Benzene Ring Containing Patents (Class 514/699)
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Patent number: 5906992Abstract: The present invention relates to a foam composition for killing dust mites comprising an acaricidal agent, polymer, ether solvent, perfume, surfactant and water.Type: GrantFiled: November 21, 1996Date of Patent: May 25, 1999Assignee: Colgate Palmolive CompanyInventors: Pierre Fonsny, Germaine Zocchi
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Patent number: 5902831Abstract: A method for the prevention and treatment of atherosclerosis and its related diseases in mammals, in which an NADPH oxidase inhibitor is administered, is provided. The NADPH oxidase inhibitor prevents the production of reactive oxygen species upon exposure of endothelial cells to atherogenic LDL levels, thus resulting in decreased endocytosis and vascular hyperpermeability. Preferred NADPH oxidase inhibitors are of the formula: ##STR1## Additionally, there is provided a diagnostic method for predicting risk of a human patient to atherosclerotic-related diseases.Type: GrantFiled: May 23, 1997Date of Patent: May 11, 1999Assignee: The Research Foundation of State University of New YorkInventors: James Arthur Holland, David K. Johnson
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Patent number: 5900244Abstract: A method of attracting insects selected from the group consisting of houseflies, mosquitoes and wasps to a particular location, which method comprises placing at the said location a lure containing an effective attractant composition which comprises at least one compound which is a substituted benzenederivative having one or more short side chains, the said compound being volatile at room temperature and having a molecular weight in the range of from 115 to 155.Type: GrantFiled: July 10, 1996Date of Patent: May 4, 1999Assignee: University of SouthamptonInventor: Philip Edwin Howse
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Patent number: 5895657Abstract: Liquid vanillin compositions, well suited as flavoring/perfuming agents for a wide variety of applications, for example in human and animal foodstuffs, cosmetics and perfumes, comprise (a) vanillin, (b) ethylvanillin and (c) an aqueous and/or organic solvent therefor.Type: GrantFiled: June 29, 1995Date of Patent: April 20, 1999Assignee: Rhone-Poulenc ChimieInventors: Frederic Fournet, Fran.cedilla.oise Truchet
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Patent number: 5872153Abstract: A process for preparing an aqueous o-phthalaldehyde-glutaraldehyde solution which comprises converting an acetal of the o-phthalaldehyde in a 10 to 60% strength aqueous glutaraldehyde solution into o-phthalaldehyde at room temperature up to 100.degree. C. by eliminating the corresponding alcohol, and removing the eliminated alcohol to give the aqueous o-phthalaldehyde-glutaraldehyde solution.Type: GrantFiled: November 26, 1997Date of Patent: February 16, 1999Assignee: DSM Chemie Linz GmbHInventors: Karl Heinz Giselbrecht, Eduard Perndorfer
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Patent number: 5861385Abstract: Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments.Type: GrantFiled: August 8, 1995Date of Patent: January 19, 1999Assignee: Bayer AktiengesellschaftInventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, deceased, Hilmar Bischoff, Hans-Peter Krause, Jorg Petersen von Gehr, Delf Schmidt
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Patent number: 5843215Abstract: Coatings which comprise a water-based or water soluble resin and plant secondary compounds are described. The plant secondary compounds useful in the present invention consist of those compounds which have insecticidal characteristics. The coatings of the present invention have characteristics of insect repellence, antifeedance and oviposition deterrence.Type: GrantFiled: April 7, 1997Date of Patent: December 1, 1998Assignee: WARMM Sciences, LLCInventors: Mark E. Whalon, Gene E. Malloy
