Heparin Or Derivative Patents (Class 514/56)
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Publication number: 20100075922Abstract: The invention relates to biotinylated heparins comprising constituent polysaccharides having at their reducing ends at least one covalent bond with biotin or a biotin derivative, and also to the process for preparing them, to pharmaceutical compositions containing them and to their therapeutic use. The biotinylated polysaccharides are of the formula (I) with the variables as defined herein.Type: ApplicationFiled: August 11, 2009Publication date: March 25, 2010Applicant: SANOFI-AVENTISInventors: Christian VISKOV, Philippe HUBERT, Pierre MOURIER
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Publication number: 20100074938Abstract: There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.Type: ApplicationFiled: September 15, 2009Publication date: March 25, 2010Inventors: Stefan Oscarson, Martina Lahmann, Karin Leontein, Robert Vestberg
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Publication number: 20100069326Abstract: The invention is compositions and methods for treating vascular disorders and/or conditions that involve administering a first agent comprising triflusal (or a triflusal analog or derivative) in combination with at least one other active agent.Type: ApplicationFiled: August 14, 2009Publication date: March 18, 2010Inventors: Wasimul Haque, Neil Dunwald
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Publication number: 20100062970Abstract: The present invention provides propyl phenoxy ether compounds and pharmaceutically acceptable salts thereof, compositions containing the same and one or more active agents, and methods of administering active agents with the same. The delivery agents of the present invention are well suited for forming non-covalent mixtures with active agents for oral, intracolonic, pulmonary, and other routes of administration to animals.Type: ApplicationFiled: August 16, 2007Publication date: March 11, 2010Applicant: Emisphere Technologies Inc.Inventor: Jianfeng Song
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Publication number: 20100055086Abstract: The present invention provides antimicrobial solutions that comprise at least one alcohol, at least one antimicrobial agent and at least one chelator and/or anticoagulant. Also provided are methods for rapidly reducing a microbe or a virus from surfaces including surfaces of indwelling medical devices and organic surfaces such as skin and sutures, and inorganic surfaces such as hospital equipment, pipelines etc.Type: ApplicationFiled: September 15, 2009Publication date: March 4, 2010Inventor: Issam Raad
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Publication number: 20100041587Abstract: The invention features methods for preventing platelet activation and aggregation and for treating individuals suffering from conditions or undergoing procedures that may result in unwanted platelet aggregation. The methods are based on the intravenous, subcutaneous, or transdermal administration of a platelet activation or aggregation inhibitor, e.g., xemilofiban, followed by oral administration of the same or a different platelet activation or aggregation inhibitor. The treatment may commence prior to a medical or surgical procedure or after the outbreak of an adverse medical condition, either of which results in the activation of platelets that may lead to thrombus formation, and may continue thereafter.Type: ApplicationFiled: August 12, 2009Publication date: February 18, 2010Inventors: R. Stephen PORTER, Kristen K. Flaharty, James E. Tcheng, John W. Ferkany
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Publication number: 20100040662Abstract: Fixation devices for tissue repair, for example sutures, surgical arrows, staples, darts, bolts, screws, buttons, anchors, nails, rivets, or barbed devices comprise at least one of angiogenic material; angiogenic precursor material which is capable of breaking down in vivo to form angiogenic material; or tissue-engineered material, which tissue-engineered material is capable of producing angiogenic material. In a preferred form, the material is incorporated into a polymer matrix having predetermined hydrophobicity to allow controlled release of angiogenic materials such as butyric or hydroxybutyric acid or salts thereof. Polymer matrix compositions comprising angiogenic materials and methods for tissue repair are also provided.Type: ApplicationFiled: June 15, 2009Publication date: February 18, 2010Inventors: Nicholas J. Cotton, Emma J. Wright, Steven W. Astorino, Saad Ali
