Feng Lu, Zi Li
  • Patent number: 9877939
    Abstract: Described herein is a method for increasing levels of S-adenosylmethionine within the human body without administering S-adenosylmethionine directly. The method of the invention may be achieved by administering one or more of L-methionine, methylcobalamin, 5-Methyl tetrahydrofolate, betaine, and malic acid, together. with at least one compound selected from the group consisting of folic acid, vitamin B12, magnesium, calcium, and other cofactors.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: January 30, 2018
    Assignee: Fast Balance, LLC
    Inventor: Brian D. Halevie-Goldman
  • Patent number: 9855292
    Abstract: The current invention discloses novel approaches to help individuals defend against headaches and body pains with orally-delivered cyanocobalamin, methylcobalamin, adenosylcobalamin, and combinations thereof. Original clinical research conducted by the inventor on almost 2,000 humans yielded surprising and unexpected results showing differences in the frequency and severity of pains in the head and the body favoring cyanocobalamin patients over placebo. In one FDA-approved Phase III study on 1,551 patients, 4.4 percent of headaches and body pains were rated as “Severe” in the cyanocobalamin, group versus 11.5 percent in the placebo group. Once inside the body, cyanocobalamin is converted to methylcobalamin and adenosylcobalamin, but not to hydroxocobalamin.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: January 2, 2018
    Inventor: Ernest Timothy Armstrong
  • Patent number: 9814702
    Abstract: The present application relates to topical formulations comprising Compound-I or its free base, and a second active agent selected from nicotinic acid, nicotinamide, and vitamin K, and a combination thereof, for treating ocular neovascularization. The present application also relates to pharmaceutical compositions comprising particles of Compound-I or its free base, and suspension formulations comprising the particle compositions of Compound-I or its free base.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: November 14, 2017
    Assignee: PanOptica, Inc.
    Inventors: David P. Bingaman, Paul G. Chaney, Martin B. Wax
  • Patent number: 9801821
    Abstract: The present invention relates to stable solid formulations of vitamin D3 and to processes for preparation of the same. The present invention provides stabilized compositions comprising vitamin D3 at least one lipophilic dispersant, one or more antioxidants, at least one adsorbent and one or more pharmaceutically acceptable excipients and further coated with a barrier coating.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: October 31, 2017
    Assignee: PSM Healthcare Limited
    Inventors: Anilkumar S. Gandhi, Pratibha S. Pilgaonkar, Maharukh T. Rustomjee
  • Patent number: 9624257
    Abstract: The invention provides compounds of formula I: wherein R1, R2 and R3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: April 18, 2017
    Assignee: Institute of Organic Chemistry and Biochemistry of the ASCR, V.V.I.
    Inventors: Aurelie Bourderioux, Michal Hocek, Petr Naus
  • Patent number: 9421206
    Abstract: Methods of treating hematological disorders including macrocytosis, and for decreasing hematological markers such as mean corpuscular volume, homocysteine and methylmalonic acid are described, based on the administration of levomefolate, optionally in combination with vitamin B12, iron or an anti-folate drug.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: August 23, 2016
    Inventor: Clark Gerald Sullivan
  • Patent number: 9248100
    Abstract: Sustained-released beads providing active ingredients over an extended period of time to an individual orally ingesting the sustained release beads. The sustained-release beads can be part of a suspension wherein the sustained-release beads are suspended and evenly dispersed in the suspension. Binding agents are used to form the structural framework of the sustained released beads and retain the active ingredients without chemical or electrical bonding. The components of the dispersion medium are GRAS designated, making the suspension suitable for use as a food product.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: February 2, 2016
    Assignee: Nano Pharmaceutical Laboratories LLC
    Inventor: Robert Niichel
  • Patent number: 9186374
    Abstract: The present invention relates generally to vitamin B12 nasal spray compositions and methods of using the same in the treatment of vitamin B12 deficiency and various disorders that are related to such deficiency. In particular embodiments, the present invention is directed to treatment methods comprising intranasal administration of a cobalamin composition according to a particular dosing and frequency schedule and to a preservative-free nasal spray composition comprising a cobalamin compound useful in the practice of such treatment methods.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: November 17, 2015
    Assignee: Par Pharmaceutical, Inc.