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Patent number: 5807587Abstract: A composition and method for preventing and/or reducing stench and septicity from animal waste comprising a sulfur and oxygen-bearing component and one or more aldehydes and/or one or more ketones. The sulfur and oxygen-bearing component is selected from the group consisting of sodium bisulfite, potassium bisulfite, lithium bisulfite, sodium metabisulfite, potassium metabisulfite, lithium metabisulfite, sodium hydrosulfite, potassium hydrosulfite, lithium hydrosulfite and hydrogen sulfite. The aldehyde is selected from the group consisting of formaldehyde, glyoxal, glutaraldehyde, benzaldehyde, acetaldehyde, butryaldehyde, cinnamaldehyde, anisaldehyde, salicylaldehyde, citral, glycolic aldehyde, paraldehyde, metaldehyde, heptylaldehyde, octylaldehyde and decylaldehyde. The ketone is selected from the group consisting of diacetyl, ionone, pseudo-ionone, acetylacetone, 3-buten-2-one, mesityl oxide, acetone, methyl ethyl ketone, diethyl ketone and dipropyl ketone.Type: GrantFiled: February 11, 1997Date of Patent: September 15, 1998Inventors: James P. Cox, Robert W. Duffy Cox
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Patent number: 5783600Abstract: Dialkyl ethers lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.Type: GrantFiled: February 25, 1997Date of Patent: July 21, 1998Assignee: Warner-Lambert CompanyInventors: Charles Larry Bisgaier, Paul Leroy Creger, Alan Robert Saltiel, Sherrie Rae Tafuri
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Patent number: 5763496Abstract: A method for the prevention and treatment of atherosclerosis and its related diseases in mammals is provided, in which an NADPH oxidase inhibitor is administered to mammals. The NADPH oxidase inhibitor prevents the production of reactive oxygen species upon exposure of endothelial cells to atherogenic LDL levels, resulting in decreased endocytosis and vascular hyperpermeability. Apocynin is a preferred NADPH oxidase inhibitor. Additionally, there is provided a diagnostic method for predicting the risk to an individual of atherosclerotic-related diseases.Type: GrantFiled: November 27, 1995Date of Patent: June 9, 1998Assignee: The Research Foundation of State University of New YorkInventor: James Arthur Holland
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Patent number: 5756544Abstract: Dialkyl ethers lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.Type: GrantFiled: February 25, 1997Date of Patent: May 26, 1998Assignee: Warner-Lambert CompanyInventors: Charles Larry Bisgaier, Paul Leroy Creger, Alan Robert Saltiel, Sherrie Rae Tafuri
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Patent number: 5750569Abstract: Dialkyl ethers lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.Type: GrantFiled: February 25, 1997Date of Patent: May 12, 1998Assignee: Warner-Lambert CompanyInventors: Charles Larry Bisgaier, Paul Leroy Creger, Alan Robert Saltiel, Sherrie Rae Tafuri
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Patent number: 5736032Abstract: Biowaste treatment agents for treating biowastes in a manner which: (a) keeps noxious and toxic substances from being released from the biowaste, and (b) neutralizes such substances released during the course of stabilizing the biowaste. The treatment agents include a surfactant in an amount of from 1.0 to 99 percent of the treatment agent, a metal component in an amount from 0.5 to 85 percent of the treatment agent, the metal component including a source of zinc, or copper, or a combination of copper with aluminum or iron, and an aldehyde in an amount from 0.1 to 80 percent of the treatment agent.Type: GrantFiled: October 11, 1996Date of Patent: April 7, 1998Inventors: James P. Cox, Robert W. Duffy Cox
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Patent number: 5733909Abstract: The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.Type: GrantFiled: January 21, 1997Date of Patent: March 31, 1998Assignee: Merck Frosst Canada, Inc.Inventors: Cameron Black, Mario Girard, Daniel Guay, Zhaoyin Wang