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Publication number: 20100028421Abstract: The invention relates to a solid oral dosage form comprising a pharmaceutically active ingredient in combination with an enhancer which enhances the bioavailability and/or the absorption of the active ingredient. Accordingly, a solid oral dosage form comprises a drug and an enhancer wherein the enhancer is a medium chain fatty acid ester, ether or salt or a derivative of a medium chain fatty acid, which is, preferably, solid at room temperature and which has a carbon chain length of from 6 to 20 carbon atoms. Preferably, the solid oral dosage form is controlled release dosage form such as a delayed release dosage form.Type: ApplicationFiled: September 3, 2009Publication date: February 4, 2010Inventors: Kenneth I. Cumming, Zebunnissa Ramtoola
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Patent number: 7655445Abstract: The present invention provides methods, processes and reaction mixtures, which produce sulfated heparosan polysaccharides. This invention also provides methods and reaction mixtures for the synthesis of N-deacetylate N-sulfate derivatives of non-sulfated N-acetyl heparosan (HS) polysaccharides.Type: GrantFiled: November 12, 2004Date of Patent: February 2, 2010Assignee: Massachusetts Institute of TechnologyInventors: Robert D. Rosenberg, Kuberan Balagurunathan
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Publication number: 20100021538Abstract: An oral pharmaceutical composition for anticoagulation of blood includes a conjugate of an anticoagulation polysaccharide, such as heparin, covalently bonded to a hydrophobic agent wherein the conjugate is mixed with a solubilizer for inhibiting self-aggregation of the conjugate into nanoparticles. The composition can be coated, formed into tablets, or placed in capsules. Methods of making these oral formulations are also described.Type: ApplicationFiled: March 30, 2009Publication date: January 28, 2010Inventors: Youngro Byun, Jinwoo Park, Ok-Cheol Jeon, Hyun Tae Moon
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Publication number: 20100022473Abstract: This invention provides for the use of compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothing or a spacer group ranging in length from 2 to 30 atoms, X is a physiologically acceptable monomer, dimer, oligomer, or polymer, wherein X is a glycosaminoglycan; and n is a number from 2 to 1000, wherein any bond between L, Z, Y and X is either an amide or an esoteric bond in treating a subject suffering from a disease associated with harmful angiogenic processes such as cancer.Type: ApplicationFiled: March 18, 2009Publication date: January 28, 2010Inventor: Saul YEDGAR
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Publication number: 20100004198Abstract: Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide. In some embodiments, the incorporating step comprises 1) mixing the at least one inhibitor with the at least one polysaccharide at a highly hydrated state thereby encapsulating the at least one inhibitor in a polysaccharide network, and 2) dehydrating the polysaccharide network thereby controlling release kinetics or final swell ratio. In another embodiment, the incorporating step comprises 1) encapsulating at least one inhibitor into a biocompatible or biodegradable vessel and 2) combining the polysaccharide and the vessel into a gel formulation. The polysaccharide gel formulations described herein can be used for a variety of cosmetic applications.Type: ApplicationFiled: September 11, 2009Publication date: January 7, 2010Applicant: ALLERGAN, INC.Inventors: Dimitrios STROUMPOULIS, Christopher S. Mudd, Ahmet Tezel
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Publication number: 20100004199Abstract: The present invention provides pharmaceutical uses of betaines, and especially glycine betaine, such as for the treatment of thromboses not induced by hyperhomocystenemia or homocystinuria, of blood disorders, such as blood coagulation and thrombi formation.Type: ApplicationFiled: September 14, 2009Publication date: January 7, 2010Inventor: Jallal Messadek
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Publication number: 20090325876Abstract: This invention provides for the use of compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothing or a spacer group ranging in length from 2 to 30 atoms, X is a physiologically acceptable monomer, dimer, oligomer, or polymer, wherein X is a glycosaminoglycan; and n is a number from 2 to 1000, wherein any bond between L, Z, Y and X is either an amide or an esteric bond in treating a subject suffering from a disease associated with elevated level of a Matrix Metalloprotease (MMP) such as a malignant cancer.Type: ApplicationFiled: May 11, 2009Publication date: December 31, 2009Inventor: Saul Yedgar