    Inventors: Theodore H. Feller, Angela Sutterer, Patrick J. Arnall
  • Patent number: 9040082
    Abstract: Pharmaceutical compositions and methods for the treatment of chronic fatigue in human patients comprising a central nervous system (CNS) stimulant in a daily low-dosage amount in combination with therapeutically effective daily amounts of micronutrients, comprising acetyl L-carnitine, L-tyrosine, N-acetyl cysteine, and alpha-lipoic acid. The CNS and micronutrient components may be in an oral dosage composition containing a low dosage amount of CNS stimulant such as about 2.5 mg methylphenidate HCl together with about 60-250 mg acetyl L-carnitine, 50-200 mg L-tyrosine, 60-250 mg N-acetyl cysteine, and 25-100 mg alpha-lipoic acid.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: May 26, 2015
    Inventor: Jon D. Kaiser
  • Publication number: 20150136638
    Abstract: The present invention relates to a method for preparing a syrupy product comprising vitamins, said method comprising the following steps: a) inerting all the apparatuses implemented in the method b) inserting sugar syrup into said apparatuses and adding vitamins under inert atmosphere; c) adding dehydrated and deoxygenated glucose under inert atmosphere; d) deoxygenating the syrupy product formed in this way; e) packaging the syrupy product under inert atmosphere.
    Type: Application
    Filed: January 29, 2013
    Publication date: May 21, 2015
    Applicant: LaboratoiresUrgo
    Inventors: Franck Eymard, Pierre Gabiot, Romain Brenon, Michel Lamoise
  • Publication number: 20150141366
    Abstract: The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat esophogeal adenocarcinoma by one or a combination of (i) administering triciribine only to patients which according to a diagnostic test described below, exhibit enhanced sensitivity to the drug; (ii) use of a described dosage level that minimizes the toxicity of the drug but yet still exhibits efficacy; or (iii) use of a described dosage regimen that minimizes the toxicity of the drug.
    Type: Application
    Filed: June 3, 2013
    Publication date: May 21, 2015
    Inventor: Jin Q. CHENG
  • Publication number: 20150132410
    Abstract: The invention provides compositions for the prevention and treatment of the symptoms of alcoholic beverage-induced hangover syndrome, related kits and methods of using the compositions and kits.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 14, 2015
    Inventor: Michael M. Jacobs
  • Publication number: 20150133397
    Abstract: A method of treatment for reducing elevated fasting insulin levels of subjects with a MTHFR gene deficiency is provided. The method includes first determining whether a subject has an MTHFR gene deficiency. Once a subject has been found to have the MTHFR gene deficiency, the fasting insulin levels of the subject are determined. If the subject has a high fasting insulin level, the subject is administered an active folate.
    Type: Application
    Filed: August 8, 2014
    Publication date: May 14, 2015
    Inventors: Jeffrey Lynn Barringer, Stephen Albert Smith, Jerry Golden
  • Publication number: 20150119321
    Abstract: A unique combination of weight loss modalities that produce 20-40 pounds of weigh loss in a six week treatment period. Treatment includes a meal plan chosen to provide adequate protein and nutrition during dieting and to assist metabolism of toxins created from the release of stored fat, high amounts of fiber to assist in collecting toxins and fat in the elimination system and to encourage peristaltic action in the bowel, a bowel toner to further increase peristaltic action in the bowel, stimulating liver functions of fat and toxins. The weight loss portion of the treatment is limited to six week segments, and added to the plurality of modalities comprising the invention, to further support the body during weight loss. By supporting the body during weight loss, his invention(s) avoids the “plateau” routinely experienced by existing weight loss systems, when the metabolism slows to avoid further damage from ultra-low calories, medications, bariatric surgeries, and other stressful programs.
    Type: Application
    Filed: April 5, 2013
    Publication date: April 30, 2015
    Inventor: Linda Duerler FINCH
  • Publication number: 20150105343
    Abstract: In various embodiments, a cell culture medium, or a nucleoside cocktail transmission (NCT) medium for the culture of stem cells with improved genetic stability, cellular function and regeneration ability is provided. Illustrative culture media comprise a basal culture medium for stem cells, where the culture medium is supplemented with one or more nucleoside triphosphates (e.g., dNTPs and/or NPs) or one or more precursors thereof. Illustrative NCT media comprise a delivery vehicle (e g. skin creams or other vehicle) containing one or more nucleoside triphosphates (e.g., dNTPs and/or NPs) or one or more precursors thereof. The NCT medium provides, inter alia, direct delivery of nucleoside cocktails into human tissues (such as skin) for regenerative, cosmetic and/or therapeutic purposes.
