Plural Benzene Rings Patents (Class 514/721)
  • Patent number: 10351500
    Abstract: The present invention relates to a composition for preventing or reducing microbial growth, particularly the growth of dermatophytic fungi, and/or aciduric and acidogenic gram-positive bacteria. More particularly, it relates to the use of trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol, or its dihydrostilbene derivatives and/or chemical variants as an anti-microbial agent. The present invention further relates to the management of dermatophytosis often caused by dermatophytic fungi and the management of dental caries often mediated by aciduric and acidogenic gram-positive Streptococci. The present invention therefore has applications in preventing, alleviating and/or treating dermatophytosis and dental caries.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: July 16, 2019
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Hongjie Zhang, Siu Wai Tsang
  • Patent number: 10166203
    Abstract: The present disclosure relates to an anticancer use of a novel compound, i.e., 2-methoxy-4-(3-(4-methoxyphenyl)propyl-1-en-1-yl)phenol. The compound of the present disclosure effectively inhibits the growth of cancer cells and tumors in vitro and in a xenograft animal model. The compound of the present disclosure illustrates an anticancer activity by inhibiting a DNA binding activity of transcription factor STAT 3 in cancer cells, inducing apoptosis of cancer cells, and reducing the expression of a cell cycle regulatory protein. The compound of the present disclosure can be developed as an active ingredient of a strong anticancer drug.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: January 1, 2019
    Assignee: Chungbuk National University Industry—Academic Cooperation Foundation
    Inventors: Jin-Tae Hong, Hee-Pom Lee, Young-Wan Ham, Chun-Sik Kim, Heon-Sang Jung
  • Patent number: 10017442
    Abstract: The present invention relates to a polyphenol derivative of the stilbenoid family, namely trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol, as a remedial agent. In particular, the present invention presents the usage of dihydro-resveratrol or its derivatives/chemical variants in the manufacture of a medicament for the treatment of tumors or cancers. The dihydrostilbenes can be used in the treatment or delay of progression of a cancer in a patient or used in a pharmaceutical formulation for the aforementioned purposes.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: July 10, 2018
    Assignee: Hong Kong Baptist University
    Inventors: Hongjie Zhang, Siu Wai Tsang
  • Patent number: 9956152
    Abstract: A skin-protection composition is shown that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, the usage of Dendrobium ingredients and stilbenoids is shown to reduce the formation of melanin in melanocytes. The usage of Dendrobium ingredients and stilbenoids is also shown to reduce the generation of reactive oxygen species and oxidative free radicals. The use of Dendrobium-derived extracts or ingredients or stilbenoids is shown in the formulation of skin-protection, skin-whitening and/or anti-skin aging products.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: May 1, 2018
    Inventors: Hongjie Zhang, Siu Wai Tsang, Yu Zhu
  • Patent number: 9877931
    Abstract: The present invention relates to a polyphenol derivative of the stilbenoid family, namely trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol, as a remedial agent. In particular, the present invention presents the usage of dihydro-resveratrol as an anti-fibrotic agent in suppressing the activation of pancreatic stellate cells (PSCs). One embodiment of the present invention also relates to the management of pancreatic fibrosis, which is often accompanied with chronic pancreatitis and desmoplastic reaction of pancreatic cancer. Another embodiment of the present invention also has applications in preventing or alleviating or treating pancreatic cancer or pancreatogenic diabetes.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: January 30, 2018
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Hongjie Zhang, Siu Wai Tsang, Yegao Chen
  • Patent number: 9738581
    Abstract: A polyphenol derivative of the stilbenoid family, namely trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol, is disclosed as a remedial agent. In particular, the usage of dihydro-resveratrol as an anti-fibrotic agent in suppressing the activation of pancreatic stellate cells (PSCs) is presented. One embodiment also relates to the management of pancreatic fibrosis, which is often accompanied with chronic pancreatitis and desmoplastic reaction of pancreatic cancer. Another embodiment has applications in preventing or alleviating or treating pancreatic cancer or pancreatogenic diabetes.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: August 22, 2017
    Assignee: Hong Kong Baptist University
    Inventors: Hongjie Zhang, Siu Wai Tsang, Yegao Chen
  • Patent number: 9561193
