Phosphorus Containing (e.g., Vitamin B12, Etc.) Patents (Class 514/52)
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Patent number: 8049040Abstract: Fluorophosphate containing an ethylene-tetrafluoroethylene moiety of formula (I) or (II): (A)w-P(O)(O?M+)3-w??(I) or wherein A is Rf—(CH2)k—[(CF2CF2)y—(CH2CH2)z]mO and contains from about 8 to about 22 carbon atoms; Rf is CnF2n+1; n and k are each independently 1 to about 6; y, z, and m are each independently 1, 2, 3, or mixture thereof; w is 1 or 2 or a mixture thereof; and M is hydrogen, ammonium ion, an alkali metal ion, or an alkanolammonium ion, said fluorophosphate useful as a surfactant for altering the surface behavior of a liquid by addition thereto, and for providing surface effects to a substrate treated with a composition containing the fluorophosphate.Type: GrantFiled: May 19, 2008Date of Patent: November 1, 2011Assignee: E.I. du Pont de Nemours and CompanyInventors: Weiming Qiu, Xiuling Shirley Wang
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Publication number: 20110245188Abstract: The present invention relates to methods and compositions of treating or preventing inflammatory diseases or conditions in a patient comprising administering to the patient a therapeutically effective amount of a composition comprising a glutathione donor, 5-amino 4-imidazolecarboxamide ribotide (AICAR), a 3-hydroxy-3-methylgluatryl-coenzymeA (HMG-CoA) reductase inhibitor, D-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol HCl (D-PDMP), and/or 1,5-(butylimino)-1,5-dideoxy-D-glucitol (Miglustat), or derivatives thereof.Type: ApplicationFiled: March 25, 2011Publication date: October 6, 2011Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENTInventor: Inderjit Singh
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Publication number: 20110236506Abstract: Pharmaceutical combination containing lipoic acid and hydroxycitric acid as active ingredients. The present invention relates to a novel pharmaceutical combination and to the use thereof for producing a medicament having an antitumor activity. According to the invention, this combination comprises, as active ingredients: lipoic acid or one of the pharmaceutically acceptable salts thereof; and hydroxycitric acid or one of the pharmaceutically acceptable salts thereof. Said active ingredients being formulated together or separately for a conjugated, simultaneous or separate use.Type: ApplicationFiled: May 3, 2011Publication date: September 29, 2011Applicants: BIOREBUSInventors: Laurent SCHWARTZ, Adeline GUAIS-VERGNE
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Patent number: 8022048Abstract: A novel method and composition for treating vitamin B12 deficiency mammals that fail to respond to oral vitamin B12 therapy.Type: GrantFiled: October 31, 2008Date of Patent: September 20, 2011Assignee: Emisphere Technologies, Inc.Inventors: Cristina Castelli, Laura Kragie
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Publication number: 20110212083Abstract: Compositions which specifically block urokinase receptor (uPAR) in podocytes; compositions which modulate or block soluble urokinase receptor (suPAR); compositions which modulate pathways in which uPAR is associated with, protect against renal diseases or disorders. Methods of treatment in vivo involve use of one or more compositions.Type: ApplicationFiled: November 6, 2009Publication date: September 1, 2011Applicants: University of Miami Office of Technology Transfer, General Hospital Corporation d/b/a Massachusetts General HospitalInventor: Jochen Reiser
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Publication number: 20110207691Abstract: Compositions are provided that contain a combination of a nitric oxide-cobalamin complex along with at least one cobalamin drug conjugate, together with methods for their use in the treatment of neoplastic disease.Type: ApplicationFiled: February 8, 2011Publication date: August 25, 2011Applicant: BEBAAS, INC.Inventor: Chad Brown
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Publication number: 20110207693Abstract: Methods of normalizing vitamin B12 levels in patients with low vitamin B12 and methods of normalizing intersubject variability in the treatment of such patients are described. Methods of reducing MMA and/or homocysteine levels, and pharmaceutical compositions useful to effect such changes are also described.Type: ApplicationFiled: February 23, 2011Publication date: August 25, 2011Applicant: EMISPHERE TECHNOLOGIES, INC.Inventor: Cristina Castelli
