Halogen Bonded Directly To Carbon In R Patents (Class 514/628)
  • Publication number: 20150023868
    Abstract: The present invention is directed to HIF inhibitors and methods of preventing cell proliferation, reducing inflammation, and treating an angiogenic disease or disorders.
    Type: Application
    Filed: February 21, 2014
    Publication date: January 22, 2015
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Othon Iliopoulos, Michael Zimmer
  • Publication number: 20140356439
    Abstract: Lipidated micro- or macroparticles are prepared by covalently linking a glycoprotein, typically collagen, with at least one lipid. An amino group in the glycoprotein is joined with a primary amine in the lipid. These particles can be used to encapsulate active ingredients, such as drugs.
    Type: Application
    Filed: August 14, 2014
    Publication date: December 4, 2014
    Inventors: Rimona MARGALIT, Dan PEER
  • Publication number: 20140323579
    Abstract: The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide, polymorphic forms thereof, methods for preparation and use thereof, pharmaceutical compositions thereof, and kits and articles of manufacture thereof.
    Type: Application
    Filed: April 24, 2014
    Publication date: October 30, 2014
    Inventors: Ahmad Y. Sheikh, Alessandra Mattei, Xiu C. Wang
  • Publication number: 20140220099
    Abstract: The present invention relates to a poly (ester amide) (PEA) having a chemical formula described by structural formula (IV), wherein m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9 m+p+q=1 whereby m or p could be 0 n is about 5 to about 300; (pref. 50-200) R1 is independently selected from the group consisting of (C2-C20) alkylene, (C2-C20) alkenylene, —(R9—CO—O—R10—O—CO—R9)—, —CHR11—O—CO—R12—COOCR11— and combinations thereof; R3 and R4 in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, (C1-C6)alkyl, —(CH2)SH, —(CH2)2S(CH3), —CH2OH, —CH(OH)CH3, —(CH2)4NH3+, —(CH2)3NHC(?NH2+)NH2, —CH2COOH, —(CH2)COOH, —CH2—CO—NH2, —CH2CH2—CO—NH2, —CH2CH2COOH, CH3—CH2—CH(CH3)—, (CH3)2—CH—CH2—, H2N—(CH2)4—, Ph-CH2—, CH?C—CH2—, HO-p-Ph-CH2—, (CH3)2—CH—, Ph-NH—, NH—(CH2)3—C—, NH—CH?N—CH?C—CH2—.
    Type: Application
    Filed: June 25, 2012
    Publication date: August 7, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Guy Draaisma, George Mihov
  • Patent number: 8759402
    Abstract: Methods of treating or inhibiting ischemia and reperfusion injury are provided.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: June 24, 2014
    Assignee: Radical Therapeutix
    Inventors: Roberta Gottlieb, Paul Wentworth, Eric F. Johnson, Mark J Yeager, David Granville
  • Publication number: 20140128335
    Abstract: The present invention relates to the use of polyaminoisoprenyl derivatives in antibiotic or antiseptic treatment of bacteria including those presenting multiple drug resistance (MDR), in particular as efflux pump inhibitors. It also relates to novel polyaminoisoprenyl derivatives, compositions comprising the same, process for preparing the same, and use thereof in antibiotic or antiseptic treatment.
    Type: Application
    Filed: February 23, 2012
    Publication date: May 8, 2014
    Applicants: UNIVERSITE D'AIX-MARSEILLE, UNIVERSITE DE CORSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jean-Michel Bolla, Jean Michel Brunel, Joseph Pierre Felix Casanova, Vannina Lorenzi, Liliane Berti
  • Patent number: 8680154
    Abstract: Injectable veterinary composition comprising a fluorinated chloramphenicol or thiamphenicol derivative and a solvent system comprising an ether of 1,2-ethanediol oligo- or polymers, and a pyrrolidone solvent.
    Type: Grant
    Filed: December 20, 2005
    Date of Patent: March 25, 2014
    Assignee: Intervet International B.V.