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Publication number: 20090324540Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.Type: ApplicationFiled: June 10, 2009Publication date: December 31, 2009Applicant: Emisphere Technologies, Inc.Inventors: Donald J. Sarubbi, Eugene N. Barantsevitch
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Patent number: 7625552Abstract: According to an aspect of the present invention, bioactive polymers are provided which have (a) a hydrophilic bioactive portion and (b) at least one hydrophobic polymer group that is linked to the hydrophilic bioactive portion by a covalent linkage that contains a chain transfer agent residue. According to another aspect of the present invention, medical articles are provided with bioactive surface by coating them with a coating material that contains such bioactive polymers.Type: GrantFiled: May 30, 2006Date of Patent: December 1, 2009Assignee: Boston Scientific Scimed, Inc.Inventors: Michael N. Helmus, Paul Valint, Shrirang V. Ranade
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Publication number: 20090281059Abstract: A conjugate between an anti-thrombotic agent and bioabsorbable polymer is provided. Also, a method is provided for applying a coating comprising an anti-thrombotic agent and bioabsorbable polymer conjugate to at least some of an implantable device to prevent or reduce formation of thrombosis on the surface of the device. A first or sub-layer of the coating is prepared by mixing polymeric material and a biologically active agent with a solvent, thereby forming a homogeneous solution. A second or outer layer comprises an anti-thrombotic heparin-bioabsorbable polymer conjugate. This coating may be applied over inner drug-containing layers using, for example, dip coating or spray coating processes. After drying, the anti-thrombotic heparin bioabsorbable polymer conjugate remains in the outer layer of coating, allowing agent from the inner layer to elute there through. Also, the outmost layer prevents thrombosis, and can modulate release kinetics of agent(s) contained within inner layer(s) of the coating.Type: ApplicationFiled: July 20, 2009Publication date: November 12, 2009Inventors: Robert Falotico, Jonathon Z. Zhao
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Publication number: 20090274741Abstract: Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a polymeric product of a reaction comprising a polyol, a polycarboxylic acid, an amino acid and an agent.Type: ApplicationFiled: July 16, 2009Publication date: November 5, 2009Inventors: Stephen D. Pacetti, Charles D. Claude, Thierry Glauser, Jessica R. DesNoyer, Syed F.A. Hossainy
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Publication number: 20090270332Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with venous thrombosis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.Type: ApplicationFiled: March 13, 2009Publication date: October 29, 2009Applicant: CELERA CORPORATIONInventors: Lance BARE, James J. DEVLIN, Frits R. ROSENDAAL, Pieter H. REITSMA, Irene D. BEZEMER
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Publication number: 20090269385Abstract: Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing sugar cross-linked collagen matrices of different densities. The composite matrices may be used in bone regeneration and/or augmentation applications. Scaffolds including glycated and/or reducing sugar cross-linked collagen exhibit improved support for cell proliferation and/or growth and/or differentiation. The denser collagen matrix of the composite matrices may have a dual effect initially functioning as a cell barrier and later functioning as an ossification supporting layer. The composite matrices, implants and scaffolds may be prepared using different collagen types and collagen mixtures and by cross-linking the collagen(s) using a reducing sugar or a mixture of reducing sugars. The composite matrices, implants and scaffolds may include additives and/or living cells.Type: ApplicationFiled: April 30, 2009Publication date: October 29, 2009Inventors: Yuval ZUBERY, Arie GOLDLUST, Thomas BAYER, Eran NIR
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Publication number: 20090258055Abstract: A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.Type: ApplicationFiled: June 22, 2009Publication date: October 15, 2009Applicant: Abbotte Cardiovascular Systems Inc.Inventors: Syed Faiyaz Ahmed Hossainy, Ni Ding
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Publication number: 20090258054Abstract: A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.Type: ApplicationFiled: June 22, 2009Publication date: October 15, 2009Applicant: Abbotte Cardiovascular Systems Inc.Inventors: Syed Faiyaz Ahmed Hossainy, Ni Ding