    Abstract: Described herein are compositions comprising antibacterially effective amounts of a compound of Formula (I): or a salt thereof in which R1 and R2 are each independently (C1-C6) alkyl or (C2 C6) alkenyl, and a carrier. Suitable carriers include orally acceptable carriers and dermatologically acceptable carriers. The disclosed compositions include oral care and personal care compositions useful for treating or preventing oral and skin conditions, respectively.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: February 7, 2017
    Assignee: Colgate-Palmolive Company
    Inventors: Ravi Subramanyam, Neelima Utgikar, Guofeng Xu, Ying Yang, Lin Fei
  • Patent number: 9526706
    Abstract: The present invention relates to a method of using trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol for treating acute pancreatitis in a subject in needs thereof. More particularly, the present invention relates to a method of using dihydro-resveratrol, its derivatives and/or chemical variants as a remedial agent. The present invention particularly relates to the amelioration of tissue injury for the management of acute pancreatitis associated pulmonary injury of a subject.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: December 27, 2016
    Assignee: Hong Kong Baptist University
    Inventors: Zhaoxiang Bian, Siu Wai Tsang, Hongjie Zhang, Aiping Lu, Albert Sun-Chi Chan
  • Patent number: 9309179
    Abstract: The invention relates to hydroxyphenyl derivatives of formula (I); and uses thereof as anti-bacterial and/or anti-parasitic agents.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: April 12, 2016
    Assignee: FAB PHARMA
    Inventors: Alexis Denis, Vincent Gerusz, Yannick Bonvin
  • Patent number: 9150730
    Abstract: The invention relates to inorganic-organic composite particles, in particular composite nanoparticles, wherein the composite particles comprise at least one organically based material containing or being made of at least one wax and an inorganically based material, and to a method for the production thereof and to the use thereof.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: October 6, 2015
    Assignee: BYK—Chemie GmbH
    Inventors: Ulrich Nolte, Michael Berkei, Thomas Sawitowski
  • Publication number: 20150141417
    Abstract: Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue O groups by an ether bond or a carbamate bond, pharmaceutical compositions, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, a metabolic disease, such as diabetes, a vascular disease, such as hypertension and macular degeneration, or a proliferative disease, such as diverse types of cancers.
    Type: Application
    Filed: May 14, 2012
    Publication date: May 21, 2015
    Inventors: Qingqi Chen, Rocio Alejandra Lopez, Jonathan Daniel Heller, Amanda Jean Morris
  • Publication number: 20150125389
    Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R4, R5, X1, X2, X3 and X4 are as defined herein, and wherein the compound comprises at least one F, Cl, Br, I or 123I moiety, are provided. Uses of such compounds for imaging diagnostics in cancer and therapeutics methods for treatment of subjects in need thereof, including prostate cancer as well as methods and intermediates for preparing such compounds are also provided.
    Type: Application
    Filed: September 9, 2014
    Publication date: May 7, 2015
    Applicants: THE UNIVERSITY OF BRITISH COLUMBIA, BRITISH COLUMBIA CANCER AGENCY BRANCH
    Inventors: Raymond John Andersen, Carmen Adriana Banuelos, Javier GARCIA FERNANDEZ, Yusuke IMAMURA, Jian KUNZHONG, Nasrin R. MAWJI, Marianne Dorothy Sadar, Jun Wang, Amy (Hsing Chen) Tien
  • Patent number: 8999399
    Abstract: The invention relates to a novel combined disinfection and decontamination agent comprising at least one vitamin, at least one metal ion, at least one active-surface compound, and at least one further antimicrobial active substance. The agent according to the invention surprisingly shows nearly complete nucleic acid disintegration in addition to an improved disinfectant effect. The agent can be successfully used as a combined decontamination and disinfection agent for skin, mucous membranes, hands, wounds, and/or hair, and instruments and surfaces of all kinds.
    Type: Grant
    Filed: November 14, 2009
    Date of Patent: April 7, 2015
    Assignee: Bose Chemie GmbH
    Inventors: Thomas Lisowsky, Sven Eggerstedt, Richard Bloss, Christiane Ostermeyer, Karlheinz Esser, Frank Bürger, Barbara Krug, Yvonne Feil, Kai-Martin Mueller, Delphine Haase
  • Patent number: 8962693
    Abstract: This invention concerns a method for treatment or prevention of lower urinary tract symptoms with or without pelvic pain in an individual, said method comprising administering to the individual an effective amount of a selective estrogen receptor modulator, or an isomer, isomer mixture or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: February 24, 2015
    Assignee: Hormos Medical Ltd.
