Phosphorus Containing (e.g., Vitamin B12, Etc.) Patents (Class 514/52)
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Publication number: 20130101636Abstract: There is provided a dietary supplement product comprising a sealed package containing a single dose of a dietary supplement, the dietary supplement including one or more active agents such as vitamins and mineral dispersed with a carrier so that it is in the form of a free-flowing, dry particulate which pours readily and dissolves rapidly on the tongue.Type: ApplicationFiled: October 12, 2012Publication date: April 25, 2013Inventor: Kevin W. Lang
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Publication number: 20130095190Abstract: Disclosed are health drink compositions. One example composition provides a health drink that includes 10-15 mg/10 ml of calcium lactate gluconate, 400-600 mcg/10 ml of folic acid, 40-50 mg/10 ml of magnesium gluconate, a combination of complex B vitamins, purified water, and natural fruit flavoring. Other example health drinks are also included in the present application.Type: ApplicationFiled: October 12, 2012Publication date: April 18, 2013Inventor: Garabet Varkes Kassabian
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Publication number: 20130090304Abstract: This application relates to combination therapies including triciribine and related compounds and taxanes and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.Type: ApplicationFiled: April 20, 2012Publication date: April 11, 2013Inventors: Jin Q. Cheng, Said M. Sebti
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Publication number: 20130090305Abstract: The current invention presents a dietary supplement obtained from a mixture of melatonin, vitamins and aminoacids and administered for healing or regressing the symptoms of gastroesophageal reflux disease, such as heartburn, regurgitation, dysphagia, coughing, hoarseness, chest pain and odynophagia, gastritis and several types of ulcerations.Type: ApplicationFiled: December 3, 2012Publication date: April 11, 2013Inventor: Ricardo de Souza Periera
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Publication number: 20130089623Abstract: The present invention provides methods and compositions for treating thyroid-related medical conditions. Many thyroid-related medical conditions exist that go undiagnosed and untreated. These conditions may be prevented and treated with reduced folates and vitamin B12. Administration of reduced folates and vitamin B12 will prevent or treat cerebrospinal folate deficiency, which is linked to thyroid-related medical conditions. Administration of reduced folates and vitamin B12 will also prevent or treat conditions associated with masked megaloblastic anemia and hypothyroidism, and other conditions brought upon through improper thyroid function. Additionally, it is commonplace to treat many thyroid conditions with anti-thyroid drugs or thyroid stimulating drugs. This practice alone is also responsible for causing, or not beneficially addressing, adverse conditions that can be prevented or treated through the methods and compositions discussed herein.Type: ApplicationFiled: November 28, 2012Publication date: April 11, 2013Inventor: Linzy O. Scott, III
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COMPOSITIONS FOR EXTERNAL APPLICATION, CONTAINING ADENOSYLCOBALAMIN FOR IMPROVEMENT OF SKIN DISEASES
Publication number: 20130084329Abstract: The present invention relates to a composition for external application for improving a skin disease (e.g. psoriasis). The composition contains adenosylcobalamin (coenzyme B12), optionally in admixture with other cobalamins. The composition can be present in the form of liposomal preparations, which are made of a phospholipid and cholesterol.Type: ApplicationFiled: November 16, 2012Publication date: April 4, 2013Applicants: HANALL BIOPHARMA CO., LTD., KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGYInventors: Korea Research Institute of Chemical Technology, HANALL BIOPHARMA CO., LTD. -
Publication number: 20130084272Abstract: The present invention relates to compositions, kits and methods for the administration of compositions and kits for supplementation with twelve carbon chain fatty acids or twelve carbon chain acylglycerols; and specifically for the supplementation with twelve carbon chain fatty acids such as lauric acid and twelve carbon chain acylglycerols such as monolaurin; and specifically for the co-supplementation with other vitamins, minerals and nutrients.Type: ApplicationFiled: September 29, 2011Publication date: April 4, 2013Inventors: Philippe PERRIN, Guillaume HERRY, Cecile BOYER-JOUBERT
