C(=o)n Containing Patents (Class 514/528)
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Publication number: 20020128311Abstract: A stabilized halocyanoacetamide composition in the form of a solution or emulsifiable concentrate using selected ester solvents is disclosed. Preferred ester solvents include glyceryl triacetate, ethyl acetate and diethyl phthalate. Particularly preferred are stabilized compositions containing 2,2-dibromo-3-nitrilopropionamide, glyceryl triacetate and optional non-ionic surfactants or additional antimicrobial compounds, particularly 3-isothiazolone compounds.Type: ApplicationFiled: December 12, 2001Publication date: September 12, 2002Inventors: Kevin F. Gironda, John Robert Mattox, Richard W. Nichols, Andre Elvis Pressley, George Harvey Redlich, Bing Yu
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Patent number: 6441028Abstract: A phytomicrobicidal composition comprising such an amount of at least two active ingredient components that a synergistic effect is achieved, together with a suitable carrier material, wherein component I is a compound of the formula I in which: X is CH or N; R is CH3 or cyclopropyl; Y is H, F, Cl, Br, CF3, CF3O, propargyloxy; Z is H, F, Cl, CF3, CF3O; or Y and Z together are a methylenedioxy, a (difluoromethylene)dioxy, an ethylenedioxy, a (trifluoroethylene)dioxy or a benzo group; and wherein component II is a compound selected from the group consisting of II A) metalaxyl, II B) R-metalaxyl, II C) furalaxyl, II D) benalaxyl, II E) ofurace, II F) oxadixyl, II G) cymoxanil and II H) mancozeb.Type: GrantFiled: August 13, 2001Date of Patent: August 27, 2002Assignee: Bayer AktiengesellschaftInventors: Gertrude Knauf-Beiter, Ronald Zeun
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Patent number: 6436934Abstract: Fungicidal mixtures comprise as active components a) an amide compound of the formula I A—CO—NR1R2 I in which A, R1 and R2 are as defined in the description, and b) dimethomorph or flumetover, and/or c) a valinamide of the formula III in which R13 is C3-C4-alkyl and R14 is naphthyl or phenyl, where the phenyl radical is substituted in the 4-position by a halogen atom, a C1-C4-alkyl or C1-C4-alkoxy group, and/or d) benalaxyl, ofurace, metalaxyl, furalaxyl or oxydixyl, and/or e) 1-(2-cyano-2-methoxyiminoacetyl)-3-ethylurea in a synergistically effective amount.Type: GrantFiled: June 19, 2000Date of Patent: August 20, 2002Assignee: BASF AktiengesellschaftInventors: Klaus Schelberger, Maria Scherer, Karl Eicken, Manfred Hampel, Eberhard Ammermann, Gisela Lorenz, Siegfreid Strathmann
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Publication number: 20020107286Abstract: When used in admixture with mancozeb, chlorothalonil, a copper salt, folpet, fluazinam or cymoxanil (it being possible for the latter to be used also together with one of the other five components), metalaxyl having a high R-enantiomer content of more than 70% by weight, or pure R-metalaxyl, exhibits a markedly increased fungicidal action against plant diseases as compared with a similar mixture in which metalaxyl is used in the form of the racemate.Type: ApplicationFiled: January 23, 2002Publication date: August 8, 2002Inventors: Cosima Nuninger, John Edward Nicholas Goggin, Dino Sozzi
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Patent number: 6369104Abstract: A microbial inhibiting composition and method are disclosed. The composition comprises an amount, effective for the intended purpose, of glutaraldehyde and 2,2-dibromo-3-nitrilopropionamide. The method comprises administering between about 0.1 and 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.Type: GrantFiled: July 17, 2000Date of Patent: April 9, 2002Assignee: Hercules IncorporatedInventors: Lynn G. Kleina, Wilson K. Whitekettle
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Patent number: 6369105Abstract: When used in admixture with mancozeb, chlorothalonil, a copper salt, folpet, fluazinam or cymoxanil (it being possible for the latter to be used also together with one of the other five components), metalaxyl having a high R-enantiomer content of more than 70% by weight, or pure R-metalaxyl, exhibits a markedly increased fungicidal action against plant diseases as compared with a similar mixture in which metalaxyl is used in the form of the racemate.Type: GrantFiled: August 29, 2000Date of Patent: April 9, 2002Assignee: Syngenta Investment CorporationInventors: Cosima Nuninger, John Edward Nicholas Goggin, Dino Sozzi
