C=o Other Than As Ketone Or Aldehyde Patents (Class 514/521)
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Patent number: 8193243Abstract: Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa.Type: GrantFiled: May 17, 2010Date of Patent: June 5, 2012Assignee: Neuroderm, Ltd.Inventors: Oron Yacoby-Zeevi, Mara Nemas
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Publication number: 20120122688Abstract: A composition contains an agricultural pesticide and an incompletely hydrated water soluble polymer suspended in a liquid medium.Type: ApplicationFiled: November 10, 2011Publication date: May 17, 2012Applicant: RHODIA OPERATIONSInventors: Dan Wu, Krishnamurthy Shanmuganandamurthy, Rajesh Goyal, Valerio Bramati
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Publication number: 20120122918Abstract: Compounds of formula (1) have antibacterial activity: wherein R represents hydrogen or 1, 2 or 3 optional substituents; W is ?C(R1)—; R1 is hydrogen and R2 is hydrogen, methyl, or fluorine; or R1 and R2 taken together are —CH2—, —CH2CH2, —O—, or, in either orientation, —O—CH2— or —OCH2CH2—; and R3 is a radical of formula -(Alk1)m-(Z)p-(Alk2)-Q.Type: ApplicationFiled: November 28, 2011Publication date: May 17, 2012Applicant: BIOTA SCIENTIFIC MANAGEMENT PTY LTDInventors: David Ryall BROWN, Ian COLLINS, Lloyd George CZAPLEWSKI, David John HAYDON
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Publication number: 20120122878Abstract: The invention concerns the combinations of an mGluR modulator, e.g. an mGluR5 modulator and at least one of L-dopa, a dopamine modulator, e.g. a dopamine agonist, a dopa decarboxylase inhibitor or a catechol-O-methyl transferase inhibitor.Type: ApplicationFiled: June 30, 2008Publication date: May 17, 2012Inventors: Baltazar Gomez-Mancilla, Fabrizio Gasparini
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Patent number: 8173702Abstract: A pesticidal composition containing: 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl 3-(2-cyano-1-propenyl)-2,2-dimethylcyclopropanecarboxylate, a saturated hydrocarbon having an initial boiling point of 150° C. or higher and a 95%-distillation temperature of 300° C. or lower, and at least one alkyl carboxylate ester selected from the group consisting of the following esters (i) to (iii): (i) alkyl alkylcarboxylate esters having 12 to 20 carbon atoms, (ii) dialkyl dicarboxylate esters having 12 to 20 carbon atoms, and (iii) trialkyl acetylcitrate esters having 12 to 20 carbon atoms; has an excellent pesticidal activity.Type: GrantFiled: March 27, 2007Date of Patent: May 8, 2012Assignee: Sumitomo Chemical Company, LimitedInventors: Masahiro Yamada, Yoshito Tanaka
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Patent number: 8158678Abstract: Novel derivatives of ?-cyano-?-naphthyl acrylates, sunscreen compositions including one or more ?-cyano-?-naphthyl acrylate derivatives are described herein. Also disclosed are methods for stabilizing a sunscreen composition and methods of filtering out ultra-violet light from a substrate by the addition of one or more of the foregoing ?-cyano-?-naphthyl acrylate derivatives.Type: GrantFiled: April 7, 2005Date of Patent: April 17, 2012Inventors: Craig A. Bonda, Anna Pavlovic
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Publication number: 20120083497Abstract: The present invention relates to methods, use and compositions for combating harmful fungi and bacteria in plants. More specifically, it relates to methods and compositions for controlling, preventing, or treating plant pathogens using UV filters for combating phytotoxin-producing fungi and/or bacteria, in particular, for combating harmful fungi and/or bacteria producing photodynamically active phytotoxins.Type: ApplicationFiled: March 25, 2010Publication date: April 5, 2012Inventors: Richard Riggs, Dieter Strobel, Jochen Prochnow, Helmut Herrmann, Michael Ishaque, Christian Bittner
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Patent number: 8142802Abstract: An insecticidal composition of Acephate and Cypermethrin with enhanced synergistic activity. Preferably, the insecticidal composition includes 0.1 to 25% w/w Cypermethrin active ingredient and 0.5 to 75% w/w Acephate active ingredient along with other ingredients to make dry flow, low compact, dust free granules.Type: GrantFiled: October 22, 2004Date of Patent: March 27, 2012Assignee: United Phosphorus, Ltd.Inventors: Prakash Mahadev Jadhav, Jaidev Rajnikant Shroff