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Patent number: 7598224Abstract: The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties separated by a first linker of from 3 to about 20 backbone atoms, which peptide chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a second linker, which may be a hydrophobic second linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.Type: GrantFiled: February 24, 2005Date of Patent: October 6, 2009Assignee: BioSurface Engineering Technologies, Inc.Inventors: Paul O. Zamora, Louis A. Pena, Xinhua Lin
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Publication number: 20090238852Abstract: Described herein are methods for controlling the intracellular calcium concentration in a subject prior to experiencing an ischemic event, while experiencing an ischemic event, or while suffering from ischemia. The methods comprise administering an effective amount of O-desulfated heparin to the subject. The methods described herein are also useful in treating the symptoms associated with ischemic events or ischemia.Type: ApplicationFiled: March 20, 2009Publication date: September 24, 2009Inventors: Thomas P. Kennedy, William H. Barry
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Patent number: 7585642Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.Type: GrantFiled: November 30, 2006Date of Patent: September 8, 2009Assignee: Massachusetts Institute of TechnologyInventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
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Publication number: 20090220606Abstract: This invention provides a method for inhibiting or preventing the abnormal growth of cells, including transformed cells, by administering an effective amount of O-acylated heparin derivative. Abnormal growth of cells refers to cell growth independent of normal regulatory mechanism (e.g. loss of contact inhibition). This includes the abnormal growth of: (1) tumor cells (tumors); (2) benign and malignant cells of other proliferative disease in which aberrant cellular proliferation occurs; (3) aberrant smooth muscle cell proliferation, such as might occur following treatment for coronary atherosclerosis such as angioplasty or the insertion of a stent into an occluded vessel.Type: ApplicationFiled: April 20, 2009Publication date: September 3, 2009Inventors: Charles A. Hales, Hari G. Garg, Lunyin Yu, Robert J. Linhardt
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Publication number: 20090214623Abstract: The invention relates to an anisotropic hydrogel and a method of producing the anisotropic hydrogel. The hydrogel exhibiting anisotropic properties is poly(vinyl alcohol) produced by preparing a solution of poly(vinyl alcohol) with a pre-selected concentration, thermally cycling the solution by freezing and thawing, stretching the hydrogel and thermally cycling the hydrogel at least one more time The anisotropic hydrogel is used for tissue replacement and reconstruction, bioagent entrapment and delivery, in preparing ultrasound or radiofrequency thermal therapy transmission pads and substitutes for ice bags, as denture base, in soft contact lens material, for wound covering bandages and phantoms for medical-related use.Type: ApplicationFiled: March 30, 2006Publication date: August 27, 2009Inventors: Wankei Wan, Leonardo E. Millon, Hadi Mohammadi
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Publication number: 20090216317Abstract: An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.Type: ApplicationFiled: March 22, 2006Publication date: August 27, 2009Inventors: Keith R. Cromack, John L. Toner, Sandra E. Burke, Richard W. Krasula, Lewis B. Schwartz
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Publication number: 20090214563Abstract: The present application provides compositions and methods for treating antiphospholipid-syndrome-related pregnancy complications with tissue factor antagonists.Type: ApplicationFiled: October 20, 2006Publication date: August 27, 2009Inventors: Daniel Kirchhofer, Jane E. Salmon, Guillermina Girardi
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Patent number: 7575886Abstract: The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.Type: GrantFiled: March 11, 2003Date of Patent: August 18, 2009Assignee: Momenta Pharmaceuticals, Inc.Inventors: Ganesh Venkataraman, Zachary Shriver, Malikarjun Sundaram, Yi-Wei Qi, Ram Sasisekharan
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Publication number: 20090202607Abstract: Heparin-like compounds inhibit collagen-induced platelet aggregation in flowing whole blood. The compounds share properties displayed by native mast-cell derived heparin proteoglycans (HEP-PG) and/or heparin glycosaminoglycan (HEP-GAG) molecules. The compounds are useful in prevention and treatment of severe vascular disorders including arterial thrombosis.Type: ApplicationFiled: February 13, 2009Publication date: August 13, 2009Applicant: JENNY JA ANTTI WIHURIN RAHASTOInventors: Riitta Lassila, Petri Kovanen, Ken Lindstedt
