Higher Fatty Acid Or Salt Thereof Patents (Class 514/558)
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Patent number: 9259416Abstract: A drug for the treatment of cerebrovascular disorders associated with insufficient cerebral circulation such as ischemic stroke, which comprises a pharmaceutically effective amount of a pyrazolone compound of structural Formula (I): or a pharmaceutically acceptable salt thereof, or a pseudo-polymorphic form thereof, administered at a controlled dose so that the plasma concentration of unchanged form is kept constant for a predetermined period of time and so that the compound may exhibit a higher effect.Type: GrantFiled: August 10, 2005Date of Patent: February 16, 2016Assignee: MITSUBISHI TANABE PHARMA CORPORATIONInventors: Satoshi Yuki, Takuma Nakano, Hiroko Suzuki
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Patent number: 9072296Abstract: Microbial growth inhibiting solutions and methods of employing the microbial growth inhibiting solutions in flushing and coating medical devices are disclosed. In alternative embodiments, the microbial growth inhibiting solutions include combinations of a chelating agent with a C4-C9 carboxylate antimicrobial agent, for example, such as n-octanoic acid. Methods of using these microbial growth inhibiting solutions for coating a medical device and for inhibiting catheter infection are also disclosed.Type: GrantFiled: August 31, 2011Date of Patent: July 7, 2015Assignee: Organic Medical Ventures, L.L.C.Inventors: Stanley L. Mills, Jacqueline L. Mills, Robert D. Maurer, Gary L. Rayburn, Marvin A. Cuchens
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Patent number: 9066902Abstract: Compounds of formula I and their metabolites are potent mediators of an inflammatory response: (I) where a, b, c, d, e, f, V, W, X, Y, Ra, Ra?, Rb, Rb?, Rc, and Rc? are defined herein. In particular, the compounds of the invention are candidate therapeutics for treating inflammatory conditions.Type: GrantFiled: August 2, 2010Date of Patent: June 30, 2015Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Bruce A. Freeman, Francisco J. Schopfer
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Publication number: 20150125923Abstract: The present invention generally relates to compositions and methods of delivering substances in a dry mode, wherein the compositions include a surface layer disposed on the outer surface of the composition that is permeable to carbon dioxide and oxygen. The compositions may be used to deliver microorganisms to remove contaminates, such as oil, chemical, waste, or sewage, from soil, water, or air. In other embodiments, the compositions can also be used for delivering liquid food, liquid food additives, liquid biotech agricultural ingredients, conventional liquid agricultural ingredients, liquid human wellness and dietary supplements, and liquid fragrances and beauty products.Type: ApplicationFiled: October 5, 2011Publication date: May 7, 2015Applicant: DryLet LLCInventors: Ramiro Trevino, Steven R. Ellis
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Publication number: 20150110840Abstract: A skin cosmetic composition comprising the following components (A), (B), (C), (D), (E) and (F): (A) from 0.5 to 6% by mass of a linear saturated fatty acid having 12 to 22 carbon atoms, (B) from 0.01 to 5% by mass of an organic base, (C) from 0.01 to 1% by mass of an inorganic base, (D) from 0.5 to 6% by mass of a linear saturated alcohol having 12 to 22 carbon atoms, (E) from 0.1 to 20% by mass of an oil agent, and (F) water, in which the total amount of components (A) and (D), [(A)+(D)], is from 2.5 to 12% by mass; the mass ratio (A)/[(A)+(D)], which is the mass ratio of component (A) to the total amount of components (A) and (D), [(A)+(D)], is from 0.2 to 0.7; the molar ratio (B)/[(B)+(C)], which is the molar ratio of component (B) to the total amount of components (B) and (C), [(B)+(C)], is from 5 to 60 mol %; and the molar ratio [(B)+(C)]/(A), which is the molar ratio of the total amount of components (B) and (C), [(B)+(C)], to component (A), is from 10 to 80 mol %.Type: ApplicationFiled: May 30, 2014Publication date: April 23, 2015Applicant: Kao CorporationInventors: Tomokazu Yoshida, Hidehiro Nagasawa
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Patent number: 9012506Abstract: Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.Type: GrantFiled: December 1, 2008Date of Patent: April 21, 2015Assignee: Atrium Medical CorporationInventors: Keith M. Faucher, Hui Tang, Joseph Ferraro, Paul Martakos, Steve A. Herweck, Theodore Karwoski, Scott E. Corbeil
