Benzene Ring Containing Patents (Class 514/699)
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Patent number: 8246969Abstract: Disclosed are pharmaceutical and cosmetic compositions containing aromatic aldehyde compounds. Some of the disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. Some of the compositions are useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.Type: GrantFiled: August 15, 2002Date of Patent: August 21, 2012Assignee: Skinmedica, Inc.Inventors: Charles R. Engles, Bryan Fuller, Brian Keith Pilcher
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Patent number: 8246971Abstract: Disclosed are pharmaceutical and cosmetic compositions containing aromatic aldehyde compounds. Some of the disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. Some of the compositions are useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.Type: GrantFiled: June 7, 2007Date of Patent: August 21, 2012Assignee: SkinMedica, Inc.Inventors: Charles R. Engles, Bryan Fuller, Brian Keith Pilcher
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Publication number: 20120190753Abstract: Disclosed are pharmaceutical and cosmetic compositions containing aromatic aldehyde compounds. Some of the disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. Some of the compositions are useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.Type: ApplicationFiled: February 9, 2012Publication date: July 26, 2012Applicant: MERZ AESTHETICS, INC.Inventors: Charles R. Engles, Bryan Fuller, Brian Keith Pilcher
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Publication number: 20120184513Abstract: The invention relates to organic compounds having the ability to reduce or suppress the onset of skin irritation induced by extraneous cause selected from the group of 2-heptylcyclopentanone, 2-ethoxynaphthalene; 2-methoxynaphthalene; 1-methoxy-4-(prop-1-enyl)benzene; 1-(cyclopropylmethyl)-4-methoxybenzene; wherein X, Y, and R1 to R11 have the same meaning as given in the description. Furthermore the invention refers to compositions for topical application to the skin comprising them. It further relates to a method of reducing or suppressing the formation of skin irritation.Type: ApplicationFiled: January 14, 2011Publication date: July 19, 2012Applicant: Givaudan SAInventors: Andreas NATSCH, Michael WASESCHA
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Publication number: 20120157546Abstract: Disclosed are pharmaceutical and cosmetic compositions containing aromatic aldehyde compounds. Some of the disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. Some of the compositions are useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.Type: ApplicationFiled: February 28, 2012Publication date: June 21, 2012Applicant: Merz Aesthetics, Inc.Inventors: Charles R. Engles, Bryan Fuller, Brian Keith Pilcher
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Publication number: 20120093952Abstract: The present invention relates to the use of essential oil compounds as histomonastats. An example of a essential oil compound of the invention is cinnamaldehyde.Type: ApplicationFiled: November 20, 2008Publication date: April 19, 2012Inventors: Marco Frehner, Riccardo Losa, Didier Archain
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Patent number: 8088829Abstract: A novel combination of OPA, a surfactant, and alcohol. The surfactant is preferably a dual chain quaternary ammonium compound consisting of a mixture of alkyl dimethylbenzylammonium chlorides and alkyl dimethylethylbenzylammonium, that absorbs onto a surface and alters the free energy of that surface. The alcohol is preferably isopropyl alcohol. The OPA is the dialdehyde C6H4(CHO)2, which produces an inherent bacteriostatic effect and lowers surface tension and thus aids in the spread of the dual quat on the biofilm covered surface where it is readily absorbed by the negative surfaces of proteins and bacteria. It thus serves as a binding agent between the dual quat and the application surface. This multi purpose component helps create the unique aspect of the formulation.Type: GrantFiled: September 9, 2009Date of Patent: January 3, 2012Inventor: Howard Martin
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COMPOUNDS AND METHODS FOR REPELLING BLOOD-FEEDING ARTHROPODS AND DETERRING THEIR LANDING AND FEEDING
