Higher Fatty Acid Or Salt Thereof Patents (Class 514/558)
  • Patent number: 10220013
    Abstract: The present disclosure relates to, inter alia, methods of treating mixed dyslipidemia with ethyl eicosapentaenoate.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: March 5, 2019
    Assignee: Amarin Pharmaceuticals Ireland Limited
    Inventors: Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
  • Patent number: 10130600
    Abstract: Methods and compositions for treating Ras-related cancers are provided that involve targeting lipid scavenging. Methods and compositions for identifying and/or characterizing more or less responsive cancers are also provided.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: November 20, 2018
    Assignees: Memorial Sloan Kettering Cancer Center, The Trustees of Princeton University
    Inventors: Joshua Rabinowitz, Jurre Kamphorst, Craig Thompson, Justin Cross
  • Patent number: 10098098
    Abstract: The present disclosure relates to compositions including a fatty acid soap/fatty acid mixture, and methods of use thereof. The compositions include a C5 to C12 fatty acid or mixtures thereof. The compositions show increased activity, e.g., insecticidal, soil removal, antimicrobial activity, at a controlled pH range of about 7.5 to about 9.0.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: October 9, 2018
    Assignee: Ecolab USA Inc.
    Inventors: Victor Fuk-Pong Man, Yvonne Marie Killeen, Michael Charles DeNoma, Kelly J. Herrera, S. John Barcay, William J. Pattison
  • Patent number: 10010506
    Abstract: The invention relates to matrix and layer compositions comprising a first polymer. The matrix and layer compositions are useful in the delivery of bioactives. In particular, the matrices and layers may have advantageous properties including mechanical properties and protection of bioactives and may also provide for pH-dependent release of a bioactive.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: July 3, 2018
    Assignee: Novus International, Inc.
    Inventors: Houston Stephen Smith, Matthew J. Fischer, Graciela B. Arhancet, Rangarani Karnati, John A. Hume, Xiaojun Wang
  • Patent number: 10004685
    Abstract: The present invention is directed to an ophthalmic emulsion. The emulsion has a unique combination of ingredients that promotes the stability of small oil droplets within the emulsion. The emulsion also includes a mucoadhesive polymer that aid in delivering a lipid to the ocular surface.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: June 26, 2018
    Assignee: Alcon Research, Ltd.
    Inventors: Howard Allen Ketelson, David L. Meadows
  • Patent number: 9855237
    Abstract: The present disclosure relates to, inter alia, methods of treating mixed dyslipidemia with ethyl eicosapentaenoate.
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: January 2, 2018
    Assignee: Amarin Pharmaceuticals Ireland Limited
    Inventors: Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
  • Patent number: 9745583
    Abstract: This invention provides a novel delivery means that enables efficient delivery of an active ingredient to a target cell. Such novel delivery means is a liposome for topical administration that consists of dioleylphosphatidylethanolamine (DOPE), phosphatidylcholine, and cationic lipid, that is not modified with PEG, and that is free of cholesterol.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: August 29, 2017
    Assignee: DELTA-FLY PHARMA, INC.
    Inventor: Tatsuhiro Ishida
  • Patent number: 9707160
    Abstract: The present invention relates to a cosmetic composition based on a magnetic or magnetizable material, the preparation thereof and use thereof for surface and deep cleansing of the epidermis. Said cosmetic composition has revealed to be particularly useful for preparing a mask for cleansing the epidermis of the face, breast, hands and body and, simultaneously, for maintaining the aesthetic appearance and functional efficiency thereof.
    Type: Grant
    Filed: October 28, 2008
    Date of Patent: July 18, 2017
    Assignee: DERMOPHISIOLOGIQUE S.R.L.