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Patent number: 6329424Abstract: A phytomicrobicidal composition comprising such an amount of at least two active ingredient components that a synergistic effect is achieved, together with a suitable carrier material, wherein component I is a compound of the formula I in which: X is CH or N; R is CH3 or cyclopropyl; Y is H, F, Cl, Br, CF3, CF3O, propargyloxy; Z is H, F, Cl, CF3, CF3O; or Y and Z together are a methylenedioxy, a (difluoromethylene)dioxy, an ethylenedioxy, a (trifluoroethylene)dioxy or a benzo group; and wherein component II is a compound selected from the group consisting of II A) metalaxyl, II B) R-metalaxyl, II C) furalaxyl, II D) benalaxyl, II E) ofurace, II F) oxadixyl, II G) cymoxanil and II H) mancozeb.Type: GrantFiled: October 29, 1999Date of Patent: December 11, 2001Assignee: Bayer AktiengesellschaftInventors: Gertrude Knauf-Beiter, Ronald Zeun
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Patent number: 6248762Abstract: When used in admixture with mancozeb, chlorothalonil, a copper salt, folpet, fluazinam or cymoxanil (it being possible for the latter to be used also together with one of the other five components), metalaxyl having a high R-enantiomer content of more than 70% by weight, or pure R-metalaxyl, exhibits a markedly increased fungicidal action against plant diseases as compared with a similar mixture in which metalaxyl is used in the form of the racemate.Type: GrantFiled: May 17, 2000Date of Patent: June 19, 2001Assignee: Syngenta Investment CorporationInventors: Cosima Nuninger, John Edward Nicholas Goggin, Dino Sozzi
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Patent number: 6239158Abstract: A composition comprising effective amounts of a) a carbamate of the formula I where T is CH or N, n is 0, 1 or 2, and R is halogen, C1-C4-alkyl or C1-C4-haloalkyl, where the radicals R are identical or different if n is 2, and b) 1-(2-cyano-2-methoxyiminoacetyl)-3-ethylurea (III) H3CCH2—NHCONH—CO—C(CN)═NOCH3 (III) which exhibits a synergistically enhanced fungicidal effect is described.Type: GrantFiled: October 31, 2000Date of Patent: May 29, 2001Assignee: BASF AktiengesellschaftInventors: Bernd Müller, Hubert Sauter, Eberhard Ammermann, Gisela Lorenz, Siegfried Strathmann, Maria Scherer, Klaus Schelberger, Joachim Leyendecker
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Patent number: 6228883Abstract: A method for combatting plant fungi in a plant, which comprises applying to the seeds or tubers of the plant, an effective amount of a fungicidal composition comprising a fungicidally effective amount of a 2-alkoxyiminoacetamide compound, optionally in admixture with one or both of an alkylene bis-dithiocarbamate complex salt and a thiophanate compound. Fungicidal compositions comprising a fungicidally effective amount of a 2-alkoxyiminoacetamide compound, an alkylene bis-dithiocarbamate complex salt, and a thiophanate compound, are also described.Type: GrantFiled: August 12, 1998Date of Patent: May 8, 2001Assignee: Gustafson, Inc.Inventor: Jennifer Lynn Riggs
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Patent number: 6172094Abstract: A composition comprising effective amounts of a) a carbamate of the formula I where X is CH or N, n is 0, 1 or 2 and R is halogen, C1-C4-alkyl or C1-C4-haloalkyl, it being possible for the radicals R to be different if n is 2, and b) a dithiocarbamate (II) selected from the group consisting of manganese ethylenebis(dithiocarbamate) (zinc complex) (IIa), manganese ethylenebis(dithiocarbamate) (IIb), zinc ammoniate ethylenebis(dithiocarbamate) (IIc) and zinc ethylenebis(dithiocarbamate) (IId) and optionally c) 1-(2-cyano-2-methoxyiminoacetyl)-3-ethylurea (III) H3CCH2—NHCONH—CO—C(CN)═NOCH3 (III) which exhibits a synergistically enhanced fungicidal effect is described.Type: GrantFiled: October 22, 1998Date of Patent: January 9, 2001Assignee: BASF AktiengesellschaftInventors: Bernd M{umlaut over (u)}ller, Hubert Sauter, Eberhard Ammermann, Gisela Lorenz, Siegfried Strathmann, Maria Scherer, Klaus Schelberger, Joachim Leyendecker