Publication number: 20110251270Abstract: This invention relates to a group of compounds for repelling blood-feeding ectoparasitic arthropods, and a method of deterring their landing and feeding on animals including humans, by applying in one or more formulations compounds that incorporate one or more sulfide and one or more hydroxyl groups to the skin, clothing or environment of animals, including humans. A method of repelling and deterring landing and feeding by blood-feeding arthropods on an animal by applying in effective amount one or more compounds that incorporate alkyl sulfide and alcohol moieties, or alkyl sulfide and amide moieties, or alkyl sulfide and amide moieties to the skin, clothing or environment of an animal.Type: ApplicationFiled: September 25, 2009Publication date: October 13, 2011Inventors: Regine M Gries, Grigori Khaskin, Gerhard G. Gries -
Publication number: 20110230565Abstract: A compound that includes vanillin and ethylvanillin, and a method for making same are described. The compound described can be obtained by the co-crystallisation of vanillin and ethylvanillin. Methods of using the compound in numerous applicable fields, particularly in human and animal food are also described.Type: ApplicationFiled: October 8, 2009Publication date: September 22, 2011Applicant: RHODIA OPERATIONSInventor: Jean-Claude Le-Thiesse
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Patent number: 8007771Abstract: The present invention relates to oral care compositions comprising stannous ions, a mint-type flavor oil, a protectant component that prevents generation of off odor and off taste in the composition, and orally acceptable carriers. The mint-type oils include peppermint, spearmint and corn mint. Suitable protectant components include copper salts and carbonyl compounds such as ascorbic acid; cis-jasmone; 2,5-dimethyl-4-hydroxy-3(2H)-furanone; 5-ethyl-3-hydroxy-4-methyl-2(5H)-furanone; vanillin; ethyl vanillin; anisaldehyde; 3,4-methylenedioxybenzaldehyde; 3,4-dimethoxybenzaldehyde; 4-hydroxybenzaldehyde; 2-methyoxybenzaldehyde; 4-methoxybenzaldehyde; benzaldehyde; cinnamaldehyde (3-phenyl-2-propenal); hexyl cinnamaldehyde; ?-methyl cinnamaldehyde; ortho-methoxy cinnamaldehyde; ?-amyl cinnamaldehyde; and combinations thereof. The oral care composition may be a dentifrice.Type: GrantFiled: July 5, 2007Date of Patent: August 30, 2011Assignee: The Procter & Gamble CompanyInventors: Niranjan Ramji, Marc Hester, Steve Hoke, Robert Leslie Swaine, Jr., Gerhard Norbert Zehentbauer
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Patent number: 7981939Abstract: Use of 2-bromo-isovanillin in the preparation of an anticancer medicament and/or radio- and chemotherapy sensitizing medicament is disclosed. The medicament for the treatment of cancers and/or for radio- and chemotherapy sensitization comprising 2-bromo-isovanillin as active ingredient provided herein has the following features: (1) low toxicity, without evident adverse effects; (2) significant therapeutic effect, with remarkable proliferation inhibiting and pro-apoptotic effects in tumor cells; (3) a broad-spectrum anticancer activity; (4) suitable to be used in combination with antimetabolites, to enhance the effects and meanwhile lower the toxicity, and also to reduce multi-drug resistance; (5) convenient and safe administration, the main route being oral.Type: GrantFiled: February 25, 2008Date of Patent: July 19, 2011Assignee: Institute of Radiation Medicine, Academy of Military Medical Sciences, PLAInventors: Pingkun Zhou, Yuqian Yan, Lin Wang, Jianli Sui
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Publication number: 20110171195Abstract: Methods and compositions are provided for treating a urinary tract infection (UTI). The methods involve administering to a subject in need thereof a cAMP elevator or agent that mimics cAMP, particularly a labdane diterpene such as forskolin or a derivative or analog thereof in a therapeutically effective amount to treat a UTI. The methods may further include administration of at least one cAMP elevator in combination with one or more additional active compounds from other classes of therapeutic agents, such as antimicrobial agents or cholesterol lowering drugs. Compositions of the invention include pharmaceutical compositions and kits for treating a UTI in a subject in need thereof that include therapeutically effective amounts of at least two cAMP elevators, particularly where one of the cAMP elevators is a labdane diterpene such as forskolin or a derivative or analog thereof.Type: ApplicationFiled: June 12, 2008Publication date: July 14, 2011Applicant: Duke UniversityInventors: Soman N. Abraham, Brian L. Bishop, Matthew J. Duncan, K. Ranga Rama Krishnan, Jeongmin Song, Guojie Li, David A. Zaas
