Ring Containing Patents (Class 514/559)
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Patent number: 5420147Abstract: A method for treating skin disorders in warm-blooded animals, said method comprising administering to said warm-blooded animals an effective amount of an appropriately substituted benzimidazole or benzotriazole which suppresses the metabolism of retinoids. Compositions comprising said compounds and an effective amount of a retinoid.Type: GrantFiled: April 26, 1994Date of Patent: May 30, 1995Assignee: Janssen Pharmaceutica N.V.Inventors: Jean P. F. Van Wauwe, Alfons H. M. Raeymaekers
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Patent number: 5376646Abstract: Topical preparations containing a salt of a cholanic acid, a lipid, and optionally, one or more other pharmaceutically or cosmetically active substances, are disclosed. These preparations are used in pharmaceutical and/or cosmetic applications.Type: GrantFiled: June 16, 1993Date of Patent: December 27, 1994Assignee: Hoffmann-La Roche Inc.Inventors: Folker Pittrof, Andreas Supersaxo
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Patent number: 5369126Abstract: A compound of the formula ##STR1## its pharmaceutically acceptable salts, and its pharmaceutically acceptable hydrolyzable esters for reducing sebum secretion and combatting acne as well as oral and topical compositions for use thereof.Type: GrantFiled: January 6, 1993Date of Patent: November 29, 1994Assignee: Hoffmann-La Roche Inc.Inventors: Thomas I. Doran, Michael Rosenberger, Stanley S. Shapiro
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Patent number: 5362751Abstract: The present invention provides a tracheobronchodilator comprising 15-keto-PGEs, reduced in stimuli against bronchi and other side effects.Type: GrantFiled: June 17, 1993Date of Patent: November 8, 1994Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Ryuji Ueno, Tomio Oda
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Patent number: 5360820Abstract: The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel tachykinin antagonists of formula (I), processes for their preparation, pharmaceutical compositions containing them and their medical use. ##STR1## wherein R represents the ring A ##STR2## or 2-pyridinyl or 2-pyridinyl-N-oxide; R.sup.1 is selected from halogen atoms and C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl, and S(O).sub.n C.sub.1-4 alkyl groups;R.sup.2 and R.sup.3, which may be the same or different, each independently are selected from hydrogen and halogen atoms and C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl and cyano groups;n represents zero, 1 or 2;and pharmaceutically acceptable salts and solvates thereof.Type: GrantFiled: September 18, 1992Date of Patent: November 1, 1994Assignee: Glaxo Group LimitedInventors: Russell M. Hagan, Keith T. Bunce, Alan Naylor, Mark Ladlow, Andrew B. McElroy, Andrew R. Whittington, Barry A. Coomber
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Patent number: 5354565Abstract: A biocide composition comprising(A) 1 to 50% by weight of a biocide, and(B) 0.005-60% by weight of a biocide activator having the specific formula is provided. The biocide effect of a biocide can be enhanced with the use of an effective amount of a biocide activator.Type: GrantFiled: April 15, 1992Date of Patent: October 11, 1994Assignee: Kao CorporationInventors: Tetsuji Iwasaki, Tadashi Moriyama, Yuichi Hioki
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Patent number: 5352697Abstract: Storage-stable pesticide compositions comprising azadirachtin or an azadirachtin derivative as the active ingredient and an epoxide as the stabilizing agent.Type: GrantFiled: July 28, 1992Date of Patent: October 4, 1994Assignee: AgriDyne Technologies, Inc.Inventors: Brett J. Butler, William P. Ellenberger, Barry A. Omilinsky
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Patent number: 5352699Abstract: A method for the treatment of vaginal atrophy in a human patient in which retinoic acid is administered topically to the patient's vagina.Type: GrantFiled: November 12, 1993Date of Patent: October 4, 1994Assignee: University of Massachusetts Medical CenterInventor: Connie Jackson
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Patent number: 5334612Abstract: Pharmaceutical compositions containing at least one compound of Formula I, ##STR1## where X is a hydrogen atom or both X's represent a direct link between the two sulphur atoms; Y is hydrogen or C.sub.1 -C.sub.6 alkyl and n represents a number from 1 to 10, or their pharmaceutically acceptable salts including .alpha.-lipoic acid and dihydrolipoic acid. The pharmaceutical compositions are useful for the treatment of diseases caused by retroviruses.Type: GrantFiled: November 8, 1990Date of Patent: August 2, 1994Assignee: ASTA Pharma AktiengesellschaftInventors: Joachim Kalden, Bernhard Fleckenstein, Andreas Baur, Thomas Harrer