    Inventor: Carolina Redaelli
  • Patent number: 9668967
    Abstract: The present invention provides a formulation comprising: i) a lipid matrix; ii) at least one thiolated antioxidant; iii) optionally at least one bioactive agent; and iv) optionally at least one chelating agent.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: June 6, 2017
    Assignee: CAMURUS AB
    Inventors: Catalin Nistor, Fredrik Tiberg, Krister Thuresson, Markus Johnsson
  • Patent number: 9532966
    Abstract: The invention relates to the use of specifically designed lipid component with optimal fatty acid profile, an enhanced portion of the palmitic acid residues in the sn-2 position and present as lipid globules with a phospholipid coating for an early in life diet for improving the development of a healthy body composition, in particular prevention of obesity, later in life.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: January 3, 2017
    Assignee: N.V. Nutricia
    Inventors: Eline Marleen Van Der Beek, Marieke Abrahamse-Berkeveld, Annemarie Oosting, Martine Sandra Alles
  • Patent number: 9452151
    Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: September 27, 2016
    Assignee: Amarin Pharmaceuticals Ireland Limited
    Inventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Joseph S. Zakrzewski
  • Patent number: 9445619
    Abstract: Provided herein are exemplary compositions, products, and capsules utilizing POA, EPA, blends of POA and EPA, total algal oil compositions, and/or whole biomass compositions in methods of inhibiting inflammation including in cardiovascular disease, diabetes, obesity, stroke, metabolic syndromes, dementia, Alzheimer's disease, and/or cancer. The exemplary compositions, products, and capsules may be orally, topically, intravenously, and/or subcutaneously administered. The exemplary compositions herein may be used as feed, food, food supplements, beverages, beverage supplements, nutritional products, products for athletic performance, pharmaceutical products, and/or medical products for mammalian use, including humans.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: September 20, 2016
    Assignee: AURORA ALGAE, INC.
    Inventors: James Astwood, Michelle L. Collins, Brian Connolly
  • Patent number: 9415026
    Abstract: Disclosed herein are methods of inactivating and/or decolonizing bacteria on a surface. The present invention also discloses methods for treatment of epithelial conditions caused or aggravated by bacteria, such as acne vulgaris, in a subject in need thereof. The present invention additionally discloses inventive compounds and compositions that exhibit anti-bacterial and/or anti-inflammatory effects.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: August 16, 2016
    Assignee: SIGNUM BIOSCIENCES, INC.
    Inventors: Jeffry B. Stock, Maxwell Stock
  • Patent number: 9392788
    Abstract: Provided are compositions for attracting and/or stimulating oviposition. The compositions comprise a suitable carrier and a bacterium capable of producing nonanoic acid, tetradecanoic acid, or methyl tetradecanoate; Bacillus thuringiensis; Lactococcus lactis; Klebsiella oxytoca; Shigella dysenteriae; Brevundimonas vesicularis; a supernatant of a culture of any of the these bacteria; nonanoic acid; tetradecanoic acid; or methyl tetradecanoate, or any combination thereof, at a concentration effective to attract the mosquito to a target. The compositions may be comprised within a kit or trap. Also provided are methods of attracting mosquitoes to a target.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: July 19, 2016
    Assignee: North Carolina State University
    Inventors: Loganathan Ponnusamy, Ning Xu, Coby Schal, Charles S. Apperson, Dawn Wesson
  • Patent number: 9393224
    Abstract: An object of the present invention is to provide a drug that contains a compound for inhibiting neutral lipid accumulation in cardiovascular tissue or cells and has an excellent prophylactic or therapeutic effect on cardiovascular complications of diabetes. The present invention relates to a prophylactic and/or therapeutic agent for cardiovascular complications of diabetes, the agent containing a compound (preferably a medium-chain fatty acid and/or a medium-chain triglyceride) for inhibiting neutral lipid accumulation.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: July 19, 2016
    Assignees: OSAKA UNIVERSITY, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE, KOWA COMPANY, LTD.
