Benzene Ring Containing Patents (Class 514/699)
  • Patent number: 10252949
    Abstract: The invention relates to a novel aqueous suspension preparation comprising a water-suspended microparticulate calcite mineral with a particle diameter ?35 ?m, plant extract, and a surfactant that can shift the zeta potential of the water-suspended microparticulate calcite mineral into the negative range, and the use of this aqueous suspension preparation as a foliar fertilizer. The invention also relates to a foliar fertilizer comprising this aqueous suspension preparation.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: April 9, 2019
    Assignee: Agrosolution GmbH & Co. KG
    Inventors: Peter Huemer-Hartl, Franz Knauseder
  • Patent number: 9580379
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as compositions, methods for their use for treating disorders, mediated at least in part, by xanthine oxidase.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: February 28, 2017
    Assignee: BAYLOR COLLEGE OF MEDICINE
    Inventors: Changyi Chen, Qizhi Yao, Jian-Ming Lu
  • Patent number: 9044404
    Abstract: A method for the modification of melanin distribution, and the composition thereof to modify melanin distribution are disclosed. A method for the reduction of melanin distribution, and the composition thereof to reduce melanin distribution are disclosed. A representative composition comprises 4-ethoxybenzaldehyde and one or more additional active agents as well as a pharmaceutically acceptable carrier or excipient. Carriers and excipients may be formulated for topical administration. Compositions may also be formulated for transdermal administration. The compositions may be used for the prevention and treatment of pigmentation disorders, by way of non-limited example, post-inflammatory hyperpigmentation and others. The compositions may be used for lightening skin.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: June 2, 2015
    Assignee: Allergan, Inc.
    Inventors: Rahul C. Mehta, Elizabeth Tsin Ho Makino, Sujatha D. Sonti, John A. Garruto
  • Patent number: 9011829
    Abstract: Perfume compositions comprise between 10% and 30% in total weight of perfume ingredients selected from two groups, Group A, Group B, with the provisos that over 5% but less than 15% of the perfume composition must comprise Group A ingredients, and for compositions comprising less than 10% of Group A ingredients in the aggregate percentage of Group B ingredients present must be at least equal to the expression (2*/10?A %) where A % is the total percentage of Group A ingredients in the composition.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: April 21, 2015
    Assignee: Givaudan Nederland Services B.V.
    Inventors: Keith Douglas Perring, Michael Gordon Evans, Alan Forbes Provan, David Jonathan Bradshaw, John Martin Behan
  • Patent number: 8987337
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: March 24, 2015
    Assignee: Baylor College of Medicine
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20150051294
    Abstract: The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau.
    Type: Application
    Filed: April 8, 2013
    Publication date: February 19, 2015
    Applicant: Universtiy of South Florida
    Inventors: Chad Dickey, Umesh Jinwal, Laurent Calcul, Bill J. Baker
  • Publication number: 20150005389
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Application
    Filed: September 10, 2014
    Publication date: January 1, 2015
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20140378552
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Application
    Filed: September 10, 2014
    Publication date: December 25, 2014
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20140378478
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Application
    Filed: September 10, 2014
    Publication date: December 25, 2014
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Patent number: 8916611
    Abstract: The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: December 23, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Josee Roy, Susan J. Drapeau, Jeffrey C. Marx
  • Publication number: 20140364391
    Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.
    Type: Application
    Filed: June 6, 2014
    Publication date: December 11, 2014
    Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SA, NORTHWESTERN UNIVERSITY
    Inventors: Ton That Hai, John-Bruce Devault Green, Timothy Michael Fulghum, Phillip Byron Messersmith, Tadas Stanislovas Sileika
  • Publication number: 20140364508
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Application
    Filed: July 23, 2014
    Publication date: December 11, 2014
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20140363395
    Abstract: Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.