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Patent number: 7968605Abstract: A method is disclosed for treating inflammatory disease in an animal in need thereof by administering to the animal a pharmaceutical composition containing an anti-inflammatory effective amount of an organic aldehyde compound or a derivative thereof in a pharmaceutically acceptable vehicle.Type: GrantFiled: February 6, 2007Date of Patent: June 28, 2011Assignee: ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda.Inventors: Marta Norton De Matos, Carlos C. Romao
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Publication number: 20110104223Abstract: A sporicidal composition comprising an aromatic dialdehyde; a medium chain linear alcohol; a surfactant; greater than 0.2% by weight based on the total weight of the composition of a base; and water, wherein the sporicidal composition is a microemulsion having a pH ranging from about 11 to about 13.Type: ApplicationFiled: October 30, 2009Publication date: May 5, 2011Inventor: Qiang Li
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Publication number: 20110098362Abstract: Use of 2-bromo-isovanillin in the preparation of an anticancer medicament and/or radio- and chemotherapy sensitizing medicament is disclosed. The medicament for the treatment of cancers and/or for radio- and chemotherapy sensitization comprising 2-bromo-isovanillin as active ingredient provided herein has the following features: (1) low toxicity, without evident adverse effects; (2) significant therapeutic effect, with remarkable proliferation inhibiting and pro-apoptotic effects in tumor cells; (3) a broad-spectrum anticancer activity; (4) suitable to be used in combination with antimetabolites, to enhance the effects and meanwhile lower the toxicity, and also to reduce multi-drug resistance; (5) convenient and safe administration, the main route being oral.Type: ApplicationFiled: February 25, 2008Publication date: April 28, 2011Inventors: Pingkun Zhou, Yuqian Yan, Lin Wang, Jianli Sui
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Publication number: 20110044969Abstract: The invention provides an antimicrobial agent for use in the treatment of a Campylobacter species which has colonised the crop of a bird, wherein the bird is exposed to said antimicrobial agent one or more times and products for carrying out the same.Type: ApplicationFiled: February 9, 2009Publication date: February 24, 2011Applicant: NOFIMA MAT ASInventors: Knut Rudi, Magne Kaldhusdal, John Nordal
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Publication number: 20110015227Abstract: The invention relates to a warming sensate composition of (i) a hot component, (ii) a cooling component, and (iii) optionally a bitter component. The weight ratio of (i):(ii) is from 1:3 to 1:100. If a solvent is provided in the composition, the solvent is present in an amount of less than 10 wt % ethanol, based on the total weight of the composition. Also, the bitter component, when used, is present in an amount of less than 0.15% by weight based on the total weight of the composition.Type: ApplicationFiled: April 6, 2009Publication date: January 20, 2011Applicant: FIRMENICH SAInventors: Bernadita Desierto, Anh Le, Nicole Staniec, John Zanone
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Publication number: 20100284942Abstract: There are provided personal care products and compositions that comprise at least one diol compound selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 2-methyl-1,3-propandiol, and 3-(2-ethyl-hexyloxy)-1,2-propandiol in a total concentration of 0.1% to 0.5% (w/w); and at least one preservative enhancer compound selected from the group consisting of benzaldehyde, 4-methylbenzaldehyde, heliotropine, vanilline, 4-hydroxybenzaldehyde, 3-hydroxybenzaldehyde, 4-methoxybenzaldehyde and 3-methoxybenzaldehyde, 2,4-dihydroxybenzaldehyde, 3-hydroxy-4-methoxybenzaldehyde, 3,5-dihydroxybenzaldehyde, and 4-hydroxy-2-methoxybenzaldehyde, in a total concentration of 0.05 to 0.5% (w/w), in a cosmetically acceptable base. The composition optionally contains at least one compound selected from the group consisting of phenoxyethanol, 2-phenylethanol, and benzylalcohol, in a total concentration of 0.05 to 0.Type: ApplicationFiled: December 11, 2007Publication date: November 11, 2010Applicant: Givaudan SAInventor: Andreas Natsch