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Publication number: 20130059813Abstract: The present disclosure provides a method for treating dermatological conditions, such as psoriasis, dermatitis, and dandruff. Said conditions are treated by administering to a person a vitamin supplement composition comprising folic acid, vitamin B12 and/or vitamin B6.Type: ApplicationFiled: November 1, 2012Publication date: March 7, 2013Inventor: Dav Devlin
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Publication number: 20130052234Abstract: An edible oral strip composition includes a therapeutically effective amount of active agent(s) to provide at least one effect selected from a stimulating effect, an increased physical endurance, alleviate temporary fatigue, improve nervous system functions, and combinations of any of the foregoing. In additional embodiments, the edible strip composition includes a therapeutically effective amount of active agent(s) to provide sleep aid.Type: ApplicationFiled: August 3, 2012Publication date: February 28, 2013Applicant: Purebrands LLCInventors: Michael Goldberg, Ehud Arbit
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Publication number: 20130045183Abstract: The present disclosure relates to non-acidic extracts or fractions selected from a Boswellia low polar gum resin extract fraction (BLPRE), a Boswellia volatile oil fraction (BVOIL), and a Boswellia oil fraction (BOIL) and their compositions. BLPRE, BOIL, and BVOIL are each derived from the gum resin of a Boswellia species. These compositions are useful for improving mental condition, enhancing brain functions such as cognition, memory, learning, communication and brain health, for treating impaired memory, and for preventing, control or treating memory and cognition related disorders/diseases. Additionally, BOIL, BVOIL, and mixtures of BOIL and BVOIL are useful for enhancing the bioavailability of a biological agent.Type: ApplicationFiled: September 14, 2012Publication date: February 21, 2013Applicant: LAILA NUTRACEUTICALSInventors: Ganga Raju GOKARAJU, Rama Raju GOKARAJU, Venkata Kanaka Ranga Raju GOKARAJU, Trimurtulu GOLAKOTI, Kiran BHUPATHIRAJU, Venkata Krishna Raju ALLURI
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Publication number: 20130040910Abstract: A novel method and composition for treating vitamin B12 deficiency mammals that fail to respond to oral vitamin B12 therapy.Type: ApplicationFiled: September 14, 2012Publication date: February 14, 2013Applicant: Emisphere Technologies, Inc.Inventors: Cristina CASTELLI, Laura KRAGIE
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Patent number: 8372825Abstract: Skin compositions comprising, hydrocortisone; allantoin; and a water-based vehicle that is essentially free of petroleum jelly, mineral oil and wax; and related method for protecting, healing and/or soothing the skin comprising: applying an effective amount of a cosmetic preparation selected from the group consisting of hand cream, foot cream, body cream, lip cream, lip gloss, lip stick, gel, balm and lotion to the skin surface; wherein said cosmetic preparation includes a skin composition made of hydrocortisone; allantoin; and a water-based vehicle that is essentially free of petroleum jelly, mineral oil and wax; and said effective amount is enough to protect, heal and/or soothe the skin surface.Type: GrantFiled: August 13, 2009Date of Patent: February 12, 2013Inventor: Norman Turkowitz
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Publication number: 20130029930Abstract: The invention provides a method of increasing a deacetylated activity of SIRT6 by contacting SIRT6 with an agent that binds SIRT6 and reduces the Km of SIRT6 for a substrate, thereby increasing the deacetylase activity of SIRT6. The invention also provides compounds of the formulas (II) and (III).Type: ApplicationFiled: December 14, 2010Publication date: January 31, 2013Applicant: CORNELL UNIVERSITYInventors: Anthony Sauve, Ping Xu