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Patent number: 8003138Abstract: The present invention relates to an agent that suppresses appetite and provides quick energy. According to at least one aspect of the present invention, a lollipop is provided that suppresses appetite and provides quick energy. The lollipop is made from a premixed herbal formula that is combined with a hard candy confection base. The herbal premixed formula includes the following active ingredients: Guarana PE 22%; CitriMax®; and L-Tyrosine. The herbal premix formula can also include Vitamin B6; and Vitamin B12 Cyanacobalamin. The premixed formula is added to a candy base that may include corn syrup, Maltodextrin, sugar, natural color and natural flavorings.Type: GrantFiled: May 26, 2009Date of Patent: August 23, 2011Assignee: Fun Unlimited, Inc.Inventor: Michael P. Wenniger
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Patent number: 8003353Abstract: A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cyanocobalamin has a bioavailability of cyanocobalamin when administered intranasally of at least about 7% relative to an intramuscular injection of cyanocobalamin with the proviso that the solution is essentially free of mercury and mercury-containing compounds. The present invention is also directed towards a method for elevating the vitamin B12 levels in the cerebral spinal fluid (CSF) comprising administering intranasally a sufficient amount of a mercury-free cyanocobalamin solution so as to increase the average ratio of vitamin B12 in the CSF to that in the blood serum (B12 CSF/B12 Serum×100) to at least about 1.Type: GrantFiled: June 19, 2008Date of Patent: August 23, 2011Assignee: Par Pharmaceutical, Inc.Inventors: Steven C. Quay, Peter C. Aprile, Zenaida O. Go, Anthony P. Sileno
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Patent number: 7998500Abstract: A composition for the nutritional supplementation of women and a method of administering a composition designed for the nutritional supplementation of women is described. In accordance with one embodiment of the present invention, such a composition comprises vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, vitamin D3, vitamin C, vitamin E, niacin, copper, magnesium, zinc, and iron. In accordance with another embodiment of the present invention, a method of administering a composition designed for the nutritional supplementation of women comprises the step of administering a composition comprising vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, vitamin D3, vitamin C, vitamin E, niacin, copper, magnesium, zinc, and iron.Type: GrantFiled: August 4, 2005Date of Patent: August 16, 2011Assignee: Vertical Pharmaceuticals, Inc.Inventors: Steven A. Squashic, Kevin M. Hudy, David C. Purdy
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Publication number: 20110195123Abstract: Implantable medical device eluting drug locally and in prolonged period is provided, including several types of such a device, the treatment modes of implementation and methods of implantation. The device comprising of polymeric substrate, such as a matrix for example, that is used as the device body, and drugs, and in some cases additional scaffolding materials, such as metals or additional polymers, and materials to enhance visibility and imaging. The selection of drug is based on the advantageous of releasing drug locally and in prolonged period, where drug is released directly to the extracellular matrix (ECM) of the diseased area such as tumor, inflammation, degeneration or for symptomatic objectives, or to injured smooth muscle cells, or for prevention. One kind of drug is the gene silencing drugs based on RNA interference (RNAi), including but not limited to si RNA, sh RNA, or antisense RNA/DNA, ribozyme and nucleoside analogs.Type: ApplicationFiled: June 28, 2009Publication date: August 11, 2011Applicant: SILENSEED LTD.Inventor: Amotz Shemi
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Patent number: 7994304Abstract: The invention provides a family of tethered nucleotide analogs useful in sequencing nucleic acids containing a homopolymer region comprising, for example, two or more base repeats, and to sequencing methods using such tethered nucleotide analogs.Type: GrantFiled: October 30, 2007Date of Patent: August 9, 2011Assignee: Helicos Biosciences CorporationInventors: Suhaib Siddiqi, Hernan Orgueira, Edyta Olejnik, Subramanian Marappan, Philip R. Buzby, Atanu Roy
