The Cyano Is Bonded Directly To A Benzene Ring Patents (Class 514/522)
  • Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity
    Publication number: 20040224991
    Abstract: The present invention is related to the preparation and pharmaceutical use of novel benzamide derivatives as defined in the specification of formula (I) as histone deacetylase inhibitors (HDACI), their preparations and the methods of using these compounds or their pharmaceutically acceptable salt in the treatment of cell proliferative diseases, e.g. cancer and psoriasis.
    Type: Application
    Filed: February 2, 2004
    Publication date: November 11, 2004
    Inventors: Xian-Ping Lu, Zhibin Li, Aihua Xie, Leming Shi, Boyu Li, Zhiqiang Ning, Song Shan, Tuo Deng, Weiming Hu
  • Diphenylurea compounds
    Publication number: 20040224993
    Abstract: Compound of formula (I): 1
    Type: Application
    Filed: June 7, 2004
    Publication date: November 11, 2004
    Inventors: Gilbert Lavielle, Olivier Muller, Mark Millan, Anne Dekeyne, Mauricette Brocco
  • Acylated 6,7,8,9-tetrahydro-5H-benzocycloheptenyl amines and their use as pharmaceutical agents
    Publication number: 20040225013
    Abstract: The present invention relates to compounds according to the general formula (I), 1
    Type: Application
    Filed: June 3, 2004
    Publication date: November 11, 2004
    Applicant: AVENTIS PHARMA DEUTSCHLAND GMBH
    Inventors: Hartmut Strobel, Paulus Wohlfart
  • Compounds having fungicidal activity and processes to make and use same
    Patent number: 6815556
    Abstract: A compound according to formula one that is useful as a fungicide is provided. Additionally, processes to make and use same are provided.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: November 9, 2004
    Assignee: Dow AgroSciences LLC
    Inventors: Carla Jean Rasmussen Klittich, Jeannie Rachel Cetusic, Marilene Tenguan Iamauti, Irene Mae Morrison, Michael Thomas Sullenberger, William Chi-Leung Lo, Ann Marie Buysse, Brent Jeffrey Rieder, John Todd Mathieson, Monica Britt Olson, Michael John Ricks
  • Asthma and allergic inflammation modulators
    Publication number: 20040220237
    Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.
    Type: Application
    Filed: December 19, 2003
    Publication date: November 4, 2004
    Inventors: Zice Fu, Alan Xi Huang, Jiwen Liu, Julio C. Medina, Michael J. Schmitt, H. Lucy Tang, Yingcai Wang, Qingge Xu
  • Carboxylic acid derivative and medicine comprising salt or ester of the same
    Publication number: 20040214888
    Abstract: The present invention provides novel carboxylic acid derivatives useful as an insulin sensitizer, a salt thereof or a hydrate of them, and a medicament comprising the derivative as the active ingredient.
    Type: Application
    Filed: December 3, 2003
    Publication date: October 28, 2004
    Inventors: Fumiyoshi Matsuura, Eita Emori, Masanobu Shinoda, Richard Clark, Shunji Kasai, Hideki Yoshitomi, Kazuto Yamazaki, Takashi Inoue, Sadakazu Miyashita, Taro Hihara
  • Process for the preparation of aniline-derived thyroid receptor ligands
    Patent number: 6806381
    Abstract: Provided are processes for the synthesis of aniline derivatives, specifically certain aniline derivatives which have activity as thyroid receptor ligands.
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: October 19, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ramakrishnan Chidambaram, Joydeep Kant, Raymond E. Weaver, Jurong Yu, Arun Ghosh
  • Multi-layer barrier preventing wood pest access to wooden structures
    Patent number: 6803051
    Abstract: A method and device are disclosed which prevent the intrusion of insects onto wood structures by using a barrier capable of retaining pesticide. In the disclosed method, the barrier maintains a minimal effective level of insecticide for a predetermined period of time.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: October 12, 2004
    Assignee: Battelle Memorial Institute K1-53
    Inventors: Peter Van Voris, Dominic A. Cataldo, Frederick G. Burton
  • Ligands of adenine nucleotide translocase (ANT) and compositions and methods related thereto
    Publication number: 20040198777
    Abstract: Compounds which have utility in the treatment of conditions associated with altered mitochondrial function.