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Patent number: 5693344Abstract: A hazard-free method for controlling insects using a non-toxic composition. The invention includes a process for making the composition in the form of a fragrance and crystalline particles which puncture directly through the exoskeleton of an insect. In operation, the particles work themselves between the insect's protective body plates and then puncture the exoskeleton permitting entry of the fragrance into the body of the insect. Once inside, the particles absorb up to four times their weight of the vital body fluids of the insect and the fragrance has a neural effect on the insect.Type: GrantFiled: November 9, 1995Date of Patent: December 2, 1997Assignee: Ecosmart, Inc.Inventors: Arthur Michael Knight, Steven M. Bessette
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Patent number: 5668182Abstract: Various hydroxy benzaldehyde derivatives including Vanillin, a natural product derived from the vanilla bean that is commonly used as a flavoring agent, is administered by injection (i.v., i.m., s.c., and the like) or intravenous infusion in an effective dose amount to a patient in need of calming or sedation.Type: GrantFiled: August 19, 1996Date of Patent: September 16, 1997Assignee: Virginia Commonwealth UniversityInventors: Donald J. Abraham, Louis S. Harris, B. J. Meade, Albert E. Munson, Paul S. Swerdlow, Graham A. Patrick
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Patent number: 5665344Abstract: Compositions of cis-jasmone were found to effectively attract adult Lepidoptera. The cis-jasmone may be used alone or in combination with one or more other volatiles of the Japanese honeysuckle flower, particularly linalool and/or phenylacetaldehyde. By attracting the adult Lepidoptera to attracticidal baits and/or field traps, the attractants are useful for the control and monitoring of these agricultural pests.Type: GrantFiled: November 9, 1995Date of Patent: September 9, 1997Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Sammy D. Pair, Robert J. Horvat
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Patent number: 5654329Abstract: Compounds of the formula ##STR1## where W is (CH.sub.2).sub.n where n is 1 or 2, or n is 0 and W represents lower alkyl groups attached to each oxygen;m is an integer between 1 and 8;R.sub.1 is COOH or a pharmaceutically acceptable salt thereof, COOR.sub.4, CONR.sub.5 R.sub.6, CONR.sub.5 SO.sub.2 R.sub.7, CH.sub.2 OH, CH.sub.2 OR.sub.7, CH.sub.2 O--COR.sub.7, CH.sub.2 O--CONR.sub.5 R.sub.7, CH.sub.2 OCOOR.sub.7, CH.sub.2 NH.sub.2, CH.sub.2 NR.sub.5 R.sub.6, CH.sub.2 NR.sub.5 COR.sub.7, CHO, CH(OR.sub.8).sub.2, CH(OR.sub.9 O), --COR.sub.10, CR.sub.10 (OR.sub.8).sub.2, or CR.sub.10 OR.sub.9 O, where R.sub.4 is an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R.sub.4 is phenyl or lower alkylphenyl, R.sub.5 and R.sub.6 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or phenyl or lower alkylphenyl, R.sub.7 is alkyl of 1 to 10 carbons, phenyl or lower alkylphenyl, R.sub.8 is lower alkyl, and R.sub.Type: GrantFiled: June 7, 1995Date of Patent: August 5, 1997Assignee: AllerganInventors: Robert M. Burk, David F. Woodward
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Patent number: 5654331Abstract: Diaromatic compounds, characterised in that they correspond to the following general formula: ##STR1## in which: R.sub.1 is --CH.sub.3, --CH.sub.2 OH, --COR.sub.8 or --CH.sub.2 OCOR.sub.9, R.sub.8 is H, OH, --OR.sub.10, --N(rr') or alkyl, R.sub.10 is alkyl, alkenyl, aryl or aralkyl, r and r' being H, alkyl, aryl, aralkyl, etc., r and r' together form a heterocycle, R.sub.9 is alkyl, alkenyl or a sugar residue, R.sub.2 and R.sub.3 are --OR.sub.11 or --OCOR.sub.11, R.sub.11 is H, alkyl, fluoroalkyl, aryl or aralkyl, R.sub.3 in addition being H, R.sub.4 is H, OH, alkyl, alkoxy, F, Cl or --CF.sub.3, R.sub.5 and R.sub.7 are H, OH, alkoxy, .alpha.-substituted alkyl or .alpha.,.alpha.'-disubstituted alkyl, etc., R.sub.6 is H, OH, alkyl, alkoxy, cycloalkyl, etc., R.sub.5 and R.sub.7 cannot simultaneously be OH or alkoxy and R.sub.4, R.sub.5, R.sub.6 and R.sub.7 cannot simultaneously be H, R.sub.5 and R.sub.6 or R.sub.6 and R.sub.Type: GrantFiled: May 25, 1995Date of Patent: August 5, 1997Assignee: Centre International De Recherches Dermatologiques Galderma (Cird Galderma)Inventor: Jean-Michel Bernardon