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Patent number: 9006214Abstract: The present invention is directed to a topical ophthalmic composition for a liquid comprised of clear colloidal polar nanolipids delivered in submicron sized particles, aqueous colloidal lubricants, aqueous polymers, emulsifies, and a unique stabilizing buffer system, which undergoes a liquid-gel phase transition in the eye. Said composition is designed to deliver advanced eye lubricants, protect the three (3) layers of corneal film from dryness, and provide a unique system of Dry Eye treatment that addresses and treats all three layers of corneal tear film. Said composition is further designed to provide a superior delivery system of various Active Pharmaceutical Ingredients (APIs), and/or anti-infective/antibiotic/anti-fungal agents, accepted as safe and efficacious for ophthalmic use.Type: GrantFiled: August 22, 2013Date of Patent: April 14, 2015Assignee: Altaire Pharmaceutical, Inc.Inventor: Assad S. Sawaya
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Patent number: 9006286Abstract: A disinfecting shower cleaner composition including a medium-chain fatty acid coupled with a nonionic surfactant providing temperature stable antimicrobial compositions. The invention specifically relates to antimicrobial compositions including fatty acid antimicrobial agents coupled with an ethoxylated amine and methods of using the antimicrobial compositions.Type: GrantFiled: May 10, 2011Date of Patent: April 14, 2015Assignee: Ecolab USA Inc.Inventors: Elizabeth R. Kiesel, Michael E. Besse, Lisa A. Hellickson, Mark D. Levitt, Daniel E. Pedersen
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Patent number: 9000040Abstract: Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.Type: GrantFiled: February 3, 2009Date of Patent: April 7, 2015Assignee: Atrium Medical CorporationInventors: Keith M. Faucher, Hui Tang, Paul Martakos, Steve A. Herweck, Theodore Karwoski, Allison Sullivan, Greg Melville, Scott E. Corbeil
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Patent number: 8999400Abstract: An aqueous disinfecting solution having a pH of from about 0.5 to about 6 consists essentially of hydrogen peroxide in a concentration of from about 0.05 to about 8 w/w % of the total solution, at least one anionic surfactant in a concentration of from about 0.02 to about 8 w/w % of the total solution, and at least one additional ingredient chosen from benzyl alcohol, an alcohol comprising one to six carbon atoms, and mixtures thereof, in a concentration of from about 0.1 to about 10 w/w % of the total solution.Type: GrantFiled: March 2, 2012Date of Patent: April 7, 2015Assignee: Virox Technologies Inc.Inventors: Jose A. Ramirez, Navid Omidbakhsh
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Patent number: 9000041Abstract: The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient.Type: GrantFiled: June 24, 2013Date of Patent: April 7, 2015Assignee: Esperion Therapeutics, Inc.Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
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Publication number: 20150094292Abstract: Activated fatty acids, topical compositions including activated fatty acids and methods for using activated fatty acids to treat a variety of diseases.Type: ApplicationFiled: December 8, 2014Publication date: April 2, 2015Inventor: Raymond A. Miller
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Patent number: 8993625Abstract: A method of parenterally administering a composition, the method including parenterally administering to a person a composition including at least one omega-3 fatty acid and at least one drug, wherein the at least one omega-3 fatty acid source and the at least one drug are administered simultaneously.Type: GrantFiled: September 12, 2011Date of Patent: March 31, 2015Assignee: Stable Solutions LLCInventor: David F. Driscoll
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Publication number: 20150086523Abstract: The invention is dietary supplements, nutraceutical compositions, medical foods, and animal feeds that have cytoprotective (cell and tissue protection) and health promoting effects. The compositions contain a high dose range of agmatine and nutraceutical acceptable salts thereof as dietary fortification for providing effective long-term cytoprotection and affording for soft stool. The compositions may contain agmatine alone or in combination with other dietary ingredients having health promoting effects. The compositions can be prepared with dietary accepted excipients and compatible forms of carriers, including but not limited to, powders, tablets, capsules, controlled release carriers, lozenges and chewable preparations, liquid suspensions, suspensions in an edible supporting matrix or foodstuff and oral rehydration solutions, to enable consumption of said compositions.Type: ApplicationFiled: December 1, 2014Publication date: March 26, 2015Inventors: Gad Gilad, Varda Gilad
