Polysaccharide Patents (Class 514/54)
  • Patent number: 11123455
    Abstract: The present invention relates to a composition for dermal injection which includes two or more types of cross-linked hyaluronic acid particles having different particle diameters and non-cross-linked hyaluronic acid. The composition for dermal injection according to the present invention satisfies viscosity, extrusion force, and viscoelasticity conditions for dermal injection, and an extrusion force deviation is low so that the user does not feel fatigue when the composition is injected into the dermal thereof. Also, the composition is excellent in viscoelasticity and tissue restoring ability, is maintained for a long period of time, allows rapid recovery because an initial swelling degree is low, and also is excellent in safety and stability in the body.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: September 21, 2021
    Assignees: CG Bio Co., Ltd., DNCompany, Daewoong Pharmaceutical Co., Ltd.
    Inventors: Ji Sun Lee, Su Hyun Jung, Hak Su Jang, Jung Eun Choo, Hye Young Jung
  • Patent number: 11123321
    Abstract: A water soluble iron carbohydrate complex obtainable from an aqueous solution of iron(III) salt and an aqueous solution of the oxidation product of one or more maltrodextrins using an aqueous hypochlorite solution at a pH-value within the alkaline range, where, when one maltodextrin is applied, its dextrose equivalent lies between 5 and 20, and when a mixture of several maltodextrins is applied, the dextrose equivalent of the mixture lies between 5 and 20 and the dextrose equivalent of each individual maltodextrin contained in the mixture lies between 2 and 40, a process for its production and a medicament for the treatment and prophylaxis of iron deficiency conditions.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: September 21, 2021
    Assignee: VIFOR (INTERNATIONAL) AG
    Inventors: Peter Geisser, Erik Philipp, Walter Richie
  • Patent number: 11116779
    Abstract: Disclosed are methods of modulating and/or decreasing serum corticosterone levels in an individual affected by stress. Further disclosed are methods of modulating the hypothalamic pituitary adrenal response in an individual. The methods include administration of 2-fucosyl-lactose to an individual.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: September 14, 2021
    Assignee: ABBOTT LABORATORIES
    Inventors: Enrique Vazquez Hernandez, Ricardo Rueda Cabrera, Rachael Buck, Maria Ramirez Gonzalez
  • Patent number: 11116788
    Abstract: Disclosed is a composition for intravaginal and/or for internal mucosal application, comprising an effective amount of a sulfated polysaccharide, one or more of a natural quaternary polymer, a quaternary molecular compound, a metalloproteinase inhibitor, one or more anti-inflammatory agent, an acid pH control buffering system or any combination thereof, and a pharmaceutically acceptable carrier. Further disclosed is a method of treating or alleviating vaginal infection, vaginal dryness, vaginal or vulvo vaginal atrophy, vaginal itching, dyspareunia, vaginal or vulvar pain, vaginal or perivaginal inflammation or for promoting vaginal or wound healing, vaginal atrophy/dryness caused by radiotherapy, chemotherapy and/or hormonal treatment and decreased vaginal boundary lubrication or a disease or condition associated therewith or of improving vaginal boundary lubrication.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: September 14, 2021
    Assignee: ALGAMED THERAPEUTICS (A.M.T) LTD
    Inventor: Ronnie Klein
  • Patent number: 11110117
    Abstract: Disclosed is a skin preparation composition for external use containing complex hyaluronic acid as an active ingredient, and specifically relates to a skin preparation composition for external use that contains hyaluronic acid, sodium hyaluronate, and hydrolyzed hyaluronic acid as active ingredients, and are excellent in an active oxygen scavenging effect, a wrinkle improvement effect, a moisturizing effect, a skin irritation relief effect, an acne prevention effect, an atopy improvement effect, and an anti-inflammatory effect, an hair damage prevention effect, and a hair loss prevention and hair growth effect.
    Type: Grant
    Filed: January 9, 2020
    Date of Patent: September 7, 2021
    Assignees: J2KBIO CO., LTD., COSMECCA KOREA CO., LTD.