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Patent number: 6127411Abstract: A method for combatting plant fungi in a plant, which comprises applying to the seeds or tubers of the plant, an effective amount of a fungicidal composition comprising a fungicidally effective amount of a 2-alkoxyiminoacetamide compound, optionally in admixture with one or both of an alkylene bis-dithiocarbamate complex salt and a thiophanate compound. Fungicidal compositions comprising a fungicidally effective amount of a 2-alkoxyimino-acetamide compound, an alkylene bis-dithiocarbamate complex salt, and a thiophanate compound, are also described.Type: GrantFiled: June 25, 1999Date of Patent: October 3, 2000Assignee: Gustafson, Inc.Inventor: Jennifer Lynn Riggs
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Patent number: 6114382Abstract: The present invention provides novel compositions and methods relating to the treatment of Inflammatory Bowel Disease ("IBD"), most notably, Ulcerative Colitis, Crohn's Disease, Colitis and Diverticulitis. The invention relates to the discovery of a parasitic microsporidia infecting the epithelium cells lining the gastrointestinal tract of patients suffering from IBD. The discovery of this correlation between the disease and the microsporidia, described herein, led to the development of methods for the accurate diagnosis of patients suffering from IBD, and also of methods for treating such a patient in accordance with the invention. This discovery also provides for the development of animal models to further elucidate the mechanism of the disease and potential additional cures therefor.Type: GrantFiled: November 11, 1998Date of Patent: September 5, 2000Inventor: Itagiba G. Moretti
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Patent number: 6103768Abstract: The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination treatments whereby fatty acids are used to enhance or augment the activity of fungicides, bactericides, and biological control agents.Type: GrantFiled: September 8, 1997Date of Patent: August 15, 2000Assignee: Mycogen CorporationInventors: Steven D. Savage, Steven L. Evans, Robert A. Haygood, Paul S. Zorner, Keith Jones
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Patent number: 6075042Abstract: A fungicidal composition comprising a compound A having the formula: ##STR1## wherein M is an oxygen or sulphur atom, n is 0 or 1, and Y is a fluorine or chlorine atom or a methyl radical; and at least one fungicidal compound B. A method for preventing or controlling phytopathogenic fungi on crops by applying an effective and non-plant-poisonous amount of said compound on the exposed parts of the plants is also disclosed.Type: GrantFiled: January 12, 1999Date of Patent: June 13, 2000Assignee: Rhone Poulenc AgrochimieInventor: Marie-Pascale Latorse
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Patent number: 6007819Abstract: The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.Type: GrantFiled: October 17, 1996Date of Patent: December 28, 1999Assignee: Dovetail Technologies, Inc.Inventors: Floyd Taub, Thomas J. Perun, Christopher K. Murray, Randall J. Daughenbaugh, Daniel Lednicer
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Patent number: 5977180Abstract: Anandamide analogues useful for the treatment of intraocular hypertension, as well as ophthalmic compositions comprising the same and a cyclodextrin, and methods of use of these compounds to treat intraocular hypertension.Type: GrantFiled: January 10, 1997Date of Patent: November 2, 1999Inventors: David W. Pate, Tomi Jarvinen, Kristina Jarvinen, Arto Urtti
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Patent number: 5973001Abstract: Fungicidal mixture, comprisinga) an oxime ether carboxamide of the formula I ##STR1## where R is hydrogen or halogen and b) 1-(2-cyano-2-methoxyiminoacetyl)-3-ethylurea (II)H.sub.3 CCH.sub.2 --NHCONH--C (CN).dbd.NOCH.sub.3 IIin a synergistically active amount.Type: GrantFiled: February 22, 1998Date of Patent: October 26, 1999Assignee: BASF AktiengesellshcaftInventors: Barbara Schwalge, Ruth Muller, Herbert Bayer, Hubert Sauter, Eberhard Ammermann, Gisela Lorenz, Siegfried Strathmann