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Patent number: 5648387Abstract: Dialkyl ethers lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.Type: GrantFiled: March 24, 1995Date of Patent: July 15, 1997Assignee: Warner-Lambert CompanyInventors: Charles Larry Bisgaier, Paul Leroy Creger, Alan Robert Saltiel, Sherrie Rae Tafuri
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Patent number: 5639794Abstract: Methods and compositions employing saponin as synergist in combination with a natural product, such as an aromatic aldehyde, are provided for controlling the colonization and/or growth of plant and animal pathogens, such as fungi, insects, arachnids and non-aquatic mollusks, on materials such as plants, plant parts and agricultural products before, during, after and/or processing. The invention finds use in treating agricultural crops for pathogenic organisms which colonize the surfaces of plant parts and tissues and controlling the level of toxic metabolites present in consumable products derived from plant materials, as well as reducing the health risk associated with their consumption. A method of employing saponin to kill nematodes is also provided.Type: GrantFiled: June 7, 1995Date of Patent: June 17, 1997Assignee: Proguard, Inc.Inventors: Ralph W. Emerson, Bradford G. Crandall, Jr.
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Patent number: 5593994Abstract: This invention relates to ortho substituted phenyl compounds as inhibitors of prostaglandin synthase, to pharmaceutical compositions comprising such compounds and to methods of using such compounds as antiinflammatory and antipyretic agents.Type: GrantFiled: September 29, 1994Date of Patent: January 14, 1997Assignee: The DuPont Merck Pharmaceutical CompanyInventors: Douglas G. Batt, Donald J. P. Pinto, Michael J. Orwat, Joseph J. Petraitis, William J. Pitts
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Patent number: 5587157Abstract: Biowaste treatment agents for treating biowastes in a manner which: (a) keeps noxious and toxic substances from being released from the biowaste, and (b) neutralizes such substances released during the course of stabilizing the biowaste. The treatment agents include a surfactant in an amount of from 1.0 to 99 percent of the treatment agent, a metal component in an amount from 0.5 to 85 percent of the treatment agent, the metal component including a source of zinc, or copper, or a combination of copper with aluminum or iron, and an aldehyde in an amount from 0.1 to 80 percent of the treatment agent.Type: GrantFiled: June 7, 1995Date of Patent: December 24, 1996Inventors: James P. Cox, Robert W. Duffy Cox
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Patent number: 5560912Abstract: The invention relates to the use of an organic extract of the plant Cinnamon or a chemical constituent present in said plant, to prepare a pharmaceutical composition useful to inhibit the growth of Helicobacter pylori and the urease activity of Helicobacter pylori. Most preferred chemical constituents are cinnamaldehyde and methoxycinnamaldehyde. The extract may be used either as a drink, with or without additional flavoring ingredients or transformed into a capsule. The invention also relates to in-vitro method for determininig the inhibition of urease activity of Helicobacter pylori using said organic extract of the plant or chemical constituents present in said plant.Type: GrantFiled: June 27, 1994Date of Patent: October 1, 1996Assignee: Technion Research & Development Foundation Ltd.Inventors: Itzhak Neeman, Mina Tabak, Robert Armon