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Patent number: 8362078Abstract: The present invention relates to the use of polyunsaturated fatty acids and one or more components which have a beneficial effect on total methionine metabolism selected from the group consisting of vitamin B12 and precursors thereof, vitamin B6 and derivatives thereof, folic acid, zinc and magnesium, in the manufacture of a preparation for improving the action of receptors. This preparation is advantageously applied in patients suffering from Parkinson's disease, Huntington's chorea, epilepsy, schizophrenia, paranoia, depression, sleep disorders, impaired memory function, psychoses, dementia and ADHD.Type: GrantFiled: December 1, 2008Date of Patent: January 29, 2013Assignee: N.V. NutriciaInventors: Amanda Johanne Kiliaan, Robert Johan Joseph Hageman
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Patent number: 8361988Abstract: The present invention comprises compounds useful as antiviral or antitumor agents. The compounds comprise nucleotide analogues that comprise tetrahydrofuranyl or tetrahydrothienyl moeities with quaternary centers at the 3? position. The nucleotide analogues can be used to inhibit cancer or viruses. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting diseases or conditions associated with cancers and viruses. Thus, the present invention also comprising pharmaceutical formulations comprising the compounds and methods of using the compounds and formulations to inhibit viruses or tumors and treat, prevent, or inhibit the foregoing diseases.Type: GrantFiled: January 17, 2008Date of Patent: January 29, 2013Assignee: Institut de Recherches Cliniques de MontrealInventor: Yvan Guindon
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Publication number: 20130023491Abstract: In the invention provides for a method of stimulating or increasing ?-cell replication or growth, by contacting a ?-cell with an inhibitor of adenosine kinase (ADK), an inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) or an activator of AMP activated protein kinase (AMPK).Type: ApplicationFiled: December 17, 2010Publication date: January 24, 2013Applicants: President and Fellows of Harvard College, Joslin Diabetes Center, Inc., The Brigham and Women's Hospital, Inc.Inventors: Justin P. Annes, Douglas A. Melton, Lee L. Rubin, Gordon Weir
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Publication number: 20130018013Abstract: The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.Type: ApplicationFiled: September 7, 2012Publication date: January 17, 2013Applicant: BIOTA SCIENTIFIC MANAGEMENT PTY LTDInventors: Paula Francom, Barbara Frey, Silas Bond, Alistair George Draffan, Michael Harding, Richard Hufton, Saba Jahangiri, Michael John Lilly, Edward Tyndall, Jianmin Duan, Richard Bethell, George Kukolj
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Publication number: 20130012469Abstract: The invention pertains to a liquid composition for preventing and/or treating memory decline and/or cognitive dysfunction, Alzheimer's, Parkinson's and/or dementia, said composition comprising: (i) at least 50 mg nucleoside and/or nucleotide per 100 ml; (ii) between 0.2 and 10 grams protein per 100 ml; (iii) between 0.05 and 3 wt. % of thickener, based on total weight of the composition. The thickener is preferably selected from the group consisting of cellulose, xanthan gum, gellan gum, alginate, guar gum, locust bean gum, gum karaya, gum tragacanth, carrageenan, and mixtures thereof. The composition preferably has a loss factor tan ? between 0.1 and 100, as measured at any strain in the range of 1-100% at 0.1 Hz and 20° C. It is particularly found that a thickener selected from the group consisting of gellan gum, xanthan gum and cellulose greatly reduces sedimentation.Type: ApplicationFiled: September 14, 2012Publication date: January 10, 2013Inventors: Esther Jacqueline DE KORT, Robert Johan Joseph Hageman, Martine Groenendijk, Patrick Joseph Gerardus Hendrikus Kamphuis