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Publication number: 20090202628Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.Type: ApplicationFiled: March 6, 2009Publication date: August 13, 2009Inventors: Hsing-Wen Sung, Mei-Chin Chen, Yu-Hsin Lin, Hsiang-Fa Liang, Hosheng Tu
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Publication number: 20090196928Abstract: Compositions, instruments, systems, and methods are providing for creating families of materials having diverse therapeutic indications and possessing enhanced biocompatibility. One genus platform for the families includes a biocompatible synthetic electrophilic component mixed with a nucleophilic component. The electrophilic component can include a functionalized electrophilic poly (anhydride ester) material. The nucleophilic material can include a natural, autologous protein. The components, when mixed in a liquid state, react by cross-linking, forming a solid matrix composition, or hydrogel.Type: ApplicationFiled: April 8, 2009Publication date: August 6, 2009Inventor: Olexander Hnojewyi
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Publication number: 20090191177Abstract: The present invention relates to enantiomerically pure (?) 2-[1-(7-methyl-2-(morpholin-4-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino]benzoic acid or pharmaceutically acceptable salts thereof, it being in a solid state, its use in medical therapy, pharmaceutical composition comprising it, its use in the preparation of a medicament for use in a method for preventing or treating diseases, and its use in method for preventing or treating disease. The present invention relates to a selective inhibitor of phosphoinositide (PI) 3-kinase ? and use of the selective inhibitor in e.g. anti-thrombotic therapy.Type: ApplicationFiled: January 25, 2009Publication date: July 30, 2009Inventors: Ola Fjellstrom, David Gustafsson, Jan A. Lindberg, Shaun Jackson
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Publication number: 20090191183Abstract: Disclosed herein are substituted indole cysteinyl leukotriene receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.Type: ApplicationFiled: July 29, 2008Publication date: July 30, 2009Applicant: AUSPEX PHARMACEUTICALS, INC.Inventors: Thomas G. Gant, Sepehr Sarshar
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Patent number: 7563762Abstract: The present invention relates in general to the field of biotechnology. The invention particularly relates to a composition and process for stabilizing or preserving biological molecules, as well as devices that comprise correspondingly stabilized or preserved biomolecules.Type: GrantFiled: July 4, 2003Date of Patent: July 21, 2009Assignee: Micronas GmbHInventor: Holger Klapproth
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Patent number: 7563780Abstract: A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.Type: GrantFiled: June 18, 2004Date of Patent: July 21, 2009Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed Faiyaz Ahmed Hossainy, Ni Ding
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Publication number: 20090181067Abstract: The present invention is directed to immobilized biologically active entities that retain significant biological activity following mechanical manipulation of a substrate material to which the entities are immobilized.Type: ApplicationFiled: March 24, 2009Publication date: July 16, 2009Inventors: Robert L. Cleek, Michael D. Daly, Krzysztof R. Pietrzak
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Publication number: 20090181927Abstract: Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.Type: ApplicationFiled: March 19, 2009Publication date: July 16, 2009Applicant: PhotoBioMed CorporationInventors: Ronald E. Utech, Kaia L. Kloster, Millard M. Judy, Kevin J. Vaska, James L. Matthews
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Publication number: 20090181066Abstract: The present invention is directed to immobilized biologically active entities that retain significant biological activity following mechanical manipulation of a substrate material to which the entities are immobilized.Type: ApplicationFiled: March 24, 2009Publication date: July 16, 2009Inventors: Robert L. Cleek, Michael D. Daly, Krzysztof R. Pietrzak
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Publication number: 20090181889Abstract: Disclosed herein are compositions and methods for detection and treatment of human herpesvirus (HHV)-6.Type: ApplicationFiled: March 7, 2007Publication date: July 16, 2009Applicant: UNIVERSITY OF ROCHESTERInventors: Stephen Dewhurst, Zhu Zhen, Birgit Bradel-Tretheway