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Patent number: 7825104Abstract: Phenylboronic acid and water soluble derivatives thereof and related boronic acid compounds are used for treating fungal and bacterial infections.Type: GrantFiled: July 23, 2002Date of Patent: November 2, 2010Assignee: Ramot at Tel Aviv University Ltd.Inventors: Amihay Freeman, Rina Segal, Yael Dror
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Publication number: 20100249165Abstract: This invention relates to compounds useful as PDZ domain modulators, in particular the PDZ domain of PICK1. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions.Type: ApplicationFiled: June 3, 2008Publication date: September 30, 2010Applicants: University of Copenhagen, NeuroSearch A/SInventors: Ulrik Gether, Kenneth Madsen, Thor Seneca Thorsen, Dan Peters, Tino Dyhring, Lars Christian Rønn
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Publication number: 20100249244Abstract: The presently claimed and disclosed inventive concept(s) contemplates compositions comprising compounds, in particular dihydroeugenol (DHE) and/or isoeugenol (IE) and/or ethyl vanillin (EV) or salts, esters, ethers, or derivatives thereof, and methods for topically or systemically delivering them for treatment against inflammation-related and other dermatological conditions such as described herein. These DHE and/or IE and/or EV or salts, esters, ethers or derivatives thereof also are delivered to a measurable extent transepidermally or transdermally.Type: ApplicationFiled: March 31, 2010Publication date: September 30, 2010Inventor: Bryan B. Fuller
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Publication number: 20100234456Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.Type: ApplicationFiled: May 25, 2010Publication date: September 16, 2010Applicant: ABBOTT LABORATORIESInventors: Michael D. Wendt, Hong Ding, Sheela A. Thomas, Steven W. Elmore, Wang Shen, Daniel A. Dickman, David Augeri
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Publication number: 20100190832Abstract: Transthyretin (TTR), a tetrameric thyroxine (T4) carrier protein, is associated with a variety of amyloid diseases. Derivative of biphenyl ethers (BPE), which are shown to interact with a high affinity to its T4 binding site thereby preventing its aggregation and fibrillogenesis. They prevent fibrillogenesis by stabilizing the tetrameric ground state of transthyretin. Two compounds (2-(5-mercapto-[1,3,4]oxadiazol-2-yl)-phenol and 2,3,6-trichloro-N-(4H-[1,2,4]triazol-3-yl) exhibit the ability to arrest TTR amyloidosis. The dissociation constants for the binding of BPEs and compound 11 and 12 to TTR correlate with their efficacies of inhibiting amyloidosis. They also have the ability to inhibit the elongation of intermediate fibrils as well as show nearly complete (>90%) disruption of the preformed fibrils. Biphenyl ethers and compounds 11 and 12 as very potent inhibitors of TTR fibrillization and inducible cytotoxicity.Type: ApplicationFiled: October 15, 2009Publication date: July 29, 2010Inventor: Avadhesha Surolia
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Publication number: 20100183753Abstract: A composition for the control of nematodes consisting of salicylaldehyde and a surfactant. Garlic extract added to the salicylaldehyde provides a composition that demonstrates a more potent control action against potato cyst nematodes.Type: ApplicationFiled: June 11, 2008Publication date: July 22, 2010Inventors: Gidon BAHIRI, Lan ELLIOTT
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Publication number: 20100137379Abstract: Antimicrobial lubricant compositions are disclosed. The antimicrobial lubricant compositions are particularly useful in providing antimicrobial capability to a wide-range of medical devices. The compositions include an oil lubricant. Representative lubricants may include polydimethyl siloxane, trifluoropropyl copolymer polysiloxane, and a copolymer of dimethylsiloxane and trifluoropropylmethylsiloxane. The compositions include rheology modifiers as necessary. The compositions also include antimicrobial agents, which may be selected from a wide array of agents. Representative antimicrobial agents include of aldehydes, anilides, biguanides, bis-phenols, quaternary ammonium compounds, cetyl pyridium chloride, cetrimide, alexidine, chlorhexidine diacetate, benzalkonium chloride, and o-phthalaldehyde.Type: ApplicationFiled: May 6, 2009Publication date: June 3, 2010Applicant: BECTON, DICKINSON AND COMPANYInventor: David Tien-Tung Ou-Yang