    Inventor: Carole Barbot
  • Publication number: 20130324481
    Abstract: This invention provides for biocompatible, biodegradable eye drop pharmaceutical formulations useful for the treatment of ocular indications. In particular, tocopherols and their esters of low water solubility, notably ?-tocopheryl acetate, are exceptional vehicles for biocompatible, nonirritating topical eye drop formulations that provide sustained release of active agents.
    Type: Application
    Filed: August 9, 2013
    Publication date: December 5, 2013
    Applicant: Ramscor, Inc.
    Inventors: Vernon G. Wong, Louis L. Wood
  • Publication number: 20130231276
    Abstract: Bacterial multidrug resistance is attenuated in a subject by administering an aminoacyl-tRNA synthetase inhibitor and an antibacterial agent to the subject, wherein the aminoacyl-tRNA synthetase inhibitor is distinct from the antibacterial agent.
    Type: Application
    Filed: April 12, 2013
    Publication date: September 5, 2013
    Applicant: Brown University
    Inventors: Jason K. Sello, James J. Vecchione
  • Publication number: 20130209537
    Abstract: The present invention relates to the preparation and use of antibiotic-containing nanoparticles for coating an implant including cranial implants and bone graft sites to provide for the extended release of antibiotics to treat infection.
    Type: Application
    Filed: July 1, 2011
    Publication date: August 15, 2013
    Inventor: Patty Fu-Giles
  • Publication number: 20130203857
    Abstract: The present invention is related to pharmaceutical compositions capable of inhibiting or eliminating an infectious process caused by bacteria in warm-blooded animals. The present invention describes a stable formulation with a minimized methylpyrrolidone concentration. In order to reduce N-methylpyrrolidone concentration, a mixture was developed that eliminates the need to add preservatives and exhibiting a suitable viscosity and ensures the solubility of the composition when administered in drinking water at a ratio of dilution of up to 5,000 times in chlorinated or non-chlorinated water.
    Type: Application
    Filed: January 19, 2011
    Publication date: August 8, 2013
    Applicant: Nanocore Biotecnologia S.A.
    Inventors: José Maciel Rodrigues, JR., Karla de Melo Lima
  • Publication number: 20130203858
    Abstract: The present invention relates to solid pharmaceutical compositions that dissolve readily and stably and which are capable of inhibiting or eliminating an infectious process caused by bacteria in warm-blooded animals and aquatic species such as, for example, fish and crustaceans. The invention describes composition for formulations containing antibiotics to be administered by various routes for treating bacterial infections in warm-blooded animals and aquatic animals. The formulation can be intended for human and animal use.
    Type: Application
    Filed: March 1, 2011
    Publication date: August 8, 2013
    Applicant: Nanocore Biotecnologia S.A.
    Inventors: José Maciel Rodrigues, Karla de Melo Lima
  • Publication number: 20130184279
    Abstract: Compounds of formula Ia and Ib wherein A, B, C, R1 and R14 are described herein.
    Type: Application
    Filed: December 18, 2012
    Publication date: July 18, 2013
    Applicant: Bristol-Myers Squibb Company
    Inventor: Bristol-Myers Squibb Company
  • Publication number: 20130165368
    Abstract: A composition for use in the prevention and/or treatment of microbial infection comprising essentially of one or more pure alkanol alkoxylates, diol alkoxylates and/or triol alkoxylates.
    Type: Application
    Filed: February 1, 2011
    Publication date: June 27, 2013
    Inventors: Ian Steel, Paul Armstrong
  • Publication number: 20130156816
    Abstract: The invention features compositions, methods, and kits for the administration of an oxidatively transformed carotenoid, or a fractionated component thereof, for use in aquaculture.
    Type: Application
    Filed: February 18, 2011
    Publication date: June 20, 2013
    Applicant: Chemaphor Inc.