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Publication number: 20130011460Abstract: The present invention discloses a drug-carrying contact lens and a method for fabricating the same. The drug-carrying contact lens comprises a contact lens containing at least one amphiphatic hybrid nanocarrier carrying drug molecules. According to the heat or light sensitivity of the drug molecule, the present invention respectively fabricates an encapsulation-type drug-carrying contact lens and a drug-soaking type drug-carrying contact lens. The present invention uses a highly-biocompatible amphiphatic hybrid nanocarriers having superior drug encapsulation capability to wrap the drug molecules. Thereby, the drug molecules are uniformly distributed in the contact lens and can be gradually and locally released to the eye of the user wearing the contact lens. Therefore, the present invention can prevent or cure ocular diseases with the loss and side effects of the drug being reduced.Type: ApplicationFiled: October 7, 2011Publication date: January 10, 2013Inventors: Dean-Mo Liu, Pei-Ling Liu
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Patent number: 8349826Abstract: The invention relates to compounds of Formula (I) wherein U, V, W, R1, R1b, A and G are as defined in the description, to pharmaceutically acceptable salts of such compounds and to the use of these compounds in the manufacture of a medicament for the prevention or treatment of a bacterial infection.Type: GrantFiled: February 20, 2009Date of Patent: January 8, 2013Assignee: Actelion Pharmaceuticals Ltd.Inventors: Christian Hubschwerlen, Georg Rueedi, John-Philippe Surivet, Cornelia Zumbrunn-Acklin
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Patent number: 8349812Abstract: Immunostimulatory oligoribonucleotides (ORN) featuring 5?-triphosphates and various 5?-triphosphate analogs are provided. Also provided are physiologically acceptable salts of the immunostimulatory ORN and pharmaceutical compositions containing the immunostimulatory ORN of the invention. ORN of the invention are useful as adjuvants and can be combined with an antigen to promote an antigen-specific immune response. ORN of the invention are also particularly useful for promoting a Th1-type immune response. Also provided are methods of use of the compounds and pharmaceutical compositions of the invention to enhance an immune response in a subject, as well to treat a number of conditions including cancer, infection, allergy, and asthma, and to vaccinate a subject against an antigen.Type: GrantFiled: October 30, 2008Date of Patent: January 8, 2013Assignee: AdiuTide Pharmaceuticals GmbHInventors: Harald Debelak, Eugen Uhlmann
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Publication number: 20130005679Abstract: Provided are multivitamin compositions comprising vitamin B1, vitamin B2, vitamin B5, vitamin B6, vitamin B12, folic acid, magnesium glycinate, and selenium. These compositions are effective and natural treatments for improving health in a mammal. In some embodiments, the multivitamin compositions are administered to a female mammal to normalize a menstrual cycle. In other embodiments, the multivitamin compositions are administered to treat a sleep disorder.Type: ApplicationFiled: January 3, 2012Publication date: January 3, 2013Inventor: Tasneem Bhatia
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Publication number: 20120329749Abstract: The present invention relates to methods of treating, preventing, and/or improving disorders and conditions related to certain metabolic abnormalities including methods of improving blood lipid profiles and muscle recovery and repair in athletes, methods of treating fibromyalgia, erectile dysfunction, diseases associated with certain HLA-DQ gene alleles and/or gluten intolerance, including Celiac Disease, headaches and migraines, as well as idiopathic neuropathy, inability to sleep, inability to concentrate, and/or neurological development issues in children, the methods involving the administration of one or more downstream folate compounds and optionally methyl-B12. In one particular embodiment, the method comprises administration of L-methylfolate. In certain embodiments, the method further involves identifying a subject organism with a malfunction in one or more of the folate or B4 cycles. In certain embodiments, such a malfunction is one or more of the C677T and A1298C genetic polymorphisms.Type: ApplicationFiled: June 20, 2012Publication date: December 27, 2012Inventors: Stephen Albert Lonnie Smith, Jeffrey Lynn Barringer, Craig Jay Brown, Gilberto Sanchez, Stephanie Michelle Ott, Brian Buell