    Inventors: Jae Soeb Lee, Jun Tae Bae, Seok Jong Kim, Young Kwon Cha, Hang Eui Cho, Ju Tae Jeong, Kyeong Seok So
  • Patent number: 11104747
    Abstract: Compositions are disclosed herein comprising a graft copolymer having (i) a backbone comprising dextran with a molecular weight of at least about 100000 Daltons, and poly alpha-1,3-glucan side chains comprising at least about 95% alpha-1,3-glucosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in absorbent materials.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: August 31, 2021
    Assignee: NUTRITION & BIOSCIENCES USA 4, INC.
    Inventors: Natnael Behabtu, Samuel David Arthur
  • Patent number: 11096951
    Abstract: Provided is a prebiotic composition containing butyryl-fructooligosaccharide (B-FOS). B-FOS of the present invention facilitates selective growth of probiotics, thereby controlling intestinal microbes and contributing to physiological functions as an energy source of intestinal epithelial cells.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: August 24, 2021
    Assignee: BIFIDO CO., LTD.
    Inventors: Geun Eog Ji, Min Hee Um, Si Ni Kang, Myeong Soo Park, Bin Kwon
  • Patent number: 11091591
    Abstract: The invention relates to carbohydrate ligands and moieties, respectively, mimicking glycoepitopes comprised by glycosphingolipids of the nervous system, particularly glycoepitopes comprised by glycosphingolipids of the cerebroside, the globoside-, the ganglioside- and the sulfoglucuronyl paragloboside type, which are bound by anti-glycan antibodies associated with neurological diseases. The invention further relates to the use of these carbohydrate ligands/moieties, in diagnosis as well as for the treatment of neurological diseases associated with anti-glycan antibodies. In particular, the invention relates to compounds of formula (I) and (II) and to therapeutically acceptable polymers comprising a multitude of these compounds, including polymers with loading of one compound of formula (I) or (II) or combinations of several compounds of formula (I), and/or (II).
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: August 17, 2021
    Assignee: UNIVERSITÄT BASEL
    Inventors: Ruben Herrendorff, Beat Ernst, Andreas Steck, Hélène Pfister, Giulio Navarra
  • Patent number: 11076623
    Abstract: The invention concerns a method for stimulating barrier integrity in a mammal by administering to a mammal a composition comprising: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (ARA), and at least two distinct oligosaccharides.
    Type: Grant
    Filed: December 7, 2019
    Date of Patent: August 3, 2021
    Assignee: N.V. Nutricia
    Inventors: Eric Alexander Franciscus Van Tol, Linette Eustachia Maria Willemsen, Marleen Antoinette Koetsier, Christopher Beermann, Bernd Stahl
  • Patent number: 11077137
    Abstract: A method for treating diastolic heart failure is provided including identifying a subject having diastolic heart failure and administering a therapeutically effective amount of a galectin-3 inhibitor to the subject to at least partially alleviate a symptom of diastolic heart failure.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: August 3, 2021
    Assignee: Henry Ford Health System
    Inventor: Hani N. Sabbah
  • Patent number: 11077136
    Abstract: The present invention relates to a composition comprising hyaluronic acid, dermatan sulfate, at least one omega-3 fatty acid, and at least one nucleotide. It also relates to the new composition for use in the treatment or prevention of diseases, ailments, dysfunctions, or alterations of the skin, preferably atopic dermatitis. The composition may be in the form of a pharmaceutical composition, food supplement, functional food, or medical food.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: August 3, 2021
    Assignee: BIOIBERICA, S.A.U.