    Type: Application
    Filed: December 19, 2003
    Publication date: October 7, 2004
    Applicant: MitoKor, Inc.
    Inventors: Soumitra S. Ghosh, Yazhong Pei, Xiao-Qing Tang
  • Compositions and method for treating microbial and parasitic infections in cattle and other animals
    Publication number: 20040198704
    Abstract: Novel formulations combining an antiparasitic compounds, such as an avermectin, with a fluorinated chloramphenicol or thiamphenicol derivative antibiotic such as Florfenicol are disclosed. Methods for using such formulations in the treatment and prevention of infectious diseases of bovines and swine, including bovine respiratory disease and parasitic infections are also disclosed.
    Type: Application
    Filed: April 2, 2004
    Publication date: October 7, 2004
    Applicant: Schering Corporation
    Inventors: Dale E. Shuster, David G. Sawutz, Kanwal J. Varma
  • Ligands of adenine nucleotide translocase (ANT) and compositions and methods related thereto
    Publication number: 20040192740
    Abstract: Compounds which have utility in the treatment of conditions associated with altered mitochondrial function.
    Type: Application
    Filed: December 19, 2003
    Publication date: September 30, 2004
    Applicants: MitoKor, Inc., Pfizer Inc.
    Inventors: Soumitra S. Ghosh, Yazhong Pei, Xiao-Qing Tang, Spiros Liras, Michael K. Ahlijanian
  • Cannabinoid receptor ligands
    Publication number: 20040186148
    Abstract: There are disclosed compounds of the formula I 1
    Type: Application
    Filed: March 18, 2004
    Publication date: September 23, 2004
    Applicant: Schering Corporation
    Inventors: Bandarpalle B. Shankar, Razia K. Rizvi, Joseph A. Kozlowski, Neng-Yang Shih
  • Compositions and method for treating infection in cattle and swine
    Patent number: 6790867
    Abstract: Novel formulations combining a non-steroidal anti-inflammatory drug (NSAID) such as flunixin, with a fluorinated chloramphenicol or thiamphenicol derivative antibiotic such as florfenicol are disclosed. Methods for using such formulations in the treatment and prevention of infectious diseases of bovines and swine, including bovine respiratory disease and swine respiratory disease, are also disclosed.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: September 14, 2004
    Assignee: Schering-Plough Animal Health Corporation
    Inventors: Raul E. Kohan, Kanwal J. Varma, Robert D. Simmons, Abu Huq, Keith A. Freehauf
  • Cycloalkyl containing anilide ligands for the thyroid receptor
    Publication number: 20040176425
    Abstract: Novel thyroid receptor ligands are provided having the general formula I 1
    Type: Application
    Filed: January 23, 2004
    Publication date: September 9, 2004
    Inventors: William N. Washburn, Wei Meng
  • Propionic acid derivatives
    Publication number: 20040176445
    Abstract: The present application relates to novel potent PPAR-alpha-activating compounds for treating, for example, coronary heart disease, and to their preparation.
    Type: Application
    Filed: March 9, 2004
    Publication date: September 9, 2004
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Klaus Urbahns, Michael Woltering, Susanne Nikolic, Josef Pernerstorfer, Berthold Hinzen, Elke Dittrich-Wengenroth, Hilmar Bischoff, Claudia Hirth-Dietrich, Klemens Lustig
  • Pesticide
    Publication number: 20040176369
    Abstract: Composition for controlling insects and representatives of the order Acarina, which comprises a combination of variable amounts of one or more compounds of the formula 1
    Type: Application
    Filed: March 16, 2004
    Publication date: September 9, 2004
    Inventors: Robert Senn, Peter Maienfisch, Peter Wyss
  • Inhibitors of human tumor-expressed CCXCKR2
    Publication number: 20040171655
    Abstract: Pharmaceutical compositions containing organic compounds or salts thereof that serve as modulators for the SDF-1 or I-TAC chemokines are disclosed. The compounds and compositions are useful in the treatment of cancer, especially in the inhibition of cancer proliferation, growth, and metastasis. Methods of interfering with SDF-1 and/or I-TAC binding to the CCXCKR2 receptor and treating cancer using the compounds and pharmaceutical compositions of the present invention are also disclosed.