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Patent number: 8987332Abstract: The present invention provides methods of treating a ?-arrestin2 mediated and/or GPR120 mediated response in a subject. The ?-arrestin2 mediated and/or GPR120 mediated response can be inflammation, including diabetes, inflammation associated with obesity and obesity. The methods can comprise administering to a subject a therapeutically effective amount of a compound predicted to bind a ?-arrestin2 molecule and/or GPR120, wherein the compound selectively activates a ?-arrestin2-dependent signaling pathway of GPR120.Type: GrantFiled: June 11, 2012Date of Patent: March 24, 2015Assignee: The Regents of the University of CaliforniaInventors: Jerrold M. Olefsky, Da Young Oh
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Patent number: 8975298Abstract: The present invention relates to an agent for prevention, treatment or inhibition of symptom progression of a pain and/or for control of an analgesic comprising (2R)-2-propyloctanoic acid, a salt thereof or a prodrug thereof, in which an amount per dose is from 1 mg to 5000 mg (preferably from 10 mg to 5000 mg). By administering (2R)-2-propyloctanoic acid, a salt thereof or a prodrug thereof in an amount per dose within the range as described above, a pain, in particular, a neurogenic pain associated with a disease such as cancer pain, postherpetic pain, diabetic pain, HIV-associated neurogenic pain, calculus-induced pain, neuralgia, orofacial pain or hyperalgesia can be remarkably relieved. Moreover, undesirable effects on the living body relating to the use of an analgesic can be relieved.Type: GrantFiled: June 26, 2006Date of Patent: March 10, 2015Assignee: ONO Pharmaceutical Co., Ltd.Inventor: Hitoshi Maegawa
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Patent number: 8975299Abstract: The subject invention thus provides a composition comprising at least one triglyceride, at least one phospholipid and at least one poly-unsaturated fatty acids (LC-PUFA); wherein at least about 1% of the LC-PUFA in the composition is conjugated to said at least one phospholipid and uses thereof.Type: GrantFiled: November 2, 2008Date of Patent: March 10, 2015Assignee: Enzymotec Ltd.Inventors: Fabiana Bar Yosef, Dori Pollod, Ariel Katz
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Patent number: 8962683Abstract: The present invention relates to the use of medium chain fatty acids (MCFA), chosen from the group consisting of caproic acid (C6), caprylic acid (C8) and capric acid (C10), salts, derivatives or mixtures thereof, in a total amount by weight comprised between 0.01% and 5% for inhibiting the growth of microbial pathogens.Type: GrantFiled: June 30, 2005Date of Patent: February 24, 2015Assignee: Nutrition Sciences NVInventor: Geert Bruggeman
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Patent number: 8957110Abstract: The invention concerns topical compositions for the prevention and treatment of ocular pathologies, in particular inflammatory keratites and conjunctivites and dry eye syndrome, containing as active ingredients polyunsaturated fatty acids of the types omega-3 and omega-6, and specifically EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid) and GLA (?-linolenic acid), mixed with vitamin E acetate and formulated in a stable composition in hydrogel, i.e. in dispersed form in an aqueous vehicle containing one or more gelling polymers. The proposed compositions are particularly indicated for use as artificial tears.Type: GrantFiled: March 18, 2010Date of Patent: February 17, 2015Assignee: TRB Chemedica International S.A.Inventors: Danilo Aleo, Stefano Barabino, Sergio Mangiafico, Maurizio Rolando, Maria Grazia Antonietta Saita
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Patent number: 8952057Abstract: Compositions containing polymetal complexes are useful in treating anorectal disorders.Type: GrantFiled: June 16, 2011Date of Patent: February 10, 2015Assignee: JR Chem, LLCInventor: José E. Ramirez
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Patent number: 8951992Abstract: The present invention is directed to methods and compounds for inhibiting bacterial growth and treating a bacterial infection in a subject. These methods involve providing an inhibitor of intrabacterial pH homeostasis, including inhibitors of the Mycobacterium tuberculosis Rv3671c gene encoded membrane protease. Methods for identifying novel compounds that disrupt intrabacterial pH homeostasis and their use for inhibiting bacterial growth and treating a bacterial infection in a subject are also disclosed.Type: GrantFiled: July 20, 2009Date of Patent: February 10, 2015Assignee: Cornell UniversityInventors: Carl Nathan, Sabine Ehrt, Omar Vandal, Crystal Darby