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Patent number: 5534531Abstract: New compounds having the general formula I ##STR1## wherein L may be H or D; Y may be CN or ##STR2## wherein A may be H, D, alkyl with 1-4 carbon atoms, OR wherein R is H or alkyl with 1-4 carbon atoms, or CR.sub.1 R.sub.2 R.sub.3 wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different and are H or alkyl with 1-4 carbon atoms; Z is H, D, Y or alkyl with 1-4 C-atoms, halogen, nitro, amino, monoalkyl amino or dialkyl amino wherein the alkyl groups have 1-4 C atoms, or OR wherein R may be H or alkyl with 1-4 C-atoms, or CR.sub.4 R.sub.5 R.sub.6 wherein R.sub.4, R.sub.5 and R.sub.6 may be the same or different and may be H or F; X.sub.1 and X.sub.2 may be the same or different and may be OR, NR.sub.1 R.sub.2 or SR, wherein R, R.sub.1 and R.sub.2 may be the same or different and may be alkyl having 1-22 carbon atoms which may be branched or straight chained and/or may be further substituted; or X.sub.1 and X.sub.Type: GrantFiled: January 19, 1993Date of Patent: July 9, 1996Assignee: Norsk Hydro A.S.Inventors: Erik O. Pettersen, Rold O. Larsen, John M. Dornish, Bernt Boorretzen, Reidar Oftebro, Thomas Ramdahl
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Patent number: 5519033Abstract: The present invention relates to a method of treating urinary incontinence in mammals, including humans, using certain quinuclidine derivatives, piperidine derivatives, azanorbornane derivatives of azabiaglo and related compounds.Type: GrantFiled: May 31, 1994Date of Patent: May 21, 1996Assignee: Pfizer Inc.Inventors: Terry J. Rosen, Manoj C. Desai, John A. Lowe, III
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Patent number: 5508310Abstract: This invention relates to the use of a class of compounds as immunopotentiaters, compositions containing such compounds and their manufacture, combinations of such compounds with anti-tumor or anti-infective drugs and the use of such combinations in the prophylaxis or treatment of such diseases arising from tumors or infections.Type: GrantFiled: May 19, 1995Date of Patent: April 16, 1996Assignee: Burroughs Wellcome Co.Inventor: John R. Rhodes
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Patent number: 5487893Abstract: A therapeutical use is provided for cornpounds selected from the group which consists of (a) phenols of formula (I): ##STR1## wherein R is a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C1-12 alkoxy group, a formyl group, a C2-12 alkanoyl group, a C1-12 hydroxyalkyl group, a primary, secondary or tertiary amide group, an OCH.sub.3 group, CH.sub.2 OH or a COOH group or an A--COOH group where A is a C1-11 aliphatic hydrocarbon residue; and (b) the corresponding salts and esters thereof when R is COOH or A--COOH; for obtaining an antiviral drug for use in the human or veterinary therapeutical treatment of viral diseases.Type: GrantFiled: August 2, 1993Date of Patent: January 30, 1996Assignee: FilecoInventor: Robert Vachy
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Patent number: 5380755Abstract: The present invention provides alkyl and alkylbenzyl ethers of substituted hydroquinones and pharmaceutical compositions containing them. The present invention further provides methods of using these compounds and compositions to inhibit monoamine oxidase, particularly monoamine oxidase B. The present invention further provides methods for the treatment of diseases involving monoamine oxidase.Type: GrantFiled: July 24, 1992Date of Patent: January 10, 1995Assignee: The Du Pont Merck Pharmaceutical CompanyInventors: Argyrios G. Arvanitis, Everett L. Scholfield
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Patent number: 5352444Abstract: Biowaste treatment agents for treating biowastes in a manner which: (a) keeps noxious and toxic substances from being released from the biowaste, and (b) neutralizes such substances released during the course of stabilizing the biowaste. The treatment agents include a surfactant in an amount of from 1.0 to 99 percent of the treatment agent, a metal component in an amount from 0.5 to 85 percent of the treatment agent, the metal component including a source of zinc, or copper, or a combination of copper with aluminum or iron, and an aldehyde in an amount from 0.1 to 80 percent of the treatment agent.Type: GrantFiled: May 19, 1992Date of Patent: October 4, 1994Inventors: James P. Cox, R. W. Duffy Cox