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Publication number: 20120064140Abstract: Composite nanogranules from polymer/inorganic nanoparticle, especially first composite nanogranules which are formed from first polymer and inorganic nanoparticles, second composite nanogranules which are obtained by forming second polymer on the first composite nanogranules, third composite nanogranules which is obtained by forming third polymer on the second composite nanogranules, and Nth composite nanogranules which is obtained by forming Nth polymer on the (N?1)th composite nanogranules with the similar method, are disclosed. A composition comprising anyone of the composite nanogranules described above is disclosed. The preparation method thereof and use of the same are also disclosed.Type: ApplicationFiled: May 12, 2010Publication date: March 15, 2012Applicant: Wuxi Now Materials Corp.Inventors: Suping Qian, Yuhong Xu, Zhentian Fan, Yongtal Hou
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Patent number: 8128910Abstract: A pesticidal aerosol composition, containing 3-phenoxybenzyl ester compound represented by Formula (I): wherein, X represents a hydrogen atom or a cyano group; Z represents a hydrogen atom or a fluorine atom; and R1 and R2 each independently represent a hydrogen atom, a C1-C3 alkyl group that may be substituted with halogen atoms, or a halogen atom; 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl 3-(2-cyano-1-propenyl)-2,2-dimethylcyclopropanecarboxylate, an organic solvent, and a propellant has an excellent pesticidal activity.Type: GrantFiled: March 27, 2008Date of Patent: March 6, 2012Assignee: Sumitomo Chemical Company, LimitedInventor: Yoshito Tanaka
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Publication number: 20120047792Abstract: A composite pest barrier (10) comprising mesh sheeting (13) and a pest deterrent associated with the mesh sheeting. The mesh sheeting (13) typically comprises woven mesh sheeting. The pest deterrent comprises a pest resistant material. The pest deterrent may be associated with the mesh sheeting (13) in any suitable way. In one arrangement, the pest deterrent comprises a membrane (15) applied to the mesh sheeting, the membrane (15) carrying pest resistant material. In another arrangement, the pest deterrent comprises pest resistant material applied to the mesh sheeting (15). In yet another arrangement, the pest deterrent is incorporated into the mesh sheeting (15) itself.Type: ApplicationFiled: March 25, 2010Publication date: March 1, 2012Applicant: TMA CORPORATION PTY LTDInventors: Tonio Umberto Sala, Clive Roy Denis Cumming, Geoffrey Wayne Richardson
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Publication number: 20120039823Abstract: Use of topical, cosmetic or dermatological preparations with a content of (1R,2S,5R)-2-isopropyl-5-methyl-N-(2-(pyridin-2-yl)ethylcyclohexanecarboxamide and/or (1R,2S,5R)-N-(4-(cyanomethyl)-phenyl)-2-isopropyl-5-methylcyclohexyl carboxamide for reducing itching.Type: ApplicationFiled: February 3, 2009Publication date: February 16, 2012Applicant: BEIERSDORF AGInventors: Ludger Kolbe, Julia Eckert, Gitta Neufang, Stefanie Knaupmeier (Hoeltkemeier), Nils Peters
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Patent number: 8114897Abstract: A pesticidal composition containing 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl 3-(2-cyano-1-propenyl)-2,2-dimethylcyclopropanecarboxylate and 1-(2-chloro-1,3-thiazolyl)methyl-3-methyl-2-nitroguanidine has a high pesticidal activity.Type: GrantFiled: February 20, 2008Date of Patent: February 14, 2012Assignee: Sumitomo Chemical Company, LimitedInventor: Satoshi Sembo
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Publication number: 20110301126Abstract: The present invention relates to a pesticidal control device that includes at least one pesticidal active ingredient, cellulose fibers, and a polymer or polymer matrix. he combination of the cellulose fibers with the polymer allows for a higher loading of liquid pesticidal active ingredients within the pesticidal control device, maintains the active ingredient within the control device during transportation, storage and handling, and provides higher efficacy or control of pests during treatment. The pesticidal control device may be an ear tag, collar, or bee strip.Type: ApplicationFiled: January 19, 2010Publication date: December 8, 2011Applicant: Bayer Animal Health GmbHInventors: Robert G. Pennington, John Rose, Jochem Rueter