    Inventors: Risto Santti, Tomi Streng
  • Publication number: 20150051294
    Abstract: The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau.
    Type: Application
    Filed: April 8, 2013
    Publication date: February 19, 2015
    Applicant: Universtiy of South Florida
    Inventors: Chad Dickey, Umesh Jinwal, Laurent Calcul, Bill J. Baker
  • Publication number: 20150051295
    Abstract: The invention relates to the use of propanol and propenol derivatives as antioxidants, to compositions comprising propanol and propenol derivatives and the preparation thereof, and to certain propanol and propenol derivatives and the preparation thereof.
    Type: Application
    Filed: September 27, 2012
    Publication date: February 19, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Thomas Rudolph, Rene Peter Scheurich
  • Publication number: 20150010635
    Abstract: Controlled release particles are obtained by dissolving a hydrophobic antibiotic compound with a hydrophobic polymerizable vinyl monomer to prepare a hydrophobic solution, blending water with an emulsifier to prepare an aqueous emulsifier solution, emulsifying the hydrophobic solution in the aqueous emulsifier solution, and polymerizing the polymerizable vinyl monomer by mini-emulsion polymerization in the presence of a polymerization initiator, thereby producing a polymer containing an antibiotic compound and having an average particle size of below 1 ?m.
    Type: Application
    Filed: December 27, 2012
    Publication date: January 8, 2015
    Applicant: Japan EnviroChemicals, Ltd.
    Inventors: Junji Oshima, Hideaki Inoue
  • Publication number: 20150004110
    Abstract: The 1-aryl-2-aryloxyethane compounds of Formula 1 in which n and m are zero or equal to 1, provided that n+m=1, R1 and R2 in particular representing hydrogen atoms, R3 and R4 in particular representing hydrogen atoms, halogen atoms, hydroxy or alkoxy groups, and R5 in particular representing hydrogen atoms, hydroxy, alkyl, alkoxy, amino or nitro groups, in cosmetic compositions intended for anti-ageing and/or depigmenting and/or anti-inflammatory and/or wound-healing care.
    Type: Application
    Filed: December 18, 2012
    Publication date: January 1, 2015
    Applicant: DIVERCHIM
    Inventors: Natacha Frison, Benoit Folleas, Jean-Louis Brayer, Florence Wafflart
  • Publication number: 20140369953
    Abstract: Disclosed are compositions comprising a) an antimicrobial agent, which is selected from the group consisting of biocides containing halogen atoms and/or containing phenolic moieties, formic acid, chlorine dioxide, chlorine dioxide generating compounds, dialdehydes; components containing an antimicrobial metal such as antimicrobial silver, and b) a polyamine, especially a polyethylenimine. The polyamine is effective as a booster for the antimicrobial agent.
    Type: Application
    Filed: February 19, 2013
    Publication date: December 18, 2014
    Applicant: BASF SE
    Inventors: Janina Purschwitz, Stephan Hüffer, Alejandra Garcia Marcos, Menno Hazenkamp
  • Publication number: 20140363388
    Abstract: The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.
    Type: Application
    Filed: January 13, 2014
    Publication date: December 11, 2014
    Applicant: UNIGEN, INC.
    Inventors: Sandip K. Nandy, Jiyun Liu, Alexandre Mikhailovitch Nesterov, Carmen Hertel, Abeysinghe A. Padmapriya
  • Patent number: 8895084
    Abstract: An oral composition for at least one or treating and inhibiting an oral inflammatory condition comprising: a Camellia extract including at least about 30% epigallocatechin gallate, at least about 50% total catechins, and at least about 60% total polyphenols; and a substantially water insoluble non-cationic anti-bacterial agent.
    Type: Grant
    Filed: October 24, 2005
    Date of Patent: November 25, 2014
    Assignee: Colgate-Palmolive Company
    Inventors: Cortney L. Worrell, Harsh M. Trivedi, Kimberlee Panaligan, Tao Xu
  • Publication number: 20140336259
    Abstract: The present document describes a phytochemical isolated from maple syrup and composition comprising the same. More specifically, the document describes an antioxidant phytochemical compound, derivates thereof, and composition comprising the same. The document also describes a process of synthesizing the antioxidant phytochemical compound.