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Patent number: 5324748Abstract: A composition of an effective amount of (a) .gamma.-linolenic acid and/or dihomo-.gamma.-linolenic acid, optionally in association with linoleic and if desired other fat acids, said acids being used if desired as physiologically functional derivatives thereof, in conjunction with (b) an effective amount of one or more of natural or synthetic carotenoids or retinoids having, or giving rise in the body to compounds having, Vitamin A activity when used in therapy of a condition in which enhancement of 1-series PG production, or more broadly influence of the 1-series/2-series PG balance in the body in favor of 1-series PGs is required.Type: GrantFiled: October 2, 1992Date of Patent: June 28, 1994Assignee: Efamol LimitedInventor: David F. Horrobin
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Patent number: 5314687Abstract: A peroxyacid antimicrobial concentrate and use composition is provided comprising a C.sub.1 to C.sub.4 peroxycarboxylic acid, and a C.sub.6 to C.sub.18 peroxyacid. The combination of these acids produces a synergistic effect, providing a much more potent biocide than can be obtained by using these components separately. Other components can be added to the composition such as hydrotrope coupling agents, stabilizers, etc. An effective antimicrobial use solution is formed at low concentrations when the concentrate composition is diluted with water to a pH in the range of about 2 to 8. Sanitizing of substantially fixed, "in-place" processing lines in dairies, breweries, and other food processing operations is one utility of the composition.Type: GrantFiled: August 20, 1992Date of Patent: May 24, 1994Assignee: Ecolab Inc.Inventors: Thomas R. Oakes, Patricia M. Stanley, Jerome D. Keller
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Patent number: 5306730Abstract: A botulinum toxin neutralizer comprising at least one fatty acid having the number of carbon atoms of at least 12. Such a fatty acid may be any of saturated fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, nonadecanoic acid, arachidic acid, and behenic acid or any of unsaturated fatty acids such as oleic acid. The toxin neutralizer acts as if it were an antagonistic receptor for botulinum toxin and, when encountering botulinum toxin in human body, directly combines with the toxin and disables the toxin from combining with the neuromuscular tissues of human body to prevent the outbreak of botulism. The toxin thus neutralized and affixed to the botulinum toxin neutralizer is excreted from the human body. The botulinum toxin neutralizer can be manufactured easily and economically from a naturally occurring glyceride and is thus far less costly then the known antitoxin of ganglioside GT1b produced from bovine brain.Type: GrantFiled: May 26, 1992Date of Patent: April 26, 1994Assignee: Kabushiki Kaisha Yakult HonshaInventors: Yoshitaka Nagai, Koutaro Takamizawa, Ryuichiro Tanaka, Hiroo Takayama, Toshizo Sakurai, Masahiko Mutai
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Patent number: 5274002Abstract: Novel trisubstituted phenyl analogs are now found to have activity as for the treatment of congestive heart failure.Type: GrantFiled: September 6, 1990Date of Patent: December 28, 1993Assignee: Warner-Lambert CompanyInventor: Lynn D. Hawkins
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Patent number: 5252604Abstract: Compositions of retinoic acids and tocopherols which may be applied topically without producing retinoic acid-induced skin irritation.Type: GrantFiled: July 10, 1992Date of Patent: October 12, 1993Assignee: Hoffmann-La Roche Inc.Inventors: Christa F. Nagy, Timothy W. Quick, Stanley S. Shapiro
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Patent number: 5200189Abstract: A peroxyacid antimicrobial concentrate and use composition is provided comprising a C.sub.1 to C.sub.4 peroxycarboxylic acid, and a C.sub.6 to C.sub.18 peroxyacid. The combination of these acids produces a synergistic effect, providing a much more potent biocide than can be obtained by using these components separately. Other components can be added to the composition such as hydrotrope coupling agents, stabilizers, etc. An effective antimicrobial use solution is formed at low concentrations when the concentrate composition is diluted with water to a pH in the range of about 2 to 8. Sanitizing of substantially fixed, "in-place" processing lines in dairies, breweries, and other food processing operations is one utility of the composition.Type: GrantFiled: July 23, 1991Date of Patent: April 6, 1993Assignee: Ecolab Inc.Inventors: Thomas R. Oakes, Patricia M. Stanley, Jerome D. Keller