    Inventors: Larry Arthur Stobbs, James Gary Nickerson, Clayton Paul Dick
  • Patent number: 8445534
    Abstract: This invention provides methods for treatment and inhibition of a male subject having an Androgen Decline in Aging Male (ADAM)-associated condition, for example sexual dysfunction, decreased sexual libido, erectile dysfunction, hypogonadism, sarcopenia, osteopenia, osteoporosis, an alteration in cognition and mood, depression, anemia, hair loss, obesity, muscle loss, dry eye, memory loss, benign prostate hyperplasia and/or prostate cancer, by administering to the subject a selective androgen receptor modulator (SARM) compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, pro-drug, polymorph, crystal, or any combination thereof.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: May 21, 2013
    Assignee: University of Tennessee Research Foundation
    Inventors: James T. Dalton, Duane D. Miller, Donghua Yin, Yali He
  • Publication number: 20130072565
    Abstract: The present invention relates generally to a method for stimulating cell proliferation. More specifically this invention discloses the use of increased cell proliferation in treatment of certain wounds.
    Type: Application
    Filed: September 20, 2012
    Publication date: March 21, 2013
    Inventors: Jan G. Smith, Mattias Andrup
  • Publication number: 20130059862
    Abstract: The invention provides a series of novel 1,2-disubstituted amido-anthraquinone derivatives. Further, the invention also provides the preparation method and application of said derivatives, said application comprises: said derivatives with therapeutically effective amount are prepared into pharmaceutical compositions for inhibition of cancer cell growth, further treating cancer.
    Type: Application
    Filed: August 1, 2012
    Publication date: March 7, 2013
    Inventor: Hsu-Shan HUANG
  • Publication number: 20130053342
    Abstract: The invention relates to the cosmetic use, as a skin moisturizer, of a compound of formula (I): with (i) R1 and R2 represent a hydrogen atom or a C1-C6 alkyl group, or (ii) R1 and R2 can form, together with the nitrogen atom which bears them, a saturated heterocycle with 5 to 7 ring members; R5 representing a hydrogen atom or a (C1-C3) alkyl group; R6 representing a hydrogen atom or a (C1-C4) alkyl group; R3 represents a hydrogen atom or a (C1-C6) alkyl group, or —OR3 represents a phosphate group; it being possible for the two groups R3 to form, together, an isopropylidene group; R4 represents a hydrogen atom or —OR4 represents a phosphate group; and the salts, solvates and isomers thereof. The invention also relates to a cosmetic composition comprising a compound (I) and the corresponding new compounds.
    Type: Application
    Filed: October 23, 2012
    Publication date: February 28, 2013
    Applicant: L'OREAL
    Inventor: L'OREAL
  • Publication number: 20130045265
    Abstract: The invention discussed is a durable Antimicrobial Strap made using a polymer material, including plastics or vinyl, or a combination thereof, which have been enhanced through the integration of antimicrobial material adapted to kill microbes. The Antimicrobial Strap may be used in applications including but not limited to gait belts, helmet harness, and seat belts in child safety seats where the strap controls the level of cross-contamination by killing unwanted microbes that contact the strap and thereby, prevents the spread of disease and infections.
    Type: Application
    Filed: August 15, 2012
    Publication date: February 21, 2013
    Inventor: Barry Glenn Chapman
  • Publication number: 20130028896
    Abstract: Provided are methods, uses and pharmaceutical compositions for treatment of prostate cancer with a SEMA3C inhibitor in a biologically effective amount sufficient to cause cell death of a prostate cancer cell or to inhibit proliferation of the prostate cancer cells. The prostate cancer may be an androgen receptor (AR) positive prostate cancer and the SEMA3C inhibitor may be selected from one or more of the following: an antibody, a SEMA3C peptide, an antisense RNA, a siRNA, a shRNA or a small molecule.
    Type: Application
    Filed: April 1, 2010
    Publication date: January 31, 2013
    Inventors: Christopher J. Ong, Martin E. Gleave, Norihiro Hayashi, James Peacock
  • Publication number: 20130022661
    Abstract: A bio-remodable augmentation device including an implantable member configured for maintaining space in a bone defect. The implantable member is formed from a bio-remodable composite having structural properties so as to aid in the generation of new bone tissue and eventually be reabsorbed in the newly formed bone tissue. This structural and bio-remodable implant reduces, if not eliminates, the need to remove the implantable member from the patient once new bone tissue is formed. A kit including the implantable devices and bone growth material is disclosed. Methods of use are also disclosed.
