Heparin Or Derivative Patents (Class 514/56)
  • THE ISOLATION AND CHARACTERISATION OF HEPARAN SULPHATES AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT AND STEM CELL CULTURE MEDIA SUITABLE FOR CONDITIONS ASSOCIATED WITH BONE REPAIR
    Publication number: 20120230964
    Abstract: Heparan sulphates isolated from male and female murine liver, their characterisation and use in pharmaceutical compositions, methods of treatment and in stem cell culture media suitable for conditions associated with bone repair.
    Type: Application
    Filed: November 19, 2010
    Publication date: September 13, 2012
    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Simon Cool, Victor Nurcombe, Murali Sadasivam
  • Method for finger-printing heparins
    Patent number: 8262881
    Abstract: Methods to generate a distinctive fingerprint (pattern of migration) for a sample of complex, polydisperse heparins are provided. The methods involve adding resolving agents such as polyamines to a heparin sample and then analyzing the sample with a technique that separates macromolecules according to charge to mass ratio (e.g. capillary electrophoresis). The resulting electropherogram is unique to and characteristic of the heparin sample. The methods may be used, for example, to monitor the quality and consistency of various heparin preparations.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: September 11, 2012
    Assignee: Virginia Commonwealth University
    Inventors: Umesh R. Desai, J. Timothy King
  • Use of Sulfated Glycosaminoglycans for Establishing Effective Labor in Women
    Publication number: 20120225843
    Abstract: A method of treating protracted labor in a pregnant woman comprises administering to a pregnant woman an effective amount of a depolymerised low molecular weight heparin treated with periodate to eradicate antithrombin III binding affinities, thereby exhibiting an anticoagulant activity of 10 BP units/mg or less and an average molecular weight not higher than 10000 Da to prime or curatively treat the cervix and myometrium and for treatment of slow progress of labor. A method for prophylactic priming or curative treatment of the cervix and the myometrium for establishing effective labor in a pregnant woman comprises administering to a pregnant woman an effective amount of a depolymerised low molecular weight heparin as described to prophylactically prime or curatively treat the cervix and myometrium and for establishing effective labor in the pregnant woman.
    Type: Application
    Filed: May 9, 2012
    Publication date: September 6, 2012
    Applicant: DILAFOR AB
    Inventors: Gunvor EKMAN-ORDEBERG, Anders MALMSTRÖM
  • Oral solid composition comprising a lipid absorption inhibitor
    Patent number: 8252312
    Abstract: The present invention provides an oral solid composition comprising a lipase inhibitor, an acid soluble polymer and an excipient. The composition may further comprise a second active. The composition may also further comprise a functional excipient.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: August 28, 2012
    Inventors: David Wong, Kate Wensie Wong, Spencer Wenyen Wong
  • Transdermal delivery system for therapeutics
    Publication number: 20120201857
    Abstract: The present invention provides a method and product for transdermal delivery of therapeutics, including neurotoxins and methods for use thereof. The method and system comprises pharmaceutical compositions for facilitating transdermal delivery of therapeutics without pain by absorption and more particularly a series of pharmaceutical formulations for topical administration of neurotoxins to humans, including a neurotoxin, such as a botulinum toxin, and absorption enhancing agents that facilitate absorption of the neurotoxin through the skin of the patient and do not eliminate the bioactivity associated with the neurotoxin. The pharmaceutical compositions are topically applied on a patient, and are generally in a cream or gel form.
    Type: Application
    Filed: March 17, 2010
    Publication date: August 9, 2012
    Inventor: Pankaj Modi
  • LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS
    Publication number: 20120201816
    Abstract: The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4??I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
    Type: Application
    Filed: April 12, 2012
    Publication date: August 9, 2012
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Donald J. P. Pinto, Mimi L. Quan, Michael J. Orwat, Yun-Long Li, Wei Han, Jennifer X. Qiao, Patrick Y. S. Lam, Stephanie L. Koch
  • COACERVATE HAVING AN IONIC POLYMER MIXED WITH THE ADHESIVE PROTEIN OF A MUSSEL OR OF A SPECIES OF THE VARIOME THEREOF
    Publication number: 20120201748
    Abstract: The present invention relates to a coacervate comprising a mussel adhesive protein and an anionic polymer, and more particularly, to a coacervate prepared by mixing a mussel adhesive protein with an anionic polymer, and a novel use thereof. In the present invention, a coacervate prepared by mixing a mussel adhesive protein and an anionic polymer shows a very excellent adhesive strength to various substrates such as cells or metals, and is able to maintain its adhesive strength in the presence of water or under water, thereby being effectively used as an adhesive. Moreover, it has an activity capable of encapsulating bioactive materials, thereby being effectively used as an active component of a composition for delivering bioactive materials.