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Patent number: 5190876Abstract: A method and composition for enhancing the action of biological response modifiers, such as promoting cellular differentiation, by using Vitamin A or an analog thereof and sphingosine or an analog thereof.Type: GrantFiled: December 27, 1988Date of Patent: March 2, 1993Assignee: Emory UniversityInventors: Alfred H. Merrill, Jr., Joseph M. Kinkade, Jr., Victoria L. Stevens
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Patent number: 5134163Abstract: Straie distensae lesions may be prevented and/or reduced in size by topically applying to the skin affected with the lesions an effective amount of retinoic acid, preferably by daily application in a dermatologically acceptable vehicle, such as a cream base, at a concentration of about 0.025 to 0.1 weight percent. When applied during the straie rubrae stage, the retinoic acid may be effective to prevent the formation of straie albae lesions, and when applied in either stage, the retinoic acid may be effective to reduce the width and depth of the lesions, with improved texture and softness.Type: GrantFiled: September 1, 1989Date of Patent: July 28, 1992Inventor: Albert M. Kligman
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Patent number: 5132312Abstract: Disclosed are novel 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof.Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.Type: GrantFiled: November 27, 1990Date of Patent: July 21, 1992Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.Inventors: John R. Regan, Kent E. Neuenschwander
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Patent number: 5120716Abstract: A percutaneous absorption promoting agent comprising (A) at least one anionic surfactant and one or two or more of surfactants having a nitrogen atom in the molecule other than anionic surfactants, (B) one or two or more of anionic surfactants and one or two or more of nonionic surfactants not having a nitrogen atom in the molecule, (C) one or two or more of surfactants selected from the group consisting of amphoteric surfactant and semi-polar surfactants and at least one nonionic surfactant having a nitrogen atom in the molecule, (D) one or two or more of surfactants selected from the group consisting of nonionic surfactants, amphoteric surfactants, semi-polar surfactants and cationic surfactants having a nitrogen atom in the molecule, and one or two or more of nonionic surfactants not having a nitrogen atom in the molecule, or (E) an amine oxide as the active ingredient, and a dermatological preparation containing these percutaneous absorption promoting agent and drug components.Type: GrantFiled: October 5, 1988Date of Patent: June 9, 1992Assignee: Shiseido Company Ltd.Inventors: Kiyoshi Miyazawa, Tadahiro Chiba, Yuhei Iwata, Uhei Tamura, Isao Murotani, Shuya Tamaki
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Patent number: 5116981Abstract: This invention encompasses novel analogs of Leukotriene B.sub.4 which are selected from a compound of formula I, B--C.apprxeq.C--CH.sub.2 C(M.sub.2)--C.apprxeq.C--Y--C(M.sub.1)--A, or formula II, B--C.apprxeq.C--CH.sub.2 C(M.sub.2)--C.apprxeq.C--P--R.sub.5 --A: wherein Y is: ##STR1## wherein P is: ##STR2## Patentable intermediates, process for making the novel analogs and intermediates and preparation of useful pharmacological agents comprising the analogs and intermediates are part of this invention.Type: GrantFiled: June 29, 1989Date of Patent: May 26, 1992Assignee: The Upjohn CompanyInventor: Joel Morris
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Patent number: 5112857Abstract: This invention relates to compounds of formulae I and II ##STR1## which are metabolites of tetrahydrosimvastatin and 5-hydroxy-tetrahydrosimvastatin and which are HMG-CoA reductase inhibitors.Type: GrantFiled: September 4, 1990Date of Patent: May 12, 1992Assignee: Merck & Co., Inc.Inventor: Stanley Vickers
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Patent number: 5110602Abstract: The present invention relates to new pharmaceutical compositions characterizing that esters or amides are suspended or dissolved in a middle chain glyceride or a mixture thereof. These pharmaceutical compositions inhibit the degradation of the active ingredient (i.e. ester or amides) by the action of various digestive enzymes in digestive system.Type: GrantFiled: January 15, 1991Date of Patent: May 5, 1992Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Soonih Kim, Kazuhisa Takeda, Seiei Sasatani