    Inventors: Ken-ichi Hirano, Yoko Yasui, Yoshihiko Ikeda, Mitsutoshi Setou, Nobuhiro Zaima
  • Patent number: 9380780
    Abstract: Microbial growth inhibiting solutions and methods of employing the microbial growth inhibiting solutions in flushing and coating medical devices are disclosed. In alternative embodiments, the microbial growth inhibiting solutions include combinations of a chelating agent with a C4-C9 carboxylate antimicrobial agent, for example, such as n-octanoic acid. Methods of using these microbial growth inhibiting solutions for coating a medical device and for inhibiting catheter infection are also disclosed.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: July 5, 2016
    Inventors: Stanley L. Mills, Jacqueline L. Mills, Robert D. Maurer, Gary L. Rayburn, Marvin A. Cuchens
  • Patent number: 9308189
    Abstract: A composition for treating, ameliorating and/or preventing conditions associated with cognitive decline and/or motor neuron death comprise a fatty acid component enriched for one or more activated fatty acids and a nutraceutically acceptable excipient. A method for treating, ameliorating and/or preventing conditions associated with cognitive decline and/or motor neuron death includes administering a fatty acid component enriched for one or more activated fatty acids.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: April 12, 2016
    Assignee: NITROMEGA CORP.
    Inventor: Raymond A. Miller
  • Patent number: 9295678
    Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: March 29, 2016
    Assignees: The UAB Research Foundation, The State of Oregon Acting By And Through The State Board Of Higher Education On Behalf of The University of Oregon, University College Cardiff Consultants Limited, Morehouse School of Medicine, Inc.
    Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
  • Patent number: 9283166
    Abstract: Compositions and methods for modulating melanogenesis by modifying tyrosinase palmitoylation are provided.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: March 15, 2016
    Assignee: ELC MANAGEMENT LLC
    Inventors: Daniel B. Yarosh, Lieve Declercq, Yoko Niki, Naoaki Saito
  • Patent number: 9259416
    Abstract: A drug for the treatment of cerebrovascular disorders associated with insufficient cerebral circulation such as ischemic stroke, which comprises a pharmaceutically effective amount of a pyrazolone compound of structural Formula (I): or a pharmaceutically acceptable salt thereof, or a pseudo-polymorphic form thereof, administered at a controlled dose so that the plasma concentration of unchanged form is kept constant for a predetermined period of time and so that the compound may exhibit a higher effect.
    Type: Grant
    Filed: August 10, 2005
    Date of Patent: February 16, 2016
    Assignee: MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Satoshi Yuki, Takuma Nakano, Hiroko Suzuki
  • Patent number: 9072296
    Abstract: Microbial growth inhibiting solutions and methods of employing the microbial growth inhibiting solutions in flushing and coating medical devices are disclosed. In alternative embodiments, the microbial growth inhibiting solutions include combinations of a chelating agent with a C4-C9 carboxylate antimicrobial agent, for example, such as n-octanoic acid. Methods of using these microbial growth inhibiting solutions for coating a medical device and for inhibiting catheter infection are also disclosed.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: July 7, 2015
    Assignee: Organic Medical Ventures, L.L.C.
    Inventors: Stanley L. Mills, Jacqueline L. Mills, Robert D. Maurer, Gary L. Rayburn, Marvin A. Cuchens
  • Patent number: 9066902
    Abstract: Compounds of formula I and their metabolites are potent mediators of an inflammatory response: (I) where a, b, c, d, e, f, V, W, X, Y, Ra, Ra?, Rb, Rb?, Rc, and Rc? are defined herein. In particular, the compounds of the invention are candidate therapeutics for treating inflammatory conditions.
    Type: Grant
    Filed: August 2, 2010
    Date of Patent: June 30, 2015
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Bruce A. Freeman, Francisco J. Schopfer
  • Publication number: 20150125923
    Abstract: The present invention generally relates to compositions and methods of delivering substances in a dry mode, wherein the compositions include a surface layer disposed on the outer surface of the composition that is permeable to carbon dioxide and oxygen. The compositions may be used to deliver microorganisms to remove contaminates, such as oil, chemical, waste, or sewage, from soil, water, or air. In other embodiments, the compositions can also be used for delivering liquid food, liquid food additives, liquid biotech agricultural ingredients, conventional liquid agricultural ingredients, liquid human wellness and dietary supplements, and liquid fragrances and beauty products.