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Patent number: 5948805Abstract: Advantageous combinations of an oxazolidinone and cymoxanil (or their agriculturally suitable salts) and their use to control fungus disease in plants are disclosed, the oxazolidinone having the formula ##STR1##Type: GrantFiled: January 9, 1998Date of Patent: September 7, 1999Assignee: E. I. du Pont de Nemours and CompanyInventors: Ray M. Geddens, Marsha J. Martin
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Patent number: 5945091Abstract: A method of using compounds of formula I ##STR1## in which the C.dbd.C double bond is present in E and/or Z configuration and the variables have the following meanings:R.sup.1 denotes COOR.sup.5, COR.sup.5, CONR.sup.5 R.sup.6, CN, O.dbd.S(--R.sup.5).dbd.O, O.dbd.S(--OR.sup.5).dbd.O, R.sup.7 O--P(--OR.sup.8).dbd.O;R.sup.2 denotes COOR.sup.6, COR.sup.6, CONR.sup.5 R.sup.6, CN, O.dbd.S(--R.sup.6).dbd.O, O.dbd.S(--OR.sup.6).dbd.O, R.sup.7 O--P(--OR.sup.8).dbd.O;R.sup.3 denotes hydrogen, an optionally substituted aliphatic, cycloaliphatic, araliphatic or aromatic radical having in each case up to 18 carbon atoms;R.sup.4 denotes an optionally substituted aromatic or heteroaromatic radical containing from 5 to 12 ring atoms;R.sup.5 toR.sup.8 independently denote hydrogen, an open-chain or branched-chain aliphatic, araliphatic, cycloaliphatic or optionally substituted aromatic radical containing in each case up to 18 carbon atoms,where the variables R.sup.3 to R.sup.Type: GrantFiled: November 18, 1997Date of Patent: August 31, 1999Assignee: BASF AktiengesellschaftInventors: Thorsten Habeck, Alexander Aumuller, Volker Schehlmann, Horst Westenfelder, Thomas Wunsch
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Patent number: 5891908Abstract: Fungicidal mixtures comprisinga) the oxime ether carboxylic ester of the formula I ##STR1## and b) 1-(2-cyano-2-methoxyiminoacetyl)-3-ethylurea (II)H.sub.3 CCH.sub.2 --NHCONH--C (CN).dbd.NOCH.sub.3 IIin a synergistically effective amount.Type: GrantFiled: December 10, 1996Date of Patent: April 6, 1999Assignee: BASF AktiengesellschaftInventors: Eberhard Ammermann, Gisela Lorenz, Dietrich Mappes, Klaus Schelberger, Manfred Hampel
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Patent number: 5874459Abstract: Disclosed is a method of inhibiting anandamide amidase in an individual or animal and novel inhibitors of anandamide amidase. The disclosed method and novel compounds can be used to reduce pain in an individual or animal suffering from pain, reducing nausea in an individual undergoing chemotherapy, for example cancer chemotherapy, suppressing appetite in an individual, reducing intraocular pressure in the eye of an individual or animal suffering from glaucoma and suppressing the immune system in an individual with an organ transplant.Type: GrantFiled: November 12, 1997Date of Patent: February 23, 1999Assignee: University of ConnecticutInventors: Alexandros Makriyannis, Sonyan Lin, William Adam Hill
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Patent number: 5780450Abstract: Compositions and methods directed to the use of adenosine uptake inhibitors for the treatment of retinal and optic nerve head damage following acute or chronic glaucoma, edema, ischemia, hypoxia or trauma are disclosed.Type: GrantFiled: November 21, 1995Date of Patent: July 14, 1998Assignee: Alcon Laboratories, Inc.Inventor: Debra L. Shade
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Patent number: 5716608Abstract: Disclosed are methods for inhibiting acute radiation-induced skin damage during treatment of a patient with ionizing radiation by application of a layer of biocompatible polymer to the skin surface prior to exposure of the surface to ionizing radiation.Type: GrantFiled: May 6, 1996Date of Patent: February 10, 1998Assignee: MedLogic Global CorporationInventors: Michael M. Byram, Robert Goebel, Richard J. Greff, Leonard V. Barley, Jr.
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Patent number: 5716607Abstract: Disclosed are methods for inhibiting late radiation-induced skin damage during treatment of a patient with ionizing radiation by application of a layer of biocompatible polymer to the skin surface prior to exposure of the surface to ionizing radiation.Type: GrantFiled: May 6, 1996Date of Patent: February 10, 1998Assignee: MedLogic Global CorporationInventors: Michael M. Byram, Robert Goebel, Richard J. Greff, Leonard V. Barley, Jr.