    Inventors: José Escaich Ferrer, Sergi Segarra López, Javier Córdoba Lucio, Jorge Flores García, Alfonso Velasco Franco
  • Patent number: 11066526
    Abstract: A method for cleaving amide bonds, comprising: a) providing a molecule comprising an amide group; b) reacting the molecule comprising an amide group with hydroxylamine (NH2OH) or a salt thereof to cleave the amide bond of the amide group.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: July 20, 2021
    Assignee: Galderma Holding SA
    Inventors: Laura Jing Jing, Craig Steven Harris
  • Patent number: 11065268
    Abstract: The present invention provides a method for the prevention of the incidence of and/or a reduction in the duration of acute diarrhoea, particularly in travelers, said method comprising orally administering an oligosaccharide composition, in particular a non-digestible oligosaccharide, to a mammal.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: July 20, 2021
    Assignee: CLASADO RESEARCH SERVICES LIMITED
    Inventors: Georgios Tzortzis, Glenn R. Gibson
  • Patent number: 11058677
    Abstract: The present invention provides formulations, methods and kits for the treatment of dry eye diseases. In particular, stabilized pharmaceutical compositions comprising the compound of Formula 1 are described herein for a variety of uses including the treatment of dry eye syndrome. In one aspect, methods and ingredients for improving the stability of compositions of the compound of Formula 1 are described.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: July 13, 2021
    Assignee: Novartis AG
    Inventors: Mary Newman, William Hunke
  • Patent number: 11033522
    Abstract: Compositions containing free amino acids have been found to provide effective pain relief in less than five minutes following administration. Suitable compositions include free leucine, free isoleucine, and free valine in a leucine:isoleucine:valine weight ratio of about 1.9:1:1.3. Palatability is improved by the addition of free glycine, such that sweeteners or other flavorants are not necessary. The composition can be a two part formulation in which certain amino acids are provided as a capsule or tablet in order to improve palatability.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: June 15, 2021
    Inventor: David C Scott
  • Patent number: 11028147
    Abstract: Disclosed herein are hydrolyzed collagen compositions. The compositions are inexpensive to make and can be produced without the use of proteolytic enzymes, decolorizing agents, antibacterial and antifungal agents, and the like. Further, the compositions are substantially free of odors and are white to light yellow in color and are suitable to be used as dietary supplements. Also disclosed are methods for producing the compositions.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: June 8, 2021
    Assignee: AVICENNA NUTRACEUTICAL, LLC
    Inventors: Ali Elnajjar, Ali Mourad, Mark Ernst Brandt, Christopher Lippelt
  • Patent number: 11020423
    Abstract: This invention relates generally to compositions and methods for combating inflammatory disease and particularly to the use of food and/or feed compositions for preventing, reducing and/or treating inflammatory disorders, diseases, or discomforts, wherein the compositions comprising at least one specific pectin.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: June 1, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventors: Hendrik Arie Schols, Paulus De Vos, Marco Alexander Van Den Berg, Geert Bruggeman, Erik Martinus Andrianus Maria Bruininx, Neha Mohan Sahasrabudhe, Jan Scholte, Lingmin Tian, Anton Johannes Scheurink
  • Patent number: 11013703
    Abstract: The present invention provides oral solutions containing sotalol hydrochloride which advantageously avoid swallowing while providing with improved stability. The present invention also relates to methods of using the oral solutions for treatment of diseases and disorders, such as delay in reoccurrence of atrial fibrillation/atrial flutter and/or ventricular arrhythmias.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: May 25, 2021
    Assignee: Arbor Pharmaceuticals, LLC
    Inventors: H. Greg Thomas, Jeffrey S. Kiel
  • Patent number: 11008355
    Abstract: An object of the present invention is to provide a crystal of 3?-sialyllactose (hereinafter, referred to as 3SL), which is easily handled, and has high storage stability at normal temperature as well as under high temperature conditions, and provide a process for producing the same. The present invention relates to a 3SL sodium salt n-hydrate (wherein n represents any number of 0 to 9, and when n is 0, it is referred to as 3SL sodium salt anhydrate) and a process for producing the same.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: May 18, 2021
    Assignee: KYOWA HAKKO BIO CO., LTD.
    Inventors: Tomoya Yokoi, Hiroshi Nagano, Kikue Mase, Masahiro Abe
  • Patent number: 10987297
    Abstract: A cosmetic or dermocosmetic agent consisting of galactomannans with molecular masses in a range from 1 to 150 kDa obtained from Caesalpinia spinose and cross-linked sulfated galactans with molar masses in a range from 1 to 150 kDa obtained from Kappaphycus alvarezii. Non-therapeutic cosmetic methods in which the agent is applied on the skin in order to tens the skin and/or to form a film on the skin.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: April 27, 2021
    Assignee: SOCIETE INDUSTRIELLE LIMOUSINE D'APPLICATION BIOLOGIQUE
    Inventor: Jean Paufique
  • Patent number: 10973962
    Abstract: A system, method, and apparatus for treating a tissue site with reduced pressure includes a dressing adapted to be positioned proximate the tissue site. An absorbent may be adapted to be fluidly coupled to the manifold, and an ion exchange member may be adapted to be fluidly coupled between the manifold and the absorbent. A sealing member may be adapted to cover the tissue site to form a sealed space having the manifold disposed therein. A reduced-pressure source may be adapted to be fluidly coupled to the manifold.