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Patent number: 5098895Abstract: A benzonaphthalene compound has the formula ##STR1## wherein R.sub.1 represents ##STR2## or (ii) --CH.sub.2 OH; R.sub.6 represents ##STR3## or OR.sub.7 wherein R.sub.7 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl or polyhydroxyalkyl, r' or r" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl or a residue of an amino acid or a sugar, or together form a heterocycle; R.sub.2 represents hydrogen, alkyl having 1-15 carbon atoms, alkoxy having 1-4 carbon atoms or a cycloaliphatic radial; R.sub.3 represents hydrogen, hydroxy, alkyl having 1-4 carbon atoms, alkoxy having 1-10 carbon atoms, a cycloaliphatic radical, a thiocycloaliphatic radical or --O--Si(CH.sub.3).sub.2 --R.sub.8 wherein R.sub.8 represents lower alkyl; and R.sub.4 and R.sub.5 represent hydrogen, lower alkyl, hydroxy or lower acyloxy.This compound is useful in the topical and systemic treatment of dermatologic diseases and in the treatment of the degeneration of conjunctive tissues.Type: GrantFiled: March 30, 1990Date of Patent: March 24, 1992Assignee: Centre International de Recherches Dermatologiques (C.I.R.D.)Inventors: Braham Shroot, Jacques Eustache, Jean-Michel Bernardon
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Patent number: 5084482Abstract: This invention concerns novel methods employing compositions containing as an active antioxidant or antiinflammatory agent the amino acid methionine, and/or one or more related compounds including certain metabolic precursor compounds, for treating or inhibiting inflammatory ischemic, thrombotic and cholesterolemic disease response in a subject. The compounds include the methionine hydroxy analogs, as well as compounds having the structural formula I: ##STR1## and pharmaceutically acceptable N-(mono- and di-carboxylic acid) acyl derivatives and alkyl esters thereof, where n is an integer from 1 to 3.Type: GrantFiled: April 10, 1990Date of Patent: January 28, 1992Assignee: The Lithox CorporationInventors: Gerald P. Hirsch, Robert K. Bayless
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Patent number: 5061723Abstract: For treatment of acne the glucuronide of retinoic acid (retinoyl .beta.-glucuronide) is orally administered to women of child-bearing age who are capable of conception. This therapy is safer than the oral administration of retinoic acid because retinoic acid glucuronide is essentially non-teratogenic at dose levels effective for the acne treatment. The retinoic acid glucuronide can be in all-trans or 13-cis form.Type: GrantFiled: May 22, 1989Date of Patent: October 29, 1991Assignee: Iowa State University Research Foundation, Inc.Inventors: Arun B. Barua, Desiree Gunning, James A. Olson
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Patent number: 5053229Abstract: Novel cosmetic compositions comprising a lipid derived from horny cells can enhance a moisture retention ability of the horny layer and are useful for remedy of dry skin. When the lipid is used in combination with surface active agents, the above effect is enhanced.The cosmetic compositions may take any preparations such as creams, milky lotions, beauty wash, rouges, foundations, hair tonics and the like.Type: GrantFiled: January 24, 1989Date of Patent: October 1, 1991Assignee: Kao CorporationInventors: Michihiro Hattori, Shuichi Akazaki, Naonobu Yoshizuka, Genji Imokawa
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Patent number: 5051449Abstract: A method for retarding and reversing cellulite comprises topically applying to human skin a retinoid in an amount and for a period of time effective to retard or reverse cellulite where said amount is insufficient to be excessively irritating. The method preferably uses retinoic acid in an emollient vehicle.Type: GrantFiled: February 27, 1991Date of Patent: September 24, 1991Inventor: Albert M. Kligman
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Patent number: 5039513Abstract: Disclosed are topical compositions comprising sorbohydroxamic acid with a radical scavenging compound which prevent damage to skin caused UV radiation. Also disclosed is a method for using these compositions topically, to prevent damage to skin caused by UV radiation exposure.Type: GrantFiled: August 25, 1989Date of Patent: August 13, 1991Assignee: The Procter & Gamble CompanyInventors: Ranjit U. Chatterjee, Stephen J. Kirchner