    Type: Application
    Filed: June 11, 2012
    Publication date: November 13, 2014
    Inventors: Navindra Seeram, Julie Barbeau, Genevieve BeLand, Keykavous Parang
  • Publication number: 20140328895
    Abstract: The present invention discloses a liquid precursor composition adapted for application on a on a desired surface, this composition comprising: a. at least one therapeutic agent suitable for the treatment or prevention of a disorder or pathological condition, wherein said disorder or pathological condition excludes oral disorders, b. at least one acidic-pH sensitive polymer, c. at least one hydrophobic polymer, and d. a pharmaceutically acceptable volatile solvent, wherein a weight ratio between the at least one hydrophobic polymer and the at least one acidic-pH sensitive polymer is larger than 1.
    Type: Application
    Filed: March 25, 2012
    Publication date: November 6, 2014
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
    Inventors: Michael Friedman, Doron Steinberg, Eran Lavy
  • Publication number: 20140309581
    Abstract: Chronic wounds may be treated by debriding necrotic and other devitalized tissue from the wound, and applying to the wound an extracellular polymeric substance solvating system comprising a metal ion sequestering agent, surfactant and buffering agent. The solvating system disrupts biofilms which may be present in the wound and aids or enables the resumption of normal healing.
    Type: Application
    Filed: June 25, 2014
    Publication date: October 16, 2014
    Inventors: Matthew F. Myntti, Dana A. Oliver, James B. Hissong, Jennifer G. Medina
  • Patent number: 8853282
    Abstract: A topical liquid formulation is provided which contains a combination of three active ingredients for treating fleas and ticks in domestic animals. Total concentration of the active hydrophobic and hydrophilic ingredients can exceed 60 weight percent. In contrast to commonly available flea treatments, the new insecticidal composition is safe and effective for both felines and canines and a single topical application can be effective for at least several weeks.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: October 7, 2014
    Assignee: Sumitomo Corporation
    Inventor: Ian Cottrell
  • Publication number: 20140296349
    Abstract: The present invention relates to an antimicrobial cleaning composition comprising at least one sugar surfactant and a compound of the formula (I) as biocide, and to the use of the sugar surfactants for improving the activity of the biocide.
    Type: Application
    Filed: September 20, 2012
    Publication date: October 2, 2014
    Applicant: BASF SE
    Inventors: Sabine Both, Christian Muckenschnabel, Menno Hazenkamp
  • Publication number: 20140288186
    Abstract: The present invention provides methods of administering a Dendrobium polyphenol in an amount effective to lower blood sugar, treat hepatic disease, obesity or diabetes. Exemplary hepatic disease includes fibrosis, fatty liver and hepatitis. Moreover, the Dendrobium polyphenol is extracted from the plants of the genus Dendrobium.
    Type: Application
    Filed: October 30, 2013
    Publication date: September 25, 2014
    Applicant: Tunghai University
    Inventors: Chang-Chi Hsieh, Chin-Tung Wu, Jie-Yu Chen, Yi-Chieh Li, Hsin-Sheng Tsay
  • Patent number: 8829058
    Abstract: Uric acid in mammalian subjects is reduced and excretion of uric acid is increased by administering a compound of Formula I or a pharmaceutically acceptable salt thereof. In Formula I m is 0, 1, 2, 3 or 4; n is 0 or 1; t is 0 or 1; q is 0 or 1; and r is 0, 1 or 2. R6 is hydrogen, O or hydroxyl. R7 is hydrogen or alkyl having from 1 to 3 carbon atoms. One of R8 and R9 is alkyl having from 1 to 3 carbon atoms, and the other is hydrogen or alkyl having from 1 to 3 carbon atoms. R10 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms or alkoxy having from 1 to 3 carbon atoms. X is C(O) and r is 0 and t is 0; or X is NH(R11) wherein R11 is hydrogen or alkyl having from 1 to 3 carbon atoms.