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Patent number: 5274002Abstract: Novel trisubstituted phenyl analogs are now found to have activity as for the treatment of congestive heart failure.Type: GrantFiled: September 6, 1990Date of Patent: December 28, 1993Assignee: Warner-Lambert CompanyInventor: Lynn D. Hawkins
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Patent number: 5272178Abstract: The present invention relates to compounds of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and independently represent tert-alkyl, phenyl, or hydrogen; R.sup.3 represents hydrogen or alkyl; X represents O, S or (CH.sub.2).sub.m wherein m is 1 or 2; A represents O or S(O).sub.n wherein n is 0, 1, or 2; p is an integer from 0 to 4; and R represents alkyl; OH; OR.sup.4 wherein R.sup.4 is alkyl; or NR.sup.5 R.sup.6 wherein R.sup.5 is hydrogen or alkyl, and R.sup.6 is hydrogen, alkyl, heterocyclealkyl, substituted heterocyclealkyl, cycloalkyl, substituted cycloalkyl, phenyl, substituted phenyl, phenylalkyl, or substituted phenylalkyl, or NR.sup.5 R.sup.6 together form a heterocyclic ring which may optionally be substituted; or (CH.sub.2).sub.t COOR.sup.7 wherein t is an integer from 1 to 4 and R.sup.7 is hydrogen or alkyl; and the pharmaceutically acceptable salts thereof. The compounds are inhibitors or stimulators of superoxide generation.Type: GrantFiled: April 8, 1993Date of Patent: December 21, 1993Assignee: G. D. Searle & Co.Inventors: Richard A. Mueller, Richard A. Partis
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Patent number: 5216024Abstract: The present invention discloses new and useful compounds including methyl p-hydroxyphenyllactate, its analogues, chemical derivatives and chemically related compounds and their use as antitumor agents, as inhibitors of proliferative cell growth and as prophylactic agents to inhibit and prevent cancer and non-malignant cell growth.Type: GrantFiled: July 15, 1988Date of Patent: June 1, 1993Assignee: Baylor College of MedicineInventors: Barry M. Markaverich, James H. Clark, Rebecca Gregory, Mary Alejandro, Brian S. Middleditch, Gregory A. Johnson, Rajender S. Varma
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Patent number: 5208262Abstract: This invention encompasses a pharmaceutical composition comprising a pharmaceutical carrier and an effective lipoxygenase inhibiting amount of a compound of the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of 1,1-dimethylethyl, halo, phenyl and substituted phenyl; Alk is straight or branched chain lower alkylene; R.sub.4 is hydrogen or lower alkyl; R.sub.3 is hydrogen or lower alkyl. The formulation of this invention are useful as anti-inflammatory and anti-allergy agents.Type: GrantFiled: September 18, 1992Date of Patent: May 4, 1993Assignee: G. D. Searle & Co.Inventor: Richard A. Mueller
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Patent number: 5128051Abstract: A method for controlling biofouling in aqueous environments which comprises providing ortho-phthalaldehyde to aqueous systems susceptible to biofouling. The method of the invention is particularly well suited for use in industrial cooling water systems, paper manufacture and in secondary oil recovery processes.Type: GrantFiled: September 30, 1991Date of Patent: July 7, 1992Assignee: Union Carbide Chemicals & Plastics Technology CorporationInventors: Alan B. Theis, Jonathan Leder
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Patent number: 5079000Abstract: A composition for killing harmful organisms, which contains a clathrate compound composed of one or more natural essential oils and/or derivatives thereof selected from the group consisting of the following substances (1) to (22) and a polymolecular host compound capable of including the natural essential oils and/or derivatives thereof:(1) hinoki oil;(2) 1,8-cineole;(3) l-.alpha.-terpineole;l-carbone;(5) l-menthone;(6) d-pulegone;(7) citronellal;(8) linelool oxide;(9) d,l-citronellol;(10) 3,3,5-trimethylcyclohexanol;(11) l-perillaldehyde;(12) l-carveol;(13) myrtenal;(14) peppermint oil;(15) eucalyptus oil;(16) cinnamic aldehyde;(17) .alpha.-bromo-cinnamic aldehyde;(18) salicylaldehyde;(19) benzaldehyde;(20) paraphenyl-propionaldehyde;(21) paratolualdehyde; and(22) l-menthol.Type: GrantFiled: November 20, 1989Date of Patent: January 7, 1992Assignee: Kurita Water Industries Ltd.Inventors: Ryoichi Takahashi, Tsuneo Mukai, Shigeyuki Mayama