    Type: Application
    Filed: August 6, 2010
    Publication date: August 9, 2012
    Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Hyung Joon Cha, Yoo Seong Choi, Dong Gyun Kang, Young Hoon Song, Seonghye Lim, Bong-Hyuk Choi
  • KITS AND IMPROVED COMPOSITIONS FOR TREATING LOWER URINARY TRACT DISORDERS
    Publication number: 20120196830
    Abstract: Superior buffered formulations and their kits for treating lower urinary tract symptoms and disorders are provided in the invention. In particular superior buffered formulations have demonstrated improvement for treating lower urinary tract symptoms of patients experiencing severe pain and/or urgency of the bladder and associated areas of the lower urinary tract.
    Type: Application
    Filed: April 9, 2012
    Publication date: August 2, 2012
    Inventor: C. Lowell Parsons
  • SENSITIZATION OF CANCER CELLS TO TREATMENT
    Publication number: 20120196828
    Abstract: The present application provides methods for the treatment of cancer, comprising administering substantially non-anticoagulant 2-O, 3-O desulfated heparin to patients suffering from cancer that is, or can become resistant to, cancer treatment, such as chemotherapy, targeted cancer therapy, or radiation therapy. The compositions can be administered to sensitize, or to reverse resistance to, cancer treatment, and can be administered alone or in combination with cancer treatment to subjects with solid tumors including, but not limited to, pancreatic, breast, renal, colorectal, gastric, or esophageal cancer, and subjects with hematologic malignancies, including but not limited to leukemia and lymphoma.
    Type: Application
    Filed: January 31, 2012
    Publication date: August 2, 2012
    Applicant: ParinGenix, Inc.
    Inventor: Stephen MARCUS
  • PHARMACEUTICAL FORMULATIONS CONTAINING MICROPARTICLES OR NANOPARTICLES OF A DELIVERY AGENT
    Publication number: 20120189666
    Abstract: This invention relates to microparticles and/or nanoparticles containing a delivery agent and/or an active agent. This invention also relates to pharmaceutical formulations and solid dosage forms, including controlled release solid dosage forms of active agent and a delivery agent.
    Type: Application
    Filed: November 23, 2011
    Publication date: July 26, 2012
    Applicant: Emisphere Technologies, Inc.
    Inventors: Nikhil Dhoot, Halina Levchik, Shingai Majuru, George Klein, Jamila Harris, Puchun Liu, Steven Dinh, Jun Liao, Jongbin Lee, Ehud Arbit, Nai Fang Wang
  • Pharmaceutical Dosage Forms for the Release of Active Compounds
    Publication number: 20120189698
    Abstract: Pharmaceutical form containing at least an active compound and a polymeric matrix, wherein said polymeric matrix comprises at least one polymer of cationic nature and at least one biodegradable polymer, process for the preparation thereof, pharmaceutical formulations comprising said pharmaceutical form, and their uses. The pharmaceutical form provides enhanced absorption of active compounds across the mucosa.
    Type: Application
    Filed: January 23, 2012
    Publication date: July 26, 2012
    Applicant: LABORATORIOS FARMACEUTICOS ROVI S.A.
    Inventors: Iván LÓPEZ-BELMONTE ENCINA, Ibon GUTIERRO ADURIZ, Philippe MAINCENT
  • METHODS FOR HEMATOPOIETIC PRECURSOR MOBILIZATION
    Publication number: 20120189574
    Abstract: Methods of modulating mobilization of cells from the bone marrow are provided. In a specific embodiment there is provided a method of increasing mobilization of hematopoietic precursors from the bone marrow to the peripheral blood in a subject in need thereof, the method comprising: (a) administering to the subject an agent which downregulates an activity or expression of a coagulation factor or an effector thereof; and (b) harvesting the hematopoietic precursors from the peripheral blood.