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Patent number: 7994217Abstract: Multivitamin/Multimineral supplements are provided for supplementing iron and desirable nutrients in the diet of mammals. The supplements include an iron-amino acid chelate, a form of iron more bioavailable than traditional iron salts. The supplements may further include a pharmaceutically accepted salt form of iron as well as other nutritional vitamins and minerals. The supplements are useful for providing iron for pregnant and lactating females as well as for persons suffering from anemia.Type: GrantFiled: February 27, 2003Date of Patent: August 9, 2011Assignee: Xanodyne Pharmaceuticals, Inc.Inventors: Prasad Nidamarty, William R. Hurd, Roland J. Bydlon, William C. Williams, Michael Dempsey, Amy Erbskorn
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Patent number: 7994143Abstract: The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.Type: GrantFiled: June 9, 2010Date of Patent: August 9, 2011Assignees: Chimerix, Inc., The Regents of the University of CaliforniaInventors: Karl Y. Hostetler, James R. Beadle, Jacqueline Ruiz, Merrick R. Almond, George R. Painter, Timothy A. Riley, Paula Francom
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Patent number: 7985737Abstract: Described herein is a method for reducing levels of the harmful metabolic waste product of S-adenosylmethionine (SAMe), homocysteine, and provide vitamin and other nutritional co-factors that reduce the production of homocysteine and either re-methylate homocysteine back to S-adenosylmethionine, or facilitate its conversion downstream to cystathione. The method of the invention may be achieved by administering 5-methyl tetrahydrofolate, methylcobalamin, and one or more compounds selected from the group consisting of betaine, pyridoxal-5-phosphate, N-acetyl-cysteine, and other cofactors.Type: GrantFiled: September 26, 2008Date of Patent: July 26, 2011Assignee: Fast Balance, Inc.Inventor: Brian D. Halevie-Goldman
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Publication number: 20110177176Abstract: A gel-based comestible and method of preparing same. In one embodiment of the invention, the gel-based comestible is consumed in one bite without the need for a spoon or other utensil, and supplies the consumer with about 200 mg/serving caffeine, 1000 mg/serving taurine, and 100% of the recommended daily allowances of vitamins B3, B5, B6 and B12.Type: ApplicationFiled: January 17, 2011Publication date: July 21, 2011Applicant: PepsiCo, Inc.Inventor: Vidya Sridhar
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Publication number: 20110172171Abstract: The present invention relates to taurine or taurine-like substances for the prevention of brain oedema, particularly brain intramyelinic oedema and more particularly brain intramyelinic oedema induced by an anti-convulsive drug such as vigabatrin. The invention relates to a substance selected from the group consisting of taurine, a taurine precursor, a taurine metabolite, a taurine derivative, a taurine analog and a substance required for the taurine biosynthesis for the prevention of brain oedema.Type: ApplicationFiled: September 4, 2009Publication date: July 14, 2011Inventors: Serge Picaud, José-Alain Sahel, Firas Jammoul
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Publication number: 20110171283Abstract: The present invention relates to a composition containing at least one nutritive, at least one disinfecting or decontaminating and/or at least one protease-inhibiting active compound and/or active compound complex for the external care and/or treatment of wounds of the human or animal body.Type: ApplicationFiled: July 1, 2008Publication date: July 14, 2011Inventor: Birgit Riesinger
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Publication number: 20110171281Abstract: A clear soft vegetarian dosage capsule comprising a first and second biphasic film. The first biphasic film has a plurality of first reservoirs and further comprises a polysaccharide, a seaweed extract, a rheology modifier, a buffer and a plasticizer. The second biphasic film has a plurality of second reservoirs having a formulation identical to the first film to ensure a sealing engagement. A dosage amount is disposed in each of the plurality of the reservoirs forming a plurality of filled reservoirs. The dosage amount is an emulsion, oil, hydrophilic liquid. The first film is extruded or overlaid with the second film allowing each of the plurality of second reservoirs to overlay the filled reservoirs and sealed with pressure and a fusion temperature slightly less than the melting point of the first and second films forming clear soft vegetarian dosage capsules that are blown dry, bonding moisture to the polysaccharide.Type: ApplicationFiled: January 14, 2010Publication date: July 14, 2011Inventor: Karl Wei Cao