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Patent number: 5633254Abstract: Synergistic mixtures which include dimethomorph and cymoxonil in a fungicidially effective aggregate amount, and the use of such mixtures in the control of plant diseases. In certain embodiments, a contact fungicide is included, along with the dimethomorph and cymoxonil in suitable ratios.Type: GrantFiled: January 11, 1996Date of Patent: May 27, 1997Assignees: Agrogene Ltd., C.T.S. Ltd.Inventor: Yigal Cohen
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Patent number: 5631297Abstract: Anandamides useful for the treatment of intraocular hypertension, as well as ophthalmic compositions comprising the same and a cyclodextrin, and methods of use of these compounds to treat intraocular hypertension.Type: GrantFiled: July 11, 1994Date of Patent: May 20, 1997Inventors: David W. Pate, Tomi Jarvinen, Kristiina Jarvinen, Arto Urtti
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Patent number: 5627135Abstract: Stable, concentrated aqueous suspensions of 2,2-dibromo-3-nitrilopropionamide which contribute minimal chemical oxygen demand to systems treated therewith and methods of preparing and using said suspensions in biocidal applications have been discovered. The formulations comprise from about 3 to about 70 weight percent 2,2-dibromo-3-nitrilopropionamide suspended in about 30 to about 97 weight percent water in the presence of a suspending amount of a thixotrope that exhibits Ellis-Plastic behavior, such as xantham gum and locust bean gum, at a pH of from about 1 to about 4.Type: GrantFiled: March 20, 1996Date of Patent: May 6, 1997Assignee: The Dow Chemical CompanyInventor: Charles D. Gartner
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Patent number: 5554365Abstract: Disclosed are methods for inhibiting acute and/or late radiation/induced skin damage during treatment of a patient with ionizing radiation by application of a layer of cyanoacrylate adhesive to the skin surface prior to exposure of the surface to ionizing radiation.Type: GrantFiled: May 5, 1995Date of Patent: September 10, 1996Assignee: MedLogic Global CorporationInventors: Michael M. Byram, Robert Goebel, Richard J. Greff, Leonard V. Barley, Jr.
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Patent number: 5457127Abstract: A fungicidal mixture containinga) the oxime ether carboxamide of the formula I ##STR1## and b) 1-(2-cyano-2-methoxyiminoacetyl)-3-ethylurea (II)H.sub.3 CCH.sub.2 -NHCONHCO-C(CN).dbd.NOCH.sub.3in a synergistically active amount is described.Type: GrantFiled: September 23, 1994Date of Patent: October 10, 1995Assignee: BASF AktiengesellschaftInventors: Horst Wingert, Hubert Sauter, Eberhard Ammermann, Gisela Lorenz, Reinhold Saur, Klaus Schelberger, Manfred Hampel
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Patent number: 5326784Abstract: New cycloalkylalkylamines which are sigma-receptor ligands of formule (I) ##STR1## in which: R.sub.1 is H or lower alkyl; X and Y are H, OH, lower alkyl, lower alkoxy, halogen or nitrile; V.sub.1 and V.sub.2 together form a double bond attached to an oxygen atom or to a hydroxyimino radical, or are linked as an ethylenedioxy chain; A represents a valency bond, an oxygen atom, a methylene or an ethylene group; m is equal to 0, 1 or 2; n has the value of an integer from 1 to 5. Psychotropic drug which is also useful in gastroenterology.Type: GrantFiled: July 29, 1993Date of Patent: July 5, 1994Assignee: Institut de Recherche JouveinalInventors: Jean-Louis Junien, Alain Calvet, Henri Jacobelli, Francois Roman
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Patent number: 5278187Abstract: Compounds of formula (II) ##STR1## wherein R.sub.1 and R.sub.2 are each separately selected from hydrogen, alkyl, alkenyl and alkynyl groups having up to a maximum of four carbon atoms and being unsubstituted, and alkyl, alkenyl and alkynyl groups having up to a maximum of three carbon atoms and being substituted by one, or in the case of fluoro by one or more, substituents but with the proviso that when R.sub.1 is hydrogen then R.sub.2 is hydrogen or methyl, or R.sub.1 and R.sub.2 together constitute an ethylene bridging group, and R.sub.3 is a group which under physiological conditions undergoes elimination with the formation of a 3,5-dioxopiperazinyl ring, with the further proviso that the compound is in the meso or erythro configuration when each of R.sub.1 and R.sub.2 is the same or different unsubstituted or substituted alkyl, alkenyl or alkynyl group, and salts thereof with a physiologically acceptable inorganic or organic acid, are of value as prodrugs, particularly for effecting cardioprotection.Type: GrantFiled: September 24, 1991Date of Patent: January 11, 1994Assignee: British Technology Group Ltd.Inventors: Andrew M. Creighton, William A. Jeffery