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Publication number: 20100068237Abstract: A germicidal composition comprising an aromatic dialdehyde; a medium chain linear alcohol; a surfactant; at least one enhancer selected from the group consisting of a halide salt, a carbonate and a carboxylate salt; and water, wherein the germicidal composition is a microemulsion.Type: ApplicationFiled: October 30, 2009Publication date: March 18, 2010Inventors: Qiang Li, Chris French, Charles Roberts
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METHOD FOR PREPARING PARTICLES COMPRISING METAL OXIDE COATING AND PARTICLES WITH METAL OXIDE COATING
Publication number: 20100016443Abstract: The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer. The invention further relates to particles comprising a particulate matter coated by a metal oxide layer, to a use of the particles for topical administration, and to a method for preventing, reducing, or eliminating pests at a locus, using the particles.Type: ApplicationFiled: February 3, 2008Publication date: January 21, 2010Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Ofer Toledano, Haim Bar-Simantov, Nissim Bilman, Leora Shapiro, Raed Abu-Reziq, Srikanth Sriadibhatla, William T. Sommer -
Publication number: 20090258889Abstract: The present disclosure relates to pesticidal compositions and to methods for controlling pests such as insects and other arthropods. More particularly, the disclosure relates to a pesticidal compositions containing mineral oil and one or more additional components which, when used in combination, act synergistically to control insect and pest populations.Type: ApplicationFiled: April 3, 2009Publication date: October 15, 2009Applicant: Whitmire Micro-Gen Research Laboratories, Inc.Inventor: Steven R. Sims
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Publication number: 20090238785Abstract: A compound comprising a Schiffs base of an aldehydic musk aromachemical with a substantially nonvolatile, odorless amine, wherein the imine moiety of said Schiffs base compound is stable against oxidation to a carboxyl group or a mixture of said compounds; said Schiffs base compound being biodegradable over time to said aldehydic musk and said nonvolatile, odorless amine; as well as compositions, products, preparations or articles having improved aroma, fragrance or odor characteristics containing as active ingredient such compound or mixture of compounds; the aldehydic musks themselves, and methods for the preparation of the Schiff bases and methods of imparting fragrance characteristics to substrates.Type: ApplicationFiled: June 24, 2005Publication date: September 24, 2009Applicant: Flexitral, Inc.Inventor: Luca Turin
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Publication number: 20090111895Abstract: High-level disinfectant formulations and sporicidal formulations suitable for use as chemical disinfection and sterilization mediums comprising a dialdehyde, a carboxylate salt in amount of from about 3 weight percent to about 20 weight percent, and the balance water. The formulations are useful for disinfecting and sterilizing medical instruments and medical equipment.Type: ApplicationFiled: July 28, 2008Publication date: April 30, 2009Applicant: Ethicon, Inc.Inventors: Peter C. Zhu, Yvonne Tran, Kaitao Lu, Xiaolan Chen, Harriet Chan-Myers
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Publication number: 20090076136Abstract: The present invention relates to a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an insulin-mimetic action agent, a food, beverage, or feed, an agent for enhancement of glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, each comprising as an effective ingredient at least one compound selected from the group consisting of specified compounds having an insulin-mimetic action, derivatives thereof, and pharmacologically acceptable salts thereof.Type: ApplicationFiled: November 3, 2008Publication date: March 19, 2009Inventors: Tatsuji ENOKI, Eiji Kobayashi, Kinuko Ogawa, Yoko Kudo, Masashige Tanabe, Hiromu Ohnogi, Hiroaki Sagawa, Ikunoshin Kato