    Type: Grant
    Filed: January 8, 2014
    Date of Patent: April 13, 2021
    Assignee: KCI Licensing, Inc.
    Inventors: Timothy Mark Robinson, Christopher Brian Locke
  • Patent number: 10973773
    Abstract: The disclosure provides compositions comprising dactinomycin, formulated for delivery by nanoparticle, and methods for treating a myelodysplastic syndrome (MDS) or cancer, for example, NPM1-mutated acute myeloid leukemia (AML), by administration of the compositions of the disclosure.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: April 13, 2021
    Assignee: Tiziana Life Sciences PLC
    Inventor: Kunwar Shailubhai
  • Patent number: 10967066
    Abstract: An agent comprising: an algin crosslinked with acetal linkages; and at least one cation coupled to the crosslinked algin.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: April 6, 2021
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Abhinav Acharya, Stephen R. Little
  • Patent number: 10959945
    Abstract: The composition is a hydrogel which may be used to deliver therapeutics vaginally. The hydrogel may include a glycosaminoglycan. The glycosaminoglycan may include multiple thiol groups. The composition may also include a molecule that includes at least two thiol reactive sites. The composition may include a mucoadhesive agent as well as a therapeutic agent. The composition may deliver the therapeutic at a pH that is optimal for the vaginal environment, namely between about 3.5 and 5.0.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: March 30, 2021
    Inventors: Marina Lee Gerton, Brenda K. Mann
  • Patent number: 10960081
    Abstract: Iron carbohydrate complex for treatment of fetal metal deficiency Disclosed herein is a pharmaceutical composition comprising an iron carbohydrate complex for use in a method for treatment or prevention of an iron deficiency of a fetus or an infant, wherein the iron carbohydrate complex is administered to the mother of the fetus or infant.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: March 30, 2021
    Assignee: PHARMACOSMOS HOLDING A/S
    Inventors: Lars Lykke Thomsen, Tobias S. Christensen, Hans Andreasen
  • Patent number: 10952799
    Abstract: Provided in accordance with the present disclosure is a diagnostic and a therapeutic bronchoscopy system for localized delivery of medication within the lungs. Specifically, systems and methods are disclosed for creating a functional and anatomical map of the lungs, diagnosing a condition within the lungs, generating a treatment plan for a target site within the lungs, navigating to the target site, administering a treatment directly to the target site for immediate absorption within the target site, and assessing the efficacy of the treatment.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: March 23, 2021
    Assignee: COVIDIEN LP
    Inventor: William S. Krimsky
  • Patent number: 10946038
    Abstract: A method of treating a subject having cancer is described that includes administering a therapeutically effective amount of a ?-(1,3)-(1,4) glucan to the subject. Methods of immunostimulating in a subject by administering an effective amount of a ?-(1,3)-(1,4) glucan to the subject are also described.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: March 16, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Mei Zhang, Alex Y. Huang, Julian Kim
  • Patent number: 10940162
    Abstract: Provided herein are methods of treating ST-elevation myocardial infarction (STEMI) and diseases of the digestion system using ?-1,3/1,6-D-glucan derived from mycelium extract of Ganoderma lucidum. Methods of treating ST-elevation myocardial infarction (STEMI) and diseases of the digestion system using a polysaccharide comprising ?-1,3/1,6-D-glucan are also provided.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: March 9, 2021
    Assignee: PT. Sahabat Lingkungan Hidup
    Inventors: Peter Sugita, Wiwiek Widyastuti Budiliantono, Aurelia Maxine Sugita
  • Patent number: 10933084
    Abstract: The present disclosure relates to pharmaceutical compositions capable of regulating elastic fiber. The disclosure further relates to methods of treating elastic fiber-related disorders, such as COPD, by inhalation of low-molecular weight hyaluronic acid.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: March 2, 2021
    Assignee: MatRx Therapeutics Corporation
    Inventors: Jerome O. Cantor, Gerard M. Turino
  • Patent number: 10918659
    Abstract: The present invention describes a method for preparing a polymannan extract from freeze-dried aloe powder. The polymannan extract of the present invention is further used to formulate a sterile injectable formulation for the treatment of one or more cancers, leukemias and lymphomas, prostate cancer, breast cancer, and colon cancer, immune diseases, particularly immune related neoplasms, acquired immune deficiency syndrome, and hepatitis C.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: February 16, 2021
    Assignee: Bespoke Bioscience, LLC
    Inventor: Ivan E. Danhof
  • Patent number: 10918591
    Abstract: A method of treating skin in need thereof is disclosed. The method can include topically applying to the skin a composition consisting of kakadu plum extract, glycerin, water, and optionally alcohol.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: February 16, 2021
    Assignee: Mary Kay Inc.