    Type: Application
    Filed: October 16, 2014
    Publication date: April 16, 2015
    Inventors: James A. Byrne, Caius Radu, Patrick Lee
  • Publication number: 20150104499
    Abstract: The present invention is directed to compositions and devices for transdermally administering vitamin B12 to a subject. In one aspect, a vitamin B12 containing composition suitable for transdermal administration is provided in the form of a shelf stable transdermal delivery patch. Such patches contain vitamin B12 combined with selected penetration enhancers and vitamin B12 stabilizers.
    Type: Application
    Filed: December 16, 2014
    Publication date: April 16, 2015
    Applicant: Vita Science LLC
    Inventor: Jon Zeltman
  • Publication number: 20150093454
    Abstract: The present invention relates to a composition comprising alfa-lipoic acid, or a salt or complex thereof, and honokiol, wherein the weight quantity of said honokiol is between 1% and 30% with respect to the total weight of honokiol and alfa-lipoic acid.
    Type: Application
    Filed: April 19, 2013
    Publication date: April 2, 2015
    Inventors: Carlo Terruzzi, Fabio Terruzzi
  • Publication number: 20150086676
    Abstract: The present invention relates to a process for production of a sterile aqueous formulation comprising water-soluble vitamins. Such a formulation is useful as a premix for the production of food, feed and personal care products. Furthermore the invention is also related to such sterile aqueous formulations as well as the use of them in the production of food, feed or personal care products, which are pasteurized.
    Type: Application
    Filed: May 2, 2013
    Publication date: March 26, 2015
    Inventor: Hendrik Ruijter
  • Publication number: 20150079149
    Abstract: A strip, which is both edible and dissolvable, is provided comprising a film and a dosage of at least 2% of the reference daily intake (RDI) of at least one dietary supplement for malnutrition or to prevent/treat alcohol induced hangovers. A method for treating malnutrition and/or preventing and treating alcohol-induced hangovers using a dissolvable orally administered strip.
    Type: Application
    Filed: November 19, 2014
    Publication date: March 19, 2015
    Inventor: Alessandra Grassi
  • Publication number: 20150065449
    Abstract: A method of treating amyloid-beta peptide aggregation in a subject includes contacting at least one amyloid-beta peptide oligomer formed from a plurality of amyloid-beta peptide monomers with a composition containing melatonin, resveratrol, EGCG, and an effective amount of vitamin B12. The effective amount of vitamin B12 being sufficient to stimulate dissociation of the amyloid-beta peptide monomers from the at least one amyloid-beta peptide oligomer. The composition may be used to treat amyloidosis, including Alzheimer's disease.
    Type: Application
    Filed: November 12, 2014
    Publication date: March 5, 2015
    Inventor: Ewa Anna Bienkiewicz
  • Publication number: 20150065448
    Abstract: Embodiments of the invention include methods of using vitamin B12 to influence amyloid-beta peptide aggregation. A preferred method comprises contacting at least one amyloid-beta peptide oligomer formed from a plurality of amyloid-beta peptide monomers with an effective amount of vitamin B12, the effective amount being sufficient to stimulate dissociation of the amyloid-beta peptide monomers from the amyloid-beta peptide oligomer or fibril. Also provided are methods of treating Alzheimer's disease and diagnostic tests for detecting the presence of amyloid-beta peptides.
    Type: Application
    Filed: August 13, 2012
    Publication date: March 5, 2015
    Applicant: THE FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION INC.
    Inventor: Ewa Bienkiewicz
  • Publication number: 20150065561
    Abstract: The present invention is based, in part, on our studies of molecular pathways that include the deubiquitinase CYLD. Accordingly, the present invention features, inter alia, nucleic acid constructs that express CYLD or a biologically active variant thereof (e.g., a variant including the catalytic domain), nucleic acids that inhibit the expression of a negative regulator of CYLD (e.g., PDE4B or LNK2), nucleic acids that modulate the expression of downstream CYLD targets (e.g., Akt, by inhibiting or promoting the expression of the downstream target), compositions including one or more of these types of constructs (e.g., pharmaceutical compositions), kits including one or more of the compositions described herein and instructions for use, screening methods to identify therapeutic agents {e.g., anti-inflammatory agents) that upregulate CYLD, downregulate a negative regulatory of CYLD, or modulate (e.g., inhibit) a downstream CYLD target (e.g.