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Publication number: 20090018211Abstract: A method for inhibiting of COX2 and inflammation by administering a hydroxybenzaldehyde.Type: ApplicationFiled: July 9, 2007Publication date: January 15, 2009Applicant: Board of Trustees of Michigan State UniversityInventors: Muraleedharan G. Nair, Mulabagal Vanisree, Ruby L. Alexander-Lindo, David L. DeWitt
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Publication number: 20090012128Abstract: A microbicidal agent comprising as an effective ingredient at least one selected from the group consisting of p-hydroxybenzaldehyde, 5,7,4?-trihydroxy-3?,5?-dimethoxyflavone, 3-hydroxypyridine and vanillin, and a microbicidal composition comprising the microbicidal agent.Type: ApplicationFiled: September 10, 2008Publication date: January 8, 2009Inventors: Yuuzou TSUCHIDA, Kotarou Tsuchida, Kunitomo Watanabe, Daisuke Sakurai, Mamoru Koketsu, Mitsuo Kawabe, Teruo Utsumi
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Publication number: 20090004120Abstract: Provided are personal care products and compositions that comprise at least one preservative compound selected from the group consisting of phenoxyethanol, 2-phenyl ethanol, phenoxypropanol, 3-phenylpropanol and benzylalcohol, in a total concentration of 0.1 to 1% (w/w); and at least one preservative enhancer compound selected from the group consisting of 4-methylbenzaldehyde, heliotropine, vanilline, 4-hydroxybenzaldehye, 3-hydroxybenzaldehyde, 4-methoxybenzaldehyde, 3-methoxybenzaldehyde, 2,4-dihydroxybenzaldehyde, 3-hydroxy-4-methoxybenzaldehyde, 3,5-dihydroxybenzaldehyde, and 4-hydroxy-2-methoxybenzaldehyde, in a total concentration of 0.05 to 0.5% (w/w), in a cosmetically acceptable base. The composition does not contain certain classic bactericidal, fungicidal, sporicidal or preservative compounds. Further provided are methods of forming such compositions and products and the use of preservatives and preservative enhancers in such compositions and products.Type: ApplicationFiled: December 18, 2006Publication date: January 1, 2009Applicant: GIVAUDAN SAInventor: Andreas Natsch
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Publication number: 20080317835Abstract: Assays are preformed to determine nutrient deficiency levels in an individual to address the deficiencies and improve health and longevity. Nutraceutical and cosmeceutical products containing nanoencapsulated active ingredients are provided, in addition to dietary, exercise, sleep, and other lifestyle recommendations.Type: ApplicationFiled: June 20, 2007Publication date: December 25, 2008Inventors: Nazli Azimi, Mohammad Saeed Kharazmi
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Publication number: 20080311233Abstract: Two phenolic compounds occurring in nature were useful in the control of some pests. Salicylaldehyde is a substance produced by some plants and some animals. A novel pest control agent is based on salicylaldehyde. It is active against caterpillars (larvae of butterflies and moths) as well as earthworms and molluscs. In combination with garlic extract it enhances the activity of such extract. An agent for the control of insects in agriculture comprises vanillin. The vanillin powder is solubilised in water for spraying onto insects infesting crops.Type: ApplicationFiled: April 20, 2005Publication date: December 18, 2008Inventor: Yoram Tsivion
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Publication number: 20080287441Abstract: Compounds having a formula: or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.Type: ApplicationFiled: April 22, 2008Publication date: November 20, 2008Applicant: Metabolex, Inc.Inventors: Zuchun Zhao, Xin Chen, Jianchao Wang, Hongbin Sun, Jack Shih-Chieh Liang
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Patent number: 7432307Abstract: Described herein are methods and compositions for the detection of transthyretin (TTR), retinol binding protein (RBP) and retinol complex formation. The methods and compositions described herein also provide for the screening of modulators of retinol-RBP-TTR complex formation. Furthermore, the methods and compositions provide for therapeutic agents for the treatment and/or prevention of age-related macular degeneration and/or dystrophies.Type: GrantFiled: November 4, 2005Date of Patent: October 7, 2008Assignee: Sirion Therapeutics, Inc.Inventors: Nathan L. Mata, Kenneth Widder, Jay Lichter