    Type: Application
    Filed: October 5, 2011
    Publication date: May 7, 2015
    Applicant: DryLet LLC
    Inventors: Ramiro Trevino, Steven R. Ellis
  • Publication number: 20150110840
    Abstract: A skin cosmetic composition comprising the following components (A), (B), (C), (D), (E) and (F): (A) from 0.5 to 6% by mass of a linear saturated fatty acid having 12 to 22 carbon atoms, (B) from 0.01 to 5% by mass of an organic base, (C) from 0.01 to 1% by mass of an inorganic base, (D) from 0.5 to 6% by mass of a linear saturated alcohol having 12 to 22 carbon atoms, (E) from 0.1 to 20% by mass of an oil agent, and (F) water, in which the total amount of components (A) and (D), [(A)+(D)], is from 2.5 to 12% by mass; the mass ratio (A)/[(A)+(D)], which is the mass ratio of component (A) to the total amount of components (A) and (D), [(A)+(D)], is from 0.2 to 0.7; the molar ratio (B)/[(B)+(C)], which is the molar ratio of component (B) to the total amount of components (B) and (C), [(B)+(C)], is from 5 to 60 mol %; and the molar ratio [(B)+(C)]/(A), which is the molar ratio of the total amount of components (B) and (C), [(B)+(C)], to component (A), is from 10 to 80 mol %.
    Type: Application
    Filed: May 30, 2014
    Publication date: April 23, 2015
    Applicant: Kao Corporation
    Inventors: Tomokazu Yoshida, Hidehiro Nagasawa
  • Patent number: 9012506
    Abstract: Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
    Type: Grant
    Filed: December 1, 2008
    Date of Patent: April 21, 2015
    Assignee: Atrium Medical Corporation
    Inventors: Keith M. Faucher, Hui Tang, Joseph Ferraro, Paul Martakos, Steve A. Herweck, Theodore Karwoski, Scott E. Corbeil
  • Patent number: 9006286
    Abstract: A disinfecting shower cleaner composition including a medium-chain fatty acid coupled with a nonionic surfactant providing temperature stable antimicrobial compositions. The invention specifically relates to antimicrobial compositions including fatty acid antimicrobial agents coupled with an ethoxylated amine and methods of using the antimicrobial compositions.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: April 14, 2015
    Assignee: Ecolab USA Inc.
    Inventors: Elizabeth R. Kiesel, Michael E. Besse, Lisa A. Hellickson, Mark D. Levitt, Daniel E. Pedersen
  • Patent number: 9006214
    Abstract: The present invention is directed to a topical ophthalmic composition for a liquid comprised of clear colloidal polar nanolipids delivered in submicron sized particles, aqueous colloidal lubricants, aqueous polymers, emulsifies, and a unique stabilizing buffer system, which undergoes a liquid-gel phase transition in the eye. Said composition is designed to deliver advanced eye lubricants, protect the three (3) layers of corneal film from dryness, and provide a unique system of Dry Eye treatment that addresses and treats all three layers of corneal tear film. Said composition is further designed to provide a superior delivery system of various Active Pharmaceutical Ingredients (APIs), and/or anti-infective/antibiotic/anti-fungal agents, accepted as safe and efficacious for ophthalmic use.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: April 14, 2015
    Assignee: Altaire Pharmaceutical, Inc.