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Patent number: 5273987Abstract: Synergistic microbicidal compositions are disclosed, comprising 4,5-dichloro-2-cyclohexyl-3-isothiazolone and one or more known microbicides for more effective, and broader control of microorganisms in various systems.Type: GrantFiled: April 22, 1993Date of Patent: December 28, 1993Assignee: Rohm and Haas CompanyInventor: Jemin C. Hsu
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Patent number: 5189061Abstract: Novel fungicidally active compounds of the formula ##STR1## in which R represents alkyl, cyanoalkyl or in each case optionally substituted alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl or phenylalkyl,R.sup.1 represents the --OR.sup.2 or --NR.sup.3 R.sup.4 groups, andR.sup.3 and R.sup.4 have special special definitions.Type: GrantFiled: February 22, 1991Date of Patent: February 23, 1993Assignee: Bayer AktiengesellschaftInventors: Winfried Lunkenheimer, Wilhelm Brandes, Gerd Hanssler
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Patent number: 5169866Abstract: Seed potatoes are fogged with a composition comprising 2,2-dibromo-3-nitrilopropionamide. Control of pathogens on potatoes is obtained with relatively low amounts of active material.Type: GrantFiled: June 11, 1991Date of Patent: December 8, 1992Assignee: Bromine Compounds LimitedInventor: Ayala Barak
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Patent number: 5166212Abstract: Disclosed are compound of the formula ##STR1## wherein X and Y independently represent hydroxymethyl; cyano; carboxy; functionally modified carboxy selected from esterified carboxy, carbamoyl, and N-substituted carbamoyl; 5-tetrazolyl; 2-oxazolyl, 4,5-dihydro-2-oxazolyl, or each said grouping substituted by lower alkyl; R and R.sub.o independently represent lower alkyl, (C.sub.3 -C.sub.7)-cycloalkyl-lower alkyl, or aryl-lower alkyl; A represents methylene; or A represents methylene substituted by lower alkyl, by lower alkylthio-lower alkyl, by aryl-lower alkylthio-lower alkyl, by arylthio-lower alkyl, by hydroxy-lower alkyl, by acyloxy-lower alkyl, by lower alkoxy-lower alkyl, by alkyloxy-lower alkyl, by aryloxy-lower alkyl, by amino-lower alkyl by acylamino-lower alkyl, by guanidino-lower amino-lower alkyl, by (C.sub.3 -C.sub.7)-cycloalkyl, by (C.sub.3 -C.sub.Type: GrantFiled: April 25, 1991Date of Patent: November 24, 1992Assignee: Ciba-Geigy CorporationInventor: Gary M. Ksander
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Patent number: 5162372Abstract: Compounds of formula (II) ##STR1## wherein R.sub.1 and R.sub.2 are each separately selected from hydrogen, alkyl, alkenyl and alkynyl groups having up to a maximum of four carbon atoms and being unsubstituted, and alkyl, alkenyl and alkynyl groups having up to a maximum of three carbon atoms and being substituted by one, or in the case of fluoro by one or more, substituents but with the proviso that when R.sub.1 is hydrogen then R.sub.2 is hydrogen or methyl, or R.sub.1 and R.sub.2 together constitute an ethylene bridging group, and R.sub.3 is a group which under physiological conditions undergoes elimination with the formation of a 3,5-dioxopiperazinyl ring, with the further proviso that the compound is in the meso or erythro configuration when each of R.sub.1 and R.sub.Type: GrantFiled: March 25, 1991Date of Patent: November 10, 1992Assignee: National Research Development CorporationInventors: Andrew M. Creighton, William A. Jeffery
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Patent number: 5149710Abstract: Compounds of formula (II) ##STR1## wherein R.sub.1 and R.sub.2 are each separately selected from hydrogen, alkyl, alkenyl and alkynyl groups having up to a maximum of four carbon atoms and being unsubstituted, and alkyl, alkenyl and alkynyl groups having up to a maximum of three carbon atoms and being substituted by one, or in the case of fluoro by one or more, substituents but with the proviso that when R.sub.1 is hydrogen then R.sub.2 is hydrogen or methyl, or R.sub.1 and R.sub.2 together constitute an ethylene bridging group, and R.sub.3 is a group which under physiological conditions undergoes elimination with the formation of a 3,5-dioxopiperazinyl ring, with the further proviso that the compound is in the meso or erythro configuration when each of R.sub.1 and R.sub.2 is the same or different unsubstituted or substituted alkyl, alkenyl or alkynyl group, and salts thereof with a physiologically acceptable inorganic or organic acid, are of value as prodrugs, particularly in the therapy of psoriasis.Type: GrantFiled: October 17, 1990Date of Patent: September 22, 1992Assignee: National Research Development CorporationInventors: Andrew M. Creighton, William A. Jeffery