    Type: Application
    Filed: September 5, 2010
    Publication date: July 26, 2012
    Applicants: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Anna Aronovich, Dalit Tchorsh-Yutsis, Gideon Rechavi, Yair Reisner
  • Organic compounds
    Publication number: 20120190645
    Abstract: The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention also relates to methods for screening compounds and compositions useful for inhibiting or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.
    Type: Application
    Filed: April 6, 2012
    Publication date: July 26, 2012
    Inventors: Robert Blue, Barry S. Coller
  • Derivatives of partially desulphated glycosaminoglycans endowed with antiangiogenic activity and devoid of anticoagulating effect
    Patent number: 8222231
    Abstract: Partially desulfated glycosaminoglycan derivatives are described, particularly heparin, and more particularly formula (I) compounds where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives exhibit antiangiogenic activity and are devoid of anticoagulant activity.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: July 17, 2012
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite SpA
    Inventors: Benito Casu, Giangiacomo Torri, Anna Maria Naggi, Giuseppe Giannini, Claudio Pisano, Sergio Penco
  • DISSOLUTION AIDS FOR ORAL PEPTIDE DELIVERY COMPRISING A BIGUANIDE
    Publication number: 20120177602
    Abstract: A pharmaceutical composition comprising a mixture of: (c) an active macromolecular principle; (d) an aromatic alcohol absorption enhancer chosen from propyl gallate, butylated hydroxy toluene (BHT), butylated hydroxy anisole (BHA) and analogues and derivatives thereof, or mixtures thereof; and (d) a biguanide or a pharmaceutically acceptable salt thereof, capable of increasing the solubility of the aromatic alcohol absorption enhancer in an aqueous medium, wherein the aromatic alcohol absorption enhancer is present in an amount by weight greater than or equal to that of the active principle.
    Type: Application
    Filed: March 8, 2012
    Publication date: July 12, 2012
    Inventor: Roger R. C. NEW
  • Compositions and Methods for Inducing or Enhancing Connective Tissue Repair
    Publication number: 20120177600
    Abstract: A composition capable of attenuating platelet hyperactivation and associated methods for administering the same to a subject, the composition comprising an aqueous solution containing from about 0.1% to about 7.0% by weight of a glycosaminoglycan and from about 1.0% to about 32% by weight of a neutral polysaccharide.
    Type: Application
    Filed: September 21, 2010
    Publication date: July 12, 2012
    Inventors: Peter Byron Buckley, Konrad Messmer, Mark William Phillips
  • Dopamine 3 receptor agonist and antagonist treatment of gastrointestinal motility disorders
    Publication number: 20120164139
    Abstract: Provided herein are methods of treating gastrointestinal motility disorders by targeting the dopamine 3 receptor (D3R). A D3R agonist is administered to a subject to decrease gastrointestinal motility to treat the disorder. A D3R antagonist is administered to a subject to decrease gastrointestinal motility to treat the disorder.
    Type: Application
    Filed: March 6, 2012
    Publication date: June 28, 2012
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Pankaj Jay Pasricha, Maria-Adelaide Micci
  • Use of sulfated glycosaminoglycans for establishing effective labor in women
    Patent number: 8207145
    Abstract: The invention refers to the use of sulfated glycosaminoglycans having an anticoagulant activity of 100 BP units/mg or less for the manufacture of a pharmaceutical preparation for prophylactic priming or curative treatment of the cervix and the myometrium for establishing effective labor in women.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: June 26, 2012
    Assignee: Dilafor AB
    Inventors: Gunvor Ekman-Ordeberg, Anders Malmström
  • Stent fabrication via tubular casting processes
    Patent number: 8206635
    Abstract: Tubular casting processes, such as dip-coating, may be used to form substrates from polymeric solutions which may be used to fabricate implantable devices such as stents. The polymeric substrates may have multiple layers which retain the inherent properties of their starting materials and which are sufficiently ductile to prevent brittle fracture. Parameters such as the number of times the mandrel is immersed, the duration of time of each immersion within the solution, as well as the delay time between each immersion or the drying or curing time between dips and withdrawal rates of the mandrel from the solution may each be controlled to result in the desired mechanical characteristics. Additional post-processing may also be utilized to further increase strength of the substrate or to alter its shape.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: June 26, 2012
    Assignee: Amaranth Medical Pte.