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Patent number: 7560444Abstract: Formulation for pulmonary delivery of a therapeutic, prophylactic, or diagnostic agent including a low molecular weight heparin and a therapeutic, prophylactic, or diagnostic agent.Type: GrantFiled: October 1, 2004Date of Patent: July 14, 2009Assignee: Momenta Pharmaceuticals, Inc.Inventors: Thomas Richardson, Ganesh Venkataraman, Yiwei Qi, Michele Picard
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Publication number: 20090175928Abstract: The invention relates to a self-adhesive lip plaster which comprises at least one single-layered matrix and which contains at least one antiviral active medical substance for using in the event of Herpes labialis. Said matrix is arranged on a flexible carrier film which is hydrophobic and also permeable to vapor.Type: ApplicationFiled: October 9, 2006Publication date: July 9, 2009Inventors: Stephan Maier, Ulrike Vollmer
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Publication number: 20090169560Abstract: In the present invention there are disclosed new derivatives of dianhydrohexite mononitrate corresponding to formula (I), tautomers, pharmaceutically acceptable salts, prodrugs and solvates thereof: as well as pharmaceutical compositions comprising these compounds and uses thereof.Type: ApplicationFiled: March 9, 2009Publication date: July 2, 2009Applicant: LACER S.A.Inventors: Jose Repolles Moliner, Eduardo Salas Perez-Rasilla, Francisco Pubill Coy
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Patent number: 7553872Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.Type: GrantFiled: February 13, 2006Date of Patent: June 30, 2009Assignee: Emisphere Technologies, Inc.Inventors: Donald J. Sarubbi, Evgueni Barantsevitch
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Publication number: 20090162438Abstract: Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient's body including vascular lumens.Type: ApplicationFiled: December 19, 2008Publication date: June 25, 2009Inventors: Gerald G. Fuller, C. Travis Rappleye, Evgenia Mandrusov
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Patent number: 7550443Abstract: The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity that are able to release a bioactive agent, wherein the coatings are formed using biostable or biodegradable polymeric material and photoreactive groups.Type: GrantFiled: March 25, 2005Date of Patent: June 23, 2009Assignee: SurModics, Inc.Inventors: Sean M. Stucke, Ralph A. Chappa, Joseph A. Chinn
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Patent number: 7550444Abstract: The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some aspects, the biocompatible coatings of the invention are able to release a bioactive agent. The coatings can be formed using biostable or biodegradable polymeric material and photoreactive groups. The invention also provides methods for improving the quality of bioactive agent-containing coatings by performing pre-irradiation of biocompatible coating compositions.Type: GrantFiled: March 25, 2005Date of Patent: June 23, 2009Assignee: SurModics, Inc.Inventors: Sean M. Stucke, Ralph A. Chappa, Joseph A. Chinn, Aron B. Anderson
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Publication number: 20090149424Abstract: Heparin conjugates and methods of making and use thereof are disclosed. An illustrative heparin conjugate includes a composition wherein a bile acid is bonded to heparin through the 3-carbon of the bile acid. A spacer may be interposed between the bile acid and the heparin. Another embodiment includes a targeting moiety bonded to the heparin-bile acid conjugate through a spacer. Another illustrative heparin conjugate includes heparin covalently bonded to a sulfonated moiety, such as a naphthalene trisulfonate residue. A method of treating cancer includes administering a heparin conjugate to an individual in need thereof.Type: ApplicationFiled: August 7, 2008Publication date: June 11, 2009Applicant: MEDIPLEX CORPORATION, KOREAInventors: Youngro Byun, E. Sak Lee, Ok-cheol Jeon, Sang Yoon Kim, Rang-Woon Park
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Publication number: 20090149423Abstract: The present invention relates to the use of heparin oligosaccharides having a molecular weight?5050 Da and an anti-factor Xa activity?80 IU/mg, or their sodium salts, for preparing a medicament for the prevention and treatment of osteoporosis and associated pathologies and for preparing a medicament effective for the prevention and treatment of cerebral ischemia and pathologies related thereto whose treatment necessitates drugs able to cross the blood-brain barrier.Type: ApplicationFiled: October 27, 2005Publication date: June 11, 2009Applicant: OPOCRIN S.P.A.Inventors: Pietro Bianchini, Giuseppe Mascellani, Bruna Parma