    Type: Application
    Filed: July 24, 2014
    Publication date: December 11, 2014
    Inventors: Theodore J. Nitz, Janet A. Gaboury, Christopher J. Burns, Sylvie Laquerre, Daniel C. Pevear, Thomas A. Lessen, David J. Rys
  • Patent number: 8895626
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: November 25, 2014
    Assignee: Baylor College of Medicine
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20140336204
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Application
    Filed: July 23, 2014
    Publication date: November 13, 2014
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20140336205
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Application
    Filed: July 23, 2014
    Publication date: November 13, 2014
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Patent number: 8883857
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: November 11, 2014
    Assignee: Baylor College of Medicine
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Patent number: 8883858
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: November 11, 2014
    Assignee: Baylor College of Medicine
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20140329909
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Application
    Filed: July 23, 2014
    Publication date: November 6, 2014
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20140301964
    Abstract: A composition is described that may be used in personal care products. The composition can serve as a preservative. In addition or alternatively, the composition may serve as a fragrance and/or as a coloring agent. The composition can contain an active compound, an organic acid, a solvent, and optionally a dispersant. In one embodiment, the active compound and the organic acid comprise all natural ingredients.
    Type: Application
    Filed: April 9, 2014
    Publication date: October 9, 2014
    Applicant: Arch Chemicals, Inc.
    Inventors: Diana Ciccognani, Falen D. Lockett, Laura Szymczak
  • Publication number: 20140271537
    Abstract: The present invention generally relates to deuterium-enriched aldehydes, compositions comprising deuterium-enriched aldehydes, and methods for slowing the rate of aldehyde autoxidation. In one aspect, the present invention provides a composition comprising a compound of structure 1: wherein: there are at least 6×1018 molecules of the aldehyde and Rx is hydrogen, wherein the deuterium isotope in Rx is in an amount greater than 0.10 percent of the hydrogen atoms present in Rx.
    Type: Application
    Filed: March 15, 2014
    Publication date: September 18, 2014
    Inventor: Anthony W. Czarnik
  • Publication number: 20140249192
    Abstract: The present invention provides compounds, that are N-alkyl-2-(1-(5-substituted-2-(3-oxo-3-(trifluoromethylsulfonamido)propyl)benzyl)pyrrolidin-2-yl)oxazole-4-carboxamide wherein the 5 substituent is selected from the group consisting of halo and alkyloxy radicals. The compound may be represented by the following formula wherein R1 is selected from the group consisting of CO2R7 and CON(R7)SO2R7 wherein R1, R2, R3, R4, and R7 are as defined in the specification. The compounds may be administered to treat DP1, FP, EP1, EP3, TP and/or EP4 receptor mediated diseases or conditions.
    Type: Application
    Filed: February 12, 2014
    Publication date: September 4, 2014
    Applicant: Allergan, Inc.
    Inventors: Jose L. Martos, William R. Carling, David F. Woodward, Jenny W. Wang, Jussi J. Kangasmetsa
  • Publication number: 20140242138
    Abstract: Method for the preparation of microencapsulated essential oils or a formulation thereof for various non-agricultural applications.
    Type: Application
    Filed: May 7, 2014
    Publication date: August 28, 2014
    Applicant: BOTANOCAP LTD.
    Inventors: Amnon Kritzman, Arie Markus, Pnina Strongin, Charles Linder
  • Publication number: 20140243421
    Abstract: A composition for controlling pests. The composition includes an aqueous mixture of at least one phenolic aldehyde and a bisulfite salt with a suitable surfactant and a sufficient amount of the bisulfite salt to solubilize the aldehyde(s). A stable apparent solution is formed.
    Type: Application
    Filed: May 1, 2014
    Publication date: August 28, 2014
    Inventor: Yoram Tsivion
  • Publication number: 20140220109
    Abstract: A process for producing a small-sized, lipid-based cochleates. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.
    Type: Application
    Filed: December 31, 2013
    Publication date: August 7, 2014
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Leila Zarif, Tuo Jin, Ignacio Segarra, Raphael J. Mannino
  • Publication number: 20140221384
    Abstract: The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.
    Type: Application
    Filed: April 7, 2014
    Publication date: August 7, 2014
    Applicant: ERIMOS PHARMACEUTICALS LLC
    Inventors: Jonathan Daniel Heller, Qingqi Chen, Rocio Alejandra Lopez, Amanda Jean Morris
  • Publication number: 20140163045
    Abstract: Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
    Type: Application
    Filed: March 8, 2013
    Publication date: June 12, 2014
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventors: Changyi Chen, Jian-Ming Lu, Qizhi Yao
  • Publication number: 20140080832
    Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.