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Patent number: 8952063Abstract: The present invention relates to the field of weight management. The invention particularly relates to a method for inducing satiety. In one of its embodiments, the present invention provides a method for inducing satiety in a human or an animal comprising administering to said human or animal an effective amount of a composition comprising a lipid of which at least part is in a crystal form in the small intestine.Type: GrantFiled: May 9, 2013Date of Patent: February 10, 2015Assignee: DSM IP Assets B.V.Inventors: Arjen Sein, Damiet Josephina Petronella Cunera Koenders, Annika Viberg, Gerardus Johannes Franciscus Smolders, Anthonius Cornelis Van Den Vurg
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Publication number: 20150025145Abstract: The present invention relates to the method of producing an antimicrobial composition characterized in that it comprises the steps of: a) splitting a lauric oil treated with activated carbon; and b) recovering a composition comprising 90% or more, by weight of free fatty acids. The invention further relates to antimicrobial compositions obtained by said process, to feed, food or beverage comprising said composition and to their uses.Type: ApplicationFiled: March 7, 2013Publication date: January 22, 2015Applicant: Cargill, IncorporatedInventors: Frank Hollander, Marcus Bernardus Kruidenberg, Henricus Wilhelmus Jozef Lobee, Evelien Van Der Hoeven-Hangoo
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Publication number: 20150017227Abstract: Disclosed are methods and compositions for treating skin diseases or conditions with a composition containing a lipid component as an active ingredient.Type: ApplicationFiled: July 11, 2014Publication date: January 15, 2015Inventors: Byung Eui Kim, Donald Y.M. Leung
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Publication number: 20150017217Abstract: The present invention provides an insect or arthropod pesticidal composition. The composition includes active ingredients having a mixture of fatty acids, each of the fatty acids having a straight carbon chain from 6 to 12 carbon atoms long. The fatty acid mixture includes a first fatty acid molecule having a straight carbon chain from 6 to 8 carbon atoms long, and a carboxylic acid group. The fatty acid mixture also includes a second fatty acid molecule having a straight carbon chain from 8 to 12 carbon atoms long, and a carboxylic acid group. The composition also includes a carrier that promotes adherence or absorption or transport across the surface of insects or arthropods to effect their incapacitation or death.Type: ApplicationFiled: May 2, 2014Publication date: January 15, 2015Applicant: Stratacor, Inc.Inventor: William Reifenrath
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Patent number: 8933126Abstract: Mixture of fatty acids, their derivatives, ester or methyl ester derivates thereof, which may be administered to non-human mammals by diffusion in to ambient air during at least seven consecutive days, with a rapid kinetic of diffusion during the first three days of administration.Type: GrantFiled: May 29, 2009Date of Patent: January 13, 2015Assignee: Ceva Sante AnimaleInventors: Benedicte Deminiere, Sandrine Lacoste, Marie-Laure Loubiere
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Publication number: 20150011632Abstract: The present disclosure is related to percarboxylic acid compositions formed in situ in non-equilibrium reactions. The peroxycarboxylic acid compositions are formed using ester based starting materials. Methods for using the percarboxylic acid compositions are also disclosed.Type: ApplicationFiled: September 26, 2014Publication date: January 8, 2015Inventors: Junzhong Li, David D. McSherry, Richard Staub
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Publication number: 20140377384Abstract: The invention encompasses a formulation for hair loss prevention comprising a mixture of water and at least one nonpolar aprotic organic solvent and at least one hair loss preventive ingredient known to inhibit the hormonal mechanism underlying androgenetic hair loss and methods of using the same.Type: ApplicationFiled: September 14, 2014Publication date: December 25, 2014Inventor: Giuseppe Trigiante
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Publication number: 20140378544Abstract: Methods and systems for on-site, continuous generation of peracid chemistry, namely peroxycarboxylic acids and peroxycarboxylic acid forming compositions, are disclosed. In particular, an adjustable biocide formulator or generator system is designed for on-site generation of peroxycarboxylic acids and peroxycarboxylic acid forming compositions from sugar esters. Methods of using the in situ generated peroxycarboxylic acids and peroxycarboxylic acid forming compositions are also disclosed.Type: ApplicationFiled: September 8, 2014Publication date: December 25, 2014Inventors: Paul R. Kraus, Thomas C. Rustad