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Publication number: 20110172179Abstract: A radioactive protection micronutrient formulation system is provided and the system comprises: a formulation consisting essentially of antioxidants, the antioxidants are selected from the group consisting essentially of vitamin C, vitamin E, N-acetyl cysteine, natural mixed carotenoids, and alpha-lipoic acid, vitamin A (palmitate), vitamin D-3 (cholecalciferol), thiamine mononitrate, riboflavin, niacinamide ascorbate, d-calcium pantothenate, pyridoxine hydrochloride, cyanocobalamin, folic acid, D-Biotin, selenium (1-seleno-methionine), chromium picolinate, zinc glycinate, calcium citrate and magnesium citrate and mixtures thereof; and plus a booster formulation selected from a group consisting essentially of vitamin C, d-alpha tocopheryl acid succinate, alpha tocopherol, N-acetyl cysteine, natural mixed carotenoids and alpha lipoic acid, the formulation is designed to reduce the risk in humans exposed to doses of ionizing radiation of becoming subjected to at least one condition selected from the group consiType: ApplicationFiled: September 25, 2008Publication date: July 14, 2011Inventors: Kedar N. Prasad, Gerald M. Haase, William C. Cole
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Publication number: 20110166097Abstract: The present invention is directed to methods of treating eye disease. In one embodiment, the method can comprise administering a taxane-cobalamin bioconjugate or another taxane compound to a subject to treat the eye disease. In one embodiment, the bioconjugate can be dissolved in an aqueous solution prior to administration.Type: ApplicationFiled: July 21, 2009Publication date: July 7, 2011Applicant: Osiris Therapeutics, Inc.Inventors: John R. Gebhard, Dinesh Patel
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Publication number: 20110158932Abstract: Methods and compositions containing a berberine compound or berberine related or derivative compound are provided for the prevention and treatment of hyperlipidemia, elevated cholesterol, and/or cardiovascular disease in mammalian subjects. The methods and compositions of the invention are effective for prevention and treatment of atherosclerosis, coronary artery disease, angina pectoris, carotid artery disease, stroke, cerebral arteriosclerosis, high blood pressure, myocardial infarction, cerebral infarction, restenosis following balloon angioplasty, intermittent claudication, dyslipidemia post-prandial lipidemia or xanthoma.Type: ApplicationFiled: December 8, 2008Publication date: June 30, 2011Inventors: Jian-Dong Jiang, Jing Wei, Wei-Jia Kong, Li-Xun Zhao, Dan-Qing Song
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Publication number: 20110150854Abstract: It has been discovered that certain natural mRNAs serve as metabolite-sensitive genetic switches wherein the RNA directly binds a small organic molecule. This binding process changes the conformation of the mRNA, which causes a change in gene expression by a variety of different mechanisms. Modified versions of these natural “riboswitches” (created by using various nucleic acid engineering strategies) can be employed as designer genetic switches that are controlled by specific effector compounds. Such effector compounds that activate a riboswitch are referred to herein as trigger molecules. The natural switches are targets for antibiotics and other small molecule therapies.Type: ApplicationFiled: February 23, 2011Publication date: June 23, 2011Inventors: Ronald R. Breaker, Ali Nahvi, Narasimhan Sudarsan, Margaret S. Ebert, Wade Winkler, Jeffrey E. Barrick, John K. Wickiser
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Publication number: 20110150968Abstract: A strip, which is both edible and dissolvable, is provided comprising a film and a dosage of at least 2% of the reference daily intake (RDI) of at least one dietary supplement for malnutrition or to prevent/treat alcohol induced hangovers. A method for treating malnutrition and/or preventing and treating alcohol-induced hangovers using a dissolvable orally administered strip.Type: ApplicationFiled: June 18, 2010Publication date: June 23, 2011Inventor: Alessandra Grassi