    Type: Application
    Filed: December 22, 2003
    Publication date: September 2, 2004
    Inventors: Anita Melikian, Jennifer Burns, Brian E. McMaster, Thomas Schall, J.J. Wright
  • Haloacetamide and azide substituted compounds and methods of use thereof
    Publication number: 20040167103
    Abstract: The present invention relates to a novel class of androgen receptor targeting agents (ARTA), which contain a haloacetamide or azide moiety and are alkylating agents.
    Type: Application
    Filed: July 10, 2003
    Publication date: August 26, 2004
    Inventors: James T. Dalton, Duane D. Miller, Huiping Xu, Vipin Nair
  • Carboxyalkoxy-substituted acyl-carboxyphenylurea derivatives and their use as medicaments
    Publication number: 20040157922
    Abstract: Carboxyalkoxy-substituted acyl-carboxyphenylurea derivatives and their use as medicaments
    Type: Application
    Filed: October 6, 2003
    Publication date: August 12, 2004
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Elisabeth Defossa, Dieter Kadereit, Thomas Klabunde, Hans-Joerg Burger, Andreas Herling, Karl-Ulrich Wendt, Erich Von Roedern, Karl Schoenafinger, Alfons Enhsen
  • Heterocyclically substituted benzoylureas, process for their preparation and their use as pharmaceuticals
    Publication number: 20040152743
    Abstract: The invention relates to heterocyclically substituted benzoylureas and also to their physiologically tolerated salts and physiologically functional derivatives.
    Type: Application
    Filed: July 11, 2003
    Publication date: August 5, 2004
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Karl Schoenafinger, Elisabeth Defossa, Dieter Kadereit, Erich Von Roedern, Thomas Klabunde, Hans-Joerg Burger, Andreas Herling, Karl-Ulrich Wendt
  • Synergistic compositions for the selective control of tumor tissue
    Publication number: 20040147493
    Abstract: According to the invention, compositions are made available which have a strong cytotoxic effect which is largely selective on tumor tissue. The invention is based on the fact that certain benzoic acid derivatives have a strong synergistic effect as a mixture and destroy cancer cells selectively in a pH range of 7 or below, such as from 6.5 to 7.
    Type: Application
    Filed: November 17, 2003
    Publication date: July 29, 2004
    Inventor: Werner Kreutz
  • Haloacetamide and azide substituted compounds and methods of use thereof
    Publication number: 20040147489
    Abstract: The present invention relates to a novel class of androgen receptor targeting agents (ARTA), which contain a haloacetamide or azide moiety and are alkylating agents.
    Type: Application
    Filed: February 24, 2003
    Publication date: July 29, 2004
    Inventors: James T. Dalton, Duane D. Miller
  • IL-8 receptor antagonists
    Patent number: 6767922
    Abstract: This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: July 27, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Katherine Louisa Widdowson, Qi Jin
  • Compounds
    Publication number: 20040138300
    Abstract: The present invention releates to certain novel guanidine or amidine acid derivatives and analogs, to a process for preparing such compounds, having the utility in clinical conditions associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.
    Type: Application
    Filed: October 17, 2003
    Publication date: July 15, 2004
    Inventors: Krister Bamberg, Lanna Li
  • Method of treating neurodgenerative disorders of the retina and optic nerve head
    Publication number: 20040132773
    Abstract: The use of 3-benzolphenylacetic acids and derivatives, including nepafenac, to treat neurodegenerative retinal disorders is disclosed.
    Type: Application
    Filed: February 14, 2003
    Publication date: July 8, 2004
    Inventors: Daniel A Gamache, Gustav Graff, John M Yanni, Michael A Kapin
  • Glucagon antagonists/inverse agonists
    Publication number: 20040127560
    Abstract: Novel compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein a glucagon antagonistic action is beneficial, such as hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism and obesity.
    Type: Application
    Filed: November 13, 2003
    Publication date: July 1, 2004
    Inventors: Peter Madsen, Jesper Lau, Anthony Ling
  • Benzophenones as inhibitors of reverse transcriptase
    Publication number: 20040122064
    Abstract: The present invention is directed to benzophenone compounds useful in the inhibition of HIV reverse transcriptase, particularly its resistant varieties.