    Inventor: Assad S. Sawaya
  • Patent number: 9000040
    Abstract: Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
    Type: Grant
    Filed: February 3, 2009
    Date of Patent: April 7, 2015
    Assignee: Atrium Medical Corporation
    Inventors: Keith M. Faucher, Hui Tang, Paul Martakos, Steve A. Herweck, Theodore Karwoski, Allison Sullivan, Greg Melville, Scott E. Corbeil
  • Patent number: 8999400
    Abstract: An aqueous disinfecting solution having a pH of from about 0.5 to about 6 consists essentially of hydrogen peroxide in a concentration of from about 0.05 to about 8 w/w % of the total solution, at least one anionic surfactant in a concentration of from about 0.02 to about 8 w/w % of the total solution, and at least one additional ingredient chosen from benzyl alcohol, an alcohol comprising one to six carbon atoms, and mixtures thereof, in a concentration of from about 0.1 to about 10 w/w % of the total solution.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: April 7, 2015
    Assignee: Virox Technologies Inc.
    Inventors: Jose A. Ramirez, Navid Omidbakhsh
  • Patent number: 9000041
    Abstract: The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: April 7, 2015
    Assignee: Esperion Therapeutics, Inc.
    Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
  • Publication number: 20150094292
    Abstract: Activated fatty acids, topical compositions including activated fatty acids and methods for using activated fatty acids to treat a variety of diseases.
    Type: Application
    Filed: December 8, 2014
    Publication date: April 2, 2015
    Inventor: Raymond A. Miller
  • Patent number: 8993625
    Abstract: A method of parenterally administering a composition, the method including parenterally administering to a person a composition including at least one omega-3 fatty acid and at least one drug, wherein the at least one omega-3 fatty acid source and the at least one drug are administered simultaneously.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: March 31, 2015
    Assignee: Stable Solutions LLC
    Inventor: David F. Driscoll
  • Publication number: 20150086523
    Abstract: The invention is dietary supplements, nutraceutical compositions, medical foods, and animal feeds that have cytoprotective (cell and tissue protection) and health promoting effects. The compositions contain a high dose range of agmatine and nutraceutical acceptable salts thereof as dietary fortification for providing effective long-term cytoprotection and affording for soft stool. The compositions may contain agmatine alone or in combination with other dietary ingredients having health promoting effects. The compositions can be prepared with dietary accepted excipients and compatible forms of carriers, including but not limited to, powders, tablets, capsules, controlled release carriers, lozenges and chewable preparations, liquid suspensions, suspensions in an edible supporting matrix or foodstuff and oral rehydration solutions, to enable consumption of said compositions.
    Type: Application
    Filed: December 1, 2014
    Publication date: March 26, 2015
    Inventors: Gad Gilad, Varda Gilad
  • Patent number: 8987332
    Abstract: The present invention provides methods of treating a ?-arrestin2 mediated and/or GPR120 mediated response in a subject. The ?-arrestin2 mediated and/or GPR120 mediated response can be inflammation, including diabetes, inflammation associated with obesity and obesity. The methods can comprise administering to a subject a therapeutically effective amount of a compound predicted to bind a ?-arrestin2 molecule and/or GPR120, wherein the compound selectively activates a ?-arrestin2-dependent signaling pathway of GPR120.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: March 24, 2015
    Assignee: The Regents of the University of California
    Inventors: Jerrold M. Olefsky, Da Young Oh
  • Patent number: 8975298
    Abstract: The present invention relates to an agent for prevention, treatment or inhibition of symptom progression of a pain and/or for control of an analgesic comprising (2R)-2-propyloctanoic acid, a salt thereof or a prodrug thereof, in which an amount per dose is from 1 mg to 5000 mg (preferably from 10 mg to 5000 mg). By administering (2R)-2-propyloctanoic acid, a salt thereof or a prodrug thereof in an amount per dose within the range as described above, a pain, in particular, a neurogenic pain associated with a disease such as cancer pain, postherpetic pain, diabetic pain, HIV-associated neurogenic pain, calculus-induced pain, neuralgia, orofacial pain or hyperalgesia can be remarkably relieved. Moreover, undesirable effects on the living body relating to the use of an analgesic can be relieved.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: March 10, 2015
    Assignee: ONO Pharmaceutical Co., Ltd.