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Publication number: 20120328695Abstract: Pharmaceutical compositions and methods for the treatment of chronic fatigue in human patients comprising a central nervous system (CNS) stimulant in a daily low-dosage amount in combination with therapeutically effective daily amounts of micronutrients, comprising acetyl L-carnitine, L-tyrosine, N-acetyl cysteine, and alpha-lipoic acid. The CNS and micronutrient components may be in an oral dosage composition containing a low dosage amount of CNS stimulant such as about 2.5 mg methylphenidate HCl together with about 60-250 mg acetyl L-carnitine, 50-200 mg L-tyrosine, 60-250 mg N-acetyl cysteine, and 25-100 mg alpha-lipoic acid.Type: ApplicationFiled: June 22, 2012Publication date: December 27, 2012Inventor: Jon D. Kaiser
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Publication number: 20120329748Abstract: The invention provides a method of increasing a deacetylase activity of SIRT5 by contacting SIRT5 with an agent that binds SIRT5 and reduces the Km of SIRT5 for a substrate, thereby increasing the deacetylase activity of SIRT5. The invention also provides a method for treating a urea cycle disorder in a mammal, as well as a method of assaying a sirtuin modulator.Type: ApplicationFiled: December 14, 2010Publication date: December 27, 2012Applicant: CORNELL UNIVERSITYInventors: Anthony Sauve, Yana Cen
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Publication number: 20120328712Abstract: The present invention relates to new rhenium compounds of formula (I) with medical utility, corresponding pharmaceutical compositions as well as medical uses thereof.Type: ApplicationFiled: March 4, 2011Publication date: December 27, 2012Applicant: UNIVERSITY OF ZURICHInventors: Fabio Zobi, Roger Alberto, Lukas Kromer
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Patent number: 8329227Abstract: The present invention provides formulas for producing compositions for the structural/functional nutritional support for those who struggle with poor focus, concentration and/or memory. In addition, the present invention provides compositions comprising nutritional/botanical factors helpful to those who subjectively experience transient mental fatigue or poor cognitive function. The compositions of this invention consist primarily of the following ingredients B-complex vitamins, antioxidants, minerals, phosphatidyl serine (PS), choline, dimenthyl-aminoethanol (DMAE), docosahexaenoic acid (DHA), L-pyroglutamic acid, as well as herbal extracts from Bacopa monniera, Vinca minor, and Huperzia serrata. The present invention also relates to the administration of these compounds to alleviate mental fatigue or poor cognitive function.Type: GrantFiled: December 7, 2004Date of Patent: December 11, 2012Assignee: Factor Nutrition Labs, LLCInventor: Kyl L. Smith
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Patent number: 8318196Abstract: The invention relates to aqueous formulations comprising alkoxylated castor oils with 15-25 ethyleneoxy units and a vitamin, preferably a fat-soluble vitamin, as well as to the use of such formulations in the process to administer the vitamin to an animal, or to make personal care formulations comprising the vitamin.Type: GrantFiled: June 25, 2007Date of Patent: November 27, 2012Assignee: Akzo Nobel N.V.Inventor: Inger Olausson
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Patent number: 8313784Abstract: A method of using guava extract is disclosed that includes administering guava extract to a mammal to inhibit, prevent or alleviate at least one of a headache, nausea, dry mouth, lack of appetite, shakiness, and fatigue. A composition is also disclosed that includes a pharmaceutically acceptable carrier and guava extract.Type: GrantFiled: January 21, 2011Date of Patent: November 20, 2012Assignee: Amerilab Technologies, Inc.Inventors: Fred Wehling, Mary Aldritt, GeMing Lui
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Publication number: 20120289476Abstract: Methods for treating methylmalonic acidemia in which at least one allele of a gene associated with MMA (e.g., the MUT, MMAA, or MMAB gene) contains a mutation (e.g., nonsense mutation) that results in a premature stop codon in RNA encoded by an allele of the gene associated with MMA involving the administration of a compound that promotes readthrough of RNA (e.g., messenger RNA) containing a premature stop codon encoded by an allele of the gene associated with MMA are described. The compound can be administered as a single-agent therapy or in combination with one or more additional therapies to a human in need of such treatment.Type: ApplicationFiled: December 13, 2010Publication date: November 15, 2012Inventor: Jay Allan Barth