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Publication number: 20080221221Abstract: Use of 2-bromo-isovanillin in the preparation of an anticancer medicament and/or radio- and chemotherapy sensitizing medicament is disclosed. The medicament for the treatment of cancers and/or for radio- and chemotherapy sensitization comprising 2-bromo-isovanillin as active ingredient provided herein has the following features: (1) low toxicity, without evident adverse effects; (2) significant therapeutic effect, with remarkable proliferation inhibiting and pro-apoptotic effects in tumor cells; (3) a broad-spectrum anticancer activity; (4) suitable to be used in combination with antimetabolites, to enhance the effects and meanwhile lower the toxicity, and also to reduce multi-drug resistance; (5) convenient and safe administration, the main route being oral.Type: ApplicationFiled: February 25, 2008Publication date: September 11, 2008Inventors: Pingkun Zhou, Yuqian Yan, Lin Wang, Jianli Sui
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Publication number: 20080220103Abstract: Provided is a method of treating a fungal infection on an animal epidermis, nail or hair, or in an orifice of an animal. The method comprises contacting the fungus infection with a composition comprising an antifungal botanical.Type: ApplicationFiled: March 13, 2008Publication date: September 11, 2008Inventors: Jay Birnbaum, Thomas Blake, Mahmoud Ghannoum, Steven Vallespir
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Patent number: 7390837Abstract: Germicidal compositions containing phenylmalonaldehyde-type compounds, or mixtures of phenylmalonaldehyde-type compounds and phthalaldehydes, and methods of using such compositions for killing bacteria, disinfection, or sterilization, are disclosed. In one aspect, a germicidal composition may include a diluent, and a germicidal compound having the formula: wherein Ar is an aryl group that is selected from the group consisting of phenyl, 4-pyrimidinyl, and 2-(2-nitro-3-formyl-phenyl). In a further aspect, the composition may also include a germicidal efficacy enhancer such as isophthalaldehyde or a combination of isophthalaldehyde and terephthalaldehyde.Type: GrantFiled: January 30, 2004Date of Patent: June 24, 2008Assignee: Ethicon, Inc.Inventors: Peter C. Zhu, Charles G. Roberts
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Patent number: 7384646Abstract: The purpose of the present invention is to provide antiseptic disinfectant, and cosmetics and toiletries, medicine or food containing the same, which enhance the antibacterial activity that 1,2-alkanediol originally have against a broad range of strains by compounding 1,2-alkanediol with 5-10 carbons and a certain fragrance component. The present invention relates to an antiseptic disinfectant, and cosmetics and toiletries, medicine or food containing the same, which include 1,2-alkanediol with 5-10 carbons, and one or more materials selected from a group of citral, geraniol, nerol, perillaldehyde, ?-terpineol, dodecanol and L-carvone.Type: GrantFiled: September 25, 2003Date of Patent: June 10, 2008Assignee: Mandom CorporationInventors: Aki Kobayashi, Hiroya Okamoto, Fumihiro Okada
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Publication number: 20080118591Abstract: The invention relates to bactericidal formulations that come into contact with human body, particularly wash formulations including liquid soaps, comprising perfume ingredients active against gram-negative bacteria. Such compositions contact the target site, for example the skin surface, only for a short time, usually not longer than 30 seconds. Therefore the antibacterial action has to be of the bactericidal type and rapid. Furthermore, the bactericidal activity has to be sufficiently high to ensure an effect even when applied to wet substrates that will dilute the bactericidal formulation.Type: ApplicationFiled: November 15, 2005Publication date: May 22, 2008Inventor: Andreas Natsch