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Patent number: 5066681Abstract: 1-Trifluoromethyl-1-nitro-2-alkoxy-2-aryl-ethanes of the formula ##STR1## in which R.sup.1 represents a straight-chain or branched alkyl radical andR.sup.2 represents an optionally substituted aryl or hetaryl radical,their preparation from an aldehyde of the formula R.sup.2 -CHO, an alcohol of the formula R.sup.1 -OH and trifluoromethylnitromethane in the presence of a compound containing basic groups and antimycotic agents containing these compounds.Type: GrantFiled: September 20, 1989Date of Patent: November 19, 1991Assignee: Bayer AktiengesellschaftInventors: Bernd Baasner, Gunther Beck, Helmut Heitzer, Klaus Scaller
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Patent number: 4997850Abstract: The present invention discloses a method for treating a patient suffering from osteoarthritis comprising administering a physiologically effective amount of pharmaceutical composition containing at least one compound, as an active ingredient, represented by the formula (I): ##STR1## wherein R represents a hydrogen atom or an acyl group; X represents a CHO group, a COOH group, a physiologically acceptable salt thereof or a CH(OR').sub.2 group wherein R' represents an acyl group.Type: GrantFiled: April 12, 1990Date of Patent: March 5, 1991Assignee: Kureha Kagaku Kogyo Kabushiki KaishaInventors: Fumihiko Kimura, Yutaka Mukaida, Koju Watanabe
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Patent number: 4983636Abstract: As a result of research work and investigations relating to the effect of benzaldehyde on cell membranes, it was found that benzaldehyde has high activity in the treatment of selected malignant conditions. Based on this finding, we have now completed the present invention directed to a composition comprising benzaldehyde as the active ingredient. This composition is effective against selected malignant conditions which are carcinoma of the colon, cancer of the stomach, cancer of the tongue, peritonitis carcinomatosa, cancer of the liver and malignancies induced by SF.sub.40 virus.Type: GrantFiled: October 31, 1988Date of Patent: January 8, 1991Assignees: Rikagaku Kenkyusho Wako, Mutsuyuki KochiInventors: Setsuo Takeuchi, Mutsuyuki Kochi
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Patent number: 4906617Abstract: A pharmaceutical or cosmetic composition contains as an active principle a peroxide having an aromatic radical and a saturated group and having the formula ##STR1## wherein R.sub.1 represents linear or branched alkyl having 3 to 17 carbon atoms, substituted or not by one or more halogens, interrupted or not by a carbonyl group and carrying a terminal carboxylic acid group esterified or not or R.sub.1 represents cycloalkyl having 5 to 10 carbon atoms, and R.sub.2 represents hydrogen, halogen, --CF.sub.3, methoxy, ethoxy or acyl having 2 to 16 carbon atoms.The composition is usefully employed in the treatment of various dermatoses including acne.Type: GrantFiled: September 29, 1987Date of Patent: March 6, 1990Assignee: L'OrealInventors: Bernard Jacquet, Michel Hocquaux, Didier Semeria, Didier Saint-Leger
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Patent number: 4898883Abstract: The present invention relates to 1-substituted derivatives of 4-methoxy-2,3,6-trimethylbenzene which are useful in cosmetic or pharmaceutical preparations for use in the treamtnet of dermatological complaints connected with a keratinisation disorder, dermatological complaints having an inflammatory and/or immuno-alleric component or ophthalmological complaints.Type: GrantFiled: July 21, 1987Date of Patent: February 6, 1990Assignee: L'OrealInventors: Gerard Lang, Serge Forestier, Alain Lagrange, Braham Shroot