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Patent number: 5025035Abstract: The instant invention is a novel use of known cyclic amino acids. Such compounds, including gabapentin, are useful for treating major and minor forms of depression.Type: GrantFiled: October 12, 1990Date of Patent: June 18, 1991Assignee: Warner-Lambert CompanyInventor: Jan D. Wallace
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Patent number: 5019569Abstract: The present invention is directed to the topical administration of a retinoid-containing pharmaceutical composition for reversing the effects of glucocorticoid-induced skin atrophy.Type: GrantFiled: August 31, 1989Date of Patent: May 28, 1991Assignee: Ortho Pharmaceutical CorporationInventors: Albert M. Kligman, James A. Mezick, Robert J. Capetola
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Patent number: 5001128Abstract: Disclosed are novel 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids and esters derived therefrom and pharmaceutically acceptable salts thereof.Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.Type: GrantFiled: December 15, 1989Date of Patent: March 19, 1991Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.Inventors: Kent W. Neuenschwander, Anthony C. Scotese
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Patent number: 4997852Abstract: The present invention describes a protocol for achieving a very high degree of anticarcinogenic (chemopreventive and chemotherapeutic) activity through the combination of low suboptimal doses of a D-glucarolactone-based dietary anticarcinogen with low suboptimal doses of a retinoid-based anticarcinogen. Synergism is obtained by this combination and these two anticarcinogens can be employed at dosages far below toxic levels and at dosages that are practical as a food supplement.Type: GrantFiled: November 13, 1989Date of Patent: March 5, 1991Assignee: Ohio State University Research FoundationInventors: John P. Minton, Thomas E. Webb, Hussein M. Abou-Issa
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Patent number: 4996234Abstract: Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof.Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.Type: GrantFiled: December 5, 1989Date of Patent: February 26, 1991Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.Inventors: John R. Regan, Kent W. Neuenschwander
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Patent number: 4994494Abstract: Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof.Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.Type: GrantFiled: December 14, 1989Date of Patent: February 19, 1991Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.Inventors: John R. Regan, Joseph G. Bruno, Kent W. Neuenschwander, Donald E. Kuhla
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Patent number: 4992469Abstract: A quinone derivative of the formula (I): ##STR1## in which A is a group of the formula (IV): ##STR2## or a group of the formula (V): ##STR3## in which X and Y are either the same as or different from each other and each are hydroxy, methoxy or hydrogen; and n is an integer of 1 to 5,is disclosed. The compound is useful as a medicament.Type: GrantFiled: May 29, 1985Date of Patent: February 12, 1991Assignees: Eisai Co., Ltd., Nagoya UniversityInventors: Takayuki Ozawa, Morimitsu Nishikimi, Hiroshi Suzuki, Yoshiharu Shimomura, Isao Yamatsu, Shinya Abe, Kouji Yamada, Tohru Fujimori, Takanobu Takamura
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Patent number: 4990533Abstract: Novel benzoic acid or benzoic acid ester derivatives, pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpetic neuralgia, inflammatory eye disorders, psoriasis, dental pain, and headaches, particularly vascular headache, such as migraine, cluster, mixed vascular syndromes, as well as nonvascular, tension headaches.Type: GrantFiled: November 10, 1986Date of Patent: February 5, 1991Assignee: Warner-Lambert Co.Inventors: Michael F. Rafferty, Graham Johnson
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Patent number: 4987151Abstract: The present invention provides a purified compound of the structure; ##STR1## wherein R may be palmitoyl or steroyl. The invention also provides compositions comprising an admixture of the foregoing palmitate and stearate esters.The invention also provides a compound of the structure: ##STR2## The invention further provides pharmaceutical compositions including the aforementioned compounds and compositions and methods of inhibiting the acyl CoA: cholesterol acyltransferase catalyzed conversion of cholesterol to cholesteryl esters.Type: GrantFiled: June 19, 1989Date of Patent: January 22, 1991Assignee: The Trustees of Columbia University in the City of New YorkInventor: Ira A. Tabas