    Type: Application
    Filed: April 9, 2013
    Publication date: March 5, 2015
    Applicant: Georgia State University Research Foundation, Inc.
    Inventor: Jian-Dong Li
  • Patent number: 8952040
    Abstract: Pharmaceutical composition for treating coagulation disorder hemorrhage. The pharmaceutical composition comprises (per unit): L-ornithine 0.5˜8 g, aspartic acid 1˜5 g, arginine 3˜10 g and vitamin B6 3˜10 g. A method of administrating the pharmaceutical composition to treat hemorrhage patients caused by coagulation dysfunction, especially critically ill patients.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: February 10, 2015
    Inventors: Maoxing Yue, Honggui Wan, Tongge Huang
  • Publication number: 20150038453
    Abstract: It has been found that high amounts of aspartate equivalents in combination with vitamin B12 and/or biotin, especially in relative absence of glutamate equivalents, improve the metabolism of ketobodies and/or lactate in a mammal's body, especially in diseased or traumatic conditions. As a result, levels of ketobodies and lactate can be decreased and unphysicologically high acidity normalised. Thus, it is an object of the invention to provide an enteral nutritional or a pharmaceutical composition for the treatment and/or prevention of disturbed ketone and lactate metabolism, i.e. elevated concentrations of ketone bodies, lactate and/or other organic acids and/or insufficient pH homeostasis, especially elevated concentrations of ketone bodies and/or lactate, in a mammal's blood, wherein the composition comprises high amounts of aspartate equivalents in combination with vitamin B12 and/or biotin, preferably in relative absence of glutamate equivalents.
    Type: Application
    Filed: October 16, 2014
    Publication date: February 5, 2015
    Applicant: N.V. Nutricia
    Inventor: Robert Johan Joseph HAGEMAN
  • Publication number: 20150037438
    Abstract: An oral pharmaceutical composition in unit dose form, each unit dose comprising a lipophilic drug substance within a unitary carrier body, said body comprising a soft, chewable, gelled oil-in-water emulsion.
    Type: Application
    Filed: October 15, 2014
    Publication date: February 5, 2015
    Inventors: Tore SETERNES, Kurt Ingar Draget, Ingvild Johanne Haug
  • Publication number: 20150037414
    Abstract: A controlled Release Pharmaceutical composition comprising an effective amount of Pravastatin and Fenofibrate, characterised in that the difference, in absolute value, between the times of maximal concentration (Tmax) of Pravastatin and Fenofibric acid is not less than 1.5 hours upon administration with food to humans.
    Type: Application
    Filed: July 7, 2010
    Publication date: February 5, 2015
    Applicant: GALEPHAR M/F
    Inventors: Arthur M. Deboeck, Philippe Baudier, Francis Vanderbist, Antonio Sereno
  • Publication number: 20150038452
    Abstract: The present invention relates to methods for treating optic disorders or for reducing or alleviating the signs, symptoms, or pathological conditions related to such optic disorders. In particular, methods are provided for treating optic disorders, or reducing the symptoms thereof, the methods involving the administration of one or more downstream folate compounds and/or methyl-B12. In one particular embodiment, the method comprises administration of L-methylfolate. In other embodiments, the method involves administering both L-methylfolate and methyl-B12. In still further embodiments, the method further involves reducing dietary intake of folic acid. In certain embodiments, the method further involves identifying a subject organism with a malfunction in one or more of the folate or B4 cycles. In certain embodiments, such a malfunction is one or more of the C677T and A1298C mutations.
    Type: Application
    Filed: August 14, 2014
    Publication date: February 5, 2015
    Inventor: Brian W. Buell
  • Publication number: 20150030585
    Abstract: This application encompasses combination therapies including triciribine and related compounds and one or more platinum compounds and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.
    Type: Application
    Filed: November 27, 2013
    Publication date: January 29, 2015
    Applicant: University of South Florida
    Inventors: Jin Q. CHENG, Said M. Sebti
  • Publication number: 20150030579
    Abstract: Hydroxytyrosol or olive juice containing hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1, B2, B3, B5, B6, and/or B12) and ginseng (preferably: root) extract. can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.
    Type: Application
    Filed: August 1, 2014
    Publication date: January 29, 2015
    Applicant: DSM IP ASSETS B.V.
    Inventors: Ann FOWLER, Angelika FRIEDEL, Darko KNUTTI, Karin KURATLI, Daniel RAEDERSTORFF, Ying WANG-SCHMIDT, Karin WERTZ