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Publication number: 20110135753Abstract: A nutritional supplement comprising the following approximate amounts: Vitamin/mineral Range Vitamin C 60-150 mg Vitamin D (as cholecalciferol) 400-10,000 IU Thiamin (Vitamin B1) 1-50 mg Riboflavin (Vitamin B2) 1-10 mg Vitamin B6 2-50 mg Folic Acid 0.Type: ApplicationFiled: December 4, 2009Publication date: June 9, 2011Inventor: John Wigneswaran
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Publication number: 20110135714Abstract: The present invention relates to a composition for external application for improving a skin disease (e.g. psoriasis). The composition contains adenosyl cobalamin (coenzyme B12), optionally in admixture with other cobalamins. The composition can be present in the form of liposomal preparations, which are made of a phospholipid and cholesterol.Type: ApplicationFiled: January 28, 2011Publication date: June 9, 2011Applicants: Korean Research Institute of Chemical Technology, Hanall Biopharma Co., Ltd.Inventors: Byung Cheol SHIN, Hasoo Seong, Aeri Lee, Jae Yang Kong, Hyae Gyeong Cheon, Young Sik Cho, Sung Soo Jun, Young Gwan Jo
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Publication number: 20110135708Abstract: A new chewing gum comprising a gum member, with a central core or cavity, and a core element located within the central core or cavity. The chewing gum also comprises a dietary supplement, which may be incorporated in the central core, the cavity, or both. The core element can be of a range of consistencies, from fluid to gel-like. Optionally, the gum member may comprise crystals. Additionally, the crystals may comprise a dietary supplement. The chewing gum may be encapsulated with a coating. Multiple dietary supplements, of different or of the same varieties, may be incorporated into the chewing gum.Type: ApplicationFiled: December 7, 2010Publication date: June 9, 2011Inventor: Brent Holland
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Patent number: 7956031Abstract: Formulations are provided for the trigger and release of bioenergy. The formulations generally include a trigger complex, an elemental complex and a coenzyme-vitamin B complex. The trigger complex is high in fiber and includes at least one metal-binding protein in an alkaline buffer system. The elemental complex includes one or more trace element as a suitable salt. The coenzyme-vitamin B complex includes one or more coenzyme, coenzyme precursor and/or B-vitamin. The compositions can be administered orally in a variety of forms.Type: GrantFiled: May 26, 2006Date of Patent: June 7, 2011Assignee: Naidu LPInventors: A. Satyanarayan Naidu, A. G. Tezus Naidu, A. G. Sreus Naidu
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Patent number: 7951975Abstract: A composition comprising a compound of formula (I) or (II): wherein r and q are independently integers of 1 to 3; Rf is linear or branched chain perfluoroalkyl group having 1 to 6 carbon atoms; j is an integer 0 or 1, or a mixture thereof, x is 1 or 2, Z is —O— or —S—, X is hydrogen or M, and M is an ammonium ion, an alkali metal ion, or an alkanolammonium ion is disclosed.Type: GrantFiled: November 20, 2008Date of Patent: May 31, 2011Assignee: E.I. du Pont de Nemours and CompanyInventors: Sheng Peng, Stephen James Getty, Xianjun Meng
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Publication number: 20110123510Abstract: The present invention relates to methods of regulating biological functions in a mammal that are mediated, at least in part, by the circadian clock.Type: ApplicationFiled: September 24, 2010Publication date: May 26, 2011Applicant: WASHINGTON UNIVERSITYInventors: Shin-ichiro Imai, Joseph Bass
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Publication number: 20110112014Abstract: Glycerol-containing solutions are useful for improving both the metabolic and hydration state of fasting individuals. The same solutions can be utilized in persons facing situations where urination is impossible or inconvenient.Type: ApplicationFiled: January 16, 2009Publication date: May 12, 2011Inventor: Stephan Lück
