Starch Or Derivative Patents (Class 514/60)
  • Patent number: 9681620
    Abstract: The present disclosure relates to barley plants having grain with ultra-high beta-glucan content, methods for constructing said barley plants, grain therefrom and uses thereof. In an exemplary embodiment, present disclosure provides a barley plant having grain with ultra-high beta-glucan content known as CM1.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: June 20, 2017
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventor: Gongshe Hu
  • Patent number: 9421219
    Abstract: To provide an IgA production promoter capable of being easily ingested safely and continually, for example orally and capable of preventing infection by inhibiting the binding of pathogenic microorganisms to alimentary canal mucosa and preventing an allergic reaction by blocking the passage of allergen materials such as pollen and house dust through the wall of the alimentary tract. The present invention consists of an IgA production promoter comprising hydroxypropyl starch as an effective ingredient. The IgA production promoter of the present invention can be safely and continually ingested because the effective ingredient thereof is hydroxypropyl starch used in food and the like, and can prevent infection by inhibiting the binding of pathogenic microorganisms to alimentary canal mucosa and prevent an allergic reaction by blocking the passage of allergen materials such as pollen and house dust through the wall of the alimentary tract.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: August 23, 2016
    Assignee: Matsutani Chemical Industry Co., Ltd.
    Inventors: Makoto Tachibe, Toyohide Nishibata, Shozo Sugano
  • Patent number: 9414992
    Abstract: A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (R; A), (ii) at least one reverse-flight section (D), and (iii) a discharging section (E), wherein the processing elements defining the reverse-flight section (R; D) comprise at least one reverse-flight element (14) which is based on a screw-type element having a conveying direction being opposite to the general conveying direction of the extruder.
    Type: Grant
    Filed: December 2, 2013
    Date of Patent: August 16, 2016
    Assignee: Abbvie Deutschland GmbH & CO KG
    Inventors: Thomas Kessler, Jörg Breitenbach, Christoph Schmidt, Matthias Degenhardt, Jörg Rosenberg, Harald Krull, Gunther Berndl
  • Patent number: 9205027
    Abstract: A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (A), (ii) at least one mixing section (B), and (iii) a discharging section (E), wherein the processing element(s) defining the mixing section (B) comprise(s) a mixing element (11, 12, 13) that is derived from a screw type element (FIG. 2).
    Type: Grant
    Filed: December 2, 2013
    Date of Patent: December 8, 2015
    Assignee: Abbvie Deutschland GmbH & CO KG
    Inventors: Thomas Kessler, Jörg Breitenbach, Christoph Schmidt, Matthias Degenhardt, Jörg Rosenberg, Harald Krull
  • Patent number: 9084902
    Abstract: The invention relates generally to mouth rinses for the prevention and elimination of bad breath as well as for the reduction of oral microorganisms responsible for the development of dental plaque and tooth decay. In particular, the present invention relates to a non-alcohol or reduced alcohol mouth rinses effective at preventing the above-mentioned problems.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: July 21, 2015
    Assignee: McNeil-PPC, Inc.
    Inventors: Carolyn J. Mordas, Robert J. Gambogi
  • Patent number: 8987230
    Abstract: The present invention provides a composition comprising a hyaluronic acid derivative having a crosslinking group(s) and a hydrophilic polysaccharide derivative having a hydrophobic group(s), wherein the hyaluronic acid derivative having a crosslinking group(s) is prepared by crosslinkage formation reaction in hyaluronic acid or a derivative thereof having a crosslinkable group(s) in the presence of the hydrophilic polysaccharide derivative wherein the hydrophilic polysaccharide derivative may have a crosslinkable group(s).