    Type: Grant
    Filed: March 13, 2009
    Date of Patent: September 9, 2014
    Assignee: Wellstat Therapeutics Corporation
    Inventors: James Dennen O'Neil, Michael K. Bamat, Reid W. von Borstel, Shalini Sharma, Ramachandran Arudchandran
  • Patent number: 8816129
    Abstract: The present invention relates to chemical total synthesis methods of six novel protein tyrosine phosphatase-1B (PTP1B) inhibitors and application of the inhibitors in the preparation of medicaments for treating type 2 diabetes mellitus (T2DM). The PTP1B inhibitors use one or more of the six compounds represented by the structural formulae 1, 2, 3, 4, 5 and 6, as active components. The compounds can enhance the sensitivity of an insulin receptor by inhibiting the activity of PTP1B, thereby having a favorable therapeutic effect on insulin-resistant T2DM.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: August 26, 2014
    Assignee: Institute of Oceanology, Chinese Academy of Sciences
    Inventors: Dayong Shi, Shuju Guo, Xiao Fan, Weishen Lu, Yongchao Cui
  • Publication number: 20140235714
    Abstract: The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of a dual kinase inhibitor. Catecholic butanes cane serve as dual kinase inhibitors for purposes of methods described herein. Subjects can be further treated by co-administering an EGFR inhibitor. The present application also relates to analyzing a sample with respect to levels of IGF-1R and EGFR and comparing levels of IGF-1R and EGFR to a control. Patients can be selected for treatment with a catecholic butane based on the assessment; optionally, patients can be further treated with an EGFR inhibitor, an IGF-1R inhibitor, or both.
    Type: Application
    Filed: April 25, 2014
    Publication date: August 21, 2014
    Applicant: TriAct Therapeutics, Inc.
    Inventors: Thomas F. WHITE, Edward F. SCHNIPPER, Dan HOTH
  • Publication number: 20140221384
    Abstract: The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.
    Type: Application
    Filed: April 7, 2014
    Publication date: August 7, 2014
    Applicant: ERIMOS PHARMACEUTICALS LLC
    Inventors: Jonathan Daniel Heller, Qingqi Chen, Rocio Alejandra Lopez, Amanda Jean Morris
  • Patent number: 8796326
    Abstract: A fire ant killer chemical composition (the “FAK Composition”) for effective killing of fire ants where the FAK Composition utilizes a minimal amount of active ingredients thereby significantly reducing safety concerns with respect to the use of said active ingredients, the FAK composition having a dish detergent composition and an insecticide composition.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: August 5, 2014
    Inventor: Harold V. Hutchins
  • Publication number: 20140213589
    Abstract: The invention relates to hydroxyphenyl derivatives of formula (I); and uses thereof as anti-bacterial and/or anti-parasitic agents.
    Type: Application
    Filed: March 28, 2014
    Publication date: July 31, 2014
    Applicant: FAB PHARMA S.A.S.
    Inventors: Alexis DENIS, Vincent Gerusz, Yannick Bonvin
  • Patent number: 8785503
    Abstract: The present invention provides a novel biphenyl compound or pharmaceutically acceptable salts thereof, methods for preparing the same, and pharmaceutical compositions for preventing or treating diabetic complications containing the same as an active ingredient. Novel biphenyl compounds, according to the present invention, effectively suppress generation activity of advanced glycation end products, which cause diabetic complications and are a criterion for evaluating the effectiveness of a treating agent for diabetic complications, and show an excellent therapeutic effect on retina blood vessels, increased occludin, and decreased angiogenic growth factor in actual diabetic retinopathy induced retina. Thus, novel biphenyl compounds according to the present invention can be used effectively as an active ingredient in compositions for preventing or treating diabetic complications such as diabetic retinopathy.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: July 22, 2014
    Assignee: Korea Institute of Oriental Medicine
    Inventors: Jin Sook Kim, Young Sook Kim, Jung Hyun Kim, Eun Jin Shon, Ki Mo Kim, Chan-Sik Kim, Dong Ho Jung, Yun Mi Lee, Kyu Hyung Jo, Ohn Soon Kim, Nam-Hee Yoo
  • Publication number: 20140193346
    Abstract: Herbal composition and method for the treatment of inflammatory pain associated with tendonitis, bursitis, arthritis, carpal tunnel syndrome, tennis elbow, plantar fasciitis, sports injuries, lower back pain and overexertion, gingivitis and muscle aches, that is compliant with HPUS monographs and/or over-the-counter FDA topical analgesic monograph requirements.