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Publication number: 20110112047Abstract: This disclosure concerns the use of agonists of AMP-activated protein kinase (AMPK) for improving exercise and modifying energy metabolism in a subject. The disclosure also relates to a combination of AMPK and peroxisome proliferator-activated receptor (PPAR) ? agonists for improving exercise performance in a subject, methods for identifying substance-enhanced exercise performance in a subject, and methods for identifying compounds that affect the interaction of PPAR? with exercise-induced kinases.Type: ApplicationFiled: December 29, 2008Publication date: May 12, 2011Inventors: Ronald M. Evans, Vihang A. Narkar, Reuben J. Shaw, Michael Downes, Ruth T. Yu
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Publication number: 20110098238Abstract: A method, computer-readable medium, and system for identifying compounds from chemical libraries that can be used for the therapeutic treatment of a disease or used as lead compounds in a drug development program. In particular, information from homologous proteins is used to predict, for a target protein, molecular functions that can be used to screen libraries of compounds for individual compounds that are predicted to have high binding affinities for the target protein.Type: ApplicationFiled: December 22, 2008Publication date: April 28, 2011Applicant: GEORGIA TECH RESEARCH CORPORATIONInventors: Jeffrey Skolnick, Michal Brylinski
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Publication number: 20110092454Abstract: The present invention provides methods and related kits for treating or preventing a mycoplasma-related bovine disease. In one aspect, for example, a method for treating or preventing a mycoplasma-related bovine disease may include administering to a bovine a therapeutically effective amount of a steroid or a pharmaceutically acceptable salt thereof, and administering to the bovine a therapeutically effective amount of at least one antibiotic.Type: ApplicationFiled: September 30, 2010Publication date: April 21, 2011Inventor: Dean Rimoldi
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Publication number: 20110081385Abstract: Compositions and methods for the regulation of sleep and circadian rhythms are provided. The compositions are nutritional supplements containing melatonin and one or more vitamins that enhance the effectiveness of melatonin. Preferred vitamins include folic acid, riboflavin (vitamin B2), cobalamin (vitamin B12) or pyridoxine (vitamin B6). The compositions beneficially and advantageously regulate sleep when administered to an individual and are administered to a human or animal suffering from an irregular sleep or circadian rhythm or are administered in anticipation of the development of such an irregularity.Type: ApplicationFiled: June 10, 2010Publication date: April 7, 2011Applicant: LifeScape BioSciences Inc.Inventor: Henry D. Cremisi
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Publication number: 20110077194Abstract: A method and medical composition for the treatment and/or prevention of a functional Vitamin B12 deficiency in an individual that is brought about as a consequence of oxidative stress on biochemical pathways. The functional Vitamin B12 deficiency may eventually present as dementia, other neuropsychiatric abnormality and/or vascular disease. The method involves the administration of a medical composition that supplies a cobalt-sulphur bond in the upper ?-ligand of an intracellular cobalamin molecule thereby facilitating intracellular processing of cobalamin. The cobalt-sulphur bond may he provided directly by administration of a thiolatocohalamin, such as glutathianyl-cobalamin or indirectly by the co-administration of Vitamin B12 (or a derivative thereof) with a sulphur-containing molecule, such as glutathione or a precursor thereof.Type: ApplicationFiled: February 16, 2010Publication date: March 31, 2011Inventor: Andrew McCaddon
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Publication number: 20110071101Abstract: The invention is related to phosphorus substituted nucleoside compounds and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.Type: ApplicationFiled: April 9, 2008Publication date: March 24, 2011Inventors: Constantine G. Boojamra, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Alan X. Huang, Choung U. Kim, Thorsten Kirschberg, Christopher P. Lee, David A. Oare, Vidya K. Prasad, Adrian S. Ray, Sundaramoorthi Swaminathan, William J. Watkins