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Patent number: 7176243Abstract: This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of CaR receptor expressing cells of hematopoietic, neural, epithelial, endothelial, or mesenchymal origin, in a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to modulate migratory-cell movement associated with specific sites in a subject. Specific sites include sites of inflammation and modulation of migratory-cell movement is movement away from an agent source, or repulsion. The invention also relates to methods for manipulating hematopoeitic progenitor cells and related products.Type: GrantFiled: November 1, 2001Date of Patent: February 13, 2007Assignees: The General Hospital Corporation, The Brigham and Women's Hospital, Inc.Inventors: Mark C. Poznansky, David T. Scadden, Ivona T. Olszak, Edward M. Brown
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Patent number: 7056537Abstract: The present invention relates to a method of abating hydrogen sulfide gas emitted by or generated in landfills. Certain embodiments of the present invention relate to contacting hydrogen sulfide gas with Fuller's earth or other carrier materials and metals such as silver, copper, iron, zinc or mixtures thereof, and other components.Type: GrantFiled: March 11, 2004Date of Patent: June 6, 2006Assignee: Aceto CorporationInventor: Richard Weschler
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Patent number: 6984389Abstract: The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an ?-2-macroglobulin (?2M) preparation with a non-vaccine treatment modality. In particular, an HSP preparation or an ?2M preparation is administered in conjunction with a non-vaccine treatment modality for the treatment of cancer or infectious diseases. In the practice of the invention, a preparation comprising HSPs such as but not limited to, hsp70, hsp90 and gp96 alone or in combination with each other, noncovalently or covalently bound to antigenic molecules or ?2M, noncovalently or covalently bound to antigenic molecules is administered in conjunction with a non-vaccine treatment modality.Type: GrantFiled: December 16, 2002Date of Patent: January 10, 2006Assignee: University of Connecticut Health CenterInventor: Zihai Li
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Patent number: 6949682Abstract: The present invention relates to cinnamaldehyde derivatives inhibiting growth of tumor cell and regulating cell cycle, the method for preparation and the pharmaceutical composition thereof. The cinnamaldehyde derivatives of the present invention can be effectively used as a cell cycle regulator or a cancer cell growth inhibitor, since it has an ability to regulate cell cycle by holding the cells in G2/M stage of the cell division and has activity to inhibit cancer cell growth.Type: GrantFiled: May 28, 2004Date of Patent: September 27, 2005Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Byoung-Mog Kwon, Kwang-Hee Son, Dong Cho Han, Sangku Lee, Jong Han Kim, Sung-Gyu Choi, Mi-Young Lee, Sun Bok Jeon
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Patent number: 6949586Abstract: The present invention relates to a synergistic hepatoprotective pharmaceutical composition comprising an effective amount of trans-tetracos-15-enoic acid (TCA) and Apocynin (APO), the present invention also relates to a method of treatment for hepatotoxicity in mammals and humans.Type: GrantFiled: March 20, 2002Date of Patent: September 27, 2005Assignee: Council of Scientific ResearchInventors: Sukhdev Swami Handa, Om Parkash Suri, Vishwa Nath Gupta, Krishan Avtar Suri, Naresh Kumar Satti, Vikram Bhardwaj, Bupinder Singh, Bal Krishan Chandan
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Patent number: 6903239Abstract: The present invention relates to fluorinated benzaldehydes, to a process for preparing them and also to the use of the fluorinated benzaldehydes for preparing active ingredients, especially in medicaments and agrochemicals.Type: GrantFiled: November 21, 2003Date of Patent: June 7, 2005Assignee: Bayer Chemical AktiengesellschaftInventors: Karen Peilstöcker, Albrecht Marhold
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Patent number: 6838106Abstract: This invention relates to a warming composition for food and drink or for oral care preparations which produces an excellent and long-lasting warming effect and causes no or little irritation to mucous membranes, a flavor composition for food and drink or for oral care preparations which comprises the warming composition, and beverages or oral care preparations which contain the warming composition or the flavor composition.Type: GrantFiled: December 10, 2001Date of Patent: January 4, 2005Assignee: Takasago International CorporationInventors: Hiroyasu Kumamoto, Tatsuo Kitamura