    Inventors: Kamal Ramzipoor, Alfred N. K. Chia, Liwei Wang
  • Stent fabrication via tubular casting processes
    Patent number: 8206636
    Abstract: Tubular casting processes, such as dip-coating, may be used to form substrates from polymeric solutions which may be used to fabricate implantable devices such as stents. The polymeric substrates may have multiple layers which retain the inherent properties of their starting materials and which are sufficiently ductile to prevent brittle fracture. Parameters such as the number of times the mandrel is immersed, the duration of time of each immersion within the solution, as well as the delay time between each immersion or the drying or curing time between dips and withdrawal rates of the mandrel from the solution may each be controlled to result in the desired mechanical characteristics. Additional post-processing may also be utilized to further increase strength of the substrate or to alter its shape.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: June 26, 2012
    Assignee: Amaranth Medical Pte.
    Inventors: Kamal Ramzipoor, Alfred N. K. Chia, Liwei Wang, Chang Y. Lee
  • BICYCLIC AND TRICYCLIC DERIVATIVES AS THROMBIN RECEPTOR ANTAGONISTS
    Publication number: 20120157403
    Abstract: Heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein represents an optional double bond, the dotted line is optionally a bond or no bond, resulting in a double bond or a single bond, as permitted by the valency requirement and wherein E, A, G M, Het, B, X, R3, R10, R11, R32 and R33 are herein defined and the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.
    Type: Application
    Filed: February 24, 2012
    Publication date: June 21, 2012
    Inventors: Samuel Chackalamannil, Mariappan V. Chelliah, Yuguang Wang, Yan Xia
  • Composition containing biocompatible polymerization accelerator and polymerizable material
    Patent number: 8202833
    Abstract: The present invention provides method and materials for forming a polymeric matrix having improved biocompatible properties. A polymerization accelerator is provided that includes an N-vinyl group and a biocompatible functional group. The polymerization accelerator is particularly useful for the polymerization of macromers, which can be used to form biocompatible polymeric coatings on the surface of biological materials, such as cells and tissue.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: June 19, 2012
    Assignee: Surmodics, Inc.
    Inventors: Dale G. Swan, Stephen J. Chudzik, Ronald F. Ofstead
  • DIAGNOSTIC AND PROGNOSTIC ASSAY
    Publication number: 20120142632
    Abstract: The present disclosure relates generally to the field of diagnostic and prognostic assays for diseases and conditions of the systemic vasculature. The present disclosure teaches an assay for identifying such a disease or condition of the systemic vasculature as well as classifying and determining the state or stage of the disease or condition or the risk of developing the disease or condition. The assay enabled herein is also useful in the stratification of a subject with respect to a risk of developing various diseases and conditions of systemic vasculature. The assay taught herein is also capable of integration into pathology architecture to provide a diagnostic and reporting system.
    Type: Application
    Filed: August 4, 2011
    Publication date: June 7, 2012
    Applicant: ST. VINCENT'S INSTITUTE OF MEDICAL RESEARCH
    Inventor: DUNCAN JOHN CAMPBELL
  • Epimerized derivatives of K5 polysaccharide with a very high degree of sulfation
    Patent number: 8193166
    Abstract: A new method is described for the oversulfation of epiK5-N-sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically free of activity on the coagulation parameters and useful in the cosmetic or pharmaceutical field. Also described are new low molecular weight epiK5-N-sulfates useful as intermediates in the preparation of the corresponding LMW-epiK5-N,O-oversulfate-derivatives.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: June 5, 2012
    Assignee: Glycores 2000 S.r.l.