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Publication number: 20120288529Abstract: The present invention relates to a pharmaceutical excipient comprising a mixture of sugar alcohol and chitin and/or chitin derivatives, a method for its preparation and use thereof.Type: ApplicationFiled: May 11, 2011Publication date: November 15, 2012Applicant: THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO.Inventors: Nidal H. Daraghmenh, Mahmoud M. Al Omari, Adnan A. Badwan
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Patent number: 8309535Abstract: The invention describes methods and compositions for alleviating recurrent medical afflictions for which anxiety may cause or exacerbate the affliction. A subject suffering from the affliction is treated with a combination of a pharmaceutical that enhances learning, and a second pharmaceutical recognized to be useful for treatment of the affliction. Representative afflictions include insomnia, erectile dysfunction, female sexual dysfunction, neuropathic pain, attention deficit disorder, and depression.Type: GrantFiled: November 30, 2010Date of Patent: November 13, 2012Inventors: Jason P. McDevitt, Michael Davis
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Publication number: 20120277180Abstract: Provided herein are methods and systems for identifying one or more cofactors such as vitamins for individuals based on the genetic makeup of the individual by detecting the presence or absence of at least one genetic variant, determining a predisposition to cofactor remediable condition, generating a personalized nutritional advice plan based on the genetic variant. Also provided herein are formulations of cofactors determined by the genetic make-up of the individual and methods of determining and producing these formulations.Type: ApplicationFiled: September 30, 2010Publication date: November 1, 2012Applicants: VITAPATH GENETICS, INC, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Nicholas Marini, Jasper Rine, Dennis Austin Gilbert, Bruce Cohen
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Publication number: 20120277179Abstract: The disclosure relates to an edible energy composition that provides physical and mental benefits when ingested.Type: ApplicationFiled: May 14, 2012Publication date: November 1, 2012Applicant: BioClinical Development Inc.Inventor: Manoj Bhargava
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Publication number: 20120269868Abstract: Disclosed is a nutritional supplement composition including effective amounts of Coenzyme Q10, fish oil, vitamin D and a pharmaceutically acceptable excipient. Described is a method of promoting nutritional health comprising administering a nutritional supplement composition including Coenzyme Q10, fish oil, vitamin D and a pharmaceutically acceptable excipient to a subject. The nutritional supplement composition may further include flax seed oil, borage oil, evening primrose oil, vitamin E, resveratrol, vitamin B6, vitamin B12, folic acid, piperine and combinations. In some embodiments, administering Administering the nutritional supplement may ameliorate nutrient depletion, or promote cardiovascular health, liver health, or both. The nutritional supplement may be used to promote nutritional health taking a cholesterol lowering drug. The nutritional supplement may be used to ameliorate nutrient depletion taking a cholesterol lowering drug. The cholesterol lowering drug may be a statin.Type: ApplicationFiled: April 18, 2012Publication date: October 25, 2012Inventor: Paul Joseph FAERSTEIN
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Patent number: 8293721Abstract: Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are potent CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In formula I, A-B is an arylamide moiety.Type: GrantFiled: June 16, 2008Date of Patent: October 23, 2012Assignee: Merck Sharpe & Dohme Corp.Inventors: Julianne A. Hunt, Ramzi F. Sweis, Peter J. Sinclair
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Publication number: 20120264704Abstract: The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.Type: ApplicationFiled: October 26, 2007Publication date: October 18, 2012Inventors: Kai Thede, Ingo Flamme, Felix Oehme, Jens-Kerim Ergüden, Friederike Stoll, Joachim Schuhmacher, Hanno Wild, Peter Kolkhof, Hartmut Beck, Metin Akbaba, Mario Jeske