    Type: Application
    Filed: February 5, 2004
    Publication date: June 24, 2004
    Inventor: Joseph Howing Chan
  • Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
    Publication number: 20040116518
    Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases and cerebral vasospasm, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
    Type: Application
    Filed: December 1, 2003
    Publication date: June 17, 2004
    Applicant: Abbott Laboratories
    Inventor: Indrani W. Gunawardana
  • Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
    Publication number: 20040102636
    Abstract: This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
    Type: Application
    Filed: February 1, 2002
    Publication date: May 27, 2004
    Applicant: BAYER CORPORATION
    Inventors: Scott Miller, Martin Osterhout, Jacques Dumas, Uday Khire, Timothy B. Lowinger, William J. Scott, Roger A. Smith, Jill E. Wood, David E. Gunn, Holia Hatoum-Mokdad, Marell Rodriguez, Robert Sibley, Ming Wang, Tiffany Turner, Catherine Brennan
  • N-benzoylureidocinnamic acid derivatives, processes for preparing them and their use
    Publication number: 20040102518
    Abstract: The invention relates to N-benzoylureidocinnamic acid derivatives and to their physiologically tolerated salts and physiologically functional derivatives.
    Type: Application
    Filed: June 6, 2003
    Publication date: May 27, 2004
    Applicant: Aventis Pharma AG
    Inventors: Karl Schoenafinger, Elisabeth Defossa, Dieter Kadereit, Erich Von Roedern, Thomas Klabunde, Hans-Joerg Burger, Andreas Herling, Karl-Ulrich Wendt
  • Phenyl derivatives and their use in the treatment of thromboembolic disorders or tumours
    Publication number: 20040092517
    Abstract: Compounds of the formula (I) in which R1 is CN, or C(═NH)—NH2, CON(R3)2 or [C(R4)2]nN(R3)2, each of which is unsubstituted or monosubstituted by C(═O)R3, COOR3, or3 or by a conventional amino-protecting group, or W is —NR3CO—, —NR3COC(R4)2, NR3C(R4)2) or —C(R4)2NR3C(4)2—, X is —C(R3)2—, —[C(R3)2]2—, —C(R—3)2O— or —C(R3)2NR3, Y is alkylene, cycloalkylene, Het-diyl or Ar-diyl, T is OR3, N(R3)2, N(R3)2CON(R3)2, a monocyclic or bicyclic, saturated, unsaturated or aromatic heterocyclic radical having from 1 to 4 N, O and/sor S atoms which is unsubstituted or monosubstituted, disubstituted or trisubstituted, or a phenyl radical which is unsubstituted or monosubstituted, disubstituted or trisubstituted are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders and for the treatment of tumours.
    Type: Application
    Filed: September 3, 2003
    Publication date: May 13, 2004
    Inventors: Werner Mederski, Horst Juraszyk, Dieter Dorsch, Christos Tsaklakidis, Johannes Gleitz, Christopher Barnes, Bertram Cezanne
  • Treating muscle wasting with selective androgen receptor modulators
    Publication number: 20040087557
    Abstract: This invention provides: 1) a method of treating a subject suffering from a muscle wasting disorder; 2) a method of preventing a muscle wasting disorder in a subject; 3) a method of treating, preventing, suppressing, inhibiting or reducing muscle loss in a subject suffering from a muscle wasting disorder; 4) a method of treating, preventing, inhibiting, reducing or suppressing muscle wasting in a subject suffering from a muscle wasting disorder; and/or 5) a method of treating, preventing, inhibiting, reducing or suppressing muscle protein catabolism in a subject suffering from a muscle wasting disorder, by administering to the subject a selective androgen receptor modulator (SARM) and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide or any combination thereof, as described herein.
    Type: Application
    Filed: December 5, 2002
    Publication date: May 6, 2004
    Inventors: Mitchell S. Steiner, Karen A. Veverka, James T. Dalton, Duane D. Miller
  • Inhibitors of IMPDH enzyme
    Publication number: 20040087650
    Abstract: The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
    Type: Application
    Filed: September 25, 2003
    Publication date: May 6, 2004
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Jeffrey O. Saunders, Daniel Elbaum, Perry M. Novak, Douglas Naegele, Randy S. Bethiel, Steven M. Ronkin, Michael C. Badia, Catharine Frank, Dean P. Stamos, William Walters, David Pearlman
  • Phenyl derivatives
    Publication number: 20040087582
    Abstract: Novel compounds of the formula I in which W, X, Y, T, R1 and R2 are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders.