    Inventors: Pasqua Anna Oreste, Giorgio Zoppetti
  • Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
    Patent number: 8188045
    Abstract: Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: May 29, 2012
    Assignee: Dyax Corp.
    Inventors: Henry Blair, Thomas Beck, Robert C. Ladner
  • Vasoprotective and cardioprotective antidiabetic therapy
    Publication number: 20120121530
    Abstract: The present invention relates to certain DPP-4 inhibitors for treating and/or preventing oxidative stress, vascular stress and/or endothelial dysfunction as well as to the use of such DPP-4 inhibitors in treatment and/or prevention of diabetic or non-diabetic patients, including patient groups at risk of cardiovascular and/or renal disease.
    Type: Application
    Filed: November 14, 2011
    Publication date: May 17, 2012
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Thomas KLEIN, Andreas DAIBER, Odd-Eric JOHANSEN, Michael MARK, Sanjaykumar PATEL, Hans-Juergen WOERLE
  • ANTIMICROBIAL AGENT, METHOD OF PREPARING AN ANTIMICROBIAL AGENT AND ARTICLES COMPRISING THE SAME
    Publication number: 20120114724
    Abstract: The present disclosure is directed to method of preparing an antimicrobial agent comprising heating a dialdehyde polysaccharide. The method comprises subjecting a dialdehyde polysaccharide, such as a dialdehyde starch or a dialdehyde cellulose, to heating and/or sonication for a period of time. Also provided herein is an antimicrobial composition comprising the prepared dialdehyde polysaccharide. The antimicrobial composition is effective at killing microbial agents such as viruses and bacteria within a short period of time.
    Type: Application
    Filed: November 8, 2010
    Publication date: May 10, 2012
    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Ronald Howard Baney, Samuel Ralph Farrah, Le Song
  • USE OF AN ACYLATED OCTASACCHARIDE AS AN ANTITHROMBOTIC AGENT
    Publication number: 20120115809
    Abstract: The instant invention relates to the use of the octasaccharide of formula (I), wherein Ac represents an acetyl group: in its acid form or in the form of any of its pharmaceutically acceptable salts, for the treatment and prevention of thromboses.
    Type: Application
    Filed: November 3, 2011
    Publication date: May 10, 2012
    Applicant: SANOFI
    Inventors: Pierre MOURIER, Christian VISKOV
  • Methods for analyzing or processing a heparin sample
    Patent number: 8173384
    Abstract: The invention relates to methods and products for analyzing or processing a heparin sample. In one embodiment, the methods comprise contacting the sample with heparinase I, heparinase II and heparinase III, determining the amount of a signature component in the sample using a separation method, and making a determination about the sample based upon a comparison of the amount of the signature component in the sample to a reference database for a heparin.
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: May 8, 2012
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • SULFATED HEPTASACCHARIDE AND ITS USE AS AN ANTITHROMBOTIC AGENT
    Publication number: 20120108543
    Abstract: The instant invention relates to the heptasaccharide of formula (I): in its acid form or in the form of any one of its pharmaceutically acceptable salts, and to its process of preparation. The oligosaccharide of formula (I) is useful as an antithrombotic agent.
    Type: Application
    Filed: November 3, 2011
    Publication date: May 3, 2012
    Applicant: SANOFI
    Inventors: Pierre MOURIER, Christian VISKOV
  • SULFATED OCTASACCHARIDE AND ITS USE AS ANTITHROMBOTIC AGENT
    Publication number: 20120108542
    Abstract: The instant invention relates to the octasaccharide of formula (I): in its acid form or in the form of any one of its pharmaceutically acceptable salts, and to its process of preparation. The oligosaccharide of formula (I) is useful as an antithrombotic agent.
    Type: Application
    Filed: November 3, 2011
    Publication date: May 3, 2012
    Applicant: SANOFI
    Inventors: Pierre MOURIER, Christian VISKOV
  • ACYLATED 1,6-ANHYDRO DECASACCHARIDE AND ITS USE AS AN ANTITHROMBOTIC AGENT
    Publication number: 20120108541
    Abstract: The instant invention relates to the decasaccharide of formula (I), wherein Ac represents an acetyl group: in its acid form or in the form of any one of its pharmaceutically acceptable salts, and to its process of preparation. The oligosaccharide of formula (I) is useful as an antithrombotic agent.