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: March 24, 2015
    Assignees: National University Corporation Tokyo Medical and Dental University, Chugai Seiyaku Kabushiki Kaisha
    Inventors: Kazunari Akiyoshi, Nobuyuki Morimoto, Tai Hirakura, Tsuyoshi Shimoboji
  • Patent number: 8975387
    Abstract: Compositions of matter are provided that include chitosan and a modified carbohydrate. The modified carbohydrate includes a carbohydrate component and a cross linking agent. The modified carbohydrate has increased carboxyl content as compared to an unmodified counterpart carbohydrate. A carboxyl group of the modified carbohydrate is covalently bonded with an amino group of chitosan. The compositions of matter provided herein may include cross linked starch citrate-chitosan and cross linked hemicellulose citrate-chitosan, including foams thereof. These compositions yield excellent absorbency and metal chelation properties. Methods of making cross linked modified carbohydrate-chitosan compounds are also provided.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: March 10, 2015
    Assignee: North Carolina State University
    Inventors: Richard A. Venditti, Joel J. Pawlak, Abdus Salam, Khaled Fathy El-Tahlawy
  • Patent number: 8975240
    Abstract: Peritoneal dialysis solutions including a glucose polymer and methods of using the dialysis solutions are disclosed herein. In a general embodiment, the peritoneal dialysis solution includes a glucose polymer in an amount to provide an increased ultrafiltration fluid volume for a given amount of carbohydrate absorbed compared to conventional dialysis solutions containing icodextrin as the active pharmaceutical ingredient. The increased ultrafiltration fluid volume for a given amount of carbohydrate absorbed is obtained by providing specific combinations of weight-average molecular weight, polydispersity index and concentration of the glucose polymer in the dialysis solution.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: March 10, 2015
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: John Kenneth Leypoldt, Clifford J. Holmes, Sujatha Karoor, Catherine M. Hoff, Leo Martis, Rahul Tandon
  • Patent number: 8951989
    Abstract: A hydrogel tissue adhesive having decreased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide with a water-dispersible, multi-arm polyether amine in the presence of an oligomer additive, which promotes the degradation of the hydrogel. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, such as a hemostat sealant or to prevent undesired tissue-to-tissue adhesions resulting from trauma or surgery.
    Type: Grant
    Filed: April 9, 2010
    Date of Patent: February 10, 2015
    Assignee: Actamax Surgical Materials, LLC
    Inventor: Mark E. Wagman
  • Publication number: 20150037426
    Abstract: A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.
    Type: Application
    Filed: July 2, 2014
    Publication date: February 5, 2015
    Inventor: Xin Ji
  • Patent number: 8912168
    Abstract: A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: December 16, 2014
    Inventor: Xin Ji
  • Patent number: 8906882
    Abstract: Provided herein are methods of treating, suppressing, inhibiting, or preventing allergic rhinitis in a subject comprising the step of administering to a subject a compound comprising a lipid or phospholipid moiety bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: December 9, 2014
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem
    Inventor: Saul Yedgar
  • Patent number: 8895533
    Abstract: The invention relates to a compound, comprising a) a first starch derivative selected from the group consisting of hydroxyalkyl starch, carboxyl alkyl starch, ester starch and arbitrary mixtures thereof, wherein the starch derivative has a mean relative molar mass Mw1 and a degree of molar substitution MS1, and b) a second starch derivative selected from the group consisting of hydroxyalkyl starch, carboxyl alkyl starch, ester starch and arbitrary mixtures thereof, having a mean relative molar mass Mw2 and a degree of molar substitution MS2, characterized in that Mw1 is greater than Mw2 (Mw1>Mw2) and MS2 is greater than MS1 (MS2>MS1).
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: November 25, 2014
    Assignee: B. Braun Melsungen AG
    Inventors: Bernd Meier, Iris Theresia Jankowiak-Meier, Nele Meier, Clara Meier
  • Publication number: 20140343013
    Abstract: Compositions comprising a glycosaminoglycan (e.g., a hyaluronan, hyaluronic acid, hyaluronate, sodium hyaluronate, dermatan sulfate, karatan sulfate, chondroitin 6-sulfate, heparin, etc.) in combination with at least one component selected from; i) polyglycols (e.g., polyethylene glycol), ii) long chain hydroxy polyanionic polysaccharides (e.g., dextran, sodium alginate, alginic acid, propylene glycol alginate, carboxymethyl cellulose and carboxyethyl cellulose, hydroxyl ethyl starch, hydroxyl propyl methyl cellulose, hydroxy propyl ethyl cellulose, hydroxy propyl cellulose, methyl cellulose, polylysine, polyhistidine, polyhydroxy proline, poly ornithine, polyvinyl pyrolidone, polyvinyl alcohol, chitosan, etc.) and iii) long chain Nitrogen containing polymers (e.g., Polylysine, Polyvinylpyrrolidone, and polyvinyl alcohol). The invention also includes methods for using such compositions (e.g., as substance delivery materials, tissue fillers or bulking agents, as moistening or hydrating agents, etc.