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Publication number: 20110071102Abstract: The invention describes methods and compositions for alleviating recurrent medical afflictions for which anxiety may cause or exacerbate the affliction. A subject suffering from the affliction is treated with a combination of a pharmaceutical that enhances learning, and a second pharmaceutical recognized to be useful for treatment of the affliction. Representative afflictions include insomnia, erectile dysfunction, female sexual dysfunction, neuropathic pain, attention deficit disorder, and depression.Type: ApplicationFiled: November 30, 2010Publication date: March 24, 2011Inventors: Jason P. McDevitt, Michael Davis
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Publication number: 20110065627Abstract: This invention describes a topical delivery mechanism that contains a mixture of cetylated fatty esters that act as transdermal carriers of desired therapeutic molecules. The proposed cetyl fatty ester penetrant-complex (Base CFEP-complex) contains specific cetyl fatty esters, polar solvents, a carrier base (gel, cream, lotion, patch or stick gel), antioxidants and the desired pharmaceutical, cosmetic or antigenic response eliciting molecules that are efficaciously delivered by selectively varying component ratios in the complex.Type: ApplicationFiled: October 29, 2009Publication date: March 17, 2011Applicant: CYMBIOTICS INC.Inventors: Raj R. Barathur, Jack Bain Bookout
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Publication number: 20110065665Abstract: The invention relates to preparations comprising vitamin B12 and a butanol, and to the use of butanol for stabilizing vitamins.Type: ApplicationFiled: November 22, 2010Publication date: March 17, 2011Applicant: BAYER ANIMAL HEALTH GMBHInventors: IRIS HEEP, Hans-Rolf Taterra
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Publication number: 20110059171Abstract: The invention relates to a solid oral pharmaceutical composition combining ketorolac and B-complex consisting of inter alia thiamin, pyridoxine and cyanocobalamin (vitamins B1, B6 and B12 respectively) and/or the pharmaceutically acceptable salts thereof, as well as pharmaceutically acceptable excipients and/or vehicles. The invention also relates to the method for producing the composition and to the use of said composition having a synergistic therapeutic activity, indicated for the treatment of moderate to severe pain or neuralgias in different locations.Type: ApplicationFiled: March 4, 2009Publication date: March 10, 2011Applicant: LABORATORIOS SENOSIAIN S.A. DE C.V.Inventors: Juan Aurelio Senosiain Aguilar, E. Raúl García Salgado López, M. Angélica Arzola Paniagua, Gustavo Barranco Hernández
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Publication number: 20110052645Abstract: An extrusion process comprises extruding a material that is flowable when heated and passing the extrudate thus formed through a nozzle 10 to shape the extrudate into a plurality of substantially uniformly shaped elements such as minispheres or minicapsules.Type: ApplicationFiled: April 25, 2008Publication date: March 3, 2011Inventor: Ivan Coulter
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Publication number: 20110045041Abstract: The present invention relates to methods and compositions for the delivery of cosmetics and medicants. In some embodiments, the invention relates to compositions comprising both hydrophobic and hydrophilic polymers. In preferred embodiments, the invention relates to the delivery of peptides, small molecules and other bioactive compounds using the compositions and methods disclosed herein.Type: ApplicationFiled: March 26, 2009Publication date: February 24, 2011Inventors: Nevenka Golubovic-Liakopoulos, Bhavdeep Shah, Erik Andersen
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Publication number: 20110038950Abstract: The present invention relates to methods and compounds for regulating or enhancing erythropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.Type: ApplicationFiled: July 12, 2010Publication date: February 17, 2011Inventors: Stephen J. Klaus, Christopher J. Molineaux, Thomas B. Neff, Volkmar Guenzler-Pukall, Ingrid Langsetmo Parobok, Todd W. Seeley, Robert C. Stephenson
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Publication number: 20110038940Abstract: A pulverulent composition includes less than 96% in weight, preferably from 10 to 80%, and more preferably from 20% to 70%, of at least a vitamin having a solubility lower than 20 g/L and preferably 1 g/L and more preferably lower than 500 mg/L in aqueous media, the pulverulent composition being stable on storage and having instantaneous dispersion and solubility properties in aqueous solutions.Type: ApplicationFiled: February 6, 2009Publication date: February 17, 2011Applicant: INNOV'IAInventor: Alain Grizeau