    Inventor: Hitoshi Maegawa
  • Patent number: 8975299
    Abstract: The subject invention thus provides a composition comprising at least one triglyceride, at least one phospholipid and at least one poly-unsaturated fatty acids (LC-PUFA); wherein at least about 1% of the LC-PUFA in the composition is conjugated to said at least one phospholipid and uses thereof.
    Type: Grant
    Filed: November 2, 2008
    Date of Patent: March 10, 2015
    Assignee: Enzymotec Ltd.
    Inventors: Fabiana Bar Yosef, Dori Pollod, Ariel Katz
  • Patent number: 8962683
    Abstract: The present invention relates to the use of medium chain fatty acids (MCFA), chosen from the group consisting of caproic acid (C6), caprylic acid (C8) and capric acid (C10), salts, derivatives or mixtures thereof, in a total amount by weight comprised between 0.01% and 5% for inhibiting the growth of microbial pathogens.
    Type: Grant
    Filed: June 30, 2005
    Date of Patent: February 24, 2015
    Assignee: Nutrition Sciences NV
    Inventor: Geert Bruggeman
  • Patent number: 8957110
    Abstract: The invention concerns topical compositions for the prevention and treatment of ocular pathologies, in particular inflammatory keratites and conjunctivites and dry eye syndrome, containing as active ingredients polyunsaturated fatty acids of the types omega-3 and omega-6, and specifically EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid) and GLA (?-linolenic acid), mixed with vitamin E acetate and formulated in a stable composition in hydrogel, i.e. in dispersed form in an aqueous vehicle containing one or more gelling polymers. The proposed compositions are particularly indicated for use as artificial tears.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: February 17, 2015
    Assignee: TRB Chemedica International S.A.
    Inventors: Danilo Aleo, Stefano Barabino, Sergio Mangiafico, Maurizio Rolando, Maria Grazia Antonietta Saita
  • Patent number: 8951992
    Abstract: The present invention is directed to methods and compounds for inhibiting bacterial growth and treating a bacterial infection in a subject. These methods involve providing an inhibitor of intrabacterial pH homeostasis, including inhibitors of the Mycobacterium tuberculosis Rv3671c gene encoded membrane protease. Methods for identifying novel compounds that disrupt intrabacterial pH homeostasis and their use for inhibiting bacterial growth and treating a bacterial infection in a subject are also disclosed.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: February 10, 2015
    Assignee: Cornell University
    Inventors: Carl Nathan, Sabine Ehrt, Omar Vandal, Crystal Darby
  • Patent number: 8952057
    Abstract: Compositions containing polymetal complexes are useful in treating anorectal disorders.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: February 10, 2015
    Assignee: JR Chem, LLC
    Inventor: José E. Ramirez
  • Patent number: 8952063
    Abstract: The present invention relates to the field of weight management. The invention particularly relates to a method for inducing satiety. In one of its embodiments, the present invention provides a method for inducing satiety in a human or an animal comprising administering to said human or animal an effective amount of a composition comprising a lipid of which at least part is in a crystal form in the small intestine.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: February 10, 2015
    Assignee: DSM IP Assets B.V.
    Inventors: Arjen Sein, Damiet Josephina Petronella Cunera Koenders, Annika Viberg, Gerardus Johannes Franciscus Smolders, Anthonius Cornelis Van Den Vurg
  • Publication number: 20150025145
    Abstract: The present invention relates to the method of producing an antimicrobial composition characterized in that it comprises the steps of: a) splitting a lauric oil treated with activated carbon; and b) recovering a composition comprising 90% or more, by weight of free fatty acids. The invention further relates to antimicrobial compositions obtained by said process, to feed, food or beverage comprising said composition and to their uses.
    Type: Application
    Filed: March 7, 2013
    Publication date: January 22, 2015
    Applicant: Cargill, Incorporated
    Inventors: Frank Hollander, Marcus Bernardus Kruidenberg, Henricus Wilhelmus Jozef Lobee, Evelien Van Der Hoeven-Hangoo
  • Publication number: 20150017227
    Abstract: Disclosed are methods and compositions for treating skin diseases or conditions with a composition containing a lipid component as an active ingredient.