    Type: Application
    Filed: November 13, 2013
    Publication date: March 20, 2014
    Applicant: MANNKIND CORPORATION
    Inventors: John Bruce PATTERSON, David Gregory LONERGAN, Gary A. FLYNN, Qingping ZENG, Peter V. PALLAI
  • Publication number: 20140065082
    Abstract: A white, color-stable anti-aging emulsion formula containing CoQ10 and/or vanillin. The amount of vanillin can be adjusted to provide light or dark tanning of the skin. Lime oil and lime juice form a preferred emulsion foundation.
    Type: Application
    Filed: September 5, 2012
    Publication date: March 6, 2014
    Inventor: Louise Holyfield
  • Publication number: 20130338224
    Abstract: The invention concerns a decontaminating composition having simultaneously bactericidal, fungicidal and virocidal properties, comprising as active components eugenol, eugenol acetate, vanillin and carvacrol, characterized in that said active constituents are present in the following percentages by weight: at least about 12% eugenol, at least about 3% eugenol acetate, at least about 0.1% vanillin and at least about 0.5% carvacrol. Said decontaminating composition can be used as liquid or solid soaps. It can also impregnate in liquid form fabrics and nonwoven fabrics such as garments for medical use, bed sheets, slip covers, surgery drape, dressings and gauze such as those applied to the skin of serious burn victims.
    Type: Application
    Filed: August 7, 2013
    Publication date: December 19, 2013
    Applicant: HIGHTECH BIO-ACTIVITIES HOLDING GMBH
    Inventors: Hakima BELBACHIR, Jean ANGELIDIS
  • Publication number: 20130330387
    Abstract: Antimicrobial lubricant compositions are disclosed. The antimicrobial lubricant compositions are particularly useful in providing antimicrobial capability to a wide-range of medical devices. The compositions include an oil lubricant. Representative lubricants may include polydimethyl siloxane, trifluoropropyl copolymer polysiloxane, and a copolymer of dimethylsiloxane and trifluoropropylmethylsiloxane. The compositions include rheology modifiers as necessary. The compositions also include antimicrobial agents, which may be selected from a wide array of agents. Representative antimicrobial agents include of aldehydes, anilides, biguanides, bis-phenols, quaternary ammonium compounds, cetyl pyridium chloride, cetrimide, alexidine, chlorhexidine diacetate, benzalkonium chloride, and o-phthalaldehyde.
    Type: Application
    Filed: April 22, 2013
    Publication date: December 12, 2013
    Applicant: Becton, Dickinson and Company
    Inventor: Becton, Dickinson and Company
  • Publication number: 20130303572
    Abstract: Compounds of general formula (I), salts or solvates thereof and pharmaceutical compositions containing same: wherein Z is N or CH or the Z(R1) part is replaced with a covalent bond, m and n is 0, 1, 2 or 3; HET is heteroaryl; X is CF3, halogen, CO-heterocyclyl, COOR3 or CONHR3; R1 is H, (CH2)o-aryl, (CH2)p-heteroaryl, (CH2)q-biphenyl; C(O)—R5; S(O)2—R6; R2 is H, aryl, heteroaryl, Y—(CH2)r-aryl, Y—(CH2)s-heteroaryl, where some of the above substituents may be substituted; Y is O or S; with the exclusion of the compound where HET is 1,3-thiazol, X is COOH, R1 is 4-fluorophenyl and R2 is benzyloxy. The invention also relates to the use of a compound of general formula (I), salts or solvates thereof for the use in the prevention or treatment of diseases where the activation of MMPs is involved in the pathomechanism. In this aspect the use of the above excluded compound is also inventive.
    Type: Application
    Filed: December 19, 2011
    Publication date: November 14, 2013
    Inventors: Péter Ferdinandy, Tamás Bálint Csont, Csaba Csonka, Krisztina Kedvesné Kupai, László Kovács, Attila Kis-Tamás, Ferenc Tamás Takács, Dénes Kónya, Gábor Medgyes, Sándor Cseh, István Hajdú, Zsolt Lõrincz, György Dormán, Anikó Görbe
  • Publication number: 20130280195
    Abstract: Compositions containing an effective dermatological disease-treating or dermatological condition-treating active agent and a pharmaceutically-acceptable carrier or vehicle are disclosed. Methods of using the compositions are also disclosed.