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Publication number: 20140371314Abstract: This invention relates to deuterated tetramethyl dioic acids, compositions comprising them and uses thereof in the treatment of Metabolic Syndrome and any diseases, disorders or symptoms associated therewith.Type: ApplicationFiled: December 6, 2012Publication date: December 18, 2014Inventor: Jacob Bar-Tana
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Patent number: 8911757Abstract: The present invention provides an insect or arthropod pesticidal composition. The composition includes active ingredients having a mixture of fatty acids, each of the fatty acids having a straight carbon chain from 6 to 12 carbon atoms long. The fatty acid mixture includes a first fatty acid molecule having a straight carbon chain from 6 to 8 carbon atoms long, and a carboxylic acid group. The fatty acid mixture also includes a second fatty acid molecule having a straight carbon chain from 8 to 12 carbon atoms long, and a carboxylic acid group. The composition also includes a carrier that promotes adherence or absorption or transport across the surface of insects or arthropods to effect their incapacitation or death.Type: GrantFiled: April 16, 2010Date of Patent: December 16, 2014Assignee: Stratacor, Inc.Inventor: William Reifenrath
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Patent number: 8912172Abstract: Disclosed is a skin external preparation containing a triterpenic acid typified by ursolic acid. For obtaining a skin external preparation having excellent storage stability by improving the dissolution stability of the triterpenic acid and the like, 4-alkylresorcinol such as 4-n-butylresorcinol is added into a skin external preparation containing a triterpenic acid and the like such as benzyl ursolate.Type: GrantFiled: April 24, 2007Date of Patent: December 16, 2014Assignees: Kuraray Co., Ltd., Pola Chemical Industries Inc.Inventors: Hisashi Akamatsu, Masashi Suzuki, Yuji Sakai
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Publication number: 20140364502Abstract: Lipoic acid derivatives and pharmaceutical formulations containing lipoic acid derivatives are useful in the treatment and prevention of disease characterized by disease cells that are sensitive to lipoic acid derivatives.Type: ApplicationFiled: June 25, 2014Publication date: December 11, 2014Inventors: Paul Bingham, Tom Kwok, Zuzana Zachar
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Patent number: 8906964Abstract: The present invention relates to compositions comprising docosapentaenoic acid and methods of reducing lipid parameters, such as triglycerides, total cholesterol, low density lipoprotein (LDL) cholesterol, non-HDL cholesterol, free fatty acids, and other lipids, comprising administration of omega-3 docosapentaenoic acid.Type: GrantFiled: December 9, 2013Date of Patent: December 9, 2014Assignee: Matinas BioPharma, Inc.Inventors: George Bobotas, Abdel Aziz Fawzy
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Publication number: 20140357718Abstract: The present invention relates to compositions containing organic acids and emulsifiers and their use in controlling intestinal microflora in production animals. In particular, the present invention relates to the use of such compositions for reducing foodborne pathogens.Type: ApplicationFiled: June 2, 2014Publication date: December 4, 2014Applicant: BASF SEInventors: Dieter Feuerstein, Ulrich Roser, Nicolas Vautravers, Gerd Diebold
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Publication number: 20140357706Abstract: Preparation and methods of treating and preventing visceral adiposity and cancer are provided involving the administration of stearate to a subject. It has been unexpectedly discovered that the fatty acid stearate, when introduced in the diet, reduces the amount of visceral fat in the body without decreasing overall body weight or causing measurable negative side effects. It has also been unexpectedly discovered that dietary stearate prevents cancer in healthy subjects and reduces both tumor size and metastasis in subjects already afflicted with cancer.Type: ApplicationFiled: October 15, 2012Publication date: December 4, 2014Applicant: THE UAB RESEARCH FOUNDATIONInventor: Robert W. Hardy
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Publication number: 20140349359Abstract: A process for the use of peracid compositions to eliminate and/or control the growth of undesirable bacteria, including contaminating bacteria, in the fermentation production of alcohol is disclosed. Beneficially, the peracid compositions and methods of use of the same do not interfere or inhibit the growth or replication of yeast and have low or no adverse environmental impact.Type: ApplicationFiled: August 12, 2014Publication date: November 27, 2014Inventors: Peter J. Fernholz, Jay Kummet