    Type: Application
    Filed: July 11, 2014
    Publication date: January 15, 2015
    Inventors: Byung Eui Kim, Donald Y.M. Leung
  • Publication number: 20150017217
    Abstract: The present invention provides an insect or arthropod pesticidal composition. The composition includes active ingredients having a mixture of fatty acids, each of the fatty acids having a straight carbon chain from 6 to 12 carbon atoms long. The fatty acid mixture includes a first fatty acid molecule having a straight carbon chain from 6 to 8 carbon atoms long, and a carboxylic acid group. The fatty acid mixture also includes a second fatty acid molecule having a straight carbon chain from 8 to 12 carbon atoms long, and a carboxylic acid group. The composition also includes a carrier that promotes adherence or absorption or transport across the surface of insects or arthropods to effect their incapacitation or death.
    Type: Application
    Filed: May 2, 2014
    Publication date: January 15, 2015
    Applicant: Stratacor, Inc.
    Inventor: William Reifenrath
  • Patent number: 8933126
    Abstract: Mixture of fatty acids, their derivatives, ester or methyl ester derivates thereof, which may be administered to non-human mammals by diffusion in to ambient air during at least seven consecutive days, with a rapid kinetic of diffusion during the first three days of administration.
    Type: Grant
    Filed: May 29, 2009
    Date of Patent: January 13, 2015
    Assignee: Ceva Sante Animale
    Inventors: Benedicte Deminiere, Sandrine Lacoste, Marie-Laure Loubiere
  • Publication number: 20150011632
    Abstract: The present disclosure is related to percarboxylic acid compositions formed in situ in non-equilibrium reactions. The peroxycarboxylic acid compositions are formed using ester based starting materials. Methods for using the percarboxylic acid compositions are also disclosed.
    Type: Application
    Filed: September 26, 2014
    Publication date: January 8, 2015
    Inventors: Junzhong Li, David D. McSherry, Richard Staub
  • Publication number: 20140378544
    Abstract: Methods and systems for on-site, continuous generation of peracid chemistry, namely peroxycarboxylic acids and peroxycarboxylic acid forming compositions, are disclosed. In particular, an adjustable biocide formulator or generator system is designed for on-site generation of peroxycarboxylic acids and peroxycarboxylic acid forming compositions from sugar esters. Methods of using the in situ generated peroxycarboxylic acids and peroxycarboxylic acid forming compositions are also disclosed.
    Type: Application
    Filed: September 8, 2014
    Publication date: December 25, 2014
    Inventors: Paul R. Kraus, Thomas C. Rustad
  • Publication number: 20140377384
    Abstract: The invention encompasses a formulation for hair loss prevention comprising a mixture of water and at least one nonpolar aprotic organic solvent and at least one hair loss preventive ingredient known to inhibit the hormonal mechanism underlying androgenetic hair loss and methods of using the same.
    Type: Application
    Filed: September 14, 2014
    Publication date: December 25, 2014
    Inventor: Giuseppe Trigiante
  • Publication number: 20140371314
    Abstract: This invention relates to deuterated tetramethyl dioic acids, compositions comprising them and uses thereof in the treatment of Metabolic Syndrome and any diseases, disorders or symptoms associated therewith.
    Type: Application
    Filed: December 6, 2012
    Publication date: December 18, 2014
    Inventor: Jacob Bar-Tana
  • Patent number: RE45483
    Abstract: The present invention relates to a method for preventing obesity later in life by administering a certain nutritional composition to an infant with the age between 0 and 36 months. The composition comprises linoleic and alpha-linolenic acid.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: April 21, 2015
    Assignee: N.V. Nutricia
    Inventors: Renate Maria Louise Zwijsen, Gelske Speelmans, Eline Marleen Van Der Beek, Gunther Boehm