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Publication number: 20110275577Abstract: The present invention relates to caffeic acid analog compounds and methods which may be useful for regeneration, cellular programming, and the treatment of dermatologic, gynecologic, and genital diseases such as inflammatory dermatologic conditions, dysplasia, neoplasia, in situ carcinoma, invasive carcinoma, lichen sclerosus, lichen planus, vaginal dysplasia, vaginal carcinoma, vulvar dysplasia, vulvar carcinoma, cervical dysplasia, cervical carcinoma, and Kaposi's sarcoma.Type: ApplicationFiled: January 10, 2011Publication date: November 10, 2011Applicant: Moleculin, LLCInventors: Anna Priebe, Waldemar Priebe
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Publication number: 20110275583Abstract: Novel active compound combinations comprising compounds of the formula (I) and compounds of the formula (II) have very good insecticidal and acaricidal properties.Type: ApplicationFiled: April 28, 2011Publication date: November 10, 2011Applicant: Bayer CropScience AGInventors: Thomas BRETSCHNEIDER, Heike HUNGENBERG, Martin Füsslein
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Publication number: 20110275710Abstract: The present invention provides an agricultural pesticide formulation of reduced toxicity and high dispersibility, and a process for making the same.Type: ApplicationFiled: May 7, 2010Publication date: November 10, 2011Applicant: United Phosphorus Inc.Inventor: Prakash Jadhav
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Publication number: 20110269833Abstract: Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa.Type: ApplicationFiled: December 7, 2010Publication date: November 3, 2011Inventors: Oron Yacoby-Zeevi, Mara Nemas
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Publication number: 20110256195Abstract: The present invention relates to an insecticide-containing polymeric material containing at least one embedded insecticidally active ingredient in the polymeric matrix and having excellent biological activity, and also to the products produced from this polymer and to their use for protecting humans, animals and plants against arthropods, particularly for controlling insects.Type: ApplicationFiled: April 14, 2011Publication date: October 20, 2011Applicant: Bayer CropScience AGInventors: Maren Heinemann, Thomas Bocker, Karin Horn, Guenther Nentwig, Rainer Sonneck, Thomas Konig
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Publication number: 20110256198Abstract: The present invention relates to an insecticide-containing fabric containing at least one embedded insecticidally active ingredient in the polymeric matrix and having excellent wash resistance, and also to the products produced from this fabric and to their use for protecting humans, animals and plants against arthropods, particularly for controlling insects.Type: ApplicationFiled: April 14, 2011Publication date: October 20, 2011Applicant: Bayer CropScience AGInventors: Rainer Sonneck, Thomas Bocker, Karin Horn, Guenther Nentwig, Maren Heinemann, Thomas Konig
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Publication number: 20110256200Abstract: A process for the impregnation of non-living-materials comprises the step of impregnating the non-living material with an aqueous formulation free of organic solvents which comprises one or more pesticides and a polymeric binder comprising one or more fluorinated polyacrylates having a fluorine content (based on the solid content of the polymeric binder) of at least 10% by weight.Type: ApplicationFiled: December 21, 2009Publication date: October 20, 2011Applicant: BASF SEInventors: Michael Ishaque, Arnold Kraushaar, Egon Weinmueller
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Patent number: 8039484Abstract: Diaryl ethers in which one of the aryl groups is a phenyl fused to a cycloalkyl or heterocyclic ring, to which is attached an acetic acid group, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that often accompany this disease, including insulin resistance, obesity and lipid disorders.Type: GrantFiled: October 26, 2007Date of Patent: October 18, 2011Assignee: Merck Sharp & Dohme Corp.Inventors: Min Ge, Songnian Lin, Shawn P. Walsh, Lihu Yang, Changyou Zhou