    Type: Application
    Filed: July 21, 2011
    Publication date: January 24, 2013
    Applicant: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Publication number: 20130004651
    Abstract: The present invention relates to the preparation of therapeutic compositions including drug-containing nanoparticles for coating a body implant to provide for drug delivery in a locally applied and extended release manner and their methods of use to treat physiological conditions.
    Type: Application
    Filed: July 27, 2012
    Publication date: January 3, 2013
    Inventor: Patty Fu-Giles
  • Publication number: 20120316106
    Abstract: Improved antibiotic analogs, and synergistic combinations of antibiotics designed based on structural crystallographic analysis, are provided as well as pharmaceutical compositions that include these improved analogs and synergistic combinations, along with methods for their production and use. The synergistic combinations target neighboring sites in the ribosome demonstrating the importance of the corresponding ribosomal sites for development of clinically-relevant synergistic antibiotics.
    Type: Application
    Filed: December 29, 2010
    Publication date: December 13, 2012
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Ada Yonath, Chen Davidovich, Ella Zimmerman, Anat Bashan, Tamar Auerbach, Matthew Belousoff, Liqun Xiong, Dorota Klepacki, Alexander S. Mankin
  • Publication number: 20120316234
    Abstract: The present invention is related to an anthraquinone-based compound represented by compound (I) wherein the R1, R2, R3, R4, R5 or R6 is selected by the group of H, amide, amino-amide, acyl, chloroacetamide, chloropropionamido, a substituted chloroacetamide and a substituted chloropropionamido. The present invention is also related to the method of producing the anthraquinone-based compound and the application thereof.
    Type: Application
    Filed: October 7, 2011
    Publication date: December 13, 2012
    Applicant: NATIONAL DEFENSE MEDICAL CENTER
    Inventor: Hsu-Shan HUANG
  • Publication number: 20120277178
    Abstract: Compositions and methods of treatment or prophylaxis of fragile-X associated disorders are provided, as well as methods of screening compounds and kits to screen a library of compounds.
    Type: Application
    Filed: April 27, 2012
    Publication date: November 1, 2012
    Applicant: EMORY UNIVERSITY
    Inventors: Peng JIN, Abrar QURASHI
  • Publication number: 20120245107
    Abstract: The invention relates to formulations of an antimicrobial agent, a lipid, and optionally a surfactant, and uses thereof for reducing the proliferation and viability of microbial agents.
    Type: Application
    Filed: June 7, 2012
    Publication date: September 27, 2012
    Inventors: William Henry, Henk-Andre Kroon, Linda Summerton
  • Publication number: 20120201901
    Abstract: A biocompatible putty formulation suitable for insertion within chronic and acute wounds of humans and animals, the formulation containing a topical antibiotic, a biocompatible humectant, a biocompatible viscosity-building agent, and at least 5% water, by weight, the humectant and the viscosity-building agent intimately mixed within the formulation, the formulation adapted whereby the formulation remains a solid over the entire temperature range of 20° C. to 35° C.
    Type: Application
    Filed: February 6, 2011
    Publication date: August 9, 2012
    Applicant: AIDANCE SKINCARE & TOPICAL SOLUTIONS, LLC
    Inventors: Perry Antelman, David Goldsmith, Shalom Lampert
  • Patent number: 8202875
    Abstract: The present invention relates to the use of selective insecticidal compositions, characterized in that they comprise an effective amount of an active compound combination comprising (a) at least one compound of the formula (I) in which CKE, W, X, Y and Z are as defined in the description, and (b) at least one crop plant compatibility-improving compound, from the group of compounds mentioned in the description, for controlling insects and/or arachnids, and to a method for controlling insects and/or arachnids using the compositions.