    Type: Application
    Filed: April 14, 2014
    Publication date: November 20, 2014
    Applicant: S.K. Pharmaceuticals
    Inventors: Hampar Karageozian, John Park
  • Patent number: 8883762
    Abstract: The present invention provides a solution for peritoneal dialysis, consisting of at least two single solutions which are combined after a heat sterilization and are administered to a patient, the first single solution containing an osmotic and the second single solution containing a buffer, and one of these single solutions or another single solution containing electrolyte salts. Glucose-like degradation and hydrolysis is avoided during sterilization and storage, while maintenance of a neutral mixture pH is achieved by the osmotic comprising a glucose polymer and/or glucose polymer derivative, and the pH of the first single solution being between 3.5 and 5.0. The present invention further discloses a twin-chambered pouch consisting of a plastic pouch with at least one first chamber and a second chamber, the first single solution being included in the first chamber and the second single solution being included in the second chamber.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: November 11, 2014
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventor: Thomas Zimmeck
  • Patent number: 8865678
    Abstract: Universal sensory structurants and compositions comprising the same are described. The universal sensory structurants comprise polysaccharide carbohydrate having at least about 75% by weight amylopectin and the polysaccharide carbohydrate has been treated and swollen with a solvent comprising hydroxylated polymer comprising less than about 100 silane repeat units.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: October 21, 2014
    Assignee: Conopco, Inc.
    Inventor: Jack Polonka
  • Patent number: 8865681
    Abstract: In one embodiment, the invention provides a method of treating, reducing the incidence, reducing the severity or pathogenesis of an eye disease or disorder in a subject, including, inter alia, retinal detachment, macular degeneration, glaucoma or retinopathy, comprising the step of administering an effective amount of a lipid or phospholipid moiety bound optionally via a spacer to a physiologically acceptable monomer, dimer, oligomer, or polymer via an ester or amide bond, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof. This invention also provides a contact lens solution comprising a lipid or phospholipid moiety bound optionally via a spacer to a physiologically acceptable monomer, dimer, oligomer, or polymer via an ester or amide bond, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof.
    Type: Grant
    Filed: November 14, 2007
    Date of Patent: October 21, 2014
    Assignee: Yissum Research Development Company of the Hebrew Unitersity of Jerusalem
    Inventors: Saul Yedgar, Yuval Cohen
  • Patent number: 8840879
    Abstract: Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a covalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: September 23, 2014
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Wolfram Eichner, Martin Schimmel, Frank Hacket, Elmar Kraus, Norbert Zander, Ronald Frank, Harald Conradt, Klaus Langer, Michele Orlando, Klaus Sommermeyer
  • Publication number: 20140212494
    Abstract: A method of treating constipation is disclosed. The method includes administering starch-entrapped microbeads.
    Type: Application
    Filed: September 24, 2012
    Publication date: July 31, 2014
    Inventors: Bruce Hamaker, Ali Keshavarzian, Mark D. Cisneros, Amandeep Kaur, Heather Rasmussen
  • Patent number: 8778326
    Abstract: A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized polysaccharide containing pendant aldehyde groups with a water-dispersible, multi-arm amine is described. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a more rapid degradation time, such as the prevention of undesired tissue-to tissue adhesions resulting from trauma or surgery.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: July 15, 2014
    Assignee: Actamax Surgical Materials, LLC
    Inventors: Helen S. M. Lu, Steven W. Shuey
  • Publication number: 20140179629
    Abstract: Compositions which provide slowly digestible starch and a source of fermentable dietary fiber. Microparticles in which starch is entrapped in a crosslinked matrix to provide dietary benefit. Such microparticles are used to deliver glucose to targeted regions in the small intestine for beneficial physiological effects, and fermentable dietary fiber to the colon to improve colon health and to treat diseases of the colon. Microparticles can be employed to selectively deliver fermentable dietary fiber to targeted portions of the colon.