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Publication number: 20110237665Abstract: The present invention relates to an agrochemical composition comprising pesticide and UV absorber, and the abovementioned UV absorbers. The invention furthermore relates to the use of the UV absorbers in agrochemical compositions. It moreover relates to a method of controlling phytopathogenic fungi and/or undesirable plant growth and/or undesirable insect or mite infestation and/or of regulating plant growth.Type: ApplicationFiled: November 30, 2009Publication date: September 29, 2011Applicant: BASF SEInventors: Andrea Misske, Christian Bittner, Michael Ishaque, Markus Hoffmann, Richard Riggs, Sens Ruediger, Andre Kabat, Sylke Haremza, Douglas D. Anspaugh, David M. Terry
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Publication number: 20110229561Abstract: There is provided an extended release pharmaceutical composition comprising from about 200 mg to about 1000 mg of entacapone or salts thereof, optionally with other pharmaceutically acceptable excipients. The invention also provides an extended release pharmaceutical composition comprising triple combination of from about 30 mg to about 300 mg of levodopa, 10 mg to about 100 mg of carbidopa and 200 mg to about 1000 mg of entacapone or salts thereof, optionally with other pharmaceutically acceptable excipients. The invention also relates to process of preparation of such compositions.Type: ApplicationFiled: August 22, 2009Publication date: September 22, 2011Inventors: Ritesh Kapoor, Munish Talwar, Sanjay Mate, Manoj Mashalkar, Girish Kumar Jain, Mandar Kodgule
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Publication number: 20110230446Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.Type: ApplicationFiled: May 25, 2011Publication date: September 22, 2011Applicants: Axys Pharmaceuticals, Inc., Merck Canada Inc.Inventors: Christopher I. Bayly, Cameron Black, Serge Leger, Chun Sing Li, Dan McKay, Chirstophe Mellon, Jacques Yves Gauthier, Vouy-Linh Truong, Cheuk Lau, Michel Therien, Michael J. Green, Bernard L. Hirschbein, James William Janc, James T. Palmer, Chitra Baskaran
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Publication number: 20110229566Abstract: There is provided a single unit oral dose pharmaceutical composition comprising a) levodopa or salts thereof from about 50 mg to about 300 mg in extended release form, b) carbidopa or salts thereof from about 10 mg to about 100 mg in extended release and c) entacapone or salts thereof from about 100 mg to about 1000 mg in immediate release form, optionally with other pharmaceutically acceptable excipients. The invention also relates to process of preparation of such compositions.Type: ApplicationFiled: August 22, 2009Publication date: September 22, 2011Inventors: Yatendra Kumar Gupta, Girish Kumar Jain, Munish Talwar, Manoj Mashalkar
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Publication number: 20110200658Abstract: A process for making microcapsules comprising i) forming a solution of a cross-linker in a liquid; ii) forming a slurry of a surface-modified particulate inorganic material in an aqueous medium; and iii) dispersing the solution of step i) in the slurry of step ii) and causing or allowing the cross-linker to react with the surface-modified particulate inorganic material so as to form a cross-linked microcapsule wall.Type: ApplicationFiled: March 13, 2009Publication date: August 18, 2011Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Patrick Joseph Mulqueen, Philip Taylor, Gittins David lan
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Publication number: 20110195042Abstract: The present disclosure describes methods for enhancing an overall cooling sensation of an oral mucosa comprising administering a liquid composition comprising a thickening agent and/or a mucoadhesive polymer, a non-menthol coolant; and contacting the oral mucosa with the liquid composition. The disclosure also describes the liquid compositions.Type: ApplicationFiled: February 7, 2011Publication date: August 11, 2011Inventors: Thomas Edward Huetter, Tracy L. Grosick