    Type: Application
    Filed: December 18, 2003
    Publication date: May 6, 2004
    Inventors: Dieter Dorsch, Werner Mederski, Christos Tsaklakidis, Bertram Cezanne, Johannes Gleitz, Christopher Barnes
  • Urea- and urethane-substituted acylureas, process for their preparation and their use
    Publication number: 20040087659
    Abstract: The invention relates to urea- and urethane-substituted acylureas and to their physiologically tolerated salts and physiologically functional derivatives.
    Type: Application
    Filed: July 11, 2003
    Publication date: May 6, 2004
    Inventors: Elisabeth Defossa, Dieter Kadereit, Thomas Klabunde, Hans-Joerg Burger, Andreas Herling, Karl-Ulrich Wendt, Erich Von Roedern, Karl Schoenafinger
  • Electrophilic ketones for the treatment of herpesvirus infections
    Publication number: 20040087491
    Abstract: A class of compounds is described which can be used for the treatment of viral infections.
    Type: Application
    Filed: October 30, 2003
    Publication date: May 6, 2004
    Inventors: Daniel L. Flynn, Kenneth Williams, Susan L. Hockerman, Jeffrey Zablocki
  • Novel florfenicol-type antibiotics
    Publication number: 20040082553
    Abstract: The present invention relates to novel florfenicol compounds having the chemical structure: 1
    Type: Application
    Filed: April 8, 2003
    Publication date: April 29, 2004
    Inventors: Constantine G. Boojamra, Lee S. Chong, Scott J. Hecker, Tomasz W. Glinka, Dale E. Shuster
  • Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use
    Publication number: 20040077716
    Abstract: The invention relates to acyl-4-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives.
    Type: Application
    Filed: April 10, 2003
    Publication date: April 22, 2004
    Inventors: Elisabeth Defossa, Dieter Kadereit, Karl Schoenafinger, Thomas Klabunde, Hans-Joerg Burger, Andreas Herling, Karl-Ulrich Wendt, Erich Von Roedern, Alfons Enhsen, Joerg Rieke-Zapp
  • Malonamic acids and derivatives thereof as thyroid receptor ligands
    Publication number: 20040077694
    Abstract: The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula I, which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias, skin disorders, thyroid disease, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, congestive heart failure, hypercholesteremia, depression, osteoporosis and hair loss. The present invention also provides methods, pharmaceutical compositions and kits for treating such diseases and disorders.
    Type: Application
    Filed: October 10, 2003
    Publication date: April 22, 2004
    Inventors: Yuan-Ching P. Chiang, Gary E. Aspnes, Kimberly G. Estep
  • N-bridged selective androgen receptor modulators and methods of use thereof
    Publication number: 20040067979
    Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Application
    Filed: June 17, 2003
    Publication date: April 8, 2004
    Inventors: James T. Dalton, Duane D. Miller, Craig A. Marhefka, Wenqing Gao
  • Pharmaceutical formulation
    Publication number: 20040067257
    Abstract: The present invention relates to a pharmaceutical formulation comprising bicalutamide and an enteric polymer having a pKa from 3 to 6. The invention also relates to a daily pharmaceutical dose of bicalutamide provided by such a formulation. In addition, the invention relates to the use of such an enteric polymer in solid dispersion with bicalutamide for increasing the bioavailability of the bicalutamide; for reducing inter-patient variability in plasma concentrations of bicalutamide; or for treating and/or reducing the risk of prostate cancer in a patient.
    Type: Application
    Filed: August 18, 2003
    Publication date: April 8, 2004
    Inventors: Nicola Bateman, Jlulie Cahill
  • Bicalutamide forms
    Publication number: 20040063782
    Abstract: A new crystalline form of bicalutamide (form II) is disclosed. Bicalutamide form II is useful as a pharmaceutical and has antiandrogenic activity.