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Patent number: 5134160Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose of 3-iodo-2-propynyl-butyl carbamate and 2,2-dibromo-2-nitrilopropionamide. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.Type: GrantFiled: October 15, 1991Date of Patent: July 28, 1992Assignee: Betz Laboratories, Inc.Inventors: Wilson K. Whitekettle, Deborah K. Donofrio
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Patent number: 4945111Abstract: Fungicidal N,N'-diacylaminals of the formula ##STR1## in which R.sup.1 is optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl or cycloalkenyl,R.sup.2 and R.sup.3 are hydrogen or various organic radicals, andX is oxygen or sulphur.Type: GrantFiled: August 11, 1988Date of Patent: July 31, 1990Assignee: Bayer AktiengesellschaftInventors: Winfried Lunkenheimer, Dieter Berg, Wilhelm Brandes
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Patent number: 4916159Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose, of 2-(decylthio)ethanamine hydrochloride and 2,2-dibromo-3-nitrilo propionamide. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.Type: GrantFiled: May 25, 1989Date of Patent: April 10, 1990Assignee: Betz Laboratories, Inc.Inventors: Wilson K. Whitekettle, Deborah K. Donofrio
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Patent number: 4916130Abstract: An antithrombotic composition containing an amide derivative which is obtained by binding a sulfur-containing amine to an unsaturated fatty acid having 4 to 13 carbon atoms through an amide bond and which exerts a high platelet agglutination-inhibiting effect.Type: GrantFiled: September 8, 1988Date of Patent: April 10, 1990Assignee: Green Cross CorporationInventors: Masakazu Iwai, Chikara Fukaya, Kazumasa Yokoyama
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Patent number: 4902714Abstract: Compounds of the formula (II) ##STR1## wherein R.sub.1 and R.sub.2 are each separately selected from hydrogen, alkyl, alkenyl and alkynyl groups having up to a maximum of four carbon atoms and being unsubstituted, and alkyl, alkenyl and alkynyl groups having up to a maximum of three carbon atoms and being substituted by one, or in the case of fluoro by one or more, substitutents but with the proviso that when R.sub.1 is hydrogen then R.sub.2 is hydrogen or methyl, or R.sub.1 and R.sub.2 together constitute an ethylene bridging group, and R.sub.3 is a group which under physiological conditions undergoes elimination with the formation of a 3,5-dioxopiperazinyl ring, with the further proviso that the compound is in the meso or erythro configuration when each of R.sub.1 and R.sub.Type: GrantFiled: April 19, 1988Date of Patent: February 20, 1990Assignee: National Research Development CorporationInventors: Andrew M. Creighton, William A. Jeffery
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Patent number: 4886833Abstract: Novel fungicides of the formula ##STR1## in which R.sup.1 represents optionally substituted hydroxyalkyl, optionally substituted hydroxyalkoxyalkyl, optionally substituted heteroarylalkyl or optionally substituted heteroaryl, andR.sup.2 represents optionally substituted alkyl, optionally substituted alkenyl, or alkinyl.Intermediate therefor, wherein R.sup.2 is hydrogen or an alkali metal cation, are also new.Type: GrantFiled: August 24, 1987Date of Patent: December 12, 1989Assignee: Bayer AktiengesellschaftInventors: Herbert Gayer, Klaus Jelich, Winfried Lunkenheimer, Wilhelm Brandes, Gerd Hanssler
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Patent number: 4879306Abstract: A composition killing or inhibiting the growth of microorganisms is described and which contains a mixture of 4,5-dichloro-1,2-dithiol-3-one and dibromonitrilopropionamide. The combination leads to a marked synergistic action of the two active substance components in the control of microorganisms. The composition is suitable for use in a large number of industrial systems.Type: GrantFiled: September 27, 1985Date of Patent: November 7, 1989Assignee: Grace Service Chemicals GmbHInventors: Wolf-Dieter Henkels, Marion Balzer