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Patent number: 4851449Abstract: An odorless sterilizing and disinfecting solution containing 0.025 to 1.0 weight percent phthalaldehyde.Type: GrantFiled: May 21, 1987Date of Patent: July 25, 1989Assignee: Surgikos, Inc.Inventors: Norman I. Bruckner, Michael D. Gordon, Ronald G. Howell
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Patent number: 4847304Abstract: A sterilizing and disinfecting solution is disclosed. The solution contains a saturated dialdehyde such as glutaraldehyde and an aromatic dialdehyde, such as phthalaldehyde, isophthalaldehyde or terephthalaldehyde.Type: GrantFiled: May 21, 1987Date of Patent: July 11, 1989Assignee: Surgikos, Inc.Inventors: Norman I. Bruckner, Michael D. Gordon, Ronald G. Howell
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Patent number: 4801444Abstract: A medicinal preparation for individual prevention of venereal diseases and treatment of urogenital trichomoniasis comprises an efficient quantity of an active principle which is essentially a synergistic mixture of para-nitro-alpha-chlorocinnamic aldehyde of the formula: ##STR1## dimethylsulphoxide and a pharmaceutical excipient. Polyethyleneglycol having a molecular mass of 400 is recommended to be used as the pharmaceutical excipient.A method for treatment of urogenital trichomoniasis consists in application of the medicinal preparation in question to the mucosa of human genitalia in a dose of 1.5 to 10 ml twice a day for 5 to 7 days.Type: GrantFiled: March 3, 1988Date of Patent: January 31, 1989Assignee: Poltavsky Meditsinsky Stomatologichesky InstitutInventor: Vladimir G. Kravchenko
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Patent number: 4778785Abstract: A pharmaceutical composition for retarding and reducing cachexia comprising, as an efficacious ingredient, at least one compound selected from the group consisting of benzaldehyde and 4,6-O-benzylidene-D-glucose, and a method for retarding and reducing cachexia in humans which comprises administering to an affected human at least one said compound.Type: GrantFiled: August 29, 1986Date of Patent: October 18, 1988Assignees: Kaken Pharmaceutical Co., Ltd., Rikagaku KenkyushoInventors: Mutsuyuki Kochi, Shinichiro Esumi, Setsuo Takeuchi
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Patent number: 4619945Abstract: Polyene compounds represented by the formula ##STR1## where R is H or lower alkyl of from 1 to 5 carbon atoms;R.sub.1 is H, lower alkyl of from 1 to 8 carbon atoms or aralkyl; andR.sub.2 is (CH.sub.2).sub.n CH.sub.2 OH, CHO or CO.sub.2 R; wherein n is 1 or 2.The foregoing compounds have been found active in regulating the formation of lipoxygenase and as such possess therapeutic value in the treatment of inflammatory conditions and allergic responses.Type: GrantFiled: October 9, 1985Date of Patent: October 28, 1986Assignee: USV Pharmaceutical CorpInventors: Bernard Loev, Wan-Kit Chan
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Patent number: 4618627Abstract: A catechol derivative represented by the formula ##STR1## The compounds of this invention are useful for the prophylaxis and treatment for various allergic diseases, ischemic heart diseases and inflammations caused by slow reacting substance of anaphylaxis (SRS-A), since the compounds inhibit very potently the formation and release of SRS-A.Type: GrantFiled: May 11, 1984Date of Patent: October 21, 1986Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Kiyoshi Murase, Toshiyasu Mase, Hideki Arima, Kenichi Tomioka
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Patent number: 4613588Abstract: Benzaldehyde and 4,6-O-benzylidene-D-glucose have been found to have analgesic activity. It is believed that this analgesic activity results from the inhibition of enkephalinase. Therefore benzaldehyde and 4,6-O-benzylidene-D-glucose are also useful for inhibiting enkephalinase in humans.Type: GrantFiled: June 28, 1985Date of Patent: September 23, 1986Assignee: Kaken Pharmaceutical Co. Ltd.Inventors: Takashi Katayama, Tadahiko Hazato