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Publication number: 20110184040Abstract: The present invention relates to a method for controlling arthropods comprising the application of an aqueous gel which contains an insecticide, an attractant and a thickener, wherein the aqueous gel is applied in the form of spots on fruit trees. The invention further relates to an aqueous gel comprising an insecticide, an attractant, a thickener, a humectant and a feeding stimulant. The invention also relates to a concentrated gel for preparing the aqueous gel.Type: ApplicationFiled: January 21, 2011Publication date: July 28, 2011Applicant: BASF SEInventors: Claude Taranta, Tatjana Levy, Ouidad Benlahmar, Marc Nolte, Thomas Kröhl, Christoph Randt, Thomas Bork, Wolfgang Meier, Clark D. Klein, Tiffany Hennessey
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Publication number: 20110165213Abstract: An insecticidal polymer matrix containing HDPE (high density polyethylene), LDPE (low density polyethylene), preferably containing PBO (Piperonyl Butoxide) and DM (Deltamethrin), wherein the ratio of the contents of HDPE to LDPE is between 5 and 20 and most preferably between 8 and 10. The matrix is highly useful for bed nets against mosquitoes.Type: ApplicationFiled: July 23, 2009Publication date: July 7, 2011Inventors: Mikkel Vestergaard Vestergaard Frandsen, Michael Stanley Pedersen, Matthieu Zellweger, Sebastien Gouin, Sicco Dirk Roorda, Thi Quynh Chi Phan
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Patent number: 7968598Abstract: An ester compound represented by the formula (1): wherein R represents a C1-C4 alkyl group or a C3-C4 alkenyl group, and A represents a single bond or an oxygen atom, has an excellent pest controlling efficacy, and it is useful as an active ingredient of a pest controlling agent.Type: GrantFiled: February 27, 2008Date of Patent: June 28, 2011Assignee: Sumitomo Chemical Company, LimitedInventor: Tatsuya Mori
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Publication number: 20110152315Abstract: There is provided novel compounds capable of modulating the G-protein-coupled receptor GPR40, compositions comprising the compounds, and methods for their use for controlling insulin levels in vivo and for the treatment of conditions such as type I1 diabetes, hypertension, ketoacidosis, obesity, glucose intolerance, and hypercholesterolemia and related disorders associated with abnormally high or low plasma lipoprotein, triglyceride or glucose levels.Type: ApplicationFiled: July 23, 2009Publication date: June 23, 2011Inventors: Trond Ulven, Elisabeth Christiansen
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Publication number: 20110144170Abstract: The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl zing substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the Fc?RIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.Type: ApplicationFiled: February 18, 2011Publication date: June 16, 2011Inventors: Mark Phillip Hogarth, Geoffrey Allan Pietersz, Gerard Peter Moloney
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Publication number: 20110136878Abstract: A pest control agent containing a compound represented by the following Formula (1), wherein A represents a carbon atom, a nitrogen atom, or the like, K represents a non-metal atom group necessary for forming a cyclic linking group derived from a 5- or 6-membered aromatic ring, in combination with A and two carbon atoms to which A bonds, X represents a hydrogen atom, a halogen atom, or the like, n represents an integer of from 0 to 4, T represents —C(=G1)-Q1 (wherein G1 and G2 represent an oxygen atom or the like, Q1 represents a phenyl group which may have a substituent, a heterocyclic group which may have a substituent, or the like), or the like, Q2 represents a phenyl group or the like, G3 represents an oxygen atom or the like, and R1 and R2 each independently represent a hydrogen atom, a C1-C6 alkyl group, or a group represented by -L-D, or the like (provided that at least either R1 or R2 represents a group represented by -L-D); as an active ingredient exhibits an excellent effect.Type: ApplicationFiled: June 29, 2009Publication date: June 9, 2011Applicant: Mitsui Chemicals Agro., Inc.Inventors: Yumi Kobayashi, Hiroyuki Katsuta, Michikazu Nomura, Hidetaka Tsukada, Atsushi Hirabayashi, Hidenori Daido, Yusuke Takahashi, Shinichi Banba