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Patent number: 4874786Abstract: A method of fighting fungus infections by using compounds having the formula: ##STR1## wherein: R is H, a C.sub.1 -C.sub.4 alkyl, an alkenyl, or an alkynyl radical; n is 1 or 2;A represents a C.sub.1 -C.sub.6 alkylene bridge, an arylene or a heterocyclic bridge;X represents O, S, SO, SO.sub.2 ; andR.sup.1 is selected from the group consisting of C.sub.1 -C.sub.6 alkyl radicals, a phenyl radical, optionally substituted, polyfluoroalkyl radicals containing from 1 to 4 carbon atoms and at least 2 fluorine atoms, polyfluoroalkenyl radicals containing from 2 to 4 carbon atoms and at least 2 fluorine atoms, but excluding compounds having the formula (I) wherein A is an alkylene radical, n is 2, and R.sup.1 is a C.sub.1 -C.sub.6 alkyl radical.Type: GrantFiled: April 9, 1987Date of Patent: October 17, 1989Assignee: Montedison S.p.A.Inventors: Augusto Menconi, Giovanni Camaggi, Franco Gozzo, Luigi Mirenna, Carlo Garavaglia
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Patent number: 4866094Abstract: A method for treating crops against fungal and bacterial infections by fumigation with 2,2-dibromo-3-nitrilopropionamide (DBNPA) is described. The method is particularly useful in potato crops. Fumigant compositions comprising DBNPA which are useful in the invention are also disclosed.Type: GrantFiled: April 12, 1988Date of Patent: September 12, 1989Assignee: Bromine Compounds LimitedInventor: Ayala Barak
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Patent number: 4785019Abstract: N-cyanoalkyl-N-haloalkylthio alkyl-, aryl- and aralkyl-carboxamides of the general formula: ##STR1## wherein R is alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, lower alkenyl of 2 to 6 carbon atoms or lower alkynyl of 2 to 6 carbon atoms, all optionally substituted with 1 to 4 halogen atoms; lower alkoxyalkylene; aryl of 6 to 12 carbon atoms; aralkyl of 7 to 16 carbon atoms; or substituted aryl or substituted aralkyl both substituted with 1 to 3 substituents independently selected from phenyl, lower alkyl of 1 to 6 carbon atoms, lower alkoxy of 1 to 6 carbon atoms, lower alkylthio of 1 to 6 carbon atoms, halogen, nitro, cyano, ##STR2## wherein R.sup.4 is hydrogen or lower alkyl of 1 to 6 carbon atoms, ##STR3## wherein R.sup.5 and R.sup.6 are independently hydrogen or lower alkyl of 1 to 6 carbon atoms; R.sup.1 and R.sup.2 are independently hydrogen, or lower alkyl of 1 to 6 carbon atoms; and R.sup.Type: GrantFiled: February 27, 1986Date of Patent: November 15, 1988Assignee: Chevron Research CompanyInventor: Joseph E. Moore
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Patent number: 4782086Abstract: Fungicidally active novel E-isomers of N.sup..alpha. -(2-cyano-2-alkoximino-acetyl)-amino acid derivatives and peptides of the general formula (I) ##STR1## in which R represents alkyl, alkenyl, alkinyl, cyanoalkyl, azolylalkyl or optionally substituted phenylalkyl, or represents optionally substituted cycloalkyl;R.sup.1 represents hydrogen, alkyl, optionally substituted phenyl or optionally substituted benzyl, or represents alkoxycarbonylamino;R.sup.2 represents hydrogen or alkyl;R.sup.3 represents hydrogen, alkyl, alkoxycarbonylalkyl, hydroxycarbonylalkyl, aminocarbonylalkyl, azolylalkyl, cyanoalkyl, hydroxyalkyl, alkenyl, alkinyl or optionally substituted cycloalkyl, or represents optionally substituted phenyl or phenylalkyl, or represents the groupingR.sup.4 --SO.sub.n --Z--R.sup.4 n and Z having various meanings, andX is --OH--OR.sup.1 or --NR.sup.2 R.sup.3.Type: GrantFiled: February 20, 1987Date of Patent: November 1, 1988Assignee: Bayer AktiengesellschaftInventors: Winfried Lunkenheimer, Hans Scheinpflug, Wilhelm Brandes
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Patent number: 4761427Abstract: Aqueous antimicrobial compositions in which dibromonitrilopropionamide is the active ingredient contain from 1% to the solubility limit of dibromonitrilopropionamide, from 5% to the solubility limit of water and a balance of up to 100% of a propylene glycol (all percentages being by weight). Tests on stability carried out on the aqueous antimicrobial compositions show that the rates of decomposition are completely satisfactory compared with the rates of decomposition of known compositions.Type: GrantFiled: December 6, 1985Date of Patent: August 2, 1988Assignee: Bromine Compounds Ltd.Inventors: Jeane Segall, Leonard M. Shorr