    Type: Application
    Filed: September 12, 2003
    Publication date: April 1, 2004
    Inventor: Raymond J.H. Westheim
  • Compounds active at the glucocorticoid receptor II
    Publication number: 20040063781
    Abstract: 1
    Type: Application
    Filed: October 14, 2003
    Publication date: April 1, 2004
    Inventors: Benjamin Pelcman, Annika Gustafsson, Philip R Kym
  • Controlled release formulation for treating COPD
    Patent number: 6713509
    Abstract: This invention relates to a controlled or sustained release formulation designed to deliver a PDE4 inhibitor for treating an inflammatory disease such as asthma or COPD and the like.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: March 30, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Patrick G. Faulkner, Jaime J. Lucca, Thomas J. Wrzosek
  • Compounds
    Publication number: 20040058916
    Abstract: A compound having general formula 1
    Type: Application
    Filed: June 11, 2003
    Publication date: March 25, 2004
    Inventor: Ashokkumar Bhikkappa Shenvi
  • Use of phenethyl acrylamides, novel phenethyl acrylamides, method for the production thereof and agents containing the same
    Patent number: 6696607
    Abstract: Use of phenethylacrylamides of the formula I: in which the substituents have the following meanings: X is halogen, alkyl, haloalkyl, alkoxy, haloalkoxy and —O—C(Ra,Rb)—C≡C—R6; Ra,Rb and Rc have the meanings given in the description; m,n independently of one another are 1 to 4, it being possible for the radicals X or Y to be different if m or n is greater than 1; Y is halogen, nitro, cyano, alkyl, CF3, alkoxy and phenyl; R1,R2 independently of one another are hydrogen, halogen, alkyl, alkoxy, haloalkoxy and CF3; R3,R4,R5,R6 independently of one another are hydrogen, halogen, alkyl, alkoxy, or R3 and R4 together form a cyclopropyl ring, it being possible for the C—R5— and C—R6 bonds can be in the E- or Z-position relative to each other; for controlling phytopathogenic fungal pests, novel phenethylacrylamides, their preparation, and compositions comprising them.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: February 24, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Wassilios Grammenos, Hubert Sauter, Oliver Cullmann, Markus Gewehr, Bernd Müller, Jordi Tormo i Blasco, Norbert Götz, Thorsten Volk, Gisela Lorenz, Eberhard Ammermann, Reinhard Stierl, Siegfried Strathmann
  • Halogenated selective androgen receptor modulators and methods of use thereof
    Publication number: 20040029913
    Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Application
    Filed: February 24, 2003
    Publication date: February 12, 2004
    Inventors: James T. Dalton, Duane D. Miller, Mitchell S. Steiner, Karen A. Veverka
  • Novel n-( 2-phenyl-3-aminopropyl)naphtamides
    Publication number: 20040014809
    Abstract: A compound of the formula 1
    Type: Application
    Filed: January 21, 2003
    Publication date: January 22, 2004
    Inventor: Peter Bernstein
  • Process for preparing aminoguanidines and alkoxyguanidines as protease inhibitors
    Publication number: 20040002539
    Abstract: Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: 1
    Type: Application
    Filed: April 22, 2003
    Publication date: January 1, 2004
    Applicant: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Bruce E. Tomczuk, Richard M. Soll, Tianbao Lu, Cynthia L. Fedde, Carl R. Illig, Thomas P. Markotan
  • Cyclopropanecarboxylic acid amide compound and pharmaceutical use thereof
    Publication number: 20040002521
    Abstract: The present invention provides an NF-kappa B activation inhibitor, an inflammatory cytokine production inhibitor, a matrix metalloprotease production inhibitor, an inflammatory cell adhesion factor expression inhibitor, and an anti-inflammatory agent, an antirheumatic agent, an immuno-suppressive agent, an antiallergic agent, an antiviral agent, or a therapeutic agent for arteriosclerosis, which comprise, as the active ingredient, a cyclopropanecarboxylic acid amide compound or a pharmaceutically acceptable salt thereof effective for the treatment of inflammatory diseases.
    Type: Application
    Filed: April 30, 2003
    Publication date: January 1, 2004
    Applicant: AJINOMOTO CO. INC
    Inventors: Yukio Iino, Takashi Yamamoto, Tsuyoshi Kobayashi