    Type: Application
    Filed: January 7, 2013
    Publication date: July 10, 2014
    Applicant: DRT LABORATORIES LLC
    Inventor: Ronit Arginteanu
  • Publication number: 20140193355
    Abstract: A denial protector liquid including a barrier and antimicrobial materials is disclosed. The protector liquid can be sprayed onto the skirt. The protector liquid can have a dispersant and moisturizer. When the base and solvents of the liquid evaporate, a polymer barrier and antimicrobial material can continue to reside on the skin.
    Type: Application
    Filed: January 7, 2013
    Publication date: July 10, 2014
    Inventors: Marie H. JHIN, Hanafi TONOJO
  • Patent number: 8772353
    Abstract: This invention relates to a method for enhancing the bioavailability of a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to the individual in connection with the intake of food.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: July 8, 2014
    Assignee: Hormos Medical Ltd.
    Inventor: Markku Anttila
  • Publication number: 20140186278
    Abstract: An anhydrous multiphase gel system consisting of an outer lipid matrix and an inner phase gelled by means of a polymer is described, which can be obtained by a) Melting the lipid phase with the formation of a liquid lipid phase, b) Mixing and homogenizing polymers or polymer blends capable of swelling with the formation of a polymer phase to be dispersed, c) Combining the polymer phase with the liquid lipid phase and homogenizing the phases, and d) Cold stirring the phase mixture until a solid gel-like mixed structure of the entire system is formed. The anhydrous multiphase gel system is particularly suitable for taking up difficulty soluble active substances in high concentration and for providing topical and transdermal applications. The described system is called an EDRS, “Entrapped Drug Reservoir System”.
    Type: Application
    Filed: September 19, 2013
    Publication date: July 3, 2014
    Inventor: Patrick Franke
  • Publication number: 20140161892
    Abstract: The present invention relates to nanoparticles for encapsulating compounds, the preparation and uses thereof, said nanoparticles being based on half (C1-C4) alkyl esters of poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA) copolymers. Said nanoparticles can encapsulate or incorporate a product of interest for use in the agricultural, cosmetic, food or pharmaceutical fields.
    Type: Application
    Filed: April 16, 2012
    Publication date: June 12, 2014
    Applicant: BIONANOPLUS, S.L.
    Inventors: Hesham H.A. Salman, Izaskun Goni Azcarate
  • Publication number: 20140142067
    Abstract: The present invention is directed to use of a series of compounds and compositions comprising the same for activating telomerase and treating diseases, disorders and/or conditions related thereto.
    Type: Application
    Filed: November 12, 2013
    Publication date: May 22, 2014
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Aviv GAZIT, Shimon SLAVIN, Esther PRIEL, Sara YITZCHAK
  • Patent number: 8729136
    Abstract: The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: May 20, 2014
    Assignee: Unigen, Inc.
    Inventors: Qi Jia, Ji-Fu Zhao
  • Publication number: 20140135297
    Abstract: The present application provides an aqueous, stable, VOC-free microemulsion based antimicrobial disinfectant and/or cleaning concentrate composition capable of inhibiting or killing gram(+), gram(?) and methicillin-resistant Staphylococcus aureus (MRSA) comprising (i) a water-soluble matrix composite made of (a) water-soluble polymer, and (b) water-soluble surfactant; (ii) a blend of antimicrobial agents comprising (a) at least one compound selected from phenols, halogenated phenols, derivatives of phenols, derivatives of halogenated phenols, bis -phenols, cresols, resorcinols, halogenated hydroxyl diphenylethers, anilides or combinations thereof; and (b) at least one compound derived from essential oils; and (iii) optionally, one or more additives. Also, there is described a method of use and process for preparing the composition.
    Type: Application
    Filed: June 8, 2012
    Publication date: May 15, 2014
    Applicant: ISP Investments Inc.
    Inventors: Kolazi S Narayanan, Domingo Jon, Patel V. Jayanti, Liu Xuejun, Karen Winkowski, Raman Premachandran, Lindstrom Susan
  • Patent number: 8722746
    Abstract: The invention relates to hydroxyphenyl derivatives of formula (I); and uses thereof as anti-bacterial and/or anti-parasitic agents.