    Inventors: David Gan, Michelle Hines, Javier Aravena, Brian Jones
  • Patent number: 10912785
    Abstract: A medical device for the treatment of papilloma virus (HPV) skin infections is the object of this invention, in particular for the treatment of warts and related pathologies. In particular, this invention relates to acetylsalicylic acid for use in the topical treatment, of HPV skin infections in particular benign infections and more in particular warts. Acetylsalicylic acid may be administered by plaster or patch, both in a solid state, such as a tablet, powder or granulate, and by a hydrophilic or hydrophobic gel.
    Type: Grant
    Filed: September 5, 2016
    Date of Patent: February 9, 2021
    Assignee: Poli MD S.R.L.
    Inventor: Elena Poli
  • Patent number: 10898535
    Abstract: The present invention relates to a composition for inhibiting and preventing myopathy comprising a bean leaf extract as an active ingredient. More specifically, the composition has an effect of inhibiting the overexpression of Atrogin1 and Murf1 specifically expressed in myocyte and restoring cell activity of myocyte to inhibit and prevent muscle loss by including the extract of bean leaf at stage R6 to R8 during the growth stage of bean.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: January 26, 2021
    Assignee: AMOREPACIFIC CORPORATION
    Inventors: Byung Gyu Kim, Young-Gyu Kang, Soo Hyun Kim, Chan Woong Park, Hee Young Jeon
  • Patent number: 10899850
    Abstract: Methods for producing refined xylan from a biomass solution, including: (i) providing a biomass solution, which comprises xylan; (ii) concentrating or separating said biomass solution to obtain a xylan concentrate comprising xylan and impurities; (iii) washing and/or extracting the xylan concentrate with a solvent to obtain refined xylan and a solvent stream comprising the solvent and impurities; and (iv) collecting the refined xylan.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: January 26, 2021
    Assignee: Stora Enso OYJ
    Inventors: Jari Kavakka, Mari Granstrom
  • Patent number: 10898508
    Abstract: An oxidized ?-1,4-oligoglucuronic acid, and a preparation method therefor and uses thereof. By using abundant cellulose in the natural world as the raw material, all 6-site hydroxyl groups of the cellulose ?-1,4-polyglucose is oxidized into carboxyl groups to form glucuronic acid under the action of a sodium bromide (NaBr)-2,2,6,6-tetramethyl piperidine oxide (TEMPO)-sodium hypochlorite (NaClO) oxidation system, and the oxidized oligoglucuronic acid having an open ring at an end is prepared by controlling reaction conditions. The compound has obvious anti-cerebral ischemia activity, and can be developed into a potential anti-cerebral ischemia drug.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: January 26, 2021
    Assignee: SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD.
    Inventors: Zhenqing Zhang, Jie Hao, Shichang Sun, Huiling Zhang
  • Patent number: 10874637
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of neurodegeneration in with brain iron accumulation (NBIA). Studying two novel genes, namely, CRAT encoding the carnitine acetyltransferase and REPS1 involved in endocytosis and vesicle transport, and a series of known NBIA genes, the inventors reported on iron overload related to increased levels and abnormal recycling of transferrin receptor as a common feature in NBIA. They ascribe this anomaly, at least in part, to impaired palmitoylation of the receptor as a common consequence of the various disease causing mutations. Finally, the inventors show that Artesunate improved TfR1 palmitoylation in NBIA fibroblasts. In particular, the present invention relates to a method of treating neurodegeneration with brain iron accumulation in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a drug increasing TfR1 palmitoylation.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: December 29, 2020
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ PARIS DESCARTES, FONDATION IMAGING, ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
    Inventors: Anne Agnès Rötig, Anthony Drecourt
  • Patent number: 10874680
    Abstract: The present application provides a method of increasing relative abundance of Oscillospira in gastro-intestinal tract of a subject. The method comprising administering to said subject at least 2.5 g per day of fructo-oligosaccharide, such that the abundance of Oscillospira is increased to a statistically significant level when measured by F-test. A composition for increasing relative abundance of Oscillospira in gastro-intestinal tract of a subject is also disclosed.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: December 29, 2020
    Assignee: Tata Chemicals Limited
    Inventors: Anirban Bhaduri, Ashok Kumar Dubey, Arup Basu
  • Patent number: 10869882
    Abstract: Immune function of an animal can be modulated by administration of a composition that includes beta glucan. The beta glucan can be derived from Euglena, which provides a form of beta glucan that is different from other organisms, where the beta glucan is predominantly unbranched beta-(1,3)-glucan. Beta glucan can also be complexed with a metal, such as zinc, and/or can combined with an animal feed component to form an animal feed composition. Use of such compositions can improve the well being of an animal, and may augment or even replace the use of antibiotics in certain circumstances.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: December 22, 2020
    Assignee: KEMIN INDUSTRIES, INC.