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Publication number: 20110130430Abstract: The present invention concerns polymeric material containing at least an embedded insecticidally active ingredient and an additive, which are released at room temperature. It similarly concerns materials produced from this polymer, for example in the form of self-supporting film/sheet, threads, wovens, fabrics, textiles, nets, curtains and pellets. The invention further concerns processes for producing such polymeric material and also the use of the self-supporting film/sheet, threads, wovens, fabrics, textiles and nets and curtains produced from the material for protecting humans, animals and plants and buildings, machines and packaging against arthropods, particularly for controlling insects.Type: ApplicationFiled: April 1, 2009Publication date: June 2, 2011Applicant: Bayer CropScience AGInventors: Rainer Sonneck, Thomas Böcker, Karin Horn, Guenther Nentwig, Maren Heinemann, Thomas König
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Publication number: 20110130289Abstract: Agrochemical compositions comprising (a) one or more branched alkyl polyglycosides, and (b) one or more biocides are disclosed. The compositions display improved solubility in water, and reduced foam generation.Type: ApplicationFiled: November 29, 2010Publication date: June 2, 2011Applicant: COGNIS IP MANAGEMENT GMBHInventors: Barbara Stefl, Jianhua Mao
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Publication number: 20110117155Abstract: Pesticide strips used to control parasitic mites in honeybees. The pesticide strips are designed to have a lifetime or period of existence, after which the strip no longer exists in its original form. The strip breaks down, such as by disintegration, dissolving, decomposition, being eaten or carrier away, or otherwise degrading over time, so that at the end of the recommended lifetime, the strip is no longer in its original form. In most embodiments, at least 50% of the strip is no longer present, and in other embodiments at least 75% of the strip is no longer present. Preferably, at the end of the recommended lifetime, the strip no longer exists, at least the body of the strip that included the active ingredient. With this design, the strip does not provide extended low-dose pesticide that can be detrimental in treating the mites.Type: ApplicationFiled: November 17, 2010Publication date: May 19, 2011Inventor: Stuart Volby
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Publication number: 20110117159Abstract: The present invention relates to a method of treating pulmonary arterial hypertension by administering a therapeutically effective amount of a selective JAK2 inhibitor to a patient in need thereof.Type: ApplicationFiled: February 28, 2007Publication date: May 19, 2011Inventor: Lawrence S. Zisman
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Publication number: 20110098322Abstract: The present invention provides compounds that can inhibit the activity of soluble epoxide hydrolases. In particular, the present invention provides compounds of Formula I.Type: ApplicationFiled: August 5, 2008Publication date: April 28, 2011Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: James R. Sanborn, Bruce D. Hammock, Sung Hee Hwang, Paul D. Jones, Christophe Morisseau
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Publication number: 20110091531Abstract: A liquid cooling composition, which is a mixture of at least one primary cooling compound, at least one different secondary cooling compound and at least one ingestible non-polar solvent for the primary cooling compound, the weight ratios of primary cooling compound:secondary cooling compound:solvent being 1:1.5-2.25:2-4.4.Type: ApplicationFiled: May 19, 2009Publication date: April 21, 2011Applicant: GIV AUDAN SAInventors: Stefan Michael Furrer, Karen Ann Bell, Fabio Campanile, Aloysius Lambertus Doorn, Joshua Andrew Hagen
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Publication number: 20110091558Abstract: The present invention relates to single oral dose pharmaceutical compositions comprising a combination of entacapon, levodopa and carbidopa, or salts thereof along with one or more sugar alcohols, wherein the entacapone is co-micronized with one or more sugar alcohols. The composition of the invention exhibits bioequivalence to commercially available entacapone, levodopa and carbidopa combination formulation marketed under the trade name Stalcvo200®. The invention also relates to processes for making such compositions.Type: ApplicationFiled: February 6, 2009Publication date: April 21, 2011Applicant: WOCKHARDT RESEARCH CENTREInventors: Munish Talwar, Ritesh Kapoor, Manoj Mashalkar, Girish Kumar Jain