    Type: Application
    Filed: October 14, 2013
    Publication date: June 26, 2014
    Applicants: RUSH UNIVERSITY MEDICAL CENTER, PURDUE RESEARCH FOUNDATION
    Inventors: BRUCE R. HAMAKER, MAHESH VENKATACHALAM, GENYI ZHANG, ALI KESHAVARZIAN, DEVIN J. ROSE
  • Publication number: 20140171385
    Abstract: Biodegradable materials are formed by mixing together two or more materials which have different resorption times and different mechanical characteristics. Devices formed of these materials can be used in mammals in numerous medical and surgical applications, including those for which the mechanical properties of the device, left in vivo, much change over time.
    Type: Application
    Filed: December 13, 2013
    Publication date: June 19, 2014
    Applicant: ECD MEDICAL
    Inventors: Fred Burbank, Michael Jones
  • Patent number: 8703740
    Abstract: The present invention relates to a composition for preventing tissue adhesion which comprising a bio-compatible hyaluronic acid and a polymer compound. More specifically, the invention is a composition containing hyaluronic acid which has not been modified by a chemical crosslinking or other chemical modification a method for preparing the same, and a composition for adhesion prevention with superior efficacy. The composition of the present invention for preventing adhesion exhibits a physical barrier function and a new adhesion prevention function whereby thrombus formation, which is the basis of adhesion, is inhibited.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: April 22, 2014
    Assignees: Shin Poong Pharmaceutical Co., Ltd., Postech Academy-Industry Foundation
    Inventors: Il Hwan Cho, Sei Kwang Hahn, Eui Jin Hwang, Jang Sik Shin, Junseok Yeom
  • Publication number: 20140105852
    Abstract: A process for making cross-linked polysaccharide gels, particularly cross-linked hyaluronic acid gels, under basic conditions. The resulting gels possess improved degradation characteristics, and are useful in a variety of medical and cosmetic applications.
    Type: Application
    Filed: December 26, 2013
    Publication date: April 17, 2014
    Applicant: Ultraceuticals R&D Pty. Limited
    Inventors: Simone Charlotte Vonwiller, Geoffrey Kenneth Heber
  • Patent number: 8691246
    Abstract: A composition for forming a temporary intestinal occlusion in a mammal is flowable and solidifiable to form a solid plug at a predetermined site in the intestine, the structure of the plug being changeable to allow for a subsequent, at least partial removal of the occlusion. The composition is or comprises a flowable solution, suspension, or dispersion in a solvent or mixed solvent, and comprises the following: a) a suspension of a solid in water or an aqueous mixed solvent, the suspension having a water content which exceeds the flow limit of the suspension by a specific amount; b) a dehydrating agent in an amount which is sufficient to bind the specific amount of water, so that, as a consequence of dehydration, the flow limit of the suspension is exceeded; and c) a means for passivating the dehydrating agent.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: April 8, 2014
    Inventor: Georg Bischof
  • Publication number: 20140073602
    Abstract: The present invention relates to nitric oxide delivering hydroxyalkyl starch derivatives, methods of preparing the same, and specific uses of these hydroxyalkyl starch derivatives.
    Type: Application
    Filed: July 11, 2011
    Publication date: March 13, 2014
    Applicant: FRESENIUS KABI DEUTSCHLAND GMBH
    Inventors: Martin Schimmel, Dominik Heckmann, Cornelius Jungheinrich
  • Publication number: 20140056851
    Abstract: The invention provides methods for promoting weight loss by an animal, promoting weight loss by an animal while preventing or minimizing loss of lean body mass by the animal preventing a reduction in energy metabolism by an animal reducing the risk of regaining weight by an animal after weight loss, and ameliorating undesirable animal behaviors associated with reduced caloric intake by intermittently feeding an animal a first diet containing calories that meet the animal's maintenance energy requirements and a second diet containing calories that do not meet the animal's maintenance energy requirements. In preferred embodiments, the described feeding pattern and diets are ted in conjunction with one or more weight loss agents.
    Type: Application
    Filed: August 22, 2013
    Publication date: February 27, 2014
    Applicant: Nestec SA
    Inventor: Yuanlong Pan
  • Patent number: 8642024
    Abstract: Provided herein is an anhydrous cosmetic composition comprising at least one organic structuring agent, at least one modified starch, at least one wood meal, at least one surfactant, and at least one anhydrous liquid phase. Also provided is a method for cleansing and/or conditioning keratin materials, comprising applying at least one of the anhydrous cosmetic compositions to the keratin materials.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: February 4, 2014
    Assignee: L'Oreal
    Inventors: Céline Sellier, Gérard Gabin
  • Publication number: 20140010887
    Abstract: A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.