    Type: Grant
    Filed: July 18, 2005
    Date of Patent: June 19, 2012
    Assignee: Bayer Cropscience AG
    Inventors: Reiner Fischer, Udo Reckmann, Christopher Hugh Rosinger, Erich Sanwald, Christian Arnold
  • Publication number: 20120148690
    Abstract: A novel skin barrier function recovery acceleration method and accelerator are provided. The present invention provides a skin barrier function recovery accelerator that comprises a TRPA1 agonist capable of activating TRPA1 in epidermal cells.
    Type: Application
    Filed: December 10, 2010
    Publication date: June 14, 2012
    Inventors: Mitsuhiro Denda, Moe Tsutsumi, Sumiko Denda
  • Publication number: 20120149678
    Abstract: The invention provides organonitro compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat non-Hodgkin's lymphoma and certain leukemias in a patient. The compounds, compositions, kits, and methods are contemplated to provide a therapeutic benefit in treating non-Hodgkin's lymphoma, chronic lymphocytic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, and acute lymphoblastic leukemia. Exemplary organonitro compounds described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.
    Type: Application
    Filed: December 9, 2011
    Publication date: June 14, 2012
    Inventors: Bryan T. Oronsky, Susan Knox, Jan Scicinski, Shoucheng Ning
  • Publication number: 20120122938
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Application
    Filed: November 8, 2011
    Publication date: May 17, 2012
    Applicant: Acucela Inc.
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas Little, Anna Gall, Feng Hong
  • Patent number: 8158829
    Abstract: There is provided an organic sulfur compound having an excellent controlling effect on harmful arthropods which is represented by formula (I): wherein R1 represents a C3-C6 haloalkyl group having at least one fluorine atom and at least one atom selected from group consisting of a chlorine atom, a bromine atom and an iodine atom, R2 represents a cyano group and the like, R3 represents a hydrogen atom, a halogen atom or a C1-C4 alkyl group, R4 represents a C1-C5 fluoroalkyl group, and n represents 0, 1 or 2.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: April 17, 2012
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Hiroyuki Miyazaki
  • Publication number: 20120070369
    Abstract: The present invention is directed to HIF inhibitors and methods of preventing cell proliferation, reducing inflammation, and treating an angiogenic disease or disorders.
    Type: Application
    Filed: December 10, 2009
    Publication date: March 22, 2012
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Othon Iliopoulos, Michael Zimmer
  • Publication number: 20120064140
    Abstract: Composite nanogranules from polymer/inorganic nanoparticle, especially first composite nanogranules which are formed from first polymer and inorganic nanoparticles, second composite nanogranules which are obtained by forming second polymer on the first composite nanogranules, third composite nanogranules which is obtained by forming third polymer on the second composite nanogranules, and Nth composite nanogranules which is obtained by forming Nth polymer on the (N?1)th composite nanogranules with the similar method, are disclosed. A composition comprising anyone of the composite nanogranules described above is disclosed. The preparation method thereof and use of the same are also disclosed.
    Type: Application
    Filed: May 12, 2010
    Publication date: March 15, 2012
    Applicant: Wuxi Now Materials Corp.
    Inventors: Suping Qian, Yuhong Xu, Zhentian Fan, Yongtal Hou
  • Publication number: 20120064145
    Abstract: The present invention discloses a wound dressing which may be a double-layer wound dressing, comprising a polymer material layer in combination with anti-infective antibiotics or anti-infective Chinese herb medicine at the upper layer of the wound dressing, and a porous carbon material layer capable of loading with skin-associated epithelial cells at the lower layer of the wound dressing. The wound dressing with the antibiotics can block effectively the invasion of bacteria in the external environment, thereby preventing the wound from secondary infection. While covering the wound site, the porous carbon material layer with the epithelial cells can thus provide the healthy epithelial cells and attract the surrounding healthy cells to aggregate for secreting collagen so as to promote the wound healing process. According to the present invention, there is an obviously enhancing effect on wound tissue regeneration, restoration and healing, and there is a grant development potential in clinical applications.