    Type: Application
    Filed: November 3, 2011
    Publication date: May 3, 2012
    Applicant: SANOFI
    Inventors: Pierre MOURIER, Christian VISKOV
  • ACYLATED DECASACCHARIDES AND THEIR USE AS ANTITHROMBOTIC AGENTS
    Publication number: 20120108544
    Abstract: The instant invention relates to decasaccharides of formula (I): wherein Ac represents an acetyl group and R represents a group of formula —OH or —OSO3?, in their acid form or in the form of any one of their pharmaceutically acceptable salts, and to their process of preparation. The oligosaccharides of formula (I) are useful as antithrombotic agents.
    Type: Application
    Filed: November 3, 2011
    Publication date: May 3, 2012
    Applicant: SANOFI
    Inventors: Pierre MOURIER, Christian VISKOV
  • Composition and method for healing tissues
    Patent number: 8168599
    Abstract: The composition and method for healing tissues is a medicinal composition for facilitating the growth, protection and healing of tissues and cells in animals and humans. The composition is formulated as a either a powder, gel, paste, film, fluid injectable, rehydratable freeze-dried paste or sponge, sprayable solution, topically applied patch with adhesive and reservoir system, an intermediate for coatables such as films and bandages, a matrix for membranes, or as a matrix of flexible polymer(s), or delivered as either an orally ingestible liquid, tablet or capsule. The main ingredient of the formulated compositions is hydrolyzed collagen, which can be combined with polysulfated glycosaminoglycans, hyaluronic acid or salts thereof, or a glucosamine salt, and mixtures thereof. The composition may be formulated as an aqueous eye drop solution.
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: May 1, 2012
    Inventors: George D. Petito, Anita M. Petito
  • POLYMERIC MATERIAL
    Publication number: 20120100217
    Abstract: Disclosed herein is a polymeric material comprising a conductive polymer substantially homogeneously distributed within a hydrogel. Also disclosed are methods for making the polymeric material and uses for the polymeric material.
    Type: Application
    Filed: June 9, 2011
    Publication date: April 26, 2012
    Applicant: NEWSOUTH INNOVATIONS PTY LIMITED
    Inventors: Rylie Adelle GREEN, Laura Anne POOLE-WARREN, Sungchul BAEK, Penny Jo MARTENS
  • Dual chain synthetic heparin-binding growth factor analogs
    Patent number: 8163717
    Abstract: The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties separated by a first linker of from 3 to about 20 backbone atoms, which peptide chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a second linker, which may be a hydrophobic second linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.
    Type: Grant
    Filed: October 6, 2009
    Date of Patent: April 24, 2012
    Assignee: BioSurface Engineering Technologies, Inc.
    Inventors: Paul O. Zamora, Louis A. Pena, Xinhua Lin
  • BIOACTIVE COMPOSITION INCLUDING STABILIZED PROTEIN AND PROCESS FOR PRODUCING THE SAME
    Publication number: 20120093802
    Abstract: A bioactive composition includes a porous hydrogel matrix. At least one protein is immobilized in the porous hydrogel matrix forming a hydrogel protein composite that is stable in an organic solvent. A process for stabilizing a bioactive composition includes the steps of: forming hydrogel matrix pores around protein molecules and reducing a water content within the hydrogel matrix pores forming a hydrogel protein composite that is stable in an organic solvent.
    Type: Application
    Filed: October 13, 2010
    Publication date: April 19, 2012
    Applicant: Toyota Motor Engineering & Manufacturing North America, Inc.
    Inventors: Ping Wang, Songtao Wu, Hongfei Jia, Masahiko Ishii, Minjuan Zhang
  • MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE
    Publication number: 20120094932
    Abstract: The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6 and R8 are each independently a member selected from the group consisting of H, C1-6 alkyl and OH; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: each of L2 and L3 are independently selected from the group consisting of: and salts, hydrates, isomers, metabolites and prodrugs thereof.