    Type: Application
    Filed: June 17, 2013
    Publication date: October 24, 2013
    Inventor: Bryan B. Fuller
  • Publication number: 20130281411
    Abstract: Compositions are disclosed that contain an effective inflammatory-dermatological disease-treating or condition-treating active agent and a pharmaceutically-acceptable carrier or vehicle. Methods of using the compositions to treat a subject's skin are also disclosed.
    Type: Application
    Filed: June 17, 2013
    Publication date: October 24, 2013
    Inventor: Bryan B. Fuller
  • Publication number: 20130274231
    Abstract: Compositions containing an effective dermatological disease-treating or dermatological condition-treating active agent and a pharmaceutically-acceptable carrier or vehicle are disclosed.
    Type: Application
    Filed: June 17, 2013
    Publication date: October 17, 2013
    Inventor: Bryan B. Fuller
  • Publication number: 20130210775
    Abstract: Provided is an agent for reducing odors of pyrazine derivatives based on an olfactory receptor antagonism. The agent for reducing odors of pyrazine derivatives includes at least one antagonist of olfactory receptor OR5K1 as an active ingredient.
    Type: Application
    Filed: December 4, 2012
    Publication date: August 15, 2013
    Applicant: Kao Corporation
    Inventor: Kao Corporation
  • Patent number: 8496951
    Abstract: Disclosed are pharmaceutical and cosmetic compositions containing aromatic aldehyde compounds. Some of the disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. Some of the compositions are useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: July 30, 2013
    Assignee: Allergan, Inc.
    Inventors: Charles R. Engles, Bryan Fuller, Brian Keith Pilcher
  • Publication number: 20130131121
    Abstract: A method of suppressing the proliferation of virus comprises administering an antiviral agent comprising as an effective component at least one member selected from the group consisting of 5,7,4?-trihydroxy-3?,5?-dimethoxyflavone, 3-hydroxypyridine, p-hydroxybenzaldehyde and vanillin to one in need of suppressing of viral proliferation.
    Type: Application
    Filed: January 18, 2013
    Publication date: May 23, 2013
    Inventor: Yuuzou TSUCHIDA
  • Patent number: 8398759
    Abstract: An ecologically compatible anti-microbial-adhesion agent is described, which is particularly suitable for use in anti-fouling paints, preferably for boats, characterized in that it comprises a compound selected from eugenol, vanillin, benzaldehyde substituted with one or two substituents selected from the groups —OH (hydroxy) and —OCH3 (methoxy), or any combination thereof. An anti-fouling paint is also described, particularly for boats, comprising the anti-microbial-adhesion agent mentioned above and other components selected from conventional biocides, solvents, resins, pigments, charges and fillings, and combinations thereof.
    Type: Grant
    Filed: May 12, 2009
    Date of Patent: March 19, 2013
    Assignee: Biopaint S.R.L.
    Inventors: Cecilia Calisti, Giulio Zanaroli, Fabio Fava, Alessandra Bontempi Di Roccaspada, Maurizio Ruzzi
  • Publication number: 20130053378
    Abstract: The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.
    Type: Application
    Filed: July 30, 2012
    Publication date: February 28, 2013
    Applicant: Erimos Pharmaceuticals LLC
    Inventors: Qingqi Chen, Jonathan Daniel Heller, Rocio Alejandra Lopez, Amanda Jean Morris
  • Publication number: 20130018107
    Abstract: The present invention relates to agricultural emulsion concentrates which form stable oil-in-water emulsions when diluted with water. More specifically, the invention relates to stable oil-in-water emulsions which include cinnamaldehyde and diallyl disulfide with a Calsogen® EH and Surfonic® CO 36 emulsion system. The increased stability of the emulsion allows for efficient mixing of the emulsion ingredients and effective storage and application of the cinnamaldehyde and diallyl disulfide to areas in need of nematode protection or treatment.
    Type: Application
    Filed: September 21, 2012
    Publication date: January 17, 2013
    Applicant: Valent BioSciences, Corporation
    Inventor: Valent BioSciences, Corporation
  • Publication number: 20130005810
    Abstract: The present invention relates to a method for controlling the growth of bacterial biomass in an aqueous system, including adding to the aqueous system or contacting the aqueous system, with an efficient amount of an uncoupling agent selected from vanillin, pentaerythritol and a betaine of general formula (1): (R)3N+?[CH2]n?CO2? wherein the R groups, are identical or different, and are selected from a linear or branched alkyl group having 1 to 8 carbon atoms, and n is a number between 1 and 5.