    Inventors: Jeffrey Richard LeBrun, Robert Levine, Geoffrey Paul Horst
  • Patent number: 10869876
    Abstract: The present invention provides a rocuronium preparation with an excellent stability. The rocuronium preparation contains rocuronium and a buffer solution and having an adjusted pH of 3.5 or less (for example, 2.5 to 3.5). The buffer solution may be a citric acid-sodium hydroxide buffer solution, a tartaric acid-sodium hydroxide buffer solution, a potassium hydrogen phthalate-hydrochloric acid buffer solution, a glycine-hydrochloric acid buffer solution, or the like. Such a rocuronium preparation has, for example, after 6-month storage at 40° C., a generation rate of rocuronium-related substance C of 5% or less.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: December 22, 2020
    Assignee: MARUISHI PHARMACEUTICAL CO., LTD.
    Inventors: Yutaka Itsuji, Hironori Nagahara, Keisuke Jinbo
  • Patent number: 10857177
    Abstract: The invention provides various isolated and synthetic forms of lipidated PSA as well as isolated or synthetic forms of the glycolipid component of lipidated PSA, and compositions thereof, methods of making including methods of isolating such forms, and methods of use thereof.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: December 8, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: Sungwhan Oh, Deniz Erturk-Hasdemir, Dennis L. Kasper
  • Patent number: 10857175
    Abstract: The application describes compositions that include maltosyl-isomalto-oligosaccharides with a desirable mass average molecular weight distribution. In some cases, the compositions can contain at least 3% mannitol.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: December 8, 2020
    Assignee: ISOThrive Inc.
    Inventors: Lee Madsen, II, Jack Oswald
  • Patent number: 10849337
    Abstract: Described herein are methods of producing animal feed made up of oligosaccharide compositions, as well as methods of producing such oligosaccharide compositions and animal feed compositions, and methods of using such animal feed compositions to enhance animal growth.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: December 1, 2020
    Assignee: Cadena Bio, Inc.
    Inventors: John M. Geremia, Raffi Mardirosian, Michael J. Gidding, Anastasia V. Murphy
  • Patent number: 10842847
    Abstract: The invention provides a method of treating a degenerative joint disease. The method comprises administering an effective amount of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP). The invention also provides a pharmaceutical product as well as a kit comprising DA-DKP.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: November 24, 2020
    Assignee: Ampio Pharmaceuticals, Inc.
    Inventors: David Bar-Or, James V. Winkler
  • Patent number: 10834949
    Abstract: A method to process microalgae biomass and produce high-value chemicals from microalgae biomass is disclosed. The method uses the same biomass cells to extract more than one component such as lipids, water-soluble chemicals, carotenoids, polysaccharides and algae meal. The method is a sequence of physical and chemical treatments. Water soluble polysaccharides produced by the method exhibit properties of low viscosity at low shear thinning. A method for extracting dietary fiber from microalgal biomass is disclosed. Compositions of water-soluble polysaccharides that are fermented slowly by colon microbiota with less gas production than commercial dietary fiber FOS are disclosed. The present inventions described herein provide a method of improving colon health by increasing butyrate during a microalgal dietary fiber fermenting process by colonic microbiota.