    Type: Application
    Filed: September 5, 2013
    Publication date: January 9, 2014
    Inventor: Xin Ji
  • Patent number: 8623842
    Abstract: One aspect of the invention is a method of treating a wound to clot blood. A sponge material is applied to the wound. The sponge comprises a starch having hemostatic properties and at least one binding agent. The sponge may further comprise a porous, flexible material.
    Type: Grant
    Filed: September 26, 2007
    Date of Patent: January 7, 2014
    Assignee: Hemostasis, LLC
    Inventors: Keith A. Roberts, John Henry Burban, Majid Zia, Michael R. Spearman
  • Publication number: 20140005115
    Abstract: Provided herein are methods of treating, suppressing, inhibiting, or preventing bronchitis in a subject comprising the step of administering to a subject a compound comprising a lipid or phospholipid moiety bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof.
    Type: Application
    Filed: March 7, 2013
    Publication date: January 2, 2014
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY
    Inventor: YISSUM RESEARCH DEVELOPMENT COMPAN
  • Patent number: 8618266
    Abstract: The present invention relates to hydroxyalkylstarch (HAS)-polypeptide-conjugate (HAS-polypeptide) comprising one or more HAS molecules, wherein each HAS is conjugated to the polypeptide via a carbohydrate moiety or a thioether as well as to methods for the production thereof. In a preferred embodiment, the polypeptide is erythropoietin (EPO).
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: December 31, 2013
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Harald S. Conradt, Eckart Grabenhorst, Manfred Nimtz, Norbert Zander, Ronald Frank, Wolfram Eichner
  • Publication number: 20130338058
    Abstract: In one embodiment, the invention provides a method of suppressing, inhibiting, preventing, or treating conjunctivitis in a subject, comprising the step of administering an effective amount of a lipid or phospholipid moiety bound via an ester or amide bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof to a subject with conjunctivitis.
    Type: Application
    Filed: January 9, 2013
    Publication date: December 19, 2013
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY
    Inventor: YISSUM RESEARCH DEVELOPMENT COMPANY
  • Publication number: 20130331738
    Abstract: Methods and compositions for potentiating the sonothrombolysis of a thrombus within a circulatory vessel of a patient are described. In particular, a method of performing sonothrombolysis in which a suspension that may include microbubbles, degradable starch nanoparticles, and a tissue permeabilizer is administered to the patient in tandem with the directing of ultrasound pulses at the thrombus is described.
    Type: Application
    Filed: June 11, 2013
    Publication date: December 12, 2013
    Inventor: MICHAEL BORRELLI
  • Publication number: 20130317416
    Abstract: The subject matter of the present invention is a sterile liquid composition dedicated to administration into or through the skin and/or the lips, wherein said composition comprises, in a physiologically acceptable medium, at least one photo-crosslinkable compound, wherein said compound comprises at least one activated photo-dimerizable group having at least one activated double bond and selected from photo-dimerizable groups carrying a stilbazolium function of formula (Ia) or (Ib) and wherein the photo-dimerizable groups carry a styrylazolium function of formula (II), the photo-dimerizable group(s) being carried by a partially or totally hydrolysed poly(vinyl acetate) polymer, a polysaccharide or a polyvinyl alcohol
    Type: Application
    Filed: December 20, 2011
    Publication date: November 28, 2013
    Applicant: L'OREAL
    Inventors: Henri Samain, Jean-Thierry Simonnet
  • Patent number: 8580951
    Abstract: Novel aldehyde-functionalized polysaccharide compositions are described that are more stable in aqueous solution than oxidized polysaccharides or other types of polysaccharides containing pendant aldehyde groups. The aldehyde-functionalized polysaccharides may be reacted with various amine-containing polymers to form hydrogel tissue adhesives and sealants that may be useful for medical applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and preventing post-surgical adhesions.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: November 12, 2013
    Assignee: Actamax Surgical Materials, LLC