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Patent number: 8889398Abstract: The present invention relates generally to the field of prevention of diseases caused by enveloped viruses. More particularly, this invention concerns a composition for inactivating an enveloped virus comprising at least one non phospholipid Lipid Vesicle (nPLV) able to interact with said enveloped virus and an agent that enhances the lipid exchange between said nPLV and the membrane of said enveloped virus.Type: GrantFiled: May 18, 2007Date of Patent: November 18, 2014Assignee: Viroblock SAInventors: Thierry Pelet, Francesca A. Wallach
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Patent number: 8883192Abstract: Compositions useful for weight management in an animal are disclosed. The compositions comprise one or more isoflavones or isoflavone metabolites, and in some embodiments include conjugated linoleic acid, and/or L-carnitine. Also disclosed are methods useful for weight management in an animal utilizing compositions comprising one or more isoflavones, conjugated linoleic acid, and/or L-carnitine. Preferably, the compositions and methods employ a combination of one or more isoflavones, or a combination of one or more isoflavones in conjunction with conjugated linoleic acid, and L-carnitine.Type: GrantFiled: June 4, 2012Date of Patent: November 11, 2014Assignee: Nestec S.A.Inventor: Yuanlong Pan
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Publication number: 20140329811Abstract: The present invention provides a method for preferentially reducing the proliferation of cystic epithelial cells in the kidney or bile duct in a mammal in need thereof by administering a 20-HETE synthesizing enzyme inhibitor or a 20-HETE antagonist to the mammal in an amount sufficient to preferentially reduce the proliferation of cystic epithelial cells over normal epithelial cells such as tubule epithelial cells in the kidney or bile duct. The present invention also provides a method for preventing or treating autosomal dominant polycystic kidney disease (ADPKD), autosomal recessive polycystic kidney disease (ARPKD), ARPKD associated congenital hepatic fibrosis, ARPKD associated Caroli's disease, or cholangiocarcinoma in a mammal in need thereof by administering a 20-HETE synthesizing enzyme inhibitor or a 20-HETE antagonist to the mammal in an amount sufficient to prevent or treat the disease.Type: ApplicationFiled: June 12, 2014Publication date: November 6, 2014Inventors: William E. Sweeney, Ellis D. Avner, Richard J. Roman
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Publication number: 20140329893Abstract: Compositions comprising ketone bodies and/or their metabolic precursors are provided that are suitable for administration to humans and animals and which have the properties of, inter alia, (i) increasing cardiac efficiency, particularly efficiency in use of glucose, (ii) for providing energy source, particularly in diabetes and insulin resistant states and (iii) treating disorders caused by damage to brain cells, particularly by retarding or preventing brain damage in memory associated brain areas such as found in Alzheimer's and similar conditions. These compositions may be taken as nutritional aids, for example for athletes, or for the treatment of medical conditions, particularly those associated with poor cardiac efficiency, insulin resistance and neuronal damage. The invention further provides methods of treatment and novel esters and polymers for inclusion in the compositions of the invention.Type: ApplicationFiled: December 3, 2013Publication date: November 6, 2014Applicant: BTG International LimitedInventor: Richard L. Veech
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Patent number: 8877762Abstract: The present disclosure relates to compositions containing certain pyrimidine compounds such as minoxidil and/or certain pyrimidine sulfate (inner salt) compounds such as minoxidil sulfate and especially compositions containing pyrimidine compounds in combination with an admixtures comprising at least one antioxidant, at least one organic acid and a select fatty acid mixture. The present disclosure also relates to use of the compositions to grow and/or regrow hair and/or prevent hair loss in mammals and particularly in humans.Type: GrantFiled: May 15, 2012Date of Patent: November 4, 2014Assignee: McNeil-PPC, Inc.Inventors: Longsheng Hu, Virginia Streusand Goldman, Josephine A. Minerva, Susan Wendling
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Patent number: 8877812Abstract: Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component.Type: GrantFiled: December 21, 2011Date of Patent: November 4, 2014Assignee: Abbott LaboratoriesInventors: Chron-Si Lai, Keith A. Garleb, John B. Lasekan, Steven R. Davis