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Patent number: 4980349Abstract: The invention relates to new compounds corresponding to formula I: ##STR1## in which: W represents C=O, CH.sub.2 or CHOH,Z represents ##STR2## R.sub.1 and R.sub.2 represent especially Cl or F, R, R' and R" represent especially H,X represents especially CH.sub.2,Y represents especially COOH,u and v are two integers ranging from 0 to 10,p and q take the value 0 or 1,n and m are two integers ranging 0 to 10 andt is 0 or 1the total number of carbon atoms in the chain ##STR3## ranging from 2 to 20, and to their physiologically acceptable salts obtained with organic or inorganic acids.These compounds are useful for preparing medicinal products which have, especially, anti-inflammatory properties.Type: GrantFiled: November 12, 1987Date of Patent: December 25, 1990Assignee: SANOFIInventors: Pierre Roger, Jean-Paul Fournier, Alain Martin, Jean Choay
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Patent number: 4980095Abstract: Novel benzoic acid or benzoic acid ester derivatives, pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpetic neuralgia, inflammatory eye disorders, psoriasis, dental pain, and headaches, particularly vascular headache, such as migraine, cluster, mixed vascular syndromes, as well as nonvascular, tension headaches.Type: GrantFiled: June 1, 1987Date of Patent: December 25, 1990Assignee: Warner-Lambert CompanyInventors: Michael F. Rafferty, Graham Johnson
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Patent number: 4966773Abstract: Topical ophthalmic compositions containing microfine particles of one or more retinoids are described. The compositions are useful in the treatment of dry eye syndrome and related ophthalmic surface disorders and as ocular lubricants. A method of treating dry eye syndrome and related ophthalmic surface disorders and a method of providing topical ocular lubrication using these compositions are also described.Type: GrantFiled: April 17, 1989Date of Patent: October 30, 1990Assignee: Alcon Laboratories, Inc.Inventors: Philip D. Gressel, Robert E. Roehrs, John L. Ubels, Henry F. Edelhauser
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Patent number: 4959383Abstract: Phenylsulfone alkenoic acids and derivatives thereof are provided which have the structure ##STR1## wherein Ar represents an aryl group including phenyl or naphthyl which may or may not include one or more substituents, X is COOR wherein R is hydrogen, alkali metal or lower alkyl or X is 5-tetrazolyl or ##STR2## wherein R' is lower alkyl or aryl; n is 2, 3 or 4 and m is 2, 3 or 4. These compounds are cardiovascular agents which exhibit thromboxane antagonist activity and thus are useful in the treatment of thrombotic and vasospastic disease.Type: GrantFiled: October 31, 1988Date of Patent: September 25, 1990Assignee: E. R. Squibb & Sons, Inc.Inventor: Steven E. Hall
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Patent number: 4954332Abstract: Disclosed are pharmaceutical compositions comprising tocopherol sorbate and an anti-inflammatory agent which are useful for topical application to prevent damage to skin caused by acute or chronic UV exposure. Combinations of tocopherol sorbate, an anti-inflammatory agent, and a sunscreen are also disclosed.Also disclosed is a method for using these compositions topically to prevent damage to skin caused by acute or chronic UV exposure.Type: GrantFiled: June 26, 1989Date of Patent: September 4, 1990Assignee: The Procter & Gamble CompanyInventors: Donald L. Bissett, Rodney D. Bush, Ranjit Chatterjee
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Patent number: 4950669Abstract: The growth rate of an animal is stimulated by administering to the animal a growth promoting amount of a compound of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5, which can be the same or different, are each selected from the group consisting of hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms and halogen; X is selected from carbonyl and a ketal group of the formula ##STR2## wherein R.sub.6 and R.sub.7, which can be the same or different, are each selected from hydrogen and alkyl having 1 to 3 carbon atoms; A is a linear or branched alkylene having from 1 to 8 carbon atoms; and R.sub.8 and R.sub.9, which can be the same or different, are each selected from the group consisting of hydrogen, alkyl having 1 to 4 carbon atoms, or 2-hydroxy-alkyl wherein the alkyl group has 2 to 4 carbon atoms, or R.sub.8 and R.sub.Type: GrantFiled: July 19, 1988Date of Patent: August 21, 1990Assignee: Cometec s.r.l.Inventors: Aldo Garzia, Umberto Bucci