    Inventors: Helen S. M. Lu, Steven W. Shuey
  • Patent number: 8580950
    Abstract: Novel aldehyde-functionalized polysaccharide compositions containing pendant dialdehyde groups are described that are more stable in aqueous solution than oxidized polysaccharides. The aldehyde-functionalized polysaccharides may be reacted with various amine-containing polymers to form hydrogel tissue adhesives and sealants that may be useful for medical applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and preventing post-surgical adhesions.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: November 12, 2013
    Assignee: Actamax Surgical Materials, LLC
    Inventors: Helen S. M. Lu, Steven W. Shuey
  • Patent number: 8575132
    Abstract: A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: November 5, 2013
    Inventor: Xin Ji
  • Patent number: 8569480
    Abstract: Described are a hydroxyethylstarch, a process for the preparation thereof, a pharmaceutical formulation containing such a hydroxyethylstarch, and the use of the pharmaceutical formulation for the preparation of a volume replacement, a plasma replacement or a plasma volume expander, as well as the use of the pharmaceutical formulation for maintaining normovolemia and/or for improving the macro- and microcirculation and/or for improving the nutritive oxygen supply and/or for stabilizing hemodynamics and/or for improving the volume efficiency and/or for reducing the plasma viscosity and/or for increasing anemia tolerance and/or for hemodilution, especially for therapeutic hemodilution in disturbed blood supply and arterial, especially peripheral arterial, occlusive diseases.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: October 29, 2013
    Assignee: B. Braun Melsungen AG
    Inventors: Michael Boll, Andreas Fisch, Donat R. Spahn
  • Patent number: 8557274
    Abstract: Compositions which provide slowly digestible starch and a source of fermentable dietary fiber. Microparticles in which starch is entrapped in a crosslinked matrix to provide dietary benefit. Such microparticles are used to deliver glucose to targeted regions in the small intestine for beneficial physiological effects, and fermentable dietary fiber to the colon to improve colon health and to treat diseases of the colon. Microparticles can be employed to selectively deliver fermentable dietary fiber to targeted portions of the colon. A method for making the microparticles is provided as well as methods for using the microparticles for controlled digestion of starch on ingestion in the small intestine and methods for using the microparticles to deliver dietary fiber. The microparticles with entrapped starch provide a low glycemic index and extended glucose release in food products and food ingredients.
    Type: Grant
    Filed: December 6, 2006
    Date of Patent: October 15, 2013
    Assignees: Purdue Research Foundation, Rush University Medical Center
    Inventors: Bruce R. Hamaker, Mahesh Venktachalam, Genyi Zhang, Ali Keshavarzian, Devin J. Rose
  • Patent number: 8541392
    Abstract: The present invention relates generally to a method of blunting the postprandial glycemic response in a human by feeding an induced viscosity fiber system. The invention also relates to an induced viscosity fiber system and the liquid products that incorporate the induced viscosity fiber system. Further, the invention relates to a method of incorporating soluble fiber into a liquid product without the typical negative organoleptic or physical stability issues. The invention also relates to a method of inducing the feeling of fullness and satiety by feeding the induced viscosity fiber system.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: September 24, 2013
    Assignee: Abbott Laboratories
    Inventors: Bryan W. Wolf, Bruce B. Blidner, Keith A. Garleb, Chron-Si Lai, Timothy W. Schenz
  • Patent number: 8507462
    Abstract: Methods of controlling serum glucose levels in an individual are described, the methods including the step of administering to said individual a therapeutic food composition comprising a waxy and/or hydrothermally treated starch. The method may be used to treat or prevent hypoglycaemia in patients susceptible to hypoglycaemic episodes, for example patients with glycogen storage disease, diabetes or liver disease. The method may also be used in sports nutrition. Also described are compositions for use in the methods.