    Type: Grant
    Filed: April 16, 2007
    Date of Patent: May 13, 2014
    Assignee: Fab Pharma S.A.S.
    Inventors: Alexis Denis, Vincent Gerusz, Yannick Bonvin
  • Patent number: 8710104
    Abstract: The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of a dual kinase inhibitor. Catecholic butanes cane serve as dual kinase inhibitors for purposes of methods described herein. Subjects can be further treated by co-administering an EGFR inhibitor. The present application also relates to analyzing a sample with respect to levels of IGF-1R and EGFR and comparing levels of IGF-1R and EGFR to a control. Patients can be selected for treatment with a catecholic butane based on the assessment; optionally, patients can be further treated with an EGFR inhibitor, an IGF-1R inhibitor, or both.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: April 29, 2014
    Assignee: Triact Therapeutics, Inc.
    Inventors: Thomas F. White, Edward F. Schnipper, Dan Hoth
  • Patent number: 8691845
    Abstract: The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: April 8, 2014
    Assignee: Erimos Pharmaceuticals LLC
    Inventors: Jonathan Daniel Heller, Qingqi Chen, Rocio Alejandra Lopez, Amanda Jean Morris
  • Patent number: 8686050
    Abstract: This invention provides compound having a structure of Formula I or Formula II Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: April 1, 2014
    Assignees: The University of British Columbia, British Columbia Cancer Agency Branch
    Inventors: Marianne D. Sadar, Nasrin R. Mawji, Jun Wang, Raymond J. Andersen, David E. Williams, Mike Leblanc
  • Publication number: 20140080917
    Abstract: An aqueous fabric care composition having a thickener and an antibacterial compound. The composition has a high storage stability. The composition has from about 0 wt % to about 5 wt % of anionic surfactant, from about 0 wt % to about 3 wt % of cationic surfactant, from about 0 wt % to about 3 wt % of a non-ionic surfactant, from about 0.01 wt % to about 15 wt % of a thickener, from about 0.01% to about 15% of a non-ionic antibacterial compound having a C log P above about 2 and water.
    Type: Application
    Filed: September 13, 2013
    Publication date: March 20, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Hugo Jean Marie Demeyere, Pieter Jan Maria Saveyn
  • Publication number: 20140068874
    Abstract: A non-aqueous liquid cleaning composition for applicators used for applying non-aqueous hair removal compositions to the skin. The composition includes a solubilizing oil effective for solubilizing the non-aqueous hair removal composition, e.g., mineral oil, and an effective antibacterial amount of an antibacterial agent, e.g., triclosan. The composition may also include fragrances and additional bacteriocides, e.g., phenoxyethanol. When the applicator is contacted with the heated cleaning composition any hair removal composition and bacteria on the applicator are removed therefrom and the applicator is ready for reuse. It is preferred to use surgical stainless steel applicators. Also provided are methods of using these compositions and kits containing, among other items, such compositions and applicators.
    Type: Application
    Filed: September 8, 2012
    Publication date: March 13, 2014
    Inventor: Normajean Fusco
  • Patent number: 8669292
    Abstract: The invention provides compositions and formulations comprising catechol and/or acetogenins and various combinations thereof; including various combinations with other ingredients including botanical preparations containing acetogenin, an extract of green tea or a therapeutically active flavanoid contained in green tea; and one or more quinones. The invention includes a pharmaceutical composition including a salt of rhodizonic acid, an OH anion-generating base, a non-toxic acid, a quinone, a salt-containing sulfite, catechol and optionally, an acetogenin and an extract of green tea. The compositions and formulations demonstrate positive effects against a broad variety of cancer, autoimmune diseases, viruses and provides antioxidant protection against peroxyl hydrophilic, peroxyl lipophilic, hydroxyl, peroxynitrite and super oxide radicals. The compositions and formulations can be used for nutritional and nutraceutical uses, and used as dietary supplements.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: March 11, 2014
    Assignee: Orion Therapeutics, LLC
    Inventor: Jerome Godin
  • Patent number: 8658838
    Abstract: The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: February 25, 2014
    Assignee: Unigen, Inc.
    Inventors: Sandip K. Nandy, Jiyun Liu, Alexandre Mikhailovitch Nesterov, Carmen Hertel, Abeysinghe A. Padmapriya