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Patent number: 4945106Abstract: Prostaglandin analogues exhibiting activity at thromboxane receptor sites have been prepared.Type: GrantFiled: July 6, 1989Date of Patent: July 31, 1990Assignee: National Research Development CorporationInventors: Robert L. Jones, Norman H. Wilson
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Patent number: 4927850Abstract: This invention concerns novel dietary or therapeutic antioxidant compositions containing as the active agent the amino acid methionine, and/or one or more related compounds including certain metabolic precursor compounds, and novel methods employing the compositions for inhibiting inflammatory symptoms of respiratory disease. The compounds include the methionine hydroxy analog, the S-methyl methionine analog, and methionine compounds having the structural formula I ##STR1## and pharmaceutically acceptable N- (mono- and dicarboxylic acid) acyl derivatives and alkyl esters thereof, where n is an integer from 1 to 3.Type: GrantFiled: April 8, 1988Date of Patent: May 22, 1990Inventors: Robert K. Bayless, Gerald P. Hirsch
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Patent number: 4908384Abstract: Fatty acid compounds of the formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, A, Y and k are as defined herein are novel and useful in the treatment of allergic and inflammatory disorders.Type: GrantFiled: August 29, 1986Date of Patent: March 13, 1990Assignee: McNeilab, Inc.Inventors: Chih Y. Ho, Richard J. Mohrbacher
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Patent number: 4902709Abstract: Novel antihypercholesterolemic compounds of structure (I) or (II), ##STR1## pharmaceutically acceptable salts, thereof and a novel process for preparing compounds of structure I, are disclosed.Type: GrantFiled: August 12, 1988Date of Patent: February 20, 1990Assignee: Merck & Co., Inc.Inventor: Gerald E. Stokker
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Patent number: 4889847Abstract: The present invention is directed to the topical administration of a retinoid-containing pharmaceutical composition for the prevention of glucocorticoid-induced skin atrophy.Type: GrantFiled: November 3, 1986Date of Patent: December 26, 1989Assignee: Ortho Pharmaceutical CorporationInventors: Albert M. Kligman, James A. Mezick, Robert J. Capetola
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Patent number: 4877805Abstract: Various effects of photoaging or sundamage of skin including impairment of differentiation of epidermal epithelial cells and loss of collagen fibers, abnormal changes in elastic fibers and deterioration of small blood vessels in the dermis of the skin are retarded by applying topically to the epidermis in a maintenance therapy program effective amounts of retinoids including retinoid derivatives and stereoisomers thereof such that epithelial growths are substantially reduced and prevented and the skin substantially regains and maintains its firmness, turgor and elasticity. Moreover, with persistent treatment dermal blood cells and vessels increase and the epidermis and dermis thicken, resulting in improved ability of the skin to sense, resist and recover from irritation or injury. Further, hyperpigmentation, lines and wrinkles due to aging are reduced and prevented. The treatment is particularly useful for human facial skin and preferably applied in amounts insufficient to cause excessive irritation.Type: GrantFiled: June 3, 1988Date of Patent: October 31, 1989Inventor: Albert M. Kligman
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Patent number: RE34440Abstract: A benzonaphthalene compound has the formula ##STR1## wherein R.sub.1 represents ##STR2## or (ii) --CH.sub.2 OH; R.sub.6 represents ##STR3## or OR.sub.7 wherein R.sub.7 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl or polyhydroxyalkyl, r' or r" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl or a residue of an amino acid or a sugar, or together form a heterocycle; R.sub.2 represents hydrogen, alkyl having 1-15 carbon atoms, alkoxy having 1-4 carbon atoms or a cycloaliphatic radial; R.sub.3 represents hydrogen, hydroxy, alkyl having 1-4 carbon atoms, alkoxy having 1-10 carbon atoms, a cycloaliphatic radical, a thiocycloaliphatic radical or --O--Si(CH.sub.3).sub.2 --R.sub.8 wherein R.sub.8 represents lower alkyl; and R.sub.4 and R.sub.5 represent hydrogen, lower alkyl, hydroxy or lower acyloxy.This compound is useful in the topical and systemic treatment of dermatologic diseases and in the treatment of the degeneration of conjunctive tissues.Type: GrantFiled: July 16, 1992Date of Patent: November 9, 1993Assignee: Centre International de Recherches Dermatologiques (C.I.R.D.)Inventors: Braham Shroot, Jacques Eustache, Jean-Michel Bernardon