    Type: Application
    Filed: December 21, 2011
    Publication date: April 19, 2012
    Applicant: Elixir Medical Corporation
    Inventors: John Yan, Xiaoxia Zheng, Vinayak D. Bhat
  • Heparan Sulphate
    Publication number: 20120087899
    Abstract: Heparan sulphate from bone marrow stroma is disclosed together with the use of heparan sulphate from bone marrow stroma in the differentiation and/or lineage commitment of stem cells.
    Type: Application
    Filed: October 6, 2011
    Publication date: April 12, 2012
    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Simon Cool, Victor Nurcombe
  • WOUND HEALING DEVICE
    Publication number: 20120089084
    Abstract: A plasma coating device for treating a wound comprises a plasma chamber having: one or more electrodes, a gas supply inlet, a plasma outlet exposed to ambient pressure, and an ignition system operatively connected to the electrodes for providing a non-thermal equilibrium plasma within the plasma chamber. An aerosol delivery system is operable to introduce a bioresorbable material as an aerosol into the plasma, to produce a coating on the wound surface.
    Type: Application
    Filed: June 15, 2010
    Publication date: April 12, 2012
    Inventors: Joe O'Keeffe, Peter Dobbyn, John O'Donoghus, Liam O'Neil
  • [4-(6-HALO-7-Substituted-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREAS and Forms and Methods Related Thereto
    Publication number: 20120088736
    Abstract: The present invention provides novel sulfonylurea compounds of formula (I) and pharmaceutically acceptable derivatives and polymorph and amorphous forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or forms thereof.
    Type: Application
    Filed: October 11, 2011
    Publication date: April 12, 2012
    Applicant: Portola Pharmaceuticals, Inc.
    Inventors: Robert Scarborough, Carroll Anna Crew Scarborough, Wolin Huang, Mukund Mehrotra, Xiaoming Zhang, Hilary Cannon, Craig M. Grant
  • Protein biomaterials and biocoacervates and methods of making and using thereof
    Patent number: 8153591
    Abstract: The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention relates to protein biocoacervates and biomaterials that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, coated medical devices (e.g. stents, valves . . . ), vessels, tubular grafts, vascular grafts, wound healing devices including protein suture biomaterials and biomeshes, dental plugs and implants, skin/bone/tissue grafts, tissue fillers, protein biomaterial adhesion prevention barriers, cell scaffolding and other biocompatible biocoacervate or biomaterial devices.
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: April 10, 2012
    Assignee: Gel-Del Technologies, Inc.
    Inventors: David B. Masters, Eric P. Berg
  • Heparin coating of biological tissue
    Patent number: 8153147
    Abstract: The present invention discloses an in vitro method to provide biological tissue with a heparin coating comprising the following steps; linking a biotin reagent to biological tissue, linking an avidin reagent to the biotinylated biological tissue, and linking a heparin reagent to the formed layer of avidin on the biological tissue thus forming a heparin coating. The invention further discloses a heparin coating on biological tissue, the use of a heparin coating, and the biological tissue coated with a heparin layer according to the method.
    Type: Grant
    Filed: June 28, 2006
    Date of Patent: April 10, 2012
    Assignee: Corline Systems AB
    Inventor: Rolf Larsson
  • LIPID CONJUGATES IN THE TREATMENT OF ALLERGIC RHINITIS
    Publication number: 20120083466
    Abstract: Provided herein are methods of treating, suppressing, inhibiting, or preventing allergic rhinitis in a subject comprising the step of administering to a subject a compound comprising a lipid or phospholipid moiety bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof.
    Type: Application
    Filed: December 12, 2011
    Publication date: April 5, 2012
    Inventor: Saul YEDGAR
  • METHOD FOR BLOCKING LIGATION OF THE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS (RAGE)
    Publication number: 20120083465
    Abstract: A method and medicament is provided for treating and inhibiting interaction of the receptor for advanced glycation end-products (RAGE) and its ligands using a natural or synthetic sulfated polysaccharide, preferably a 2-O desulfated heparin. The medicament preferably is administered intravenously, by aerosolization, intra-nasally, intra-articularly, intra-thecally, subcutaneously, topically or orally. The medicament is useful for treating a variety of conditions, including diabetes, inflammation, renal failure, aging, systemic amyloidosis, Alzheimer's disease, inflammatory arthritis, atherosclerosis, and colitis.