    Type: Application
    Filed: July 26, 2010
    Publication date: January 3, 2013
    Applicant: RHODIA OPERATIONS
    Inventors: Roland Jacquot, Luc Louvel, Philippe Marchal, Philippe Marion, Gilles Moreau, Agnes Pilas-Begue
  • Publication number: 20120295939
    Abstract: A method of suppressing the proliferation of virus comprises administering an antiviral agent comprising as an effective component at least one member selected from the group consisting of 5,7,4?-trihydroxy-3?,5?-dimethoxyflavone, 3-hydroxypyridine, p-hydroxybenzaldehyde and vanillin to one in need of suppressing of viral proliferation.
    Type: Application
    Filed: July 30, 2012
    Publication date: November 22, 2012
    Inventors: Yuuzou TSUCHIDA, Kunitomo WATANABE, Mamoru KOKETSU, Tsugiya MURAYAMA, Kotarou TSUCHIDA, Daisuke SAKURAI, Mitsuo KAWABE
  • Publication number: 20120294901
    Abstract: A process for producing a small-sized, lipid-based cochleates. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.
    Type: Application
    Filed: April 6, 2012
    Publication date: November 22, 2012
    Applicants: University of Medicine and Dentistry of New Jersey, BioDelivery Sciences International, Inc.
    Inventors: Leila Zarif, Tuo Jin, Ignacio Segarra, Raphael J. Mannino
  • Publication number: 20120277178
    Abstract: Compositions and methods of treatment or prophylaxis of fragile-X associated disorders are provided, as well as methods of screening compounds and kits to screen a library of compounds.
    Type: Application
    Filed: April 27, 2012
    Publication date: November 1, 2012
    Applicant: EMORY UNIVERSITY
    Inventors: Peng JIN, Abrar QURASHI
  • Patent number: 8268336
    Abstract: Disclosed are pharmaceutical and cosmetic compositions containing aromatic aldehyde compounds. Some of the disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. Some of the compositions are useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: September 18, 2012
    Assignee: Skinmedica, Inc.
    Inventors: Charles R. Engles, Bryan Fuller, Brian Keith Pilcher
  • Patent number: 8246971
    Abstract: Disclosed are pharmaceutical and cosmetic compositions containing aromatic aldehyde compounds. Some of the disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. Some of the compositions are useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.
    Type: Grant
    Filed: June 7, 2007
    Date of Patent: August 21, 2012
    Assignee: SkinMedica, Inc.
    Inventors: Charles R. Engles, Bryan Fuller, Brian Keith Pilcher
  • Patent number: 8246969
    Abstract: Disclosed are pharmaceutical and cosmetic compositions containing aromatic aldehyde compounds. Some of the disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. Some of the compositions are useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.
    Type: Grant
    Filed: August 15, 2002
    Date of Patent: August 21, 2012
    Assignee: Skinmedica, Inc.
    Inventors: Charles R. Engles, Bryan Fuller, Brian Keith Pilcher
  • Publication number: 20120190753
    Abstract: Disclosed are pharmaceutical and cosmetic compositions containing aromatic aldehyde compounds. Some of the disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. Some of the compositions are useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.
    Type: Application
    Filed: February 9, 2012
    Publication date: July 26, 2012
    Applicant: MERZ AESTHETICS, INC.
    Inventors: Charles R. Engles, Bryan Fuller, Brian Keith Pilcher
  • Publication number: 20120184513
    Abstract: The invention relates to organic compounds having the ability to reduce or suppress the onset of skin irritation induced by extraneous cause selected from the group of 2-heptylcyclopentanone, 2-ethoxynaphthalene; 2-methoxynaphthalene; 1-methoxy-4-(prop-1-enyl)benzene; 1-(cyclopropylmethyl)-4-methoxybenzene; wherein X, Y, and R1 to R11 have the same meaning as given in the description. Furthermore the invention refers to compositions for topical application to the skin comprising them. It further relates to a method of reducing or suppressing the formation of skin irritation.
    Type: Application
    Filed: January 14, 2011
    Publication date: July 19, 2012
    Applicant: Givaudan SA
    Inventors: Andreas NATSCH, Michael WASESCHA