    Type: Grant
    Filed: October 13, 2019
    Date of Patent: November 17, 2020
    Inventor: Mustapha Benmoussa
  • Patent number: 10835540
    Abstract: The invention relates to the use of a pharmaceutical medication comprising an aromatase inhibitor, preferably a steroidal aromatase inactivator and an antioxidant as effective ingredients for the treatment of sex hormone-dependent diseases. Furthermore, the invention relates to a composition comprising an aromatase inhibitor/—inactivator and ?-lipoic acid and/or extract of green tea containing polyphenols. The combination of an aromatase inhibitor and—inactivator and ?-lipoic acid and/or extract of green tea containing polyphenols is particularly suitable for the treatment of sex hormone-dependent diseases as well as for the treatment of benign tumors such as e.g. lipomatoses as occurring in Madelung's disease.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: November 17, 2020
    Assignee: Lucolas-M.D. Ltd.
    Inventor: Alfred Schmidt
  • Patent number: 10821131
    Abstract: The present invention relates to pharmaceutical formulations containing a combination of specific high-molecular weight hyaluronic acid derivatives and chondroitin sulfate to be used in the treatment of osteoarthritis, of subchondral damage, osteoporosis, synovitis, tenosynovitis, tendinitis, tendinosis, as an intra-articular washing liquid and as a viscous substitute of synovial fluid following osteochondral surgery. These formulations are also suitable for the treatment of interstitial cystitis.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: November 3, 2020
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Anna Maria Zanellato, Vincenza Corsa, Giancarlo Carpanese, Monica Campisi
  • Patent number: 10814005
    Abstract: Compositions, specifically a jelly, are provided the use of which composition as an auxiliary means eases the taking of oral medication in solid form, which composition comprises iota-carrageenan as a jellifying agent and citric acid as a salivating agent, characterized in that the composition further comprises maltodextrin. In another aspect, the composition comprises a calcium sequestrant for adjusting Ca-ion activity of the composition. In one embodiment, the composition comprises iota-carrageenan in 0.7-1.0% in mass, citric acid in 0.06-0.07% in mass, maltodextrin in 1.5% in mass, all relative to the total mass of the composition, and an amount of a calcium sequestrant such that the Ca-ion activity of the composition is between 20 ppm and 80 ppm.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: October 27, 2020
    Assignee: PAXTREE LTD.
    Inventor: Ron Bruijns
  • Patent number: 10806821
    Abstract: The disclosure provides hyaluronic acid (HA) gel formulations and methods for treating the appearance of the skin. The formulations contain hyaluronic acid and at least one additional ingredient. Methods for treating lines, wrinkles, fibroblast depletions, and scars with the disclosed composition are provided as well.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: October 20, 2020
    Assignee: ALLERGAN INDUSTRIE, SAS
    Inventors: Cecile Gousse, Pierre F. Lebreton, Nicholas Prost
  • Patent number: 10806169
    Abstract: The present invention discloses a nutritional composition and method of using and making the nutritional composition. The nutritional composition is a hydrolyzed pea protein based nutrient composition for use in both enteral and oral feeding, and provides a non-allergenic diet for providing optimal nutrition to users. The nutritional composition is made from organic and plant-based ingredients. The nutritional composition has pea protein hydrolysates, phytochemical extracts, fatty acids, organic ingredients free of the top eight allergens and corn, and prebiotic fiber. The nutritional composition is provided in liquid form for enteral and/or oral feeding.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: October 20, 2020
    Assignee: Kate Farms, Inc.
    Inventors: Richard Laver, Michelle Laver, Brett Matthews, William Pickar, David Cole, Steven Witherly, Caroline Witherly, Vanessa Millovich, Christina Phreaner
  • Patent number: 10808335
    Abstract: Methods of making polycationic nanofibers by grafting cationic polymers onto electrospun neutral nanofibers and polycationic nanofibers produced by the methods are provided herein. In addition, methods of using the polycationic nanofibers to reduce inflammation, to adsorb anionic compounds such as heparin or nucleic acids, to inhibit the growth of microbes or inhibit the formation of a biofilm are also provided. The polycationic nanofibers may be in a mesh and may be included in a medical device, wound dressing, bandage, or as part of a graft.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: October 20, 2020
    Assignee: Duke University
    Inventors: Bruce A. Sullenger, Hemraj A. Juwarker, Kam W. Leong, Jennifer Gamboa Jackman