    Type: Application
    Filed: April 1, 2011
    Publication date: April 5, 2012
    Applicant: University of Utah Research Foundation
    Inventor: Thomas P. Kennedy
  • IN VIVO BIOREACTORS AND METHODS OF MAKING AND USING SAME
    Publication number: 20120078229
    Abstract: The present invention relates to an in vivo method of promoting the growth of autologous cartilage and bone tissue, including tissue that can be explanted to other locations in the subject.
    Type: Application
    Filed: December 2, 2011
    Publication date: March 29, 2012
    Inventors: Pieter J. Emans, Prasad Venkatram Shastri
  • USE OF A COMPOSITION FOR THE TREATMENT OF MUCOSITIS
    Publication number: 20120077773
    Abstract: A composition having an ionic complex of chitosan and a negatively charged polysaccharide, selected from the group consisting of heparin, heparan sulfate and dextran sulfate, for use in the treatment of mucositis in a mammalian subject, to a method of preventing or treating mucositis in a mammalian subject, by applying topically a composition having an ionic complex of chitosan and a negatively charged polysaccharide, selected from the group consisting of heparin, heparan sulfate and dextran sulfate. The composition further relates to a pharmaceutical composition for topical administration of an ionic complex of chitosan and heparin.
    Type: Application
    Filed: June 10, 2010
    Publication date: March 29, 2012
    Applicant: EXTHERA AB
    Inventors: Lars Adolfsson, Olle Larm, Anders Westermark
  • Multi-Functional Biocompatible Coatings for Intravascular Devices
    Publication number: 20120070483
    Abstract: A polymeric coating is adapted to substantially eliminate thrombus formation when in contact with blood. The polymeric coating includes a first polymeric layer and a second polymeric layer. Interposed between the first and second polymeric layers is a polymeric matrix layer doped with at least one of a nitric oxide donor and a nitric oxide generator. The nitric oxide donor and/or the nitric oxide generator are capable of releasing or generating NO. A bioactive agent is either immobilized to the surface of the second polymeric layer or is incorporated into the polymeric matrix layer.
    Type: Application
    Filed: April 25, 2011
    Publication date: March 22, 2012
    Inventors: Zhengrong Zhou, Mark E. Meyerhoff, Melissa M. Reynolds
  • ADMINISTRATION OF ENOXOPARIN SODIUM TO PATIENTS 75 YEARS AND OLDER WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
    Publication number: 20120070471
    Abstract: Methods for treating ST-segment elevation myocardial infarction in a human patient 75 years of age or older. The methods comprise administering a dose of less than 1 mg per kg body weight, about 0.75 mg per kg of body weight, or 0.75 mg per kg of body weight of enoxaparin sodium by subcutaneous injection approximately every twelve hours for a therapeutic dosing period. The methods may include fibrinolytic therapy. The treatment methods may be used to prevent one or more of, mortality, myocardial re-infarction, myocardial ischemia, stroke, or severe congestive heart failure. Articles of manufacture for use in connection with treating ST-segment elevation myocardial infarction in a human patient 75 years of age or older are also disclosed.
    Type: Application
    Filed: September 23, 2011
    Publication date: March 22, 2012
    Inventors: Ger-Jan C.M. SANDERINK, Santosh Vetticaden, Hans Peter Bacher
  • METHOD OF TREATING THROMBOCYTOPENIA
    Publication number: 20120052055
    Abstract: Invented is a method of treating thrombocytopenia in a human, in need thereof which comprises the in vivo administration of a therapeutically effective amount of a peptide or a non-peptide TPO receptor agonist and an anti-clotting agent or agents, and optional further active ingredients, to such human.
    Type: Application
    Filed: May 6, 2010
    Publication date: March 1, 2012
    Applicant: Glaxosmithkline LLC
    Inventors: Connie L. Erickson-Miller, Michael Arning