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Patent number: 8288360Abstract: A novel method and composition for treating vitamin B12 deficiency mammals that fail to respond to oral vitamin B12 therapy.Type: GrantFiled: August 9, 2011Date of Patent: October 16, 2012Assignee: Emisphere Technologies, Inc.Inventors: Cristina Castelli, Laura Kragie
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Publication number: 20120258176Abstract: The invention discloses particulate complexes composed of chitosan, poly-glutamic acid, and at least one bioactive agent, wherein equal moles of the positively charged chitosan and the negatively charged poly-glutamic acid substrate form an electrostatic network enabling improved loading the bioactive agent.Type: ApplicationFiled: May 7, 2012Publication date: October 11, 2012Inventors: Hsing-Wen Sung, Zi-Xian Liao, Shu-Fen Peng, Hosheng Tu
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Patent number: 8273380Abstract: A beverage for minimizing or reducing jet lag symptoms preferably includes vitamin B3, vitamin B5, vitamin B6, vitamin B12, vitamin D, zinc, calcium, iodine, magnesium, manganese, ginseng, ginkgo biloba, grape seed extract, Echinacea extract and water. A method for minimizing or reducing jet lag symptoms including ingestion of the beverage by a traveler, one hour prior to a flight, and/or during the flight, and/or after a flight.Type: GrantFiled: May 19, 2009Date of Patent: September 25, 2012
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Publication number: 20120237480Abstract: The present invention relates to 2?-allene-substituted nucleoside derivatives of the general formula (I): As well as pharmaceutical compositions comprising such compounds and methods to treat or prevent an HIV infection, HBV infection, HCV infection or abnormal cellular proliferation, comprising administering said compounds or compositions. In addition, the present invention includes processes for the preparation of such compounds, and the related ?-D and ?-L-nucleoside derivatives.Type: ApplicationFiled: March 16, 2012Publication date: September 20, 2012Inventors: YAT SUN OR, Jun Ma, Guoqiang Wang, In Jong Kim, Jiang Long, Yao-Ling Qiu
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Publication number: 20120231089Abstract: A method for reversing stress-induced dysfunctions of a human autonomic nervous system in accordance with Methylation Priority Principle includes repeatedly administering a methylation-promoting composition composed to promote a hierarchy of methylation functions of the Methylation Priority Principle including uninterrupted methylation cycle recycling of homocysteine to methionine, and uninterrupted processing and removal of metabolic products of stress.Type: ApplicationFiled: April 26, 2012Publication date: September 13, 2012Inventor: Alan Robert Vinitsky
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Patent number: 8263667Abstract: A nutritional supplement for use in physiologically stressful conditions is disclosed. The nutritional supplement may include one or more of vitamin A, vitamin E, vitamin D3, vitamin C, vitamin B1, riboflavin, niacin, folic acid, vitamin B6, biotin, pantothenic acid, vitamin B12, magnesium, zinc, selenium, chromium, copper, iron, alpha lipoic acid, lutein and lycopene.Type: GrantFiled: March 8, 2011Date of Patent: September 11, 2012Assignee: Vertical Pharmaceuticals, Inc.Inventors: Steven A. Squashic, Kevin M Hudy, David C. Purdy
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Publication number: 20120225840Abstract: Hydroxytyrosol or olive juice containing hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1, B2, B3, B5, B6, and/or B12) and ginseng (preferably: root) extract can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.Type: ApplicationFiled: October 15, 2009Publication date: September 6, 2012Inventors: Ann Fowler, Angelika Friedel, Darko Knutti, Karin Kuratli, Daniel Raederstorff, Ying Wang-Schmidt, Karin Wertz
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Patent number: 8258125Abstract: A pharmaceutical composition including therapeutically effective amounts of at least one HMG-CoA reductase inhibitor present as a dyhydroxyacid salt and at least one additional therapeutic agent.Type: GrantFiled: June 20, 2008Date of Patent: September 4, 2012Inventor: Josefino B. Tunac