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Publication number: 20110038899Abstract: Pharmaceutical solutions containing hydrophobic or lipophilic therapeutic agents and methods for producing the same are provided. Pharmaceutical solutions of the invention are produced by dissolving the therapeutic agent in one or more tocopherols or tocotrienols and one or more alcohols or glycols. These solutions are used to produce pharmaceutical compositions.Type: ApplicationFiled: March 27, 2009Publication date: February 17, 2011Inventors: Garry Thomas Gwozdz, Andrew Loxley, Mark Mitchnick
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Patent number: 7888391Abstract: The present invention relates to the use of polyunsaturated fatty acids and one or more components which have a beneficial effect on total methionine metabolism selected from the group consisting of vitamin B12 and precursors thereof, vitamin B6 and derivatives thereof, folic acid, zinc and magnesium, in the manufacture of a preparation for improving the action of receptors. This preparation is advantageously applied in patients suffering from Parkinson's disease, Huntington's chorea, epilepsy, schizophrenia, paranoia, depression, sleep disorders, impaired memory function, psychoses, dementia and ADHD.Type: GrantFiled: March 10, 2008Date of Patent: February 15, 2011Assignee: N.V. NutriciaInventors: Amanda Johanne Kiliaan, Robert Johan Joseph Hageman
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Publication number: 20110027192Abstract: A fat-burning, energy-producing water composition. The water composition contains spring water and a premeasured, effective amount of L-carnitine dissolved in the spring water at a concentration of no less than 100 mg and no more than 2000 mg per 16 oz of spring water. The water composition may further include at least one nutritious component selected from the group consisting of vitamin B-6, L-Lysine. vitamin B-3, vitamin B-12 and any combination thereof. The water composition may be carbonated or uncarbonated, flavored or flavorless. The water composition in bottled water is administered to a mammal for quenching thirst and increasing fat-burning, improving energy, and keeping body slim and fit.Type: ApplicationFiled: March 9, 2009Publication date: February 3, 2011Inventor: Fabio Lanzoni
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Patent number: 7879349Abstract: A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cyanocobalamin has a bioavailability of cyanocobalamin when administered intranasally of at least about 7% relative to an intramuscular injection of cyanocobalamin with the proviso that the solution is essentially free of mercury and mercury-containing compounds. The present invention is also directed towards a method for elevating the vitamin B12 levels in the cerebral spinal fluid (CSF) comprising administering intranasally a sufficient amount of a mercury-free cyanocobalamin solution so as to increase the average ratio of vitamin B12 in the CSF to that in the blood serum (B12 CSF/B12 Serum×100) to at least about 1.Type: GrantFiled: March 27, 2008Date of Patent: February 1, 2011Assignee: Par Pharmaceutical, Inc.Inventors: Steven C. Quay, Peter C. Aprile, Zenaida O. Go, Anthony P. Sileno
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Publication number: 20110020311Abstract: A novel etiological hypothesis for Multiple Sclerosis (MS) is proposed describing autoimmune attack of ATP: Cob (I) alamin adenosyltransferase (ATR) thereby inhibiting synthesis of (5?-deoxy-5?-adenosyl) cobamide (referred to as 5?-deoxyadenosylcobalmin or AdoCbl) from Vitamin B12 providing a basis for therapeutic design and diagnostic methods. Pharmaceutical compositions for therapy of MS, inflammatory neurological diseases and neurodegenerative diseases utilizing AdoCbl, growth hormone, immunomodulators, interleukins, other therapeutic agents, and physiotherapy are described. Encompassed in embodiments are diagnostic and therapeutic methods based on the amino acid sequence which binds AdoCbl in ATR. A scoping experiment in therapy, parenteral injection of AdoCbl, has been accomplished with a clinically definite MS patient in the Secondary Progressive stage of MS. The dramatic improvement in the patient's condition strongly supports the etiological hypothesis.Type: ApplicationFiled: July 27, 2009Publication date: January 27, 2011Inventor: James Layne Boucher