    Type: Application
    Filed: January 27, 2011
    Publication date: March 15, 2012
    Applicant: CHINA MEDICAL UNIVERSITY
    Inventors: YU-SHIN LIN, CHIA-LIN YEH
  • Publication number: 20120039909
    Abstract: The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished through the increase of histone acetylation.
    Type: Application
    Filed: October 24, 2011
    Publication date: February 16, 2012
    Applicants: The General Hospital Corporation d/b/a Massachusetts General Hospital, Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Li-Huei Tsai, Andre Fischer, Stephen Haggarty, Weiping Tang, Stuart L. Schreiber
  • Publication number: 20110301127
    Abstract: The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of screening for inhibitors of AcrAB-like efflux pumps, and methods of enhancing antimicrobial activity of drugs are provided. Pharmaceutical composition comprising an inhibitor of an AcrAB-like efflux pump and an antimicrobial agent are also provided.
    Type: Application
    Filed: August 16, 2011
    Publication date: December 8, 2011
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: Margret OETHINGER, Stuart B. LEVY
  • Publication number: 20110287083
    Abstract: Bioabsorbable compositions of A) blends of bioabsorbable homopolymers and/or copolymers containing glycolide and lactide and B) salts of fatty acids and/or fatty acid esters are described. Processes for making the compositions and surgical articles made totally or in part therefrom, including suture coatings, are also described.
    Type: Application
    Filed: July 21, 2011
    Publication date: November 24, 2011
    Applicant: Tyco Healthcare Group LP
    Inventor: Ahmad R. Hadba
  • Publication number: 20110281809
    Abstract: Methods for treating and preventing otitis externa with a course of treatment consisting of as little as a single dose are provided. The methods are practiced by topical administration of compositions having a lipid carrier, such as liposomes and non-vesicular lipids, to the outer ear canal. Such compositions lack viscocity-enhancing celluloses or adhesives, and are preferably not in the form of a gel. Active agents useful for treating pain, inflammation, fungal or parasitic infestation and/or infections in the outer ear are co-administered in or with the composition.
    Type: Application
    Filed: November 10, 2010
    Publication date: November 17, 2011
    Applicant: Triad Specialty Products LLC
    Inventors: William R. Campbell, Neil E. Paulsen, Roland H. Johnson, Douglas I. Hepler
  • Patent number: 8017656
    Abstract: A compound given by the formula (I): has an excellent controlling activity against noxious arthropods.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: September 13, 2011
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Hiroyuki Miyazaki
  • Publication number: 20110207739
    Abstract: A series of novel 1,2-disubstituted amido-anthraquinone derivatives, and the preparation method and application of said derivatives. Said application includes said derivatives with therapeutically effective amount being prepared into pharmaceutical compositions for inhibition of cancer cell growth, further treating cancer.
    Type: Application
    Filed: February 25, 2010
    Publication date: August 25, 2011
    Inventor: Hsu-Shan HUANG
  • Patent number: 7994224
    Abstract: An aerosol paint composition includes an alkyd resin; one or more solvents; an organoclay; an anti-settling wax; a dispersing agent; one or more pigments; a drying agent; an anti-skinning agent; a fragrance; and a fungicide.
    Type: Grant
    Filed: July 5, 2006
    Date of Patent: August 9, 2011
    Assignee: Chase Products Co.
    Inventor: John D. Wyers
  • Patent number: 7947852
    Abstract: Compounds of formula (I): wherein: R1 represents alkyl, alkenyl, haloalkyl, polyhaloalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, X represents a group N—OR2 wherein R2 represents a hydrogen atom or an alkyl group. Medicinal products containing the same which are useful in treating disorders of the melatoninergic system.
    Type: Grant
    Filed: July 1, 2008
    Date of Patent: May 24, 2011
    Assignee: Les Laboratoires Servier
    Inventors: Said Yous, Mohamed Ettaoussi, Ahmed Sabaouni, Pascal Berthelot, Michael Spedding, Philippe Delagrange, Daniel-Henri Caignard, Mark Millan
  • Publication number: 20110091387
    Abstract: The RhoE GTPase pathway has been identified as a target for screening and treatment methods for the prevention and/or reduction of short- and long-term UVB-induced skin damage, e.g., the prevention and/or reduction of UVB-induced wrinkles. The invention thus features screening and treatment methods for prevention or reduction of UVB-induced sin damage, and related compositions, e.g., cosmetic compositions.