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Publication number: 20120219639Abstract: A nutritional supplement for patients having cardiovascular disease including heat failure. The nutritional supplement comprises vitamin C, vitamin D, vitamin B1, vitamin B2, vitamin B6, and folic acid, wherein the supplement is further characterized in that it does not contain vitamin A, vitamin K, or copper. In some embodiments, the supplement also contains omega fatty acids.Type: ApplicationFiled: May 10, 2012Publication date: August 30, 2012Applicant: Nephroceuticals, LLCInventor: John Wigneswaran
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Patent number: 8252768Abstract: Chemotherapeutic and Radiation sensitizing agents which target tumor cells, specifically, based on the elevation of enzyme pathways, provide highly selective drug therapy. These agents are combined with modulating doses of cytidine deaminase inhibitors to increase selectivity. Furthermore, high doses of these cytidine deaminase inhibitors have the potential of counteracting the aggressive and metastatic characteristics of pancreatic tumors. For tumors with high levels of cytidine deaminase, such as pancreatic tumors, this elevation provides a therapeutic approach with prodrugs that require deamination for their activation. For tumors with high levels of uridine/cytidine kinase, a different class of pyrimidine analogs can be activated selectively in tumors for a therapeutic advantage.Type: GrantFiled: May 27, 2009Date of Patent: August 28, 2012Assignee: University of MiamiInventor: Sheldon B. Greer
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Publication number: 20120190640Abstract: A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cyanocobalamin has a bioavailability of cyanocobalamin when administered intranasally of at least about 7% relative to an intramuscular injection of cyanocobalamin with the proviso that the solution is essentially free of mercury and mercury-containing compounds. The present invention is also directed towards a method for elevating the vitamin B12 levels in the cerebral spinal fluid (CSF) comprising administering, intranasally a sufficient amount of a mercury-free cyanocobalamin solution so as to increase the average ratio of vitamin B12 in the CSF to that in the blood serum (B12 CSF/B12 Serum×100) to at least about 1.Type: ApplicationFiled: July 22, 2011Publication date: July 26, 2012Applicant: PAR PHARMACEUTICALS INC.Inventors: Steven C. QUAY, Peter C. Aprile, Zenaida O. Go, Anthony P. Sileno
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Publication number: 20120183585Abstract: The various embodiments herein provide a gel based wound dressing comprising a lyophilized powder and a water-based solvent. The lyophilized powder comprises several nanoparticles and water miscible natural or synthetic polymers. The nanoparticles comprises pectin and a wound healing agent or an anti-microbial agent. The anti-microbial agent is nisin. The lyophilized powder and the water-based solvent are kept in two separate sealed packages and are mixed together before applying on a wound. The embodiments herein also provide a method of synthesizing the gel based wound dressing. The nano-particles control a release of the wound healing agent or the antimicrobial agent to a wound.Type: ApplicationFiled: February 25, 2012Publication date: July 19, 2012Inventors: Rassoul Dinarvand, Nasrin Samadi, Azade Taheri Borujeni
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Patent number: 8221799Abstract: The invention is directed to a method for administering antioxidant micronutrient formulations comprising multiple dietary and endogenous antioxidants, B-vitamins, vitamin D and minerals at appropriate dosages and dose schedules particularly chosen to produce long-term ‘optimal health’ effects in individuals of various age groups and occupations, with particular emphasis on reducing and/or eliminating acute and/or long term effects of environmental and physical stressors and toxic chemicals to which current Operating Forces and veterans of military service are or have been exposed.Type: GrantFiled: February 5, 2007Date of Patent: July 17, 2012Assignee: Premier Micronutrient CorporationInventors: Kedar N. Prasad, Gerald M. Haase, William C. Cole