    Type: Grant
    Filed: November 8, 2004
    Date of Patent: August 13, 2013
    Assignee: Glycologic Limited
    Inventors: Xin Qi, Richard Tester
  • Patent number: 8507461
    Abstract: The present invention relates to compounds which are capable of exerting an inhibitory effect on the Na+ glucose cotransporter SGLT in order to hinder glucose and galactose absorption, as well as on lipase thus reducing dietary triglyceride metabolism, for use in the treatment of conditions which benefit therefrom (diabetes, Metabolic Syndrome, obesity, prevention of weight gain or aiding weight loss). These compounds comprise a non-absorbable, non-digestible polymer having a glucopyranosyl or galactopyranosyl or equivalent moiety stably and covalently linked thereto, said glucopyranosyl or galactopyranosyl moiety being able to occupy the glucose-binding pocket of a SGLT transporter.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: August 13, 2013
    Inventor: Abdalla Rifai
  • Publication number: 20130196949
    Abstract: The present invention relates to hydroxyalkyl starch or a pharmaceutical preparation thereof for the treatment of cancer, tumor or tumor associated diseases, especially by effectively reducing tumor growth rate and inhibiting tumor growth and wherein the hydroxyalkyl starch has a mean molecular weight (MW) above 20 and below 1300 kDa and a molar substitution (MS) in the range of from 0.1 to 1.5, wherein the alkylation may be an ethylation, propylation or butylation or mixes thereof; and wherein the alkyl may be further substituted.
    Type: Application
    Filed: January 30, 2013
    Publication date: August 1, 2013
    Applicant: Fresenius Kabi Deutschland GmbH
    Inventor: Fresenius Kabi Deutschland GmbH
  • Publication number: 20130184237
    Abstract: The present invention relates to nitric oxide delivering hydroxyalkyl starch derivatives, methods of preparing the same, and specific uses of these hydroxyalkyl starch derivatives.
    Type: Application
    Filed: July 11, 2011
    Publication date: July 18, 2013
    Applicant: FRESENIUS KABI DEUTSCHLAND GMBH
    Inventors: Martin Schimmel, Dominik Heckmann, Cornelius Jungheinrich
  • Publication number: 20130171093
    Abstract: A wound healing powder, comprising a sugar selected from the group consisting of one or more pharmaceutically acceptable monosaccharides and disaccharides, in an amount of at least 25% by weight of the powder mixture; and an absorbent agent which forms a bioabsorbable biocompatible matrix with wound secretions, comprising a polymer formed of one or more of saccharide or saccharide derivative monomers and lactic acid monomers, in an amount of at least 25% by weight of the powder mixture.
    Type: Application
    Filed: August 28, 2012
    Publication date: July 4, 2013
    Inventor: Philip A. Marraccini
  • Patent number: 8470802
    Abstract: Sensory modifiers and compositions comprising sensory modifiers are described. The sensory modifiers comprise polysaccharide carbohydrate having at least about 75% by weight amylopectin and the polysaccharide carbohydrate has been treated and swollen with a substantially anhydrous solvent.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: June 25, 2013
    Assignee: Conopco, Inc.
    Inventor: Jack Polonka
  • Patent number: 8470366
    Abstract: The present invention relates to soft pastilles for nicotine replacement therapy, said pastille comprises about 0.05% to about 1% of nicotine active; about 5% to about 40% of gelling agent; about 30% to about 70% of plasticizer; about 0.05% to about 10% of sweetener; 0.5% to about 30% of releasing agent; about 0.05% to about 2% of preservative; about 0.01% to 5% of flavoring agent; and about 5% to about 20% of water.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: June 25, 2013
    Inventor: Jatin Thakkar
  • Patent number: 8466277
    Abstract: The invention relates to a method for coupling low-molecular weight substances to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the low-molecular weight substance is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the low-molecular weight substance which reacts with this aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of said conjugates and compositions for the prophylaxis or therapy of the human or animal body.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: June 18, 2013
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Michele Orlando, Jurgen Hemberger, Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Katharina Lutterbeck, Cornelius Jungheinrich, Roland Scharpf
  • Patent number: 8445460
    Abstract: The invention relates to soluble, highly branched glucose polymers which are obtained by enzymatic treatment of starch, having a reducing sugars content of less than 3.5%, exhibiting a proportion of ?-1,6-glucosidic linkages of between 20% and 30%, a Mw, determined by light scattering, of between 20·103 and 30·103 daltons, and an osmolality of less than 25 mOsm/kg. The invention likewise relates to a method of obtaining these polymers and to their use in the pharmaceutical and food industries, more particularly in the field of enteral and parenteral nutrition, and in the field of peritoneal dialysis.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: May 21, 2013
    Assignee: Roquette Freres
    Inventors: Laëtitia Deremaux, Carole Petitjean, Daniel Wills