    Type: Application
    Filed: November 17, 2008
    Publication date: April 21, 2011
    Applicants: THE GENERAL HOSPITAL CORPORATION, SHISEIDO CO., LTD.
    Inventors: Sam W. Lee, Lakshmi Raj, Anna I. Mandinova, Haruhi Iwaki, Yuji Katsuta, Jotaro Nakanishi
  • Publication number: 20110086100
    Abstract: A polyethylene glycol (PEG) aerogel particles having an average particle diameter not substantially above about 2?, a volumetric porosity of greater than about 50%, and pore sizes capable of retaining drug molecules. A method for preparing such polyethylene glycol (PEG) aerogel particles includes initiating a catalyzed reaction using a catalyst of PEG forming ingredients to form PEG particles; partially drying the formed PEG particles under conditions to control pore size; and subjecting the partially dried formed PEG particles to CO2 supercritical extraction for form the PEG aerogel particles. Drug molecules include chemotherapeutic agents. The surface of the PEG aerogel particles are reactable with a variety of agents, for example, to selectively target tumors, protects irreversible damage to labile proteins, and protects degradation of sensitive drugs with subsequent loss of biological efficacy.
    Type: Application
    Filed: October 12, 2010
    Publication date: April 14, 2011
    Inventor: Yosry A. Attia
  • Publication number: 20110027377
    Abstract: A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classification System, wherein said drug (i) constitutes from above about 20% to 50% by weight of the composition, said pharmaceutical or veterinary granule composition providing a drug release of at least 70% within 10 minutes in water, (ii) a first excipient being a maltodextrin representing from 40% by weight to 85% by weight of said composition, (iii) a wetting amount of a second excipient being a polyethylene glycol having a weight number molecular weight between 300 and 5,000, said second excipient comprising a solid fraction and a liquid fraction, and representing from 15% to 40% by weight of said composition, and optionally one or more pharma-ceutically acceptable fillers selected from the group consisting of hydrocolloids, glidants, lubricants, surfactants and diluents, wherein the weight ratio of said first excipien
    Type: Application
    Filed: June 15, 2010
    Publication date: February 3, 2011
    Applicant: Universiteit Gent
    Inventors: Jean Paul Remon, Chris Vervaet
  • Publication number: 20110021448
    Abstract: Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.
    Type: Application
    Filed: December 4, 2009
    Publication date: January 27, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: BRUCE D. HAMMOCK, IN-HAE KIM, CHRISTOPHE MORISSEAU, TAKAHO WATANABE, JOHN W. NEWMAN
  • Publication number: 20110008454
    Abstract: A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classification System, wherein said drug (i) constitutes from 0.
    Type: Application
    Filed: June 15, 2010
    Publication date: January 13, 2011
    Applicant: Universiteit Gent
    Inventors: Jean Paul Remon, Chris Vervaet
  • Publication number: 20110009351
    Abstract: The present invention relates to a novel assay or screen for identifying compounds with potential therapeutic value for the treatment of protein trafficking diseases such as Cystic Fibrosis (CF) and nephrogenic diabetes insipidus (NDI). The usual approach involves expressing the mutant form of the gene in cells and assaying function in a multiwell format when cells are exposed to libraries of compounds. Although such functional assays are useful, they do not directly test the ability of a compound to correct defective trafficking of the protein. To address this a novel corrector screening assay for CF has been developed in which the appearance of the mutant protein at the cell surface is measured as the assay output. This assay was used to screen more than 3100 compounds. This novel screening approach to protein trafficking diseases is robust and general, and may enable the selection of molecules that can be translated rapidly to a clinical setting.
    Type: Application
    Filed: May 9, 2008
    Publication date: January 13, 2011
    Inventors: David Y. Thomas, John Hanrahan, Graeme Carlile, Renaud Robert