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Publication number: 20110086845Abstract: This invention provides agents, compositions, pharmaceutical compositions and methods for treating or slowing the progression of a neurodegenerating disease, such as Alzheimer's disease and a demyelinating disease.Type: ApplicationFiled: October 18, 2010Publication date: April 14, 2011Applicant: The Board of Trustees of the University of IllinoisInventors: Douglas L. Feinstein, Maria Vittoria Simonini, Sergey Kalinin, Paul E. Polak
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Publication number: 20110065789Abstract: An ester compound represented by the formula (1): wherein R represents a C1-C4 alkyl group or a C3-C4 alkenyl group, and A represents a single bond or an oxygen atom, has an excellent pest controlling efficacy, and it is useful as an active ingredient of a pest controlling agent.Type: ApplicationFiled: November 17, 2010Publication date: March 17, 2011Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventor: Tatsuya MORI
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Publication number: 20110052681Abstract: The present invention relates to pharmaceutical compositions comprising entacapone or pharmaceutically acceptable salts thereof along with one or more sugar alcohols; wherein the entacapone is co-micronized with one or more sugar alcohols. The invention also relates to processes of making such compositions.Type: ApplicationFiled: February 6, 2009Publication date: March 3, 2011Inventors: Ritesh Kapoor, Sanjay Mate, Munish Talwar, Girish Kumar Jain
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Patent number: 7875744Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.Type: GrantFiled: August 28, 2009Date of Patent: January 25, 2011Assignee: Janssen Pharmaceutica NVInventors: Gee-Hong Kuo, Rui Zhang, Aihua Wang, Alan DeAngelis, Keith Demarest, Patricia Pelton
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Patent number: 7863327Abstract: Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.Type: GrantFiled: May 3, 2005Date of Patent: January 4, 2011Assignee: Trustees of Dartmouth CollegeInventors: Gordon W. Gribble, Tadashi Honda, Michael B. Sporn, Nanjoo Suh
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Publication number: 20100331406Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.Type: ApplicationFiled: September 1, 2010Publication date: December 30, 2010Inventors: Alan DEANGELIS, Keith T. Demarest, Gee-Hong Kuo, Patricia Pelton, Aihua Wang, Rui Zhang
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Publication number: 20100322875Abstract: Disclosed is 1) a method for greatly increasing the solubility of useful actives in siloxane matrix-forming preparations, and 2) the associated preparations, themselves. Volatilizing coagents are utilized to give novel gels containing heretofore siloxane-insoluble additives.Type: ApplicationFiled: June 18, 2009Publication date: December 23, 2010Applicant: Advanced Bio-Technologies, Inc.Inventor: Paul Guilbaud
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Publication number: 20100310563Abstract: Methods are provided for treating a subject with a cellular proliferative disorder that include administering to the subject a therapeutically effective amount of a JAK2 inhibitor and a therapeutically effective amount of a TNF-alpha inhibitor. In addition, methods are provided herein for determining if a subject with a cellular proliferative disorder would benefit from treatment with an agent that inhibits tumor necrosis factor (TNF)-alpha. Methods are also provided for identifying an agent of use in treating a subject with a cellular proliferative disorder or with a predisposition for cellular proliferative disorder. The methods include contacting an isolated cell expressing an activating mutation in the JAK2 protein with a test agent, and detecting the amount of tumor necrosis factor (TNF)-alpha produced by the cell.Type: ApplicationFiled: November 28, 2008Publication date: December 9, 2010Inventors: Thomas G.P. Bumm, Michael W.N. Deininger
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Publication number: 20100298356Abstract: Compounds of the general formula (I), wherein the substituents are as defined in claim 1, are useful as fungicides.Type: ApplicationFiled: September 3, 2008Publication date: November 25, 2010Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Fiona Kessabi Murphy, Hans-Georg Brunner, Renaud Beaudegnies, Laura Quaranta, Frederik Cederbaum, Jayant Umarye