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Publication number: 20140322407Abstract: The present invention relates to compositions including medium chain peroxycarboxylic acid, methods for making these compositions, and methods for reducing the population of a microorganism. The compositions can include advantageously high levels of the medium chain peroxycarboxylic acid, can be readily made, and/or can exhibit reduced odor.Type: ApplicationFiled: May 5, 2014Publication date: October 30, 2014Applicant: Ecolab USA Inc.Inventors: Victor F. Man, Joshua P. Magnuson, Steven E. Lentsch
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Publication number: 20140323574Abstract: An infant formula having a relatively high content of triglycerides having palmitic acid in the sn-2 position. The formula may include oligofructose. The formula may also include at least one omega 6 fatty acid and at least one omega 3 fatty acid. The formula may also have a relatively low protein content and an alpha-lactalbumin content similar to human milk The invention also includes a method for improving the stool consistency, increasing bifidobacteria in the colon, reducing potentially pathogenic bacteria in the colon and reducing calcium soaps in the stool of a formula-fed infant.Type: ApplicationFiled: October 29, 2013Publication date: October 30, 2014Inventors: Manjiang Yao, Kalathur S. Ramanujam, Martin Jon Kullen, Margaret Fitzgerald
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Patent number: 8871218Abstract: The present invention relates to a method for preventing obesity later in life by administering a certain nutritional composition to an infant between 0 and 36 months of age.Type: GrantFiled: January 24, 2012Date of Patent: October 28, 2014Assignee: N.V. NutriciaInventors: Renate Maria Louise Zwijsen, Gelske Speelmans, Eline Marleen van der Beek, Gunther Boehm
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Patent number: 8871800Abstract: Methods of utilizing a combined administration or a unit dosage of a combination of an HMG-CoA inhibitor and omega-3 fatty acids for the reduction of apolipoprotein-B levels. The methods are especially useful in the treatment of patients with hypertriglyceridemia or hypercholesterolemia or mixed dyslipidemia, coronary heart disease (CHD), vascular disease, atherosclerotic disease and related conditions, and for the prevention or reduction of cardiovascular, cardiac, and vascular events.Type: GrantFiled: September 17, 2009Date of Patent: October 28, 2014Assignee: GlaxoSmithKline, LLCInventors: Roelof M. L. Rongen, Robert A. Shalwitz, Douglas Kling, Ralph T. Doyle, Jr.
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Publication number: 20140309186Abstract: A method, computer-readable medium, and system for identifying one or more metabolites associated with a disease, comprising: comparing gene expression data from diseased cells to gene expression data from control cells in order to deduce genes that are differentially-regulated in the diseased cells relative to the control cells; based on enzyme function and pathway data for all human metabolites that utilize the genes that are differentially-regulated in the disease cells, identifying one or more metabolites whose intracellular levels are higher or lower in diseased cells than in control cells, and thereby associating the one or more metabolites with the disease.Type: ApplicationFiled: June 24, 2014Publication date: October 16, 2014Inventors: Jeffrey Skolnick, Adrian K. Arakaki, John McDonald, Roman Mezencev, Nathan Bowen
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Patent number: 8853192Abstract: A fat or oil composition containing the following ingredients (A) and (B): (A) 100 parts by weight of a fat or oil containing 15 wt. % or more of diacylglycerols having, in the constituent fatty acids thereof, an unsaturated fatty acid content of 80 wt. % or more, a conjugated linoleic acid content of from 2 to 92 wt. %, and an ?3 unsaturated fatty acid content of less than 15 wt. %; having a monoacylglycerol content of 5 wt. % or less and a free fatty acid content of 5 wt. % or less; and containing 1,3-diacylglycerol/1,2-diacylglycerol at a weight ratio of from 1 to 5; and (B) from 0.001 to 2 parts by weight of a tocopherol.Type: GrantFiled: August 11, 2006Date of Patent: October 7, 2014Assignee: Kao CorporationInventors: Naoki Hosoya, Shin Koike, Takatoshi Murase
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Patent number: RE45483Abstract: The present invention relates to a method for preventing obesity later in life by administering a certain nutritional composition to an infant with the age between 0 and 36 months. The composition comprises linoleic and alpha-linolenic acid.Type: GrantFiled: February 20, 2014Date of Patent: April 21, 2015Assignee: N.V. NutriciaInventors: Renate Maria Louise Zwijsen, Gelske Speelmans, Eline Marleen Van Der Beek, Gunther Boehm